<?xml version="1.0" encoding="UTF-8"?>
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<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCP8</accession>
    <name>C4YCP8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_00282</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the GAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCP8"/>
    <dbReference type="PaxDb" id="5476-C4YCP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00282"/>
    <dbReference type="HOGENOM" id="CLU_080002_1_0_1"/>
    <dbReference type="OMA" id="KPQDGIV"/>
    <dbReference type="OrthoDB" id="2187159at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="111"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="130"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ42084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="196" mass="20369" checksum="C730E1F04ACB7E63" modified="2010-10-05" version="1">MNRGRGGFRGGRGGRSGPVQYGPPDTVLEMGSFMQACEGDIVCRSINVKIPYFNAPIYLENKTQVGKVDEILGPLNEVFFTIKPSEGVKAESFKEGDKFYIGPDKLLPLERFLPKPPSVGPKPKRKTGGKSAGGSSRGGFSSRGGGRGGFSSRGGGRGGFSSRGGGRGGFSSRGGGRGGARGNSRGGFRGGRGGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCU6</accession>
    <name>C4YCU6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_00330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCU6"/>
    <dbReference type="SMR" id="C4YCU6"/>
    <dbReference type="PaxDb" id="5476-C4YCU6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00330"/>
    <dbReference type="HOGENOM" id="CLU_169255_2_0_1"/>
    <dbReference type="OMA" id="PRTNKYP"/>
    <dbReference type="OrthoDB" id="996720at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002673">
        <property type="entry name" value="Ribosomal_eL29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01779">
        <property type="entry name" value="Ribosomal_L29e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ42132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="63" mass="7112" checksum="24025A1904EA683E" modified="2009-07-28" version="1">MAKSKNHTAHNQTRKAHRNGIKKPKTYKYPSLKGVDAKFKRNHRYALHGTAKALAKARAEKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD62</accession>
    <name>C4YD62_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_00452</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD62"/>
    <dbReference type="PaxDb" id="5476-C4YD62"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00452"/>
    <dbReference type="HOGENOM" id="CLU_049076_0_0_1"/>
    <dbReference type="OMA" id="YCGSMDD"/>
    <dbReference type="OrthoDB" id="7608935at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043633">
        <property type="term" value="P:polyadenylation-dependent RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016713">
        <property type="entry name" value="Air1/2_Saccharomycetales"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049024">
        <property type="entry name" value="AIR2-like_ZnK4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051644">
        <property type="entry name" value="TRAMP_AT-DNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21759">
        <property type="entry name" value="AIR2-like_ZnK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018162">
        <property type="entry name" value="PolyA_pol_Air1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="243"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="309"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ42248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="381" mass="42846" checksum="2150D454550AC1EB" modified="2009-07-28" version="1">MSGTLPFIEDSTGEKFKRQKYKEQSFVESKERGSRDIKEHTPTTALSYDEVNDDLDELVALRGEGRYFGVTDPDDESGISRQSLGPLCANCYKRGHTRAKCTVVICHKCGAIDDHYESQCPTTIICSRCGEKGHIVSQCKSKIRKRQYCRTCDSFKHGDENCPSIWRSYITKSPSQGENEESSVLPRIYCYNCASNEHFGDECDKPRSSRIPNFGSAFSGNNLPKKYRNLYFKRLRAASNSRIGDEEYRPTTSTRDYTSNFTPSSRYEGFGSQGFSRNGGDHPSRSGFFPKRQSSGFGSSNGFSRTPKGPSQDNRSKGKFNSNAYGSKSSYNQPTRTGMINQNGSQDQRGIYRNSTRGGPQPTRSGLIANRKSKNFKKMKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDA1</accession>
    <name>C4YDA1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BRO1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_00491</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palA/RIM20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YDA1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00491"/>
    <dbReference type="HOGENOM" id="CLU_007181_2_1_1"/>
    <dbReference type="OMA" id="VSHAEEM"/>
    <dbReference type="OrthoDB" id="64867at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09241">
        <property type="entry name" value="BRO1_ScRim20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08915">
        <property type="entry name" value="V_Alix_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF39">
        <property type="entry name" value="PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="3">
        <location>
            <begin position="4"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="748"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="754"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ42287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="785" mass="90697" checksum="DBF95A34716870BF" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDB1</accession>
    <name>C4YDB1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_00501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDB1"/>
    <dbReference type="PaxDb" id="5476-C4YDB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00501"/>
    <dbReference type="HOGENOM" id="CLU_373369_0_0_1"/>
    <dbReference type="OMA" id="PPDIDPY"/>
    <dbReference type="OrthoDB" id="442087at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="6"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ42297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="730" mass="84653" checksum="AD8609D367BCA592" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDF2</accession>
    <name>C4YDF2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SUN-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_00546</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Interacts with EMP65.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the SLP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDF2"/>
    <dbReference type="PaxDb" id="5476-C4YDF2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00546"/>
    <dbReference type="HOGENOM" id="CLU_006633_4_0_1"/>
    <dbReference type="OMA" id="YVIIELC"/>
    <dbReference type="OrthoDB" id="266334at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000099">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="13">
        <location>
            <begin position="29"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="426"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ42338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="455" mass="52115" checksum="14531CF9CB757AD1" modified="2009-07-28" version="1">MSFEEWKKQKIESNTTTSNNYSMNGSSESKSITPSNHSSVISTNVTLMEADGKVYKDKFNFASVDCAATIMKTNAQAKGASAILKENKDSYLLNECSVKHKYVIIELCQDILVDSVVIGNFEFFSSIFKDIRISVSDRFPSQNWKELGQFTASNIRDVQTFKIENPLIWARYLKLEILSHYGNEFYCPISIVRVHGKTMMDEFKEDEEGNQHMGAIKEEEPPTPQTIEEDVLLINQTTLNECRVRLPHLQLNEFLKSFNSSNQEFCVPSDAEPQVTTAKTTTAITTQESIYKNIMKRLSLLESNATLSLLYIEEQSKLLSTAFSNLEKRQTTNFNTLISSVNSTLMNQLMVFKESYYELYEQYGNLFKMQENSHRQLLAETNKKVGLLSSELTFQKRVSIFNSIIIICLLVYVILTRDVAIEYPEDELNEKSPSPQSKKLSSPFIPIRYKKSKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDS2</accession>
    <name>C4YDS2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent helicase IRC3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_00669</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDS2"/>
    <dbReference type="PaxDb" id="5476-C4YDS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00669"/>
    <dbReference type="HOGENOM" id="CLU_014765_0_0_1"/>
    <dbReference type="OMA" id="YMELAKD"/>
    <dbReference type="OrthoDB" id="16911at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036121">
        <property type="term" value="F:double-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061749">
        <property type="term" value="F:forked DNA-dependent helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032042">
        <property type="term" value="P:mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18032">
        <property type="entry name" value="DEXHc_RE_I_III_res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18799">
        <property type="entry name" value="SF2_C_EcoAI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050742">
        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="46"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="259"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ42458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="655" mass="75470" checksum="B6D924F6CBF5BD1A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YE56</accession>
    <name>C4YE56_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="7">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_00809</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="7"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YE56"/>
    <dbReference type="PaxDb" id="5476-C4YE56"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00809"/>
    <dbReference type="HOGENOM" id="CLU_009049_1_0_1"/>
    <dbReference type="OMA" id="WAYSPIS"/>
    <dbReference type="OrthoDB" id="3349449at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="240"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="610"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ42592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="700" mass="80708" checksum="8C5059870ED154FD" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEA0</accession>
    <name>C4YEA0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_00854</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEA0"/>
    <dbReference type="PaxDb" id="5476-C4YEA0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00854"/>
    <dbReference type="HOGENOM" id="CLU_015166_0_0_1"/>
    <dbReference type="OMA" id="YWWGYES"/>
    <dbReference type="OrthoDB" id="1747031at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045315">
        <property type="entry name" value="Mtm1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760:SF2">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="129"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="241"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ42636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="338" mass="37893" checksum="F38E69501F7444F1" modified="2009-07-28" version="1">MISACSGSLVTSLVVTPFDVIRIRIQQQSILPQEQPCCQLHFPEHNFPKQKVPVEMAPELFWIHDKYCQSAESCTRIYSTFQGFSTVAKHEGVGTLWRGLSLTLLMAVPSNIIYFTGYEYIRDHSPISNHPLNPLFCGSLARTLSATFVAPAELIKTRLQSIPTDSKSASHILSNLLRDSSAAVKKDGVRTMFKGLGITLWRDVPFSGIYWSSYEYFKAFFARTLKTDFNNPTRGGIDDWKVFATSFLSGSISGTIAAFFTNPFDVGKTRIQITMQENEKISHPNMFKYLYKIYKNEGMGALYAGFGPRVMKIAPACAIMISSYEVGKKFFKNGNNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEG4</accession>
    <name>C4YEG4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_00921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEG4"/>
    <dbReference type="PaxDb" id="5476-C4YEG4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00921"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_1"/>
    <dbReference type="OMA" id="FNRMRPG"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF15">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ42700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="348" mass="39883" checksum="D0013007AD5EC2E3" modified="2010-10-05" version="1">MSIELKYNNLGESGLKIAPIIVGCMSYGDKRWAQWVLEDEEKIFQILKRCYDVGLRTFDTADVYSNGKSEELIGKFIKKFNIPRDRIVILSKVFFPVDPQTPGFSLATRDNFPVLDYYNSQGLSRKHVLQAVQNSVERLGTYIDVLQIHRLDKDTPKKEIMKTLNDVVDQGLARYIGASSMKATELAQLQFIAEQNHWHKFISMQNYYNLIHREEEREMIPFCKDNFISKVGIIPWSPIARGVLTRPVDTSSENSRDKLDKTFKLLHLDELTDADKEIISRVEKIAKDHKVSMAVVATAWVISKGCNPIVGLSSVERVDDILKATVLKLTEEDIKYLEEPYVPKQPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEH8</accession>
    <name>C4YEH8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEH8"/>
    <dbReference type="PaxDb" id="5476-C4YEH8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00935"/>
    <dbReference type="HOGENOM" id="CLU_066478_0_0_1"/>
    <dbReference type="OMA" id="IFKDAHW"/>
    <dbReference type="OrthoDB" id="4019734at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="345" mass="39361" checksum="6C5C5ED0D1BE6747" modified="2009-07-28" version="1">MLGSTTKRILVNSSKRSIRFNSSNNSKNGGDAAKLNLSDLFKRIDQVSAKATEFKNKTSSSRSFEAGNRRPGWQRNENDNFANNRAVRNNFNEGEQQQHQQIPKQHQQQREGNSQANFRGPRSNEFAPRSNTRPSRFPKTVDGERAPVARFNGRGDRPSGSNDRSFRRSTPRRNFIESKPEVRKPTVARPINSKQLTPVPLQPKVIAEDFFYGKVPSINATVASRLASIAKLSLNDSKYPYMLPKEVIDQAYPGQRNRFILQQNWKINPNEDVLKERVQTIVLGQTKDLEYKGKKTELASRTLHDININPNLNLEQKNTMFNIVNGLTDIKTIFKDAHWKKQASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEL9</accession>
    <name>C4YEL9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_00976</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEL9"/>
    <dbReference type="SMR" id="C4YEL9"/>
    <dbReference type="PaxDb" id="5476-C4YEL9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00976"/>
    <dbReference type="HOGENOM" id="CLU_062828_3_1_1"/>
    <dbReference type="OMA" id="ANEMFIN"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000008">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="8"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="16">
        <location>
            <begin position="92"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ42755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="131" mass="13824" checksum="CBB27515958B3108" modified="2009-07-28" version="1">MSGGKGKAGSSEKASTSRSAKAGLTFPVGRVHRLLRKGNYAQRIGSGAPVYLTSVLEYLAAEILELAGNAARDNKKSRIIPRHLQLAIRNDEELNKLLGDVTIAQGGVLPNIHQSLLPAKKAKAGAASQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEN8</accession>
    <name>C4YEN8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit SPC19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Outer kinetochore protein SPC19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_00995</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="16">Component of the DASH complex consisting of ASK1, DAD1, DAD2, DAD3, DAD4, DAM1, DUO1, HSK3, SPC19 and SPC34, with a stoichiometry of one copy of each subunit per complex. Multiple DASH complexes oligomerize to form a ring that encircles spindle microtubules and organizes the rod-like NDC80 complexes of the outer kinetochore. DASH complex oligomerization strengthens microtubule attachments. On cytoplasmic microtubules, DASH complexes appear to form patches instead of rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex SPC19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEN8"/>
    <dbReference type="SMR" id="C4YEN8"/>
    <dbReference type="PaxDb" id="5476-C4YEN8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00995"/>
    <dbReference type="HOGENOM" id="CLU_112993_1_0_1"/>
    <dbReference type="OMA" id="HKNGYDV"/>
    <dbReference type="OrthoDB" id="3361333at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013251">
        <property type="entry name" value="DASH_Spc19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08287">
        <property type="entry name" value="DASH_Spc19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="14" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="76"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ42774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="175" mass="20454" checksum="40A96C3D4876AE23" modified="2009-07-28" version="1">MTQQDLPQNQRFNNLDNCTDSLRQSIKILQQSNKILDETLQDSTRLTKILSTNKVFDLIPELDLNDAKSNFTKNITPQLNQQLNKLEDELIQLQTKKTTLTNKLKLINVRLKNYEKKGNKEEGGKNFNSNGLSDIDIDNLLTNRHKNGYDVNKLHQLRFLRDKKTRLQYSLNRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEP0</accession>
    <name>C4YEP0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_00997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEP0"/>
    <dbReference type="PaxDb" id="5476-C4YEP0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00997"/>
    <dbReference type="HOGENOM" id="CLU_022767_0_0_1"/>
    <dbReference type="OMA" id="PNIEDNL"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF37">
        <property type="entry name" value="LD47843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="215"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="712"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ42776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="861" mass="96920" checksum="0E8D4F979D7EBA7C" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEV0</accession>
    <name>C4YEV0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">UBZ4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_01058</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEV0"/>
    <dbReference type="PaxDb" id="5476-C4YEV0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01058"/>
    <dbReference type="HOGENOM" id="CLU_017985_0_1_1"/>
    <dbReference type="OMA" id="RIILSQC"/>
    <dbReference type="OrthoDB" id="10265467at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18139">
        <property type="entry name" value="HLD_clamp_RarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3710.10:FF:000005">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000001">
        <property type="entry name" value="Putative AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000137">
        <property type="entry name" value="Replication-associated recombination protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3710.10">
        <property type="entry name" value="DNA polymerase III clamp loader subunits, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051314">
        <property type="entry name" value="AAA_ATPase_RarA/MGS1/WRNIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779:SF7">
        <property type="entry name" value="ATPASE WRNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779">
        <property type="entry name" value="WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBZ4-type" evidence="12">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="30"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="635"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ42836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="678" mass="76629" checksum="0DA927584D14A3BD" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF22</accession>
    <name>C4YF22_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Phosphomannomutase</fullName>
            <ecNumber evidence="5 13">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_01133</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 13"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF22"/>
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    <dbReference type="PaxDb" id="5476-C4YF22"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="16"/>
        </location>
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        <location>
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            <position position="16"/>
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        <ligand>
            <name>Mg(2+)</name>
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        <location>
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            <name>alpha-D-mannose 1-phosphate</name>
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        <location>
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        <source>
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        <source>
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        <source>
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    <sequence length="252" mass="29019" checksum="25455FC315D85212" modified="2009-07-28" version="1">MSFANKQDPKTLVLFDVDGTLTPARLTISEEMKKTLEKLREKVVIGFVGGSDLSKQVEQLGPNVLNDFDYCFSENGLTAYKLGKELASQSFINWIGNEKYNKLVKFILRYLSDIDLPIRRGTFIEFRNGMINVSPIGRNASTQERNDYEKFDKQHHIRETMVEALKKEFPDFGLTYSIGGQISFDVFPTGWDKTYCLQHVEDEHFENIHFFGDKSYKGGNDYEIYNDPRTIGHAVNSPDDTIRILNETFKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFA4</accession>
    <name>C4YFA4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CAWG_01218</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:DNA-templated transcription"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
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    </dbReference>
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        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
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        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
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        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
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        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
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    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb2_3"/>
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        <property type="entry name" value="RNA_pol_Rpb2_4"/>
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        <property type="entry name" value="RNA_pol_Rpb2_5"/>
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        <property type="entry name" value="RNA_pol_Rpb2_7"/>
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        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
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        <property type="entry name" value="PRK09606.1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
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    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15 23" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="19">
        <location>
            <begin position="37"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="214"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="476"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="575"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="677"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="16">
        <location>
            <begin position="760"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="1133"/>
            <end position="1225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EEQ42990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1234" mass="139852" checksum="6DA4E9421FCE7DBB" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFD1</accession>
    <name>C4YFD1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mediator of RNA polymerase II transcription subunit 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_01248</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFD1"/>
    <dbReference type="SMR" id="C4YFD1"/>
    <dbReference type="PaxDb" id="5476-C4YFD1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01248"/>
    <dbReference type="HOGENOM" id="CLU_153329_0_0_1"/>
    <dbReference type="OMA" id="HNRINAN"/>
    <dbReference type="OrthoDB" id="203279at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.160">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009332">
        <property type="entry name" value="Med22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06179">
        <property type="entry name" value="Med22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ43017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="13534" checksum="E6DFE4DF4BBDEC44" modified="2009-07-28" version="1">MQPKSISLLQKIDSIIETIIVKFTNIFENLQDANKTTEILSMESLAMENNCIQIIRLCQDLISISRNLKEIWVLNSIKVTQEKFEWKQEEIDTMFTQFNLLTDKIAEFETDMNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFE1</accession>
    <name>C4YFE1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_01258</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFE1"/>
    <dbReference type="PaxDb" id="5476-C4YFE1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01258"/>
    <dbReference type="HOGENOM" id="CLU_022377_0_0_1"/>
    <dbReference type="OMA" id="FPACKYL"/>
    <dbReference type="OrthoDB" id="4937900at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ43027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="738" mass="86070" checksum="AA489996F1AA359C" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFK1</accession>
    <name>C4YFK1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bul1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_01319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFK1"/>
    <dbReference type="PaxDb" id="5476-C4YFK1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01319"/>
    <dbReference type="HOGENOM" id="CLU_022027_0_0_1"/>
    <dbReference type="OMA" id="GDPHDWC"/>
    <dbReference type="OrthoDB" id="420195at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039634">
        <property type="entry name" value="Bul1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022794">
        <property type="entry name" value="Bul1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007519">
        <property type="entry name" value="Bul1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904:SF1">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04426">
        <property type="entry name" value="Bul1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04425">
        <property type="entry name" value="Bul1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bul1 N-terminal" evidence="1">
        <location>
            <begin position="11"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Bul1 C-terminal" evidence="2">
        <location>
            <begin position="503"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ43082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="722" mass="82652" checksum="1F1E73F329210DF1" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFS8</accession>
    <name>C4YFS8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFS8"/>
    <dbReference type="PaxDb" id="5476-C4YFS8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00054"/>
    <dbReference type="HOGENOM" id="CLU_047845_4_0_1"/>
    <dbReference type="OMA" id="HYPCYIH"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17663">
        <property type="entry name" value="PFA-DSP_Oca6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000084">
        <property type="entry name" value="Tyrosine phospatase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF14">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE OCA6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ41867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="202" mass="23329" checksum="27BD0518FF9CB174" modified="2009-07-28" version="1">MSQIVPEIYVPPLRFSMVQPSLYRGAYPREVNFKFLETLQLKTIISLTPNPITKETDPELYNFAKENQIQLIHLECAQSGKGKKRGVPLDYEIAIQGLEYIIHNQYQPVYVHCYNGGQVTSLMVACLRKLQFWSAISIFNEFINFTTNITVNDRSFVDGFHGEIHINHDDKVDWLWVGVSKHVVGHHPKFQFIDKNKSMSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFW2</accession>
    <name>C4YFW2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pH-response regulator protein palF/RIM8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_01350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family. PalF/RIM8 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFW2"/>
    <dbReference type="PaxDb" id="5476-C4YFW2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01350"/>
    <dbReference type="HOGENOM" id="CLU_006001_1_0_1"/>
    <dbReference type="OMA" id="CLHGYAK"/>
    <dbReference type="OrthoDB" id="7785529at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF161">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALF_RIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="4">
        <location>
            <begin position="267"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="445"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="529"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="451"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ43113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="622" mass="69255" checksum="7EF9FEEAF1095D4B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG14</accession>
    <name>C4YG14_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RNA exonuclease 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_00129</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">3' to 5' exoribonuclease required for proper 3' end maturation of MRP RNA and of the U5L snRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YG14"/>
    <dbReference type="PaxDb" id="5476-C4YG14"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00129"/>
    <dbReference type="HOGENOM" id="CLU_022453_5_4_1"/>
    <dbReference type="OMA" id="IDCEMGF"/>
    <dbReference type="OrthoDB" id="3996471at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000031">
        <property type="entry name" value="RNA exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF118">
        <property type="entry name" value="RNA EXONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="13">
        <location>
            <begin position="242"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ41938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="406" mass="46780" checksum="2964A2F4B7279FB4" modified="2009-07-28" version="1">MDNNTQNKRSLDDSNGNDTKRPKQEDPKYILPKQVNTYPATLPERKKNIEYILNILTKKQPNITNPKLKAIDIEYEIAKKSTNATYKTVFRQEVFKLTKPTKSPSQLSPQQEHLKKLDQEAKELKILKEMVVSRKTLIAFGYIMEPPESIPNEKITRICNRCGTEFRLDQQLQPIVCEFHHGKKQRGKYICCMSNVDGQPCSKAKNHVYLLNTPEEKQALLPYQFTKELFTTTSTSTKSKSRVLGIDCEMGFTTKGFELMRITAIDYFTSKTVLDIFIKPIGEIVDFNTRYSGIHELTDDFLSWEQSMEKLGEIMDSETILIGHGLENDMNAMRLIHENIIDTSILFPNKWKTGPTRRWSLKDLAFEFLSRRIQTGEHDSCEDSIAAIDIVKYFVKKRLQSIGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG38</accession>
    <name>C4YG38_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_00155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YG38"/>
    <dbReference type="PaxDb" id="5476-C4YG38"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00155"/>
    <dbReference type="HOGENOM" id="CLU_122667_0_0_1"/>
    <dbReference type="OrthoDB" id="2684236at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ41962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="215" mass="24931" checksum="395C99DFE7C29056" modified="2009-07-28" version="1" fragment="single">MDPPRYNQVLDFIAILGQSDPTAFQSYNYSIQHEYPSIQRDKVTQINSKSLPTIADVVAHLKLLKAFGALKAKVLGTTSVIKDLNPAQHKYWQVFITNAVRRFIIFVSALRKYSCDTVSTVVREDIFFKVIKNKKFESMMSQIMPPLDVIMVWHAFLLNPKTFYDSFTRTDFIVFAKYPLPLDRIHGCIDNTTFEFNVPEIYRENYSSLLQPFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG79</accession>
    <name>C4YG79_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_00200</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="C4YG79"/>
    <dbReference type="PaxDb" id="5476-C4YG79"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00200"/>
    <dbReference type="HOGENOM" id="CLU_005768_0_0_1"/>
    <dbReference type="OMA" id="KYCGKPG"/>
    <dbReference type="OrthoDB" id="347657at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="STKc_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Serine/threonine-protein kinase ksg1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Serine/threonine-protein kinase PKH2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039046">
        <property type="entry name" value="PDPK1"/>
    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="240"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="107"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="162"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="550"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="611"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="660"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="796"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="990"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1076"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="550"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="618"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="802"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1076"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
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            <end position="1104"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1105"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
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            <begin position="1118"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ42003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1153" mass="128829" checksum="E4C5FF5A5009F3FA" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGB0</accession>
    <name>C4YGB0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_00231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="4081634at2759"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ42034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="126" mass="14435" checksum="4DAE1F83F82D87A1" modified="2009-07-28" version="1">MASASTTNLGIYSARQILLLAQLLHSDNINNVDKLTSLNENKIQNIIIQWKQHKINHLNSATINNKDSTIKLQTTAQLVELYKNLLKKYEVTNTEELANAAYFKRMNELEGIIEKDKQMFEDTLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGC4</accession>
    <name>C4YGC4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_00246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YGC4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00246"/>
    <dbReference type="HOGENOM" id="CLU_065389_3_0_1"/>
    <dbReference type="OMA" id="RNTWYFI"/>
    <dbReference type="OrthoDB" id="5537330at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052999">
        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180">
        <property type="entry name" value="CONSERVED MITOCHONDRIAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180:SF2">
        <property type="entry name" value="PEROXISOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ42048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38366" checksum="EC1C72D520D7E4A0" modified="2009-07-28" version="1">MTATTATTTTNPSITPELLLKLAYSYPNLQNSWYLIAVATLTQLNLSEEIPKVFHFALRQQLLEFQNDSSLLTNETMLKLAEDSISSSERFPDIYQTGVKLPDVLIPHTYSEKLPLNYKYHQGKDIRQTQQSIVDQIREVLLKISMFSGLPKSINSLLILKSVTPTALTNSNTDTNISLPKRKNIVEPIEENTTTNTQNVVDTIGGKISNGSIVVDQIVTNLIEGSEYWNTIYSNKLNIRIKKEMLRAYPDLWYFVYHHIYGPLISFTEILSPQKTSFSLIACMIPQDVNSQLKGHLKGAINNGATKEEVNNVIQLVFDICDSLNQTQLWKDGKQSVPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGC9</accession>
    <name>C4YGC9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGC9"/>
    <dbReference type="PaxDb" id="5476-C4YGC9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03105"/>
    <dbReference type="HOGENOM" id="CLU_067134_0_0_1"/>
    <dbReference type="OrthoDB" id="4092858at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021017">
        <property type="entry name" value="Mediator_Med2_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11214">
        <property type="entry name" value="Med2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="231" mass="26209" checksum="5F8775456071A60E" modified="2009-07-28" version="1">MPENLQTRLHNSLDEILKSSGYIFEIIGHNRKQSNVITSPNNELIQKSITQLLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKLDELKIKEEAAKKKEEEAKKAEEAKIAEEAKKAEEAKKAEEAKKAEEAAKKAETAPQKFDDFDDFIGFDINDNTNDEDMLSNMDYEDLKLDDKVPATTDNNLDMNNILENDESILDGLNMTLLDNGDHVNEEFDVDSFLNQFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGP3</accession>
    <name>C4YGP3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone deacetylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGP3"/>
    <dbReference type="PaxDb" id="5476-C4YGP3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03224"/>
    <dbReference type="HOGENOM" id="CLU_007727_7_6_1"/>
    <dbReference type="OMA" id="MSRFYTY"/>
    <dbReference type="OrthoDB" id="73273at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11680">
        <property type="entry name" value="HDAC_Hos1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000043">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="392" mass="44261" checksum="3CF6D25DC96D3A11" modified="2009-07-28" version="1">MATKRKVYITLSESATKVVDLLPSNKGRQSLVLGLIEAYKLIDLCDGTIDIYPAQTKDLTTYHDDEFVKHLMGPRTFLDKNFNKIDKAETDLTNVVIEENDLDEKYGLTFDCYPFPSLDLYVQLTAASSINAARKIVQQVKETNDQIIAVNWYGGRHHCHKSHAAGFCYVNDVVLSINILRKNLGSVFYLDLDLHHGDGVENAFKFSKKVATCSIHRYDIGFYPGTGSLKSSRENTYNIPTEKGLNDSSMLWIIKEIVAPLISNFGPRAIVIQCGCDGLALDTHKEWNMTIKGYRDSIDWILSHFSEIPIMLLGGGGYSHTETAKCWTYLTGSVLGVSDIDTWDILPEHKNLDAYEKDGFRFWTDHNSGPSKMKDHNSVEYLNDIKTHLLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGY2</accession>
    <name>C4YGY2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N6-L-threonylcarbamoyladenine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_03323</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGY2"/>
    <dbReference type="PaxDb" id="5476-C4YGY2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03323"/>
    <dbReference type="HOGENOM" id="CLU_023208_2_2_1"/>
    <dbReference type="OMA" id="HHRSWVV"/>
    <dbReference type="OrthoDB" id="10254073at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24132">
        <property type="entry name" value="ASKHA_NBD_OSGEP_like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000038">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000295">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03722">
        <property type="entry name" value="arch_KAE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="11">
        <location>
            <begin position="48"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="154"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ45014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="372" mass="41102" checksum="D5A8D5C466AB8742" modified="2009-07-28" version="1">MVVDLDKYLKPGKDHYLALGLEGSANKLGVGVIKHNKGPLSSTNRAEVLSNIRDTYITPPGEGFLPRDTARHHRNWVVRIIKQALATAKIAGKDIDVICFTQGPGMGAPLQSVVIAARTLAQLWNIPIVGVNHCVGHIEMGREITGAENPVVLYVSGGNTQVIAYSKQRYRIFGETLDIAIGNCLDRFARTLKIPNEPAPGYNIEQMAKKGKHLVPLPYTVKGMDLSMSGILAAIDSIAKEMFGKQQKKLIDEESGEPITAEDLCFSLQETLFSMLVEITERALAHVDSNQVLIVGGVGSNQRLQEMMKLMIQDRKNGQIYATDERFCIDNGIMIAHAGLLSYRTGQTNQLNNTVCTQRFRTNEVFVKWRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH06</accession>
    <name>C4YH06_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_03347</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YH06"/>
    <dbReference type="PaxDb" id="5476-C4YH06"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03347"/>
    <dbReference type="HOGENOM" id="CLU_309271_0_0_1"/>
    <dbReference type="OMA" id="WCLFDDE"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF24">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="546"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="264"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ45038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="950" mass="109178" checksum="081B50F4A6CA839E" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH81</accession>
    <name>C4YH81_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear rim protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_03425</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Member of a perinuclear network that controls recombination at multiple loci to maintain genome stability. Required for rDNA repeat stability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YH81"/>
    <dbReference type="PaxDb" id="5476-C4YH81"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03425"/>
    <dbReference type="HOGENOM" id="CLU_112962_0_0_1"/>
    <dbReference type="OMA" id="ESSIIMD"/>
    <dbReference type="OrthoDB" id="3363151at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043007">
        <property type="term" value="P:maintenance of rDNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018819">
        <property type="entry name" value="Nur1/Mug154"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293:SF1">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ45113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="212" mass="24982" checksum="3CE1333FB7299ECF" modified="2009-07-28" version="1" fragment="single">MSRKHIRKQSLVSQIQSFPFDLYLYLHELHASIDWDQYNYIIALPLGIISITIFSIIQSILNYYHYINKRSQNILFDSNYIQYENLKNNIIYNSSKQPQERTTSSIGDKEIVDVPFTTTVLWVLKSINWLIIFIGLFNAAKLFTKRKSYGLLYCKLKPKSKNVFKSSIERLSFIIEILAFLLKFFQNEQESEEEQESNSFNESSIIMDSTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH89</accession>
    <name>C4YH89_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="5">26S proteasome regulatory subunit RPN6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_03434</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YH89"/>
    <dbReference type="PaxDb" id="5476-C4YH89"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03434"/>
    <dbReference type="HOGENOM" id="CLU_029573_2_1_1"/>
    <dbReference type="OMA" id="ESKIYHA"/>
    <dbReference type="OrthoDB" id="1418352at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040780">
        <property type="entry name" value="Rpn6_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040773">
        <property type="entry name" value="Rpn6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18503">
        <property type="entry name" value="RPN6_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18055">
        <property type="entry name" value="RPN6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="166"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ45121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="364" mass="41635" checksum="F87AD89E180B11BB" modified="2009-07-28" version="1">MNLLNYSINCDFSINFSNSAKSKSPKIVKTLIEDFDKLSAKDEKSLDIQIDVTKSSMQWAIESKLSFLRQSLQLKLSDLLYQKKHHHEAIKIINELLREYKKLDDKSSLVEVQLLESKIYHALRNIPKAKAALTSARTSANSIYCPTILQAELDCQSGILNSEDKDYKTAFSYFYESFEGFNSQDDPRSIIVLKYMLLTKIMLNLIDDVNNILNNKNVIKYKSKDIDAMKSIAMAYSNRSLKEFENSLLTYANELRSDAIIKNHFNALYDNLLEQNLLKIIESYSCVELSHISKVIGLNLQQVEGKLSQMILDKVFYGVLDQGNGWLIIYDEPRKDAAYEASLELVKNLSNVVDLLYEKASSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH98</accession>
    <name>C4YH98_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_03443</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YH98"/>
    <dbReference type="SMR" id="C4YH98"/>
    <dbReference type="PaxDb" id="5476-C4YH98"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03443"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_3_1"/>
    <dbReference type="OMA" id="HKLHNNL"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000022">
        <property type="entry name" value="MFS drug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="551"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="77"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ45130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="581" mass="62142" checksum="984148D80D2F415E" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHC2</accession>
    <name>C4YHC2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase 9.5 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHC2"/>
    <dbReference type="SMR" id="C4YHC2"/>
    <dbReference type="PaxDb" id="5476-C4YHC2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03468"/>
    <dbReference type="HOGENOM" id="CLU_166990_1_0_1"/>
    <dbReference type="OMA" id="EKPAIFW"/>
    <dbReference type="OrthoDB" id="2093409at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd22903">
        <property type="entry name" value="NI9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039961">
        <property type="entry name" value="Nuo9.5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9718" checksum="D7B35938638491C7" modified="2009-07-28" version="1">MSEEKVWGDKPVYFKQPFRWIRYHAHVNPALFVSVALGVSAPLVLLLTPLRRKYLYADHEPVPQVYPLPQRPRDKNLTGFDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHC5</accession>
    <name>C4YHC5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SRPBCC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_03471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHC5"/>
    <dbReference type="SMR" id="C4YHC5"/>
    <dbReference type="PaxDb" id="5476-C4YHC5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03471"/>
    <dbReference type="HOGENOM" id="CLU_069867_4_1_1"/>
    <dbReference type="OMA" id="SYPEWNP"/>
    <dbReference type="OrthoDB" id="509124at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd07822">
        <property type="entry name" value="SRPBCC_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36166">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36166:SF1">
        <property type="entry name" value="SRPBCC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ45157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="17849" checksum="999274E0DBD18A3F" modified="2010-10-05" version="1">MKTIESNIIINAKPEKVRSFFLNYQNYPSWNPFLVKFAKYTNKEDPELKVGDELQIDLKLKGFNHTSTMYPKVLQNNEDGLVWRGQLLSTWVFGGTHSFKYELIDGDKTLFTQKEEFTGILVYVFYLFGLFKKTQESFINLNEVLKDQVENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHE9</accession>
    <name>C4YHE9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_03495</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHE9"/>
    <dbReference type="SMR" id="C4YHE9"/>
    <dbReference type="PaxDb" id="5476-C4YHE9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03495"/>
    <dbReference type="HOGENOM" id="CLU_143122_2_1_1"/>
    <dbReference type="OMA" id="YCCRRMF"/>
    <dbReference type="OrthoDB" id="10258858at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ45181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="72" mass="8584" checksum="9A47C205340D2407" modified="2009-07-28" version="1">MIIPIRCFSCGKVVGDKWQTYLDYLQDETLSEGDALDKLKLKRYCCRRMVLTHVDLIEKFLRYNPLEKKDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHG2</accession>
    <name>C4YHG2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Crh-like protein</fullName>
            <ecNumber evidence="18">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CAWG_03508</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="18"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHG2"/>
    <dbReference type="SMR" id="C4YHG2"/>
    <dbReference type="PaxDb" id="5476-C4YHG2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03508"/>
    <dbReference type="HOGENOM" id="CLU_027506_2_2_1"/>
    <dbReference type="OMA" id="DDDNWEG"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000162">
        <property type="entry name" value="Glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0134">Cell wall</keyword>
    <keyword evidence="16" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12 20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="10 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 22" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946646" description="Crh-like protein" evidence="22">
        <location>
            <begin position="22"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="23">
        <location>
            <begin position="28"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="281"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="362"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="286"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="363"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="19">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="19">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="24"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EEQ45194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="453" mass="46733" checksum="39B0F26D12C819AB" modified="2010-10-05" version="1">MKFTTLATIASTLLFAANANADTCNPLKSSDCSPVPALGSSFLEKFDNGLGPHFESLKKQGTIDSGSNGLSLTMKKRFDNPSFKSNFYIMFGRVEVVLKGAEGKGIVSSFYLQSDDLDEIDIEMFGGDPYQWQSNYFIKGNTATYDRGGYHDIANPLKDYHTYVIDWTKDAVTWSVDGSVIRTIPKDNAQGFPQSPMAIYAGIWAGGDPSNQPGTIDWAGGITDYSQAPFTMGIKSVLVADYSSGKQYSYSDQSGSWESIKADGGKVNGRYDQAQDDIKKLESGQSVDSNDSSSSPSASSSDSSSTSSASSSSSSSSPSSTTSSSSSSSSSSSSSSSSSSEKSNAVPSASVIVFIGTKGGDKTTVTSSSGVSVPTSASVSTAAGTTSGSANSAPASAASSTASTVFISTGDAAPSSSASEKPSVSTTENNGAVSVAKTTSLFGFVALIGFLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHT9</accession>
    <name>C4YHT9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHT9"/>
    <dbReference type="PaxDb" id="5476-C4YHT9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03641"/>
    <dbReference type="HOGENOM" id="CLU_744168_0_0_1"/>
    <dbReference type="OMA" id="ALINHFY"/>
    <dbReference type="OrthoDB" id="4090091at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="418" mass="48533" checksum="F4E3941ED8411DD0" modified="2009-07-28" version="1">MVLKNSKWDKKAKYKYLKKHNILPTKTEKDNANTTPSTKWSSKKKPIDNHTTGVTLEDSDDEWDSDIDDALINHFYPQLSENDELTIEQKKKIKSQILANLDKDNKKEEKEKEKEGKESIENTIEDELDGIYLGSDDTNKLKELKPNINGADSKFDLEEFINNLDIKPKKNKRKLLHNKISDNFLEEYGLSSYQELNRNVDDYNSIYEKKQKELLTRNNLNNIPIEKLDGFIIGESSLIDKINTTDKSKNIKKSNIQILTNDEKQKDIDRQKLIEQENFYRQIKNKFNNNDDNVNKSNKLGKILEINNFDNNDVDQLAYLNNKILQNDNSKATTTLDNDLDLLLGISSDGKDDVDKVESNVKQQDDNFDTFINKLAINDKDETFKNEQHQSKLSFDKVNKKQNQNDAKDLDFLDDLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHZ1</accession>
    <name>C4YHZ1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein FYV8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHZ1"/>
    <dbReference type="PaxDb" id="5476-C4YHZ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03697"/>
    <dbReference type="HOGENOM" id="CLU_015976_0_0_1"/>
    <dbReference type="OMA" id="GIQTWIN"/>
    <dbReference type="OrthoDB" id="4081733at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="730"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="766"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="901" mass="100767" checksum="9587887333FC3048" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI43</accession>
    <name>C4YI43_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Peroxin-10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CAWG_03751</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI43"/>
    <dbReference type="PaxDb" id="5476-C4YI43"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03751"/>
    <dbReference type="HOGENOM" id="CLU_1713053_0_0_1"/>
    <dbReference type="OMA" id="IRDHPEC"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16527">
        <property type="entry name" value="RING-HC_PEX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000617">
        <property type="entry name" value="Peroxin 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF0">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944239" description="RING-type E3 ubiquitin transferase" evidence="20">
        <location>
            <begin position="25"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="21">
        <location>
            <begin position="79"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EEQ45425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="129" mass="14703" checksum="BF0E97480B4BAFA0" modified="2009-07-28" version="1">MQGRNYSLLGGIIVLQFIVKSLVGMKSKEKKQTEDTTDDAKIRSINQLSQLSENYSAEYIIDLSDEKQLPYLPEASRSCMLCLSPMVNPSAANCGHLFCWDCIVDWIREHPECPLCRQQCLEQHLLPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI53</accession>
    <name>C4YI53_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent RNA helicase SUB2</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ATP-dependent RNA helicase sub2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CAWG_03761</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 also plays a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the DEAD box helicase family. DECD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI53"/>
    <dbReference type="SMR" id="C4YI53"/>
    <dbReference type="PaxDb" id="5476-C4YI53"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03761"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="OMA" id="YAHVEPK"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17950">
        <property type="entry name" value="DEADc_DDX39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000809">
        <property type="entry name" value="ATP-dependent RNA helicase SUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000111">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 24" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="23">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="21">
        <location>
            <begin position="80"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="22">
        <location>
            <begin position="267"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="19">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00040402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EEQ45435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="433" mass="49146" checksum="65EA023BC86CB58F" modified="2009-07-28" version="1">MSHEGQEELLDYSDSEEIAVSTTTQASGEAQSNDKESDKKGSYVGIHATGFRDFLLKPELLRAIGDCGFEHPSEVQQVCIPQSILGTDVLCQAKSGLGKTAVFVLSTLQQLDPVPGEISTLVICHTRELAYQIRNEYARFSKYMPDVKTDVFYGGTPIKRDIEKLKNKDTCPHIVVATPGRLHALVEEKAIRLNNVKSFVIDECDKVLESIDMRRDVQDIFRATPHQKQVMMFSATLSQDIRPVCKKFMQNPLEIYVDDEAKLTLHGLQQYYIKLDEKEKNRKLSDLLDSLEFNQVIIFVKSTRRANELNKLLCACNFPSIAVHSGLPQEERIERYRSFKEFNKRICVSTDVFGRGIDIERINLAINYDLPNEADQYLHRVGRAGRFGTKGLAVSFVSSKEDEEVLEKIQSRFDVKITEFPEEGVDPSTYMNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI96</accession>
    <name>C4YI96_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="9">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_04168</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="9"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI96"/>
    <dbReference type="PaxDb" id="5476-C4YI96"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04168"/>
    <dbReference type="HOGENOM" id="CLU_000335_0_1_1"/>
    <dbReference type="OMA" id="VYGYQSH"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001076">
        <property type="entry name" value="ATP-dependent DNA helicase MER3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000012">
        <property type="entry name" value="DEAD/DEAH box DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052247">
        <property type="entry name" value="Meiotic_Crossover_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835:SF3">
        <property type="entry name" value="HELICASE FOR MEIOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835">
        <property type="entry name" value="HFM1, ATP DEPENDENT DNA HELICASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="7"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="221"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="891"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="897"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ45831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1091" mass="123152" checksum="CC9C985333A5897B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIA5</accession>
    <name>C4YIA5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_04177</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIA5"/>
    <dbReference type="PaxDb" id="5476-C4YIA5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04177"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_34_1"/>
    <dbReference type="OMA" id="PLDSQWV"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002379">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit beta, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="187"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="228"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="274"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="424"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ45840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="457" mass="50224" checksum="6593DE7E2D3409FD" modified="2009-07-28" version="1">MSDYLAQSLIQSPSSISQQEQQSLLSSITGQIDTARNEAKVLYTEILSVKRRTQDATIQAISQNVNQIPKNSCNLTLYNTLRGHQNKIAKLCWSSDSSKILSASQDGFMIIWDAVTGFKKHAIQLNNPWVLTCSYSPNEKLVASAGLDNNCTIYKIKPDTSNFPVTEERNGTYQMQGNFYQSIQSIFKGHTAYISECEFIGNNSIVTASGDMTCALWDLTKGTKSRDFVEHSGDVLCLSTFPQNILSANLFVSGSSDGSAKIWDLRSPTPTQSFGISNSDVNSVKVFPDGNAFATGSDDGSIRLFDLRSDCELGHYSLSSELRNKQNLLHLTIPSPVDERYMKRFGNTTSQTYDEQSTSLLHSNGSSSGNIDQYSVNSLQSVIENQGVFSLDFGKSGRFLYSCYSEYGCVVWDTLKSEIVGIIGSEHLNKINQVSVSPDGVALATGSWDATIKVWSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIM9</accession>
    <name>C4YIM9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_04305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YIM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIM9"/>
    <dbReference type="PaxDb" id="5476-C4YIM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04305"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_1"/>
    <dbReference type="OMA" id="RHVKFIP"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08247">
        <property type="entry name" value="AST1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="22"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ45964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="349" mass="39033" checksum="886CC03E376BE4CC" modified="2009-07-28" version="1">MTKLTYKRYGFKNGGSPLEIITDSFDFPTDAQGNFIIPKNKILIKIYYASLNPVDYKLKKITYFPPFSLHGIGKDYSGEIVGLGSNVKNFKVGEFVQGFHPGVITDDGTFSQYLLIDTKGLFKTEIATVPQNISLEQAAAWPLVLGTAIKVISDLPIKGKKILVFGGATSVGRYLVQLLQAEKAGEIVVSCSPRSQELVTELGATKIINYRENVLNQVLENVKDKPFDYIFDTWGGNELFPHLKQILVKNGTYHTIVGDDPHSFFTGTSKSFFRTFLSWLHLLGYSYQYVLLGAGGTGWINKAREYVANDDVQIFIDKIYKFEDLNDAIEYNKTGTAQGKLIINVKDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIN8</accession>
    <name>C4YIN8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_04314</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIN8"/>
    <dbReference type="PaxDb" id="5476-C4YIN8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04314"/>
    <dbReference type="HOGENOM" id="CLU_014853_3_0_1"/>
    <dbReference type="OMA" id="RASECQQ"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="10">
        <location>
            <begin position="195"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="843"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="854"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ45973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="889" mass="100488" checksum="37C58BB62325549E" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIU2</accession>
    <name>C4YIU2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ46027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIU2"/>
    <dbReference type="PaxDb" id="5476-C4YIU2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04371"/>
    <dbReference type="HOGENOM" id="CLU_131284_0_0_1"/>
    <dbReference type="OrthoDB" id="4084460at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="132" mass="15032" checksum="8058F47813F949DC" modified="2009-07-28" version="1">MRMAPKSPTRPRPRSRNQKQKQKQDYQPTSAITLESSNESFSSEIIIDKSNPIHKNIYCVGLLLNSYLDFNNDQLNLKLKVQETSSEEEEEATEDLIKEFPLSIVSLETTVVKSVLAGEVGEEEEEEQAQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ20</accession>
    <name>C4YJ20_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 11">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_03832</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 11"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ20"/>
    <dbReference type="PaxDb" id="5476-C4YJ20"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03832"/>
    <dbReference type="HOGENOM" id="CLU_025694_1_1_1"/>
    <dbReference type="OMA" id="GMFQPPY"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007117">
        <property type="term" value="P:budding cell bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010570">
        <property type="term" value="P:regulation of filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946533" description="Mannan endo-1,6-alpha-mannosidase" evidence="13">
        <location>
            <begin position="22"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ45504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="451" mass="50003" checksum="E0627EB60DF4B7CD" modified="2009-07-28" version="1">MVSLQQLTISILLLFTASVQSLDINVDDKDSICSAAKYVVQGIWNYYEGLKYGGTVGMFAPPNYWWNAGEAFGGLVDFYTYCQSDNSTLEKLIYNGMYHQAGENYNYIPSNQSMTEGNDDQGVWGMAIMEAVERNFTEPESHSWLEMVQAVFNTMNARWDADNCGGGLRWQIFTWNSGYDYKNSISNGCLFHLAARLARYTGNSSVYVDTAEKVWKWMEDVGFLTEEDNGDVRIYDGAKITNNCSSVTDLRWSYTYGVFMAGCAYLYNFTGDDVWLTRTNEIVQASLSYFFANKIMQETTCQPQNKCNNDQRSFRCLFSRCLGLTTQLAPETKDKIREVLEASAEGAAKSCSGGSDGVTCGENWAIDKWDGVYGLGEQTSALEVMMALIVEPPLSVKTGGTNRTDYSAGTNSEDNANKNELTITGKDKAGAGVLTAIVLAVILGGAIWMIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ79</accession>
    <name>C4YJ79_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_03892</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ79"/>
    <dbReference type="PaxDb" id="5476-C4YJ79"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03892"/>
    <dbReference type="HOGENOM" id="CLU_003094_0_1_1"/>
    <dbReference type="OMA" id="FSFVQSY"/>
    <dbReference type="OrthoDB" id="10259024at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019515">
        <property type="entry name" value="VPS54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10475">
        <property type="entry name" value="Vps54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 N-terminal" evidence="10">
        <location>
            <begin position="284"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 C-terminal" evidence="9">
        <location>
            <begin position="822"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="552"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="785"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="26"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="552"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ45563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="978" mass="109433" checksum="23A349D2CE1041F3" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJC4</accession>
    <name>C4YJC4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA m(6)A methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.348</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_03937</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55584"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12417"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="2.1.1.348"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MT-A70-like family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.348" evidence="1"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJC4"/>
    <dbReference type="PaxDb" id="5476-C4YJC4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03937"/>
    <dbReference type="HOGENOM" id="CLU_018702_4_1_1"/>
    <dbReference type="OMA" id="PIINNHT"/>
    <dbReference type="OrthoDB" id="10262526at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001734">
        <property type="term" value="F:mRNA m(6)A methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF7">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ45608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="543" mass="62634" checksum="7BFE4ACF9C65F2A2" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJX1</accession>
    <name>C4YJX1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L21-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_04142</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJX1"/>
    <dbReference type="SMR" id="C4YJX1"/>
    <dbReference type="PaxDb" id="5476-C4YJX1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04142"/>
    <dbReference type="HOGENOM" id="CLU_103610_0_0_1"/>
    <dbReference type="OMA" id="INYGDYV"/>
    <dbReference type="OrthoDB" id="1539250at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3260:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ45805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="160" mass="18013" checksum="9619C57CAFCE5F51" modified="2009-07-28" version="1">MGKSRGYRSGTRYAFQRDFKKHGAIPLSTYLKVYKVGDIVDIKANGSIQKGMPHKYYHGKTGIVYNVTKSSVGVIINKVVGNRYIEKRVNLRVEHVKHSACRQEFLNRVKSNAAKKREAKANGETVYLKRQAAKPRGSRIISTEGNIPQTLAPVAYETFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJX7</accession>
    <name>C4YJX7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amine oxidase</fullName>
            <ecNumber evidence="11">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_05769</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="11">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10 11">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="11"/>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJX7"/>
    <dbReference type="PaxDb" id="5476-C4YJX7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05769"/>
    <dbReference type="HOGENOM" id="CLU_011500_3_1_1"/>
    <dbReference type="OMA" id="VRNDPWI"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000011">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000017">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049947">
        <property type="entry name" value="Cu_Am_Ox_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF33">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00766">
        <property type="entry name" value="CUDAOXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01165">
        <property type="entry name" value="COPPER_AMINE_OXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="12">
        <location>
            <begin position="241"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="9">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="10">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ47206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="667" mass="75695" checksum="8726C6583AEF11ED" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJZ5</accession>
    <name>C4YJZ5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cerevisin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_05787</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJZ5"/>
    <dbReference type="PaxDb" id="5476-C4YJZ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05787"/>
    <dbReference type="HOGENOM" id="CLU_011263_1_4_1"/>
    <dbReference type="OMA" id="CEYSPAR"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000011">
        <property type="entry name" value="Vacuolar protease B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Inhibitor I9" evidence="8">
        <location>
            <begin position="77"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="7">
        <location>
            <begin position="191"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ47224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="50256" checksum="F1F36D964A3F28D3" modified="2009-07-28" version="1">MKVTNVISFATVASTAVSLVIPDITSFFSSFNQILIPHHQQAPLINQDAHLPSDDNQPDTKTGILSNPLNKIIPNHYIVVLKDDLSQAQFLQHQNWVQNEHVSISSCKSNVNKKPLEFFQIDNFVRGYTGFFTDDLINKILELPEVAFVERDSIFHTVEFDIQKDATWGISRVSHRENIDDGKYLFDNDGGKGVTAYVIDTGIKVGHPDFEDRAQWGASIAFPNIKQDYNGHGTHCAGTIGSKTYGIAKNVNLVAVGVMNMLGAGSTSDIIKGLEFVVKSHQDDVRAKKKGFKGSTVNMSIGGGISDALDLAVNAGTKAGLHISVAAGNDNADACQYSPARATGPITIGASNIRDEKASFSNWGSCVDLFAPGEDIESTFIWSDTTVMSGTSMASPHIAGLLSYYLSLQPDVTSEFYTQAIEPADLKNKLIKYGTKGVLTGLDSVSPNILAFNGAGGNLTDFWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK40</accession>
    <name>C4YK40_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK40"/>
    <dbReference type="PaxDb" id="5476-C4YK40"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05835"/>
    <dbReference type="HOGENOM" id="CLU_376415_0_0_1"/>
    <dbReference type="OMA" id="RQEINMF"/>
    <dbReference type="OrthoDB" id="4087712at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="737" mass="83683" checksum="372A060FBAEA6441" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKZ3</accession>
    <name>C4YKZ3_CANAW</name>
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        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_01506</name>
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        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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                <person name="Cuomo C.A."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">WO-1</strain>
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        <property type="component" value="Chromosome R"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="245" mass="29111" checksum="AA1D3E44782D623A" modified="2009-07-28" version="1">MSEELDRILSIEESAINRNKEIDRILQCSPYDYYSILEINPLLSTTTAQELSTIIKKLYRKKSLLIHPDKSDNPKAPEAFDLLKKSEHILTSTEESDIKEIEHLYSIYQAYKPKPEQKQKQIDDHEQQYSQLEFNDPINIEIRSKVKQILIDEINELNLNKLIKQTELLRKDEMKQKIELEKKIKRQLDKNWEDERDLRVRNWRKYSNKIERKQKRQQEGQQQASSSSSSSGKVSKKKKKKNVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL04</accession>
    <name>C4YL04_CANAW</name>
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        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_01518</name>
    </gene>
    <organism evidence="6 7">
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        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
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                <person name="Shah P."/>
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                <person name="Staggs R."/>
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                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
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                <person name="Heitman J."/>
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                <person name="Lorenz M.C."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">WO-1</strain>
        </source>
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        <property type="component" value="Chromosome R"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="342"/>
        </location>
    </feature>
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    </feature>
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    </feature>
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        </location>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ43285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="768" mass="85822" checksum="BBF04DCC229F423C" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL96</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL96"/>
    <dbReference type="PaxDb" id="5476-C4YL96"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01613"/>
    <dbReference type="HOGENOM" id="CLU_1348755_0_0_1"/>
    <dbReference type="OMA" id="YKNSTTM"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946595" evidence="1">
        <location>
            <begin position="21"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="191" mass="19072" checksum="0B817839F53E0D46" modified="2009-07-28" version="1">MKFTNLICSFTLLIIPTVMADDASSDTTIINTITITKTLYTPEESSSLLSVQLESEASVASVASASAASIASVASEASAASLASELSALAKVTEVKADVINNYNATINSTLSSSTIAPKISSSSSSSSSKKHESITSVITSSTKDNASAAVTTKTGSATSKAGAAAMAGPVPILTNSIFTAGLLALAAVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLG2</accession>
    <name>C4YLG2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_01680</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLG2"/>
    <dbReference type="PaxDb" id="5476-C4YLG2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01680"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_5_1"/>
    <dbReference type="OMA" id="MAIIVSC"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="500"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="84"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ43443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="562" mass="61703" checksum="BAC21572989B9036" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLI0</accession>
    <name>C4YLI0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mitochondrial escape protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_01698</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the YME2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLI0"/>
    <dbReference type="PaxDb" id="5476-C4YLI0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01698"/>
    <dbReference type="HOGENOM" id="CLU_007861_1_0_1"/>
    <dbReference type="OMA" id="FQFFRPY"/>
    <dbReference type="OrthoDB" id="10267654at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12433">
        <property type="entry name" value="RRM_Yme2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018850">
        <property type="entry name" value="Mt_escape_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039627">
        <property type="entry name" value="Yme2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034260">
        <property type="entry name" value="Yme2_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198:SF2">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10443">
        <property type="entry name" value="RNA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Mitochondrial escape protein 2 C-terminal" evidence="12">
        <location>
            <begin position="390"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ43461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="867" mass="99366" checksum="8996E363664AA13E" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLL6</accession>
    <name>C4YLL6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLL6"/>
    <dbReference type="PaxDb" id="5476-C4YLL6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01735"/>
    <dbReference type="HOGENOM" id="CLU_071871_0_0_1"/>
    <dbReference type="OMA" id="QHSESDP"/>
    <dbReference type="OrthoDB" id="21418at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029196">
        <property type="entry name" value="HAPSTR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645:SF1">
        <property type="entry name" value="YALI0F12243P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15251">
        <property type="entry name" value="TAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="242" mass="27228" checksum="4136DC2346B07DB0" modified="2009-07-28" version="1">MDLSNLSNTLPSDNTRPGNTTAVHSSTPTSNINQDLTNHFKDAAKSVASLYNISLNNTVDNNVNNRNIKTEFANAAKAVASLYKLGQSSQQTSYTKGYLQCLDDLLAVLTNNEDIEDWVLTRRIELMNHMTNPNSKPPSSGDASQHSESDPFSIPHDYEFTFNSDMKPPTHFRPSMPPLSVQHNSKQRASIGNHHLKHSKKIPFSEDSIMVDDSDNEDKEVKQQQLYPKYLKESPLKKKRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLL9</accession>
    <name>C4YLL9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_01738</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLL9"/>
    <dbReference type="PaxDb" id="5476-C4YLL9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01738"/>
    <dbReference type="HOGENOM" id="CLU_046293_1_0_1"/>
    <dbReference type="OMA" id="KEWKFIP"/>
    <dbReference type="OrthoDB" id="359154at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_uL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22682">
        <property type="entry name" value="Ribosomal_uL24m-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KOW" evidence="3">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ43500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="338" mass="38924" checksum="69987DAE8398EF82" modified="2009-07-28" version="1">MSWVTRTFRFERNVNKYPENLRKHFQKNKEITNLPSFKNFFPTTLPRSQQKTNVEAGIMEGDLAYVTTGPHKGKIAEVLSYSPEYDAVSLSNISSKKLIPKIFWPEGQTSHVFDFPDYIPRNQVRVVGKDKDENGNVSYVVAEDIELRDKYYDDRFKKFMPRRFVKYHENIEFPWPEPQALEDGPLSTPENVAMERTFEFNSIAKSGIPKAALAQLRNPYSKHKKKTLSGLQVAKLNGPEMPLTIEQKIWIAKNQEKQAETKPEYKPLSDEVQEFIGKKMAEHLNKIESPELRYHLDVLSNSVSHDFQKTLDIIEKTKSQGDSELTNSTGESSDKGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLW6</accession>
    <name>C4YLW6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_01838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLW6"/>
    <dbReference type="PaxDb" id="5476-C4YLW6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01838"/>
    <dbReference type="HOGENOM" id="CLU_2320095_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="99" mass="11588" checksum="D1600F65271057C6" modified="2009-07-28" version="1">MFSFRDETIHINVDLYCKKNKTKKKRESKSNLLVPKNKRFPSGLPVIISMFRFVRLIQAPQGVYYKSRVIEPCICEGSGVWGSFTITSRKNWINVRVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLZ4</accession>
    <name>C4YLZ4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxyanthranilate 3,4-dioxygenase</fullName>
            <ecNumber evidence="9">1.13.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyanthranilate oxygenase</fullName>
            <shortName evidence="9">3-HAO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyanthranilic acid dioxygenase</fullName>
            <shortName evidence="9">HAD</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Biosynthesis of nicotinic acid protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BNA1</name>
        <name evidence="10" type="ORF">CAWG_01868</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:17953"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:77612"/>
            <dbReference type="EC" id="1.13.11.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 3-HAO family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.6" evidence="9"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLZ4"/>
    <dbReference type="SMR" id="C4YLZ4"/>
    <dbReference type="PaxDb" id="5476-C4YLZ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01868"/>
    <dbReference type="HOGENOM" id="CLU_095765_0_0_1"/>
    <dbReference type="OMA" id="KPPVGNQ"/>
    <dbReference type="OrthoDB" id="204928at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000334">
        <property type="term" value="F:3-hydroxyanthranilate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06123">
        <property type="entry name" value="cupin_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000093">
        <property type="entry name" value="3-hydroxyanthranilate 3,4-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00825">
        <property type="entry name" value="3_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010329">
        <property type="entry name" value="3hydroanth_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03037">
        <property type="entry name" value="anthran_nbaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497:SF1">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06052">
        <property type="entry name" value="3-HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ43625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="171" mass="19545" checksum="EAADB3DA38113136" modified="2009-07-28" version="1">MVLGQPINIIKWIEENGDLLKPPVNNFCLHRGGFTIMIVGGPNERSDYHINQTPEYFYQFKGTMCLKVVDDGEFKDIFINEGDSFLLPPNVPHNPCRYENTIGIVVEQDRPAGVNDKVRWYCQKCQTVIHEVEFYLTDLGTQIKEAIVKFDADLDARTCKNCGTVNSSRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM49</accession>
    <name>C4YM49_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Target of rapamycin complex subunit LST8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_01924</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM49"/>
    <dbReference type="SMR" id="C4YM49"/>
    <dbReference type="PaxDb" id="5476-C4YM49"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01924"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_5_1"/>
    <dbReference type="OMA" id="VQRNYKH"/>
    <dbReference type="OrthoDB" id="400at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000339">
        <property type="entry name" value="WD-repeat protein pop3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF0">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="96"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="137"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="228"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="271"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ43680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="328" mass="36540" checksum="302E236BE394D223" modified="2010-10-05" version="1">MSVILASAGYDHTIRFWDALTGVCSRTIQHPESQVNRLEITSDKRFLAAAGNLYVKLYDIRQTGNSGNGANGTTNTSASTSSSNQNNSNNNPVMTFEGHKNNVTSLQFQADNKWMVTSSEDGTVKVWDVRSPSVQRNYKHQCPVNEVVIHPNQGELISCDQDGNIRVWDLGENSCTHHLIPEDDVPINSLSVASDGSMLVAGNNKGNCYVWKMQNQRDATVLTPVTKFRSHSKYITRVLLSTDMKHLATCSADHTARIWSTEQNFNLETTLQGHQRWVWDCAFSADSAYLVTACSDHYVRLWDLSNSETVRQYNGHHKGAVCVALNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMA7</accession>
    <name>C4YMA7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_01986</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMA7"/>
    <dbReference type="PaxDb" id="5476-C4YMA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01986"/>
    <dbReference type="HOGENOM" id="CLU_010365_4_0_1"/>
    <dbReference type="OMA" id="GWYMYYF"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="17">
        <location>
            <begin position="378"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ43738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="708" mass="81438" checksum="12B470F5E782A7EE" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YME1</accession>
    <name>C4YME1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YME1"/>
    <dbReference type="PaxDb" id="5476-C4YME1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02020"/>
    <dbReference type="HOGENOM" id="CLU_308820_0_0_1"/>
    <dbReference type="OMA" id="ENTYEFA"/>
    <dbReference type="OrthoDB" id="4089164at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19327">
        <property type="entry name" value="GOLGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19327:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="965"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="397"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="657"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="897"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="972"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="986"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ43772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1040" mass="118147" checksum="C71D15710F16F39B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YME4</accession>
    <name>C4YME4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Long-chain-alcohol oxidase</fullName>
            <ecNumber evidence="16">1.1.3.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAWG_02023</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Long-chain fatty alcohol oxidase involved in the omega-oxidation pathway of lipid degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>a long-chain primary fatty alcohol + O2 = a long-chain fatty aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:22756"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17176"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="EC" id="1.1.3.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a primary alcohol + O2 = an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:19829"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="EC" id="1.1.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Energy metabolism; methane degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 16">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.20" evidence="16"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YME4"/>
    <dbReference type="PaxDb" id="5476-C4YME4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02023"/>
    <dbReference type="HOGENOM" id="CLU_008878_3_1_1"/>
    <dbReference type="OMA" id="RNVKGCW"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="UniPathway" id="UPA00147"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047639">
        <property type="term" value="F:alcohol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046577">
        <property type="term" value="F:long-chain-alcohol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046188">
        <property type="term" value="P:methane catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015945">
        <property type="term" value="P:methanol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012400">
        <property type="entry name" value="Long_Oxdase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056:SF12">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028937">
        <property type="entry name" value="Lg_Ch_AO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0485">Methanol utilization</keyword>
    <keyword evidence="12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="18">
        <location>
            <begin position="242"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="19">
        <location>
            <begin position="541"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR028937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR028937-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEQ43775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="704" mass="77497" checksum="8CBDF8EC437A34F4" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YME7</accession>
    <name>C4YME7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Quinate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_02026</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YME7"/>
    <dbReference type="PaxDb" id="5476-C4YME7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02026"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_2_1"/>
    <dbReference type="OMA" id="HITRCIA"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF34">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="55"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ43778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="280" mass="30616" checksum="52A7AAF148B04964" modified="2009-07-28" version="1">MLIDNKKLNLLETQTTNTEKELQEVDGEDEISYDTEDLSAPPTPSTIYNWRIVIIAITASFAAVIVGYDAGFIGGTVSLASFQGEFKMNELSPSQKTEISSNVVSVFQAGAFFGALFFYPIGEIWGRKLGLILSAFLLVFGAGISLEAKHSTGLASIYAGRVITGLGVGGCSGMAPIYISECSPAKIRGKLVGMWEMSWQIGGIVGYWINYGVLQNLPPSRKQWLIPFAIQLIPSGVFFIGTIFIPESPRFLVYKGQIEKAKVNLSQFEKYPYRPSILSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMW6</accession>
    <name>C4YMW6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_02203</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000309">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02203"/>
    <dbReference type="HOGENOM" id="CLU_005966_1_0_1"/>
    <dbReference type="OMA" id="ARCADHH"/>
    <dbReference type="OrthoDB" id="10023235at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031332">
        <property type="term" value="C:RNAi effector complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Serine/threonine-protein kinase 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000072">
        <property type="entry name" value="Transcription factor (Snd1/p100), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000109">
        <property type="entry name" value="Transcription factor (Snd1/p100), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016685">
        <property type="entry name" value="Silence_cplx_Nase-comp_TudorSN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF2">
        <property type="entry name" value="STAPHYLOCOCCAL NUCLEASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017179">
        <property type="entry name" value="RISC-Tudor-SN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TNase-like" evidence="7">
        <location>
            <begin position="149"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="7">
        <location>
            <begin position="313"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="6">
        <location>
            <begin position="712"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="901" mass="100020" checksum="F2CF7C7EA12A34C1" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMY5</accession>
    <name>C4YMY5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMY5"/>
    <dbReference type="PaxDb" id="5476-C4YMY5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02222"/>
    <dbReference type="HOGENOM" id="CLU_045411_1_0_1"/>
    <dbReference type="OMA" id="LYIHSRT"/>
    <dbReference type="OrthoDB" id="438224at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000071">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420:SF1">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="51606" checksum="93CBE1C97BF99EA3" modified="2009-07-28" version="1">MVVKKNRFCPAPAPRPHFYFFLLTSSIQGKNLFHNISITTYQICPRPRPRPLTYLMSCDSPIIVSLNDLKTDEGYPGLKDEILEKAFGPNSLGIIIIKDLPIQFVELRKKVLISASKLANLPTDQLKSLECEKNYWLTGWSCGKEKLRQTNNNNNNNNNYSIPDDKKGSFYINCSFYKDDKLESPPQELIDKFPNHLTYTMKNIWPPEDENSGLIGFKQNLKNLCNLIISISESVAINCDKYIKSHYPNDYPSNDYLTKIVQNSTCTKARLLHYFPNYNYNYNYNNKEEEKEEEEDNNNLTDLEAEALSDDNWCGEHLDHSCLTGLTSALYIDESKGLNPHHAAAAAAVVLDNSSPDLDPDSGLYIKNRQNDKIIKINIPHDCLAFQSGSTLQQVSKNKFKAVPHFVKSGNNNKGKSIARNTLAVFIQPNLDEMVNEMENFAQYSDRILKSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN02</accession>
    <name>C4YN02_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_02240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN02"/>
    <dbReference type="PaxDb" id="5476-C4YN02"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02240"/>
    <dbReference type="HOGENOM" id="CLU_069851_0_0_1"/>
    <dbReference type="OMA" id="NFCPLHD"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16489">
        <property type="entry name" value="mRING-CH-C4HC2H_ZNRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164:SF29">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="17"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="313"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="272"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="40859" checksum="5FAD57F3FAECE7C5" modified="2009-07-28" version="1">MSIPINLNDDLFEWQDDAEVTSCFICDRPYNIFFNRRHHCRKCGKVVCGDCSSQFISYFPNTPIVTEPHVVFPQYSKPHTKYRTCDQCVEEILMIRRALFNSDTRSHTTTIASSVETDHEDNNNGAVSGGGGGGDDVHGDIHSDGNNDGGDNNSLTKHVSHQYTRHLHNSTPSLRATHDSSSDSNLCPVCATNLLKLYIADIHSHAQDKTYLQKISNEDYEKFKEFHINQCLTNFDFDTNHSNRFSPDNSKTLKNKMLVYNIPPIPKPMYENIESGSNSLPIEKANKSEEIKGDAYDEEDDDDEEEEEEDNECVICLESLNPGDKVGRLECLCVFHYKCIKDWFNKKGYGECPVHFLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN11</accession>
    <name>C4YN11_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN11"/>
    <dbReference type="PaxDb" id="5476-C4YN11"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02249"/>
    <dbReference type="HOGENOM" id="CLU_112097_0_0_1"/>
    <dbReference type="OMA" id="WINFIFT"/>
    <dbReference type="OrthoDB" id="4008673at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024316">
        <property type="entry name" value="APQ12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12716">
        <property type="entry name" value="Apq12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="214" mass="25084" checksum="4B2AA799D5DF5494" modified="2010-10-05" version="1">MEVKDIFVQIGTIIVFLLEFFFRNSITLIVHAHKNYPDITNVIFFILGVYIIYKILVRTLRSWFNFMIFTIKLIFVLFFVFLVFVIYLRGWETFIYQDVPFLKKSFGHLKAFNDSTTKNGGFGFSNILNFATQFNLNDIKSIFTNVEKNIKENLDESSEYFEYINSQFGNGNGNEPDYDNIQKLVEEGIGYLQENVDLNALRNNIQDILNGHQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNM1</accession>
    <name>C4YNM1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_01484</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNM1"/>
    <dbReference type="PaxDb" id="5476-C4YNM1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01484"/>
    <dbReference type="HOGENOM" id="CLU_003182_0_2_1"/>
    <dbReference type="OMA" id="GMIMFPI"/>
    <dbReference type="OrthoDB" id="409725at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000012">
        <property type="entry name" value="Sulfate transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052706">
        <property type="entry name" value="Membrane-Transporter-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310:SF4">
        <property type="entry name" value="AFR304WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310">
        <property type="entry name" value="SULFATE TRANSPORTER YBAR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="524"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="577"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="10">
        <location>
            <begin position="645"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="59"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="121"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ43254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="998" mass="110423" checksum="2C985B5BB78738CF" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-02-22" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNP4</accession>
    <name>THI4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamine thiazole synthase</fullName>
            <ecNumber evidence="1">2.4.2.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Thiazole biosynthetic enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">THI4</name>
        <name type="ORF">CAWG_02825</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) = [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + nicotinamide + 3 H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:55708"/>
            <dbReference type="Rhea" id="RHEA-COMP:14264"/>
            <dbReference type="Rhea" id="RHEA-COMP:14265"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:90873"/>
            <dbReference type="ChEBI" id="CHEBI:139151"/>
            <dbReference type="EC" id="2.4.2.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="1">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homooctamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">During the catalytic reaction, a sulfide is transferred from Cys-210 to a reaction intermediate, generating a dehydroalanine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the THI4 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.60" evidence="1"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNP4"/>
    <dbReference type="SMR" id="C4YNP4"/>
    <dbReference type="PaxDb" id="5476-C4YNP4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02825"/>
    <dbReference type="HOGENOM" id="CLU_053727_0_0_1"/>
    <dbReference type="OMA" id="MFPRIVV"/>
    <dbReference type="OrthoDB" id="410463at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160205">
        <property type="term" value="F:cysteine-dependent adenosine diphosphate thiazole synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052837">
        <property type="term" value="P:thiazole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03158">
        <property type="entry name" value="THI4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027495">
        <property type="entry name" value="Sti35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002922">
        <property type="entry name" value="Thi4_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00292">
        <property type="entry name" value="sulfide-dependent adenosine diphosphate thiazole synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43422">
        <property type="entry name" value="THIAMINE THIAZOLE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43422:SF3">
        <property type="entry name" value="THIAMINE THIAZOLE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01946">
        <property type="entry name" value="Thi4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000415872" description="Thiamine thiazole synthase">
        <location>
            <begin position="1"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="104"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="315"/>
            <end position="317"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="2,3-didehydroalanine (Cys)" evidence="1">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03158"/>
        </source>
    </evidence>
    <sequence length="354" mass="38269" checksum="58288EFF2229B9BD" modified="2009-07-28" version="1">MTPPTMLQTAPVESFNLNPKSTQQAINLKSDAKNGKVSFADWNEFKFAPIRESTVSRAMTRRYFADLDKFAESDIVIIGAGSAGLSAAYTLGKNRPDLKIAIIEASVSPGGGCWLGGQLFSAMVLRKPAHLFLDDMGLDYEDEGDYVVVKHAALFMSTLMSKVLQFPNIKLFNATAVEDLITRKDPATNLQRIAGVVVNWAQLDHDTQSCMDPNTINCNVVLSTSGHDGPFGAFTAKRLEQLGRAPRDVTAGFTKPSITTSKLQEPEPISNFQLGGMKGLDMNKAEDAIVKGTREVVPGLVIAGMELAEVDGSNRMRPTFGAMALSGVKAAESVLNVLELRKQQNEACYGAYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNQ3</accession>
    <name>C4YNQ3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Dynein heavy chain, cytosolic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_02835</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YNQ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02835"/>
    <dbReference type="HOGENOM" id="CLU_000038_8_1_1"/>
    <dbReference type="OMA" id="YSIMAVH"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF36">
        <property type="entry name" value="DYNEIN HEAVY CHAIN, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Dynein heavy chain tail" evidence="12">
        <location>
            <begin position="202"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain linker" evidence="13">
        <location>
            <begin position="1252"/>
            <end position="1560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ44562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1560" mass="182233" checksum="99FC95A7EAC19FFA" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNU8</accession>
    <name>C4YNU8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycine zipper 2TM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNU8"/>
    <dbReference type="PaxDb" id="5476-C4YNU8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02881"/>
    <dbReference type="HOGENOM" id="CLU_099131_0_0_1"/>
    <dbReference type="OMA" id="YGRNDNY"/>
    <dbReference type="OrthoDB" id="4070509at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008816">
        <property type="entry name" value="Gly_zipper_2TM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014">
        <property type="entry name" value="EXPRESSION LETHALITY PROTEIN HEL10, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014:SF10">
        <property type="entry name" value="RICH PROTEIN MS8, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05433">
        <property type="entry name" value="Rick_17kDa_Anti"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycine zipper 2TM" evidence="2">
        <location>
            <begin position="39"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="191" mass="20544" checksum="9AB7028C8F3535FF" modified="2009-07-28" version="1">MSANDFYSSGDQSNYDPKRSSNQGSSSSNDEQQDRGLLSTVAGGVAGGYGGHKLGEKAQHGTLGTVLGAIGGAIGANKLEDAYEDRKEHKKHEQQYGGSGKHEGGRHEGGFGGGRPNDRYEGDRRNDNYGGGYNDRRDDGYGGGYGGGRPDDRRHEGGFGGGRPDDRFGGGRPDDRFGGDRRDDRRDDRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP81</accession>
    <name>C4YP81_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_03027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YP81"/>
    <dbReference type="PaxDb" id="5476-C4YP81"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03027"/>
    <dbReference type="HOGENOM" id="CLU_034207_0_0_1"/>
    <dbReference type="OMA" id="NDEFNIW"/>
    <dbReference type="OrthoDB" id="4023759at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF7">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ44740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="367" mass="42543" checksum="B48B0E36E2677845" modified="2010-10-05" version="1">MTEYSSPVEKDHLHRELILTQPTTILGISKFELKLLKFYDYQCISMFSYGHNQEIHNTWKYKVPHLFIQSQLVRNSIFALASMVLQSTITPAFNDSLQIAQIQNNLFNSTLEYFLDVLNQTKSIINGCPETIDFQNVTTAKELTVSSTILFTILAINPNRLLPLISFDKSQSDFISISKGVVMIIAKASPIVFGSDLIGIIYYGTLNGVNPPNLNNPTFPIIKNLINDLNNNNNNIYDYSSSTYELLYESLDILNKGMYATQSFEFPVPFFRWINLISDDFRQLLYDQDEFALRLLFVFSSLCLYAGFSLNDEFNIWKDFIDWYKHDQEGKYNGQFKYLMDGKLYQLIIVEKKRCNKFKEFPELDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP87</accession>
    <name>C4YP87_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ecm29p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_03034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YP87"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03034"/>
    <dbReference type="HOGENOM" id="CLU_000880_1_0_1"/>
    <dbReference type="OMA" id="CRIKDIE"/>
    <dbReference type="OrthoDB" id="16066at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024372">
        <property type="entry name" value="Ecm29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055443">
        <property type="entry name" value="HEAT_ECM29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF19">
        <property type="entry name" value="PROTEASOME ADAPTER AND SCAFFOLD PROTEIN ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23731">
        <property type="entry name" value="ARM_ECM29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13001">
        <property type="entry name" value="ECM29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24492">
        <property type="entry name" value="HEAT_ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome component Ecm29 N-terminal" evidence="5">
        <location>
            <begin position="54"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome adapter and scaffold protein ECM29 HEAT-repeat" evidence="6">
        <location>
            <begin position="1248"/>
            <end position="1409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ44746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1797" mass="201811" checksum="13908D92472513A8" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPM4</accession>
    <name>C4YPM4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">2-oxoglutarate dehydrogenase complex component E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_02425</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:20092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="5"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPM4"/>
    <dbReference type="SMR" id="C4YPM4"/>
    <dbReference type="PaxDb" id="5476-C4YPM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02425"/>
    <dbReference type="HOGENOM" id="CLU_004709_1_0_1"/>
    <dbReference type="OMA" id="RDSYCRT"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1150:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12470:FF:000003">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="17">
        <location>
            <begin position="633"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ44163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="996" mass="112040" checksum="383107A1F3DA9D93" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPQ7</accession>
    <name>C4YPQ7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="17">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAWG_02458</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="16">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="17"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPQ7"/>
    <dbReference type="PaxDb" id="5476-C4YPQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02458"/>
    <dbReference type="HOGENOM" id="CLU_002360_9_2_1"/>
    <dbReference type="OMA" id="YRMYVKG"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000131">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="933"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="960"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1003"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1099"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1132"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="109"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="723"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1185"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="723"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEQ44196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1211" mass="133768" checksum="B0D91F73A75BA4C0" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPS4</accession>
    <name>C4YPS4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_02476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
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            <taxon>Debaryomycetaceae</taxon>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
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            <position position="1"/>
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    </feature>
    <evidence type="ECO:0000313" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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                <person name="Forche A."/>
                <person name="Reedy J.L."/>
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                <person name="Brunke S."/>
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                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
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                <person name="Berriman M."/>
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                <person name="Lorenz M.C."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="C:preribosome, large subunit precursor"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:ribosomal large subunit biogenesis"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ44267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
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    </evidence>
    <sequence length="206" mass="23806" checksum="ECF4071AACD89273" modified="2009-07-28" version="1">MAPRQSKTAKRNKTQNKTRTVDSEVFSDSAAKNLLADQPKLTPKSKVKKISKLALKKQQAKIRLYGAKNGKEYREDQLNIPTLNKAIVPGVKAKRGKKGKKFVDDNDTLTMNRLVKSINDKYDQVNESKLEKSRRLEEIRDLKRQEIERKEQQKKDKLEGKKDELRSKASVARSTRRKNAKARRADEESQEQEEESPKKKKKVSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQB3</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name type="scientific">Candida albicans (strain WO-1)</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
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                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
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                <person name="Lorenz M.C."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
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    </reference>
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        <property type="component" value="Chromosome 3"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="118" mass="14109" checksum="2555E47A0E973851" modified="2009-07-28" version="1">MCVKQTIKNKYRNKENERRNLFIVFFSRSFLLRIKLVLMSLYHFRWIFPFGFFLLLLLLLLYSGLLSHVIGIFKSFSFIVFLFFSPLVPFDIANSTQLLQYSFGYNEKKKTPRSLTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQF0</accession>
    <name>C4YQF0_CANAW</name>
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        <recommendedName>
            <fullName evidence="8">Cell division control protein 25</fullName>
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    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_02707</name>
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    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pichiomycetes</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
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                <person name="Brunke S."/>
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                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
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                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
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                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQF0"/>
    <dbReference type="PaxDb" id="5476-C4YQF0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02707"/>
    <dbReference type="HOGENOM" id="CLU_002632_2_0_1"/>
    <dbReference type="OMA" id="IAKECCE"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="164"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="332"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ44439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="595" mass="68650" checksum="F9EF2B9DDB6C16A7" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQL4</accession>
    <name>C4YQL4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_02773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQL4"/>
    <dbReference type="PaxDb" id="5476-C4YQL4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02773"/>
    <dbReference type="HOGENOM" id="CLU_180181_0_0_1"/>
    <dbReference type="OMA" id="ITFNTME"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ44503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="72" mass="8689" checksum="532DB05E2F3767F4" modified="2009-07-28" version="1">MSQTLTFASLYTIIRLIERSYQLDTKQKKKRKKQRTLTTLIIITFNTMELNTYLSSRITLFNKQKKNKNNTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRG9</accession>
    <name>C4YRG9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_04668</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRG9"/>
    <dbReference type="PaxDb" id="5476-C4YRG9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04668"/>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="OMA" id="AWYAMSK"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ46322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="341" mass="37607" checksum="A1F19028C1900A2F" modified="2009-07-28" version="1">MSSSTTVFVSGASGFIAQTLVKQLIEKGYKVVGTVRSNEKGDSLKESLKAAKLQSENFTYEIVKDIAVKGAFDDALKKHPEVTVFLHTASPFHFNVTDIEKELLTPAVEGTNNALQAIKTHGPQIKRVVVTSSYAAVGRFADLADPSIPATEESWNPITWEQSLSNPLAGYVGSKKFAEKAAWDFVEKEKPNFTLSVINPVYVFGPQAFEIKNKSQLNTSSEIINGLLNSKPDSKFDNLTGYFIDVRDVAKAHIVAFEKDSIQGQRLILAESPFSTQSILDLIRKDFPQLDSQLPKGDPSQADAWKKAESKIENEKTRELLGFKFIDFKKSIDDSVAQIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRL9</accession>
    <name>C4YRL9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein FMP42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_04720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC43A transporter (TC 2.A.1.44) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRL9"/>
    <dbReference type="PaxDb" id="5476-C4YRL9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04720"/>
    <dbReference type="HOGENOM" id="CLU_014401_1_1_1"/>
    <dbReference type="OMA" id="IQMLRLN"/>
    <dbReference type="OrthoDB" id="330047at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF2">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ46372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="54877" checksum="60F34B28CCE50374" modified="2009-07-28" version="1">MLPSEVSYSKRLIQCTCAIFWCLLSGGPIFGFAALKPILIKEHVYEYLCDVHTPIFTSFNSNNDNNDIIAKCTEQDLKLNMMFTVAAMLTNVSALAIGRILDVYGPKVCGLIGAFFLYLACFVFIYSKYLAGSIIDPYLLGYSFLALGGPFAFISSFQLSNSFPKSSGTILALITGAFDASSAVFLLYRIGYNASLGSFTLEKFFTLYLSVPTFIAVVQIFIMNSDSYQTEGTSKLCVNDEENHGHVASPVSSNDQETTPLLSEPATRTRRDSMGDAIKHPYEIEGEEFLVEHSSGVFGVMHGYSAQEQIKSWWFVLTTLLSIIMMLRLNYFMATIGTQYQYIFGSFELADQINKFFDVALPLGGLISVPFIGLFLDNCSTLMVLVIMMLLSLTIGLLGLVSNYALAVLGICMFVAYRPLFYTVVSDFCAKVFGFQTFGTVYGAVMCLSGIFNFGQSFLDELTHTTFNMNPIPINVILLVLTGIIGGSTVGYVYKATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRQ4</accession>
    <name>C4YRQ4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04757</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mS38 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRQ4"/>
    <dbReference type="SMR" id="C4YRQ4"/>
    <dbReference type="PaxDb" id="5476-C4YRQ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04757"/>
    <dbReference type="HOGENOM" id="CLU_2049399_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="Ribosomal_mS38_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035">
        <property type="entry name" value="AURORA KINASE A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="COX24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein mS38 C-terminal" evidence="6">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ46407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="130" mass="14921" checksum="E41DE1C66DF3C627" modified="2010-10-05" version="1">MFRSILRFPSKISTGVSVFKQFASTTTTTTTINTVFARPSILASTSTTFNSSSPSLVSFFPYNRPTSTPVEFQPLSIEPKEYDLDTVDKDDDNNTMHALSVLRKRRLKMKKHKYKKRRKAQRALRKRLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRV7</accession>
    <name>C4YRV7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid scramblase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phospholipid scramblase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRV7"/>
    <dbReference type="PaxDb" id="5476-C4YRV7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04814"/>
    <dbReference type="HOGENOM" id="CLU_023808_0_1_1"/>
    <dbReference type="OMA" id="QNWHLWR"/>
    <dbReference type="OrthoDB" id="191150at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005552">
        <property type="entry name" value="Scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248:SF9">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03803">
        <property type="entry name" value="Scramblase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="345" mass="39906" checksum="B8A3FD69E6FEF0EF" modified="2009-07-28" version="1">MFNIKGYRNIASKALVRRNLHTTTLLQSPRFVNSNFNSRTRVTKEISPEEVRQFQEAQARAREQGQAPRNPYSHQFSNDPYYSFHLPDNTNGIITPHDPIYDILKEPTLVIERQIEFMNLFIGFEQANRYIIMNASGERIGYMEEKDVGFGKMLGRQFFRLHRPFDIDVFNARGELAMSIKRPFSWINSHIKALLPGYDYNNEIMYEVVGESVQSWHLWRRKYNLFKLEDETTDEYEQFGAVDAPFLSFDFPVKNAAGEVVASIDRNWVGLGREMFTDTGVYILRYDPKSFEGMEAAYGTISKQGITLDQRAVILSCFTSIDFDYFSRHSGGHGLFSFGGSYDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS99</accession>
    <name>C4YS99_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aminopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_04960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS99"/>
    <dbReference type="PaxDb" id="5476-C4YS99"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04960"/>
    <dbReference type="HOGENOM" id="CLU_003705_3_0_1"/>
    <dbReference type="OMA" id="DMAMENF"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000063">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF299">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="5">
        <location>
            <begin position="69"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="3">
        <location>
            <begin position="274"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="4">
        <location>
            <begin position="603"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ46602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="996" mass="115099" checksum="2F746B7BE4315EC7" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSB0</accession>
    <name>C4YSB0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_04972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSB0"/>
    <dbReference type="PaxDb" id="5476-C4YSB0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04972"/>
    <dbReference type="HOGENOM" id="CLU_048592_0_0_1"/>
    <dbReference type="OMA" id="FFIRFIN"/>
    <dbReference type="OrthoDB" id="4025093at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="450" mass="53043" checksum="BD1826B1BD3B2175" modified="2009-07-28" version="1">MSPSDLLIELSEFINADNHQMKLKNILVSKFILKFPIEIIYKILSYVPDLYLLVFFSINLKIINCKSKCGKISIKDLESYIFNNSNDSLIDKTKMGGKIIYLDLKPLIDINSINYQTLEDLLIFKKIDFRFLNKFQFYIHSLNVKHWQFPLFMSPFFIRFINKEKTKVEIDDWNRRIMDGLDLDSTMISAAAAATTTTTPTTPITNNNYNSRVRGHHHMISKPITTPIITTTTTITTSSSNSTISPFTVDVKHFSYIIQNLKNKIPGFNQWQINQQKNFFNNIKNTNFQFTLKGVDENCWFKNFNFTKLNLKTYYLYQDNYKLINLFNFNNLIKLTIDFGQSPLNFIPHWCQFLQNLNNLEIFNLNIGKICLIDICLIILKLNRLIEFNLKTFKCWTQTFWKWLILKLIKQKYHGHHCSSHKSNQHKPKNHCSSPDKTKEFKFTMQFIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSD4</accession>
    <name>C4YSD4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="10">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_04997</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="10"/>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSD4"/>
    <dbReference type="SMR" id="C4YSD4"/>
    <dbReference type="PaxDb" id="5476-C4YSD4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04997"/>
    <dbReference type="HOGENOM" id="CLU_022477_0_1_1"/>
    <dbReference type="OMA" id="CQFANVQ"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF28">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6 10" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="12">
        <location>
            <begin position="18"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ46637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="470" mass="52038" checksum="8FC84DF98EBD12D0" modified="2010-10-05" version="1">MSAYALSQSHRQLTEGHLKDTDPEVDQIIKDEIDRQQHSIVLIASENFTTTAVFDALGTPMCNKYSEGYPGARYYGGNEHIDRMELLCQERALKAFGLTPDKWGVNVQTLSGSPANLQVYQAIMKPHERLMGLDLPHGGHLSHGYQTDSRKISAVSTYFETMPYRVDLETGLIDYDMLEKTAVLYRPKVLVAGTSAYCRLIDYKRMREIADKVGAYLVVDMAHISGLIAAGVIPSPFEYADIVTTTTHKSLRGPRGAMIFFRRGVRSVNPKTGQEILYDLENPINFSVFPGHQGGPHNHTIAALATALKQANTPEFKEYQEQVLKNAKALESEFTKKGYKLVSDGTDSHMVLVSLKDKQIDGARVETVCEKINIALNKNSIPGDKSALVPGGVRIGAPAMTTRGLGEEDFKKIVSYIDFAVNYAKEVQSQLPKDANKLKDFKNAVSGDSEKLKAVRDEIYQWAGSFPLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSJ1</accession>
    <name>C4YSJ1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_05057</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYBBP1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSJ1"/>
    <dbReference type="PaxDb" id="5476-C4YSJ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05057"/>
    <dbReference type="HOGENOM" id="CLU_005212_1_0_1"/>
    <dbReference type="OMA" id="VWKHDDP"/>
    <dbReference type="OrthoDB" id="342531at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007015">
        <property type="entry name" value="DNA_pol_V/MYBBP1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213:SF2">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04931">
        <property type="entry name" value="DNA_pol_phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="726"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="733"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ46694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1057" mass="121773" checksum="1A3F61FF1FF18A61" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSK4</accession>
    <name>C4YSK4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Ribosome assembly factor mrt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_05072</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Associates with the pre-60S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSK4"/>
    <dbReference type="SMR" id="C4YSK4"/>
    <dbReference type="PaxDb" id="5476-C4YSK4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05072"/>
    <dbReference type="HOGENOM" id="CLU_071690_0_0_1"/>
    <dbReference type="OMA" id="LEWAENY"/>
    <dbReference type="OrthoDB" id="10262308at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05796">
        <property type="entry name" value="Ribosomal_P0_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000005">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000003">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033867">
        <property type="entry name" value="Mrt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="8">
        <location>
            <begin position="129"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ46707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="230" mass="26230" checksum="A9F5CA9E2DDEC9DB" modified="2010-10-05" version="1">MPRSKRSKLVTLAQTEKKGKENKTRLFDEVRSALDTFKYIWVLQFDDIRTPVLQDVRNDWVGSKLILGKRKVLQKALGETIEEEYKDNLHQLSKLCEGLPGLLFTDESPETVEAYFKAYSKQDYSRAKSRAPIDFTIPAGIVYSRGGQISIEEDVPMSHSLEETLRNKLKVPTKIKAGKIILEEPYVVCNKGDVLDTRQALLLKQFGVAASEFKIPILGYYDGEVHKYDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSU6</accession>
    <name>C4YSU6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxin 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSU6"/>
    <dbReference type="PaxDb" id="5476-C4YSU6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05165"/>
    <dbReference type="HOGENOM" id="CLU_665674_0_0_1"/>
    <dbReference type="OMA" id="DHHWDEM"/>
    <dbReference type="OrthoDB" id="5407351at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.230">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="51718" checksum="404E013710972520" modified="2009-07-28" version="1">MDSASCGPSTALQNLNKHAQRDNSLQHQRHQHPQHPQQQGASIHQFRQGQQVDSRLNADFKQFNNGNDFANSFMNQMNIKPSMQQHQHQQHQHQQPAWVNDFSNLSIQQQHQHQNQQQNQGTKSDWHQQFMQQQQQQPNTLQHQSNFQQMTPNYAMGSYQMRNTATTMTPMFHNQTEHQQQHKLEEEQRAFEKQFDMIEKQLQNESVTTEENTNQDEAKEEFARIARKAETSMKTIDSHDSEMNEKFQNSQFLKLMSSIGNRQVELEGDKLVTSDSKEDIREKGIPETITATNPTITTAPRDTLEGQFTSQGPSNPDFAREMYDQIPRPKPANTAFPHPSSGDSEHEQQQEPNDPHQNTLPDPLAHIQDGQLSDINDPLTAARIISGGQVQMSDWVEDYDTISDTPSKLETDSNNNPNVRPFRKGQIVDHHWDEMYRDYRHDDDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSV0</accession>
    <name>C4YSV0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS11m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_05169</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSV0"/>
    <dbReference type="PaxDb" id="5476-C4YSV0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05169"/>
    <dbReference type="HOGENOM" id="CLU_072439_4_0_1"/>
    <dbReference type="OMA" id="FHRHNTL"/>
    <dbReference type="OrthoDB" id="1654884at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000011">
        <property type="entry name" value="37S ribosomal protein S18, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ46803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="215" mass="24426" checksum="712F93EC4E41EF10" modified="2009-07-28" version="1">MFSGISKLVLGKSAISSAYSIPKPFNYQTISRALSTSSTVASVQRANKNASMSQLAQKLNKNKTNEKVVYWKLYATFNRHNTRCTLVAVVEDLDFMEKNKDLPYNDKVLYYLQLPHKVKYSVTAGQLGFRKSQRQEYEAGFQVSSKMFKTIEERNYIGPHDKIELILKNFGKGREAFQAALLGKEGSKIKNNIVRVCDATVLKFGGDRPKKLRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT64</accession>
    <name>C4YT64_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_05763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT64"/>
    <dbReference type="PaxDb" id="5476-C4YT64"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05763"/>
    <dbReference type="HOGENOM" id="CLU_202220_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ47200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="66" mass="7522" checksum="B89A6394D4865A30" modified="2009-07-28" version="1">MLSNMDYEDLKLDDKVHATTDNNLDMNNILENDESILDGLNMTLLDNGDHANEEFDVDSFLNQFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTM8</accession>
    <name>C4YTM8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="6">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_05523</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="6"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTM8"/>
    <dbReference type="PaxDb" id="5476-C4YTM8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05523"/>
    <dbReference type="HOGENOM" id="CLU_070631_2_2_1"/>
    <dbReference type="OMA" id="FFPCKEC"/>
    <dbReference type="OrthoDB" id="59470at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000002">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF1">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ERV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="7">
        <location>
            <begin position="116"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ46969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="254" mass="29236" checksum="DBF792477AE12F38" modified="2009-07-28" version="1">MIFIRRSLFSALTLVGIIGVIYFMSSSSNTIETSINNISSLTKDDLLSKFNQQPQHQQQQQQQQLSQPALNKPLEEIDTDESVEQEPPKKQQPKVVDVLENKEKFTEIPFMPKMTNETLKAQLGNASWKLFHTILARYPDEPSDQERNTLENYIHLFAQVYPCGDCARHFTKLLAKHPPQTKNRKTAALWGCYVHNIVNEKLNKPEYDCTTILEDYDCGCGDDEKEKDYTLKGESMDHLRQIKIDSKKDKQRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTV8</accession>
    <name>C4YTV8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_05604</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.67" evidence="1"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTV8"/>
    <dbReference type="PaxDb" id="5476-C4YTV8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05604"/>
    <dbReference type="HOGENOM" id="CLU_020105_4_1_1"/>
    <dbReference type="OMA" id="YIESWYR"/>
    <dbReference type="OrthoDB" id="16692at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14497">
        <property type="entry name" value="PTP_PTEN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF81">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="4">
        <location>
            <begin position="19"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="109"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ47049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="396" mass="46302" checksum="155E9C81BEA748D5" modified="2009-07-28" version="1">MLFIKSLIRSIIASPKNQYYDSSTNLKLDLSYITPQLIVTSAPVTNYIESWYRYPLNDLLQFLNSNYGSNWHIFNFRGESPGYDDSLVYRKVSHYPFPDHYPPTMNIIINCIDEIDNLLQVFGDKTNVVAVLHCKAGKGRSGTLCCAYLIYQKYHQSHQSHSNKSFTLEDILLIYTTKRMNYLIGGEGISIISQKRYLQYWYDYIHNKQLRESYINWLNIMKFINLKIIRIGGLKLSNIDYLNISISTYITKIETDTNGNSNNRSNTIVKELIQLTNENCDIDNHDDGHDDYWITYNIHDLKIFQLEDIMIGIQSWSYIWFNIFFESFKSNGHSHGHGHSHGHHNNNKVLFNWDDDIDGFKGFKQKGIKLFNEIELQWDVIITNTNTTKSTDLYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTY1</accession>
    <name>C4YTY1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Lipase</fullName>
            <ecNumber evidence="12">3.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_05629</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:12045"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the AB hydrolase superfamily. Lipase family. Class Lip subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="12"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTY1"/>
    <dbReference type="ESTHER" id="canal-LIP5">
        <property type="family name" value="Fungal-Bact_LIP"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YTY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05629"/>
    <dbReference type="HOGENOM" id="CLU_029538_5_0_1"/>
    <dbReference type="OMA" id="VMGQHGV"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.130:FF:000001">
        <property type="entry name" value="Lipase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR029171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ47072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="463" mass="49947" checksum="5C9C15CADCB01AB6" modified="2009-07-28" version="1">MLYLILFLIAPIYAGLIFPTKPSSDPFYNPPKGFENAAVGDILQSRATPKSITGGFTPLKIQNSWQLLVRSEDSFGNPNVIVTTVIEPVNADPSKIASYQVFEDAAKADCAPSYALQFGSDLTTFVTQAEMYLMAPLLDQGYYVVSPDCEGPKSTFTIGKQSGQAVLNSIRAALKSGKITNIKDDAKVVMWGYSGGSLASGWAAALQPSYAPELGGNLLGAALGGFVTNITATAQATDGTVFAGIVANALGGVANEYSEFKQVLQNDTDQQSIFAEFDSHCLIDGVLNYIGTSFLTGDHKIFKTGWDILKNPKIGKVVEDNGLVYQKQLVPKIPVFIYHGSIDQIVPIVDTKKTYQNWCDAGISSLEFAEDASNGHLTEAIMGAPAALTWIIDRFDGKQTVSGCQHIQRFSNLEYPNIPSSIANYFKAAMDVVLHLGLGPDVQKDQVSPEGIKKLGSIEMRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCT4</accession>
    <name>C4YCT4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Ubiquitin-related modifier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">URM1</name>
        <name evidence="7" type="ORF">CAWG_00318</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the URM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCT4"/>
    <dbReference type="SMR" id="C4YCT4"/>
    <dbReference type="PaxDb" id="5476-C4YCT4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00318"/>
    <dbReference type="HOGENOM" id="CLU_148208_0_0_1"/>
    <dbReference type="OMA" id="IHFMAEK"/>
    <dbReference type="OrthoDB" id="10248987at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01764">
        <property type="entry name" value="Ubl_Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03048">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015221">
        <property type="entry name" value="Urm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14986">
        <property type="entry name" value="RURM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09138">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037379">
        <property type="entry name" value="Ubiquitin-related_modifier_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="modified residue" description="1-thioglycine" evidence="5">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)" evidence="5">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ42120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="101" mass="11171" checksum="14E69AC8D4CD1466" modified="2009-07-28" version="1">MAIKIKVEFLGGLDIISNSVREHKCVIPFEEGEATVADLITYITKNIISDPKDIPVFIEDGTVRPGILVLINDTDWELEGMEEYVIESGDVFTFTSTLHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCW6</accession>
    <name>C4YCW6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_00350</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BIG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCW6"/>
    <dbReference type="PaxDb" id="5476-C4YCW6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00350"/>
    <dbReference type="HOGENOM" id="CLU_067894_0_0_1"/>
    <dbReference type="OMA" id="PNWNPIR"/>
    <dbReference type="OrthoDB" id="9985059at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037654">
        <property type="entry name" value="Big1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28285">
        <property type="entry name" value="PROTEIN BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28285:SF1">
        <property type="entry name" value="PROTEIN BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946693" description="Protein BIG1" evidence="11">
        <location>
            <begin position="17"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ42152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="322" mass="38125" checksum="B9813FDD67FBB3DC" modified="2009-07-28" version="1">MRLFVLLAYIIPFILCQLTPVLVASHKLVRGLKEEINPSNTLPHNVTSVTNMLKKLITECSSDAYLLINQPGLTYADLTTEKKDNWPFLRNYLYMSSTIVGLPRVENPIDLDFLEQYIISNCDAETINVWHDSEDEVVDYYDIRKRVIRIDLSPLSISNHDDRVKEIFEHDQLIRKILRKLPSPHYTIILTSLEPGIIHPVPRFLMEETPASFEIFDDIINDPFHNREIEKNDRFHKVEPNWNPIRDSNDRYYRNKKKDEIHLFDYELWEKNEKLITTIFVMVLSLFMMKIISFFNYLKQKIIQKKQQKSKRGIIADDKKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD27</accession>
    <name>C4YD27_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_00415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD27"/>
    <dbReference type="PaxDb" id="5476-C4YD27"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00415"/>
    <dbReference type="HOGENOM" id="CLU_363685_0_0_1"/>
    <dbReference type="OMA" id="NMELPTY"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="445"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ42213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="733" mass="82177" checksum="31122ACA23BA8023" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDE4</accession>
    <name>C4YDE4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_00537</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDE4"/>
    <dbReference type="PaxDb" id="5476-C4YDE4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00537"/>
    <dbReference type="HOGENOM" id="CLU_041869_3_1_1"/>
    <dbReference type="OMA" id="HIVFYDA"/>
    <dbReference type="OrthoDB" id="277802at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="32"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ42330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="131" mass="15108" checksum="039A455284B2954B" modified="2009-07-28" version="1">MPSTKRSSSTEYSHKDSKKKVKLDYVNLKPSQTLYVKNLNTKINKKILLHNLYLLFSAFGDIISINLQNGFAFIIFSNLNSATLALRNLKNQDFFDKPLVLNYAVKESKVISQEKQKLQDDNDEEVMPSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDM2</accession>
    <name>C4YDM2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_00619</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the profilin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDM2"/>
    <dbReference type="SMR" id="C4YDM2"/>
    <dbReference type="PaxDb" id="5476-C4YDM2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00619"/>
    <dbReference type="HOGENOM" id="CLU_120772_1_0_1"/>
    <dbReference type="OMA" id="QGQKFML"/>
    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000001">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027310">
        <property type="entry name" value="Profilin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF0">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00392">
        <property type="entry name" value="PROFILIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01640">
        <property type="entry name" value="PROFILINPLNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00414">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ42408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="126" mass="13809" checksum="85AE32306E4A3B7A" modified="2010-10-05" version="1">MSWQAYTDNLIANGKVDKAALYSRAGDALWAQSGSFELQQPEITEIAKGFDSAEGLQTSGLHVQGQKYFLLRADDRSIYGKHEAEGVICVRTKQTILIAHYPSGVQPGEATTLVEKLADYLINVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDM5</accession>
    <name>C4YDM5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nrp1p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_00622</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDM5"/>
    <dbReference type="PaxDb" id="5476-C4YDM5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00622"/>
    <dbReference type="HOGENOM" id="CLU_022834_1_0_1"/>
    <dbReference type="OMA" id="DWKCGEN"/>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000024">
        <property type="entry name" value="RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111:SF40">
        <property type="entry name" value="RNA-BINDING PROTEIN INVOLVED IN HETEROCHROMATIN ASSEMBLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="264"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="8">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="8">
        <location>
            <begin position="540"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="480"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="610"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="678"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="424"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="610"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="626"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="639"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="678"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="689"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="738"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ42411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="763" mass="84768" checksum="7CED5C4CC313AF9D" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDM9</accession>
    <name>C4YDM9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exosome complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_00626</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the C1D family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDM9"/>
    <dbReference type="PaxDb" id="5476-C4YDM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00626"/>
    <dbReference type="HOGENOM" id="CLU_101423_0_0_1"/>
    <dbReference type="OMA" id="FQGTHTK"/>
    <dbReference type="OrthoDB" id="1421013at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011082">
        <property type="entry name" value="Exosome-assoc_fac/DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341:SF3">
        <property type="entry name" value="NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341">
        <property type="entry name" value="SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="162"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="99"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ42415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="237" mass="26531" checksum="D0F873C47774CA87" modified="2009-07-28" version="1">MENIENLKIYINSLSQSISAYESALSPLQNKQLSDMILNINTTSSTTSTTSTSEEQQIQILNNFAYILISTLFSYLKSLGIDTDSHPIKMELSRIKSSMNRLKNIKNEINGDTNKQEEEEEEKEKLKKSKEYLSRTLGVRDVGSSVDVKSMGTSAISKQNFQGKHIKFDDNKDGDEKKDDGNKNDLKKSKNKKSNGTGSSKSNSKSKSKSKSKLNVKESKITKPKSNKKSSTKNKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDN3</accession>
    <name>C4YDN3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDN3"/>
    <dbReference type="PaxDb" id="5476-C4YDN3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00630"/>
    <dbReference type="HOGENOM" id="CLU_1421248_0_0_1"/>
    <dbReference type="OMA" id="GFDFVDY"/>
    <dbReference type="OrthoDB" id="4002850at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944148" evidence="1">
        <location>
            <begin position="20"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="191" mass="21294" checksum="02F6EA35DDAC1D68" modified="2010-10-05" version="1">MVSFKSLITLAIAATSVSSFNLLHDDKGFAILPPTNIVLDHLKEVGKKAVTTHYDVLNTIKEDGEIVHVNLHTHETKCTGKYAKDYDNSMYNKLNKKQLFIRTIEDSSLKQCLNKEFEAETSECGFEFIEYNSASGCSSDATKYSCLLDVMKQQDATKKLKDMDDVPAQVRCYHKLEQATKAEVVGGACAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDV8</accession>
    <name>C4YDV8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_00706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDV8"/>
    <dbReference type="PaxDb" id="5476-C4YDV8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00706"/>
    <dbReference type="HOGENOM" id="CLU_073103_0_0_1"/>
    <dbReference type="OMA" id="HEASHNK"/>
    <dbReference type="OrthoDB" id="4022983at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ42494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="313" mass="36061" checksum="A0C01D01DABBC000" modified="2009-07-28" version="1">MTLENLQVKPAEKKLVICLLPGVQSSIHSLDSDRLSLYIIRHGKIYYQFIKSLVAKHKQTIFIIQYNHNTSSTTETTTSNNNIEDVLNYFQFLYQEINSSQQYRFTSFSTIIMYDTAQYDKYQLTPQFIYIQQLLRYISLKHGMKIVSLRNMVDALTIGNIEQLLLTLDSISPIPILDSKGVEIAVQTNDIDRTESNGHEASHNKSQINLYIPYTWDSWNKIVVQGKSIVLPNTDEIIIRNESRLEELDSNYEKSLSRESKNNVNGGTIVDLLLPQDYLQTRNKNKPKIESLPNSTYSLSDMLREIVQPSVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YE73</accession>
    <name>C4YE73_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YE73"/>
    <dbReference type="PaxDb" id="5476-C4YE73"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00826"/>
    <dbReference type="HOGENOM" id="CLU_091867_0_2_1"/>
    <dbReference type="OMA" id="QAKFKAC"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="17660" checksum="537AEC152ECE5E1E" modified="2009-07-28" version="1">MSAAEPTNIDLNSLPPQQLVEFRKSIDEEITHFTQSLQALSAAQSKLKDCISSINNLEQSKENDLLVPLTSSLYIPGQVVTRNKYLVDIGTGYYVEKSADKAHIGYNNKIKKLDDDAKKLKNILVQKNELLNTVNLILRRKVIEMEQEQEGSSAGVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEB9</accession>
    <name>C4YEB9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="19">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CAWG_00874</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="17">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 19">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Mitochondrion inner membrane</location>
            <topology evidence="1 19">Peripheral membrane protein</topology>
            <orientation evidence="1 19">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="19"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEB9"/>
    <dbReference type="PaxDb" id="5476-C4YEB9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00874"/>
    <dbReference type="HOGENOM" id="CLU_014312_6_1_1"/>
    <dbReference type="OMA" id="PTGIWRM"/>
    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:001062">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000026">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 19" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 17 19" id="KW-0274">FAD</keyword>
    <keyword evidence="6 17 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 19" id="KW-0813">Transport</keyword>
    <keyword evidence="5 19" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="20">
        <location>
            <begin position="53"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="21">
        <location>
            <begin position="503"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="58"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="447"/>
            <end position="448"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="18">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000171-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EEQ42655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="638" mass="70212" checksum="92A3F2278A76F57B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEK8</accession>
    <name>C4YEK8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_00965</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGV family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEK8"/>
    <dbReference type="PaxDb" id="5476-C4YEK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00965"/>
    <dbReference type="HOGENOM" id="CLU_029048_0_0_1"/>
    <dbReference type="OMA" id="GALFIWC"/>
    <dbReference type="OrthoDB" id="10252502at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ42744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="394" mass="45611" checksum="DDE9247E013BEBCF" modified="2009-07-28" version="1">MLWKLLRLFIIIKLIQLAIIYFSPCQFDTSSELIIQNLSSTSSSKSYYNVIITTILNKLIVWDSVYFNDLFINPIQFEHQFVFCPGWIQLIKLLNIKNYYTAQLTSILISNLCHFASVITLYYLTNEMDMKFGLVSGLLMIISPAGVFLTGNYSENLSNLLTLLMFLTYYKSINFNDVKQPSNKSITNILGYIISGIFCAINFTVRANGLLLGVIYVFDLYHFIQNKSSSQIILSIITGSILFMTFLMTNIYHYIKFCPGREWCNNTFPSLFQFAQHHYWNVGFLKYWTPNNIPNFILVLPVLIFNIYSLGYMYQELPKNRKLLPLIVINGLIVVGGTFFWNIQILNRITSFSPLIYWTLAYNLKKPWAKYAIGYCIVWNFVQTGLFAAFLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEV5</accession>
    <name>C4YEV5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division control protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_01063</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEV5"/>
    <dbReference type="PaxDb" id="5476-C4YEV5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01063"/>
    <dbReference type="HOGENOM" id="CLU_017718_8_0_1"/>
    <dbReference type="OMA" id="EASHAEI"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000238">
        <property type="entry name" value="Cell division control 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="7">
        <location>
            <begin position="21"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="295"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="361"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ42841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="397" mass="45818" checksum="0796FAF8F9BC8D76" modified="2009-07-28" version="1">MPEPVGIANLPNQRYKIISKEGATFTIMVAGESGLGKTTFINTLFQTSLKPHQEPSHRHNKFTSPHQTVEIDIVRAILEEKNFEIRLNIIDTPGFGNNVDNHDSWVPIIDFIDDQHESYMKQEQQPSRTAKKDLRVHACLYFIRPTGHSLKPLDIEIMKRLSTRVNLIPVIAKADTLSPQELDIFKTRIREIIEAQDISIYTPPLELDDPASAEHAKQLIESMPFAIIGSEEKVEVGPGQFVRGRKYPWGVVEVENDQHCDFKKLRSLLLRTNMLDLVLSTNELHFETFRSVKLGGDEQENGEENGTEELTNEKGEVIKKPSGSKKPRRLHNPKFKEEEDALKKFFTEQVKAEEHRFRQWETNIINERNRLNQDLEEMQSKLKSLEEQVKRLQIAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF17</accession>
    <name>C4YF17_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_01128</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF17"/>
    <dbReference type="PaxDb" id="5476-C4YF17"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01128"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="OMA" id="NSDMYVC"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF9">
        <property type="entry name" value="DICARBOXYLIC AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="10">
        <location>
            <begin position="62"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ42903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="586" mass="65166" checksum="883FFABE2C5288C1" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFA0</accession>
    <name>C4YFA0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH:ubiquinone oxidoreductase intermediate-associated protein 30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_01214</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CIA30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFA0"/>
    <dbReference type="SMR" id="C4YFA0"/>
    <dbReference type="PaxDb" id="5476-C4YFA0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01214"/>
    <dbReference type="HOGENOM" id="CLU_059028_1_1_1"/>
    <dbReference type="OMA" id="WIKAVAQ"/>
    <dbReference type="OrthoDB" id="42561at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF18">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="5">
        <location>
            <begin position="36"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ42986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="227" mass="25897" checksum="02FEDA3758941328" modified="2010-10-05" version="1">MSMKALGLNATKSIFAKQAELTRPVQSVLNFKREPEKSLDQVLTRSDQELGGYSTVNFDIDPKEHCGHFYGNLSLDLPKDNPQVTRSGYAMFRTKDQNQSWLFGDSFWDWTNYSSLVLRVKGDRRKYLVNIQANTPLVTDLFQHRLFLNHPGQWETVVIPLNDFVMTNWGVIQDGSELNKGEVKSVGIGLLDKHYGPYSLKIDWIKVMTGAEVAKVATKSRMERLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFI0</accession>
    <name>C4YFI0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFI0"/>
    <dbReference type="PaxDb" id="5476-C4YFI0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01298"/>
    <dbReference type="HOGENOM" id="CLU_1266708_0_0_1"/>
    <dbReference type="OMA" id="TCMSIAY"/>
    <dbReference type="OrthoDB" id="10333398at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="219" mass="24407" checksum="B7E578BDAA602FE6" modified="2009-07-28" version="1">MNRTCMSIAYLLDTLPTDQNTPPPPPRNILTEISNMNDNAGVNNSSESSVVTSISNTNQSVTVGSSYNPESDDYVHDREGFKRRIERLDETFVDLTSRENPSEEDTNRNIGKNGSPVKKKNKRDKEILNLLSSPPKQGSSRDSLGSSKLKERNVAKTKKIESQASVEFKEIVQSLIELGSEIDAKGLDTHPDMDKILQSLSAIRMDFLHMLTNKKNLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFI5</accession>
    <name>C4YFI5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_01303</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFI5"/>
    <dbReference type="SMR" id="C4YFI5"/>
    <dbReference type="PaxDb" id="5476-C4YFI5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01303"/>
    <dbReference type="HOGENOM" id="CLU_111660_0_1_1"/>
    <dbReference type="OMA" id="FWKQTTH"/>
    <dbReference type="OrthoDB" id="14535at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20266">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045299">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016488">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B14 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006643">
        <property type="entry name" value="NDUA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="9">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ43066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="121" mass="14674" checksum="1D9133082E9E29E7" modified="2010-10-05" version="1">MTLATQFAETTRYSVSNTELKRRVLHLYRKYIRNANEFADLYELDMPVSNIKTKIRQEFERQRFGNDLSVNNVLLMKGQMEFQELINFWKQQCHVMRYFDEQNSYNVVDKNDFVKNFLRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFN9</accession>
    <name>C4YFN9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-directed RNA polymerases I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_00015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFN9"/>
    <dbReference type="SMR" id="C4YFN9"/>
    <dbReference type="PaxDb" id="5476-C4YFN9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00015"/>
    <dbReference type="HOGENOM" id="CLU_179456_0_0_1"/>
    <dbReference type="OMA" id="MTYICGD"/>
    <dbReference type="OrthoDB" id="5585087at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.30:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039747">
        <property type="entry name" value="RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056:SF2">
        <property type="entry name" value="GEO11084P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="Zn_ribbon_RPAB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ41828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="73" mass="8038" checksum="206C1E5F1B2F0866" modified="2009-07-28" version="1">MASPQREGFSIPSSISHAALGQVQSKSLGVKYNCAQCAASFSLSKSDTIRCKECGHRVIYKARTKRMVQFEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFQ5</accession>
    <name>C4YFQ5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_00031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFQ5"/>
    <dbReference type="PaxDb" id="5476-C4YFQ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00031"/>
    <dbReference type="HOGENOM" id="CLU_008263_0_0_1"/>
    <dbReference type="OMA" id="FVHRFKD"/>
    <dbReference type="OrthoDB" id="498590at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013721">
        <property type="entry name" value="STAG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199:SF0">
        <property type="entry name" value="LD34181P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21581">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08514">
        <property type="entry name" value="STAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCD" evidence="2">
        <location>
            <begin position="301"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="941"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="947"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1059"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ41844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1090" mass="126807" checksum="F24BFA10083A0009" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFS5</accession>
    <name>C4YFS5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rho GDP-dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_00051</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFS5"/>
    <dbReference type="SMR" id="C4YFS5"/>
    <dbReference type="PaxDb" id="5476-C4YFS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00051"/>
    <dbReference type="HOGENOM" id="CLU_1885699_0_0_1"/>
    <dbReference type="OMA" id="IANDWTT"/>
    <dbReference type="OrthoDB" id="1683373at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.30:FF:000009">
        <property type="entry name" value="RHO protein GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ41864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15384" checksum="801E6BF4166A07E5" modified="2010-10-05" version="1">MPVETHSDFQVIKLVVNVKGKEPFDVPVKGADSITVTIPGGVKYHMTMHFQVKNKKYEDLRYIQVAKKAGITIRTRELEIGTYEPSEETVYTKDFPEDETPGSWLARGIYSCNSTYYAGDEELFSNDWNLEIVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFT7</accession>
    <name>C4YFT7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAWG_00063</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="7"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFT7"/>
    <dbReference type="PaxDb" id="5476-C4YFT7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00063"/>
    <dbReference type="HOGENOM" id="CLU_015846_7_2_1"/>
    <dbReference type="OMA" id="QPRANGC"/>
    <dbReference type="OrthoDB" id="65434at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000047">
        <property type="entry name" value="serine palmitoyltransferase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="19">
        <location>
            <begin position="163"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEQ41876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="569" mass="63339" checksum="32E24B0D020E138B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG19</accession>
    <name>C4YG19_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YG19"/>
    <dbReference type="PaxDb" id="5476-C4YG19"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00134"/>
    <dbReference type="HOGENOM" id="CLU_2026385_0_0_1"/>
    <dbReference type="OMA" id="NQCTFRR"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ41943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="122" mass="14103" checksum="05F8608AFE71217E" modified="2009-07-28" version="1">MSQLSRKIKDLGSSFDPFIISTHTFVLKAIKWRHSFLHQGFLSIYRSCFFLCHVVALSNQCTFRRHPHALSPLLLLRFMISKTSGSVKRAMSQLNWGYYFLGYYHSSLILNCGYCFVIAIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGG6</accession>
    <name>C4YGG6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_03142</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGG6"/>
    <dbReference type="SMR" id="C4YGG6"/>
    <dbReference type="PaxDb" id="5476-C4YGG6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03142"/>
    <dbReference type="HOGENOM" id="CLU_000688_2_4_1"/>
    <dbReference type="OMA" id="NKISHEH"/>
    <dbReference type="OrthoDB" id="9443236at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000009">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000076">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="209"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ44848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="430" mass="47729" checksum="CBEA3DC2EC921B04" modified="2009-07-28" version="1">MVTLEDLENNQQQEENVIDQEILNSSTSDIINRTKLLDNDIKVMRSESQRLNHEKTVMLERIKDNQEKINNNKQLPYLVGNVVELLNLDADKEASEQGANIDIDAARAGKSAVIKTSTRQTIFLPMIGLVDPSKLKPNDLIGVNKDSYLVLDTLPSEYDSRVKAMEVDEKPTEDYSDIGGLDKQIEELIEAVVLPMKQADKFKNLGIKPPKGALMYGPPGTGKTLLARACAAQSGATFLKLAAPQLVQMFIGDGAKLVRDAFALAKEKAPTIIFIDELDAIGTKRFDSDKSGDREVQRTMLELLNQLDGFGSDDRVKVLAATNRVDTLDPALLRSGRLDRKIEFPLPSEEARESVLKIHARKLHCDNNSVNWRELARSTDEFNGAQLKAVTVEAGMIALRNGKSIIKHEDFVEAISEVQARKSKSVNFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGJ3</accession>
    <name>C4YGJ3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Pyruvate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_03171</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>pyruvate + H(+) = acetaldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:45484"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGJ3"/>
    <dbReference type="SMR" id="C4YGJ3"/>
    <dbReference type="PaxDb" id="5476-C4YGJ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03171"/>
    <dbReference type="HOGENOM" id="CLU_013748_0_2_1"/>
    <dbReference type="OMA" id="IHGPEQR"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000018">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="15">
        <location>
            <begin position="5"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="13">
        <location>
            <begin position="203"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="14">
        <location>
            <begin position="410"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <label>1</label>
            <note>substrate; ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <label>1</label>
            <note>substrate; ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <label>2</label>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <label>1</label>
            <note>substrate; ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEQ44875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="567" mass="62441" checksum="6F74C44548DA2AF5" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-10-19" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGK0</accession>
    <accession>P28869</accession>
    <accession>P87079</accession>
    <accession>P87080</accession>
    <accession>P87081</accession>
    <accession>P87082</accession>
    <accession>P87083</accession>
    <accession>P87084</accession>
    <accession>P87085</accession>
    <accession>P87086</accession>
    <accession>P87322</accession>
    <name>ERK1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>Extracellular signal-regulated kinase 1</fullName>
            <shortName>ERK1</shortName>
            <ecNumber>2.7.11.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>MAP kinase 1</fullName>
            <shortName>MAPK 1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">CEK1</name>
        <name type="synonym">ERK1</name>
        <name type="ORF">CAWG_03179</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1992" name="Proc. Natl. Acad. Sci. U.S.A." volume="89" first="9410" last="9414">
            <title>Dominant negative selection of heterologous genes: isolation of Candida albicans genes that interfere with Saccharomyces cerevisiae mating factor-induced cell cycle arrest.</title>
            <authorList>
                <person name="Whiteway M."/>
                <person name="Dignard D."/>
                <person name="Thomas D.Y."/>
            </authorList>
            <dbReference type="PubMed" id="1409649"/>
            <dbReference type="DOI" id="10.1073/pnas.89.20.9410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Activated by tyrosine and threonine phosphorylation.</text>
    </comment>
    <comment type="domain">
        <text>The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Dually phosphorylated on Thr-226 and Tyr-228, which activates the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAA34343" version="2"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24"/>
    <dbReference type="EMBL" id="M76585">
        <property type="protein sequence ID" value="AAA34343.2"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A47211">
        <property type="entry name" value="A47211"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGK0"/>
    <dbReference type="SMR" id="C4YGK0"/>
    <dbReference type="PaxDb" id="5476-C4YGK0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03179"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OMA" id="CYFLYQM"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="BRENDA" id="2.7.11.24">
        <property type="organism ID" value="1096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07849">
        <property type="entry name" value="STKc_ERK1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000073">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0498">Mitosis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000413039" description="Extracellular signal-regulated kinase 1">
        <location>
            <begin position="1"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="66"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="TXY">
        <location>
            <begin position="226"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="72"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphothreonine" evidence="1">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine" evidence="1">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAA34343." evidence="4" ref="1">
        <original>S</original>
        <variation>SS</variation>
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="415" mass="47836" checksum="572857CFD5B00B67" modified="2009-07-28" version="1">MNIDQHHQLQQQHQQQMLQQQAQAQAQAQAQAQQQQQAAAAAAAANAAATTSSSPRQVSFNVSDHYQILEIVGEGAYGIVCSAIHKPSQQKVAIKKIEPFERSMLCLRTLRELKLLKHFNHENIISILAIQRPINYESFNEIYLIQELMETDLHRVIRTQNLSDDHIQYFIYQTLRALKAMHSANVLHRDLKPSNLLLNSNCDLKICDFGLARSIASQEDNYGFMTEYVATRWYRAPEIMLTFQEYTTAIDVWSVGCILAEMLSGRPLFPGRDYHNQLWLIMEVLGTPNMEDYYNIKSKRAREYIRSLPFCKKIPFSELFANTNNNTSTSNTGGRTNINPLALDLLEKLLIFNPAKRITVEDALKHPYLQLYHDPNDEPISDKIPEDFFDFDKMKDQLTIEDLKKLLYEEIMKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGT8</accession>
    <name>C4YGT8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">uS12 prolyl 3,4-dihydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_03270</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54160"/>
            <dbReference type="Rhea" id="RHEA-COMP:13817"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
            <dbReference type="ChEBI" id="CHEBI:138052"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[ribosomal protein uS12]-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54156"/>
            <dbReference type="Rhea" id="RHEA-COMP:13816"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGT8"/>
    <dbReference type="PaxDb" id="5476-C4YGT8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03270"/>
    <dbReference type="HOGENOM" id="CLU_017005_0_0_1"/>
    <dbReference type="OMA" id="GWYHIPQ"/>
    <dbReference type="OrthoDB" id="430522at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009896">
        <property type="term" value="P:positive regulation of catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000014">
        <property type="entry name" value="Prolyl 3,4-dihydroxylase TPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.20:FF:000002">
        <property type="entry name" value="Prolyl 3,4-dihydroxylase TPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.20">
        <property type="entry name" value="Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019601">
        <property type="entry name" value="Oxoglutarate/Fe-dep_Oase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043044">
        <property type="entry name" value="TPA1/Ofd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051842">
        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117:SF0">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10637">
        <property type="entry name" value="Ofd1_CTDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="14">
        <location>
            <begin position="144"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="531"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ44970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="617" mass="70852" checksum="71A50F36910EBEF0" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHT8</accession>
    <name>C4YHT8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="4 9">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_03640</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the NMT family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="4 9"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHT8"/>
    <dbReference type="PaxDb" id="5476-C4YHT8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03640"/>
    <dbReference type="HOGENOM" id="CLU_022882_1_0_1"/>
    <dbReference type="OMA" id="GWKRDWH"/>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000042">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000056">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015892">
        <property type="entry name" value="N-myristl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00975">
        <property type="entry name" value="NMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00976">
        <property type="entry name" value="NMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="11">
        <location>
            <begin position="62"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="12">
        <location>
            <begin position="237"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ45320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="451" mass="51853" checksum="7CB2FE5E990592E2" modified="2009-07-28" version="1">MSGDNTGNKSNSAPSKSIEELLKLLAMGQELSPAQQKEMKDYKFWKTQPVPSLSETVTEEGPIDKLKTPEDVSNDPLPLISDFEWSTLDIDDNLQLDELYKLLYDNYVEDIDATFRFKYSHEFFQWALKPPGWRKDWHVGVRVKSTGKLVAFIAATPVTFKLNKSNKVIDSVEINFLCIHKKLRNKRLAPVLIKEITRRVNKQNIWQALYTGGSILPTPLTTCRYQHRPINWSKLHDVGFSHLPPNQTKSSMVASYTLPNNPKLKGLRPMTGKDVSTVLSLLYKYQERFDIVQLFTEEEFKHWMLGHDENSDSNVVKSYVVEDENGVITDYFSYYLLPFTVLDNAQHDELGIAYLFYYASDSFEKPNYKKRLNELITDALITSKKFGVDVFNCLTCQDNTYFLKDCKFGSGDGFLNYYLFNYRTFPMDGGIDKKTKEVVEDQTSGIGVVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI06</accession>
    <name>C4YI06_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_03712</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI06"/>
    <dbReference type="PaxDb" id="5476-C4YI06"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03712"/>
    <dbReference type="HOGENOM" id="CLU_015210_1_0_1"/>
    <dbReference type="OMA" id="TSNSRPM"/>
    <dbReference type="OrthoDB" id="449241at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010014">
        <property type="entry name" value="DHP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00272">
        <property type="entry name" value="DPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00408">
        <property type="entry name" value="Diphthamide_biosynthesis_famil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ45388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="529" mass="59212" checksum="B8D5B15170DE7190" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIB7</accession>
    <name>C4YIB7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_04189</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIB7"/>
    <dbReference type="PaxDb" id="5476-C4YIB7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04189"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="OMA" id="FTWFRYA"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ45852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="38285" checksum="30C6CC45051F4BE1" modified="2009-07-28" version="1">MPSFELDSLPYLNPSVDRRIAFITGGSSGLGFYSVLQLYLHGYTVYIAGRSKSRCLKSIKELKNKAIDIRSEYTSSQLNERFLGDLRFLEIDLSNLNSVISAVENFKKLEDHLHILINNAGAMALPYTLTIDKFEIQLQTNFVSPLVLTTKLLPILQKTADKFPKLPTPRIIYLSSFGHQFALPYFNLSNNLNHYPNFIFTWIRYGMAKVAGIHFMKMLTLRNPKVLFLTVHPGLVMNTNLFSYWTRLPIVGIIFWFAFYLFGYFFGVTSKEGANVVIKCALDENLTVENDNGKYFGPDGKESQPSSIATNMDYAARTWIWTIKELSQRGIDIPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIF7</accession>
    <name>C4YIF7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell division control protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_04230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIF7"/>
    <dbReference type="PaxDb" id="5476-C4YIF7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04230"/>
    <dbReference type="HOGENOM" id="CLU_1069869_0_0_1"/>
    <dbReference type="OMA" id="QDNFQYN"/>
    <dbReference type="OrthoDB" id="5357220at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012535">
        <property type="entry name" value="Cell_div_Cdc14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08045">
        <property type="entry name" value="CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ45892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="32542" checksum="A93266877DD6FB6D" modified="2009-07-28" version="1">MEQELTQIINLLTSNELPTTLTGLKQTHKLLMSLLPSIKQYQNLLMNTNNSALMYNQRHIKQNRDLQQLIQFQILQDNFQYNLLQYLLPIYDKYELTLNDYLLSNQIIQGILLIHPNSKRIFSINHHNMKIILDLLDGCNNTNNNNNNKDSANDNMKLSISLISTLIHILLKNYDNYRIFEDLNGCSILIKHFKLSSFENINDQNNTNTNTNSNNNNNEDEELNNNLNFKIIEFLMLYLSEEIDNNGGGKSIQEKSQFFINDFPEIDSLIENLNQLNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIL5</accession>
    <name>C4YIL5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal 60S subunit protein L31B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_04291</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIL5"/>
    <dbReference type="SMR" id="C4YIL5"/>
    <dbReference type="PaxDb" id="5476-C4YIL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04291"/>
    <dbReference type="HOGENOM" id="CLU_112570_1_1_1"/>
    <dbReference type="OMA" id="EVWKQGI"/>
    <dbReference type="OrthoDB" id="9739313at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020052">
        <property type="entry name" value="Ribosomal_eL31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01144">
        <property type="entry name" value="RIBOSOMAL_L31E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ45950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12967" checksum="0FA67CED11287DF7" modified="2009-07-28" version="1">MALQDVVTREYTINLHKRLHGVNFKKRAPKAVKEIKKFATLHMGTTDVRLDPKLNIAIWKRGVQGVENRMRLRISRKRNDEEDAKEKLFAYVEPVIVPSTKGLQTVVVEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIS8</accession>
    <name>C4YIS8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 ubiquitin-protein ligase E3D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_04355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ46013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIS8"/>
    <dbReference type="PaxDb" id="5476-C4YIS8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04355"/>
    <dbReference type="HOGENOM" id="CLU_029122_0_0_1"/>
    <dbReference type="OMA" id="CKASQAS"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019193">
        <property type="entry name" value="UBQ-conj_enz_E2-bd_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09814">
        <property type="entry name" value="HECT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="39909" checksum="D67A5291479557FF" modified="2009-07-28" version="1">MYFSEYLPRLNSISVALDVQSGFNIDEINRISIAGELLSIELKNNPPIDVHLPCKASQASITGLKLANNTVSFGVKIHEKRLDSTVPFTDQAIEKWSCKDLSQTPKIGRNHKFIFVCKNCNSELIDSSQYDFKDMPSEQWYEMMDFWHCHKPDNHEEHKKEYKGILKPDNKTIIIGSYYLLEKSNRNIVKIQDSITCNKCGQLLGEMFQGTLKIFKWCVELQFESGNAIHKEQYRPGLFIYNIILDKINFSAVRKFKIEVEAQSKFIWIMSLGLNVVIDGKICHNALKVLCADNVSKEESYETLDVPYPEVAKSFLNDIKTINSLMPVSMRSVSIGTDNYLISYLSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIT7</accession>
    <name>C4YIT7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Checkpoint protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_04365</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the HUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ46022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIT7"/>
    <dbReference type="PaxDb" id="5476-C4YIT7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04365"/>
    <dbReference type="HOGENOM" id="CLU_074844_0_0_1"/>
    <dbReference type="OMA" id="EPQVWCK"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044778">
        <property type="term" value="P:meiotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000060">
        <property type="entry name" value="Checkpoint protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016580">
        <property type="entry name" value="HUS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007150">
        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900:SF0">
        <property type="entry name" value="CHECKPOINT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900">
        <property type="entry name" value="MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04005">
        <property type="entry name" value="Hus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011312">
        <property type="entry name" value="Cell_cycle_HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ46022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="319" mass="36062" checksum="86D78794F2B4A1FD" modified="2009-07-28" version="1">MKLKLMTKSSEKLKETLSLISHVRKFVVLKFTPSELSVISINGQAVKSEPQVWCKLPVSELFQSCEIQSVRDNTISMEINIDLLVQTLKNFDKANSEGLNIRLQRTDTSGAKGTSTTTGRTASLALFYSNLNINANVVNHTFRIPVKILRDAQDMLHEPTHSDLGLIMRLPNEFVTMFKRLEKFKKVPSSESVTIRASRRNGGFLGFILEESGKFKVTISWNDKLEVHKPTTTENDSLRETLRNGPSQLGENEEDITSDIDEIEVNVKLKDWQSASKIVGRCRTVILYIGERECSLHCLLDDTDDVEIVYFITGSRITH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIX0</accession>
    <name>C4YIX0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nop domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_04399</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ46055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIX0"/>
    <dbReference type="PaxDb" id="5476-C4YIX0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04399"/>
    <dbReference type="HOGENOM" id="CLU_026337_3_1_1"/>
    <dbReference type="OMA" id="EMRRSAN"/>
    <dbReference type="OrthoDB" id="4771285at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027105">
        <property type="entry name" value="Prp31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019175">
        <property type="entry name" value="Prp31_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09785">
        <property type="entry name" value="Prp31_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="273"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ46055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="572" mass="64398" checksum="5B49096C57E6570C" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ22</accession>
    <name>C4YJ22_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_03834</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ22"/>
    <dbReference type="PaxDb" id="5476-C4YJ22"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03834"/>
    <dbReference type="HOGENOM" id="CLU_012893_1_2_1"/>
    <dbReference type="OMA" id="KISHHHI"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="556"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ45506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="610" mass="67022" checksum="6FE952078FBF42D7" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ49</accession>
    <name>C4YJ49_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TrmE-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_03861</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ49"/>
    <dbReference type="PaxDb" id="5476-C4YJ49"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03861"/>
    <dbReference type="HOGENOM" id="CLU_019624_3_1_1"/>
    <dbReference type="OMA" id="EFHCHGG"/>
    <dbReference type="OrthoDB" id="188276at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14858">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001989">
        <property type="entry name" value="GTPase MSS1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="entry name" value="tRNA modification GTPase MnmE domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00450">
        <property type="entry name" value="mnmE_trmE_thdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003661">
        <property type="entry name" value="PRK05291.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714:SF2">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51709">
        <property type="entry name" value="G_TRME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TrmE-type G" evidence="7">
        <location>
            <begin position="249"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ45533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="499" mass="55557" checksum="F7A5C744D4124067" modified="2009-07-28" version="1">MFRQLLHVGKRSLSTDNPLKPTVFALSTKFGKSAIAVVRISGPQSKYIYHKLTNSTKPPKNRIASVRKLYSPEPHSNKKSVFLDEALTLFLPGPKTYTGEDLLELHLHGGVAIIKSVLQSIKKLHDPNNGVIIRQADRGEFSKQAFYNGRLDLTELEGINDMINAETESQRLASLASSSGQTKIEFMKWRNEIINQMANLTMIIDFGEDHDIEETDRMIRDVKENIAKIESEIKAYLSKVKSSQILLNGIQLALLGPPNAGKSSILNILANKDAAIVSEIAGTTRDILDIPLEIGGYKVVVGDTAGIRSFEEADSIEQEGIKRAKQRSMLADLVIVVLDPMSVEKEPLELKEHLKTLVKANKQMLIVLNKQDLFASRSEEMISNYSRLLDLPKNYFHVVSCSTGSGIDNLQKLLIEKFKDLSQSETSNPIIVSSRVQDILENDILFGFKEFYHWADAEDVLVATDCLRQSVDGIGKITGQSIDLEEILDVVFSSFCIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ82</accession>
    <name>C4YJ82_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_03895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ82"/>
    <dbReference type="PaxDb" id="5476-C4YJ82"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03895"/>
    <dbReference type="HOGENOM" id="CLU_014358_0_0_1"/>
    <dbReference type="OMA" id="WKYIILK"/>
    <dbReference type="OrthoDB" id="5563539at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052292">
        <property type="entry name" value="Glucose_repression_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051:SF1">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="684"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="782"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="859"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="891"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="915"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="957"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="975"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ45566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1005" mass="110047" checksum="BE82007E77D7826B" modified="2009-07-28" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJE0</accession>
    <name>C4YJE0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UV excision repair protein RAD23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_03953</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RAD23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJE0"/>
    <dbReference type="PaxDb" id="5476-C4YJE0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03953"/>
    <dbReference type="HOGENOM" id="CLU_040364_0_0_1"/>
    <dbReference type="OMA" id="VACCVRI"/>
    <dbReference type="OrthoDB" id="419317at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000002">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000003">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.540">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004806">
        <property type="entry name" value="Rad23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015360">
        <property type="entry name" value="XPC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036353">
        <property type="entry name" value="XPC-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00601">
        <property type="entry name" value="rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF0">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09280">
        <property type="entry name" value="XPC-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01839">
        <property type="entry name" value="RAD23PROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101238">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="86"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="307"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="132"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="41"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ45624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="348" mass="36003" checksum="3D9B0BE3F7F175F7" modified="2009-07-28" version="1">MINKTKKTPTPVPETKSTTGTSNVENKSTTESSTQNKAQGSTNESTTTTTTSSAPAPAPAGATTTTSEQQQPQPAASNESTFAVGSEREASIQNIMEMGYERPQVEAALRAAFNNPHRAVEYLLTGIPESLQHPVAPAQPPATGTAPAQQTEGNTSESGQQGEDEEHEGDESTQHENLFEAAAAAAAGAGAGGAGSGAGAGAGSAEGDIGGLGDDQQMQLLRAALQSNPELIQPLLEQLAASNPQIANLIQQDPEAFIRMFLSGAPGSGNDLGFEFEDESGETGAGGAAAAATGEDEQGTIRIQLSEQDNNAINRLCELGFERDIVIQVYLACDKNEEVAADILFRDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJH3</accession>
    <name>C4YJH3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cobalt uptake protein COT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_03988</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJH3"/>
    <dbReference type="PaxDb" id="5476-C4YJH3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03988"/>
    <dbReference type="HOGENOM" id="CLU_993953_0_0_1"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="70"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="198"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ45657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="279" mass="30894" checksum="CEE60FC303BF18D6" modified="2009-07-28" version="1">MKSTPSEVFDYLPDNVVERYSNYQPSFSGQSPLNGTSANSSDANNVVNNNNNTSEHSGTNNNTPQSALQKIKQKSMNMEGVFLHVLGDALGNIGVIITALVIWKTDYSWRFLADPITSLFITLIILNSALPLVRKASRILLQSAPPYIDSNLIVNQIKQLPLIKNIHDFHVWNLNEDILIASLHIELNPNCEVNLPLPLPSNGGDNNNNNTKNGSNGDSSIDEEQDQELELEEAPSQIDRKLFLAAVGQVREVLHIYGINSVTIQPEFSNSKKVCRSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJJ1</accession>
    <name>C4YJJ1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">FACT complex subunit POB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_04006</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a stable heterodimer with SPT16. The SPT16-POB3 dimer weakly associates with multiple molecules of NHP6 to form the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the SSRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJJ1"/>
    <dbReference type="PaxDb" id="5476-C4YJJ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04006"/>
    <dbReference type="HOGENOM" id="CLU_017374_3_0_1"/>
    <dbReference type="OMA" id="QVVTKIF"/>
    <dbReference type="OrthoDB" id="498543at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13230">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13231">
        <property type="entry name" value="PH2_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000001">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000098">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.220">
        <property type="entry name" value="Structure-specific recognition protein (SSRP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035417">
        <property type="entry name" value="SSRP1/POB3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038167">
        <property type="entry name" value="SSRP1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17292">
        <property type="entry name" value="POB3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="14">
        <location>
            <begin position="361"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="467"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ45675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="538" mass="60943" checksum="A177D9F9109F8281" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJL1</accession>
    <name>C4YJL1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zinc-regulated transporter 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_04027</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJL1"/>
    <dbReference type="PaxDb" id="5476-C4YJL1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04027"/>
    <dbReference type="HOGENOM" id="CLU_027089_0_2_1"/>
    <dbReference type="OMA" id="CWVEGII"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000007">
        <property type="term" value="F:low-affinity zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF69">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ45695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="41204" checksum="15AEAEA22DA175DE" modified="2009-07-28" version="1">MNSDSISQVFEYLNKRDECPTDNDYNGNIGTRISSIFVIMVTSAIGTLLPLLSSKYSFIRLPPMVYFICKYFGSGVIVATAFIHLLEPAADSLGNECLTGPITEYPWAFGICLMTLFLLFFFELLAYQGIDRKIAKESQLDNQGPHTHSHFGDASMYVKKDDEEEDLENQNEKQADANPYPSHFAHAQEHQDPDVMGTTVNDQSKEQYYGQLLGVFVLEFGVMFHSVFIGLALAVSGDEFKSLYIVLVFHQMFEGLGLGTRIATTNWARHRYTPWILAICYTLCTPIAIAVGLGVRKSYPPGSRRALITNGVFDSISAGILLYTGIVELMAHEFLYSGEFKGPGGFKNMLLAYFVMCWGAGLMALLGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJW7</accession>
    <name>C4YJW7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="2">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_04138</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="2"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJW7"/>
    <dbReference type="PaxDb" id="5476-C4YJW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04138"/>
    <dbReference type="HOGENOM" id="CLU_003051_2_1_1"/>
    <dbReference type="OMA" id="CFNADSI"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09534">
        <property type="entry name" value="SAM_Ste11_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000334">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000130">
        <property type="entry name" value="Serine/threonine-protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029458">
        <property type="entry name" value="Ras-bd_By2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14847">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01304">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM" evidence="13">
        <location>
            <begin position="17"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="545"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="489"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="574"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ45801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="824" mass="91463" checksum="CCBE02A07EE01156" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK44</accession>
    <name>C4YK44_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_05839</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK44"/>
    <dbReference type="PaxDb" id="5476-C4YK44"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05839"/>
    <dbReference type="HOGENOM" id="CLU_036838_2_0_1"/>
    <dbReference type="OMA" id="WVGVETK"/>
    <dbReference type="OrthoDB" id="432381at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02651">
        <property type="entry name" value="nuc_hydro_IU_UC_XIUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.245.10:FF:000008">
        <property type="entry name" value="Uridine nucleosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF4">
        <property type="entry name" value="URIDINE NUCLEOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="4">
        <location>
            <begin position="8"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ47273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="330" mass="36870" checksum="30C7C1082CB3B91F" modified="2010-10-05" version="1">MTKSPIPIWLDCDPGNDDAFAILLSLFDSRFQLLGISTVHGNAPISMTTHNTLGLLDLLRVYNKVKVYKGAEFPLKVPSKFALEVHGKNGLADIEFSENTINEISQDMDCIEAMKQTIDLNSENINLVCTGTLTNVAKLITKYPDVTSQIKWVSIMGGSFGFGNITPYAEFNLHTDPHAAKLVIQELSNKVILSPLNFTHKVIATSEIRKHMYDDNNEKRSSPIRNVFFRILTFYYKVYAANGFLEGPPIHDPLAVYSLLPFFNSFEQYGYTCAQKNIDIITEGVRMGESVIVEGGNTDKGVYIGEAIDNKKFWDSILLALQNADLQTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKE1</accession>
    <name>C4YKE1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_05943</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKE1"/>
    <dbReference type="PaxDb" id="5476-C4YKE1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05943"/>
    <dbReference type="HOGENOM" id="CLU_029456_0_0_1"/>
    <dbReference type="OMA" id="GVCPFTI"/>
    <dbReference type="OrthoDB" id="4096612at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025928">
        <property type="entry name" value="Flocculin_t3_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13928">
        <property type="entry name" value="Flocculin_t3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944284" evidence="7">
        <location>
            <begin position="22"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="162"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="424"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ47370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="539" mass="54903" checksum="C6839D850C9CDAFA" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKF1</accession>
    <name>C4YKF1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKF1"/>
    <dbReference type="ESTHER" id="canal-q59y97">
        <property type="family name" value="CGI-58_ABHD5_ABHD4"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YKF1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05953"/>
    <dbReference type="HOGENOM" id="CLU_017361_3_1_1"/>
    <dbReference type="OMA" id="FNQYQGS"/>
    <dbReference type="OrthoDB" id="7457040at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF23">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE ICT1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="94"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="466" mass="55054" checksum="2798CB11BAFF56EB" modified="2009-07-28" version="1">MYESNDEESDQIKQDRLRNRQIEYELFRTILPSDIYIYPPSQDYENEFNNNDHVNKEYLITGRLIDVKLDDGNFIHEFYLENNNESTFGNQQQHIVIIHGYMAAMGYFIKNVEDVIKIPGVRLHLIDLPGFGNSSRPKFPKEFILEPNSLPAKINQILQIENWFIDKIENWRIKRNINQFKLIGHSMGAYLSCCYLMKYNLSTSGNENEKLVSDVILVSPMGTESNEFSLINDKRFQFNLHNKIDPFQELHFENENENENENENENQLVPDDDDDNNIIINEEITKIWSKLGKPKFPKNWLLKKLWSSNKSPFEFLQNFGPFYSKILSYWSFQRFKNFENNQNTIDLILKLHNYSYSIFNQFQGSGEIAITKLITPEILAKLPLADRGLIDFLVENNINNMWIYGDNDWMNKNGGEYIYQQIKTKNEKITQFKVVEKAGHHIYLDNPQTFNQIVIDFLKLNQLDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKI1</accession>
    <name>C4YKI1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="16">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MCM7</name>
        <name evidence="19" type="ORF">CAWG_05985</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="16"/>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKI1"/>
    <dbReference type="PaxDb" id="5476-C4YKI1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05985"/>
    <dbReference type="HOGENOM" id="CLU_000995_7_2_1"/>
    <dbReference type="OMA" id="AQHVTYV"/>
    <dbReference type="OrthoDB" id="3207464at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000004">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000288">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 16" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="778"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="820"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="859"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="18">
        <location>
            <begin position="392"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEQ47410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="886" mass="99631" checksum="B359390BC52FBE77" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKT8</accession>
    <name>C4YKT8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone-lysine N-methyltransferase, H3 lysine-36 specific</fullName>
            <ecNumber evidence="3">2.1.1.359</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">SET domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAWG_06096</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60324"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:15536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.359"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.359" evidence="3"/>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKT8"/>
    <dbReference type="PaxDb" id="5476-C4YKT8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06096"/>
    <dbReference type="HOGENOM" id="CLU_008492_1_1_1"/>
    <dbReference type="OMA" id="AQSQPCY"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140955">
        <property type="term" value="F:histone H3K36 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
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        <location>
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        <location>
            <begin position="814"/>
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        <location>
            <begin position="507"/>
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            <begin position="696"/>
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    <evidence type="ECO:0000256" key="15">
        <source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="846" mass="95669" checksum="77A84BDCC8F5F148" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL05</accession>
    <name>C4YL05_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_01519</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
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        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
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        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome R"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005524">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:leucine-tRNA ligase activity"/>
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        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
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        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
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    </dbReference>
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        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
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        <property type="entry name" value="tRNA-synt_1"/>
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    </dbReference>
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        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
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        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="49"/>
            <end position="116"/>
        </location>
    </feature>
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        <location>
            <begin position="200"/>
            <end position="771"/>
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    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="810"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine--tRNA ligase RagD-binding" evidence="13">
        <location>
            <begin position="958"/>
            <end position="1013"/>
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    </feature>
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        <location>
            <begin position="134"/>
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    </feature>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ43286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1097" mass="125411" checksum="0143DAC84E0C36A2" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL08</accession>
    <name>C4YL08_CANAW</name>
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        <recommendedName>
            <fullName evidence="9">Mdm1p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_01522</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
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                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">WO-1</strain>
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        <property type="component" value="Chromosome R"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
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        <location>
            <begin position="96"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="4">
        <location>
            <begin position="354"/>
            <end position="490"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ43289.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1032" mass="120348" checksum="B3ACE7235605598E" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL09</accession>
    <name>C4YL09_CANAW</name>
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        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
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        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01523"/>
    <dbReference type="HOGENOM" id="CLU_091402_0_0_1"/>
    <dbReference type="OMA" id="RWNDQYK"/>
    <dbReference type="OrthoDB" id="2444812at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="44"/>
        </location>
    </feature>
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        <location>
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            <end position="173"/>
        </location>
    </feature>
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        <location>
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            <end position="226"/>
        </location>
    </feature>
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        <location>
            <begin position="63"/>
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        </location>
    </feature>
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        <location>
            <begin position="91"/>
            <end position="160"/>
        </location>
    </feature>
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        <location>
            <begin position="211"/>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ43290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL42</accession>
    <name>C4YL42_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 14">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="3 14">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_01557</name>
    </gene>
    <organism evidence="17 18">
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        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
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                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 14"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL42"/>
    <dbReference type="PaxDb" id="5476-C4YL42"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01557"/>
    <dbReference type="HOGENOM" id="CLU_000995_3_2_1"/>
    <dbReference type="OMA" id="RHQQTDK"/>
    <dbReference type="OrthoDB" id="1744952at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.870:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000009">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000115">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 14" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="16">
        <location>
            <begin position="426"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="746"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="767"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ43323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="880" mass="98567" checksum="FEC1D8C5815C33D8" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLE2</accession>
    <name>C4YLE2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLE2"/>
    <dbReference type="PaxDb" id="5476-C4YLE2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01660"/>
    <dbReference type="HOGENOM" id="CLU_969760_0_0_1"/>
    <dbReference type="OMA" id="PLEFPKL"/>
    <dbReference type="OrthoDB" id="4026747at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="287" mass="31670" checksum="A62A10A843C1DA04" modified="2009-07-28" version="1">MESRKPSLFNQLEPHNEDSDSTDISDISEDEDWEDDPPLSPKSQPLEFPKLDHDVPLPRPPSLLSCLLYNNGNNNNNSNNHTNTLHPSNNIPNGSDNNHVYKPRLLRSFTTPTALPALHTPLVKQESVVGISDINVSISSLTTTSSHLSMKNLLSKSSVNLYSAGSTTTTTTTAAMRPNKRLSQPDQLKPSPSSLTSSILFMSQPPDSATTPPPPILPRITTTDSDLTDKLINNDELSKSLKESLLIDNRLAKIPLPEKVIDAGIFLKRESRLADEDDFDDYHSKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLE4</accession>
    <name>C4YLE4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_01662</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">WO-1</strain>
        </source>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
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            <end position="171"/>
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    </feature>
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    </feature>
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        </location>
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            <end position="453"/>
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    </feature>
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        <location>
            <begin position="469"/>
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        <location>
            <begin position="58"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="496" mass="55403" checksum="E6C2CA7AF9144D74" modified="2009-07-28" version="1">MSNSISEAESRGHKSLEIEEYQIDNRTNDESSEILDPHQLNKVYRKLDLRIIPALWCLYFLTSFGSNCYGLTLTMNRAEGHSLAQQLHLTSKDTSTASALYYVGYIIFDVPMNLIMTKVSPQTWLARIVITVGLVYTCYHVLHNAGGVIAVRFISGVVGAGTWPGLSYYVSLWYPNDRSTRRIGYYFTAAQISAAVAGLVSAGFQKMDGVHGYTGWQWMYLVYGVITMTVGIALLWWLPDRPFIGVKSESNRLVEFYRKFTTPPHPLNEQEKELHRKDLEHRYKLLKWTWKDVVNIITDLRIWPLIIMYFGVVGTGFGLAVFGSTIIATNNPNLTSIQVSLLYAPIWLFDLGGILIITPFADRFKKFRALIFSGACVIIIVGMVVTTFAHGSWNKYGGLLIAGFGLGPTVPICMSWSAEIFQKRYGDVGNAVSAALVSGLGNLGSVTSTYALYSGWPEDKARLYRNSNMMLVLMLGVSIIASGVCQLIKDKVRQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLE8</accession>
    <name>C4YLE8_CANAW</name>
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            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_01666</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="Znf_CCCH"/>
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        <property type="entry name" value="Znf_CCCH_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156:SF1">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="CCCH zinc finger"/>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
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        <location>
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        </location>
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        </location>
    </feature>
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            <end position="234"/>
        </location>
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            <end position="234"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ43429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="234" mass="26973" checksum="E4EDFABE95226B01" modified="2009-07-28" version="1">MCDKGINCKYDHDKEKIRICPLYLLGKCYSKNCLLSHSSNDNNTPQCRYFLDKSCQNPNCKYRHFKPAHYNDPNYEIWTCRPFAIGGFCSRGKKCPFLHLLNCPDFEEDNYCVMGRECPLTHQFTLKTQDSIATKSNKYIRDETVVTEESTPTPVKTIVNSYTVDPKLLFVVDETGNYQFYIDNNGGDKSQFDSNLGSSNEFLIELSSSSEESDLEDSQEEDDEIEENEDYVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLX0</accession>
    <name>C4YLX0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_01842</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLX0"/>
    <dbReference type="PaxDb" id="5476-C4YLX0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01842"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OMA" id="YMSLITD"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="40"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ43601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="574" mass="62989" checksum="3278B98FFBF30C35" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM40</accession>
    <name>C4YM40_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sok1p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_01915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM40"/>
    <dbReference type="PaxDb" id="5476-C4YM40"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01915"/>
    <dbReference type="HOGENOM" id="CLU_016970_1_0_1"/>
    <dbReference type="OMA" id="CAPMRDV"/>
    <dbReference type="OrthoDB" id="276323at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF11">
        <property type="entry name" value="LD23868P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="697"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="769"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="783"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ43671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="810" mass="90753" checksum="67C6D2BAD82C178F" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM57</accession>
    <name>C4YM57_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin-related protein 2/3 complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_01933</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Cytoskeleton</location>
            <location evidence="7">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the WD repeat ARPC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM57"/>
    <dbReference type="PaxDb" id="5476-C4YM57"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01933"/>
    <dbReference type="HOGENOM" id="CLU_034396_1_0_1"/>
    <dbReference type="OMA" id="YVWEPSP"/>
    <dbReference type="OrthoDB" id="406844at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000682">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038093">
        <property type="entry name" value="ARP2/3_su1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="55"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ43688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="384" mass="42297" checksum="C9CF314FCC2A6755" modified="2009-07-28" version="1">MSKVPAIYQLGHLPIKDHVFSPDRSILAITKGNDVEVYQISPSNLSSKPQLIAVLKDHDKTVTSVDISPDGSKILTCSQDRNALVWEYANGEYKPTLVLLRINRAATVCRWSPDGSKFAVGSSDRIIAVCYYEEENDWWVSKHLKKPLKSTITTIDWHPNGVLLACGSTDGHVRVFSGYIKGIDAKPDPSVWGTKLPFQTLCGDYTNETNAWIHGVKFSPDGNALAYVSHDSSVGFVYPQGEGLPSRAIFNVKTDNLPFKSVVWLNNQQVCAGGFTCNLVVFQGDENGWQQAYQVEEQKDLTKEVPHSKLGEGGDDDEEISSHQALNMFKQMDLKGRVSKPSAGGKPAKALNTIHQNTINCIRNFDQGRVSTSGIDGKVVIFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM86</accession>
    <name>C4YM86_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mug135-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_01964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0612 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM86"/>
    <dbReference type="PaxDb" id="5476-C4YM86"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01964"/>
    <dbReference type="HOGENOM" id="CLU_2037751_0_0_1"/>
    <dbReference type="OMA" id="QNDRNIH"/>
    <dbReference type="OrthoDB" id="5297016at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013902">
        <property type="entry name" value="Mug135-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08593">
        <property type="entry name" value="Mug135_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mug135-like C-terminal" evidence="2">
        <location>
            <begin position="23"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ43717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="121" mass="14133" checksum="D00B698B5F152866" modified="2009-07-28" version="1">MFNPLSTTTTTIIPLRKKTALLKNNSQNDRNIHFHLITFPNGISVEEYGLPIIKTLQDIENLPKFEVIRYLQGFDIEYNNNNVLSEIHLRNLLKDRLIIEMNYLNGGVKKTKWSKAKKLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YME0</accession>
    <name>C4YME0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_02019</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ARPC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YME0"/>
    <dbReference type="SMR" id="C4YME0"/>
    <dbReference type="PaxDb" id="5476-C4YME0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02019"/>
    <dbReference type="HOGENOM" id="CLU_101888_2_0_1"/>
    <dbReference type="OMA" id="LWHEKAF"/>
    <dbReference type="OrthoDB" id="429520at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.190:FF:000003">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039096">
        <property type="entry name" value="p16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="158" mass="17692" checksum="46A5CFEFEB666B5B" modified="2010-10-05" version="1">MVSEDWRSIDIDALEPDAHLTKEDLLPTDIPPTTNEQVQQVANQIRSNLSSGQFQQALSLALDNVPYVADSSTKELHSKTVFEVLCSIRNNNNLNDLTGFVKSLSSEQQDVLVKYLYNNMSSPYGQKQGGLLLNWFEKTIEVTGVGSIARYLTDRRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMT1</accession>
    <name>C4YMT1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="SMR" id="C4YMT1"/>
    <dbReference type="PaxDb" id="5476-C4YMT1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02168"/>
    <dbReference type="HOGENOM" id="CLU_758611_0_0_1"/>
    <dbReference type="OMA" id="EMGFINY"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.630">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcription termination and cleavage factor, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CSTF2_hinge"/>
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        <property type="entry name" value="CSTF_C_sf"/>
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    </dbReference>
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        <location>
            <begin position="8"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ43912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="365" mass="40536" checksum="7D391D86ACA23B97" modified="2010-10-05" version="1">MPPPLNSNILYVGNIPYDWDESTVESVVCGSGNIVDVRLGFDHVGKNKGFCFVEYKTVQDAQRALPLLQQVVIYQNGRNKKLRVELSKEGYKAQKIKPDTRTIMQLNRSRLPANVRLPNEMIANIPYVSQVPVLPSSGFRSGNMPFPIPQMPLPPPAPPIVVGGPIQQIPSRLLQASKFLPFAPNFKLETANNINVLLSKIPPPQFIELLSQMKSLSQTDPTMVRNFFQSQPEISLSVAQALLLMGFIDNGVIEESSKSISSTPQVQTVQPGIQSTFYMGGQIGGYNNNMYINNGQNFQPQQQQQAIPGSNWPYLPPHVQQKLVNMPPDQAHLAAQILSLPPDSLQQLPPHERQIVDALRAQYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN19</accession>
    <name>C4YN19_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN19"/>
    <dbReference type="PaxDb" id="5476-C4YN19"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02258"/>
    <dbReference type="HOGENOM" id="CLU_089353_0_0_1"/>
    <dbReference type="OMA" id="HIETYPI"/>
    <dbReference type="OrthoDB" id="376826at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17316">
        <property type="entry name" value="Perilipin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946769" evidence="2">
        <location>
            <begin position="33"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="281" mass="31198" checksum="03AC1D0367883052" modified="2009-07-28" version="1">MASIPELLSFLLLVCFLTVLDILRSLITIMSANNNNNNNHNNNSNALQNPVSPKPTEGNSKQESENTVTNELLTFQHLKHYPLVNSTKSAIELIPLSKSVFSIMGNSFSFVRSYQPMKYIVGRSDTLTNRALDEIDKWLPSLQTVEVQDITTPITKPVNDTVETVQNTITAVNGSVNKNFVDPTKSALGSVKEEFQNHVYDAEGKGIISSQADPMVAPLNHTLEQFVDNHFPNTKKVPTEGHASEISRTFKIVGNLISRGEKEKEKEKESSDKSKPEKTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN65</accession>
    <name>C4YN65_CANAW</name>
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        <recommendedName>
            <fullName evidence="2">Protein BFR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_02305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the AATF family.</text>
    </comment>
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        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="AATF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039223">
        <property type="entry name" value="AATF/Bfr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012617">
        <property type="entry name" value="AATF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565">
        <property type="entry name" value="AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565:SF0">
        <property type="entry name" value="PROTEIN AATF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13339">
        <property type="entry name" value="AATF-Che1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08164">
        <property type="entry name" value="TRAUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="179"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Apoptosis-antagonizing transcription factor C-terminal" evidence="4">
        <location>
            <begin position="396"/>
            <end position="477"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="342"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="488"/>
            <end position="512"/>
        </location>
    </feature>
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            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
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        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
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        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="349"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="488"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ44046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="512" mass="58463" checksum="4C9BC3B87CD3A44A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNC7</accession>
    <name>C4YNC7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP synthase f chain, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_01386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNC7"/>
    <dbReference type="SMR" id="C4YNC7"/>
    <dbReference type="PaxDb" id="5476-C4YNC7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01386"/>
    <dbReference type="HOGENOM" id="CLU_152700_1_0_1"/>
    <dbReference type="OMA" id="TIDYQMH"/>
    <dbReference type="OrthoDB" id="5561579at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019727">
        <property type="entry name" value="ATP_synth_F0_fsu_mt_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10791">
        <property type="entry name" value="F1F0-ATPsyn_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="102" mass="11272" checksum="3BD32583FA2398BE" modified="2009-07-28" version="1">MSFVIRRQLSTLIPPKIASAKNLGSNPNAKRMAEVVKFYNKLPQGPAPAAKKSNNPFARYRAAYFDGDNASGKPLVHLAIAVVIFGYSLEYQHLKHAQHEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNU3</accession>
    <name>C4YNU3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_02876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNU3"/>
    <dbReference type="PaxDb" id="5476-C4YNU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02876"/>
    <dbReference type="HOGENOM" id="CLU_045155_1_0_1"/>
    <dbReference type="OMA" id="REWSEYR"/>
    <dbReference type="OrthoDB" id="10256055at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677">
        <property type="entry name" value="YALI0B19030P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ44602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="42732" checksum="D46DB809C0B193C3" modified="2009-07-28" version="1">MATIDVEQAILDGNTHKSIPLSVYESSLAPTYQSSLSSLSSSIINSFSLKSPIEFDPLIHLTYYANGSRAQKLYDQTRRLTLEQLGLNHKQQQSQQISDIGVSDPFQLFTDEAITIMRQEVLQRDTFMKYARYSYNSTSGMDCVVRGFVKDGDEINCPFTYQAWTHCKTMELISKMAGVELEIVMDYEIAHTNISMKSNDMVEEERIKHQRQLIDQESATSTTTNGGDDIPAVVGWHYDSYPFVCVLMLSDTTNMIGGETSLRMGSGHNGKVAIVPSPTKGSANVLQGRLIEHIAPSPVGMSERITMVTSYRAKSPMMKDTSVLSTVKPEVNYGSRYNQFYGEWIDYRIKLMQKKLDLINLNTKCDANFWEFNKQKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNW4</accession>
    <name>C4YNW4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_02897</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNW4"/>
    <dbReference type="SMR" id="C4YNW4"/>
    <dbReference type="PaxDb" id="5476-C4YNW4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02897"/>
    <dbReference type="HOGENOM" id="CLU_025000_4_0_1"/>
    <dbReference type="OMA" id="RINWASK"/>
    <dbReference type="OrthoDB" id="8093034at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000599">
        <property type="entry name" value="Poly(A) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000764">
        <property type="entry name" value="Poly(A) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000804">
        <property type="entry name" value="Poly(A) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF5">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="79"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="173"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="412"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="255"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="270"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ44623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="510" mass="56676" checksum="8DF8266C728179C7" modified="2010-10-05" version="1">MSEPTQDQPQEQQSQEQQQQEQQQQQQQQQQQEHQPEQQQSTESSENESQQAQQPSSQDDEKQVNAASAKEGGREVSNKILYVGNLPKSASEETIQELFSVGGNPVKTIKILNDKNKAGFNYAFIEYDTNEVADMALNTLNGRLVDDVEIKVNWAFQSAAIAGNPNNTEEPLFNIFVGDLSPEVNDEGLRNAFSKFESLKQAHVMWDMQTSRSRGYGFVTFGNQSDAELALQTMNGEWLCGRAIRCNWASHKQQQQQQHYNNQHGGGYSRGYRNNNGGNNNNRQFRQFNNINNGNNNGFSQPLVNNNPQFIGQQPPQPDQHQHQQQQQQQQQQQSVNGANGVPQQMLQGLTNGNLGPGTPINGSNNAAGGFNNNGTAGNVAGAPVAGGPGAIPVMSPQSYDIVLRQTPSWQTTVYLGNIAHFTQQQELIPLLQNFGFIVDFKFHPERGCAFVKYDTHERAALAIIQLAGFNLNGRPLKCGWGKERPPQFQNFPRNGNMHQVPMYGPGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNX1</accession>
    <name>C4YNX1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_02904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNX1"/>
    <dbReference type="PaxDb" id="5476-C4YNX1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02904"/>
    <dbReference type="HOGENOM" id="CLU_370523_0_0_1"/>
    <dbReference type="OMA" id="PFIMFHY"/>
    <dbReference type="OrthoDB" id="4075894at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ44630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="762" mass="87097" checksum="CA31492E53ADF3E3" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPA2</accession>
    <name>C4YPA2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit H</fullName>
            <shortName evidence="4">eIF3h</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_03051</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit H family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPA2"/>
    <dbReference type="PaxDb" id="5476-C4YPA2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03051"/>
    <dbReference type="HOGENOM" id="CLU_044094_1_0_1"/>
    <dbReference type="OMA" id="WYQSTYF"/>
    <dbReference type="OrthoDB" id="10265695at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03007">
        <property type="entry name" value="eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="13"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ44761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="328" mass="37424" checksum="5A24BECA255051BA" modified="2009-07-28" version="1">MASKYTPATLNTVHISSSVSLSLLRHTSEHYPQLFSGALLGFEDESLIDVTHGFPYPYPDQYEGGSFRSRSGGQYQKDLLENFKKLGYGIEFLGWFQSTVSGNFVTNQLIEGLAQQQLINSNAFILINNLSSVGQEVSIKALRLSTGFMNAYVDGKWKSKDLESNKISYLNIFEELNLEISNQKLVDVYLSSLSLKPSTESELDVLNLLSNQNATGQLLESLSGQVDSFNYDQNNFNYYQRQYQKEQSKIQQWKQQRKLENLERAKKGEKELDTEEWKTIFKLPNEPSRYNNMLYSSAIDVLADDILKKCDEELTKSFAIERKLTASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPK0</accession>
    <name>C4YPK0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF895 domain membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_02401</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPK0"/>
    <dbReference type="SMR" id="C4YPK0"/>
    <dbReference type="PaxDb" id="5476-C4YPK0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02401"/>
    <dbReference type="HOGENOM" id="CLU_030884_1_2_1"/>
    <dbReference type="OMA" id="AYWFMGA"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06178">
        <property type="entry name" value="MFS_unc93-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000726">
        <property type="entry name" value="DUF895 domain membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ44139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="56571" checksum="0804B309D465E1BE" modified="2010-10-05" version="1">MEKDQTKMDINSNTSSSNKDLEVQPEHLELKHHTNAEIEASGSWIDKQINILGAKFRFSSAMCQIVLLAFVVFLTPGMFNALSGIGAAISDKKTADLANTALYVTFSTVGFFAGTICNVIGVKMSLVFGGFGYAIYAGSLLSFNHNENKGFVIFAGAFLGFCASLLWAAQGTIIMSYPTEQTKGRAIMVFWVIFNLGAVIGSIIPLAENMHNQGSSASDGTFIAFIILMICGSVLANFMLPISKVWKSDGTRVMTKTHPYWKDELIGLGRTLIKEPKILLMFPMFFASNWFYTYQFNNVNYGRFNLRTRSLNSLLYWLAQMFGAIVLGYILDFKKFKRSTRAKIGWAILFVTSLAIWGGGLKFQMSFTREEVESKPPKISQLDFKDGAYIGPMFLYIFYGVFDAIFQTYTIWVLGAMSNNPKKTALYAGFYKGIQSAGAAIAWRLDSLEVKYMSLFASSWGLVQGSLVLAIPLIFFMIKDHTALEDDNMGEVVDDAELDVVKSTTVHIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPK9</accession>
    <name>C4YPK9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPK9"/>
    <dbReference type="PaxDb" id="5476-C4YPK9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02410"/>
    <dbReference type="HOGENOM" id="CLU_1713009_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="153" mass="18851" checksum="A3EBFDF6036624DA" modified="2009-07-28" version="1">MLSVMETHKYHHLSATFHHQCQICHHRYHLTQWVFPLLVPFHILLFTKGIFLLHQLILLHSVITNLLTRFHQCHPQHLQLSRNHKYQHQRQYQYQHYNLTNHNPRLCGIHYIHHLLDCHLVNNNCKQYTHQPNQRNCHYYHNRDHLNRNPHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ68</accession>
    <name>C4YQ68_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inactive metallocarboxypeptidase ECM14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Inactive metallocarboxypeptidase ecm14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_02623</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Inactive carboxypeptidase that may play a role in cell wall organization and biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ68"/>
    <dbReference type="PaxDb" id="5476-C4YQ68"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02623"/>
    <dbReference type="HOGENOM" id="CLU_019326_1_0_1"/>
    <dbReference type="OMA" id="HQHAREH"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000060">
        <property type="entry name" value="Putative metallocarboxypeptidase ecm14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF147">
        <property type="entry name" value="INACTIVE METALLOCARBOXYPEPTIDASE ECM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946925" description="Inactive metallocarboxypeptidase ECM14" evidence="13">
        <location>
            <begin position="18"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="14">
        <location>
            <begin position="157"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ44357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="470" mass="54223" checksum="63F713BF099A7BA2" modified="2009-07-28" version="1">MNCIKLISLLLIQLVVTHQIQIPFNFNGLFSSKDVTRPHYTSVDPQYHPIDLSQYNDKHVVRIDYSNDPDLGKYLISSPLRGDANVHFAKWSHASNLKTIDIQIDKESLAKLHEMFPSMSFKVIVGDLAQKIFETYPSQVNQLNEDPVVANELFFKEYRSLETIDAWLGLLQATYPDIISVEEIGETYEHRKYKVVHFTVPSSEGNDDHGDRRTVVVSGGIHAREWISTSSVLYSIYALIEFYKNAPDSDIWSKLDFIFIPVSNPDGYEYTWTTDRLWRKNRQPTIHPKCFGIDIDHSYDYHWTRSSDWACGEEYSGEAPFEAFESQIWTEYLNNTNANHKIWGYIDLHSYSQEILYPYAFSCNEQPRDEENLLEVAWGLAKAIRMQSGTSYNVLPACIDRDADLMLDLGSGTALDYMYHHRADYAFQLKLRDTGNHGFLLPAKYIEPVGREVVAALKYLCNFLVDEQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQC1</accession>
    <name>C4YQC1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">STB6-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="19806at2759"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="STB2/STB2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25995">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="931"/>
            <end position="951"/>
        </location>
    </feature>
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        <location>
            <begin position="58"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="999" mass="114095" checksum="E34277AFE85BCEDA" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQE2</accession>
    <name>C4YQE2_CANAW</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YQE2"/>
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    <dbReference type="HOGENOM" id="CLU_050083_0_0_1"/>
    <dbReference type="OMA" id="LLCYAFP"/>
    <dbReference type="OrthoDB" id="73691at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ44431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="399" mass="46876" checksum="C0732C1DD8F68CD7" modified="2009-07-28" version="1">MNKSPRFYRLPSKKSVFLNELSKSPRLSLIWQSVDSRCMNATKTLPIVIQTKQEIFNQVVQSNPEKQGVSLKFKQFIAYGKAIINFYKSGIKNVWQNQSILKKLKQDFYLTHVAPSGQEIKIRIPSFKKLTEEMSQRIYMNKVESETLEKMTKGDIKRSNDMKTHSIFNLTREQFQLYKRTPNDYYKIPLFALVCLIFEELTPVLCYMIPEITPSTCILPNILPRVWNPNAIGKMKSLNQNLDENSMIDLSLKTSYNLDIEHVRLLSQSLRLVSRYIPPQFYPDGYLRDKLQDYYNYIVIDNFYLSGLNGDGNMWNLNDQELVLACLERNLIQNIVYDTKLFNQISDPIQKQMFQDKYMGKLRVKLFQYLVDFDSFNIGYLAVNHAIPREEEVNVIAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQG6</accession>
    <name>C4YQG6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_02724</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQG6"/>
    <dbReference type="PaxDb" id="5476-C4YQG6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02724"/>
    <dbReference type="HOGENOM" id="CLU_012062_9_2_1"/>
    <dbReference type="OMA" id="KRHLGFA"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="16"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="167"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="123"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ44455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="282" mass="32006" checksum="FE3E3C7A281309AC" modified="2009-07-28" version="1">MSTSEETKVTKPVIEDRIYVGNVDFKATEDELKELFQDLKVTEVEIPFKENTRGDKVFKRHLGFAFVQFENKDDADKAIATYNGQKFQRRNIFIKKAVPPPTEEEKKERVEAFKAKREEIKKAKEQKKAEAKKKREEATADAATTANGESATTDSTPAIPDGTPSKDTIFITNLDYKVNVKTLNSLFKELKPKWIHVPSRRVPYNRRGRGGKFRKPFNKGIAFVKFSNEETQKQAVAEFNGKEVNGREIIVDIAIDSRIPKEGSTEEDVDDEENAEANSNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQR6</accession>
    <name>C4YQR6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">diphosphoinositol-pentakisphosphate 1-kinase</fullName>
            <ecNumber evidence="3">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_04413</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="3"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQR6"/>
    <dbReference type="PaxDb" id="5476-C4YQR6"/>
    <dbReference type="HOGENOM" id="CLU_057544_0_0_1"/>
    <dbReference type="OMA" id="PITEKAM"/>
    <dbReference type="OrthoDB" id="18042at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000002">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VIP1 N-terminal" evidence="12">
        <location>
            <begin position="136"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ46069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="361" mass="40067" checksum="9CD6FCF9DB52A246" modified="2009-07-28" version="1" fragment="single">MTNNSKSLPIPVPKKEDAKSNSLNIPKSISQPLSPLSTPTPITEKAMASIAPMLESFSPKTHAEDSVSRLNSISSSAGQVSDDDLVQPITAENLSNIKSYSNSFVDGARISRTVSNTSNASRKSHAEVSKLPKIGTIGVCAMDAKALSKPCRRILNRLIETGEFETVIFGDKVILDEAIENWPTCDFLISFFSTGFPLDKAISYVNYRKPYMINDLVFQKALWDRRVVLSILNHANVPSPERLEISRDGGPHLDSQLLEKLKEIGMSDEKLEKLTNQNEPDWEMVDEDTLRVGDNTLSKPFVEKPVDGEDHNVYIYYPKATGGGGRRLFRKIGNKSSEFDANLTTPQTDGSFIYEKFMDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQU0</accession>
    <name>C4YQU0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="4 12">2.7.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_04437</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the APS kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="4 12"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQU0"/>
    <dbReference type="SMR" id="C4YQU0"/>
    <dbReference type="PaxDb" id="5476-C4YQU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04437"/>
    <dbReference type="HOGENOM" id="CLU_046932_1_0_1"/>
    <dbReference type="OMA" id="HENTVEE"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000212">
        <property type="entry name" value="Adenylyl-sulfate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055:SF1">
        <property type="entry name" value="PAPS SYNTHETASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="8 12 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APS kinase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ46093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="200" mass="22537" checksum="5D9973318F9175B6" modified="2010-10-05" version="1">MATNITWHANLTHQERAELRKQKGVTVWLTGLSASGKSTIACALEQSILARGLNSYRLDGDNIRFGLNKDLGFSEADRNENIRRISEVAKLFSDSCCITVTSFISPYRADRRLARELHEKDNLPFVEVYIDVPLEVAEQRDPKGLYKKAREGIIKEFTGISAPYEAPEKAEIHVKNHSGLSVEQAAEQIIDYLLEKGYIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR47</accession>
    <name>C4YR47_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">NEDD8-activating enzyme E1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_04546</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR47"/>
    <dbReference type="PaxDb" id="5476-C4YR47"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04546"/>
    <dbReference type="HOGENOM" id="CLU_019618_2_1_1"/>
    <dbReference type="OMA" id="KLITHQY"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01493">
        <property type="entry name" value="APPBP1_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000475">
        <property type="entry name" value="NEDD8-activating enzyme E1 regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF29">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039099">
        <property type="entry name" value="APP-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="8">
        <location>
            <begin position="9"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ46200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="537" mass="61220" checksum="8C5FF58E637D55B5" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRQ8</accession>
    <name>C4YRQ8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRQ8"/>
    <dbReference type="PaxDb" id="5476-C4YRQ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04762"/>
    <dbReference type="HOGENOM" id="CLU_2512402_0_0_1"/>
    <dbReference type="OMA" id="IENKHYP"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946852" evidence="2">
        <location>
            <begin position="19"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="84" mass="7667" checksum="809CC6242DCEF7E6" modified="2010-10-05" version="1">MQFTKVIASLALVASINAKFHNTTGAAAGNGTVAGGSNSTGGAGSHNGTGASNGSSSKSSGSGAAVNSVTGLAALAAVGAALLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS05</accession>
    <name>C4YS05_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_04863</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS05"/>
    <dbReference type="PaxDb" id="5476-C4YS05"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04863"/>
    <dbReference type="HOGENOM" id="CLU_004517_1_0_1"/>
    <dbReference type="OMA" id="ISACNRC"/>
    <dbReference type="OrthoDB" id="2399539at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14723">
        <property type="entry name" value="ZIP_Ppr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ46508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="852" mass="98019" checksum="A579391459F4878C" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS19</accession>
    <name>C4YS19_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_04877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS19"/>
    <dbReference type="PaxDb" id="5476-C4YS19"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04877"/>
    <dbReference type="HOGENOM" id="CLU_362947_0_0_1"/>
    <dbReference type="OMA" id="TCSQIFM"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060628">
        <property type="term" value="P:regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.670:FF:000015">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1420">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007528">
        <property type="entry name" value="RINT1_Tip20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042042">
        <property type="entry name" value="Tip20p_domB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520:SF0">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1 RINT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04437">
        <property type="entry name" value="RINT1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51386">
        <property type="entry name" value="RINT1_TIP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="784" mass="91157" checksum="AD55B43201536A12" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS32</accession>
    <name>C4YS32_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_04890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS32"/>
    <dbReference type="PaxDb" id="5476-C4YS32"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04890"/>
    <dbReference type="HOGENOM" id="CLU_787549_0_0_1"/>
    <dbReference type="OMA" id="PCTCHCH"/>
    <dbReference type="OrthoDB" id="4015084at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="314" mass="35749" checksum="74FB9DF5B5E0F797" modified="2009-07-28" version="1">MESISHKYRDLKFRVNHLLVAYRQRYYSTHKNPRVIQSRVQNQQLLSLRTFPKDPYLTGSDKPFLHLSNEYEETESQYLDNSDERDYTLFEYTNDMSSKAHDSATPGKSYSEPNFGEGYFSTFRLELPINPSSDEQHQEITQFDPTQPAEQCEPLLDMSITTDEYLSGSSISPVSFPCTCHCHTFEKIAPQSSTNKRNHNVKEKLYDFVVNNFSKVTGQGNDTVATISSNIETFTPLDIQATDSIETVPDKTDPTKGTDRIWKLVLNDVSLSAARLSTGSSNIPVVNNQNIRGDFINAKVKTITNNENEDIFNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSC7</accession>
    <name>C4YSC7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="9 10">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_04990</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 9">Belongs to the PPP phosphatase family. PP-Z subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9 10"/>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSC7"/>
    <dbReference type="PaxDb" id="5476-C4YSC7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04990"/>
    <dbReference type="HOGENOM" id="CLU_004962_4_0_1"/>
    <dbReference type="OMA" id="HKLWKNF"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000026">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011159">
        <property type="entry name" value="PPPtase_PPZ/Ppq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
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            <end position="392"/>
        </location>
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    <sequence length="571" mass="63558" checksum="02DD32AEBD0B81D8" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSE7</accession>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
    <sequence length="692" mass="78679" checksum="3921B8941F46E8A2" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
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    </organism>
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                <person name="Forche A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="20"/>
        </location>
    </feature>
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            <begin position="21"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="167" mass="18330" checksum="BE17632C486B9521" modified="2010-10-05" version="1">MKFATITSIAIVALAQSATALRTVTLKTFGYPPPQYPEVTGKSVSAWHEGAGINYLLIAEPATKFTYDEESKHLYFEGGQGPNGPLKWYFTIGDGEPGILQANPTDHPTEITIDNLGFITFEGSYNVKGVKNIDDPYNYSKDHYVLAKYDKEAPSDAVPVFFQAIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSY8</accession>
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            <taxon>Candida</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ISY1 family.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ47124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="266" mass="31987" checksum="3625274567C68EC4" modified="2009-07-28" version="1">MSRNKEKAQSSLNRFYQSQSSAPINYHYHQRPKNIHSITQLSQAEGWRRSIIGEISKQLTEINDFEISDIKVRELNDQLNELFNEKRRWEYHIRDKLHGNDYIRHNGNTKNDLINTGIRVNNSDKGKYYRYFGRAKDLPEVKLLIEENKKNRKNHKRNDIDDSDQSKRRRKVDQYKSTDNSIDMNYYGFYDEEEDEYLDDSEAQLGDPLVVYEEKRTKELNDAEIQQQDTENLEQIRMSFNDIPTNEVVTKWLVNKRREQLLSKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSZ0</accession>
    <name>C4YSZ0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSZ0"/>
    <dbReference type="PaxDb" id="5476-C4YSZ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05687"/>
    <dbReference type="HOGENOM" id="CLU_882766_0_0_1"/>
    <dbReference type="OrthoDB" id="4024167at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="326" mass="35964" checksum="498F2751178B1F73" modified="2010-10-05" version="1">MSILINNGNDYQLNSSETFNSLKSSPSSTSSLSSISTSSSSSCHKRSKAVDLNRNTSNSQNSSISTAPTTATAANTTPRKTSITIPSKLPSSWIPLRNGNIDYSRYYNTNQEEDNQEQQLQDGEPLSAPTTNNGTTKTATANANIIQDSFETIPCFSSTTNTTITSSRSNPTNSTPTSNDPSFPKQMINWNQFLQEEKDMNDNSSTINDDDKTFYMEQLNLNVGQTPNNNNNNNHGVSETENDLLPGTSKSLIAKYHYQLNYGDENENETNDVREYEYGGGESRKRKSSTTSDDRRPRRGGGGGGSRTSQVFRNTLNKFTFKPKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSZ8</accession>
    <name>C4YSZ8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_05695</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSZ8"/>
    <dbReference type="PaxDb" id="5476-C4YSZ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05695"/>
    <dbReference type="HOGENOM" id="CLU_004553_2_0_1"/>
    <dbReference type="OMA" id="PEMAFYD"/>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04318">
        <property type="entry name" value="EcAsnRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003037">
        <property type="entry name" value="PRK03932.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="8">
        <location>
            <begin position="157"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ47134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="486" mass="55180" checksum="86CBD3E80580076D" modified="2009-07-28" version="1">MLIQSRFPLKALQQVSSKRFNSSSLNPTIKNQLSNPPPIGSIIEARGFVKSIRSSKKVGFVDITDGSISNNLNIVLQGPDQPKFKVGQSIVVKGDWTVGKGKQPFELKYNPENPQHAITILGDVTDDYPLQKKATSMSFLRNFPEIKHRTSTLGSFLRLRSHLEFKLMEFFQSRDFIKVTPPLITSSDCEGAGEVFKIEPLNPKEPFFGKNAYLTVSTQLHLECLALALNRAWTLTPCFRAENSNTTRHLSEFWMLEAEISHVDNMDQVTTFTEDMIKFVTRSLVESSHSTELSDLGAGNGNDYLNGTYIEKDVVQSRWSNILSAERWPRMTYTEAIEYLNKTLPQDEQLIWGDSLQLKHERLLAEKSPIFITDYPESQKPFYMLKSANYNAENPTVTCFDLLVPEFGELAGGSMREHDYQVLLANMKQENMNIEDMEWYLNLRKQGTIPHGGFGLGFERLISYLAGYDNVRDISAFPRAPELCNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT44</accession>
    <name>C4YT44_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_05743</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT44"/>
    <dbReference type="SMR" id="C4YT44"/>
    <dbReference type="PaxDb" id="5476-C4YT44"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05743"/>
    <dbReference type="HOGENOM" id="CLU_000134_20_0_1"/>
    <dbReference type="OMA" id="EAENVGW"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24188">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24188:SF29">
        <property type="entry name" value="GH09064P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ47180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="212" mass="23853" checksum="7E19C5282280E785" modified="2010-10-05" version="1">MSEITKLTQEEMDVVIYDSRVGDLETLQEIFDLEKLITPKTLTIIKDDITLSTPLHMAAANGHLPVVKYLISLLEKDDVKQLLEAKNENGNTALHWASYNGHLEVVEYLVEEVNADPFIKNNSGHDCIYEAESGGQTEVENWYLKKFTPEDAFDVQENEAEGTTKITYQPGKESKLADDQARDAVFKSKLDNTSTEGDSLEQKTQALNIDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT51</accession>
    <name>C4YT51_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cysteine synthase 1</fullName>
            <ecNumber evidence="5">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">O-acetylserine (thiol)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">O-acetylserine sulfhydrylase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">O-succinylserine sulfhydrylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAWG_05750</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-succinyl-L-serine + hydrogen sulfide = L-cysteine + succinate</text>
            <dbReference type="Rhea" id="RHEA:53816"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:136856"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT51"/>
    <dbReference type="SMR" id="C4YT51"/>
    <dbReference type="PaxDb" id="5476-C4YT51"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05750"/>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_1"/>
    <dbReference type="OMA" id="VVTVFWD"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000011">
        <property type="entry name" value="Cysteine synthase (o-acetylserine)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007989">
        <property type="entry name" value="PRK10717.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="19">
        <location>
            <begin position="34"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEQ47187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="365" mass="39336" checksum="586B1BCFDAA9AB02" modified="2010-10-05" version="1">MLGRIAKRSISITTNTPLKLPFIPLVSETGFPGAIGNTPLLKLPRISESINRNIYAKAEFMNPGGSIKDRAALYIIKDAEEKGLIKPGGTIVEGTAGNTGIGLAHVCRARGYKCIIYMPNTQSQNKIETLRLLGAEVHPVPAVAFTDPENYNHQAKRHAERLDNAVWTNQFDNVANRQAHIETTGPEIWAQLDGKVDAFTCSTGTGGTFAGTTRYLKDISNGKVKAVLADPPGSVLYSYIKSGGKEMIRGGSSFTEGIGQGRVTDNLQPDLELVDDAVKIPDEDSIAMVYRLLDEEGLYLGGTGALNVAAAVEVAKSLPEGSNVVTVLADSAHKYADRIFSKKWLAEKGLYDAIPPHLQKYAVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT58</accession>
    <name>C4YT58_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">catechol O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_05757</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="1"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT58"/>
    <dbReference type="PaxDb" id="5476-C4YT58"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05757"/>
    <dbReference type="HOGENOM" id="CLU_050461_0_0_1"/>
    <dbReference type="OMA" id="VEITRCV"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF2">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ47194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="248" mass="28284" checksum="3AA6CEF48F81E5AE" modified="2009-07-28" version="1">MSKETEFYNYITTLPETTLSQVRGKPHEVLKLIDEYPQNFMNIGPHKGKQIVTRIKEKAPKTMIELGGYLGYSAVLFANEIADDPDAKYYSFELNPEFAKIATYVIDLAGLSDKVEIIVGRASYTLPAFRQRLFSENKHYTGLDFIFIDHWKDLYVPDLRVLESLNLIAPGTLIVADNIITPGAPEYVVYVNFSPDEKKLYNETTKNPEGKEFIGRWNILYDTKTIEVATANHKDAIEVTKCFDYFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTK1</accession>
    <name>C4YTK1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bola-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTK1"/>
    <dbReference type="PaxDb" id="5476-C4YTK1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05495"/>
    <dbReference type="HOGENOM" id="CLU_109462_0_1_1"/>
    <dbReference type="OMA" id="EDIAKWH"/>
    <dbReference type="OrthoDB" id="203381at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052275">
        <property type="entry name" value="Mt_Fe-S_assembly_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188:SF1">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="14304" checksum="369DB75A939F2C29" modified="2009-07-28" version="1">MIRNNIIRNICLSNIYKYNSSINQRTISPFLSSKRNYSTSQEESEPMDEYESKIYNILQQELNPVNLKIKDVSGGCGSMFSIFIESEKFKGLTMIKQHRLVNEILKDEIKKWHGLQLRTKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTK7</accession>
    <name>C4YTK7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_05502</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTK7"/>
    <dbReference type="PaxDb" id="5476-C4YTK7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05502"/>
    <dbReference type="HOGENOM" id="CLU_001265_52_4_1"/>
    <dbReference type="OMA" id="TWRNYTL"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="84"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ46948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="545" mass="60454" checksum="F64EDF0D7B538ED2" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTL1</accession>
    <name>C4YTL1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bem2p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_05506</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YTL1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05506"/>
    <dbReference type="HOGENOM" id="CLU_002085_0_0_1"/>
    <dbReference type="OMA" id="TLEDDRW"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037769">
        <property type="entry name" value="Abr/Bcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23182">
        <property type="entry name" value="BREAKPOINT CLUSTER REGION PROTEIN BCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23182:SF1">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 1A, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="4">
        <location>
            <begin position="1084"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="1715"/>
            <end position="1827"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="1848"/>
            <end position="2043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="928"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1662"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2047"/>
            <end position="2232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="928"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="939"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1671"/>
            <end position="1699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2048"/>
            <end position="2057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2063"/>
            <end position="2081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2082"/>
            <end position="2169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2178"/>
            <end position="2199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2212"/>
            <end position="2223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ46952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2245" mass="257847" checksum="B6283BB7703A4C15" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTP7</accession>
    <name>C4YTP7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTP7"/>
    <dbReference type="SMR" id="C4YTP7"/>
    <dbReference type="PaxDb" id="5476-C4YTP7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05542"/>
    <dbReference type="HOGENOM" id="CLU_927850_0_0_1"/>
    <dbReference type="OMA" id="WHNKYYG"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051938">
        <property type="entry name" value="Apopto_cytoskel_mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145:SF3">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="17"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="287" mass="33404" checksum="B3F3CCA32C7420F0" modified="2009-07-28" version="1">MINSIRLLSTQASNNLTHYQILDIPATASIKEIKLQFKKLSKKYHPDLNQHLSDDERDAIKEKYMQMISSYEVLKDLKRKKAYDQSINLNHKREWNNKYYGEAKYHSKTNKSYNYTSSGLNTKRHKVRFHNGYTPDNTNANAKFTGEHVNYGDRYDVPHFDYEKHLNRNLKFEQRLIDKYLDQSTQTKILNQITRSNHDDISQELKTKHLLRHVNMIRNTNTSYSGSTSSPKYGESTTFNGSSASTAFHQNIYQKPRSTDEDSSMFKAFAILGGAGSSLYLLYQVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTQ2</accession>
    <name>C4YTQ2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inheritance of peroxisomes protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_05547</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for peroxisome inheritance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTQ2"/>
    <dbReference type="PaxDb" id="5476-C4YTQ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05547"/>
    <dbReference type="HOGENOM" id="CLU_025507_0_0_1"/>
    <dbReference type="OMA" id="YWKIFIN"/>
    <dbReference type="OrthoDB" id="4097008at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005780">
        <property type="term" value="C:extrinsic component of intraperoxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045033">
        <property type="term" value="P:peroxisome inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024758">
        <property type="entry name" value="Inp1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12634">
        <property type="entry name" value="Inp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="96"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="230"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="378"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ46993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="772" mass="88767" checksum="DF6FAA8B602A28B2" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTV9</accession>
    <name>C4YTV9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_05605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTV9"/>
    <dbReference type="PaxDb" id="5476-C4YTV9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05605"/>
    <dbReference type="HOGENOM" id="CLU_091746_0_0_1"/>
    <dbReference type="OMA" id="QFWLEID"/>
    <dbReference type="OrthoDB" id="1057137at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039683">
        <property type="entry name" value="Lsm12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13542">
        <property type="entry name" value="LSM12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ47050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="222" mass="25258" checksum="FADCD129B0FA9776" modified="2009-07-28" version="1">MSFQNFDQIINLKVKIITLLDQIIIGQIYTYSSSNEIIIIKTKTNTNDNKQNSSSTSTYRIYNTAFIKSIQVLPPFSRKNGNNKSDSSSSSSSSSASTLLEFINMNDLDKRLKREVNNYKPQPIQQQQASHTQPSNISTLLFNRLVKLYGDKNVKFGNGNNSTTSTKQSEIIIFNEIKIIKPFTNIKSNIQIIKENGKKHLDSIQRALNQFWLEIDNEKRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTW7</accession>
    <name>C4YTW7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA polymerase</fullName>
            <ecNumber evidence="20">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CAWG_05613</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19 20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="20"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTW7"/>
    <dbReference type="PaxDb" id="5476-C4YTW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05613"/>
    <dbReference type="HOGENOM" id="CLU_000203_2_0_1"/>
    <dbReference type="OMA" id="CNNCRPR"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05777">
        <property type="entry name" value="DNA_polB_delta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05533">
        <property type="entry name" value="POLBc_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000351">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 20" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 20" id="KW-0235">DNA replication</keyword>
    <keyword evidence="17 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14 20" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 20" id="KW-0408">Iron</keyword>
    <keyword evidence="16 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="22">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="21">
        <location>
            <begin position="286"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="23">
        <location>
            <begin position="753"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EEQ47058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="849" mass="97173" checksum="9C2FF06AD02A4F6D" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTZ1</accession>
    <name>C4YTZ1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 14">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_05639</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTZ1"/>
    <dbReference type="PaxDb" id="5476-C4YTZ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05639"/>
    <dbReference type="HOGENOM" id="CLU_034302_6_1_1"/>
    <dbReference type="OMA" id="WSYILWQ"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ47082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="200" mass="23245" checksum="E68F6BFD9D6F0DDF" modified="2010-10-05" version="1">MSQPNKWLIAYNSISASLWSIVLFNTVFLSLTLGQPYVFEKTNKTTTAIQTLAVVEIVNSLLGLVKSPLFTTVTQVFSRLLIVWGIHQYLPDSPANYHWCYITLCLSWSITEIIRYSYYASNLTGQVPFWLTWLRYTTFYVLYPTGVFSEVCSVILSLNEAGFYYGWILKIILVVYIPGFYMLYTYMIKQRKKVLNKKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C5K450</accession>
    <name>C5K450_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein N-terminal and lysine N-methyltransferase EFM7</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM7</name>
        <name evidence="6" type="ORF">CAWG_06153</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="GG670279">
        <property type="protein sequence ID" value="EEQ43132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C5K450"/>
    <dbReference type="PaxDb" id="5476-C5K450"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06153"/>
    <dbReference type="HOGENOM" id="CLU_032409_0_0_1"/>
    <dbReference type="OrthoDB" id="46564at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Unplaced Supercontig 1.11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03223">
        <property type="entry name" value="Methyltr_EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025784">
        <property type="entry name" value="EFM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF10">
        <property type="entry name" value="PROTEIN N-TERMINAL AND LYSINE N-METHYLTRANSFERASE EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51560">
        <property type="entry name" value="SAM_MT_NNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ43132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="262" mass="30404" checksum="13F5B12CDDF0CF27" modified="2009-07-28" version="1">MSEDEISIEGDLFEEPEGFLPERPSSHFSTYKRKIPNAEPQEITMKLVGHNPLYGHLLWNAGIYTADYLDKHSDTLVKGKKILELGAASALPSLVCSLNHAKEVIVTDYPDPDLLSHMEYSFNDLKEKTKYELSPWKVKGYIWGHDLGELLFDEPGRKLAEEEKFDLIILSDLVFNHSEHHKLLDTCRQSLKRNGGKCLVVFSPHRPHLLQDDLSFFETAKQYQFKTEKIEMVTWKPMFEEDEETADIRARVYAFFLIPEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C5K455</accession>
    <name>C5K455_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_06158</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG670282">
        <property type="protein sequence ID" value="EEQ43137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C5K455"/>
    <dbReference type="PaxDb" id="5476-C5K455"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06158"/>
    <dbReference type="HOGENOM" id="CLU_021752_0_0_1"/>
    <dbReference type="OrthoDB" id="271164at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07627">
        <property type="entry name" value="BAR_Vps5p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06861">
        <property type="entry name" value="PX_Vps5p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000013">
        <property type="entry name" value="Putative Sorting nexin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000022">
        <property type="entry name" value="Sorting nexin 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035803">
        <property type="entry name" value="BAR_Vps5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037868">
        <property type="entry name" value="PX_Vps5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="270"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="48"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="180"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="568"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ43137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="672" mass="76075" checksum="7429274BAFFE51B9" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-11-01" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>P46596</accession>
    <accession>C4YG24</accession>
    <name>OPS4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>Opaque-phase-specific protein OP4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">OPS4</name>
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        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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            <taxon>Candida</taxon>
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    </organism>
    <reference key="1">
        <citation type="journal article" date="1993" name="Infect. Immun." volume="61" first="1823" last="1828">
            <title>Coordinate regulation of two opaque-phase-specific genes during white-opaque switching in Candida albicans.</title>
            <authorList>
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                <person name="Srikantha T."/>
                <person name="Anderson J."/>
                <person name="Soll D.R."/>
            </authorList>
            <dbReference type="PubMed" id="8478072"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
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                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    <proteinExistence type="inferred from homology"/>
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            <begin position="1"/>
            <end position="20"/>
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    <feature type="chain" id="PRO_0000021917" description="Opaque-phase-specific protein OP4">
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            <end position="402"/>
        </location>
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        <variation>V</variation>
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    <feature type="sequence conflict" description="In Ref. 1; L10735." evidence="3" ref="1">
        <original>S</original>
        <variation>D</variation>
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            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="402" mass="41328" checksum="33B7019E263AB240" modified="2011-10-19" version="2" precursor="true">MKFSQATILAIFASSALVSAAPANIVSEQTMVKREDVNAIVELINEIKHINQKRDLAEGEDLLELQRRADSVIGELVSALYNSGVIGLVWDKLTTDPSISSSLSNIIKSAIQGAIVQGGALIQAVWNSGLLGDVFNKLINDTDLRQALLDVGKALFNSAANLISIWLGGSSSSSSAAPAAAAAPATNGASKREIMEAAEYLSERDLASILSWIVQTIKDTGIVQSLVNQVINNPDTVISFLTSALKNGLVIVEDLYDWAKQSGLWDQALVYIQNNAGSWIKALAGLFGNALSNGTITASDINNAGSSSKPTGTTTASTATAAPKAATPAAASAAAPKAATSGSSSGSSSNNADLNALINKYGGGSGSTSTPTVDTSGLSSDVNTLVNAAGQAASSLKKRKLY</sequence>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
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                <person name="Costanzo M.C."/>
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                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
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            <strain evidence="3 4">WO-1</strain>
        </source>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000001429"/>
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    </evidence>
    <sequence length="831" mass="94303" checksum="89F6BB23B93D91F6" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
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                <person name="Sakthikumar S."/>
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                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
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                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
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                <person name="Lennard N."/>
                <person name="Logue M.E."/>
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                <person name="Lorenz M.C."/>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17 18">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18 19">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="5 18"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCS7"/>
    <dbReference type="PaxDb" id="5476-C4YCS7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00311"/>
    <dbReference type="HOGENOM" id="CLU_049944_5_0_1"/>
    <dbReference type="OMA" id="HGCGMIS"/>
    <dbReference type="OrthoDB" id="448573at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000022">
        <property type="entry name" value="CDP-diacylglycerol--serine O-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016271">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF61">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000852">
        <property type="entry name" value="Phosphatidylserine_synth_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 18" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EEQ42113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="273" mass="30761" checksum="BE722506BDBEA79F" modified="2010-10-05" version="1">MTDSSATGFSKHQESAIVSDSEGDAIDSELHMSANPPLLRRSSSLFSLSSKDDLPKPDSKEYLKFIDDNRHFSMIRNLHMADFITLLNGFSGFYSIISCLRYTLTGQTHYVQRAHFFILLGLFFDFFDGRVARLRNKSSLMGQELDSLADLVSFGVSPATIAFAIGFRTTVDVLFLAFWVLCGLTRLARFNISVNNIPKDKHGKSQYFEGLPIPTNLFWVGFMALLVYKDWIHDNLPFGIVFQDTSFEFHLVTIGFVLQGCAEISKSLKIPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD29</accession>
    <name>C4YD29_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_00417</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD29"/>
    <dbReference type="SMR" id="C4YD29"/>
    <dbReference type="PaxDb" id="5476-C4YD29"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00417"/>
    <dbReference type="HOGENOM" id="CLU_039456_1_0_1"/>
    <dbReference type="OMA" id="KMYIEEG"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000024">
        <property type="entry name" value="MIR1p Mitochondrial phosphate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF12">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="15"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="114"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="213"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ42215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="307" mass="32521" checksum="EC08791BC7048393" modified="2010-10-05" version="1">MSTPSEYKLPEYTVKDYASFALAGAIGCGATHGAMTPIDVVKTRIQLEPTVYNKGMLGSFKQVIKSEGAGALLTGLGPTILGYSLQGAFKFGGYELFKKTFIEYLGYDTAKQYKDSIYIGSSALAEFFADIALCPLEATRIRLVSQPTFANGLIGGFSRILKEEGVGSFYNGFTPILFKQIPYNIAKFLVFERANEAIYNAIPTPKVDLSTAAHTAVNLGAGIIAGCAAAIVSQPADTLLSKVNKTKKAPGQSTVGLLIQLAKQLGVSGSFAGLPTRLVMVGTLTSLQFTIYGSLKKALNCPPAVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDG9</accession>
    <name>C4YDG9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_00564</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDG9"/>
    <dbReference type="SMR" id="C4YDG9"/>
    <dbReference type="PaxDb" id="5476-C4YDG9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00564"/>
    <dbReference type="HOGENOM" id="CLU_079101_3_0_1"/>
    <dbReference type="OMA" id="KIITATW"/>
    <dbReference type="OrthoDB" id="1915122at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040153">
        <property type="entry name" value="Rcf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018:SF3">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="6">
        <location>
            <begin position="88"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ42355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="213" mass="24341" checksum="BCC8C091FF568D96" modified="2010-10-05" version="1">MKILSKEEKDAHISHIISEGAKGLFYGGALSVGLYQYLKHRHPARFATFNPSIKAAIIAMPTISVAAFFADQGSVEFDRKMHQSEYQEAKYLEEYREWNRLSLSDKCFTVLNDNKYKIIISAWAGSLYGSWVLVNRDKIMDTAQKAVQARMYAQGITIILLLGTLLLAMKEEEINKKKPKPIPEWKRIIMEKEAEDKRLVDEANKVAQEKATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDT0</accession>
    <name>C4YDT0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 ubiquitin ligase complex SCF subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_00678</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDT0"/>
    <dbReference type="SMR" id="C4YDT0"/>
    <dbReference type="PaxDb" id="5476-C4YDT0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00678"/>
    <dbReference type="HOGENOM" id="CLU_059252_4_0_1"/>
    <dbReference type="OMA" id="DKYTASM"/>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000133">
        <property type="entry name" value="Suppressor of kinetochore protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="4"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="4">
        <location>
            <begin position="114"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ42466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="164" mass="19060" checksum="EE12D803AA1A1E7E" modified="2010-10-05" version="1">MSSPKVIIVSSDNEKFPVEPKIAEKSILIKNMINDLHPDGLEEDFEIPTPNVRANVLCKVLEWCEHHKNTVFQDDEDEDAKKSVPVEEWDRNFLKVDQEMLYEIILAANYLNIKPLLESGCKMVAEMIKSKSPEELRRTFNIINDFSPEEEAAIRKENEWAEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDU0</accession>
    <name>C4YDU0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">General transcription and DNA repair factor IIH subunit TFB5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_00688</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TFB5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDU0"/>
    <dbReference type="SMR" id="C4YDU0"/>
    <dbReference type="PaxDb" id="5476-C4YDU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00688"/>
    <dbReference type="HOGENOM" id="CLU_166246_3_2_1"/>
    <dbReference type="OMA" id="IYNPMDE"/>
    <dbReference type="OrthoDB" id="354at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006294">
        <property type="term" value="P:nucleotide-excision repair, preincision complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1220:FF:000002">
        <property type="entry name" value="RNA polymerase II transcription factor B subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1220">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035935">
        <property type="entry name" value="TFB5-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009400">
        <property type="entry name" value="TFIIH_TTDA/Tfb5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06331">
        <property type="entry name" value="Tfb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01395">
        <property type="entry name" value="Tbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142897">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ42476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="69" mass="7767" checksum="FB2E15632254DA25" modified="2009-07-28" version="1">MLVASKGVLVQCDPSIKALIIQIDSSSSGIILEELDETHLLIQHDKVNFVKSELNRLLSKNIYNPFEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEJ5</accession>
    <name>C4YEJ5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Uridylate kinase</fullName>
            <shortName evidence="9">UK</shortName>
            <ecNumber evidence="9">2.7.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:UMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxycytidylate kinase</fullName>
            <shortName evidence="9">CK</shortName>
            <shortName evidence="9">dCMP kinase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Uridine monophosphate kinase</fullName>
            <shortName evidence="9">UMP kinase</shortName>
            <shortName evidence="9">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">URA6</name>
        <name evidence="11" type="ORF">CAWG_00952</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UMP + ATP = UDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <text evidence="9">Predominantly cytoplasmic.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.14" evidence="9"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEJ5"/>
    <dbReference type="PaxDb" id="5476-C4YEJ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00952"/>
    <dbReference type="HOGENOM" id="CLU_032354_0_0_1"/>
    <dbReference type="OMA" id="EQTMPVI"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000315">
        <property type="entry name" value="Adenylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03172">
        <property type="entry name" value="Adenylate_kinase_UMP_CMP_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006266">
        <property type="entry name" value="UMP_CMP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057781">
        <property type="entry name" value="YKL023C-A-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01359">
        <property type="entry name" value="UMP_CMP_kin_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23521">
        <property type="entry name" value="YKL023C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="9">
        <location>
            <begin position="120"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="9">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="100"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="148"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="178"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ42731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="279" mass="30869" checksum="E859AF7F55FB3C8F" modified="2009-07-28" version="1">MFSRQILAGRQIVSTFAKQKAVSQCIKRFNSSKTNSTPPPKYSKGKLLAVLGTLAIGSTIAASFYNKETPKSAFEPNESGDKPEFAEGKVSVIFVLGGPGSGKGTQSDKLVKEKGFVHLSAGDLLRAEQNRPGSKYGELIAKYIREGEIVPQEVTVALLKQAIKENYEQGKTKFLVDGFPRKMDQALTFENTIAKSAFTLFFECPEQVMLERLLERGKTSGRADDNIESIKKRFRTFIDTSMPVVDYFDKQGKVIKVRCDQPIDVVANQVKDALKTRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEQ7</accession>
    <name>C4YEQ7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">cystathionine gamma-synthase</fullName>
            <ecNumber evidence="10">2.5.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">O-succinylhomoserine (thiol)-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_01015</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-succinyl-L-homoserine + L-cysteine = L,L-cystathionine + succinate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20397"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57661"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="EC" id="2.5.1.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-cystathionine from O-succinyl-L-homoserine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the trans-sulfuration enzymes family. MET7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.48" evidence="10"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEQ7"/>
    <dbReference type="PaxDb" id="5476-C4YEQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01015"/>
    <dbReference type="HOGENOM" id="CLU_011302_1_0_1"/>
    <dbReference type="OMA" id="KVAKRCR"/>
    <dbReference type="OrthoDB" id="10047078at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000111">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000063">
        <property type="entry name" value="Probable cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ42793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="595" mass="67139" checksum="F8F554D03C74DB0D" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFL9</accession>
    <name>C4YFL9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hmx1p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_01337</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFL9"/>
    <dbReference type="PaxDb" id="5476-C4YFL9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01337"/>
    <dbReference type="HOGENOM" id="CLU_049906_0_0_1"/>
    <dbReference type="OMA" id="FAFAFQM"/>
    <dbReference type="OrthoDB" id="652091at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720:SF0">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000343">
        <property type="entry name" value="Haem_Oase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00088">
        <property type="entry name" value="HAEMOXYGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000343-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ43100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="33938" checksum="990FC7A7BA47BF9D" modified="2009-07-28" version="1">MQYKSSGATSKLSQVEIIPAKTDVGALANRINLETRSLHDRADKTVTLKFALALRNYKVYRQGLQAFYHVFASIEKALYRQLEKKDEWSEMLEQVWKPEIARAGKAEQDLLFFYDDNKEKFIKPIMPAQIEFCKHILEVTEEKPYLLFAYLHVMYLALFAGGRIMRSSVLKATGMYPQRDGLSHDDVVRMGTNFFTFDVPDEDLLRLTYKRDYELVTRNGLTEEQKLEIIEESKYIFEHDVKCVAELEKHNMDKLSGTWTYFLVTRGYYAALVLLSLLALIYLRRVVNKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFR3</accession>
    <name>C4YFR3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial import inner membrane translocase subunit TIM16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit tim16</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 13">Presequence translocated-associated motor subunit PAM16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_00039</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14. May act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM16/PAM16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFR3"/>
    <dbReference type="SMR" id="C4YFR3"/>
    <dbReference type="PaxDb" id="5476-C4YFR3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00039"/>
    <dbReference type="HOGENOM" id="CLU_101461_0_1_1"/>
    <dbReference type="OMA" id="RMFKIND"/>
    <dbReference type="OrthoDB" id="10262892at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000006">
        <property type="entry name" value="Import inner membrane translocase subunit TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005341">
        <property type="entry name" value="Tim16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388">
        <property type="entry name" value="MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ41852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="121" mass="13306" checksum="09757E9A43DD8E03" modified="2009-07-28" version="1">MAHRLLVNVIFTGASVFGRAFTEAYRQAAKASAAGAAGRPAKASSAGGIPVEEAMKILDLEKSELSLDKVEEKYEYLFNVNSKEQGNSFYLQSKVYYAMDTLKKELEYLEKLQNEKGAASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG80</accession>
    <name>C4YG80_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YG80"/>
    <dbReference type="PaxDb" id="5476-C4YG80"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00201"/>
    <dbReference type="HOGENOM" id="CLU_1992297_0_0_1"/>
    <dbReference type="OrthoDB" id="347657at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="125" mass="13591" checksum="D8EB0EEAD507B28B" modified="2009-07-28" version="1">MFKMKLQSGTPKRKPPPPVNPPQELNSHTGLPRRSTENGTLHAAQLAVSQVSPKGYSNNRRSSFTKEDGSKIDPNKMRKAAHTYNHSHSHNGNNGNSNSNSNGNKSGSGVTALNSKFLARSTRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGB2</accession>
    <name>C4YGB2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGB2"/>
    <dbReference type="PaxDb" id="5476-C4YGB2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00233"/>
    <dbReference type="HOGENOM" id="CLU_606901_0_0_1"/>
    <dbReference type="OMA" id="EHIANEN"/>
    <dbReference type="OrthoDB" id="4024803at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="213"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="451" mass="51857" checksum="9291813477FE199F" modified="2009-07-28" version="1">MEETIDRIPKLKKNITELRPEIVDKMERRANLSISDTFASSNIYSGTITSAKSINVVRFIDQSKGNDSFRDGNVFCNQVEVFKSTIQNGLRSICECLKINPDAHISEQEVVCVIISGIKALQLKYSSELKTNTQLKNDNETLIIAVNNQKADAEHIANENKEIKRQNHDIYKTVTMLDRELGNHEIESAAKTKELQSRILALNKEVFQIKEGEEKQRSENLKLLQNIAELQKLETKVNELTNENKSLETKNTTLKKLTKEKENKIDKLSSQLTSSRSKYASKLKSLESETGKTIDSLLVELKLVKDINEKLLAKDASTMETLKGVSTTTYDSLYDWLFTDSSANCYLDKVYENRYLSLLNVLKQTKDSNEIYHNSMHSLLMRIWTSMEKLQYLPAENLAFFRALIKEFYQRKLLKQDDLIFIKKLSDVFDLLMELINEEVVMSSRPSRIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGD7</accession>
    <name>C4YGD7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGD7"/>
    <dbReference type="SMR" id="C4YGD7"/>
    <dbReference type="PaxDb" id="5476-C4YGD7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03113"/>
    <dbReference type="HOGENOM" id="CLU_138100_0_0_1"/>
    <dbReference type="OrthoDB" id="4088185at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="179" mass="20761" checksum="12478565A450423B" modified="2010-10-05" version="1">MVCAHTHPPISGIFFFLLRKNCTPKLYHYFLTTNYMNGEEQVDNYDEFEINNELDFDIEEEIRKIMTLSPMSTPTSTFSPTDSISTVATEPETKANLDTISYVKSLMIDSSKLLGLYSTLKNTYLKLCKEYNYLLTKFNDNEKAKLQLIQENEELKQAMAELLQDRSSKKRRKSRKALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGK8</accession>
    <name>C4YGK8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">V-type proton ATPase subunit d</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10 11">Vacuolar proton pump subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_03187</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGK8"/>
    <dbReference type="SMR" id="C4YGK8"/>
    <dbReference type="PaxDb" id="5476-C4YGK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03187"/>
    <dbReference type="HOGENOM" id="CLU_069688_0_1_1"/>
    <dbReference type="OMA" id="REEFFRM"/>
    <dbReference type="OrthoDB" id="7676488at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016471">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3240:FF:000002">
        <property type="entry name" value="Vacuolar atp synthase subunit d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="205"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ44890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="267" mass="30020" checksum="A3FD502524A2C39C" modified="2009-07-28" version="1">MSGAGNREQVFPTRMTLGVMKSKLKGAQQGHSLLKRKSEALTKRFRDITQRIDDAKRKMGRVMQTAAFSLAEVQYATGDNISYQVQESVQKARFTVKAKQENVSGVFLPTFDSHINEDVNDFKLTALARGGQQVQKAKLIYSKAVETLVELASLQTAFIILDEVIKITNRRVNAIEHVIIPRTENTIAYINGELDEMDREEFYRLKKVQEKKQEAAAAAEQEEALAKAKAEGATDELAIQQDVEALDIKADKEEVDILQEKEDDVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGR3</accession>
    <name>C4YGR3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAWG_03245</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGR3"/>
    <dbReference type="PaxDb" id="5476-C4YGR3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03245"/>
    <dbReference type="HOGENOM" id="CLU_010365_4_0_1"/>
    <dbReference type="OMA" id="GWSYRTF"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000046">
        <property type="entry name" value="Probable ferric reductase transmembrane component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0410">Iron transport</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946762" description="FAD-binding FR-type domain-containing protein" evidence="18">
        <location>
            <begin position="19"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="19">
        <location>
            <begin position="443"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="121"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="637"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="121"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="646"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEQ44945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="738" mass="83230" checksum="E3B895A183078744" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGR9</accession>
    <name>C4YGR9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGR9"/>
    <dbReference type="PaxDb" id="5476-C4YGR9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03251"/>
    <dbReference type="HOGENOM" id="CLU_184639_0_0_1"/>
    <dbReference type="OMA" id="QHCLTIT"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="110" mass="12702" checksum="2A076DE15C3A31CF" modified="2009-07-28" version="1">MPSLTLLSSTISIGFLYTKLEQIHAIQHCLTITIICWLFFVSRSYNAVKNLGEKLALLKTNRFSRLLSLATLYIEIRKFNSIKSLLCNVFFFRNNWEQGGEANSIKFVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGT3</accession>
    <name>C4YGT3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_03265</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGT3"/>
    <dbReference type="PaxDb" id="5476-C4YGT3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03265"/>
    <dbReference type="HOGENOM" id="CLU_015718_1_0_1"/>
    <dbReference type="OMA" id="QTYSIFP"/>
    <dbReference type="OrthoDB" id="10249382at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000062">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="11">
        <location>
            <begin position="77"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="472"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ44965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="500" mass="56215" checksum="2454D465BC5D69E3" modified="2009-07-28" version="1">MPGETITLQVGQCGNQVGLQYWQQLATEHGIQSDGSSTPYPKDINDLQLQELNNSGSSPQSYPQQTKPNGKYRNDHPELFFTLSDSNTYTPRSILIDMEPSVIAKSTSALPMFNPRNVHLSNQGNGAANNWINGYKYGTEEEETLLNLIDREVDKCDNLSNFQLFHSVAGGTGSGVGSKILEVISDRYGHKKLLNTFSIFPSNEDTSDVVVQPYNTILTLKRLIDYSDATFVFHNDSLNRIENILFNNNSNIQHDDNDLFLGANKLIALVSASVSNPLRFPGYMYSSMESIVSNLIPTPDLKFLTSSIAPFSTQKHNYLNEYDMLLELSNDRYKTNRVGGDTSYISMLNYLIGNNLDQREIRKGILKSQQRISFVPWVARSVLVVHGKKSPYLKNTNLEGIQVTSNTSMIDVFTKILKQFDLLIKRKAYLNRYYSSVEEENEVMEMFNESRESVKSIIDEYKACKEITYLDDDDEDDLEDGGGGGNGNGYNNIDDADMGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH70</accession>
    <name>C4YH70_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03412"/>
    <dbReference type="HOGENOM" id="CLU_1767794_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="147" mass="17745" checksum="31BDE1070CC31C9C" modified="2010-10-05" version="1">MELLINNTNDSQTRADNISERENTQDVYSKKTIRNIKQREENSISLDIEANRIKIEEKIQKMEVKKLKALVKKEEMEHKKKIEAVKRIQKKRIKERELIKTQKNVLVEIQRIEKMIRDNNYSEEEEHEKTEELKRLYHSTMLDPVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH72</accession>
    <name>C4YH72_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_03414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YH72"/>
    <dbReference type="PaxDb" id="5476-C4YH72"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03414"/>
    <dbReference type="HOGENOM" id="CLU_1805918_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ45104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="143" mass="16262" checksum="E81AC9543F36B1EB" modified="2009-07-28" version="1">MMTMLCCTVFFTKSASTRDDGTPIGYLITNTDSYKPLASFLRFFVEKKIHIKRFIIDCSLEQVQAIKEGYNAGISNQGDHFDAAITFNPQHLFKVFNEQIKSLLKIAPSTNDTNHQSKDGELIFHKNTDSSCNRFKLTEGIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHA9</accession>
    <name>C4YHA9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gamma-glutamyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_03454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="MEROPS" id="T03.025"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03454"/>
    <dbReference type="HOGENOM" id="CLU_014813_3_1_1"/>
    <dbReference type="OMA" id="EGNMVSY"/>
    <dbReference type="OrthoDB" id="2015213at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052896">
        <property type="entry name" value="GGT-like_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
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        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881:SF1">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
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        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ45141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="586" mass="63735" checksum="F8C856CFE3F50702" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHD0</accession>
    <name>C4YHD0_CANAW</name>
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        <recommendedName>
            <fullName evidence="2">Exportin-5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_03476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="C4YHD0"/>
    <dbReference type="PaxDb" id="5476-C4YHD0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03476"/>
    <dbReference type="HOGENOM" id="CLU_003712_0_0_1"/>
    <dbReference type="OMA" id="IAKRSWG"/>
    <dbReference type="OrthoDB" id="2215036at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042565">
        <property type="term" value="C:RNA nuclear export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045478">
        <property type="entry name" value="Exportin-5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF3">
        <property type="entry name" value="EXPORTIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19273">
        <property type="entry name" value="Exportin-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exportin-5 C-terminal" evidence="2">
        <location>
            <begin position="371"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ45162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1245" mass="142505" checksum="35CD29CD8CF76121" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHK3</accession>
    <name>C4YHK3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_03550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHK3"/>
    <dbReference type="PaxDb" id="5476-C4YHK3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03550"/>
    <dbReference type="HOGENOM" id="CLU_072343_0_0_1"/>
    <dbReference type="OMA" id="YQYPAHF"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944228" description="Thioredoxin domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="50"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ45235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="332" mass="39145" checksum="8CFFD320042DD7EF" modified="2009-07-28" version="1">MQIAVLYLLLTSCMIHIYAITSSSTSSSTGDHIIEFDDNSIQPTLELADFSFIYFYSDVCKYCRKFDPTFENLSVLYNQPKQKDTIKKTGSNNERLYFQILKTNARQNNRLSQLFKVSQYPTLKLLNYKTKEIITYDNKNNRDLQSIINYLQQNLNIEPQFENFKSKVKYYQSPPSDSFKQDLDFFGNENELEKNDKLIFFIASYLPEWSDYQYPAHFIHQLALDYPDLTIIIVDYEKLNDYGVLSKYEINSFPSVMYLKNNGDYKKYQFSSQSKRELDYHKVEKFLDSVDQDNGTGEKVKESSIDTETLSHQQQEVDYEDDDDLAFEHIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHL8</accession>
    <name>C4YHL8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="4">5.3.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Isopentenyl pyrophosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Isopentenyl-diphosphate delta-isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_03566</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:23285"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="4"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHL8"/>
    <dbReference type="PaxDb" id="5476-C4YHL8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03566"/>
    <dbReference type="HOGENOM" id="CLU_060552_0_2_1"/>
    <dbReference type="OMA" id="KAPFDNG"/>
    <dbReference type="OrthoDB" id="510307at2759"/>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009240">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="NUDIX_IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000012">
        <property type="entry name" value="Isopentenyl-diphosphate Delta-isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="16">
        <location>
            <begin position="90"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00083206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ45250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="284" mass="32334" checksum="AFBFC5E053C97F58" modified="2010-10-05" version="1">MSSEYAKLVASLSNQDILTKWPEVTPLKKISGIPRSAGSDSSDSDLFDGHDEEQIRLMEELCIVLDYDDKPVGAGTKKLCHIMDNINAGLLHRAFSVFLFNEDGKLLLQQRADEKITFANMWTNTCCSHPLCVPSELGVDSSLEGSKDVNNLTNAVKGAKVAAQRKLEHELGIPFEDAPIENFTYLTRIHYKSPSGDESSKWGEHEIDYILILKTKNDITVNANYNEVKDFKYVSADELKVMFEDDSLVFTPWFKLICQSFLFKWWDNLDNLDQFKDEEIHRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHR6</accession>
    <name>C4YHR6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_03615</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHR6"/>
    <dbReference type="PaxDb" id="5476-C4YHR6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03615"/>
    <dbReference type="HOGENOM" id="CLU_002803_1_0_1"/>
    <dbReference type="OMA" id="EIDVHYF"/>
    <dbReference type="OrthoDB" id="447953at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040040">
        <property type="entry name" value="ATG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019460">
        <property type="entry name" value="Atg11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222:SF1">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10377">
        <property type="entry name" value="ATG11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="9">
        <location>
            <begin position="117"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy-related protein 11 C-terminal" evidence="10">
        <location>
            <begin position="1028"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="671"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ45298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1165" mass="135321" checksum="C31A43BCA7B313B0" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHW5</accession>
    <name>C4YHW5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochondrial distribution and morphology protein 35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_03668</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIAP1/MDM35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHW5"/>
    <dbReference type="PaxDb" id="5476-C4YHW5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03668"/>
    <dbReference type="HOGENOM" id="CLU_1495984_0_0_1"/>
    <dbReference type="OMA" id="MENECTE"/>
    <dbReference type="OrthoDB" id="19091at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990050">
        <property type="term" value="F:phosphatidic acid transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007918">
        <property type="entry name" value="MDM35_apoptosis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403:SF1">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05254">
        <property type="entry name" value="UPF0203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946780" evidence="3">
        <location>
            <begin position="21"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ45347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="180" mass="21094" checksum="DE1D86508782178F" modified="2009-07-28" version="1">MMMLLLFSDLLWFFFFPCRCVCVNFLQKRVSFLICSPPFKNCAKYGKRFHLHLPPLTIYHQKLSVVVEKKKETKIKAIPPASLKHTVIYIDMGNIMSVSFAPECTPAKNAYDDCFNKWYTEKFLKGKSMENECTEFWDTYITCINANLAKQGIKPMLDKAREDQPFDHQEIEESLNNEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHY6</accession>
    <name>C4YHY6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_03690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHY6"/>
    <dbReference type="PaxDb" id="5476-C4YHY6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03690"/>
    <dbReference type="HOGENOM" id="CLU_524767_0_0_1"/>
    <dbReference type="OMA" id="SICKWHI"/>
    <dbReference type="OrthoDB" id="2894435at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="333"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="468"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ45368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="572" mass="66419" checksum="CB67F95F8D4B7FF8" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIB9</accession>
    <name>C4YIB9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase SUV3, mitochondrial</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_04191</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIB9"/>
    <dbReference type="PaxDb" id="5476-C4YIB9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04191"/>
    <dbReference type="HOGENOM" id="CLU_010647_2_2_1"/>
    <dbReference type="OMA" id="FCEMIIF"/>
    <dbReference type="OrthoDB" id="6692397at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045025">
        <property type="term" value="C:mitochondrial degradosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17913">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18805">
        <property type="entry name" value="SF2_C_suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000269">
        <property type="entry name" value="ATP-dependent RNA helicase SUPV3L1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001549">
        <property type="entry name" value="SUV3p ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055206">
        <property type="entry name" value="DEXQc_SUV3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022192">
        <property type="entry name" value="SUV3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044774">
        <property type="entry name" value="Suv3_DEXQc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22527">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12513">
        <property type="entry name" value="SUV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="359"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ45854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="720" mass="81893" checksum="E49B016924079804" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIF2</accession>
    <name>C4YIF2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Protein URE2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_04225</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Plays an important role in the cellular response to the nitrogen source. URE2 gene plays a major part in the repression of GLN1 and GDH2 genes by glutamine, and is required for the inactivation of glutamine synthetase. URE2 gene product may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIF2"/>
    <dbReference type="PaxDb" id="5476-C4YIF2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04225"/>
    <dbReference type="HOGENOM" id="CLU_011226_14_1_1"/>
    <dbReference type="OMA" id="YEPHRID"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10293">
        <property type="entry name" value="GST_C_Ure2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000034">
        <property type="entry name" value="Transcriptional regulator URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017298">
        <property type="entry name" value="Ure2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037861">
        <property type="entry name" value="Prion_URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="8">
        <location>
            <begin position="102"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="9">
        <location>
            <begin position="195"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00058785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00074210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ45887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="344" mass="39148" checksum="90D184779636C0C1" modified="2009-07-28" version="1">MMSTDQHIQQNMNDNSNNSNNSNNNNTNNNNNNQSVNVNVNNTNNNTQTISNLSAGLKSVSLTDQQQNEVNLNLLQQQLHQEASTQQQQSRIIQFFQNQPTEGFTLFSHRSAPNGFKVAIILSELNLPFNTFFLDFNNGEQRTPEFVTINPNARVPALIDHYNDNTSIWESGAITLYLVSKYLKENGECSLWSNNLIEQSQISSWLFFQTSGHAPMIGQALHFRYFHSCPVPSAVERYTDEVRRVYGVIEMALAERREALIMDLDVENAAAYSAGTTPLSQSRFFDHPVWLVGDRTTVADLSFVPWNNVVDRIGINLKVEFPEVYKWTKHMMQRPAVKRALRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIX5</accession>
    <name>C4YIX5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar ribonucleoprotein protein MPP10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_03787</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
            <location evidence="1 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the MPP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIX5"/>
    <dbReference type="PaxDb" id="5476-C4YIX5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03787"/>
    <dbReference type="HOGENOM" id="CLU_011271_1_0_1"/>
    <dbReference type="OMA" id="HFAEDFG"/>
    <dbReference type="OrthoDB" id="445326at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012173">
        <property type="entry name" value="Mpp10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04006">
        <property type="entry name" value="Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017300">
        <property type="entry name" value="snoRNP_Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 7" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="91"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="489"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="546"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="101"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="503"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ45459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="570" mass="65437" checksum="070A73243F0017B6" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIY5</accession>
    <name>C4YIY5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">THIF-type NAD/FAD binding fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_03797</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the ATP-dependent dehydration of threonylcarbamoyladenosine at position 37 (t(6)A37) to form cyclic t(6)A37 (ct(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HesA/MoeB/ThiF family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIY5"/>
    <dbReference type="PaxDb" id="5476-C4YIY5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03797"/>
    <dbReference type="HOGENOM" id="CLU_013325_9_3_1"/>
    <dbReference type="OMA" id="GSWVVTM"/>
    <dbReference type="OrthoDB" id="10265862at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061503">
        <property type="term" value="F:tRNA threonylcarbamoyladenosine dehydratase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061504">
        <property type="term" value="P:cyclic threonylcarbamoyladenosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00755">
        <property type="entry name" value="YgdL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000125">
        <property type="entry name" value="tRNA threonylcarbamoyladenosine dehydratase 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267:SF2">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="14">
        <location>
            <begin position="56"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ45469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="434" mass="48982" checksum="D5046F60E3A0B36B" modified="2010-10-05" version="1">MSPRSIILSVVATAAVTIGLVEAFHCYERKKIHPQPPKETPAKRDHSKELIREQLARNYAFLTEDGMDKVRKQRVVVVGAGGVGSWVATMLARSGVESLRIIDFDQVSLSSLNRHAVATLKDVGIPKVECIKNHLLEIAPWIEIDTRNQLWNLESAEELIYGDDFQPTFIVDCIDNLDTKCDLLAYCHEKKLPIVSSGGAATKSDPTRINLADISKTEEDPLMKKIRVVLKKRGIINGIPVVFSAEKPDPRKAKLLPLPDDEFTKGNVDQLSALKDFRVRILPVLGTMPGMFGLAIATYILTTVAGYPMEPVEGKNRYKIYDDLLQSLAGQQTRIGKTDQRVQIAMHEVNYILEEVFRGKSPISNYSTRLTLSRWDPSKEISFQNVVVMTKDEQRNHEKRVLNGGEKIEDVYSKEVVDLVKSRFEDEKYFSQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIZ4</accession>
    <name>C4YIZ4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_03806</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="10"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIZ4"/>
    <dbReference type="PaxDb" id="5476-C4YIZ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03806"/>
    <dbReference type="HOGENOM" id="CLU_031246_0_0_1"/>
    <dbReference type="OMA" id="QCKYINA"/>
    <dbReference type="OrthoDB" id="40021at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02173">
        <property type="entry name" value="ECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="12">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Cytidyltransferase-like" evidence="12">
        <location>
            <begin position="186"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ45478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="350" mass="39382" checksum="8072B3FCD745A60B" modified="2010-10-05" version="1">MIGHAGAMLQARQLGKELYVGVHSDEEILANKGPTVMRLDERITAVEACKWTTKAIANAPYVTDPKFMDEYGCPYVVHGDDITTDANGEDCYQVVKDMGRFVVVKRTPNISTTDLVGRMLLMSKDHHYPAISRTTESLLTKDNLDRFKRYATDETGLNPGSGVYLNRGELEEIVSPKAEIGDIVYIDGGFDLFHPGHIEILKIVQQEATKLGAKVVVGIHDDAEVNQYKGLNYPIMNLLERSLCVLQCRYVDGIILGAPYVPTPEFFSKLGKSKVVKVYHGPTEIDKGVYDKIDSSVYETIGKHKYDDMNTEFIVNRVLANKQAYEERQKRKGWKAEIEKKLQQSEQSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ35</accession>
    <name>C4YJ35_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">superoxide dismutase</fullName>
            <ecNumber evidence="5">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CAWG_03847</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ35"/>
    <dbReference type="PaxDb" id="5476-C4YJ35"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03847"/>
    <dbReference type="HOGENOM" id="CLU_063073_1_1_1"/>
    <dbReference type="OMA" id="ACANITQ"/>
    <dbReference type="OrthoDB" id="159229at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000007">
        <property type="entry name" value="Cell surface Cu-only superoxide dismutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
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                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
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                <person name="Forche A."/>
                <person name="Reedy J.L."/>
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                <person name="Hube B."/>
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</entry>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="337"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="796"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="530"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ45584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="903" mass="102786" checksum="7E8CDC9BA40681D9" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJA4</accession>
    <name>C4YJA4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">cyanamide hydratase</fullName>
            <ecNumber evidence="5">4.2.1.69</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_03917</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Cyanamide hydratase involved in the detoxification and/or utilization of cyanamide, a toxic nitrile compound distributed widely in the environment.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>urea = cyanamide + H2O</text>
            <dbReference type="Rhea" id="RHEA:23056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16698"/>
            <dbReference type="EC" id="4.2.1.69"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cyanamide dehydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.69" evidence="5"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJA4"/>
    <dbReference type="PaxDb" id="5476-C4YJA4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03917"/>
    <dbReference type="HOGENOM" id="CLU_079935_0_0_1"/>
    <dbReference type="OMA" id="PWAHTTH"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018820">
        <property type="term" value="F:cyanamide hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018890">
        <property type="term" value="P:cyanamide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000027">
        <property type="entry name" value="Urea hydro-lyase/cyanamide hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017771">
        <property type="entry name" value="Cyanamide_hydratase_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03401">
        <property type="entry name" value="cyanamide_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569:SF1">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HD" evidence="8">
        <location>
            <begin position="53"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ45588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="229" mass="25989" checksum="4DA05B4D49864167" modified="2009-07-28" version="1">MSKYGFIKISRDVQQAIPNPKKPSIQLNTELPLDSPLAKFVYDYSKKRLPNETFNHSLRVYFYSVAIIKDQFADWTLDPEIVFVTSLLHDIGTSHENMHATKMSFETWGGILSRDLVLEQTKGNKDYADAVCEAIVRHQDLGESGYITTLGLILQISTILDNVGLNSHLIHEDTLDAVNKKYSRKGWLNCFAGAIDKENELKPWGHTSALGVDKFKDDVLANKLRYEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJB6</accession>
    <name>C4YJB6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_03929</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJB6"/>
    <dbReference type="PaxDb" id="5476-C4YJB6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03929"/>
    <dbReference type="HOGENOM" id="CLU_061829_0_2_1"/>
    <dbReference type="OMA" id="PTLIGHV"/>
    <dbReference type="OrthoDB" id="30840at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000108">
        <property type="entry name" value="Polyamine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051635">
        <property type="entry name" value="SNAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908:SF0">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ45600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="181" mass="20519" checksum="BEA21B7A27CCAA28" modified="2009-07-28" version="1">MTELLSNQFTRNLTIQDFDECIILESKGFPPEQRCSPENCQYRLSVASKFCLGLFETTPLGDSKLIGHILATKISTERITEAGMGKKIEGVENSGHFENSRNIGIHSVVIDPEYRGVHLGHIFLTKYIKYIRQFKLADKILIINKESLIPFYSKVGFENLGLTDCRFAGLIDYDMVYNLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJC1</accession>
    <name>C4YJC1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome c oxidase subunit 4, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome c oxidase polypeptide IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_03934</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 5B family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJC1"/>
    <dbReference type="PaxDb" id="5476-C4YJC1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03934"/>
    <dbReference type="HOGENOM" id="CLU_091071_2_0_1"/>
    <dbReference type="OMA" id="DHKPYWM"/>
    <dbReference type="OrthoDB" id="10249250at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00924">
        <property type="entry name" value="Cyt_c_Oxidase_Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.11.10:FF:000003">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.11.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002124">
        <property type="entry name" value="Cyt_c_oxidase_su5b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036972">
        <property type="entry name" value="Cyt_c_oxidase_su5b_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01215">
        <property type="entry name" value="COX5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57802">
        <property type="entry name" value="Rubredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51359">
        <property type="entry name" value="COX5B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602124-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ45605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="157" mass="17259" checksum="91691053916E158A" modified="2009-07-28" version="1">MLSRTTFRIARQQTRLLSTSRVLLGAKAAPETAVKPAKDLAEVTGAASLIGPGAKEGTIPTDYEQATGLQRLELLGKREGVDVFDMEMPISEGKGTMQDPYLVPTYIGYRYVGCKGTPEQDHKPYWMKVEEGKVSRCWQCGTVLKAKYLGEPGMAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJF1</accession>
    <name>C4YJF1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJF1"/>
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    <dbReference type="HOGENOM" id="CLU_172678_0_0_1"/>
    <dbReference type="OMA" id="SHSIVWF"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="111" mass="13106" checksum="CFE001071ACBE7ED" modified="2009-07-28" version="1">MGFPQLHLFPPFSFTLSYPFFLHIYHNHIFIQQLTQTQTQTPFPFIISSHSIVWFVNFHFFFFLGNQSSTSTINTYNPPQLLLLFLTHSQSLYFFCIYIISFISIPISISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJK6</accession>
    <name>C4YJK6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04021</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJK6"/>
    <dbReference type="PaxDb" id="5476-C4YJK6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04021"/>
    <dbReference type="HOGENOM" id="CLU_634580_0_0_1"/>
    <dbReference type="OMA" id="GRHESYP"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051140">
        <property type="entry name" value="GATA_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658:SF18">
        <property type="entry name" value="PROTEIN GAT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="6">
        <location>
            <begin position="376"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="263"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="304"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ45690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="442" mass="50093" checksum="C856B4F94C18F146" modified="2009-07-28" version="1">MNGANQNIPNTLPRLPSFQQLSETIRNPDFPDSSQKTHHQYHQQHRFQNTPIDCKSLMLFPINYTPVNDNGVATAAATATATAPVNGIVTTNSLNGNSIMEYSYGPTLHGRHESYPNQYVFPNQESKTRIPISNRVSPTSMDRTKAHSLDLELTNRVNTTNNDAKTYSKKYKVVFDLIQFLKKFEIKYNELKHYTFDLENDKNSNVLEKMVTELSIDDINEALVNTKKLANVFENIKSINENSTKSTNDMRRKNGLFVYENGNKKQQQQQQQHGEKRKIRKKHQHQMAKTKSLSTNGEAIPMQMSVSGNNSSITSTGFLQSVQQQAPQPQPQSQPQTQHQQLQPASELVPPHTQTQTLSAVTSNLTNGNLNTELSAKPEITCQHCCSQETPEWRRGPEGSRTLCNACGLFYSKLIKKYGLREADKVMLHRKQTGTVNDRRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJK8</accession>
    <name>C4YJK8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJK8"/>
    <dbReference type="PaxDb" id="5476-C4YJK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04023"/>
    <dbReference type="HOGENOM" id="CLU_010103_2_0_1"/>
    <dbReference type="OMA" id="HDIHASE"/>
    <dbReference type="OrthoDB" id="2684236at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF7">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="703" mass="79287" checksum="112B8A3589D2775A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJM3</accession>
    <name>C4YJM3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin fusion degradation protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04041</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJM3"/>
    <dbReference type="PaxDb" id="5476-C4YJM3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04041"/>
    <dbReference type="HOGENOM" id="CLU_037790_1_0_1"/>
    <dbReference type="OMA" id="VCMIETD"/>
    <dbReference type="OrthoDB" id="422728at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.50:FF:000001">
        <property type="entry name" value="Ubiquitin fusion degradation protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="5">
        <location>
            <begin position="24"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="6">
        <location>
            <begin position="125"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="254"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="311"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00074895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ45707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="363" mass="40439" checksum="ACED93FE04A0D7FE" modified="2009-07-28" version="1">MFSGFGSSIYGSGFGSSGFPSNKFEEYFRCYPIAMMPDLIRKDDANYGGKIFLPPSALNKLTMLHIRYPMLFEIKNEQNEKLTHSGVLEFIAEEGRTYLPQWMMNTLELTPGSLIKITNCDLNLGKFVKIEPQSVDFLDISDPKAVLENVLRKFSTLTVNDIIEVNYNDAIYGIRVLEVKPDSTSKGICVVETDLETDFAPPVGYVEPEYKPKTVEPSSKPIDPSKVNKSAGAATMAKSINYAKLVAEAGKTTKFSGSGQKLSGKSIDMDKNQSTKNYRIDDLDPDAPPVPLSLPENQLFFGFPVVLPTQEEIDEESKEELKKQQAFSGSGQSLRQSKKRKDKNTNYPSLKNHTRSPDAIEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJT1</accession>
    <name>C4YJT1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rgp1p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_04101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJT1"/>
    <dbReference type="PaxDb" id="5476-C4YJT1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04101"/>
    <dbReference type="HOGENOM" id="CLU_475643_0_0_1"/>
    <dbReference type="OMA" id="FMDLKYF"/>
    <dbReference type="OrthoDB" id="1918at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014848">
        <property type="entry name" value="Rgp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12507">
        <property type="entry name" value="REDUCED GROWTH PHENOTYPE 1 RGP1, YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08737">
        <property type="entry name" value="Rgp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ45765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="696" mass="79201" checksum="6EAF65A659AB83F7" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJT2</accession>
    <name>C4YJT2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJT2"/>
    <dbReference type="PaxDb" id="5476-C4YJT2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04102"/>
    <dbReference type="HOGENOM" id="CLU_438699_0_0_1"/>
    <dbReference type="OMA" id="ESIAGWT"/>
    <dbReference type="OrthoDB" id="4025103at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946706" evidence="1">
        <location>
            <begin position="20"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="557" mass="59504" checksum="C3CFC4CAB969F2F9" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJZ6</accession>
    <name>C4YJZ6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_05788</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJZ6"/>
    <dbReference type="PaxDb" id="5476-C4YJZ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05788"/>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_1"/>
    <dbReference type="OMA" id="FMTMKAA"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000081">
        <property type="entry name" value="Uncharacterized oxidoreductase MSMEG_2408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="27"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ47225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="319" mass="36395" checksum="689AEE2B26486A9B" modified="2009-07-28" version="1">MSNLTSSIQLTRQSTYKLNNGSHIPVIGFGTYLLDASQAADLTYQALKDGYRHIDTALAYHNEKEVSQGIKRFLKDHPEVQRSDIWFTTKIDTQSLGYEETKKAVERIKNDVKDNIEYVDLILIHSPLASKARRLSTYQYLQELVLNPNDAPLIVKSIGVSNYGVDHLEELFNWEGYLIKPVLNQLELHPWLPRLELREYLYKHEILAEAYSPLTQGYKLDDPELLAISKESDLTPAEILLKWSFLQGFIVLVKSDKPTRIQQNLDILPQGKKDDDELQEGVNLGVVSLNPDIIEKLNKPESHVVLTWGGKDPTLFKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKI4</accession>
    <name>C4YKI4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="2">6.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_05988</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="2"/>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKI4"/>
    <dbReference type="PaxDb" id="5476-C4YKI4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05988"/>
    <dbReference type="HOGENOM" id="CLU_014658_2_2_1"/>
    <dbReference type="OMA" id="GIVCAFD"/>
    <dbReference type="OrthoDB" id="409189at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000031">
        <property type="entry name" value="Asparagine synthase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000050">
        <property type="entry name" value="Asparagine synthetase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006949">
        <property type="entry name" value="PRK09431.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF2">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="6 10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="14">
        <location>
            <begin position="2"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="11">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="367"/>
            <end position="368"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="13">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ47413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="573" mass="64621" checksum="7AE28C4F09E74597" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKL2</accession>
    <name>C4YKL2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_06018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2072811_0_0_1"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="118" mass="13390" checksum="EA47B5B7600AA5DA" modified="2010-10-05" version="1">MAMSAISSCLHACNYKYLPLSAILSLVTVYNLFLLSESLSKQIKLTHISKPKPTQTKPSNIAPRSKSAKPVNLLFYFFVGHPPHTSFYNCAVLEFSKFTPPITSFFQNFQHKFNPQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKQ1</accession>
    <name>C4YKQ1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_06057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKQ1"/>
    <dbReference type="PaxDb" id="5476-C4YKQ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06057"/>
    <dbReference type="HOGENOM" id="CLU_010119_10_0_1"/>
    <dbReference type="OMA" id="IFLSGHT"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="2">
        <location>
            <begin position="31"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="1">
        <location>
            <begin position="235"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ47480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="47827" checksum="5C01B0C2F8A81323" modified="2009-07-28" version="1">MPVAKDKYNLRPFKEAPLSTSPIKPIELEAVDLSLYKDGAGNLPIRQKLATQIEKSLSTYGFIMVTNHGFPHDKLEFLKSLAQGILEVPLESQKPYLAGALKSDLEDRSISLGAERGAGYKPKKYWSMRNGVEDSIIHYNFNNMQHPSFFQGSGNANNNNQYPPIVQDHLSQVAEYYRYLHNDVLRKLCNLTDIVLELPEGFIWDNYYKVTPNDYENSGGGAGRFMLYEGMDPQDREKVGDTWLRGHSDSGGFTFITSQPILSLQIRDYFTGEWNYVGHTPDGLIVNIGDAMEFITGGYFKSSIHRVVGPPDDQKEFRRLVLIYFCKPKSTCILDAEPLQSPKLNRLGIGKPKEWEKIDFAAWNNEKSRLFGKKNVNDTQSEEPKLVLLYGRLHERWHQAETDFSLEEAEKKFQVIKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKW0</accession>
    <name>C4YKW0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_06119</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKW0"/>
    <dbReference type="PaxDb" id="5476-C4YKW0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06119"/>
    <dbReference type="HOGENOM" id="CLU_001103_22_0_1"/>
    <dbReference type="OMA" id="YQIMKGG"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000668">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000296">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000340">
        <property type="entry name" value="Bloom syndrome, RecQ helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013918">
        <property type="entry name" value="Nucleotide_exch_fac_Fes1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08609">
        <property type="entry name" value="Fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="480"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="682"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="14">
        <location>
            <begin position="1026"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="35"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="323"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="394"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1142"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1146"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1160"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1185"/>
            <end position="1195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ47539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1195" mass="134663" checksum="8F7A1EF29F531DA4" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKW4</accession>
    <name>C4YKW4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GTPase-activating protein GYP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Oxidant-induced cell-cycle arrest protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_06123</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the GYP5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OCA5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKW4"/>
    <dbReference type="SMR" id="C4YKW4"/>
    <dbReference type="PaxDb" id="5476-C4YKW4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06123"/>
    <dbReference type="HOGENOM" id="CLU_005350_11_3_1"/>
    <dbReference type="OMA" id="HESECFC"/>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000044">
        <property type="entry name" value="GTPase-activating protein GYP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="14">
        <location>
            <begin position="124"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="414"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ47543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="548" mass="63555" checksum="DC94717F63BAE313" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL24</accession>
    <name>C4YL24_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">5-aminolevulinate synthase</fullName>
            <ecNumber evidence="12">2.3.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">5-aminolevulinic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Delta-ALA synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Delta-aminolevulinate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_01538</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="2.3.1.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 12">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.37" evidence="12"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL24"/>
    <dbReference type="SMR" id="C4YL24"/>
    <dbReference type="PaxDb" id="5476-C4YL24"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01538"/>
    <dbReference type="HOGENOM" id="CLU_015846_6_0_1"/>
    <dbReference type="OMA" id="ARRCPIM"/>
    <dbReference type="OrthoDB" id="10263824at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003870">
        <property type="term" value="F:5-aminolevulinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000006">
        <property type="entry name" value="5-aminolevulinate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010961">
        <property type="entry name" value="4pyrrol_synth_NH2levulA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01821">
        <property type="entry name" value="5aminolev_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="13">
        <location>
            <begin position="136"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU910713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ43305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="564" mass="61395" checksum="C984334068F40487" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLI6</accession>
    <name>C4YLI6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_01704</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="C4YLI6"/>
    <dbReference type="PaxDb" id="5476-C4YLI6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01704"/>
    <dbReference type="HOGENOM" id="CLU_001042_0_1_1"/>
    <dbReference type="OMA" id="KHMDFQR"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03275">
        <property type="entry name" value="ABC_SMC1_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028468">
        <property type="entry name" value="Smc1_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="12">
        <location>
            <begin position="526"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="174"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="404"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="832"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1024"/>
            <end position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ43467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1240" mass="141711" checksum="7BC2B14EF7EE9AE6" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLL7</accession>
    <name>C4YLL7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_01736</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLL7"/>
    <dbReference type="PaxDb" id="5476-C4YLL7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01736"/>
    <dbReference type="HOGENOM" id="CLU_016743_3_0_1"/>
    <dbReference type="OMA" id="IRTQMCW"/>
    <dbReference type="OrthoDB" id="10250549at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04652">
        <property type="entry name" value="LbH_eIF2B_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="11">
        <location>
            <begin position="7"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="EIF2B subunit epsilon/gamma LbH" evidence="12">
        <location>
            <begin position="331"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="319"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="438"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="438"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ43498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="480" mass="54320" checksum="2E2EB1719E35BAF9" modified="2009-07-28" version="1">MEFTAVIVCGKGKALTPFSQVRSTGIPKPLLPIANKPMVQYVLDWCLQANFSRIIVLFEKEDESSGVLEQTIKRYQEEKEKTNTNKNESHVSIDVIPYNCENNGLILYKLYELYSENKVSNNNFIILPCDLITNLPPQVIIEAYRNKNDSDLGLVIAYKNQLDIEDKKAKIFPQSYTIYSDTDENGNESPVFLDTYSQADIEFHQALSIRTQMCWRYPAATVSNKLLNSGIFLGSCSQIFSVFDEQKDKFTESYFEKRSLMKIVRDLARRSWKHALHQASVGFFIVPKQATFFRCNNLPVLMEANRYFMKKQAIAKSASQNTQAPSKQDKQSGAHVGNDSLVGENTELGEKTNVKRSVIGSNCKIGKKNKITGCLILDNVEIHDDVTLENCIIGHDVIIQSKCKLTNCNVESTNEVAHNTQAKNSNLLCLTLEGLVNEDDQYGDDSDDEEDSEEYDSTDDEDESEFEDEYTGNEDGLFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLM2</accession>
    <name>C4YLM2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit</fullName>
            <ecNumber evidence="5">2.4.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GlcNAc-PI synthesis protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_01741</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.198" evidence="5"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="SMR" id="C4YLM2"/>
    <dbReference type="PaxDb" id="5476-C4YLM2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01741"/>
    <dbReference type="HOGENOM" id="CLU_009583_19_0_1"/>
    <dbReference type="OMA" id="SHFWMSG"/>
    <dbReference type="OrthoDB" id="734129at2759"/>
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    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
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        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03796">
        <property type="entry name" value="GT4_PIG-A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000053">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000026">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039507">
        <property type="entry name" value="PIG-A/GPI3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="14">
        <location>
            <begin position="42"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="13">
        <location>
            <begin position="190"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006122"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012420"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ43503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="452" mass="50973" checksum="420D6A8416740BCC" modified="2010-10-05" version="1">MGYNIAMVTDFFYPQPGGVEFHVYHLSQKLIELGHSVVIITHNYSSRNGVRVLTNGLKVYYVPLWVIYRSSVFPTVFSCFPILRNIFIRENIEIIHGHGSFSTLCHEAILHGRTMGLKTVFTDHSLFGFAEIGSIMGNKALKFTFSDVGHVICVSHTCKENTVLRGSIDPIKVSVIPNAVISKDFKPKSHCVNKNYTKEITIVVITRLFPNKGADLLTAVIPKICQLKPKVKFLIAGDGPKFLDLEQMREKYFLQERVTLVGAIKHEEVRDVMVQGDIYLHPSLTEAFGTVIVEAASCGLYVVTTKVGGIPEVLPNEMTSFAEPEENSLIDAAIDAINKIESNEIDTSKFHDAVAKMYSWNDIARRTENVYNSLDLDKLNESLLHRLQRYYCCGIIAGKLYALCVIVDIFIFVILEWLYPADHIDKATKWPSAIKEEDESEEETFIFPNKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLZ0</accession>
    <name>C4YLZ0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLZ0"/>
    <dbReference type="PaxDb" id="5476-C4YLZ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01863"/>
    <dbReference type="HOGENOM" id="CLU_524766_0_0_1"/>
    <dbReference type="OMA" id="EHEHEEY"/>
    <dbReference type="OrthoDB" id="4022920at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="519" mass="58963" checksum="E939D640F56DDA04" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM98</accession>
    <name>C4YM98_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcriptional regulatory protein SDS3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_01977</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM98"/>
    <dbReference type="SMR" id="C4YM98"/>
    <dbReference type="PaxDb" id="5476-C4YM98"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01977"/>
    <dbReference type="HOGENOM" id="CLU_067595_0_0_1"/>
    <dbReference type="OMA" id="VANAHSY"/>
    <dbReference type="OrthoDB" id="70376at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21964">
        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="233"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="98"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="233"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38470" checksum="EF742C629DDCB7E3" modified="2009-07-28" version="1">MEESRKNGTIHETQPPQNKRDKKRTNIAGRLNKLELTFKNDRDMFYRNSLHELQNKLATLQQGSNEEFLYKKMNLEEVRDYELTKLRLWEEYQVKRIESEYQEDLNRAKEQHDKMIKLIKEKLYDKLQQQIKHLKEDKFLVNLVNGKSWMNPEDPTNQAFNSVAIAELNANDRRSLRKRELAGRFSVGEAADLSDGGGGSGVGGGSADNFSSVYNNGGYSSAGKRRRIYATRYSSNDELSSGTTSGMPLNNHSSTRQNGNATSGYESNLSDKDYDTLNVLIMENEDGGASLNLTAKNGGVSQHKVQTRGSNKHFVGPQGLKPEELNEDLTLLRNAIVKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMA2</accession>
    <name>C4YMA2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_01981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMA2"/>
    <dbReference type="PaxDb" id="5476-C4YMA2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01981"/>
    <dbReference type="HOGENOM" id="CLU_130042_1_0_1"/>
    <dbReference type="OMA" id="RYGRVWP"/>
    <dbReference type="OrthoDB" id="5554402at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019419">
        <property type="entry name" value="AIM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28177">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 19, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28177:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 19, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10315">
        <property type="entry name" value="Aim19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="174" mass="18467" checksum="ACD8EA7DEB2FCAED" modified="2010-10-05" version="1">MAINFSSISIKPTWTYHNYPPINKMAQPQTNSIYDSIDKLSVSPIPAAALGGSLVLKGLFGTNATPVNVGATGGTGSAFKLGRKVAVARPTRLSCFTFGGASLLGAWMMYDGDPVNASGFNFAWSALYLIVNGKESISGIFKGRITPLGLGGLALFNTGLYGREFFWSKNSPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMB9</accession>
    <name>C4YMB9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C-1-tetrahydrofolate synthase, cytoplasmic</fullName>
            <ecNumber evidence="8">1.5.1.5</ecNumber>
            <ecNumber evidence="7">3.5.4.9</ecNumber>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">CAWG_01998</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:23701"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:23702"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:22813"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:22814"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>(6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:20222"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:20223"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="8"/>
    <dbReference type="EC" id="3.5.4.9" evidence="7"/>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMB9"/>
    <dbReference type="PaxDb" id="5476-C4YMB9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01998"/>
    <dbReference type="HOGENOM" id="CLU_003601_2_0_1"/>
    <dbReference type="OMA" id="QPIMFRR"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009257">
        <property type="term" value="P:10-formyltetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000006">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000245">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001123">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.770:FF:000001">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00766">
        <property type="entry name" value="THF_DHG_CYH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="17" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="23">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="24">
        <location>
            <begin position="143"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00017592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00051544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00052163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EEQ43750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="946" mass="102149" checksum="A533FEB7637E60B3" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMG9</accession>
    <name>C4YMG9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMG9"/>
    <dbReference type="PaxDb" id="5476-C4YMG9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02049"/>
    <dbReference type="HOGENOM" id="CLU_009505_1_0_1"/>
    <dbReference type="OMA" id="LMSIYDP"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF7">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="115"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ43800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="860" mass="97615" checksum="00BD3A4771BEC895" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMH7</accession>
    <name>C4YMH7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_02059</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMH7"/>
    <dbReference type="SMR" id="C4YMH7"/>
    <dbReference type="PaxDb" id="5476-C4YMH7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02059"/>
    <dbReference type="HOGENOM" id="CLU_130128_3_0_1"/>
    <dbReference type="OMA" id="CASILCQ"/>
    <dbReference type="OrthoDB" id="5567124at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.100:FF:000001">
        <property type="entry name" value="40S ribosomal protein S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_eS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_eS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_eS27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11594">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01168">
        <property type="entry name" value="RIBOSOMAL_S27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ43808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="82" mass="8969" checksum="8C8400168222D769" modified="2009-07-28" version="1">MVLVQDLLHPSPATEAKQHKLKTLVQQPRSFFMDVKCQGCLNITTVFSHAQTAVTCDSCSTVLCTPTGGKAKLTEGCSFRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMJ0</accession>
    <name>C4YMJ0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMJ0"/>
    <dbReference type="PaxDb" id="5476-C4YMJ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02072"/>
    <dbReference type="HOGENOM" id="CLU_021251_0_0_1"/>
    <dbReference type="OMA" id="FKGGSTC"/>
    <dbReference type="OrthoDB" id="416093at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF589">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE [ACETYL-TRANSFERRING]]-PHOSPHATASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="57"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="433" mass="48663" checksum="0982ADA0DBBFBBBB" modified="2009-07-28" version="1">MSTRSRQLLPPSLSFVRHVSQTVTFTAMDISSSGGFSHKQPSKVGKLIVPILKSPSHLGHSTSRVNRLYNEDKYSANLLQVKESQIFNFSIFDGHGGDQCSTYLAENLSSALEDSDQLVDNDNDRQELFKKYAKNVGGYWKRWYKHRDNTVANWEKERIKLKNFLSDDLATRVPLAFLNADYNFFSKEQKSGSTCTSALIETIYSKPGTFQPFFENYYFNRHTISKLSIGHLGDTRAIVADKNGLAHTLTTDHHPSNPIEAKRLRKYAANFFMTDSFGEERFVALANTRAFGDVDYKEVGVTAEPDFNQYIIGDSDAIKQFLTPDEIEKYTIGGLGGDESFLILCSDGVTNILTDQEIADIVLTHVNLKGQTVATPQYCAEQVIKFVEFVGGDDNATCLVIRLNGWGNWPIIDRTGELRQARLDDYNPRGARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMJ1</accession>
    <name>C4YMJ1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alcohol dehydrogenase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMJ1"/>
    <dbReference type="PaxDb" id="5476-C4YMJ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02073"/>
    <dbReference type="HOGENOM" id="CLU_020748_0_0_1"/>
    <dbReference type="OMA" id="QFHYTTI"/>
    <dbReference type="OrthoDB" id="201656at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052585">
        <property type="entry name" value="Lipid_raft_assoc_Zn_ADH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482">
        <property type="entry name" value="PROTEIN AST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482:SF1">
        <property type="entry name" value="PROTEIN AST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="2">
        <location>
            <begin position="144"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ43822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="613" mass="69823" checksum="76C3B1EFA5CAA2E2" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMK2</accession>
    <name>C4YMK2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMK2"/>
    <dbReference type="PaxDb" id="5476-C4YMK2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02084"/>
    <dbReference type="HOGENOM" id="CLU_2158027_0_0_1"/>
    <dbReference type="OMA" id="SPCICIF"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="111" mass="12753" checksum="CBD7EAB3EBD313B7" modified="2009-07-28" version="1">MAYLPQCTVVVFPVTSVSVFKFTVSIFILKYMHAYFQIVFIAAVYCLFFFLSPCICIFVPSALDAYCLSLAACSCLVLDVLCITYTPQTIISFFFLQPSSKIYLFEYFRYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMK5</accession>
    <name>C4YMK5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_02087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMK5"/>
    <dbReference type="PaxDb" id="5476-C4YMK5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02087"/>
    <dbReference type="HOGENOM" id="CLU_2512401_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="85" mass="9320" checksum="05DAE64A8D487FBE" modified="2009-07-28" version="1">MTKVLNGFSLSTLSLVNIIPPHKLETSISGGKPYVNAGYILQTLQLQTLNLSFLCANCLWQISVEASKLTQNKDLELDTVQSVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMP2</accession>
    <name>C4YMP2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Outer spore wall protein RRT8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMP2"/>
    <dbReference type="PaxDb" id="5476-C4YMP2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02126"/>
    <dbReference type="HOGENOM" id="CLU_062645_3_0_1"/>
    <dbReference type="OMA" id="GRYFQLK"/>
    <dbReference type="OrthoDB" id="10012223at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005619">
        <property type="term" value="C:ascospore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF2">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27779" checksum="3E8758C263ECBCB9" modified="2010-10-05" version="1">MFSLFFPPQAIVYTLLMGPLGVIGAWYSLISQASTLSIFVVTISLMPHIQRVAYDAILSRECANDVVLMGKLRRYRKLPIRVRAREYLKAIPDFSIFPFSLLKLLVFFGIYFIPFVGPIIVLFFQSSKRGLKAHARYFKLKGFSRSDIRTIHKLNRPAYMGYGVVALWLESFPFINMFFMFTNTLGAALWAVDIEQQEKAVTENVAAATTTATDTNSVNQQGLVIPVHNEPATNIPEATPKTATNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMS0</accession>
    <name>C4YMS0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3,2-trans-enoyl-CoA isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_02154</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMS0"/>
    <dbReference type="PaxDb" id="5476-C4YMS0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02154"/>
    <dbReference type="HOGENOM" id="CLU_009834_6_2_1"/>
    <dbReference type="OMA" id="CTPETYL"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000048">
        <property type="entry name" value="3,2-trans-enoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ43901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="29261" checksum="728D2BA075993AA3" modified="2009-07-28" version="1">MSDPITYEVKDRAVLITLNNPKKLNSLTIPQYGILCKFLERANNEEGTIITLIQSTGRVFSAGANADFVTSQDTELDTWLNLSVAKQTFLVQTFLAHKKILAVALNGPAIGLSASFVTLCDLVYVNDLSKTFFLTPFANIGILAEGGTSATLPIRLGWSKAAEALLLSKRISGQDLQNAGLVNKHYGGKFKTAEEFNSTVLGELLDATENLHVDSILQNKELLKQIYKPAISMVNSQEVSRGVYKWTSGIPKDRFKKLASGELKHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN37</accession>
    <name>C4YN37_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparaginase</fullName>
            <ecNumber evidence="2">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_02277</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-asparagine + H2O = L-aspartate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="EC" id="3.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the asparaginase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN37"/>
    <dbReference type="SMR" id="C4YN37"/>
    <dbReference type="PaxDb" id="5476-C4YN37"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02277"/>
    <dbReference type="HOGENOM" id="CLU_019134_0_0_1"/>
    <dbReference type="OMA" id="RYYMQPL"/>
    <dbReference type="OrthoDB" id="542841at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006530">
        <property type="term" value="P:L-asparagine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08964">
        <property type="entry name" value="L-asparaginase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1170:FF:000001">
        <property type="entry name" value="L-asparaginase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.40:FF:000006">
        <property type="entry name" value="L-asparaginase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004550">
        <property type="entry name" value="AsnASE_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020827">
        <property type="entry name" value="Asparaginase/glutaminase_AS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00520">
        <property type="entry name" value="asnASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00144">
        <property type="entry name" value="ASN_GLN_ASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="10">
        <location>
            <begin position="126"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="11">
        <location>
            <begin position="351"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="active site" description="O-isoaspartyl threonine intermediate" evidence="5">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="211"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ44018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="484" mass="52658" checksum="738659EFB068FE36" modified="2010-10-05" version="1">MTPPKRRESSSSITNILTLNNLELGATAGEVRGAGAISEENGLVHHQHHLEDSEHYHTTQVEIESHFSTDDEINHPGNNFNDDQISHLPTIKIKYHRSNSVHSISSANSFDGANNISGDISLLPTIKVLGTGGTIASKGVSSHQTAGYEVDLTIEDLVSTIPDLSQTCQLEYEQVLNIDSKEMDNSSLLKLYHKIQLDLPHYDGIVITHGTDTMEETAFFLQSTINTFKPIVLCGSMRPSTAISSDGPMNLYQAIAIASNRESRGRGVLIALNDRIGSGFYITKSNANSLDTFKSIGQGYVGNFVNNEIRYFFPPAKPLGLTMFHINDLFSSSSSSSAIGGNDIIPCLPEVTIIYAHQGLNNEIFKFVINDLKSKGIILATMGAGSMSDKTNQYLSDLLINNPNYPIVYSKRSMDGMVPIGSLPKVLAVIKDAADNGKPATKKVPFVNAIAGGYLNPQKARILLQLCLNEGMDLSKIKNVFKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN86</accession>
    <name>C4YN86_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pop3p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN86"/>
    <dbReference type="PaxDb" id="5476-C4YN86"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02326"/>
    <dbReference type="HOGENOM" id="CLU_047273_0_0_1"/>
    <dbReference type="OMA" id="QWPFIEP"/>
    <dbReference type="OrthoDB" id="20109at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013241">
        <property type="entry name" value="RNase_P_Pop3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28272">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28272:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08228">
        <property type="entry name" value="RNase_P_pop3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24636" checksum="A49ABBCC23BD0D0A" modified="2009-07-28" version="1">MNKSNKVKKPSVAKVSTKAASSSLKSQEAKRKQVFRPILDNSFTQSNQWPFIEPTIANDIVDLLEVLLKMQDSTFKYRGFNPTVSALEKQAAANRGIHKNACVQIKYVFVCKYDISPATLTNVFPTLCFTASKSAEDRVKLIQLPRGSLERLSKALGVDRVGIFGLTKDTEGAQPLFDLINENVKDIEAPWLDCIFREEMVFNQPNTKHVASTVGRKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNN2</accession>
    <name>C4YNN2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_01495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIGH family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNN2"/>
    <dbReference type="PaxDb" id="5476-C4YNN2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01495"/>
    <dbReference type="HOGENOM" id="CLU_1337344_0_0_1"/>
    <dbReference type="OMA" id="ANNDKNP"/>
    <dbReference type="OrthoDB" id="6256716at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044215">
        <property type="entry name" value="PIG-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019328">
        <property type="entry name" value="PIGH-H_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10181">
        <property type="entry name" value="PIG-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved" evidence="4">
        <location>
            <begin position="97"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ43265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="205" mass="23494" checksum="62380DB8F9509ECA" modified="2009-07-28" version="1">MSSSKNYKLEISPSINQTSATESQNLLKFTVRNDRPSKIITYRLPIIVLLASLTVANIIQNIEQVKNYDIDASHHGILLILVVGIVLLLCLQTPEDTLIVMRGIGIQLQSKKMWRFQSSDSFIPINNMIDLVIHEGFHDYGQVIFYLCVLTKANNDKNPITIVFPEFLPRKDILLTVWRLSRELLFGSTKRYWRRVPGQGLKQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNP7</accession>
    <name>C4YNP7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase DBP10</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-dependent RNA helicase dbp10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CAWG_02828</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNP7"/>
    <dbReference type="SMR" id="C4YNP7"/>
    <dbReference type="PaxDb" id="5476-C4YNP7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02828"/>
    <dbReference type="HOGENOM" id="CLU_003041_5_1_1"/>
    <dbReference type="OMA" id="EDQFGMM"/>
    <dbReference type="OrthoDB" id="10261375at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17959">
        <property type="entry name" value="DEADc_DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000865">
        <property type="entry name" value="ATP-dependent RNA helicase DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033517">
        <property type="entry name" value="DDX54/DBP10_DEAD-box_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0347">Helicase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="130"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="373"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="352"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="821"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="844"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EEQ44556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="908" mass="103561" checksum="CA20D4A7D93C712C" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNZ5</accession>
    <name>C4YNZ5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="4">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Thiol-specific antioxidant protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAWG_02929</name>
        <name evidence="20" type="ORF">CAWG_02945</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 21">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Also involved in the correct composition of the hyphal cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="4"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNZ5"/>
    <dbReference type="SMR" id="C4YNZ5"/>
    <dbReference type="PaxDb" id="5476-C4YNZ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02929"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02945"/>
    <dbReference type="HOGENOM" id="CLU_042529_21_1_1"/>
    <dbReference type="OMA" id="FWYPKDF"/>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF171">
        <property type="entry name" value="PEROXIREDOXIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 14" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9 14" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="18">
        <location>
            <begin position="3"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="15">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00082674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEQ44654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEQ44669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="196" mass="21860" checksum="0BD7B6B4715DCDBB" modified="2009-07-28" version="1">MAPVVQQPAPSFKKTAVVDGVFEEVTLEQYKGKWVLLAFIPLAFTFVCPSEIIAYSEAVKKFAEKDAQVLFASTDSEYTWLAWTNVARKDGGIGKVDFPVLADTNHSLSRDYGVLIEEEGVALRGIFLIDPKGVLRQITINDLPVGRSVEESLRLLEAFQFTEKYGEVCPANWHPGDETIKPSPEASKEYFNKVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP47</accession>
    <name>C4YP47_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATPase expression protein 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_02985</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for translation of the mitochondrial OLI1 transcript coding for the mitochondrial ATP synthase subunit 9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to the 5'UTR of the OLI1 mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AEP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YP47"/>
    <dbReference type="PaxDb" id="5476-C4YP47"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02985"/>
    <dbReference type="HOGENOM" id="CLU_493556_0_0_1"/>
    <dbReference type="OMA" id="KWFQRFE"/>
    <dbReference type="OrthoDB" id="4077974at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024319">
        <property type="entry name" value="ATPase_expression_mit"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12921">
        <property type="entry name" value="ATP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ44706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="654" mass="76649" checksum="51FC75A614BE1996" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP60</accession>
    <name>C4YP60_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphomutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_03002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YP60"/>
    <dbReference type="PaxDb" id="5476-C4YP60"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03002"/>
    <dbReference type="HOGENOM" id="CLU_039184_0_0_1"/>
    <dbReference type="OMA" id="NWVDARL"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ44719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="37297" checksum="5660060A620963FD" modified="2009-07-28" version="1">MSKNIPNQADVVDAKISDTDRQQYEELLLKYYEENNTNPHWEFSIVPGIFKQSLPETDATKFDTIKEHFGVICGWDEVIAQLNELNSQVDSNEIQYKLFFLARHGQGFHNVKHNENPQLWDDYWSHLNTDGKIVWGPDPELTELGIEQAKDNNVAWTKEIENNINKNKNLIIPTKFFTSPFRRSVDTLINTWDNIIDLKEIKPLIQEYWRETIGDHTCDKRSTRSIIAEKYESLGFIIEPGFEEEDIYWKPDWRESVAEQAIRQNKGLQELFNENHKDQIVSITSHSGSIRTQLLVLGHRPFAIGTGGMIPVFVKGVKVAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPH1</accession>
    <name>C4YPH1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_02370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPH1"/>
    <dbReference type="PaxDb" id="5476-C4YPH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02370"/>
    <dbReference type="HOGENOM" id="CLU_052998_1_1_1"/>
    <dbReference type="OMA" id="RHGASQM"/>
    <dbReference type="OrthoDB" id="419694at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.170.30:FF:000002">
        <property type="entry name" value="Phosphotransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.970:FF:000002">
        <property type="entry name" value="Tpt1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ44110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="207" mass="23638" checksum="2C996FAB0D34C01C" modified="2009-07-28" version="1">MPPPDKARRDVLISKALSYLLRHGAEKEKLSIDDQGYVKISDVLSHQRLKSLKTTRDDINRIVQENDKKRFTIKDDMICANQGHSLKAVKNDNLTPMTVDELSQLRIYHGTYRTKLPLIKSSGGLSKMNRNHIHFTCDQYSTCSGIRYNANVLIYINASKCIEHGIVFYKSLNNVILTSGDKDGKLSWEFIDRIVDLDGNEINKEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPN2</accession>
    <name>C4YPN2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH dehydrogenase (Ubiquinone) complex I, assembly factor 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_02433</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NDUFAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPN2"/>
    <dbReference type="PaxDb" id="5476-C4YPN2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02433"/>
    <dbReference type="HOGENOM" id="CLU_037269_6_3_1"/>
    <dbReference type="OMA" id="MINAREQ"/>
    <dbReference type="OrthoDB" id="270318at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000068">
        <property type="entry name" value="Conserved hypthetical protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181:SF13">
        <property type="entry name" value="NADH DEHYDROGENASE (UBIQUINONE) COMPLEX I, ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ44171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="43556" checksum="48E7F549673BEB05" modified="2009-07-28" version="1">MITRSRHISKRLYSTNYSAILFNAQENVNQLLESQDRSSYILAQYIPEPVRNTYLAIRAFNLEINKINESGSNVQSRAARASSQMSNTLGVSTADLKFKFWSDLILRVFTEDSRNETDLGEPIAILLRDGLKHDFNLDISYFQQFLQTRRHFIKNNSSFQTVNDICSYGEGTFSQLNYLTQGLLLSPSISPSVIRLLEYSTELQSQMSDIAAHIGQATAVSSMILGVPFYAQSRNQITLPVDLMTSSGLSQESLLRLFQGHIKDSAEENQIKEALKNVVYETAITANDHMLTAKSKLEMARQEIKKIVQEQPQDQLLNKFSKKWRKGIPDSLYVPTMAGIPTSLFLNKLEKCNFDLFHGRLQKEWRLPMKSFYYYHMRLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQI8</accession>
    <name>C4YQI8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_02746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQI8"/>
    <dbReference type="PaxDb" id="5476-C4YQI8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02746"/>
    <dbReference type="HOGENOM" id="CLU_043167_0_0_1"/>
    <dbReference type="OMA" id="THRTAMT"/>
    <dbReference type="OrthoDB" id="2150604at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ44477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="40022" checksum="4424C8350F12C6D0" modified="2009-07-28" version="1">MTLDNSIVYSRPLSVSENFFRCRTASGNYRNFVVTATYNQSLKKKLYVLVKALRKTILEYPILATTVKFDKTVNAFAYVPLKTINLSDILFFEGDEKWLTNGVINENYMKYCNETQFKLYEENVLFKLILVGDFHLSAIFEHTIGDGLVANYFHEVLLKNLAECESIEDAAFETQFGPLVFENIKAEDEIFNFSKDKLYIKNSLPPPIDPFLEDIDLDYSFGDPHFQDKIIPEGFPNKWKGRFDTVDTHDISFKLINFSKQETKIILSKCKEHKVGITSYIEVVHALTLQPIFGDNSFTTHRTAMTLRRHYTPDLAEPPYKKILSDSEYKIFGTSAHMGFVRIFHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQJ1</accession>
    <name>C4YQJ1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQJ1"/>
    <dbReference type="PaxDb" id="5476-C4YQJ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02749"/>
    <dbReference type="HOGENOM" id="CLU_008472_0_0_1"/>
    <dbReference type="OMA" id="CHVNARE"/>
    <dbReference type="OrthoDB" id="160374at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052609">
        <property type="entry name" value="Ribosome_Biogenesis_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018849">
        <property type="entry name" value="Urb2/Npa2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682:SF2">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10441">
        <property type="entry name" value="Urb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal" evidence="1">
        <location>
            <begin position="915"/>
            <end position="1120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1120" mass="128974" checksum="EAF6CC5CDEBFF2E5" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQR1</accession>
    <name>C4YQR1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL14m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04408</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQR1"/>
    <dbReference type="SMR" id="C4YQR1"/>
    <dbReference type="PaxDb" id="5476-C4YQR1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04408"/>
    <dbReference type="HOGENOM" id="CLU_095071_2_0_1"/>
    <dbReference type="OMA" id="IVCVVQK"/>
    <dbReference type="OrthoDB" id="274765at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000005">
        <property type="entry name" value="50S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_uL14_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ46064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="132" mass="14672" checksum="7D67A0C4F5F451A9" modified="2010-10-05" version="1">MIYLKSLLNVIDNSGAQVVECIKVLRHKPKSCAQIGDRITCVVKQARPLQQELTGQSSTNRVKRRDICQAVVVRTRAPLKRKDGSVVRFDDNACVLINKNGEPLGTRISSVVAKELKDLNYNKIVALAPKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQU4</accession>
    <name>C4YQU4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_04441</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQU4"/>
    <dbReference type="PaxDb" id="5476-C4YQU4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04441"/>
    <dbReference type="HOGENOM" id="CLU_010811_4_3_1"/>
    <dbReference type="OMA" id="GYIGWIS"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="200"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="84"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ46097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="618" mass="71093" checksum="65C381897311179D" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQV3</accession>
    <name>C4YQV3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_04450</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQV3"/>
    <dbReference type="SMR" id="C4YQV3"/>
    <dbReference type="PaxDb" id="5476-C4YQV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04450"/>
    <dbReference type="HOGENOM" id="CLU_030988_13_2_1"/>
    <dbReference type="OMA" id="AEPHEDN"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23813">
        <property type="entry name" value="UBCc_UBE2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000020">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ46106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="169" mass="19057" checksum="5F1E64148F5FC048" modified="2010-10-05" version="1">MAALPKRIIKETERLVSDPVPGIIATPSEDNLRYFEVTIIGPNQSPYAKGKFKLELYLPDDYPMCAPKVRFLTKIYHPNIDKLGRICLDVLKDNWSPALQIRTILLSIQALLGAPNPDDPLANDVAQDWKSDEKKAIEVAKEWTAKYAIDETEKANDDKDESTTKESTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQV5</accession>
    <name>C4YQV5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_04452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQV5"/>
    <dbReference type="PaxDb" id="5476-C4YQV5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04452"/>
    <dbReference type="HOGENOM" id="CLU_016174_1_1_1"/>
    <dbReference type="OMA" id="REVMICT"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="694" mass="80357" checksum="FAC97C18909166D9" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQX0</accession>
    <name>C4YQX0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ctf8p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04467</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CTF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQX0"/>
    <dbReference type="SMR" id="C4YQX0"/>
    <dbReference type="PaxDb" id="5476-C4YQX0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04467"/>
    <dbReference type="HOGENOM" id="CLU_090690_1_0_1"/>
    <dbReference type="OMA" id="QRPLPIM"/>
    <dbReference type="OrthoDB" id="121932at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018607">
        <property type="entry name" value="Ctf8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605:SF1">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605">
        <property type="entry name" value="CTF8, CHROMOSOME TRANSMISSION FIDELITY FACTOR 8 HOMOLOG (S. CEREVISIAE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09696">
        <property type="entry name" value="Ctf8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ46123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="18400" checksum="200BB815CE6BC300" modified="2010-10-05" version="1">MPTATIDCSSAQDILNNPSTNDNDLIFTPYGLMLLEIQGELNLPNEFPQGQPKTDEDHEYLNNFITINEIQHAVKFGNLVFDEKDNSKVTLYIGKSQRLLGNVVKLSTPLAVLRIPLKNEDEMMVDSNNDNVNKFKQEEELIKLVDIVKAKVIFKQRPLPIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR03</accession>
    <name>C4YR03_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR03"/>
    <dbReference type="PaxDb" id="5476-C4YR03"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04500"/>
    <dbReference type="HOGENOM" id="CLU_034963_2_0_1"/>
    <dbReference type="OMA" id="YELGAHY"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22762">
        <property type="entry name" value="OTU_fungi_OTU2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.80:FF:000022">
        <property type="entry name" value="OTU2p protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049771">
        <property type="entry name" value="OTU2-like_OTU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF10">
        <property type="entry name" value="DEUBIQUITINASE OTUD6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="177"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="323" mass="36820" checksum="47413097752D20D9" modified="2009-07-28" version="1">MSENEQQPTVTTREELLQRHKKESKDLIATITGLKKQATKKTRKSVLNKCQELQDNLDQKHKQELKEFDNPNGGQDEDEEVMPEQLLAQLSLEKESPVAEISNTESLEEGINSGSGGNADDSSKPRKKRNRQRERLNRRQAEIDKIKQEAAIEASNTVDYRQIEIESMDKLLSLNNLQSFEIKPDGHCLFASIQDQLKVRHQDVEHLDHNGPEDVPSIDQLRKLAGDYIKSNQEDFIPFLIDENTGELRDLDDYINELTTTAMWGSDMEILALSKVFNCPISIYMAGASTLTINEHGQLPELKLGYYKHSFGLGEHYNSLRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRL4</accession>
    <name>C4YRL4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Centractin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Actin-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Actin-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_04714</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the actin family. ARP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRL4"/>
    <dbReference type="SMR" id="C4YRL4"/>
    <dbReference type="PaxDb" id="5476-C4YRL4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04714"/>
    <dbReference type="HOGENOM" id="CLU_027965_0_2_1"/>
    <dbReference type="OMA" id="YTTWTGG"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10216">
        <property type="entry name" value="ASKHA_NBD_Arp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000007">
        <property type="entry name" value="Actin like 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000018">
        <property type="entry name" value="Actin-like protein (Centractin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00076361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00083222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ46367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="414" mass="46742" checksum="EC83D0A87161BB54" modified="2010-10-05" version="1">MAEILYNQPVVIDNGSGNLKAGFAGEDKPKSYASAIIGRPKYQKIMAAGSTSLLSEQQSHDQLFIGNSAQDNRGLLKLSYPIEHGIVNNWSDMEKLWYHTYTQDLKTQSEDHPLLITEAPLNPRSNRNKMCQILFENFNIPCIYISIQAVLSLYASGRTTGVVIDSGDGVTHVVPVYEGFALPPSIKRMDIAGRDITESLAFNIRRMTGVALQSSSELEIVRLIKEQNCFISKDPVRDEKKYGSHYSRNNPNNELMSTYKLPDGHEIQLGVERFRATEILFNPQLIGHESPGIHELTSLAIAKTDLDLRSTLYQNIILSGGNTLLKNFGDRMLKELKDLQQPLQEDQKMSIWNKNVQNDVYNTKMKVKIYAPPERKYSTWIGGSILAGLSTFKKMWVTSEEYHENPDIVHVKCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRP8</accession>
    <name>C4YRP8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_04751</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRP8"/>
    <dbReference type="PaxDb" id="5476-C4YRP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04751"/>
    <dbReference type="HOGENOM" id="CLU_001715_0_1_1"/>
    <dbReference type="OMA" id="NFITHEV"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000002">
        <property type="entry name" value="Guanylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000776">
        <property type="entry name" value="Guanylate kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="9">
        <location>
            <begin position="6"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ46401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="190" mass="21267" checksum="B459A8B202D5E675" modified="2009-07-28" version="1">MSSSANRPIVISGPSGTGKSTLLKKLFAEYPDKFGFSVSNTTRKPRPGEVNGKDYNFSTVEEFKQLIDENKFIEWAQFSGNYYGTTIKAVKDVAEQGRICLLDIDMQGVKSVKKTDLNARYLFISPPSIEELKSRLTGRGTETEDSLQKRIAAASDEMEYAQTGAHDKIIVNDDLDKAYAEFKKFIVDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRU0</accession>
    <name>C4YRU0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_04797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRU0"/>
    <dbReference type="PaxDb" id="5476-C4YRU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04797"/>
    <dbReference type="HOGENOM" id="CLU_2263363_0_0_1"/>
    <dbReference type="OMA" id="THFCASY"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="103" mass="11997" checksum="1AE173C045543FDA" modified="2009-07-28" version="1">MLKLFLRNKKRLGIFRTRIFEIDLKCSIFSKLATHFCASYSFATIQIRCNDLNKKETGKADGQTEKNRQSSFSSQSLFQTFHFMCDFPLSYVKRLAVTIAKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS40</accession>
    <name>C4YS40_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_04898</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of the enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="5"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS40"/>
    <dbReference type="SMR" id="C4YS40"/>
    <dbReference type="PaxDb" id="5476-C4YS40"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04898"/>
    <dbReference type="HOGENOM" id="CLU_038115_1_2_1"/>
    <dbReference type="OMA" id="YVMMDYD"/>
    <dbReference type="OrthoDB" id="2574at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.120:FF:000003">
        <property type="entry name" value="ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000123">
        <property type="entry name" value="HIS1p ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP-PRT_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403:SF8">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE ATP-PRTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP phosphoribosyltransferase catalytic" evidence="15">
        <location>
            <begin position="59"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine biosynthesis HisG C-terminal" evidence="16">
        <location>
            <begin position="218"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ46543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="298" mass="32605" checksum="FD33AF60BBFE3A0F" modified="2009-07-28" version="1">MDLVNHLPDRLLFAVPKKGRLYEKCCNLLSGADIQFRRSNRLDIALSTNLPIALIFLPAADIPVFVGEGNCDLGITGLDQIKEAEQFDNIEDLLDLKFGSCKLQIQVPADGEYEKPEQLVGKKIVSSFTKLSTDYFKQLSDKPTNIRYVGGSVEASCALGVADAIVDLVESGETMKAAGLKAIETILETSAHLISSKKSKFPEMVNIIVQRLQGVLAAQEYVLCNYNAPKSIQAKCLTITPGRRAATVSTLDKHSDDEEDWVAISSMVNRKEIGNVMDELKKAGATDILVLEISNCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS41</accession>
    <name>C4YS41_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alkyl transferase</fullName>
            <ecNumber evidence="12">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_04899</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate</text>
            <dbReference type="Rhea" id="RHEA:53008"/>
            <dbReference type="Rhea" id="RHEA-COMP:19494"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:136960"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms an active dehydrodolichyl diphosphate synthase complex with NUS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS41"/>
    <dbReference type="SMR" id="C4YS41"/>
    <dbReference type="PaxDb" id="5476-C4YS41"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04899"/>
    <dbReference type="HOGENOM" id="CLU_038505_0_0_1"/>
    <dbReference type="OMA" id="FDRRDLW"/>
    <dbReference type="OrthoDB" id="4173905at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1180.10:FF:000002">
        <property type="entry name" value="Alkyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="283"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="309"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ46544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="328" mass="37181" checksum="F37A75D02F2AAF68" modified="2010-10-05" version="1">MSDWVSTFPGYKQVLLTCKKMLGRIIMTGPVPQHVGIIMDGNRRYAKTHKIEIKEGHSLGFDTMASILELLYESGVKCATVYAFSIENFKRSQYEVKWLMELAKSKFTQINQHGLLCEEYGVKIRILGNTKLLPRDVLEILEKTEEITKNNTRAVLNVCFPYTSRDEITHSIKSVVDEATKGGIDITEEAIDRHLYTKDVPPLDLLVRTSGTFRLSDFLLWQTVSPECAVVFVDKLWPAFKPWDMLKILLNWGFNKYMYGNPNGYGVSSNLVVKTPVDGELINTPKSTTGLDRYSEDEETEVSSNNLGTEEDTVTSEEEDSEGIVKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS49</accession>
    <name>C4YS49_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="14">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAWG_04907</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS49"/>
    <dbReference type="PaxDb" id="5476-C4YS49"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04907"/>
    <dbReference type="HOGENOM" id="CLU_014271_4_1_1"/>
    <dbReference type="OMA" id="STQGRNM"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002068">
        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF5">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="17">
        <location>
            <begin position="57"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="18">
        <location>
            <begin position="394"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEQ46552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="589" mass="62835" checksum="DACF666C1CCF2CFE" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS80</accession>
    <name>C4YS80_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS80"/>
    <dbReference type="PaxDb" id="5476-C4YS80"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04939"/>
    <dbReference type="HOGENOM" id="CLU_026673_16_1_1"/>
    <dbReference type="OMA" id="YDYKDAQ"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="8"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="355" mass="38389" checksum="D3A289BF34760A6A" modified="2009-07-28" version="1">MKAAVVSNPVEPTKLTEVKEIPKPKIQDNEILVKAKAYAINPTDWKHIVFKMSQPGDVAGSDASGIVEEVGSQVTNFKKGDNVSSLVGNVSPDNGAFAEYFVAKPQGTIKYDHDLVSSSESKSSTIDSFEGAASVTVGLVTVGISFAHSLNIAKNKEKGDSILIWGGATATGILAIQVAKLVYNLNVIVTASPKNHEYLKDLGADHTLDYNDADVVSKLQSLGHIKFGLDTISNKDTFQKLYDATAGTPEVFLDSLLLLDGKSIKTDPARNVHWGYTLGYLVVQKEKVLGTQKLVQTPELVNDFNAWWENVLPTIINKVKHANLKILDEGLASANEGLQLSRDNKVSGQKIVFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSB5</accession>
    <name>C4YSB5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Dipeptidyl peptidase 3</fullName>
            <ecNumber evidence="4 15">3.4.14.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">Dipeptidyl aminopeptidase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 15">Dipeptidyl peptidase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_04978</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.</text>
            <dbReference type="EC" id="3.4.14.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M49 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.4" evidence="4 15"/>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSB5"/>
    <dbReference type="PaxDb" id="5476-C4YSB5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04978"/>
    <dbReference type="HOGENOM" id="CLU_011977_1_0_1"/>
    <dbReference type="OMA" id="QRYWIRD"/>
    <dbReference type="OrthoDB" id="4694525at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000001">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000002">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005317">
        <property type="entry name" value="Dipeptidyl-peptase3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007828">
        <property type="entry name" value="Dipeptidyl-peptidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15 17" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="16">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR007828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ46618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="700" mass="79737" checksum="6CC847CA3F5AA99C" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSD8</accession>
    <name>C4YSD8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="15">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="15">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ALA1</name>
        <name evidence="17" type="ORF">CAWG_05001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 15">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="15"/>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSD8"/>
    <dbReference type="PaxDb" id="5476-C4YSD8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05001"/>
    <dbReference type="HOGENOM" id="CLU_004485_5_0_1"/>
    <dbReference type="OMA" id="NKKDNFW"/>
    <dbReference type="OrthoDB" id="2423964at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070143">
        <property type="term" value="P:mitochondrial alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.40:FF:000003">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059090">
        <property type="entry name" value="ALA1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26023">
        <property type="entry name" value="ALA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 15" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="16">
        <location>
            <begin position="24"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="616"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="620"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="735"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="739"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ46641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="969" mass="108303" checksum="EF181CDABD647D8A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSK1</accession>
    <name>C4YSK1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B22 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_05069</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSK1"/>
    <dbReference type="SMR" id="C4YSK1"/>
    <dbReference type="PaxDb" id="5476-C4YSK1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05069"/>
    <dbReference type="HOGENOM" id="CLU_108081_1_1_1"/>
    <dbReference type="OMA" id="KWERNAP"/>
    <dbReference type="OrthoDB" id="13598at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20263">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045292">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="16">
        <location>
            <begin position="14"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ46704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="107" mass="12433" checksum="C9CFAC56EB74BDF3" modified="2010-10-05" version="1">MSSPILPFTEANSKRVTSLFRQALRTAYDHSMRWDVYRDATINIRRQFEANKHISSQQELEAVINKTKAKLAEWKHPDPYIPPCRPGGTKYQRNIPVAREPLVPGDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSK9</accession>
    <name>C4YSK9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSK9"/>
    <dbReference type="PaxDb" id="5476-C4YSK9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05077"/>
    <dbReference type="HOGENOM" id="CLU_008975_0_0_1"/>
    <dbReference type="OMA" id="HNERTND"/>
    <dbReference type="OrthoDB" id="4014434at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="702"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="870" mass="96841" checksum="CEF8DB7F08597B50" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT00</accession>
    <name>C4YT00_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_05697</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT00"/>
    <dbReference type="PaxDb" id="5476-C4YT00"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05697"/>
    <dbReference type="HOGENOM" id="CLU_001882_4_1_1"/>
    <dbReference type="OMA" id="EVYWVTH"/>
    <dbReference type="OrthoDB" id="1350766at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000007">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="entry name" value="YbaK/aminoacyl-tRNA synthetase-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="YbaK/ProRS associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="230"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="633"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ47136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="691" mass="77385" checksum="CD3954A2B3148161" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT05</accession>
    <name>C4YT05_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="7">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_05702</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="7"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="C4YT05"/>
    <dbReference type="PaxDb" id="5476-C4YT05"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05702"/>
    <dbReference type="HOGENOM" id="CLU_002738_1_2_1"/>
    <dbReference type="OMA" id="HWQREMS"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PH_PLC_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
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    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
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        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037755">
        <property type="entry name" value="Plc1_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
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        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="796"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="742"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="30"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="743"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ47141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1100" mass="124565" checksum="F78FBD545A4375B2" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTP2</accession>
    <name>C4YTP2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="18012" checksum="527713F41056C271" modified="2010-10-05" version="1">MTILGGSHKFSTNFKLVLLVLYVYLRINKNPSLLYYCVYNLKRWSWWSLLFSNSTANSKSEHTSYLAQLGYSVLVKEVVMVTGFLNELSMSNKLDSWLDVFGIFFFFCFSWCLLVGVGVFCCRPPPIVHLLLTTTTTVRFVPLYCMRGECFKMSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTY4</accession>
    <name>C4YTY4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sfi1 spindle body domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTY4"/>
    <dbReference type="PaxDb" id="5476-C4YTY4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05632"/>
    <dbReference type="HOGENOM" id="CLU_261453_0_0_1"/>
    <dbReference type="OMA" id="WDRATVR"/>
    <dbReference type="OrthoDB" id="4070448at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013665">
        <property type="entry name" value="Sfi1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08457">
        <property type="entry name" value="Sfi1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sfi1 spindle body" evidence="2">
        <location>
            <begin position="399"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Sfi1 spindle body" evidence="2">
        <location>
            <begin position="538"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1004"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1025"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ47075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1120" mass="132539" checksum="8B407FF33F553DD2" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCN2</accession>
    <name>C4YCN2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cell wall mannoprotein PIR1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_00266</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PIR protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCN2"/>
    <dbReference type="PaxDb" id="5476-C4YCN2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00266"/>
    <dbReference type="HOGENOM" id="CLU_061202_1_0_1"/>
    <dbReference type="OMA" id="RDLHIVY"/>
    <dbReference type="OrthoDB" id="5415592at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054508">
        <property type="entry name" value="PIR1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051153">
        <property type="entry name" value="Yeast_CWMannoprotein_PIR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254:SF1">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22799">
        <property type="entry name" value="PIR1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946353" description="Cell wall mannoprotein PIR1-like C-terminal domain-containing protein" evidence="7">
        <location>
            <begin position="19"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall mannoprotein PIR1-like C-terminal" evidence="8">
        <location>
            <begin position="172"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ42068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="201" mass="23134" checksum="4D8453E1BAAA6981" modified="2009-07-28" version="1" fragment="single">MKFSLATATLGLIAIAQATLTPYSGYSGYSGGDDDKYRHGKSGIETLRGKFALAVKELSGYEHGKHKDRDLHIVYEIDDGQLQYGDRKDYIYYPYRNENSEEECSDEDDDHHKKKKRPHRHGGKSDDDDDDKKWKRGGDYSDENDNDSDDDLRFLTISYNDKYDFFTLKNTVLHDEKGATGEIVANHQFQFDKPPQKDALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCV6</accession>
    <name>C4YCV6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_00340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCV6"/>
    <dbReference type="PaxDb" id="5476-C4YCV6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00340"/>
    <dbReference type="HOGENOM" id="CLU_066963_2_1_1"/>
    <dbReference type="OMA" id="YYICISC"/>
    <dbReference type="OrthoDB" id="3427at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944636" description="GOLD domain-containing protein" evidence="8">
        <location>
            <begin position="23"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="9">
        <location>
            <begin position="32"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ42142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="218" mass="25200" checksum="6D031FB25592C4A7" modified="2009-07-28" version="1">MFSLSSSKCVAILVMLLQLSNALHFYVKTGETKCFYEELPENTLVVGKIDAYEKQDHSNEYFKNPNLKVQIIVEETFDNNHKVANQKSAPDGDFAFTSLDSGEHRFCLTPVYSDNTNNKVHRIFFDVAQGSANEYVDSKSTRMVDDLTGKVNQLYDKLDKIHWEQEHMREREATFRDQSESTNSRVVKWSIVQLIVLVGTCVYQLRHLKSFFVKQKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCX1</accession>
    <name>C4YCX1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenosine 5'-monophosphoramidase HNT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Histidine triad nucleotide-binding protein HNT1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_00355</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine 5'-phosphoramidate + H2O = NH4(+) + AMP</text>
            <dbReference type="Rhea" id="RHEA:67916"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57890"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:67917"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HINT family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCX1"/>
    <dbReference type="SMR" id="C4YCX1"/>
    <dbReference type="PaxDb" id="5476-C4YCX1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00355"/>
    <dbReference type="HOGENOM" id="CLU_056776_3_0_1"/>
    <dbReference type="OMA" id="YRVVMNC"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000013">
        <property type="entry name" value="Hit family protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="12">
        <location>
            <begin position="8"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="10 11">
        <location>
            <begin position="104"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="9">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ42157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="152" mass="16986" checksum="CFE47D525801B5FA" modified="2010-10-05" version="1">MASHASCIFCKIIKGEIPSFKLIETAKTYSFLDIQPIAEAHVLIIPKHHGAKLHNIPDDYLSDILPVVKKLTKVLKLDENNTPEGEGYNVLQNNGRIAHQVVDHVHFHLIPKKDEATGLGVGWPAEATDFDKLGKLHEKLKEELAKVDNEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD31</accession>
    <name>C4YD31_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD31"/>
    <dbReference type="PaxDb" id="5476-C4YD31"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00419"/>
    <dbReference type="HOGENOM" id="CLU_394915_0_0_1"/>
    <dbReference type="OMA" id="RDWKFKN"/>
    <dbReference type="OrthoDB" id="5351126at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="743" mass="84880" checksum="79DE058B448E267B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD67</accession>
    <name>C4YD67_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAM1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Outer kinetochore protein DAM1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_00457</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="15">Component of the DASH complex consisting of ASK1, DAD1, DAD2, DAD3, DAD4, DAM1, DUO1, HSK3, SPC19 and SPC34, with a stoichiometry of one copy of each subunit per complex. Multiple DASH complexes oligomerize to form a ring that encircles spindle microtubules and organizes the rod-like NDC80 complexes of the outer kinetochore. DASH complex oligomerization strengthens microtubule attachments. Within the complex, DAM1 and DUO1 may form the microtubule connections. On cytoplasmic microtubules, DASH complexes appear to form patches instead of rings. Interacts with the outer kinetochore component NDC80; the interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD67"/>
    <dbReference type="SMR" id="C4YD67"/>
    <dbReference type="PaxDb" id="5476-C4YD67"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00457"/>
    <dbReference type="HOGENOM" id="CLU_092107_0_0_1"/>
    <dbReference type="OMA" id="PKIHYPV"/>
    <dbReference type="OrthoDB" id="5586015at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990537">
        <property type="term" value="C:mitotic spindle polar microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013962">
        <property type="entry name" value="DASH_Dam1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08653">
        <property type="entry name" value="DASH_Dam1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="147"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="199"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ42253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="277" mass="31906" checksum="049FEDAD241ED124" modified="2009-07-28" version="1">MSSSKPVTPRNDRRQNSGRRHSHRSSGIQLPSMSPKVHHYPIDAENLPMDSPEIVEKFASLAESMETLDLHMHDLCHIHDHISNQFNESFASFLYGLSMTMWCVDFPGCPSREQWEALISKRERKERIEVLKKRLADAQKLNDRLKLRLSDEAKQKPQQLTSQQRPTHGPTRQIKQQPRSVNFNTHSSDSISTNSYTSGDFNTNRRVSRIPQPSRSNLPSSRFQAPSKSGPNLNQPPRYMRGLFDGNNTLNTSNYSRIKKPIHNRSVNNLQNRPPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDC8</accession>
    <name>C4YDC8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_00520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDC8"/>
    <dbReference type="PaxDb" id="5476-C4YDC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00520"/>
    <dbReference type="HOGENOM" id="CLU_009030_1_0_1"/>
    <dbReference type="OMA" id="ARQIMFE"/>
    <dbReference type="OrthoDB" id="3477330at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="318"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="493"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="914"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="318"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="458"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="914"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ42314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1103" mass="125086" checksum="2D50BC1578690A61" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDL3</accession>
    <name>C4YDL3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Telomerase reverse transcriptase</fullName>
            <ecNumber evidence="2 13">2.7.7.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Telomerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_00610</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Chromosome</location>
            <location evidence="13">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the reverse transcriptase family. Telomerase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2 13"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDL3"/>
    <dbReference type="PaxDb" id="5476-C4YDL3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00610"/>
    <dbReference type="HOGENOM" id="CLU_012565_0_0_1"/>
    <dbReference type="OMA" id="CYDSIPR"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000333">
        <property type="term" value="C:telomerase catalytic core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003720">
        <property type="term" value="F:telomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01648">
        <property type="entry name" value="TERT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021891">
        <property type="entry name" value="Telomerase_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003545">
        <property type="entry name" value="Telomerase_RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066:SF0">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12009">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01365">
        <property type="entry name" value="TELOMERASERT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00975">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9 13" id="KW-0779">Telomere</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="14">
        <location>
            <begin position="356"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ42399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="835" mass="97155" checksum="04D5B9CE6765B250" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDR0</accession>
    <name>C4YDR0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cell wall mannoprotein PIR1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_00657</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PIR protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDR0"/>
    <dbReference type="PaxDb" id="5476-C4YDR0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00657"/>
    <dbReference type="HOGENOM" id="CLU_689094_0_0_1"/>
    <dbReference type="OMA" id="PIAFQCH"/>
    <dbReference type="OrthoDB" id="5415592at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054508">
        <property type="entry name" value="PIR1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051153">
        <property type="entry name" value="Yeast_CWMannoprotein_PIR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254:SF1">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22799">
        <property type="entry name" value="PIR1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946709" description="Cell wall mannoprotein PIR1-like C-terminal domain-containing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall mannoprotein PIR1-like C-terminal" evidence="8">
        <location>
            <begin position="338"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="155"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="249"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ42446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="422" mass="48491" checksum="63AB5988856481DC" modified="2009-07-28" version="1">MIHYLIFPILLIFFQIIKSSGYYVPANGDDWTILKPPSCKNKLPGQYIDSLPFTFGIVVNPYILNEDGDYEKPIVSKIKPSLTTTTFVTSIITTSTATAPGSKPTKTKDIIVQIHDGQVQKMKHKHDYSSGGGDDDDDDEDCFDEKNIDMAAKRDYQDMNTQEQANEDSGQVLAESDSHQQVVDQNQQINEEEEETQEQQMQEENNNTNEIEDNKVQEFETIEEIYDDIDNNESRPNNSKKYHKKRPHNNYENKHGHKDYHEDHHHNHRYKDHENGHEEDDHKWNKPKPMPEQEEQEQEQEQKPKHEKSEGYESEFVSPVYSVACYTNSTLKMTLTDGILRDSDDRIGCIVSGHQFQFDGPTPQHGAIYAAGWSVTKQGQLALGDSTKFYQCASGDFYNLYDEPIAFQCHPVTLDVVELIEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDV3</accession>
    <name>C4YDV3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome assembly protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Elongation factor-like 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_00701</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDV3"/>
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</entry>
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            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Logue M.E."/>
                <person name="Martin R."/>
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                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEI2"/>
    <dbReference type="SMR" id="C4YEI2"/>
    <dbReference type="PaxDb" id="5476-C4YEI2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00939"/>
    <dbReference type="HOGENOM" id="CLU_130038_1_1_1"/>
    <dbReference type="OMA" id="ELMMAPN"/>
    <dbReference type="OrthoDB" id="249087at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000255">
        <property type="entry name" value="Elc1 elongin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="ELONGIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="8"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ42718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="100" mass="11374" checksum="9043C27025D900F7" modified="2010-10-05" version="1">MSLLNTEFVTLVSSDNFKFVISKDVASISSVLRNSQGFEEGKTGKIKLDMDGDILECIVEYLYYHYKYKDSVTEGKDIPEFNIPTHLALELLVKADYLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEM4</accession>
    <name>C4YEM4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_00981</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEM4"/>
    <dbReference type="PaxDb" id="5476-C4YEM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00981"/>
    <dbReference type="HOGENOM" id="CLU_045495_2_2_1"/>
    <dbReference type="OMA" id="PMEQFIK"/>
    <dbReference type="OrthoDB" id="2573941at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="33"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="135"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="135"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ42760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="258" mass="30874" checksum="ECCBC9DAC6EF17DB" modified="2009-07-28" version="1">MNTIKQINQINQKELNSQTSYKSSWHYDYRDTNYLYIGNIPYNLTTKDLIIIFSQYGIPTHINLIKDKESSKHHRGFGFLKYANFKSCILAIDNFNGIKLGDRYLKVDHNYYKLRGDENEDDYLIDYEEIKREMEEKEKKEKKEKRVDDDGRLIEGNKEIKEIKGGEKKEEEEEEDNEEDNDNNDDDEFKDPMAQYLTKTNDKERDDDDDEFKDPMEQFIKDKKKKSGKHRSSHRSSHRSSHRSSHHKSKDREKSPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YER5</accession>
    <name>C4YER5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_01023</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YER5"/>
    <dbReference type="PaxDb" id="5476-C4YER5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01023"/>
    <dbReference type="HOGENOM" id="CLU_034311_1_0_1"/>
    <dbReference type="OMA" id="DLWELQP"/>
    <dbReference type="OrthoDB" id="409956at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF16">
        <property type="entry name" value="D-AMINO ACID OXIDASE (AFU_ORTHOLOGUE AFUA_5G11290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946573" description="FAD dependent oxidoreductase domain-containing protein" evidence="7">
        <location>
            <begin position="18"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="45"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ42801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="361" mass="40267" checksum="52E89DA2D1A74E1F" modified="2009-07-28" version="1">MTSVVVLGAGVIGLTTALELKRSNAKLDITIVADHLPGDIDHTYTSPFAGANWHSFATPEDKRLQEIDKPGYKKFLQLAAADPRSGIWAVDNLSMYTDYEVTSNNGNYRKFVPWFKDFVDGFEIVDKSKLPEGIAFAHKFKGVVISVHTYLNYLVQQNKEIGNIIKRIPQIHHIEDARKFHSSGKKADYVINAAGLNASKIKGVEDKKFNFPVRGQVLLVKNNAKIQLGVEGFPGLPNEMLYMMPRKEGGTIIGGCFLEGNTSVSEDKELTARIIKRAIKYAPELVDPNYKNNPSKIEIVKVNVGFRPFREDGARVEVDKKYKWLIHNYGAGAGGYQGSFGLSKLVVDIMEKELSKFKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YES5</accession>
    <name>C4YES5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_01033</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YES5"/>
    <dbReference type="PaxDb" id="5476-C4YES5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01033"/>
    <dbReference type="HOGENOM" id="CLU_019858_0_0_1"/>
    <dbReference type="OMA" id="AKLWFYI"/>
    <dbReference type="OrthoDB" id="1713558at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013586">
        <property type="entry name" value="PSMD3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08375">
        <property type="entry name" value="Rpn3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="135"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ42811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="379" mass="43349" checksum="7BFCC931C1D327E5" modified="2009-07-28" version="1">MDVDNTTLIPEIELYIHLLVQVYLLDTGKLEELNSLGEHVVQLMKSFNRRSLDFIQAKVWFYVCRAKELIGDLYSIRPELSYSLRTATLRHDIETTASVITLLLRNYLLTHDISQASDLVEKVEFPENAGNALVARYYYYLARINAIQLDYSTANECVITAIRKAPQTSLANGFVQAATKLSIVIELLMGDIPELKVFKNKSGNLEPYFNVTKAVRLGDIKLFGEVLHKFEADFKKDDNFTLVSRLRQNVIKTGIRIISLSYSKISLKDICIKLHLDSEESTEYIVSKAIRDGVIEASINHQKGYMQSKELLDVYSTKLPQAEFDQRIKFCLSLHNESVKSMRYPNDNEKENANKEIEPSEEVELLKAIEEGDLDDFMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF06</accession>
    <name>C4YF06_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_01116</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF06"/>
    <dbReference type="PaxDb" id="5476-C4YF06"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01116"/>
    <dbReference type="HOGENOM" id="CLU_008074_2_0_1"/>
    <dbReference type="OMA" id="PTYYKLA"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009644">
        <property type="entry name" value="FKTN/MNN4/W02B3.4-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407">
        <property type="entry name" value="FUKUTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407:SF28">
        <property type="entry name" value="RIBITOL-5-PHOSPHATE TRANSFERASE FKTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="6">
        <location>
            <begin position="483"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ42892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="720" mass="85627" checksum="3893E49FEC68BB1D" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF30</accession>
    <name>C4YF30_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyl transferase 48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF30"/>
    <dbReference type="PaxDb" id="5476-C4YF30"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01141"/>
    <dbReference type="HOGENOM" id="CLU_501514_0_0_1"/>
    <dbReference type="OMA" id="YECHDER"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl transferase 48" evidence="1">
        <location>
            <begin position="115"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="543" mass="62962" checksum="DDBBBFBBE21BEE3B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF52</accession>
    <name>C4YF52_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Autophagy protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_01163</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Conjugated with ATG12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Preautophagosomal structure membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ATG5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF52"/>
    <dbReference type="SMR" id="C4YF52"/>
    <dbReference type="PaxDb" id="5476-C4YF52"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01163"/>
    <dbReference type="HOGENOM" id="CLU_051894_2_0_1"/>
    <dbReference type="OMA" id="SIQKAVW"/>
    <dbReference type="OrthoDB" id="272162at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.190">
        <property type="entry name" value="Autophagy protein Apg5, helix rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007239">
        <property type="entry name" value="Atg5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048940">
        <property type="entry name" value="ATG5_HBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042526">
        <property type="entry name" value="Atg5_HR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048939">
        <property type="entry name" value="ATG5_UblA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042527">
        <property type="entry name" value="Atg5_UblA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048318">
        <property type="entry name" value="ATG5_UblB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040:SF2">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20637">
        <property type="entry name" value="ATG5_HBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20638">
        <property type="entry name" value="ATG5_UblA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04106">
        <property type="entry name" value="ATG5_UblB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="5 7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Autophagy protein ATG5 UblA" evidence="10">
        <location>
            <begin position="14"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 alpha-helical bundle region" evidence="9">
        <location>
            <begin position="137"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 UblB" evidence="8">
        <location>
            <begin position="197"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ42938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="278" mass="32199" checksum="35DD724D151B5020" modified="2009-07-28" version="1">MNDIDNLAEIKKKLWNGSINVKILLNIEDQIIEYLLTIPRNSYFPTVFPQLIRYFQNFITTIELSKVPIWLEFEEVPLKWNLPVGVLYDYLYLPALLNDHDLGCWTISMKYEPVYPIEYIIPFNEKLAGDGQIDYMKTMNRILMNQLKQSCFVLNGTAKPIMQLSEANTNQLWKSLISRNLGDFNVLNKKIIKTIDRIPVKIYIAGSPIVVQAPISKDQTLQEILSLHTPNLSSSSSSMSHPYIQGIDVTSLMNQSIREIWQLFKHLDNFLYITLIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF75</accession>
    <name>C4YF75_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-activated protein kinase glycogen-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_01187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF75"/>
    <dbReference type="PaxDb" id="5476-C4YF75"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01187"/>
    <dbReference type="HOGENOM" id="CLU_708071_0_0_1"/>
    <dbReference type="OMA" id="EYNTAAN"/>
    <dbReference type="OrthoDB" id="5873279at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-activated protein kinase glycogen-binding" evidence="3">
        <location>
            <begin position="7"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ42961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="366" mass="40555" checksum="26D06FBCEA6AC4DB" modified="2009-07-28" version="1">MTLYTYTIRWPLKDENIHSIQITGNFDNWSRSLPTIKSTKEYLQEIKLESRQDVVFKFIINDDQWIVNDQFKVTHDEHGNSNNIIYADELVEEVDKENKANTGATSESKDKENAPESSLSETTVAPKPEAKSASKPIALKNDNDANDLPEPTIQKEQPKSTEQHESLEATGIEDHESFVEPVVSSKSPSKSIITEDDIISDIDSHGDNVPKKSGDLPQPSSTQQTLNQVLTPSSSFAAVSSPPVSSDYEHLDTKHEDQETEYNTAANSGVSTDTQGNEIVSTFQENKPVKPVLLPHDSESTLERTGSETNTNNNNSPRIPGHYPSSPEHKSSSTASLQSGNNAGENDSQYTGKRESLISRLRNLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF89</accession>
    <name>C4YF89_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor MBP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_01201</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to MCB elements (Mlu I cell cycle box) found in the promoter of most DNA synthesis genes. Transcriptional activation by MBF has an important role in the transition from G1 to S phase. It may have a dual role in that it behaves as an activator of transcription at the G1-S boundary and as a repressor during other stages of the cell cycle.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF89"/>
    <dbReference type="SMR" id="C4YF89"/>
    <dbReference type="PaxDb" id="5476-C4YF89"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01201"/>
    <dbReference type="HOGENOM" id="CLU_009666_2_0_1"/>
    <dbReference type="OMA" id="VDVYECY"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000004">
        <property type="entry name" value="Transcription factor MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF7">
        <property type="entry name" value="REGULATORY PROTEIN SWI4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="401"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="528"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="96"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="279"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="716"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ42975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="999" mass="112186" checksum="62D729DDCF6B3463" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFJ9</accession>
    <name>C4YFJ9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cns1/TTC4 wheel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_01317</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TTC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFJ9"/>
    <dbReference type="PaxDb" id="5476-C4YFJ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01317"/>
    <dbReference type="HOGENOM" id="CLU_040446_0_0_1"/>
    <dbReference type="OMA" id="WRAAQCA"/>
    <dbReference type="OrthoDB" id="420195at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21381">
        <property type="entry name" value="CTWD_TTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000560">
        <property type="entry name" value="CNS1p TPR-containing co-chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044059">
        <property type="entry name" value="Csn1/TTC4_wheel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18972">
        <property type="entry name" value="Wheel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="162"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Cns1/TTC4 wheel" evidence="6">
        <location>
            <begin position="263"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="195"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ43080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="390" mass="45096" checksum="8F04396BB597D1D4" modified="2009-07-28" version="1">MSKIEPVTEKEGEYVSEWDRRRYVPKAGEPELPPQLSEFSNKTTDEVIEELNRLPFFMTKLDETDGDGGENVNLEALKSLAYEGDPDEIASNFKNQGNNCYKFKKYKDAIIFYTKGLEVNCDVDAINSALYLNRAACNLELKNYRRCIEDCKKVLMLDEKNIKACFRSGKAFFAIEKYDEAIKVLEYGLNIEPENKDLQKLLQQVQKRQETLAQIKAKKAQEEEQERLKNIVLENSIKLRHIEIVKSSSPPEVLKTAKIRLEDPKDYQSQLIFPAMILYPTTDEFDFIAEISELTTPLELLEMVLNRPREWFDDPKHKDFNVKKLECFMETESGGLIKVGKKIEVNNALMNEKPKAPLFDNALRLYVVPKLDVAKWTSEWNKETALAARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFL7</accession>
    <name>C4YFL7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">N-terminal acetyltransferase B complex subunit MDM20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2017" name="Structure" volume="25" first="641" last="649.e3">
            <title>Molecular Basis of Substrate Specific Acetylation by N-Terminal Acetyltransferase NatB.</title>
            <authorList>
                <person name="Hong H."/>
                <person name="Cai Y."/>
                <person name="Zhang S."/>
                <person name="Ding H."/>
                <person name="Wang H."/>
                <person name="Han A."/>
            </authorList>
            <dbReference type="PubMed" id="28380339"/>
            <dbReference type="DOI" id="10.1016/j.str.2017.03.003"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM20/NAA25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PDB" id="5K04">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.40 A"/>
        <property type="chains" value="A=1-745"/>
    </dbReference>
    <dbReference type="PDB" id="5K18">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.73 A"/>
        <property type="chains" value="A/C=1-745"/>
    </dbReference>
    <dbReference type="PDBsum" id="5K04"/>
    <dbReference type="PDBsum" id="5K18"/>
    <dbReference type="AlphaFoldDB" id="C4YFL7"/>
    <dbReference type="SMR" id="C4YFL7"/>
    <dbReference type="PaxDb" id="5476-C4YFL7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01335"/>
    <dbReference type="HOGENOM" id="CLU_019572_0_0_1"/>
    <dbReference type="OMA" id="LPQLAYK"/>
    <dbReference type="OrthoDB" id="1874341at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF3">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="5K04"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="5K18"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="745" mass="87051" checksum="9D8A0EE7F2DECBC0" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFQ2</accession>
    <name>C4YFQ2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 subunit G</fullName>
            <shortName evidence="6">eIF3g</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 RNA-binding subunit</fullName>
            <shortName evidence="6">eIF-3 RNA-binding subunit</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Translation initiation factor eIF3 p33 subunit homolog</fullName>
            <shortName evidence="6">eIF3 p33 homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TIF35</name>
        <name evidence="10" type="ORF">CAWG_00028</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-3 subunit G family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFQ2"/>
    <dbReference type="SMR" id="C4YFQ2"/>
    <dbReference type="PaxDb" id="5476-C4YFQ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00028"/>
    <dbReference type="HOGENOM" id="CLU_034595_0_0_1"/>
    <dbReference type="OMA" id="ICQGDHF"/>
    <dbReference type="OrthoDB" id="639027at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12933">
        <property type="entry name" value="eIF3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12408">
        <property type="entry name" value="RRM_eIF3G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03006">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017334">
        <property type="entry name" value="eIF3_g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024675">
        <property type="entry name" value="eIF3g_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034240">
        <property type="entry name" value="eIF3G_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12353">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037949">
        <property type="entry name" value="Transl_init_eIF-3_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="197"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="66"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ41841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="279" mass="30686" checksum="F97523CF62BE468E" modified="2009-07-28" version="1">MSTGLLDSWADAGDEFSAPPEVIANPDGTKTVITFRTNQDGKKVKITQKIKEVKVQEKVHPLIAQRKNWKKYGKEKNSPPGPDTSTTQLGEKVDLKLGTSWKQDEKKEEEDKAHERAQKIAVQTIKCRVCGGDHYTAKCPFKDTLGAAAGVTPSGTTPEPTSEGGAGAAGAGKYVPRHLRADANGNVPTREARDDSTTLKVSQLNSFVDEDMLRNELFAKFGPLQRVTIVRNRETGESRGFAYVSFATEEIAQRALDTFNGKGYHSLILHLEWSKKKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFY0</accession>
    <name>C4YFY0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Association with the SNF1 complex (ASC) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_00091</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFY0"/>
    <dbReference type="PaxDb" id="5476-C4YFY0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00091"/>
    <dbReference type="HOGENOM" id="CLU_445500_0_0_1"/>
    <dbReference type="OMA" id="IMHSPAD"/>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="3">
        <location>
            <begin position="562"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="594"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="655"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="500"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="612"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ41904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="745" mass="81955" checksum="9FF8069776EB3C3A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG86</accession>
    <name>C4YG86_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS9m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">37S ribosomal protein S9, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_00207</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YG86"/>
    <dbReference type="PaxDb" id="5476-C4YG86"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00207"/>
    <dbReference type="HOGENOM" id="CLU_036531_0_0_1"/>
    <dbReference type="OMA" id="RESAMWA"/>
    <dbReference type="OrthoDB" id="10254627at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000001">
        <property type="entry name" value="30S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_uS9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001099">
        <property type="entry name" value="PRK00132.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ42010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="334" mass="38452" checksum="DA3669DC12D850AD" modified="2009-07-28" version="1">MALRLITRFRGLNIPQRSLHQSTFRLNETIQSTTTTTTTTTTTFDEIPTTKPRFQSRFRRNQQPHQQQRSPYTSSQVTENLNIGEINRVRTVPTLMTYYGGNPVHEDNMNRLRAVLKKYQQLPVRVVPDREIQSQKFIGFDDYLEKTQSGTRVKKIHYRELITLLNRLRTIDLELMPLEVSEILSEYTSKSVSKITQLSREKTLDCFGRAKTQAKRKSSIAKIYLVKGEGEVLVNGKSLIEFFPNIYARKNLLYPFQVVEQEGKYNVFAQVTGGGYTGQSEAIMYAIAKALVVFNPLLKPRLSKAGLMKSDTRIVERKKPGKVKARKSPTWVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGL7</accession>
    <name>C4YGL7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_03196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGL7"/>
    <dbReference type="PaxDb" id="5476-C4YGL7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03196"/>
    <dbReference type="HOGENOM" id="CLU_1189771_0_0_1"/>
    <dbReference type="OMA" id="LNCYIAS"/>
    <dbReference type="OrthoDB" id="10425600at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946626" description="Cell wall protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="25117" checksum="F59058BE056D6C0E" modified="2010-10-05" version="1">MKFIILLFALIQITVAANRALIIDYSYYGCNLNCYIASNQENTCGAHDNDVSDQQYHSCLCMNYDYFTNLMNCNCFDSNVYYVSSSICSMATASSEFETYDGGPSTMNVSTTDYSSSTEDISFTEDVSFTADDSFTEYTSFTKYSSFTKYSSSVSSFTKVIWSTLETSSIKGIAATTSSYFTNSQTTSGTANDSSISKPSGTQIFVLCVISVVGFIFFFLFFLSLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGV3</accession>
    <name>C4YGV3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA repair and recombination protein RAD52</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_03287</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in DNA double-strand break (DSB) repair and recombination. Promotes the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGV3"/>
    <dbReference type="SMR" id="C4YGV3"/>
    <dbReference type="PaxDb" id="5476-C4YGV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03287"/>
    <dbReference type="HOGENOM" id="CLU_111192_0_0_1"/>
    <dbReference type="OMA" id="WSVQRIG"/>
    <dbReference type="OrthoDB" id="206565at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016810">
        <property type="entry name" value="Rad59"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022936">
        <property type="entry name" value="RAD59_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ44985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="215" mass="24972" checksum="E9DD9606D2754723" modified="2010-10-05" version="1">MTTSYLDTENDNDIDDNEEEEEEELANLPSTVKFFPNLSDLLDDEEYQDDDDDDGTNNNNTVINEWALRKFGTLQMKLEKMQHSRDTFQSFGSRDNLTNFSRNILYNLANEVFGFDGWSTTILDCNLTKRENKDENKYSALCVVKIRLILKDGTFREQSGQAESTNMPYKHMCYASARKKAVTDAIKNAIVGLRDLYLEYEQEQLMKQFAPEYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGY1</accession>
    <name>C4YGY1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_03322</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGY1"/>
    <dbReference type="PaxDb" id="5476-C4YGY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03322"/>
    <dbReference type="HOGENOM" id="CLU_066906_0_0_1"/>
    <dbReference type="OMA" id="KSATLWD"/>
    <dbReference type="OrthoDB" id="436519at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
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    <sequence length="278" mass="32247" checksum="944A0602E18DCB62" modified="2009-07-28" version="1">MDQTIAQIINDDIDLYAVLGVSSDSTPQDIRRAYRQKALLFHPDKYDGDETKFNLILKSYEILSDTSLKSKYDELCQIKLTKLENRAKLDDLTRRFQDELIASESKRQKHRHPDIESMKQEGLKKRRIQEQKLFNEKKTCTTIYDIPLNNNVSVSSTYANTTVSLKYKFKKELETLIDENVLSKIMSIFGEVTKVTMNGHDNRYAYAYIDFATIDGCNQALRHNYSESARKWDGTEVRKLASLLRECKKADTGNSDFTNNDKVNQILRDYLKSVNSRI</sequence>
</entry>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
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                <person name="Hube B."/>
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                <person name="Kodira C."/>
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                <person name="Logue M.E."/>
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                <person name="Neiman A.M."/>
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</entry>
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                <person name="Forche A."/>
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                <person name="Berriman M."/>
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                <person name="Lorenz M.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">WO-1</strain>
        </source>
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    <proteinExistence type="predicted"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ45081.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="842" mass="93392" checksum="2F704C70B66A2B89" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-10-14" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
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                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
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                <person name="Brown A.J."/>
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                <person name="Hoyer L.L."/>
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                <person name="Logue M.E."/>
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                <person name="Sherlock G."/>
                <person name="Shah P."/>
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                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major hyphal cell wall protein which plays a role of adhesin and is required for mating, normal hyphal development, cell-to-cell adhesive functions necessary for biofilm integrity, attachment to host, and virulence. Promotes interactions with host and bacterial molecules, thus leading to effective colonization within polymicrobial communities. Plays a crucial role in gastrointestinal colonization, in mucosal symptomatic and asymptomatic infections, in vaginitis, as well as in lethal oroesophageal candidiasis, caused by the combined action of fungal virulence factors and host inflammatory responses when protective immunity is absent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location>Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="1">Found in hyphal but not yeast forms.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">N- and O-glycosylated.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">As a major cell surface protein expressed during infection, HWP1 detection can be used for diagnosis of invasive candidiasis. HWP1 epitopes can also be used to develop vaccines for protection against candidiasis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HWP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHA6"/>
    <dbReference type="GlyCosmos" id="C4YHA6">
        <property type="glycosylation" value="3 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YHA6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03451"/>
    <dbReference type="HOGENOM" id="CLU_033728_0_0_1"/>
    <dbReference type="OMA" id="EPCDYPQ"/>
    <dbReference type="OrthoDB" id="10603075at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025928">
        <property type="entry name" value="Flocculin_t3_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13928">
        <property type="entry name" value="Flocculin_t3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0130">Cell adhesion</keyword>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0336">GPI-anchor</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000434105" description="Hyphal wall protein 1">
        <location>
            <begin position="28"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000434106" description="Removed in mature form" evidence="1">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="repeat" description="1; approximate" evidence="5">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="2; approximate" evidence="5">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="3; approximate" evidence="5">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="4" evidence="5">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="5" evidence="5">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="6" evidence="5">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="7" evidence="5">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="8" evidence="5">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="9" evidence="5">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="10" evidence="5">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="11" evidence="5">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="12" evidence="5">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="13; truncated" evidence="5">
        <location>
            <begin position="172"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="14; truncated" evidence="5">
        <location>
            <begin position="180"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="14 X 10 AA tandem repeats of [EVIQ]-P-[CDT]-D-[YNW]-P-[PQ]-[QI]-[QP]-[QDN]" evidence="5">
        <location>
            <begin position="46"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="411"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="42"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="115"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="193"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="507"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="GPI-anchor amidated glycine" evidence="1">
        <location>
            <position position="612"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P46593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="633" mass="65327" checksum="3C27A16BAF2CE59B" modified="2009-07-28" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHF8</accession>
    <name>C4YHF8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Abp1p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_03504</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHF8"/>
    <dbReference type="PaxDb" id="5476-C4YHF8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03504"/>
    <dbReference type="HOGENOM" id="CLU_459326_0_0_1"/>
    <dbReference type="OMA" id="FKEPRGA"/>
    <dbReference type="OrthoDB" id="5971719at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11281">
        <property type="entry name" value="ADF_drebrin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11819">
        <property type="entry name" value="SH3_Cortactin_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000302">
        <property type="entry name" value="Abp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF25">
        <property type="entry name" value="DREBRIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="ADF-H" evidence="5">
        <location>
            <begin position="5"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="490"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="588"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="139"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="355"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="551"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="148"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="360"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="452"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ45190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="648" mass="70572" checksum="83F805D7D2EEBB28" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHI5</accession>
    <name>C4YHI5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_03531</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHI5"/>
    <dbReference type="SMR" id="C4YHI5"/>
    <dbReference type="PaxDb" id="5476-C4YHI5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03531"/>
    <dbReference type="HOGENOM" id="CLU_028547_0_0_1"/>
    <dbReference type="OMA" id="YENVRPP"/>
    <dbReference type="OrthoDB" id="79480at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048800">
        <property type="entry name" value="Cac1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022043">
        <property type="entry name" value="CAF1A_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272:SF0">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A CAF-1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21796">
        <property type="entry name" value="Cac1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12253">
        <property type="entry name" value="CAF1A_dimeriz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromatin assembly factor 1 subunit A dimerization" evidence="6">
        <location>
            <begin position="321"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Chromatin assembly factor 1 subunit Cac1-like C-terminal" evidence="7">
        <location>
            <begin position="509"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="17"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="375"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="375"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ45217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="572" mass="66420" checksum="B585D7C515552DA3" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHP6</accession>
    <name>C4YHP6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_03595</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I LYR family. SDHAF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHP6"/>
    <dbReference type="SMR" id="C4YHP6"/>
    <dbReference type="PaxDb" id="5476-C4YHP6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03595"/>
    <dbReference type="HOGENOM" id="CLU_154777_1_1_1"/>
    <dbReference type="OMA" id="VEMYSSP"/>
    <dbReference type="OrthoDB" id="273010at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20268">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045295">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675:SF1">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="5">
        <location>
            <begin position="9"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ45278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="78" mass="9620" checksum="61D3530B10D08E5A" modified="2009-07-28" version="1">MARLSGLQRDVLQLYRKCIRMVKTKPTDTHEHWRNFIHEEFAKYQHLPKKQFNTIEYLIRNGHRKLEMYSNPQLKDIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHQ5</accession>
    <name>C4YHQ5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_03604</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHQ5"/>
    <dbReference type="SMR" id="C4YHQ5"/>
    <dbReference type="PaxDb" id="5476-C4YHQ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03604"/>
    <dbReference type="HOGENOM" id="CLU_047181_1_0_1"/>
    <dbReference type="OMA" id="ASCAEYI"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF73">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="19"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="162"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="24"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="132"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ45287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="332" mass="34728" checksum="939B7EB71311519A" modified="2010-10-05" version="1">MFSKVATRSFSSSASNAYKVAVLGAGGGIGQPLSLLLKLNHKVTDLALYDIRGAPGVAADVSHVPTNSTVKGYNPDQIEEALTGSDVIVIPAGVPRKPGMTRDDLFNTNASIVRDLAKAAADYAPNAAVCIISNPVNSTVPIVAEVFKSKGNYNPNKLFGVTTLDVLRAARFVSEVAGTNPVNENVPVVGGHSGVTIVPLLSQTKHKDLSGETRDALVHRIQFGGDEVVQAKDGAGSATLSMAQAGARFAGAVLDGLAGEKDVIECTFVDSPLFKDEGVDFFSTKVTLGVDGVKTVHPIGEISDYEEAQVKEAKDTLIKNIKKGVDFVAQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHX1</accession>
    <name>C4YHX1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_03674</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHX1"/>
    <dbReference type="PaxDb" id="5476-C4YHX1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03674"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OMA" id="PSNRYRI"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000313">
        <property type="entry name" value="MFS quinate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF8">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="56"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ45353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="612" mass="67346" checksum="CC1D3299ACCBC1A2" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIK1</accession>
    <name>C4YIK1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_04277</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="PaxDb" id="5476-C4YIK1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04277"/>
    <dbReference type="HOGENOM" id="CLU_008516_0_0_1"/>
    <dbReference type="OMA" id="MTRPHII"/>
    <dbReference type="OrthoDB" id="196165at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053039">
        <property type="entry name" value="Polarity_Bud-Selection_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="253"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="204"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="482"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="548"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="551"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="575"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="610"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="649"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="665"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="740"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="753"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ45936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="801" mass="91665" checksum="A9CEA882F33C6F9F" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIM7</accession>
    <name>C4YIM7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIM7"/>
    <dbReference type="PaxDb" id="5476-C4YIM7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04303"/>
    <dbReference type="HOGENOM" id="CLU_042860_3_0_1"/>
    <dbReference type="OMA" id="DQWHAFF"/>
    <dbReference type="OrthoDB" id="899at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000036">
        <property type="entry name" value="Damage response protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF76">
        <property type="entry name" value="CALCUTTA CUP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="2">
        <location>
            <begin position="27"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ45962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="129" mass="14924" checksum="A1345FF3431C14BA" modified="2009-07-28" version="1">MFGSKDKEPTEIFKNNEKLSIKDLPIFTRSQLAQYNGTDKPELYVGIRGYIYDVTSNSNSYGPGKAYHKLVGKDVSRLLGLNKLKLSEDSDEYTWYTDDLDEKQQGIIDDWVKFFKMRYNIVGVIVDHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIZ3</accession>
    <name>C4YIZ3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIZ3"/>
    <dbReference type="PaxDb" id="5476-C4YIZ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03805"/>
    <dbReference type="HOGENOM" id="CLU_186295_0_0_1"/>
    <dbReference type="OMA" id="KWTVHES"/>
    <dbReference type="OrthoDB" id="2122308at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="89" mass="10495" checksum="2C9BC71205484F98" modified="2009-07-28" version="1">MTRTNKWTVHEKRPQEPKWFTHNGHSDTDPTKVKKNGAGKNNWGQPGDELDDNEVRHYQKSSGRRNSNHEMNQERLNNLNDKLDNQLMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ18</accession>
    <name>C4YJ18_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_03830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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        <lineage>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
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        </source>
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        <location>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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</entry>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
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                <person name="Sakthikumar S."/>
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                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
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                <person name="Brown A.J."/>
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                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
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                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
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                <person name="Staggs R."/>
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                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
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                <person name="Gow N.A."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Probable cell surface metalloreductase. May be involved in iron or copper homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ferric reductase (FRE) family. AIM14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJU9"/>
    <dbReference type="PaxDb" id="5476-C4YJU9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04119"/>
    <dbReference type="HOGENOM" id="CLU_036508_0_0_1"/>
    <dbReference type="OMA" id="GRMAYCL"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF198">
        <property type="entry name" value="METALLOREDUCTASE AIM14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00463">
        <property type="entry name" value="AIM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="17">
        <location>
            <begin position="96"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding 8" evidence="18">
        <location>
            <begin position="246"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric reductase NAD binding" evidence="19">
        <location>
            <begin position="348"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF08030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEQ45783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="537" mass="62116" checksum="C78F426524D1632C" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJZ7</accession>
    <name>C4YJZ7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GTP-binding protein YPT7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_05789</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJZ7"/>
    <dbReference type="PaxDb" id="5476-C4YJZ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05789"/>
    <dbReference type="HOGENOM" id="CLU_041217_10_6_1"/>
    <dbReference type="OMA" id="TSWKDEF"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000086">
        <property type="entry name" value="Ras-related small GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ47226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="217" mass="23809" checksum="B25A84644338034D" modified="2009-07-28" version="1">MSSSSRKKTLLKVIILGDSGVGKTSLMQQFVNSKFSHQYKATIGADFLTKEITVDNNKSVTLQIWDTAGQERFQSLGVAFYRGADCCVLCFDVTNEKSLNNLTSWKDEFLVQSNVSNPQDFPFIIIGNKIDVDDSKKIPSLSKKLNNITNNQMGGLNYPVFETSAKDGVNVEAAFEVIAKMALQQEELNASNGNDVNDDYTVAINIHLDSEASACGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK18</accession>
    <name>C4YK18_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Iron-regulated transcriptional activator AFT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
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        </source>
    </evidence>
    <sequence length="457" mass="51219" checksum="601D10F284415239" modified="2009-07-28" version="1">MLFQTTLTPEQEECPITVRLEASASSIVRGCPGIPRSIPRIETVLNIRSINHSPFPLRSVSIKLMTKQKVMIPTKFGSSEAFKEFIIYEDPLTYQPPMGEFSQLLHGLDIPILIPIPKDLTPTGHSPTLGATTIHNLVVFVSLGNSASTESTFVDYFPVDIKMYDTLPIYRQYNEPIVESRYSSDNQTLVEVAIPVTSIGPGDNLKVMCTVKTNSANNKVKKHIALKQLTFQVKEILECFDGGLPPRKEFKLHTESKAFAKEINTQGTSQTFSIQFPYENEYLEMFTPKEDGSSNNTDITESFSTTIIESTNISKLKVLDKLPDGVPLTHIQGFTLSGKFYSIWFEIVIKVKLSHAKDIDIHIPIIVCPFNKESSTYILNWIMAECEVAKREFGKEFNRIYSSTSKYSEMVKLIDRFRQPPVVCDNGKIKGITDPIPNKSLPNISSNSNSNSGLCID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKU5</accession>
    <name>C4YKU5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_06104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKU5"/>
    <dbReference type="PaxDb" id="5476-C4YKU5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06104"/>
    <dbReference type="HOGENOM" id="CLU_083354_1_0_1"/>
    <dbReference type="OMA" id="AQYINDP"/>
    <dbReference type="OrthoDB" id="4018368at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946583" evidence="1">
        <location>
            <begin position="20"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="152" mass="16575" checksum="1A7E00D3C60D83FF" modified="2009-07-28" version="1">MKFFTAATTALLLSAQALAELTSYKLYAKSENTEVDGKGVSILHEGAGIYFVFLGTDSIDVTYDDVEKLLYVPVSSDIQFNFGTNADIVQFSVTPPVSVEIAEDGSVNFEGSDDLFAAQYINDPYNYSKDSYAVILRGKPHAIPIKLVAKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKV0</accession>
    <name>C4YKV0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_06109</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKV0"/>
    <dbReference type="PaxDb" id="5476-C4YKV0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06109"/>
    <dbReference type="HOGENOM" id="CLU_014928_1_0_1"/>
    <dbReference type="OMA" id="ILYFKMA"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF4">
        <property type="entry name" value="MEMBRANE CHANNEL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="3">
        <location>
            <begin position="118"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="305"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="647"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ47529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="776" mass="90343" checksum="64321C965DD44111" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKY4</accession>
    <name>C4YKY4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA repair and recombination protein RDH54</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">RAD homolog 54</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Recombination factor TID1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Two hybrid interaction with DMC1 protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAWG_06143</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in the recombinational repair of double-strand breaks (DSB) in DNA during mitosis and meiosis. Has DNA dependent ATPase activity. Promotes D-loop (displacement loop) formation with RAD51 recombinase. Modifies the topology of double-stranded DNA during the D-loop reaction to facilitate the invasion of the homologous duplex molecule by the initiating single-stranded DNA substrate. Required for adaptation from G2/M checkpoint arrest induced by a double strand break, by participating in monitoring the extent of single-stranded DNA produced by resection of DNA ends. This role is distinct from its roles in recombination. Promotes colocalization of RAD51 and DMC1 during meiotic recombination. Involved in crossover interference.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with RAD51 and DMC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKY4"/>
    <dbReference type="PaxDb" id="5476-C4YKY4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06143"/>
    <dbReference type="HOGENOM" id="CLU_000315_10_1_1"/>
    <dbReference type="OMA" id="KCQTHEL"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18004">
        <property type="entry name" value="DEXHc_RAD54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000058">
        <property type="entry name" value="RDH54p DNA-dependent ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="201"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="510"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00076096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00077864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00082011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEQ47563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="785" mass="88515" checksum="B5DB921DA60F414D" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLJ3</accession>
    <name>C4YLJ3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-processing factor 39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_01711</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLJ3"/>
    <dbReference type="PaxDb" id="5476-C4YLJ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01711"/>
    <dbReference type="HOGENOM" id="CLU_590499_0_0_1"/>
    <dbReference type="OMA" id="IELWISY"/>
    <dbReference type="OrthoDB" id="10265668at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001907">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein component, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204">
        <property type="entry name" value="PRE-MRNA PROCESSING PROTEIN PRP39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204:SF23">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT PRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ43474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="47451" checksum="E6C70219BD9C4A65" modified="2009-07-28" version="1">MSLINKQWSSISTELVQDPQNFELWQSLIEAAEWNEKRGINKSTSEEELNVLRTSYNSFLEKFPFQFKYWIRYAEWEFKLGNTSTAEQIYLRGLNTQLSHCIELWISYLNFKINTINDNISEILQKFEAARDLIGFHFFGFEFYELYLSFLDNYKNDNNEFEKKYYILLRIILEIPIYHYGIFYKKWFDLIDNLSKDEKLAKQIAPYIAPANEIATLASKKNTSIFNELKKRFTDAYIATQYHSFELYELEKKLIPKSNKNPQQDNDLRSRQELDAWMSYIDYLEIKQYPIKFIELVYYRFLYNARNYPQTWSKFADYYIYHAKFNKARKILTDGVKYVDDYKLLIKLVDLEIFLKNYQRAINLLISYIQYNSNVPIPIRDKVHQVKQLIDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLP6</accession>
    <name>C4YLP6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_01765</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the RFT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLP6"/>
    <dbReference type="PaxDb" id="5476-C4YLP6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01765"/>
    <dbReference type="HOGENOM" id="CLU_023360_3_0_1"/>
    <dbReference type="OMA" id="WPGKLFG"/>
    <dbReference type="OrthoDB" id="9979195at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034203">
        <property type="term" value="P:glycolipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007594">
        <property type="entry name" value="RFT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MULTISPAN TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117:SF5">
        <property type="entry name" value="PROTEIN RFT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04506">
        <property type="entry name" value="Rft-1"/>
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    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="136"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="519"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00010288"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ43527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="561" mass="64422" checksum="E2A7BA385F63D6D9" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLT8</accession>
    <name>C4YLT8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphoribosylformylglycinamidine synthase</fullName>
            <ecNumber evidence="4">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Formylglycinamide ribonucleotide amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Formylglycinamide ribotide amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CAWG_01807</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the FGAMS family.</text>
    </comment>
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    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01807"/>
    <dbReference type="HOGENOM" id="CLU_001031_0_2_1"/>
    <dbReference type="OMA" id="LSANWMW"/>
    <dbReference type="OrthoDB" id="6666987at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
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        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01740">
        <property type="entry name" value="GATase1_FGAR_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02203">
        <property type="entry name" value="PurL_repeat1"/>
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    </dbReference>
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        <property type="entry name" value="PurM-like, N-terminal domain"/>
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    </dbReference>
    <dbReference type="HAMAP" id="MF_00419">
        <property type="entry name" value="PurL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
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        <property type="entry name" value="FGAR-AT_N"/>
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        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
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        <property type="entry name" value="PurL_large"/>
    </dbReference>
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        <property type="entry name" value="PurL_linker"/>
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        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
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        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
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        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
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        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01735">
        <property type="entry name" value="FGAM_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRK05297.1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
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    </dbReference>
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        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FGAR-AT_N"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF13507">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01211">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109736">
        <property type="entry name" value="FGAM synthase PurL, linker domain"/>
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    </dbReference>
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        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="PurS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase N-terminal" evidence="20">
        <location>
            <begin position="42"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase linker" evidence="19">
        <location>
            <begin position="225"/>
            <end position="274"/>
        </location>
    </feature>
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        <location>
            <begin position="488"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="FGAR-AT PurM N-terminal-like" evidence="21">
        <location>
            <begin position="707"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="18">
        <location>
            <begin position="895"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012747"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF18076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF22689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EEQ43569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1370" mass="150811" checksum="21E490456386125E" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLW1</accession>
    <name>C4YLW1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLW1"/>
    <dbReference type="PaxDb" id="5476-C4YLW1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01831"/>
    <dbReference type="HOGENOM" id="CLU_963097_0_0_1"/>
    <dbReference type="OMA" id="TNENFPF"/>
    <dbReference type="OrthoDB" id="10411737at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="291" mass="33101" checksum="76A38BCC5892617A" modified="2009-07-28" version="1">MKRQHNDTISSNNSEFTKTKLRKTTNMTSYPSPTYSFEESSDYYRVPIGRPTTPVDKIINSLETMPISPIKNNKGELTFTPTTWTTSMDLYKVRPKTSPRPSPTPSPVGTPPPVRSPTPTPSPYPSPSPRQRQRQQQHCQTNQRLLSHNDLNSVLILPEMEIYLENEPKDKLQKLETTITTKNNLQITNCFNPFVCLNFNPFAPFTNSPYPFSYSQQQKTNANTKNAIVCPTLLPPPIFLSEENSTNKITNENFPFLFITGGSRTDNVVCTNPKCPCDAKPSYFVEKFFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLX3</accession>
    <name>C4YLX3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_01845</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLX3"/>
    <dbReference type="SMR" id="C4YLX3"/>
    <dbReference type="PaxDb" id="5476-C4YLX3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01845"/>
    <dbReference type="HOGENOM" id="CLU_037236_2_0_1"/>
    <dbReference type="OMA" id="RRYDYFY"/>
    <dbReference type="OrthoDB" id="413400at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052606">
        <property type="entry name" value="DnaJ_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946749" description="J domain-containing protein" evidence="8">
        <location>
            <begin position="17"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="42"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ43604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="300" mass="34975" checksum="F41CE5FB134FE5E9" modified="2009-07-28" version="1">MKFIKVFLLFVTIVVAAHWSKEDYEIFSLNDKLQQDLGHDITFYKWLGLEKGPKSNLQEITKAYRKLSRKLHPDKFASASRSDKKKANERFQRLSLVGNILKDQSLKRRYDYFYTKGFPKWKGTGYYYSKFRPGVIFTLIILYVLVGFLHFFSLKINRKQAFKRIVDLKNEVKNQAWGGLQFPPGDGSDRKLSNEATGKVFLVKADGTVWLVENDGEQHLIDEYDVNVNPGFKESLFFKIPVKIWNLILGKWVPIDTSVEYKKQETSPQEDDTKKKVQKKKSKGKKVELPNGKVVYSRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMC7</accession>
    <name>C4YMC7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="5">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF6</name>
        <name evidence="6" type="ORF">CAWG_02006</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <text evidence="5">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMC7"/>
    <dbReference type="SMR" id="C4YMC7"/>
    <dbReference type="PaxDb" id="5476-C4YMC7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02006"/>
    <dbReference type="HOGENOM" id="CLU_071894_0_0_1"/>
    <dbReference type="OMA" id="WCAFCGM"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ43758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="245" mass="26394" checksum="1E6EF3AADCE65ED7" modified="2010-10-05" version="1">MATRTQFENSNEVGVFSNLTNSYCLVAVGGSENFYSAFEAELGDVIPIVHTTIAGTRIVGRMTSGNRRGLLVPTQTTDQELMHLRNSLPDSIKIQRVEERLSALGNVICCNDYVALVHPDIERETEELIADVLGVEVFRQTIAGNVLVGSYCSLSNQGGLVHPQTSIQDQEELSSLLQVPLVAGTVNRGSSVVGAGMVVNDWLSVAGLDTTAPELSVIESIFRLQDAQPDAIGGNLRDTLIETYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMM9</accession>
    <name>C4YMM9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="14">Aconitase</shortName>
            <ecNumber evidence="14">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_02112</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="14">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="14"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMM9"/>
    <dbReference type="PaxDb" id="5476-C4YMM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02112"/>
    <dbReference type="HOGENOM" id="CLU_006714_2_2_1"/>
    <dbReference type="OMA" id="KKQGMLG"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01584">
        <property type="entry name" value="AcnA_Mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF3">
        <property type="entry name" value="ACONITATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 14" id="KW-0408">Iron</keyword>
    <keyword evidence="10 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="15">
        <location>
            <begin position="65"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="16">
        <location>
            <begin position="581"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ43860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="777" mass="84249" checksum="263E7C97CEFE25B0" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMT4</accession>
    <name>C4YMT4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U6 snRNA-associated Sm-like protein LSm1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LSM1</name>
        <name evidence="8" type="ORF">CAWG_02171</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a donut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMT4"/>
    <dbReference type="PaxDb" id="5476-C4YMT4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02171"/>
    <dbReference type="HOGENOM" id="CLU_076902_0_1_1"/>
    <dbReference type="OMA" id="FMVRGEN"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01728">
        <property type="entry name" value="LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000045">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034104">
        <property type="entry name" value="Lsm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF8">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="7">
        <location>
            <begin position="32"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="167" mass="19203" checksum="A2AECF8FC8B81A00" modified="2009-07-28" version="1">MSSVSSQSEQSRASDPLFQNVEDLYLESYAFTTAAAIVGSVDRKIFVLLKDGRNLFGILRTFDQFANLVLQDTLERIYLGEEGEAPTRFSETYRGVFMVRGENVVMLGEMDIDTEDDHLEKLEQVPFEVAERELKEQQAKKIREQKVKTKQLLQKGLINDFHITDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMV8</accession>
    <name>C4YMV8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_02195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:12045"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMV8"/>
    <dbReference type="ESTHER" id="canal-LIP7">
        <property type="family name" value="Fungal-Bact_LIP"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YMV8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02195"/>
    <dbReference type="HOGENOM" id="CLU_029538_5_0_1"/>
    <dbReference type="OMA" id="TTDSHFK"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ43939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="426" mass="47848" checksum="FCA9ABD650E5781C" modified="2009-07-28" version="1">MFVFLALITLTTCLQIPLNPTIDDFYNPPKDLETSQLGDVLKWRKMPFPVTSMFVNLPISNAWQISVRSQDTLNNSLAIVATILEPPNGDKNKLISHQAFENSPLLSCSPSYSMQVPSFETFQIQADLIFISGLLSQGWYVVVPDYEGPNSVFPVGRQSAYSVLDSIRGTIKFLNSTGNSTVKTALLGYSYGAVASLWASIVQPNYAPELELVGAAVGCTIPNITAFIEKVDEGPYSGLIVNIFNGLANEYRHFRDRLIHFGALQPLGCLFPICRKFFFQKMIGGVYDAQVLTDETIKETIEINNLLSTRAVPQIPVFLFHSKFNEMSPFLEILKLEKLWCSQLGVNLEIVEDMSYNHMVEAFSGMPAAITWIEKRWNNSTLGGCKHVHRLSNFEYPGIAPFLSQYFRSSLQMVLNNNRYFNNTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN90</accession>
    <name>C4YN90_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN90"/>
    <dbReference type="SMR" id="C4YN90"/>
    <dbReference type="PaxDb" id="5476-C4YN90"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02330"/>
    <dbReference type="HOGENOM" id="CLU_660841_0_0_1"/>
    <dbReference type="OMA" id="HYELDIE"/>
    <dbReference type="OrthoDB" id="10069473at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099122">
        <property type="term" value="F:RNA polymerase II C-terminal domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17003">
        <property type="entry name" value="CID_Rtt103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047883">
        <property type="entry name" value="Rtt103-like_CID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460:SF0">
        <property type="entry name" value="CID DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="335" mass="38306" checksum="135F1F67468D089D" modified="2010-10-05" version="1">MSFSATAFKFKLDTLSDTQESIVSISQWVLFHQKYYKESAKIWLNYITQDSITPAKRLSLLYLCNDVVQQARRKNKPEFINEFNKVLPDALSKNYGNLNPKVDRLLNVWEERKIFTEDEIANMKASLEAEPKPLESIDIAPQLKQINDLFVHLNKLNDINQENLTQMGIQSKTYLYPQDPETLPPAPVYLSKLYMLEKLGNVCINNVEEIKETRMKINSELDSLFNLIIDGTKTDDSKIANINEKIQKAKETIRDVNLTSMEAGSDDDDFPGYLSDSEEEEETKKRRLSQTPSGGSTPSKRVAFSEDVEVFEDPDENKEESVSVDVMSLLSKLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNA9</accession>
    <name>C4YNA9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNA9"/>
    <dbReference type="PaxDb" id="5476-C4YNA9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01365"/>
    <dbReference type="HOGENOM" id="CLU_053458_0_0_1"/>
    <dbReference type="OMA" id="APNFGPT"/>
    <dbReference type="OrthoDB" id="4028283at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021642">
        <property type="entry name" value="DUF3246"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11596">
        <property type="entry name" value="DUF3246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="424" mass="43348" checksum="2E5C24446F228D67" modified="2009-07-28" version="1" fragment="single">IEAPNSSPTILTLPITSQSKASVSSVVSKSTTEDNETDCETEIPTIIPTGSATIIPTGSGSITVLPTKSATSEDDDDETDCETDIPTIIPTGTATIKPTGSGSITVLPTKSTTTDDDDDETDCETEIPTIHPTVSTTRTFTSDGVPTTQTLTTKLPPTTNQHTETEVVSITYTGGGQTFTTYLAQSGEVCDETVTLTITTTCPSTTVAPGGQIYTTTVTVITTHTVYPDDWEDDGYEGEDNAGGSASGSSDDGEWEWYEEDDGECVPTGGSSSGSGTGSWWGSGAGSSGGTASGSGSGSSSNSGSGSSSSSGSSSGGTWGGSGNDYVCPGEDGYDDEDDQTPEPECDDEDDSWDDDEECDTQAAKEVVNSVTVAAESVYPSTTAASLTTSWISTQTAQSVTQIENIGGKVSASGLFVVLGLLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNE9</accession>
    <name>C4YNE9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL6 alpha-beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_01408</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNE9"/>
    <dbReference type="PaxDb" id="5476-C4YNE9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01408"/>
    <dbReference type="HOGENOM" id="CLU_065464_1_0_1"/>
    <dbReference type="OMA" id="RERHGLC"/>
    <dbReference type="OrthoDB" id="540873at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_uL6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_uL6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="5">
        <location>
            <begin position="170"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ43182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="233" mass="26260" checksum="A2FBC7940CCA9A18" modified="2009-07-28" version="1">MFTATKTATTTTTSICRLFSTSTKTLSNVGKKPIRLYEGVNYSIESIPVEFCKKFTKRNKTFTLDRQIITSGPLGKLRVEIPEFINISENNTNENDKSIIVSVKKPENKIQRSLWGTYRSILYNNIIGITEGHLSIVKFVGTGYRAILEKDPQTGEDIISLKIGLPFTPKLKIPKGLKVSSPNPARLVIEGSDKQQVKLFAAFIREHKKPEPYKGKGIFVDDEKIVLKQRKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNF3</accession>
    <name>C4YNF3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_01412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNF3"/>
    <dbReference type="PaxDb" id="5476-C4YNF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01412"/>
    <dbReference type="HOGENOM" id="CLU_1467950_0_0_1"/>
    <dbReference type="OMA" id="MTITQDS"/>
    <dbReference type="OrthoDB" id="4015054at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="184" mass="21378" checksum="A20120353898BE9E" modified="2009-07-28" version="1">MIELVSNSNHDWLSCYIIKLIITSQEELDLEINQFLTTTIVNSQLTLLIILHHEEEEGDNDSITDLQLLNYLQFEIYKQIGNDIIVSIMTITQDSNLSAMLSSQLKQIDDIVQYISKLDLSIALDVVNEEKLIFLMLNIPNLLPYLEEQQGYDEISIEELFENFVKHHNSIKKIMLSNELKEYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNK7</accession>
    <name>C4YNK7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_01469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNK7"/>
    <dbReference type="PaxDb" id="5476-C4YNK7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01469"/>
    <dbReference type="HOGENOM" id="CLU_1906464_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="133" mass="15303" checksum="2B4ED4D46AE64E3C" modified="2010-10-05" version="1">MNSVIFAPHFMSNTLVSIITNLYYQCNPSNSIPISYSNIRSFTRYSNVTSLIMGSLVDNSSIQRDYWESVIMVVMGDVAGVDRMQGNKRWQTKEKCEFIVVLIFCHTILLQNKSCVIKKKEITTMSFRLKTDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNY4</accession>
    <name>C4YNY4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">DNA polymerase</fullName>
            <ecNumber evidence="22">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">CAWG_02917</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20 22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="21">Forms DNA polymerase zeta with REV7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 22">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="22"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="C4YNY4"/>
    <dbReference type="PaxDb" id="5476-C4YNY4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02917"/>
    <dbReference type="HOGENOM" id="CLU_000203_3_1_1"/>
    <dbReference type="OMA" id="GRNKMGF"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05778">
        <property type="entry name" value="DNA_polB_zeta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05534">
        <property type="entry name" value="POLBc_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000007">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000156">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000002">
        <property type="entry name" value="DNA polymerase zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056435">
        <property type="entry name" value="DPOD/Z_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812:SF1">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24055">
        <property type="entry name" value="POL3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 22" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 22" id="KW-0235">DNA replication</keyword>
    <keyword evidence="16 22" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 22" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="14 22" id="KW-0408">Iron</keyword>
    <keyword evidence="15 22" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 22" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19 22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 22" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 22" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase delta/zeta catalytic subunit N-terminal" evidence="27">
        <location>
            <begin position="105"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="25">
        <location>
            <begin position="753"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="24">
        <location>
            <begin position="1045"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="26">
        <location>
            <begin position="1527"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="541"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00066055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF24055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="EEQ44643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1630" mass="188925" checksum="34AD753B5A08092C" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP46</accession>
    <name>C4YP46_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enoyl-CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YP46"/>
    <dbReference type="SMR" id="C4YP46"/>
    <dbReference type="PaxDb" id="5476-C4YP46"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02984"/>
    <dbReference type="HOGENOM" id="CLU_009834_7_0_1"/>
    <dbReference type="OMA" id="FQEACWA"/>
    <dbReference type="OrthoDB" id="14970at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000194">
        <property type="entry name" value="Enoyl-CoA hydratase/isomerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29030" checksum="7D330939D34E24FA" modified="2010-10-05" version="1">MSFDAKNYSDYEFFTISQIEPGFVHVQYTNPKTLNAFTEKNWRNYGEIFKRLDQESDVQLILVSSGVPRSFSSGLNLKAAMELFGSDEPRDQAIKHLHEHIVDFQDAIGIPSRISTPTIGVLNGLNLGLALDMSSAYSIRIAVKDAVFSIAEVNIGIAADIGSLQRLPSVVNNKSLLMQHALLGDKFGAEEALKLGFVSCVVDSIDEGVEFAKTLGEKICDAPAWAIKGTKKYIQHILNGGTVEEGLKSIAEYNAVNITDSKMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPM2</accession>
    <name>C4YPM2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H3-like centromeric protein CSE4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">CENP-A homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">CENPA homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_02423</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of centromeric nucleosomes, where DNA is wrapped around a histone octamer core. The octamer contains two molecules each of H2A, H2B, CSE4/CENPA and H4 assembled in one CSE4-H4 heterotetramer and two H2A-H2B heterodimers. Interacts with the inner kinetochore.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPM2"/>
    <dbReference type="SMR" id="C4YPM2"/>
    <dbReference type="PaxDb" id="5476-C4YPM2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02423"/>
    <dbReference type="HOGENOM" id="CLU_078295_3_0_1"/>
    <dbReference type="OMA" id="WQSHAIM"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000087">
        <property type="entry name" value="Probable histone 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="16">
        <location>
            <begin position="114"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ44161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="211" mass="24442" checksum="F75C3987B2EE29F2" modified="2009-07-28" version="1">MARLSGQSSGRQTGQGTSAEAIRQQREELRRQRELRLQQQQQAERQQQRQQYRTEQSPIVPAATSSSRYSQFGIYRNQPGDVVDTLASSLPRRTTTTRPEVNRTVPRVKKRYRPGTKALREIRQYQKSTDLLIRKLPFARLVREISLDFVGPSYGLRWQSNAILALQEASESFLIHLLEDTNLCAIHAKRVTIMQKDIQLARRIRGQSWIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPR1</accession>
    <name>C4YPR1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="2 8">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_02463</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2 8"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPR1"/>
    <dbReference type="SMR" id="C4YPR1"/>
    <dbReference type="PaxDb" id="5476-C4YPR1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02463"/>
    <dbReference type="HOGENOM" id="CLU_053879_3_1_1"/>
    <dbReference type="OMA" id="CGGIWAS"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071244">
        <property type="term" value="P:cellular response to carbon dioxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00883">
        <property type="entry name" value="beta_CA_cladeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF76">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00705">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ44200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="281" mass="31591" checksum="81828A5F8E120DFB" modified="2010-10-05" version="1">MGRENILKYQLEHDHESDLVTEKDQSLLLDNNNNLNGMNNTIKTHPVRVSSGNHNNFPFTLSSESTLQDFLNNNKFFVDSIKHNHGNQIFDLNGQGQSPHTLWIGCSDSRAGDQCLATLPGEIFVHRNIANIVNANDISSQGVIQFAIDVLKVKKIIVCGHTDCGGIWASLSKKKIGGVLDLWLNPVRHIRAANLKLLEEYNQDPKLKAKKLAELNVISSVTALKRHPSASVALKKNEIEVWGMLYDVATGYLSQVEIPQDEFEDLFHVHDEHDEEEYNPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ01</accession>
    <name>C4YQ01_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ01"/>
    <dbReference type="PaxDb" id="5476-C4YQ01"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02555"/>
    <dbReference type="HOGENOM" id="CLU_281042_0_0_1"/>
    <dbReference type="OMA" id="DTNCEAT"/>
    <dbReference type="OrthoDB" id="10643405at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946810" evidence="2">
        <location>
            <begin position="19"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="816"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="897"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="973"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="468"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="973"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1166" mass="121815" checksum="3DA4A1077017FB38" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ02</accession>
    <name>C4YQ02_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_02556</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
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                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
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                <person name="Staggs R."/>
                <person name="Stansfield I."/>
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                <person name="Zeng Q."/>
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                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
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            <end position="48"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <dbReference type="ARBA" id="ARBA00023177"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362002"/>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="Pfam" id="PF00909"/>
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    </evidence>
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            <dbReference type="EMBL" id="EEQ44291.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
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    </evidence>
    <sequence length="535" mass="59480" checksum="5F91BAE12F54DEB6" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ42</accession>
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        <name type="scientific">Candida albicans (strain WO-1)</name>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
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        <source>
            <strain evidence="3 4">WO-1</strain>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="Pfam" id="PF10407"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ44331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
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    </evidence>
    <sequence length="1286" mass="137942" checksum="69555E0FD78707F2" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ79</accession>
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        <submittedName>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Butler G."/>
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                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
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                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ79"/>
    <dbReference type="SMR" id="C4YQ79"/>
    <dbReference type="PaxDb" id="5476-C4YQ79"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02635"/>
    <dbReference type="HOGENOM" id="CLU_021555_2_2_1"/>
    <dbReference type="OMA" id="CGTDMSA"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF2">
        <property type="entry name" value="ALLANTOIN PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ44368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="570" mass="64364" checksum="270A6FF8173F1A0F" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQV2</accession>
    <name>C4YQV2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="GAPMSHK"/>
    <dbReference type="OrthoDB" id="4084571at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="107" mass="11916" checksum="C0D10A3B64B9565A" modified="2010-10-05" version="1">MPPKLSPSAAASSAQGAPMSHKIIVGTIAILLGGYVTYKAGSDFQFVKYTPHSPEEIERRKRENQTGISMKMSEELTLDLKPEAKQRIQKLLDEKNKSLDENQNNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQW6</accession>
    <name>C4YQW6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II transcription factor B subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">RNA polymerase II transcription factor B 38 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase II transcription factor B p38 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_04463</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YQW6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04463"/>
    <dbReference type="HOGENOM" id="CLU_048466_1_0_1"/>
    <dbReference type="OMA" id="PNKRDYY"/>
    <dbReference type="OrthoDB" id="5963at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
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        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="RING-HC_TFB3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000037">
        <property type="entry name" value="Cdk-activating kinase assembly factor MAT1, centre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004575">
        <property type="entry name" value="MAT1/Tfb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015877">
        <property type="entry name" value="MAT1_centre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00570">
        <property type="entry name" value="cdk7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683:SF13">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06391">
        <property type="entry name" value="MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17121">
        <property type="entry name" value="zf-C3HC4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="34"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="268"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="143"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ46119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="380" mass="44156" checksum="082B59F2C9160541" modified="2009-07-28" version="1">MLQTAEGMSTVYPLLASYNSSTNHIIDDQLKDMCPICKTDKYLSPNMKFLINPECYHKICESCVDRIFSLGPAPCPYPKCGKILRKNKFKQQIFEDLIIEKEIDIRKKVSAIYNKTEEDFPGDLQGYNRYLENIEDIIFKLSYSDDKQEIETVETELNKYEQEHKLEILERNMRESQRNDDLIKYKEARERLKQEKLKIQKQMELEDLEYQREQQQELLDKLTNSSTTSEELIKQQQNQMLKRSNLRRKQLQTINNQLDQQFNKINPFAKNNGVDSDDEQNGGGGGVNGSSKIPFTPFQGDRDLNKGYTMLPVPTDVESIMNIEQNISDSYYDPFINKLAKNKQYLGGGWRLQNVFQQALDEAFIGLGCNIELEKATTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR07</accession>
    <name>C4YR07_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="3">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_04505</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="3"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR07"/>
    <dbReference type="PaxDb" id="5476-C4YR07"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04505"/>
    <dbReference type="HOGENOM" id="CLU_032087_4_2_1"/>
    <dbReference type="OMA" id="FAINKPC"/>
    <dbReference type="OrthoDB" id="9995526at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767:SF2">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE TRUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="TRNA-PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase II N-terminal" evidence="7">
        <location>
            <begin position="60"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ46160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="386" mass="43430" checksum="71F1A260DD745F56" modified="2009-07-28" version="1">MNGVFAVYKPSGITSAKFIERIQNKFTKSEVFAKDLQEMKDKIRSDLSRDRKWKPQKIEKKIASTKVKIGHGGTLDPLASGILVVGVGLGTKKLQYYLAECQKTYETKALLGISTTTGDSEGEIVSKNKIDHITSELIDSTVEKFIGDIKQTPPIFSALKVNGKPLYEYARKGLPLPTNIKVRDVTVNNITVIKEDSLKTDHKFTKLESELDENGVPKEHGLKDNPTLNDSPLFFSKQYLEKAEKEGLPKKTGKPKLLADDESLPEKLPMIHFISDVSSGTYIRSLISDIGRAMESSAYMVELIRTKQSEWELGKNVFKFEDFEKDERIWGPVLKKVFEKGGAEIQDLDKEFEEMAKTVESSVTKETKESTSETIPQKRSIDEVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR16</accession>
    <name>C4YR16_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_04514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR16"/>
    <dbReference type="PaxDb" id="5476-C4YR16"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04514"/>
    <dbReference type="HOGENOM" id="CLU_019661_0_0_1"/>
    <dbReference type="OMA" id="CLIDSKA"/>
    <dbReference type="OrthoDB" id="4024489at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="790" mass="90878" checksum="5E27B5985B1C0711" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR20</accession>
    <name>C4YR20_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR20"/>
    <dbReference type="PaxDb" id="5476-C4YR20"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04518"/>
    <dbReference type="HOGENOM" id="CLU_067846_0_0_1"/>
    <dbReference type="OMA" id="FIHNIWT"/>
    <dbReference type="OrthoDB" id="306690at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061157">
        <property type="term" value="P:mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF89">
        <property type="entry name" value="YTH DOMAIN-CONTAINING FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="1">
        <location>
            <begin position="216"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="364" mass="40410" checksum="46E9A16F7BF85162" modified="2009-07-28" version="1">MFNTTDSSRNYLVIENSSANYISDKEEERYSNDNDIVHNSSNYYIPSLDDISSISTSASSHGTTFFSNNQSNSNRYGTPRSLSKLRSIESEIDNLPLIFKTNIWSNDYSVTHNKTANLFANFTLETGNVACSLNTANCDKSQLQYNDASYAVTAPQVSPIGNNPIAAAGNSSCTFESTTPSINANAAVLGSAYSPPPSCLTFRTYTGAIFTVPKTSKFFVIKSYNILDVNASFIHNIWTSTELGNRRLDKAYTELSKTNNPDVDGKIFLFFSVNSSGKFCGIAEMKSAIDFTTASNIWCEQTRWKGIFPVEWLLIKDVPNKFFQHLKIPANDYKPVTNSRDTQEIPFDIGISMLKIVSSFKSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR45</accession>
    <name>C4YR45_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysophospholipase</fullName>
            <ecNumber evidence="6">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_04544</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="6"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR45"/>
    <dbReference type="PaxDb" id="5476-C4YR45"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04544"/>
    <dbReference type="HOGENOM" id="CLU_014602_2_0_1"/>
    <dbReference type="OMA" id="FIANCRN"/>
    <dbReference type="OrthoDB" id="4084751at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000069">
        <property type="entry name" value="Lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF56">
        <property type="entry name" value="MEIOTIC PHOSPHOLIPASE SPO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLA2c" evidence="8">
        <location>
            <begin position="1"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ46198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="621" mass="70233" checksum="4B6BBEA5073B9423" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR96</accession>
    <name>C4YR96_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR96"/>
    <dbReference type="PaxDb" id="5476-C4YR96"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04595"/>
    <dbReference type="HOGENOM" id="CLU_102617_1_1_1"/>
    <dbReference type="OMA" id="NKGVFQG"/>
    <dbReference type="OrthoDB" id="2348401at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007250">
        <property type="entry name" value="HSP9_HSP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28145">
        <property type="entry name" value="12 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28145:SF1">
        <property type="entry name" value="12 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04119">
        <property type="entry name" value="HSP9_HSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="168" mass="18032" checksum="FC906D654DA63CFD" modified="2009-07-28" version="1">MATFAPLSKNNINRVNFSNRGKFFESCFFSTYTINPIENCKMSDAGRKNISTKINEAITPESEKSTLEKGKEQVTSTLDKAVGSNVPDNQKSFTQTVADSVQQGSDNAKADLKKQSEQAEGEAKTLAETAQEYVEVAKTEIGKAAEYVSGVVTGATEGAKTGADSTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRB9</accession>
    <name>C4YRB9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRB9"/>
    <dbReference type="PaxDb" id="5476-C4YRB9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04618"/>
    <dbReference type="HOGENOM" id="CLU_083055_0_0_1"/>
    <dbReference type="OMA" id="MEAKELW"/>
    <dbReference type="OrthoDB" id="4080456at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="194"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="292" mass="32824" checksum="B173C04E1099EC29" modified="2009-07-28" version="1">MNCKSLTMSKQQPCHSNPTKTHIQKNSRKVQRGGARGLGGGNRISQDKETQRETSINGNDAKPIPIPSNYRYDEHSMEAKELWSLVPVNSKYSNRMGSIPNQKFPINEVFAIKALEFFQGDVYKVVELISELSSSPISSNKQSKQFNEKRQPFDVKINKSSSPSSTLEYQSDSVSFNSDDEQQLFNKYLKTGTVDFHGFTVVEAMKLVPLILNHWWNQELIHRQSIGQLQKFGNSASLGSVLIITGRGIHSTGGISTIKASVNRYLINNNYIFNQPTSGSFEITGKRMNNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRC1</accession>
    <name>C4YRC1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRC1"/>
    <dbReference type="PaxDb" id="5476-C4YRC1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04620"/>
    <dbReference type="HOGENOM" id="CLU_059298_1_0_1"/>
    <dbReference type="OMA" id="SWKPAYL"/>
    <dbReference type="OrthoDB" id="2157866at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd13298">
        <property type="entry name" value="PH1_PH_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13299">
        <property type="entry name" value="PH2_PH_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF8">
        <property type="entry name" value="PROTEIN OPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="64"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="326"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="449" mass="51774" checksum="3603979ABE9BF01D" modified="2009-07-28" version="1">MVDRLETTGPVTTTMTTTTIASPQPQPLQNSTIINASPRSDVNKIHSRTSTIDTSATSTIDNNKLLISTVLYKRSRHTRQWKKKWVVLRKCQLSYYKDSKEYKPLKVYHGEDLLSFSIIPDHTKNHFALYTSNKVLHFRAPDETTFHQWVDTLNEYFSSQDNEDDDTQLLDQQQQKEEEEEEDSLNKEEPRVSDADPSPEEDHDSQVSSPPANNQQTLPIHSIQNKQQAQVRRSTSLTDSINTSTEFSDCSSEAWSTIDSPITPGNAVNMNNGSSLFNTLDVPNEEDERRRIEPSLSSHPSQPPPPIESTKNKPQSSTPNTDLVESVIEQGYMTVLKKKYNRNLTKRVYLVLTNVNLKVYKTQEDYRTDSQQQQQQQSFELIYKNYPINDILDIIELDPMTSKYQWCLLIITPLKRIRFCCHDEEDMMKWFSALKAVVVTQKKKQKEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRE4</accession>
    <name>C4YRE4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_04643</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRE4"/>
    <dbReference type="PaxDb" id="5476-C4YRE4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04643"/>
    <dbReference type="HOGENOM" id="CLU_010407_0_0_1"/>
    <dbReference type="OMA" id="IRTHSEY"/>
    <dbReference type="OrthoDB" id="129353at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17745">
        <property type="entry name" value="BRCT_p53bp1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17724">
        <property type="entry name" value="BRCT_p53bp1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047249">
        <property type="entry name" value="BRCT_p53bp1-like_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047250">
        <property type="entry name" value="BRCT_p53bp1-like_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013914">
        <property type="entry name" value="Rad9_Rad53-bd_dom_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047252">
        <property type="entry name" value="TP53BP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321:SF3">
        <property type="entry name" value="TP53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321">
        <property type="entry name" value="TUMOR SUPPRESSOR P53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08605">
        <property type="entry name" value="Rad9_Rad53_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="5">
        <location>
            <begin position="1050"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="323"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="419"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="501"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="346"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="563"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="588"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ46297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1177" mass="133812" checksum="61A669F69AE15313" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRM9</accession>
    <name>C4YRM9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CAF1B/HIR1 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_04731</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRM9"/>
    <dbReference type="PaxDb" id="5476-C4YRM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04731"/>
    <dbReference type="HOGENOM" id="CLU_010127_0_0_1"/>
    <dbReference type="OMA" id="QIYWHES"/>
    <dbReference type="OrthoDB" id="71227at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Cac2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:003023">
        <property type="entry name" value="Cac2p"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045145">
        <property type="entry name" value="PTHR15271"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271:SF4">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="1"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="128"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="176"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="409"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="424"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ46382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="460" mass="51092" checksum="B539333673565537" modified="2009-07-28" version="1">MEATILTVHWHNDNQPIYSVDFQPEQPGLVNSSPTKSAESTRLATGGGDNNIRIWKLTSSNSVEYMSTLQKHSQAVNAVRFNPRGDILASAGDDGTLLLWKKSENIIKTLESEEDEDLKESWQVVGTIRSSTAEIMDICWSPNGEQIVTGSMDNILRVYQLEFSPGKITGTLIRSFSDHTHYIQGVFWDPLNKFIVSQSADRSLNVYQISPSESNSIEINFRHKFQKFGNLYLYYPETLQSFFRRLAFSPDGSILVTPAGLEETSSNETLNNVLYIYSRASLFTSPIYKITGLSKPAIAVSFNPVKYKVDGPSTLKLPYKLVFAVATQDGVVLYSTQDNFKPLGLVSNLHYSSITDLKWTVDGSRVIISSTDGFCSTINFPGSAFGERYIGVPHDNDILSGEILQAKTESKAEPVASSEIANEKSPNSKSDNSKTSTPTIDLFFDKNQKVKKRITPTLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRR9</accession>
    <name>C4YRR9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRR9"/>
    <dbReference type="PaxDb" id="5476-C4YRR9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04776"/>
    <dbReference type="HOGENOM" id="CLU_2072814_0_0_1"/>
    <dbReference type="OMA" id="DSWLRND"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="121" mass="14414" checksum="3616B8C78884F7FB" modified="2009-07-28" version="1">MQDTREEEEGQEKHGLSFHQTQNNSVQIIDSWLRNDIKKKDKKKRKKKKPDVQSYLRMLTNDQKLNLELIRLGAVIPSFLCNQSEIIMSLVKYVCFYYKCHVCMLYVIQRFLLSFIILSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS42</accession>
    <name>C4YS42_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_04900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS42"/>
    <dbReference type="PaxDb" id="5476-C4YS42"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04900"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_9_1"/>
    <dbReference type="OMA" id="GPDEVMW"/>
    <dbReference type="OrthoDB" id="10261640at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000630">
        <property type="entry name" value="Ribosome assembly protein SQT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF8">
        <property type="entry name" value="ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="62"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ46545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="415" mass="45779" checksum="A23A8BD5E213E312" modified="2009-07-28" version="1">MSHQQEDVVDDTQEEYINVNEVAEEVADDDQAPPDEEDEEMELDDEHETLEIDMSNNSWTYFDKHTDSIFTIFSHPKLPMVLTGGGDNTAYLWTTHTQPPRFVGEITGHKESVISGGFTADGKFVVTADMNGLIQVFKATKGGEQWVKFGELDEVEEVLFVTVHPTLPFFAFGATDGSIWVYQIDESSKSLVQIISGFSHTLECNGAVFIQGKDENDLTLVSISEDGTVVNWNCFTGQVNYKLQPHDDFKGVESPWVTVKVHGNLVAIGGRDGQLSIVNNDTGKIVHTLKTLDNVDDIAELSIEALSWCESKNINLLAVGLVSGDVLLFDTQQWRLRKNLKVDDAITKLQFVGETPILVGSSMDGKIYKWDARTGEELFAGVGHNMGVLDFAILDGGKKLVTAGDEGVSLVFVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS52</accession>
    <name>C4YS52_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PPPDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_04911</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS52"/>
    <dbReference type="SMR" id="C4YS52"/>
    <dbReference type="PaxDb" id="5476-C4YS52"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04911"/>
    <dbReference type="HOGENOM" id="CLU_101028_0_1_1"/>
    <dbReference type="OMA" id="HLMLGKQ"/>
    <dbReference type="OrthoDB" id="21221at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070646">
        <property type="term" value="P:protein modification by small protein removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="4">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ46556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="153" mass="17384" checksum="303DA3F9DECE2CBD" modified="2010-10-05" version="1">MTEDTVQVYVYDLSQGLARVYSPMLLGISIDAIYHTSVVIRNKEYYLDQGIKVNSPPGHTKYGTPIEVLEIGTTGVDDELLNDFINELKNHDEMKYHAVNYNLFTNNCNHFTDVVIDFLCGKNLEDRILKLPDTVLNTPNGQLLQQMLGQNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS60</accession>
    <name>C4YS60_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_04919</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS60"/>
    <dbReference type="PaxDb" id="5476-C4YS60"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04919"/>
    <dbReference type="HOGENOM" id="CLU_008455_11_5_1"/>
    <dbReference type="OMA" id="TIYMAIC"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF48">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="516"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="540"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="134"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
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        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ46563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="581" mass="64606" checksum="322E4FE532CA11FD" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS74</accession>
    <name>C4YS74_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">JAB1/MPN/MOV34 metalloenzyme domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">CAWG_04933</name>
    </gene>
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        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
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                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="26227" checksum="6BB5C61E9EE4776B" modified="2010-10-05" version="1">MIVELHSDVLLHVSDLFARGVENKLGLLLGYGLDDRLVVVKPIELAQVDPQYLEKRYSLFKDVYPNLSIVGVYEIGGNNPDRANILDIPAGRILYVSVDHNIQFKSFIDGDLVKTVIESSETEVIATKTIDTNKEYTKGRPKDELTVAEFNQNMVNTLTKLYERLTKILETKGMDKEIVEIANALRCYKHVKQSTDMKLQAAELALITEQIAELERTKIGIAKKILVKEPGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS81</accession>
    <name>C4YS81_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">CAWG_04940</name>
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    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
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                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
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                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
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                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
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                <person name="Quail M.A."/>
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                <person name="Santos M.C."/>
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                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
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                <person name="Zeng Q."/>
                <person name="Berman J."/>
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                <person name="Gow N.A."/>
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            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04940"/>
    <dbReference type="HOGENOM" id="CLU_2312711_0_0_1"/>
    <dbReference type="OrthoDB" id="4027274at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="104" mass="12121" checksum="AF43FA170A0D57F1" modified="2009-07-28" version="1">MTRINIFKKLKLLEKSIYDDLLNKIKELNLDDETMEKIEQFSVKPNRKAPVTPLEKQCGKLTKKGEKCKIAICYKKTCWAHLTKEEYGVLNMNKKDCGECMHIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS90</accession>
    <name>C4YS90_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_04949</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="LEEEWIQ"/>
    <dbReference type="OrthoDB" id="4021459at2759"/>
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        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005668036" evidence="3">
        <location>
            <begin position="21"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="701"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="746"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ46593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="811" mass="94580" checksum="06CC6AA04DD7F7D5" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSF7</accession>
    <name>C4YSF7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH:ubiquinone reductase (non-electrogenic)</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_05022</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
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                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a quinone + NADH + H(+) = a quinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46160"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a ubiquinone + NADH + H(+) = a ubiquinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:23152"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.9" evidence="3"/>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YSF7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05022"/>
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        <property type="component" value="Chromosome 6"/>
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        <property type="term" value="F:NADH dehydrogenase (quinone) (non-electrogenic) activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0015980">
        <property type="term" value="P:energy derivation by oxidation of organic compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
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    <dbReference type="PANTHER" id="PTHR43706:SF47">
        <property type="entry name" value="EXTERNAL NADH-UBIQUINONE OXIDOREDUCTASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
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    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
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            <end position="505"/>
        </location>
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            <end position="618"/>
        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ46660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="622" mass="70572" checksum="AB736D7F3E597155" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSM6</accession>
    <name>C4YSM6_CANAW</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="563" mass="63791" checksum="9D479E5BC21D5090" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSY5</accession>
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        <recommendedName>
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    </protein>
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            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
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                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
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                <person name="Zeng Q."/>
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                <person name="Lorenz M.C."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021935">
        <property type="entry name" value="SGSM1/2_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF502">
        <property type="entry name" value="SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12068">
        <property type="entry name" value="PH_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="387"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="461"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="725"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="475"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="730"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ47121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="776" mass="90447" checksum="8B7F5F6F9AB0648D" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT03</accession>
    <name>C4YT03_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_05700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT03"/>
    <dbReference type="PaxDb" id="5476-C4YT03"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05700"/>
    <dbReference type="HOGENOM" id="CLU_073356_1_0_1"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ47139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="170" mass="19584" checksum="4C603383892CBD35" modified="2009-07-28" version="1">MEMGIHELSASFESLKNLYRLSLMGNQLRNVNSVKLPVSSLEVLNVRQCNLRMISPFLVSMLEEKNQNANLRVEATGNLNVNINDVRKVMKAIKGFSLDLNRFDETLREIAQKSSRLCCIFETFDPYFETPQSSETEEVVSDYDSDDLYSGSVFYSDEEDNAYNNKRRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT93</accession>
    <name>C4YT93_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT93"/>
    <dbReference type="PaxDb" id="5476-C4YT93"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05379"/>
    <dbReference type="HOGENOM" id="CLU_072858_0_0_1"/>
    <dbReference type="OMA" id="IAMDCES"/>
    <dbReference type="OrthoDB" id="5953249at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="1">
        <location>
            <begin position="104"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="313" mass="35861" checksum="1539CCFCE801A39E" modified="2010-10-05" version="1">MFKSSPFKTFVRTKVEYVKNTKFKPVKYSKFIPKTYTFHPYEPAKKVEITSSLQQLKNQVKSGDEITKEQYLNSPHFKFQEGKEGNSLAYLRQCISLINSGKPLIAMDCESYERNHSQVTEIGVAIMTYRKSTVPQIKTIHVVVKEHFKKRNTLYVPDKKDQFMGGSSFVMTENKTRIFLQKLLDKYVDEMDGVFVGHQVSSELKYFKSIGVNCKADVHTIDTMKLMQLSKSGGNSLWATLRELEIPYGHLHNAGNDAYFTLLAALSLCDPIVRIDKNLDIYMDSPYKGKKAAHDDSSTYFVVEDIEKVIESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTJ2</accession>
    <name>C4YTJ2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Double-strand break repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CAWG_05485</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16 18">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTJ2"/>
    <dbReference type="PaxDb" id="5476-C4YTJ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05485"/>
    <dbReference type="HOGENOM" id="CLU_009535_3_0_1"/>
    <dbReference type="OMA" id="QNHTGHT"/>
    <dbReference type="OrthoDB" id="30417at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.110:FF:000004">
        <property type="entry name" value="Double-strand break repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000011">
        <property type="entry name" value="Double-strand break repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00583">
        <property type="entry name" value="mre11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000882">
        <property type="entry name" value="DSB_repair_MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 16 18" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16 18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 16 18" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 16 18" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 16 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 16 18" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 16 18" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16 18" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14 16 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="20">
        <location>
            <begin position="294"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="544"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="569"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="596"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="650"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000882-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EEQ46933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="683" mass="77339" checksum="DBFB45F956B370AE" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTQ1</accession>
    <name>C4YTQ1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rhomboid-type serine protease 2</fullName>
            <ecNumber evidence="4">3.4.21.105</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Rhomboid protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_05546</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Probable rhomboid-type serine protease that catalyzes intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">cis-Golgi network membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="4"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTQ1"/>
    <dbReference type="PaxDb" id="5476-C4YTQ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05546"/>
    <dbReference type="HOGENOM" id="CLU_071084_0_0_1"/>
    <dbReference type="OMA" id="NTYPIVH"/>
    <dbReference type="OrthoDB" id="10257275at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF1">
        <property type="entry name" value="RHOMBOID PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="14">
        <location>
            <begin position="60"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ46992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="284" mass="31719" checksum="9656691B2AED972D" modified="2009-07-28" version="1">MINFDEFPPKYDPSLRPPALTTGLIVFTFMLCVIKSVTSYTFESLILYPRAPLDLNLNSISLYSLFHVNFFHWICNIFTLATPLAVFETRNGTIHTGVTLNLLTVIAALQYCIVGLIFYPNTGVIGLSGIAFSLMSYMAYHESKFRPIMHTFHLSNSLEIKLYTLYVPFVVAIVFMILFPSSSLPGHLFGITTGYLLSYGYIDKLYPPSKVITTIENKLSSLINFLELIVTFYKEEESLVTRGSVGYKPLFNQDIEHGAANAASHGSSAFVGETRVLGTRESTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTU1</accession>
    <name>C4YTU1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTU1"/>
    <dbReference type="PaxDb" id="5476-C4YTU1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05586"/>
    <dbReference type="HOGENOM" id="CLU_144908_0_0_1"/>
    <dbReference type="OMA" id="PNGAYYN"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ47032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="160" mass="18445" checksum="79441D93E29C6302" modified="2009-07-28" version="1">MLLPESIDTQSLIKRIVYYNNYDRSGWWRWRWLLWLLILIPIFAMIFLLSRRRRQNKVVAYNNPGPQPNGAYYNNNNQYQGGYQGGYQGNNDLPPQATPGYIPPAYPETSQQQGSYGGGYSSQQQNGYNPQQQQQQQSGTYNSEEFSRPEGPPPAHTKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTW8</accession>
    <name>C4YTW8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_05614</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTW8"/>
    <dbReference type="SMR" id="C4YTW8"/>
    <dbReference type="PaxDb" id="5476-C4YTW8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05614"/>
    <dbReference type="HOGENOM" id="CLU_000445_3_1_1"/>
    <dbReference type="OMA" id="QLIHLMG"/>
    <dbReference type="OrthoDB" id="10266508at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097308">
        <property type="term" value="P:cellular response to farnesol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900445">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06225">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000001">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000015">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1530">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158472">
        <property type="entry name" value="HAMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="63"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="157"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="249"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="341"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="433"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="507"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="14">
        <location>
            <begin position="875"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1010"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1023"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1068"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="11">
        <location>
            <position position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEQ47059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1081" mass="118932" checksum="260EE960E55CACF3" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTX3</accession>
    <name>C4YTX3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translation initiation factor IF-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_05619</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTX3"/>
    <dbReference type="PaxDb" id="5476-C4YTX3"/>
    <dbReference type="HOGENOM" id="CLU_006301_5_2_1"/>
    <dbReference type="OrthoDB" id="361630at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:mitochondrial translation"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="mtIF2_IVc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial translation initiation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Elongation factor G-like" evidence="12">
        <location>
            <begin position="51"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Translation initiation factor IF- 2" evidence="11">
        <location>
            <begin position="187"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ47064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="404" mass="44977" checksum="403BCADD7F2DCE32" modified="2009-07-28" version="1">MHGVDIEDYGGETQTVQVSGKTGLNMDKLEEAVITLSELCDFKAEPKGIHAEGWIIESEVVKGMGNVATVLVRRGSLKNGDIIVAGKTFCKIRGMKDENNKMVKIAGPSTPVRIWGWKDLPDSGDQILQANSEQIAKKVIDYRITRSQEIQATRDIEDINVKRLEEIKEAERLEKIAELKKAGLDASTLEKAEQDKKTIKCNYIVRSDVFGSAEAIKESIDGLGNEEVESVVISHEAGPPTDSDIELAKTFGATIFCFNMKVPKPIAVRADKEKVKVKEHNIIYRLIEDVTDELSFHLKPRVEIKTLGEVDIKDVFVVTVKKQKVKIAGCKVTTGSIKSSSQVKVLRNGQEVYCGKLSSLKHVKDDITEATKGKDCGIAFEKWQDFEAGDKIQVYEEILHKRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTZ2</accession>
    <name>C4YTZ2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin biosynthesis protein CHS6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_05640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTZ2"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05640"/>
    <dbReference type="HOGENOM" id="CLU_014275_0_0_1"/>
    <dbReference type="OMA" id="RKSTWGR"/>
    <dbReference type="OrthoDB" id="434695at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:002277">
        <property type="entry name" value="Chitin biosynthesis effector, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015374">
        <property type="entry name" value="ChAPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09295">
        <property type="entry name" value="ChAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ47083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="761" mass="87515" checksum="C7B3AF07720FE0E1" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>C5K457</accession>
    <name>C5K457_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_06160</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG670284">
        <property type="protein sequence ID" value="EEQ43139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C5K457"/>
    <dbReference type="PaxDb" id="5476-C5K457"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06160"/>
    <dbReference type="HOGENOM" id="CLU_183174_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Unplaced Supercontig 1.16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056915">
        <property type="entry name" value="Ig_TR130_2nd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24966">
        <property type="entry name" value="Ig_TR130_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs130 second Ig-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="100" mass="11789" checksum="7D0113F7737F9C82" modified="2009-07-28" version="1">MSRTRHCNNETSQLHIFKKKHTQTHTQLSVNFSTQNNSKSVKINEQQFNKIHIPYIIEKQDESISLRQKATMKHCKFISKPSYSFHPIFLETTFLGSIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCQ2</accession>
    <name>C4YCQ2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_00286</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCQ2"/>
    <dbReference type="PaxDb" id="5476-C4YCQ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00286"/>
    <dbReference type="HOGENOM" id="CLU_927848_0_0_1"/>
    <dbReference type="OMA" id="NAGTWED"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051938">
        <property type="entry name" value="Apopto_cytoskel_mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145:SF3">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="50"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ42088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="316" mass="37386" checksum="39E0FCACCFA1BEB7" modified="2009-07-28" version="1">MLSLLQKRIAVTINSNLAISKAHYATASQEPIDHHKRFQLHEWPKSAKPSAYEIFGLTSKDMGMSTLELNKVLKRKYLALVKIYHPDTSLSIQYKGGEMTAEMKRKRFDMIQEAYDILKNPRRRTAYNRYQTTSWDQQGHYSGNGGQWSKENFEAYRRAHAHRTRYNFENDEQFWSASTWQDYYQMKYNRPPPTKEELEKNKYKILFGVIAVGVLGFGLQIMNAIDKTNQYLLETHRLNMKSMKDLNESYDNYGEGYSDADKLRRFLINRRSTMKSKREEEGVEKEPEPSDHELLTKFARKRVDIWDREEGNNEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD50</accession>
    <name>C4YD50_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_00440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for vacuolar assembly and vacuolar traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the VPS41 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD50"/>
    <dbReference type="PaxDb" id="5476-C4YD50"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00440"/>
    <dbReference type="HOGENOM" id="CLU_001285_2_1_1"/>
    <dbReference type="OMA" id="PQLVWQD"/>
    <dbReference type="OrthoDB" id="244107at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000933">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016902">
        <property type="entry name" value="Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028921">
        <property type="entry name" value="VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Vps41 beta-propeller" evidence="7">
        <location>
            <begin position="75"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="5">
        <location>
            <begin position="674"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR028921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ42236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="961" mass="110130" checksum="4F460248F342DB87" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDJ2</accession>
    <name>C4YDJ2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_00587</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDJ2"/>
    <dbReference type="PaxDb" id="5476-C4YDJ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00587"/>
    <dbReference type="HOGENOM" id="CLU_013694_4_0_1"/>
    <dbReference type="OMA" id="TIAMDAC"/>
    <dbReference type="OrthoDB" id="1284551at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YE40"/>
    <dbReference type="PaxDb" id="5476-C4YE40"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00793"/>
    <dbReference type="HOGENOM" id="CLU_2133158_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="113" mass="13762" checksum="A7AC606533B387D2" modified="2010-10-05" version="1">MLLLLVKNFNINIPFNFLEIVPFFSFFCNLYKFLVCFTLSSISTPRSYIKSCINWLRNCYYYYHIKREIKNISSPHHYHNQEFFFTYSLNHSTLIISLTKKSTFFFSFYFGHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEF6</accession>
    <name>C4YEF6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_00913</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEF6"/>
    <dbReference type="PaxDb" id="5476-C4YEF6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00913"/>
    <dbReference type="HOGENOM" id="CLU_135723_1_1_1"/>
    <dbReference type="OMA" id="MISITKV"/>
    <dbReference type="OrthoDB" id="10265903at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_bL36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052143">
        <property type="entry name" value="Mitoribosomal_bL36m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_bL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_bL36_sp"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46909">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46909:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL36M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="Ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ42692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="123" mass="14391" checksum="1A2AC0AC04471991" modified="2009-07-28" version="1">MCVYIGTKKLSKIFFFREFCQRIIFSIILSITYNRLTIHHIIMISITKVISQQFKSSNITKNLFNATPRIINPITTGSLYQPIRGFKVRTSVKCMCKDCYLVKRKGRVYVYCKSNGKHKQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF29</accession>
    <name>C4YF29_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase component FKS1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_01140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF29"/>
    <dbReference type="PaxDb" id="5476-C4YF29"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01140"/>
    <dbReference type="HOGENOM" id="CLU_000844_1_0_1"/>
    <dbReference type="OMA" id="DINETFW"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056261">
        <property type="entry name" value="FKS1-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23605">
        <property type="entry name" value="FKS1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="495"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="3">
        <location>
            <begin position="112"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ42915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="527" mass="61281" checksum="59C270A73009BE6D" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF48</accession>
    <name>C4YF48_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Importin-95</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Karyopherin-95</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_01159</name>
    </gene>
    <organism evidence="12 13">
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        </source>
    </evidence>
    <sequence length="316" mass="35445" checksum="EB03DB9F559B224C" modified="2009-07-28" version="1">MALCSPTFPSTSAVVAGAATKRGCSTFNSLYTTPNKRICLNNKISAFGGIGFKGFYNSSLSSEEEDSESDSDNGAQSPFEAIQVRRKLIPTRKSSVVLAVTGSETEIENLDCSTVHYTDSQDDGNCDNNNSIPIADRNARTRCFEYLIGAIDEAWARYCDATTSFEDDVFGSNKLGNSTTKRAYNGKLNDNNDDNEDYDDDDDDDDEDDSADETFDNNTDITDYSDFPHQQTIASTQASSKPDQSSCQLQDLKVRLTKAKYYLQELVDSNDYREIELFWKRWDMIKYSTIELVEDDDDDEIIESTIEELENGRLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG17</accession>
    <name>C4YG17_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_00132</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YG17"/>
    <dbReference type="PaxDb" id="5476-C4YG17"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00132"/>
    <dbReference type="HOGENOM" id="CLU_002472_1_0_1"/>
    <dbReference type="OMA" id="TPMMAQY"/>
    <dbReference type="OrthoDB" id="10252754at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000019">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000006">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000771">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 11 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 11 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="15">
        <location>
            <begin position="1041"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="785"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="181"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEQ41941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1214" mass="136846" checksum="F7B733FF752419E9" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG30</accession>
    <name>C4YG30_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial group I intron splicing factor CCM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_00146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YG30"/>
    <dbReference type="PaxDb" id="5476-C4YG30"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00146"/>
    <dbReference type="HOGENOM" id="CLU_272246_0_0_1"/>
    <dbReference type="OMA" id="IFITSIM"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051114">
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        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1-RELATED"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ41954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1174" mass="138324" checksum="B0669DBB664E364E" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG41</accession>
    <name>C4YG41_CANAW</name>
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        </submittedName>
    </protein>
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        <name type="common">Yeast</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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            <taxon>Candida</taxon>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
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                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
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                <person name="Skrzypek M.S."/>
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                <person name="Staggs R."/>
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                <person name="Lorenz M.C."/>
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    </dbReference>
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        </location>
    </feature>
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        <location>
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            <end position="332"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG50</accession>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Lin M.F."/>
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                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
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                <person name="Hube B."/>
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                <person name="Kodira C."/>
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                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
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                <person name="Sherlock G."/>
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                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
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                <person name="Staggs R."/>
                <person name="Stansfield I."/>
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                <person name="Zeng Q."/>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0004402">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916:SF26">
        <property type="entry name" value="CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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    </feature>
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        </location>
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        </location>
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        <location>
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            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="888"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="917"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="931"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ41974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="944" mass="107784" checksum="79467D6B451DE3B1" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG66</accession>
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        <submittedName>
            <fullName evidence="8">Membrane protein TMS1</fullName>
        </submittedName>
    </protein>
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    <organism evidence="8 9">
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
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                <person name="Brunke S."/>
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                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YG66"/>
    <dbReference type="PaxDb" id="5476-C4YG66"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00184"/>
    <dbReference type="HOGENOM" id="CLU_029574_2_0_1"/>
    <dbReference type="OMA" id="DKHCNPL"/>
    <dbReference type="OrthoDB" id="5963193at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946457" evidence="7">
        <location>
            <begin position="17"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ41990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="511" mass="56326" checksum="E936433A03C32772" modified="2009-07-28" version="1">MGAAISLPLMPITSLASCCGAAACSAFCTSIGGTFKSSIMTRITYAILLLINSLLSWIALSPFIINKIEKATFGFINISCGPDGSQCISFTSVHRINFALGILHLILASLLVNVKSTANPRAIIQNGCWKLKIFAWITFIFINFVIIPDSFFIFYGNHIAIIFSTIFLGIGLILLVDFAHAWAEKCLEKIEMEELTGEGDASFWKKLLIGGTLAMYIGSIILTILMYWFFTGSGCSMNKTAISLNLVFSIIISAMSIHNTVQEYNPSAGLAQSSMVVFYCTYLVMSAVASEPDDKFCNPLIRSRGTRTASVILGAFFTFIAVAYTTTRAAANSAFSSESSPNFVATGITTTSQQPSARNEMRYQAIKQAVDEGSLPESALNQLDLYEDEDVNDEEIQSVQYNYSLFHIIFFLATQYVATLLTINVKQDDYGDFVPVGRTYFASWVKIISSWVCFVLYGWSLLAPVIWPDRFGIQVKPNDFFINVCFYLGSRLVGGEGGYCQLLGKVEKYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGB5</accession>
    <name>C4YGB5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGB5"/>
    <dbReference type="PaxDb" id="5476-C4YGB5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00236"/>
    <dbReference type="HOGENOM" id="CLU_075354_0_0_1"/>
    <dbReference type="OMA" id="ARFKNCI"/>
    <dbReference type="OrthoDB" id="4001493at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946458" evidence="1">
        <location>
            <begin position="24"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="239" mass="26726" checksum="9A0AD1DEDC47EF29" modified="2009-07-28" version="1">MKIVIFTIITTVLGLEILPYVEPTTIDTELLLTYKSNMVQVDKYNDIKTSELDNNKVVQVISTSSYIFSDEIVDNIFNQQSKPAKSSTKYIEVSYEDAISVSQSQIWARFKNCIPNHSQNRATYKQGWSIDLGSGGNARLDFSNFLGGIGPAFKNELVGSFGIGGSLTCEINAGNHLQIAVLVKSFTVDKVKQREVKFTKFGLKNSKKKGWSFFPKFVLFDKKSLEIACITDPKFLDCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGB8</accession>
    <name>C4YGB8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2-oxoglutarate reductase</fullName>
            <ecNumber evidence="4">1.1.1.399</ecNumber>
            <ecNumber evidence="5">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_00239</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.399" evidence="4"/>
    <dbReference type="EC" id="1.1.1.95" evidence="5"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGB8"/>
    <dbReference type="SMR" id="C4YGB8"/>
    <dbReference type="PaxDb" id="5476-C4YGB8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00239"/>
    <dbReference type="HOGENOM" id="CLU_019796_9_2_1"/>
    <dbReference type="OMA" id="SKGCWEV"/>
    <dbReference type="OrthoDB" id="1621027at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061759">
        <property type="term" value="F:2-oxoglutarate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04901">
        <property type="entry name" value="ACT_3PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12176">
        <property type="entry name" value="PGDH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000036">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000041">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008759">
        <property type="entry name" value="PRK11790.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH01</accession>
    <name>C4YH01_CANAW</name>
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        <recommendedName>
            <fullName evidence="11">Bas1p</fullName>
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        <name evidence="9" type="ORF">CAWG_03342</name>
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        <name type="scientific">Candida albicans (strain WO-1)</name>
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            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
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                <person name="Sherlock G."/>
                <person name="Shah P."/>
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                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
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                <person name="Heitman J."/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="737" mass="84381" checksum="E5303261D8594A7B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH26</accession>
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        <recommendedName>
            <fullName evidence="3">Mrp8p</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">CAWG_03367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
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                <person name="Cuomo C.A."/>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
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        <property type="component" value="Chromosome 4"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_MRP8_mit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ45058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="23398" checksum="A2E3D8FBAD6609AA" modified="2010-10-05" version="1">MSELSKLNEAKAKVAELEALVKKQASVMVQARQKLVDVELRNKKNQAAQNINQQPALDLTDYVNNDDIVQLVTELQTQLDALEARTMRRTYNATVQGDDEKLAPITNKDGDLPDFALPVTLKEFKSLEKIDLIRLGVFYEIILPDGEEIDHALQQTNSKEAILDINKKKDIIELSKNFDEDQANEIYDELARYFGIKHRRNSDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH83</accession>
    <name>C4YH83_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RRM Nup35-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_03427</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YH83"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03427"/>
    <dbReference type="HOGENOM" id="CLU_036683_0_0_1"/>
    <dbReference type="OMA" id="WIKLTYD"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nuclear pore nuclear basket"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="RRM_NUP35_dom"/>
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    <dbReference type="PANTHER" id="PTHR21527">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527:SF6">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM_NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6 8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM Nup35-type" evidence="10">
        <location>
            <begin position="316"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="92"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="482"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="540"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="26"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
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            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
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            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="540"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU00804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ45115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="590" mass="65073" checksum="29DBE66D87F3C5F9" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHA0</accession>
    <name>C4YHA0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_03445</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
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                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03445"/>
    <dbReference type="HOGENOM" id="CLU_003639_3_1_1"/>
    <dbReference type="OMA" id="QWKFLGR"/>
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    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="6">
        <location>
            <begin position="298"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="7">
        <location>
            <begin position="355"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="430"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ45132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="543" mass="63920" checksum="31FFC03B64DD62E3" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHG0</accession>
    <name>C4YHG0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_03506</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHG0"/>
    <dbReference type="PaxDb" id="5476-C4YHG0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03506"/>
    <dbReference type="HOGENOM" id="CLU_016552_4_0_1"/>
    <dbReference type="OMA" id="NKYELNF"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="7">
        <location>
            <begin position="124"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="417"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="444"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ45192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="522" mass="58964" checksum="6ED93004B3131436" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHK0</accession>
    <name>C4YHK0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_03547</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHK0"/>
    <dbReference type="SMR" id="C4YHK0"/>
    <dbReference type="PaxDb" id="5476-C4YHK0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03547"/>
    <dbReference type="HOGENOM" id="CLU_141397_0_1_1"/>
    <dbReference type="OMA" id="MAAWNQV"/>
    <dbReference type="OrthoDB" id="7813104at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000001">
        <property type="entry name" value="mitochondrial import inner membrane translocase subunit TIM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="15">
        <location>
            <begin position="39"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEQ45232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="109" mass="12174" checksum="6B08E88B2EF2E928" modified="2009-07-28" version="1">MAFWNSSSSSSSSSGQTDSSSTSSPASLRSQQIKQDLQNQISQELAAANATELVRTITENCFDKCILIPKDTLSPTELQCISQCREKYMRSWNVISKAYIGRIQQEQHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHR1</accession>
    <name>C4YHR1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Pyruvate decarboxylase isozyme 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_03610</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>pyruvate + H(+) = acetaldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:45484"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHR1"/>
    <dbReference type="PaxDb" id="5476-C4YHR1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03610"/>
    <dbReference type="HOGENOM" id="CLU_013748_0_2_1"/>
    <dbReference type="OMA" id="EARFPNN"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000018">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="15">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="13">
        <location>
            <begin position="209"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="14">
        <location>
            <begin position="427"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <label>1</label>
            <note>substrate; ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <label>1</label>
            <note>substrate; ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <label>2</label>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="507"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <label>1</label>
            <note>substrate; ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEQ45293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="599" mass="65133" checksum="5C76DFED202C21EC" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHX2</accession>
    <name>C4YHX2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_03675</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YHX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03675"/>
    <dbReference type="HOGENOM" id="CLU_002593_0_0_1"/>
    <dbReference type="OMA" id="HAQQNYE"/>
    <dbReference type="OrthoDB" id="343070at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057974">
        <property type="entry name" value="NUA/TPR/MLP1-2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012929">
        <property type="entry name" value="Nucleoprot-TPR/MLP1-2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898:SF2">
        <property type="entry name" value="NUCLEOPROTEIN TPR"/>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
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</entry>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI35</accession>
    <name>C4YI35_CANAW</name>
    <protein>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
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                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI35"/>
    <dbReference type="PaxDb" id="5476-C4YI35"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03743"/>
    <dbReference type="HOGENOM" id="CLU_007127_3_1_1"/>
    <dbReference type="OMA" id="DVCFPDY"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="735"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="770"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="58"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="135"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="320"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ45417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="797" mass="90615" checksum="5F9B1DB5F4559746" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI66</accession>
    <name>C4YI66_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="6">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_03775</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Lipid-anchor</topology>
            <topology evidence="6">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI66"/>
    <dbReference type="PaxDb" id="5476-C4YI66"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03775"/>
    <dbReference type="HOGENOM" id="CLU_021855_1_2_1"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF14">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="264"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ45448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="320" mass="36357" checksum="2B224F0C1F800C5E" modified="2009-07-28" version="1">MSKRWSAKSKAISNTMHQEPSPSGYSAADDLNYRMPLAQYLECGDDNPKESVDFYGVNSYQWCGDQTFYSSGYNILVNDYKHFTKPMFFSEYGCNEVLPRNFDEVPVLYTNDMIDVFSGGLVYEFTQEPNNYGLVKVLSNGDIKVLRDFIQLKNKFDTLPELDYSYIIQSMKENAKDIHQKLTTFKTSIPKCELSYPNLDISRGVPPTIAQTLIETGVDAKRGEYVTLSNEDLTTTYKFFQESGEKLAIVNRIETMVEVDEKALENRETPQEPAEPAEPAEPAEPTEPAEPPSPPPSTPFIDFIHKLIDPFKTFCANLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIC5</accession>
    <name>C4YIC5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_04197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIC5"/>
    <dbReference type="PaxDb" id="5476-C4YIC5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04197"/>
    <dbReference type="HOGENOM" id="CLU_016174_1_1_1"/>
    <dbReference type="OMA" id="CHISDSE"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ45860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="686" mass="78132" checksum="FEAD87F749A65DF8" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIC7</accession>
    <name>C4YIC7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_04200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIC7"/>
    <dbReference type="PaxDb" id="5476-C4YIC7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04200"/>
    <dbReference type="HOGENOM" id="CLU_111640_0_0_1"/>
    <dbReference type="OMA" id="LEYRGCY"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ45862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="216" mass="24707" checksum="B938760566BA56B8" modified="2009-07-28" version="1" fragment="single">MDASSINCFFDGKEFWSRYPENSLRLFSGSKIKLDFLSLSNFSNPLTILPVVKRIKLLNTVLTSYEIPCVKKMDINLAPTGVEDQTYTFSSDLKELQIKTKRSIKVSLPPNLWKLVIGTHSSSVDFVSEELLNLKVLSLSLPNIEFFHETGIVALNLTKLVLTNCGNLSNYDELRQFHHLKHLFVENSSYPIDLFSEDSFPKLDKLEYRGCYMPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YID4</accession>
    <name>C4YID4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_04207</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-methyl-UTP(out) + UTP(in) = 5-methyl-UTP(in) + UTP(out)</text>
            <dbReference type="Rhea" id="RHEA:73523"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:63527"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YID4"/>
    <dbReference type="PaxDb" id="5476-C4YID4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04207"/>
    <dbReference type="HOGENOM" id="CLU_015166_6_0_1"/>
    <dbReference type="OMA" id="WVMYEQM"/>
    <dbReference type="OrthoDB" id="269120at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000079">
        <property type="entry name" value="Mitochondrial carrier protein RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000088">
        <property type="entry name" value="Mitochondrial carrier protein RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="76"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="196"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="305"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ45869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="399" mass="44445" checksum="31058FB4FEB8A75A" modified="2009-07-28" version="1">MTEEEKKRLQVLERDAETAYPFLASDEKSSTFKTAEDLESGINPLVSIATTNESQQKLDNVSSISTTTNEKPKPKPKPWVHFVAGGIGGTVGAVVTCPLDVVKTRLQSDVYHSMYNKIPKSGNPIIQAWQHLSETGSVLRGMYINEGASSLFKGLGPNLVGVIPARSINFFIYGATKEFLLGNFSPTNSIQGPRQEETWIHLVSGINAGFVTSTATNPIWLIKTRLQLDKSKGKNYKNSWDCFKHIIKHEGFTSLYRGLSASYLGGIESTIQWVLYEQMRMFINKRSLQIHGNDPSNKTTKDHILEWSARSGAAGLAKFMASLITYPHEVVRTRLRQAPLESTGKPKYTGLIQCFKLVIKEEGFGSMYGGLTPHLLRTVPNSIIMFGTWELVVRLLSEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIP3</accession>
    <name>C4YIP3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GPI-anchored wall transfer protein</fullName>
            <ecNumber evidence="8">2.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_04319</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PIGW family.</text>
    </comment>
    <dbReference type="EC" id="2.3.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIP3"/>
    <dbReference type="SMR" id="C4YIP3"/>
    <dbReference type="PaxDb" id="5476-C4YIP3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04319"/>
    <dbReference type="HOGENOM" id="CLU_020802_2_2_1"/>
    <dbReference type="OMA" id="GLYVMQP"/>
    <dbReference type="OrthoDB" id="15270at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017321">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 8" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ45978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="485" mass="55200" checksum="B7F15DDEEDC22EB6" modified="2009-07-28" version="1">MSSSLKQLKEQFVSDLTGGTIEEIYAVTSIALSSYLSFRLLKKSLGDLALIYDYILNVLTILASITVYSNSPSYLHYFIVIPSLVIYLVNYHVEKPSSPHRQNDTKEDKSDELLPRKQFITAYRSQMLIITNLAILAVDFPIFPRRFAKVETWGTSMMDLGVGSFVFSMGLANSRQLIKNHTDNYKFSWKSYLKTIKQNFIKSVPILVLGAIRFVSVKQLDYQEHETEYGIHWNFFFTLGFLPIVLGILDPVLNLVPRFIIGIGISIAYEVALNKTGLLKFILSSENRLESLITMNKEGIFSFIGYLCIFIIGQSFGSFVLTGYKTKNNLITISKIRISKKQHKKESSSFFSVATTQGLYLACIFYHLAFSLFISNLSFLQPISRRLANFPYVMWVVSYNATFLLCYDLIEKFIPGNLTSTVLDSINNNGLFIFLVSNLLTGFINMSINTLETSNKMAVIILIGYSLTWTLLALYLDKRKIYIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIQ6</accession>
    <name>C4YIQ6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIQ6"/>
    <dbReference type="PaxDb" id="5476-C4YIQ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04332"/>
    <dbReference type="HOGENOM" id="CLU_473256_0_0_1"/>
    <dbReference type="OMA" id="WDYETGW"/>
    <dbReference type="OrthoDB" id="5562739at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR XBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="2">
        <location>
            <begin position="233"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="552"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ45991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="577" mass="64313" checksum="343992E018667DB0" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIU3</accession>
    <name>C4YIU3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_04372</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADIP family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ46028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIU3"/>
    <dbReference type="SMR" id="C4YIU3"/>
    <dbReference type="PaxDb" id="5476-C4YIU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04372"/>
    <dbReference type="HOGENOM" id="CLU_698282_0_0_1"/>
    <dbReference type="OMA" id="VYKNYHY"/>
    <dbReference type="OrthoDB" id="312015at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021622">
        <property type="entry name" value="Afadin/alpha-actinin-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11559">
        <property type="entry name" value="ADIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="97"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ46028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="46076" checksum="074EBC442830C778" modified="2010-10-05" version="1">MPPQQLPPTDIQSIRNAAHALNSTLLSRTYIDENLQFNCINWKKLISDQLEVNPKLGELIITEKLYNNDKNTINLIHALVKIIDKQRSQQRVFNENILSKDNKIQTLEKQVQELSRKLHTLEKGNQNKVVKYNSLSKEINQLTKQNKIYSEDLQKVKNWTLDTKNKYKIEMKRKNLEIENLKNKLLEKTRNLPSNIEYGGNSDGLVIQNNAPIIENSTGLIINNPNLMIDMSSIITNEMEENSIQLVNIVESIAKENFKFTKFMSSIKEYFTKVNMSLSDFKYRDLETEKLPTPTDLIDLKEITADPETIKEYFTEIEPSEIIARTILNECYKLYHNIETLLNYISQNDPLDKDNESAIAKLQQDLEVMKSNWQDALKTSENWKKLAEQQQKHLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ46</accession>
    <name>C4YJ46_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CTP-dependent diacylglycerol kinase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ46"/>
    <dbReference type="PaxDb" id="5476-C4YJ46"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03858"/>
    <dbReference type="HOGENOM" id="CLU_031477_0_0_1"/>
    <dbReference type="OMA" id="TKHEVPR"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037997">
        <property type="entry name" value="Dgk1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303:SF1">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="38803" checksum="B25A9131B47C9CD7" modified="2009-07-28" version="1">MSSVPSSPIRNDSSFMVAEGQEARLRKEIKKTILDFDSNQSYIEEEDRTYIYNNSSILDDDDELEDAEAEDDEDSYELDDTEIEIEEDDSSIVLEKVANSTTDFSKDSNSSATEKPSLTFYQFLKKHEIPRKLFHSSIGVLTLWLYTIGVTVPQLFIPLGSVFTVLLVNDLVRLNNPVLNEKICSVMSFVIRDNEYNSYNGTLFYLMGVLIVLYAYPKDISVLSILLLSWADTAASTFGRAFGKYTPQIASGKSLAGCLASCVTGVLTAYLWYGYFIPQYNYWNQPGEIYWNASSNKLSLPIYSLLIGVITSISEVIDLAGIDDNFTIPVLSGTCIYWLVRLTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ94</accession>
    <name>C4YJ94_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Membrane protein PTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_03907</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LU7TM family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ94"/>
    <dbReference type="PaxDb" id="5476-C4YJ94"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03907"/>
    <dbReference type="HOGENOM" id="CLU_024065_1_0_1"/>
    <dbReference type="OMA" id="TWGFYDF"/>
    <dbReference type="OrthoDB" id="19932at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053938">
        <property type="entry name" value="PTM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21902">
        <property type="entry name" value="PTM1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944739" description="Membrane protein PTM1" evidence="9">
        <location>
            <begin position="18"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="PTM1-like N-terminal" evidence="11">
        <location>
            <begin position="28"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="10">
        <location>
            <begin position="189"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="487"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="501"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="563"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ45578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="577" mass="65570" checksum="8F077A6DBCC4E810" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJV4</accession>
    <name>C4YJV4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_04124</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AP-1-like"/>
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        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="109"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ45788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="176" mass="19600" checksum="11F4061712E1E2B1" modified="2009-07-28" version="1">MNVFTSWTKSNKAESVNSHETPQFASAVTQSNTTNSRPKGTESIGPGYGRVQDLSAHAIASQTQGSPSASSLEVKVDPELPKTHGHRIVSTTKRAEQNRNAQRAFRIRKANQFKELESKAKEVDQLKQKIESLEARNRSMANYICELQRQIIEFNSNKPPTKSDKNGRENNASTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK00</accession>
    <name>C4YK00_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_05792</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="EEQ47229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ergosterol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008204">
        <property type="term" value="P:ergosterol metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MBOAT_fam"/>
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        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
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        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF23">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="589"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ47229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="609" mass="71333" checksum="C7ACD6EEA94E5EB6" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK57</accession>
    <name>C4YK57_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonucleoside-diphosphate reductase small chain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_05853</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
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        <property type="protein sequence ID" value="EEQ47286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="PaxDb" id="5476-C4YK57"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05853"/>
    <dbReference type="HOGENOM" id="CLU_035339_2_1_1"/>
    <dbReference type="OMA" id="LEPMFLG"/>
    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ47286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="394" mass="45763" checksum="02D75F389A76967F" modified="2010-10-05" version="1">MSKNTDNNKPSPKKVTEKSTPIVTKPESDKTVEKASDDSEIDLPEVYKRHREFLAKHVVNRHKLKQEESNEPLLTPDKTRHTIYPIKYPELWQFYKKSLASFWTAEELDLSKDLDDWNNKMNENERFFISRVLAFFAASDGIVNENLVENFCAEVQIPEAKSVYKFQIMMENIHSETYSLLIETYFKDPEEADFLFNAIDNIPFIRKKADWAIRWIQSEDALYAERLVAFAAVEGIFFSGSFAAIFWLKKRGLMPGLTFSNELICRDEGIHTDYACLLFSYLKNKPSSEIIEKIITEAVDIEKEYFSDALPVSLLGMNCDLMCQYVEFVADRLLVAFGNKKYYNVTNPFDFMENISLAGKTNFFEKRVSDYQKAGVMEKVENKNEKTGLFDQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK68</accession>
    <name>C4YK68_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL5m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_05864</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK68"/>
    <dbReference type="PaxDb" id="5476-C4YK68"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05864"/>
    <dbReference type="HOGENOM" id="CLU_061015_1_1_1"/>
    <dbReference type="OMA" id="HITIHTT"/>
    <dbReference type="OrthoDB" id="539541at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="5">
        <location>
            <begin position="188"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ47297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="287" mass="32819" checksum="633CEE5A46B7BCDD" modified="2009-07-28" version="1">MNKHFIRSFSQSGVVLRPGYSTVNPVHHLVKVEKSKLRPGLKELLLPKDDIRSVKFKPTEISQDRVNEYYQNALQSDLLLHLYEHDAEPIIGNKKRSWGTDTPFKLYRPLRKPVGSTRPTKNIYPINNKNVPKLESIVVQSYNKNALELPWLNITTRLQLATITNVKPKILYGKSNILPWKVRVGRACGAKVELFDRDMSQFISTLTELVLPRIRAFKGIPRTSGDKNGNISMGLTPEDCQFFPELEHFQELFPNLNGLQITFKTTAQTDNHAKTLLSCYGFPFSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK89</accession>
    <name>C4YK89_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK89"/>
    <dbReference type="PaxDb" id="5476-C4YK89"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05886"/>
    <dbReference type="HOGENOM" id="CLU_049614_0_0_1"/>
    <dbReference type="OMA" id="NAFGHSQ"/>
    <dbReference type="OrthoDB" id="2430277at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00246">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="2">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ47319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="456" mass="46747" checksum="FFD96F3ADD793C76" modified="2009-07-28" version="1">MAAPPPPPPPPPPPPSGLGNLPPGPPPSMPPGRDALLGDIRKGARLKKATTVDKSKPMIDSKVSVSAAPPQASANSSGATNSLPSAPAVPQLGDIFAGGIPKLKHVDNRSGIVPSSAPKIPTLNTAQVPPRPTKTETSASVSTQEPSNLPPPVPPVAPPIPSQAPPPPTIQKRTPPKVPPTRPKKSSHIRNSSQNSNIAQEPSSKPPPLPSGPPPVPTSAPPLPNSIPPPPPLPAPPAPTVPEQSQKRNEGKVPTAPPLSSGGLPFLSEINAKRDDKNVISSAQSSNSAASPSVPGSLPPSIAKSSSSNASRIPNIPPAPPAPPAPPAPPIAPPLPAMGTSKEEKGTPKTNSSSIAPPAAGGSLPFLAQINAKRDDKFVVDGSNKSYTTRNEDTREPSSEISSKQTPDTKPVSLSNATSNTGKSSSAGKHHMSFNPFSQIKSRKIRHQSPHQFHKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKC7</accession>
    <name>C4YKC7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_05926</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkylbase DNA glycosidase AlkA family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKC7"/>
    <dbReference type="PaxDb" id="5476-C4YKC7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05926"/>
    <dbReference type="HOGENOM" id="CLU_000445_72_4_1"/>
    <dbReference type="OMA" id="FMFILWR"/>
    <dbReference type="OrthoDB" id="415889at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032131">
        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000045">
        <property type="entry name" value="DNA-3-methyladenine glycosylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000035">
        <property type="entry name" value="Alkylbase_DNA_glycsylse_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00516">
        <property type="entry name" value="ALKYLBASE_DNA_GLYCOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="5">
        <location>
            <begin position="150"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ47356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="354" mass="40635" checksum="639E49A451043ECD" modified="2009-07-28" version="1">MGAITRSKSITTKSVTSSTRKTTIVDSNSKLSQTSTENAKIIKKPKLSKPKPKLTKSTSDLEDLLTHITIPQDLSLPPKYIQDHTPEFIKGIQHILKIDPSLYPVIVHQNFKSFSSLIYTNVTMNENYNNSNDKENRIHTYWYSLIRSVIAQQVSGAAAKAIQTRFEGLFDGIPTPNKTLKFTPEELKSVGLSNMKVKYVQSISEAFNDPNNHLTRFEFYKQSKLDDILIELCKLKGIGIWSAKMFAMFTLEEMDVFAEDDLGIARGMARYLNKRPELLKQIKQECMNDEESQLLLKRKSKFANKTDSKRNWTPIHDAYVKYAAKRFSPYRSVFMMILWRLSSTNIDVLEKLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKD9</accession>
    <name>C4YKD9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mannan polymerase II complex ANP1 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_05941</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKD9"/>
    <dbReference type="PaxDb" id="5476-C4YKD9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05941"/>
    <dbReference type="HOGENOM" id="CLU_017872_0_0_1"/>
    <dbReference type="OMA" id="EHLPMFF"/>
    <dbReference type="OrthoDB" id="204164at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF2">
        <property type="entry name" value="MANNAN POLYMERASE II COMPLEX ANP1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="413"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ47368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="428" mass="49525" checksum="922ED3ACF6818CFF" modified="2009-07-28" version="1">MFYSLKTLIISIVIGIITLFTIYTQISNSKSGYAPNLSTFDTSQVQFYDLANYKGSANGWQYDERVLFCVPLRDAAPHLPMFFSHMKNLTYPHNLIDLAFLVSDSKDDTMGELKRHLSEIQKDPKLAFGEIEIFEKDFGQVIGQGFSDRHGFAAQGPRRKLMARARNWLWTVAVKPYHSFVYWRDADVETVPPTILEDLMHHDKDVIVPNVWRPLPDWLGNQQPYDLNSWQESEGGLQLADTLDEDACIVEGYVEYQTWRPHLAYLRDPYGDPEVEMDLDGIGGVSILTKANVFRQGSHFPAFSFEKHAETEAFGKLSKRMGFSVVGLPHYVIWHIYEPSSDDLKHMEWMASEEVRQQEEAKIKKVYDKVWNKAFEDVQNNWDKERSKFLKNTDMSNVRKIKVDWSGVDDFDIDKNSHDDKKLADFNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKJ1</accession>
    <name>C4YKJ1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exoribonuclease phosphorolytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_05995</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKJ1"/>
    <dbReference type="SMR" id="C4YKJ1"/>
    <dbReference type="PaxDb" id="5476-C4YKJ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05995"/>
    <dbReference type="HOGENOM" id="CLU_038194_0_0_1"/>
    <dbReference type="OMA" id="GPQFENG"/>
    <dbReference type="OrthoDB" id="10264038at2759"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11368">
        <property type="entry name" value="RNase_PH_RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000081">
        <property type="entry name" value="Exosome non-catalytic core subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033100">
        <property type="entry name" value="Rrp45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF14">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="6">
        <location>
            <begin position="37"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ47420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="337" mass="37793" checksum="1CDEC05630DB78F9" modified="2010-10-05" version="1">MSKELSLNQKNYLIQALKSNIRLSTSTNTGGSRKFNQFRPIDIKLSNTRYGSVELSLGKTKVMVNITSRITEPYQDRPFEGIMTINCEIPNHIKLQSNDTTNNNNDNEDEFINLINRALDRAIRRSNAVDLENLCIIAGEKVWELIIDLQVLNYDGNLIDSGCLAIITALLDFKKPDVTINNNNTSNSSSTSGGGGNIIVHDDEMKRPFIELSILHIPICLTFSLFNLGSKETNLKTNDIDQEIWLLDGDAMEESCRDGYLIMTMNQNHELIQLSKIGGGGNNGGVSIDGQQLINLCHESIDEINRLTNLVKSTVKNHQLNRYNNENYKLLESSADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKM2</accession>
    <name>C4YKM2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_06028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YKM2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06028"/>
    <dbReference type="HOGENOM" id="CLU_233699_0_0_1"/>
    <dbReference type="OMA" id="MQIKGQD"/>
    <dbReference type="OrthoDB" id="4026762at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10068">
        <property type="entry name" value="BONE MARROW PROTEOGLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10068:SF14">
        <property type="entry name" value="CELL WALL ADHESIN EAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1728"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1932"/>
            <end position="1955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1745"/>
            <end position="1757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1758"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1770"/>
            <end position="1898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1939"/>
            <end position="1950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="2013" mass="202161" checksum="D62C2AFE613FB355" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKM5</accession>
    <name>C4YKM5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_06031</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKM5"/>
    <dbReference type="PaxDb" id="5476-C4YKM5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06031"/>
    <dbReference type="HOGENOM" id="CLU_023062_3_3_1"/>
    <dbReference type="OMA" id="YEYKKWI"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08839">
        <property type="entry name" value="ArfGap_SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="8">
        <location>
            <begin position="15"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="7">
        <location>
            <begin position="24"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="142"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="281"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="323"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ47454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="42095" checksum="7D0A54696C41BC81" modified="2009-07-28" version="1">MALPSSKKTHSEQHKQILKQLLKEDANRTCADCKVSKNPRWASWNLGCFICIRCSGIHRSMGTHISKVKSVDLDAWTDDQIENMVKWGNANVNQYWEDKLPSGYIPDQSKIENFIRTKYDLRKWTMSKNLPDPLSLNKNKAATTATIQQPKHESKSHSNTTLSNDINLLDDNSGNKSNDEEFGSFTATRSPHKRSNKLALPPTKTVLPAAPTTSSSPQPQHQHQPLQSAQNTGGSVSSMGRPDLKKSILSLYASPSSSNSFIQQQQQQPLGMNSLSNSLSSLNIQGGNSTTNNNNVYRSSTTVNTQNNHTQHHPLVNSTPSLNNNQPKQNWNNEWTTDTFTSSPSIPSSSASSLAGTSNYKTTSSLNVNGLDDDLFKNVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKN2</accession>
    <name>C4YKN2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_06038</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKN2"/>
    <dbReference type="PaxDb" id="5476-C4YKN2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06038"/>
    <dbReference type="HOGENOM" id="CLU_012062_23_5_1"/>
    <dbReference type="OMA" id="EHASHAM"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001613">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF12">
        <property type="entry name" value="EUKARYOTIC INITIATION FACTOR 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="28"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="105"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ47461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="163" mass="18503" checksum="40697CD5DC031396" modified="2010-10-05" version="1">MSEEKVRVPETEEERQERLAKQEEIDGRSVYVGNVDYQSTPEQLEEFFHGVGVIERVTILFDRFSGLPKGYAYIEFEQTESVQKAIDELHGKEFRGRELRVTAKRTNLPGFRRGRGRGGFRARGRGRGGFRGRGRGRGGFNSRGTRNGDSEQADGDAENEETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKS6</accession>
    <name>C4YKS6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_06084</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKS6"/>
    <dbReference type="PaxDb" id="5476-C4YKS6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06084"/>
    <dbReference type="HOGENOM" id="CLU_291507_0_0_1"/>
    <dbReference type="OMA" id="LANNMFD"/>
    <dbReference type="OrthoDB" id="7451790at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="57"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ47505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1040" mass="117543" checksum="5F58AA8BF8FE9465" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKV6</accession>
    <name>C4YKV6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_06115</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKV6"/>
    <dbReference type="SMR" id="C4YKV6"/>
    <dbReference type="PaxDb" id="5476-C4YKV6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06115"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="OMA" id="LALHRCH"/>
    <dbReference type="OrthoDB" id="10250725at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08217">
        <property type="entry name" value="STKc_Nek2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000917">
        <property type="entry name" value="Serine/threonine-protein kinase KIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="7"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="375"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="282"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ47535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="428" mass="50721" checksum="086B941BB809859B" modified="2010-10-05" version="1">MSIIDEYESLEVIGKGSFGTVRRVRHKDGQILVRKEIEYTSMTSQERNHIISELRILRELDHPHIVKYYRHDHIPEKKMIHIYMEYCEGGDLAKVIKNFRASKSRIPEEFVWQVLVQVLLALYRCHYGVDAEKVNLFKTASEPKYANSIIHRDIKPDNIFVGSCIKLGDFGLAKMLSANDFAKTYVGTPYYMSPEVLLDDPYSPVCDIWSLGCVLYELCTLEPPFKAKSHLQLQAKIKRGVIEEVPDFYSSQLRTLIRSCITVDPEERPTCFDLIDSLAVRFLRKEMELKEMNENLEEYKKQLLKRSKELKETSKELDEYKQELVRKSEELSKREKYLDEEFELRKQAIELESKEIRMEYQREFNLVVEQEVKRRLEQRKPHGPRPLEDVSPRSPLKERNRPRVTDALERLHLEKRHTPEFEYISKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKZ5</accession>
    <name>C4YKZ5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dot6p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_01508</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YKZ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01508"/>
    <dbReference type="HOGENOM" id="CLU_536347_0_0_1"/>
    <dbReference type="OMA" id="DIPWTME"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="23"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="23"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ43276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="64895" checksum="BA1264B04D5024F2" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL80</accession>
    <name>C4YL80_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_01596</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL80"/>
    <dbReference type="PaxDb" id="5476-C4YL80"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01596"/>
    <dbReference type="HOGENOM" id="CLU_010084_1_0_1"/>
    <dbReference type="OMA" id="DQGFQYF"/>
    <dbReference type="OrthoDB" id="422427at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF1">
        <property type="entry name" value="ACTIVATOR OF STRESS GENES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="675"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="255"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="764"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="773"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ43361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="991" mass="111630" checksum="410ADC904C79E496" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL82</accession>
    <name>C4YL82_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_01599</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL82"/>
    <dbReference type="PaxDb" id="5476-C4YL82"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01599"/>
    <dbReference type="HOGENOM" id="CLU_001832_6_3_1"/>
    <dbReference type="OMA" id="CSLYDLW"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071826">
        <property type="term" value="P:protein-RNA complex organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022613">
        <property type="term" value="P:ribonucleoprotein complex biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001369">
        <property type="entry name" value="Putative pre-mRNA splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="368"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="561"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="110"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ43363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1070" mass="122003" checksum="5D233E971951DF96" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLL8</accession>
    <name>C4YLL8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="13">26S protease subunit RPT4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_01737</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLL8"/>
    <dbReference type="PaxDb" id="5476-C4YLL8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01737"/>
    <dbReference type="HOGENOM" id="CLU_000688_2_0_1"/>
    <dbReference type="OMA" id="DHEPCVI"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000008">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000034">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="205"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ43499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="428" mass="47819" checksum="2D5C9EF22DB79EE6" modified="2009-07-28" version="1">MSADENDPLLQALNADTNNNQDSNNANAGSTTTSAPAEPIDPERERALSKFKDKLLEHRKWDARLKDLRLSIRDLDKDYEKTENDIKALQSVGQIIGEVLKQLDDERYIVKASSGPRYIVGCRNTIKKENLKNGVRVSLDMTTLTIMRILPREVDPLVYNMTTFEPGEISFNGIGGLTEQIRELREVIELPLKNPELFTRVGIKPPKGVLLYGPPGTGKTLLAKAVAATIGANFIFSPASAIVDKYIGESARLIREMFAYAKEHEPCIIFMDEVDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDTLGQTKIIMATNRPDTLDPALLRAGRLDRKIEIGLPNEAGRLEIFKIHTSKVAKQGEFDFEAAVKMSDGFNGADIRNVVTEAGFFAIRDDRDYILQNDLMKAVRKVADVKKLEGKLDYEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLQ7</accession>
    <name>C4YLQ7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_01776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLQ7"/>
    <dbReference type="PaxDb" id="5476-C4YLQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01776"/>
    <dbReference type="HOGENOM" id="CLU_034106_0_0_1"/>
    <dbReference type="OMA" id="MNQEFEY"/>
    <dbReference type="OrthoDB" id="72772at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="104"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ43538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="441" mass="51644" checksum="DEE97722247BF7C7" modified="2009-07-28" version="1">MNPQFEINLPYVPPNIYKCVIKLWCQTNSDWKLLCLYKLNLRKMISVDNDLEILDLYKTNTLSLQLNDQWFTFQDMLNISIVDKNPNVLPQPIQSYTFDSIRCLNNLSNSLQELAISKHNLMQQIKLYIGNLQDYKNINNINVVLNKLQFQVHKLKHDVNKLTLQNEQLNNKIYNIKQKINDLHNIIESFNTNTKEIIENKLELYDTEIQNMQVLQLSLQQQLNKYLKTNMKSIEFVFPIDNIDSTKFSILGFQFPQDHQELLAICYYNKSSIELKNSYYQPEFDSETQWHNFKTQQINAALSIIVQLMVLIADITNTDYKYKMVLQGNQSYIVDEISKDYPITKKTLGNGNGTSSYRFPLYYDSTTNEKVIMSSGNQSMIMNQEFEYGLKLLNKNLVILIDKIQSLMIGDGSGNYDSHVPIECLDNILWNLKYLELFMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLR4</accession>
    <name>C4YLR4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cysteine proteinase 1, mitochondrial</fullName>
            <ecNumber evidence="8">3.4.22.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_01783</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.</text>
    </comment>
    <comment type="function">
        <text evidence="6">The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.</text>
            <dbReference type="EC" id="3.4.22.40"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer. Binds to nucleic acids. Binds single-stranded DNA and RNA with higher affinity than double-stranded DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.40" evidence="8"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLR4"/>
    <dbReference type="MEROPS" id="C01.085"/>
    <dbReference type="PaxDb" id="5476-C4YLR4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01783"/>
    <dbReference type="HOGENOM" id="CLU_038600_0_1_1"/>
    <dbReference type="OMA" id="QSYTFFW"/>
    <dbReference type="OrthoDB" id="2666448at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070005">
        <property type="term" value="F:cysteine-type aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043418">
        <property type="term" value="P:homocysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00585">
        <property type="entry name" value="Peptidase_C1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000021">
        <property type="entry name" value="Bleomycin hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004134">
        <property type="entry name" value="Peptidase_C1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363:SF2">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03051">
        <property type="entry name" value="Peptidase_C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005700">
        <property type="entry name" value="PepC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005700-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ43545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="500" mass="57368" checksum="871693EF412E56DB" modified="2009-07-28" version="1">MPASTKSPLPETEEEIFNEKSYSLTSTFDNFREQFEGLELENAENEINPISENILSKWEDDFKSQTKNLLAQNALAKNAIVDVIAKNSVGKQSLKDRYLFNITVDTIGSPAHLNNQKSSGRCWIFASSNVLRTHVIKNYNLKEDDFQLSQSYLYFYDKLEKANFFLENIEDTSSEDLDSRLISYLFSNPVNDGGQWDMIVNLVNKYGVVPNEVFPDNAQSTNSSKLNYVVTEKLREYGLKLRSLIAKDAPKNVISSFKASAIKSIYKTIALALGTPPKPTDEFLWEFIDKDGKYKSFKTNPLDFYKTYVRFDASEHFSLIHDPRNEYNKLYTVERLNNIFGGKPIEYINLEIDEIKQVAIKMLKDNEPVFFGSDVGKFSDSKSGILDTTAYDYSTAFDFSLDITKSQRLKVGSSQMTHAMVITGVHIDPQTNKPVRWKIENSWGEDSGQKGWFMMTDEWFDEYVFQIVTNKKYSGKKAYDIWKSKEFNTLPYYDPMGALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YME8</accession>
    <name>C4YME8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAWG_02028</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YME8"/>
    <dbReference type="PaxDb" id="5476-C4YME8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02028"/>
    <dbReference type="HOGENOM" id="CLU_010365_4_0_1"/>
    <dbReference type="OMA" id="HLARIMF"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000046">
        <property type="entry name" value="Probable ferric reductase transmembrane component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0410">Iron transport</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946760" description="FAD-binding FR-type domain-containing protein" evidence="17">
        <location>
            <begin position="23"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="410"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEQ43779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="730" mass="83569" checksum="EDB51795B4674C18" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMR1</accession>
    <name>C4YMR1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pex19p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMR1"/>
    <dbReference type="PaxDb" id="5476-C4YMR1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02145"/>
    <dbReference type="HOGENOM" id="CLU_043063_1_1_1"/>
    <dbReference type="OMA" id="YEPMKEM"/>
    <dbReference type="OrthoDB" id="21292at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033328">
        <property type="term" value="F:peroxisome membrane targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.900:FF:000007">
        <property type="entry name" value="PEX19 chaperone-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.900">
        <property type="entry name" value="Pex19, mPTS binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006708">
        <property type="entry name" value="Pex19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038322">
        <property type="entry name" value="Pex19_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774:SF2">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04614">
        <property type="entry name" value="Pex19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="37252" checksum="C1EA5AB05A6963C8" modified="2009-07-28" version="1">MSTNEVVDKSTLEQPKVNSETAKPVKEEKPAASAETKKSSNDDDLDDLDDLLDDFADDVLSKPPGASVSQRDDQSVKHESDKAKDPTDPLGNDFQKSINELISDLKIEDPDTQKQFEDLVKQFETNHRESVEAEEKKPANFEYVMKETMERLKKSGDDIDAKFKNDPLGSNPEDLLTQLLSGMGDAGDGDFDMSKLLVDMLEQLSSKEVLYEPIKDLNTKFPEYLQQNKDKLDEAKYKNYTQQYEITNDIVRIFESESYSEENKRQREQVNSLLESLQELGQPPSELVGETGDFLPGFGGGAGKGGDNPFGFDEKDLPPEFGKDLQEGCKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMT2</accession>
    <name>C4YMT2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_02169</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 19S cap proteasome complex which acts as a regulatory subunit of the 26S proteasome, involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively. Component of the lid subcomplex of the 19S RC.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMT2"/>
    <dbReference type="SMR" id="C4YMT2"/>
    <dbReference type="PaxDb" id="5476-C4YMT2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02169"/>
    <dbReference type="HOGENOM" id="CLU_031814_1_1_1"/>
    <dbReference type="OMA" id="RLHCKVD"/>
    <dbReference type="OrthoDB" id="1452at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000005">
        <property type="entry name" value="26S proteasome regulatory subunit N7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="193"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00093435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00093502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ43913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="400" mass="46250" checksum="9214E75E228B2564" modified="2010-10-05" version="1">MEIESDIPKIPDFQLSEKQFLLQHTDLEEKDRQHIIEEILQAIKKDHLAPYYHYLHTEISDFPYDESLYRELASENEKVIEELKSKIKEAEDEEDTELDVASTTTKLAEYYTKIIDRKNATETFKKVLELTPNTGSKIDHLLTLTRIDFFFNDLPSVQKHLEQIGQLSEKGGDWERRNRFKAYNGIYMLATRNFAEAAKLLIDSLATFTSTELCSYEAIAHCAIVAGVLSLERVDLKNKIIDSPEILSIASTTPNLEPLLNLTNSLYTCEYNCFFQYLLESYEKLLLPNKYLYKHANFFLREMRCKAYNQLLESYKSLSLKSMATNFNISEEFLDQDLCKFIPNKKLNCTIDKVNGIIETNRPDNKNNQYHALIKQGDNLLTKLQKYGAAVKLSGAERVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMV2</accession>
    <name>C4YMV2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="6">HMG-CoA synthase</shortName>
            <ecNumber evidence="6">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_02189</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="6"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMV2"/>
    <dbReference type="SMR" id="C4YMV2"/>
    <dbReference type="PaxDb" id="5476-C4YMV2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02189"/>
    <dbReference type="HOGENOM" id="CLU_008065_0_1_1"/>
    <dbReference type="OMA" id="DDAYNWI"/>
    <dbReference type="OrthoDB" id="1269963at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000008">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000590">
        <property type="entry name" value="HMG_CoA_synt_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01226">
        <property type="entry name" value="HMG_COA_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="7">
        <location>
            <begin position="7"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="8">
        <location>
            <begin position="178"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="4">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00073381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ43933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="451" mass="49767" checksum="586B89C3750709D3" modified="2009-07-28" version="1">MVMTNSPQNIGIKGIEVYIPGQAVNQSDLEKFDGIPQGKYTIGLGQTNMAFVNDREDIYSISLTVLSRLIKNYSIDTNKIGRLEVGTETLLDKSKSVKSVLMQLFPGNNDIEGIDTVNACYGGTSSVINAINWIESSSWDGRDAIVVAGDIAIYDKGAARPTGGVGAIALLIGPDAPIVFDSIRGSFMEHAYDFYKPDFTSEYPVVDGHFSLSCYVKAVDNCYKNYSKKITGDANKTVGVYDHFDFSAFHVPTCKLVTKSYARLLYNDYVSNPSKFADLIDETTRKHIDGLTYDESLTDKILEKTFVGLAKDETKKRVQPALQVPTNTGNMYTASAWVSLASLLYYVGSDNLKNKRISIFSYGSGLASTLLSVTVKGDVSAITKVLDFDYKLGDGRKIQSPEDYLAAIELREKAHLQKSFKPQGSIDNLSQGTYYLTEIDDKFRRAYAIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMY0</accession>
    <name>C4YMY0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_02217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMY0"/>
    <dbReference type="PaxDb" id="5476-C4YMY0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02217"/>
    <dbReference type="HOGENOM" id="CLU_056986_1_0_1"/>
    <dbReference type="OMA" id="FAGPQHF"/>
    <dbReference type="OrthoDB" id="347435at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="39281" checksum="56C2343F749C244F" modified="2009-07-28" version="1">MDDTLTISIDFIDDQIQQYDFNEPLIIGISGPQGSGKSYLTNQLYNYLQTKYHPNLKTIQFSMDDFYLCKSDQDKLNDSTENPLLKGRGLPGTHELSLLVDTFNKLINNYKQFKKSHLESESESESDWEVIKIPSYDKGAFNGIGDRSNDKYYTLIESPIDIIIFEGWFNGFYSLDPTILQLKYLTSSPSPTPENNNNNNNNNNHISLQSFKLYDLQEINKNLQNYESSIWSFFKISIIFQTDQINNVYPWRLQQEHELIAKQQQQQQQQKSVEGTCDQIGMKNDDEIIKFIDRYMPIYLLYYENLCDYGIKHCKNLIISIDSNRRVIKNRVLNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN51</accession>
    <name>C4YN51_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN51"/>
    <dbReference type="PaxDb" id="5476-C4YN51"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02291"/>
    <dbReference type="HOGENOM" id="CLU_1927290_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944337" description="Secreted protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="13195" checksum="9E83EB82670EF8DC" modified="2010-10-05" version="1">MKTSVVLAAALTAMNTANAAVIPFFDGELSINYDAHSGWSFGFDKQPAQSGSPPATTTPGSGSGSTTTPATTADDGDDDEGSCDDSGSAPPANNGGSNGSSSGSGDYFSQWKQGLDNLIQKGKTWFSGLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN93</accession>
    <name>C4YN93_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase assembly protein COX16, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cytochrome c oxidase assembly protein cox16, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_02333</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COX16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN93"/>
    <dbReference type="SMR" id="C4YN93"/>
    <dbReference type="PaxDb" id="5476-C4YN93"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02333"/>
    <dbReference type="HOGENOM" id="CLU_131611_1_0_1"/>
    <dbReference type="OMA" id="VNMKDEY"/>
    <dbReference type="OrthoDB" id="5516033at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020164">
        <property type="entry name" value="Cyt_c_Oxase_assmbl_COX16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130:SF14">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX16 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14138">
        <property type="entry name" value="COX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ44074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="128" mass="15377" checksum="C684D71787F45775" modified="2009-07-28" version="1">MSYSGNRVFRGKKEQEAYDKTLAGRYVKLVKKNHFLFFGLPFLVSIVAGSIYLQKFTSVKWEKYDEKYQQLGEEEMLNLIENKRTVDKKNDYYRLQGLLNDHTNQVADDYEIVRVQRRKEDEPVWDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNA3</accession>
    <name>C4YNA3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_02343</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNA3"/>
    <dbReference type="SMR" id="C4YNA3"/>
    <dbReference type="PaxDb" id="5476-C4YNA3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02343"/>
    <dbReference type="HOGENOM" id="CLU_084338_0_0_1"/>
    <dbReference type="OMA" id="HQTLYSE"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048938">
        <property type="entry name" value="ATPD_C_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21334">
        <property type="entry name" value="ATPD_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="14">
        <location>
            <begin position="32"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="F1F0-ATP synthase subunit delta C-terminal" evidence="15">
        <location>
            <begin position="123"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEQ44084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="161" mass="17582" checksum="1E86DAF57EDC7292" modified="2010-10-05" version="1">MFRQVFRQVTKQSFTGVKRTYATEAAVSTDALKLSLALPHQTLYNDSEVQQVNLPSVNGDLGILANHIPIVEQLRPGLLEIISKNGDSDQYFVSGGIAMVQPGNKLTISAIEAFKTDQIDLSAVKNLIADAQKRAESSDEKVAAEANIELEVLDALQHFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNF5</accession>
    <name>C4YNF5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trehalase</fullName>
            <ecNumber evidence="5">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_01415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="5"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNF5"/>
    <dbReference type="PaxDb" id="5476-C4YNF5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01415"/>
    <dbReference type="HOGENOM" id="CLU_006451_1_1_1"/>
    <dbReference type="OMA" id="WLFMMTK"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000026">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011120">
        <property type="entry name" value="Trehalase_Ca-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF6">
        <property type="entry name" value="CYTOSOLIC NEUTRAL TREHALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07492">
        <property type="entry name" value="Trehalase_Ca-bi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neutral trehalase Ca2+ binding" evidence="7">
        <location>
            <begin position="234"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="907" mass="103955" checksum="A435B0A05EF73D8A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNL2</accession>
    <name>C4YNL2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_01474</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNL2"/>
    <dbReference type="PaxDb" id="5476-C4YNL2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01474"/>
    <dbReference type="HOGENOM" id="CLU_010104_2_0_1"/>
    <dbReference type="OMA" id="CNTSEDW"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21386">
        <property type="entry name" value="GAT_Hse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16978">
        <property type="entry name" value="VHS_HSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="14">
        <location>
            <begin position="11"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="212"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="136"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="374"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="392"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ43245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="498" mass="56547" checksum="E2CE660F7BB20F49" modified="2009-07-28" version="1">MTSLDVLINKATDPTLTSDNWQYILDVCDRISADPETETKRTITILKTKLTSKDANVVLRSLSLLISIAENCGSRVKQEIATKSFLQDALVKRLSDKKLHATVKYKICEVLTQLYNAFKGDPSLKPMTDAYNKARSEHPRYFSKQTQGPSKPAKKERTQQDKDREEDELQRALKLSLQEFEQQKTGKKEPDVNKPLPEIQPEPESPPVETVATVSKVRALYDLVSYEPDELSFRKGDVITVIESVYRDWWRGSLPSGKIGIFPLNYVTPIVNKSPQDIAKEIEIENKLITEEQRKIERLLAILSSQQIETINEDEVTHLYNEIIPLRIQLGNSIDKYGARQEELKVLNQSLNSEIKLYNELLDKSISSRAKHNTGGAMYQMSPYPTEQFPGQSQPQLSQQHHQPYAQPQQTSNYAQQSQTVPPQFTQSQQTQPQYHQSHTRTGSHQEVPQYSGYNSNNIPPPPATTFNQYPPSQLQQQDTSAGFGNDVYNKAAPGQPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNN6</accession>
    <name>C4YNN6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 20">Autophagy-related protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CAWG_02816</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(out)</text>
            <dbReference type="Rhea" id="RHEA:67920"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 20">Preautophagosomal structure membrane</location>
            <topology evidence="3 20">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 20">Belongs to the ATG9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNN6"/>
    <dbReference type="PaxDb" id="5476-C4YNN6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02816"/>
    <dbReference type="HOGENOM" id="CLU_006200_1_0_1"/>
    <dbReference type="OMA" id="ELMTISW"/>
    <dbReference type="OrthoDB" id="2020634at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007241">
        <property type="entry name" value="Autophagy-rel_prot_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038">
        <property type="entry name" value="APG9 AUTOPHAGY 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038:SF10">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04109">
        <property type="entry name" value="ATG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 20" id="KW-0072">Autophagy</keyword>
    <keyword evidence="15" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13 20" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 20" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="570"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="620"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="583"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="624"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU364027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EEQ44545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="716" mass="83641" checksum="52929AF3940F34DA" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNY9</accession>
    <name>C4YNY9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNY9"/>
    <dbReference type="PaxDb" id="5476-C4YNY9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02922"/>
    <dbReference type="HOGENOM" id="CLU_2277074_0_0_1"/>
    <dbReference type="OMA" id="MIFNIAV"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944360" evidence="2">
        <location>
            <begin position="18"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="105" mass="12616" checksum="AE10C7E20478C111" modified="2010-10-05" version="1">MLYFFFLFGSSIFPVESNNRIYKFVCYKSIFICVFAIVTVNVVIMIFNIAVLKKKKRNLYVYFFFFFFISFHLFLAILLCVCVCQSQNFSIFFTCIKKRHANKWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP36</accession>
    <name>C4YP36_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_02972</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YP36"/>
    <dbReference type="PaxDb" id="5476-C4YP36"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02972"/>
    <dbReference type="HOGENOM" id="CLU_004134_1_0_1"/>
    <dbReference type="OMA" id="MDESECR"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000314">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF51">
        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1064"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="873"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="873"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="893"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="915"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="928"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="981"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="993"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ44695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1200" mass="135364" checksum="0B18105D844520E0" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPD7</accession>
    <name>C4YPD7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_03090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPD7"/>
    <dbReference type="PaxDb" id="5476-C4YPD7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03090"/>
    <dbReference type="HOGENOM" id="CLU_1204629_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ44796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="230" mass="26094" checksum="96AEFF8234F38B5E" modified="2009-07-28" version="1">MDISNHQPNVSQTVPFLFNVLQVILNVFWEFVRVPFIQRVDVLGVWQLQVWMGQDKFTQSSIQSEKIDTVTCSQCQMGRCTVHGVPRSDHLLTRTQDIADATSRPLLQLVHTKNRTNRNTSIDIGRPINWISTNSICATTWEHNKVFLLFRNQNLDVVGRSHGIDKDLITNHIQFLSNITGRVGRARNTNKVDQLSSSDIVGNKLECKLKRIQQQRQLTGGGGSNSLSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPM6</accession>
    <name>C4YPM6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADPH-dependent 1-acyldihydroxyacetone phosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_02427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPM6"/>
    <dbReference type="PaxDb" id="5476-C4YPM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02427"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="OMA" id="GGTPDWF"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000261">
        <property type="entry name" value="NADPH-dependent 1-acyldihydroxyacetone phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ44165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="293" mass="32417" checksum="AEAB49A13E85C1DD" modified="2010-10-05" version="1">MSERQKVALVTGASSGIGYATAIEFAKRGYKVFAGARRLEPMQKLKDDYGVIIFKLDVSDLESVKNAKKFIESETGADYLDFLYNNAGQSCTFPATDVTDAQMKQCFEVNVFGAIRTVRELVPLIINAQGVIGFTGSVSGIIPFPFSCIYSASKAAIHQYAATLRLEMKPFGVKVINIVTGGVKTDIEDKRDLPESSIYNVPGIKEAFNERRQMAARNKPMPAEVYAKKVVTDFESANLGGALNIYRGTMSTFLSFVLTFVPRFIVEAALVSKFKLNSVFQYLHEKYSKEKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPW6</accession>
    <name>C4YPW6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Plasma membrane proteolipid 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_02520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPW6"/>
    <dbReference type="PaxDb" id="5476-C4YPW6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02520"/>
    <dbReference type="HOGENOM" id="CLU_107649_7_2_1"/>
    <dbReference type="OMA" id="ACFIICW"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF42">
        <property type="entry name" value="UPF0057 MEMBRANE PROTEIN ZK632.10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ44255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="55" mass="6230" checksum="7CB293C565735BAA" modified="2009-07-28" version="1">MNSEKIIEVIIAIFLPPVAVFMKCGATTPLWINLVLCIFIWFPAILHALYVVLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ17</accession>
    <name>C4YQ17_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L9-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_02571</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ17"/>
    <dbReference type="SMR" id="C4YQ17"/>
    <dbReference type="PaxDb" id="5476-C4YQ17"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02571"/>
    <dbReference type="HOGENOM" id="CLU_065464_0_0_1"/>
    <dbReference type="OMA" id="YAHFPMK"/>
    <dbReference type="OrthoDB" id="10252633at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000003">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000004">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002359">
        <property type="entry name" value="Ribosomal_uL6_CS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00700">
        <property type="entry name" value="RIBOSOMAL_L6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="97"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ44306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="191" mass="21718" checksum="24E0D51025DC32B8" modified="2010-10-05" version="1">MKYIQTDQILDIPEGVTVDIKARVVKVTGPRGELTKDLKHIDVTFNKINNRAIKITVHNGDRKHVAALRTVKSLIANLITGVTKGYKYKMRFVYAHFPINVNIIKKDGQDYVEIRNFLGEKRVREVKIHEGVTMEISSTQKDELIVSGNSLEAVSQNAADIQQICRVRNKDIRKFLDGIYVSERGTIVEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ29</accession>
    <name>C4YQ29_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_02583</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">WO-1</strain>
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            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
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            <dbReference type="ChEBI" id="CHEBI:58608"/>
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        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
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        <location>
            <begin position="20"/>
            <end position="38"/>
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        <location>
            <begin position="113"/>
            <end position="129"/>
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            <begin position="80"/>
            <end position="197"/>
        </location>
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            <end position="279"/>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="293" mass="32262" checksum="BD4A85C43B17CA75" modified="2009-07-28" version="1">MSAVSSFFTKLKFYLKSGLYGTLVAGCAIYGVLASIILRIVNKAEYAQYAVAKACYYVVSLFLGLKINIKNEKYLQNLPAIVVANHQSALDIYVLGKIFQPGYTVTSKKSLKYVPFLGWFMVLSGTFFLDRSKSASAKKVLDGALTGLKNQGKALFIFPEGTRSATEDLTMLPFKKGAFHLARQAGIPIIPVVVSNTSTIFNSKRKIFNTGEINIEVLPPVSTSDWETHEDVTNACNNIRDDMIKTLKKLGNSKIPGSKPREDFYPSESEDTSETDVEIINEQTPLKATAVSD</sequence>
</entry>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Grabherr M."/>
                <person name="Forche A."/>
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                <person name="Logue M.E."/>
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                <person name="Nikolaou E."/>
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                <person name="Silverstein K.A."/>
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                <person name="Staggs R."/>
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                <person name="Lorenz M.C."/>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">WO-1</strain>
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    </reference>
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            <end position="23"/>
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    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ44392.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
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                <person name="Forche A."/>
                <person name="Reedy J.L."/>
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                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ44444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="49" mass="6246" checksum="F42F1BE0A840D650" modified="2009-07-28" version="1">MKESFMYKSVDARECRFSIWYCCVNDMVFWLLRYCNYVCDIIDCFWRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQH0</accession>
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            <fullName evidence="1">Endoplasmic reticulum junction formation protein lunapark</fullName>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
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                <person name="Santos M.A."/>
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                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lunapark family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQH0"/>
    <dbReference type="SMR" id="C4YQH0"/>
    <dbReference type="PaxDb" id="5476-C4YQH0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02728"/>
    <dbReference type="HOGENOM" id="CLU_043850_2_0_1"/>
    <dbReference type="OMA" id="CGYFNPS"/>
    <dbReference type="OrthoDB" id="1725934at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="4">
        <location>
            <begin position="235"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="301"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ44459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="344" mass="39743" checksum="4F7FE6DA8183DF51" modified="2010-10-05" version="1">MGVFSIFGSKESFDPNVFEKELTSITEKINTNKQQISKLQQRQKYVRRSLSRYFIIIYLCIFGYCYATIPSSTIGKNRVQWFIRGQTRQHLLVLIGYPLFSVLTLRAVSYIFQFFINNKQSYLKSLQNKHKEKIEELKKITNFNKTNELINKYGNEKQPQVSLQKQEPQPISNQKQQDHLRNRHNKSGNLRDQAMKELNLPEDKQLSSQQKGQLPNTKQAPIPAIPQQPAQRTIQDRLLDILIGSDNSESVENRYALICFHCFAHNGLAPPHTEDPADVKFQCWKCGAMNGKGMLFEQPDMKFDSSKNSSSELINLEVKEKESGNLDHPGTENEEKEESTKKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQJ0</accession>
    <name>C4YQJ0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_02748</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQJ0"/>
    <dbReference type="SMR" id="C4YQJ0"/>
    <dbReference type="PaxDb" id="5476-C4YQJ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02748"/>
    <dbReference type="HOGENOM" id="CLU_003181_2_2_1"/>
    <dbReference type="OMA" id="MFLKINM"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000011">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF9">
        <property type="entry name" value="ANION_PROTON EXCHANGE TRANSPORTER GEF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="449"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="496"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="527"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="582"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="669"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ44479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="768" mass="85601" checksum="5926A93DF8E8B832" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQK8</accession>
    <name>C4YQK8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NuA3 HAT complex component NTO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_02767</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQK8"/>
    <dbReference type="PaxDb" id="5476-C4YQK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02767"/>
    <dbReference type="HOGENOM" id="CLU_002663_1_1_1"/>
    <dbReference type="OMA" id="CMINKNR"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15492">
        <property type="entry name" value="PHD_BRPF_JADE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000007">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="223"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="277"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ44497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="759" mass="86940" checksum="C72F49E451197E79" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQM7</accession>
    <name>C4YQM7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQM7"/>
    <dbReference type="PaxDb" id="5476-C4YQM7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02786"/>
    <dbReference type="HOGENOM" id="CLU_044221_0_0_1"/>
    <dbReference type="OMA" id="TINHRFQ"/>
    <dbReference type="OrthoDB" id="4012911at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="54249" checksum="4BCB973C38C6FE83" modified="2009-07-28" version="1">MHEEIDHTLTSSSTTGSASFNKRSNFQFTYDSETHLLLLIHKYKEDIFTRGNIIKTWEKVLQEFNERCHSNIVQSRTINHRFQMLKKNLENRLKHDNQLLDQVVLNENEKLLVDILEYMYKNSHTEVSPYSLGGSSNNSNIAANTQIDSLYAQQNPTAPIDNPLAIADMSQISPNTYEHKLNRDRAQYLMSQGFDHSIHHQFQNSMDFSNTIRQHQLAPSSGNSSLGANKNIVSGYVPSLEQPELINTSNQIGHPEETMLQPHPNNQASSHIIYKQPEINMSTSESPNLQHNSQHQPRHSNSSTPMGSSASTSHHQQQQQSSHDTKQNFGNNISPSIQYNNNTNTRTIDFAYRQDQNQDQNQNPQQHQYQTQPQQDNTTVSLLKQLIVSQTQVTHSINALREDLSDFKRETNQRIDRLTSDYSLQQNNSMNQKLDSLIRMLRSQNLKSVHSSPTDEDMTNENDSSYGADQGTSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQR0</accession>
    <name>C4YQR0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Threonine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_04407</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQR0"/>
    <dbReference type="PaxDb" id="5476-C4YQR0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04407"/>
    <dbReference type="HOGENOM" id="CLU_008554_0_2_1"/>
    <dbReference type="OMA" id="WYADGMY"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000009">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="15">
        <location>
            <begin position="55"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="289"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEQ46063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="706" mass="81757" checksum="12B587863EB6A969" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR62</accession>
    <name>C4YR62_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="4">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_04561</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol 1,4,5,-trisphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="4"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR62"/>
    <dbReference type="PaxDb" id="5476-C4YR62"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04561"/>
    <dbReference type="HOGENOM" id="CLU_002446_2_0_1"/>
    <dbReference type="OMA" id="ANYFRCE"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05168">
        <property type="entry name" value="PI4Kc_III_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000021">
        <property type="entry name" value="Phosphatidylinositol 4-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000016">
        <property type="entry name" value="PIK1p Phosphatidylinositol 4-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021601">
        <property type="entry name" value="Phosphatidylino_kinase_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057754">
        <property type="entry name" value="PI4-kinase_beta/PIK1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049160">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21245">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11522">
        <property type="entry name" value="Pik1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="13">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="12">
        <location>
            <begin position="679"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="205"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ46215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="977" mass="110683" checksum="51FD3DCFD1719141" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR77</accession>
    <name>C4YR77_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc-finger protein GIS2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR77"/>
    <dbReference type="PaxDb" id="5476-C4YR77"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04576"/>
    <dbReference type="HOGENOM" id="CLU_058879_2_0_1"/>
    <dbReference type="OMA" id="EHKQCYN"/>
    <dbReference type="OrthoDB" id="3863715at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000085">
        <property type="entry name" value="Zinc knuckle nucleic acid binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="175" mass="18668" checksum="9BD61CA4EA6C4B63" modified="2010-10-05" version="1">MAAVYPRTCYKCGEVGHVADDCQQEERLCYNCHKPGHESNDCPDPKQNTAKQCYSCGDVGHIQTECPNQAQGAKCYNCGQFGHISKNCDSAPSSTNNAPSFKRPSGRASGTTCYKCGGPNHFARDCQANTVKCYACGKVGHISKDCHSSAGGSNFSAKTCYNCGKSGHISKECTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRC9</accession>
    <name>C4YRC9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ecm33p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_04628</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRC9"/>
    <dbReference type="PaxDb" id="5476-C4YRC9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04628"/>
    <dbReference type="HOGENOM" id="CLU_035846_0_0_1"/>
    <dbReference type="OMA" id="GHNYECT"/>
    <dbReference type="OrthoDB" id="536881at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.20.20:FF:000040">
        <property type="entry name" value="Cell surface GPI-anchored protein ECM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.20.20:FF:000064">
        <property type="entry name" value="Cell surface GPI-anchored protein ECM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051648">
        <property type="entry name" value="CWI-Assembly_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018:SF3">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946958" description="Ecm33p" evidence="10">
        <location>
            <begin position="21"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="347"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="356"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ46282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="43598" checksum="3655D9E8D629BD5C" modified="2009-07-28" version="1">MQIKSFLLPIVAALLTSVSAADSSNKCSFSKTSITEATGISQLNACSTLDGEITVSGSGIGSIDLSSVKVLKAKLSILNSPSIVSLNFNQLQNITGALVINNATQLNSIDLTQLTNVETLQLVSLPSFAILNLNQGVQKAGTIVLSDTALTNLNGLASFNTIDSININNNKNISKIEFSDLQTVTDSLILSFNNDDAEVKLDSLKWAGNLTIQDVSSIQASNLTSVNGSLLISYNTFDELEFPNLKSVGNSMQIFAHDELTKISFPKLSELDGELEMFNNTQLEEIDFGNLTTIKGAVTISGPFDNLTMENLKLVSGDFQVNSTSDKFDCSAFDKLHEKGKIEGHNYVCTHPANPSSSSKSGSSTQTGKSDSKSSDGSSSSNSSSSSKKGAGNVLVVPGMVLTTALGVLLALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRF1</accession>
    <name>C4YRF1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_04650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRF1"/>
    <dbReference type="PaxDb" id="5476-C4YRF1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04650"/>
    <dbReference type="HOGENOM" id="CLU_039185_1_0_1"/>
    <dbReference type="OMA" id="LFFRYWY"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="65"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ46304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="522" mass="59670" checksum="EAFAD361681A50CA" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRV0</accession>
    <name>C4YRV0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRV0"/>
    <dbReference type="ESTHER" id="canal-q5akr2">
        <property type="family name" value="FSH1"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YRV0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04807"/>
    <dbReference type="HOGENOM" id="CLU_051938_2_2_1"/>
    <dbReference type="OMA" id="EEPRGWW"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000780">
        <property type="entry name" value="Putative serine hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="283" mass="31708" checksum="2AC51DB77830071C" modified="2010-10-05" version="1">MPPKKNVTYKGKILFLHGYTQSASLFYAKTSALRKKLIKLGYRCVYLNGPYVLTPADLPTTDSLSKFGSATTDTDDVTYRAWWVKKDKTNDAINLDESIATIKNYIQKGEIIADNDLKVEEETEEEKKLPIVGILGFSQGAAFGGVVAHKFHELFETDPLKFVVLYSGFKLDTSKKAGNDKYDEYYPQTEEEVKSGGFKYLHVLGELDTVVAEDRGYSLYEHTKSSSDILKHPGGHFVPNSKMYVDNVANWIEAHQNGSQSKSEAPEDDIDSLLDMMDNFGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRW7</accession>
    <name>C4YRW7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRW7"/>
    <dbReference type="PaxDb" id="5476-C4YRW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04824"/>
    <dbReference type="HOGENOM" id="CLU_065213_0_0_1"/>
    <dbReference type="OMA" id="LMEMLFY"/>
    <dbReference type="OrthoDB" id="124397at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001874">
        <property type="entry name" value="Uncharacterized protein yjr088c homologue, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="302" mass="35532" checksum="E8367B2F4C727142" modified="2009-07-28" version="1">MSSDPVLVKKKLLQIASTGKYATFTPEQLHAHYEELQDFLILNQDSLLDSIELFNLYELQFYLSILTLHDIEAKNVLDKICDQFDFKDSNKNKGRSQRIKILQSVYAESKGEIETASKLLSEDPDELRLSRRLTTLSRHDKNPTKYINNLIYYLNLQPSDLIAWAELSEQYQKLGNYDKSIYCLKEVVLQNPLAYPIFYKIGLLYYYLFLQNEGNLKTDKKDKLFELMKILINSRDNYLYSLEINDKYEKNWVGLKTIVSLSFNDKLKKISESSKEIKDYLNYNEKLKPIIDRKLKELNISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS48</accession>
    <name>C4YS48_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AP-1 complex subunit mu-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_04906</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS48"/>
    <dbReference type="SMR" id="C4YS48"/>
    <dbReference type="PaxDb" id="5476-C4YS48"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04906"/>
    <dbReference type="HOGENOM" id="CLU_026996_0_0_1"/>
    <dbReference type="OMA" id="KPLIWCD"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09250">
        <property type="entry name" value="AP-1_Mu1_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000006">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="8">
        <location>
            <begin position="174"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ46551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="438" mass="50205" checksum="4AC69F6C68477046" modified="2010-10-05" version="1">MASQIHFLDIKGKPLLSRDYKGDISSTTIEKFPLLLLELENTVDDGEYKPFINHEGINYIFINHNNLYICALTRKNENIMTIIIFLSKLVEVMTQYFKSLEEESIKDNFVIIYELLDEMMDFGVPQTTDTKILKEYITQDYYSLIKSTPTHLVAPPNALTNSVSWRKEGIFYKKNEAFLDVIESINMLITANGQVLNSEILGEIKIKSHLSGMPDLRLGLNDKGIFTGNNDATTDSGKNIEMEDIKFHQCVRLSKFENEKLITFIPPDGEFTLMSYRLSSSQFLMKPLILVNCKTKVHKHSRIEIVCTVKAQIKKKSTANNVEVVIPIPEDADTPKFSPEYGSVKWIPEKSCLIWKLKTFPGGKQFSMRAELGLPAVTDPESIMSKKPIKVNFSIPYFTTSGIQVRYLRINEPKLQYQSYPWVRYITQSGDDYIVRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSI2</accession>
    <name>C4YSI2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSI2"/>
    <dbReference type="PaxDb" id="5476-C4YSI2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05048"/>
    <dbReference type="HOGENOM" id="CLU_077445_0_0_1"/>
    <dbReference type="OMA" id="QIFNHSE"/>
    <dbReference type="OrthoDB" id="4026228at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="317"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="361" mass="41732" checksum="754615FB712CE1E8" modified="2009-07-28" version="1">MNIEAEDDDDLLNELDHELKNTQTSKVSFKKKSFNKPQKIQRNKLSFNIDDEEEDEEKEGHDGDKNNINGLKPVPSKGASLLRFNPRTKFTKEKSSETKQPVKKPINLSRYQIDTKTTTTTDNADQEIIPFELDEEDPENNPVITNIDDLNDEDNEEFAKLKSKLIATTTTSQIFNHSEVLTSANKDTPKRYVPIETNRVPESSKLSIRQYTKALVNEYKDDKNYDDGTERQNQEDQDLLLHDINDGDIELNDEDMGILNIGKRANFDDNKFNFEIHSDDDDEKEESDDRLHSENESNDNGNIDFRIPTVEEQIMRINGLIKQLEVTKSEKQKLVQNLKIERDELTETKSELLEKLNNLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSX5</accession>
    <name>C4YSX5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Maintenance of telomere capping protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSX5"/>
    <dbReference type="PaxDb" id="5476-C4YSX5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05670"/>
    <dbReference type="HOGENOM" id="CLU_042692_0_0_1"/>
    <dbReference type="OMA" id="RIHLVHD"/>
    <dbReference type="OrthoDB" id="5594977at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018814">
        <property type="entry name" value="DUF5427"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10310">
        <property type="entry name" value="DUF5427"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="41079" checksum="885F57D31DB25177" modified="2009-07-28" version="1">MTKPTKDNNDDVLDFINSLPDSKPGTPKPSKTSGSNTGGGNDSTENKEDLLDFLDELEQHEKTKKTKKPSKLAPKTASKPTSSDADDEPTTGTTTDKSDTTNEDIEPQQPQEKVNEESDNQDIPNPISSITSWWNSEGSNKVNSLWGKITDNAEKLSEQTYQLANDATNQLNTRARNLDTDQITGQLNNLFHNVSNTLKQGLIEEADEILNVSIINEINYDAINVNNLVLDNFLKVVNQVEGRIHVRLNEFNQGQEEQIKKNQEDQVEHHQEQSNIVITCNANQDEENKLVYFEITLKDITNGITITNKSQSLPLQWWKWIQGEKLEFDESIDPKEWVKTWVKNGLDLSVGISVQQYIINRMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT50</accession>
    <name>C4YT50_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Exportin-T</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Exportin(tRNA)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA exportin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_05749</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <text evidence="9">Shuttles between the nucleus and the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT50"/>
    <dbReference type="SMR" id="C4YT50"/>
    <dbReference type="PaxDb" id="5476-C4YT50"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05749"/>
    <dbReference type="HOGENOM" id="CLU_004414_0_1_1"/>
    <dbReference type="OMA" id="HEMFLFG"/>
    <dbReference type="OrthoDB" id="26399at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001358">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045546">
        <property type="entry name" value="Exportin-T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040017">
        <property type="entry name" value="XPOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952:SF11">
        <property type="entry name" value="EXPORTIN-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952">
        <property type="entry name" value="EXPORTIN-T/LOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19282">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <keyword evidence="6 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="10">
        <location>
            <begin position="100"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-T C-terminal" evidence="11">
        <location>
            <begin position="334"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ47186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1025" mass="118464" checksum="18A3A33C1F40B5D5" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTB3</accession>
    <name>C4YTB3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_05399</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0357 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTB3"/>
    <dbReference type="SMR" id="C4YTB3"/>
    <dbReference type="PaxDb" id="5476-C4YTB3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05399"/>
    <dbReference type="HOGENOM" id="CLU_128832_0_0_1"/>
    <dbReference type="OMA" id="NIRDGDS"/>
    <dbReference type="OrthoDB" id="447314at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018559">
        <property type="entry name" value="DUF2015"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023:SF1">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09435">
        <property type="entry name" value="DUF2015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ46854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="153" mass="17637" checksum="B2240B143B83855D" modified="2010-10-05" version="1">MDNLQQQEQNTIAYSYFVDESGKSRVKSQHVLLVIIILVCLLVFHFRHKIIELHDRYRTRSRIDSGYYSNLQSFEDDVASGLSSSNFDLESNNIATNDNRAGLSESAKLQIKKIMEEKGVSFDDARLEYTRNELSKNNIDENGVPRDPKLVMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTF2</accession>
    <name>C4YTF2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTF2"/>
    <dbReference type="PaxDb" id="5476-C4YTF2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05442"/>
    <dbReference type="HOGENOM" id="CLU_340646_0_0_1"/>
    <dbReference type="OMA" id="FGFINWN"/>
    <dbReference type="OrthoDB" id="5596576at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1004" mass="114378" checksum="BD044126CBA73BEF" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-07-27" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTG0</accession>
    <name>KEX1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>Pheromone-processing carboxypeptidase KEX1</fullName>
            <ecNumber>3.4.16.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Carboxypeptidase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">KEX1</name>
        <name type="ORF">CAWG_05452</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Preferential release of a C-terminal arginine or lysine residue.</text>
            <dbReference type="EC" id="3.4.16.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.6"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTG0"/>
    <dbReference type="SMR" id="C4YTG0"/>
    <dbReference type="ESTHER" id="canal-q5afp8">
        <property type="family name" value="Carboxypeptidase_S10"/>
    </dbReference>
    <dbReference type="MEROPS" id="S10.007"/>
    <dbReference type="GlyCosmos" id="C4YTG0">
        <property type="glycosylation" value="4 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YTG0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05452"/>
    <dbReference type="HOGENOM" id="CLU_008523_11_2_1"/>
    <dbReference type="OMA" id="PLMFAGQ"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000289">
        <property type="entry name" value="Pheromone-processing carboxypeptidase KEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF190">
        <property type="entry name" value="PHEROMONE-PROCESSING CARBOXYPEPTIDASE KEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0053">Apoptosis</keyword>
    <keyword id="KW-0121">Carboxypeptidase</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000411908" description="Pheromone-processing carboxypeptidase KEX1">
        <location>
            <begin position="20"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="20"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="577"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="491"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="659"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="587"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="692"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="702" mass="78757" checksum="7A26B834D7E7ABB8" modified="2009-07-28" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTI8</accession>
    <name>C4YTI8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_05481</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTI8"/>
    <dbReference type="PaxDb" id="5476-C4YTI8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05481"/>
    <dbReference type="HOGENOM" id="CLU_079191_0_0_1"/>
    <dbReference type="OMA" id="MFCEKAT"/>
    <dbReference type="OrthoDB" id="10252587at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21696">
        <property type="entry name" value="GINS_B_Psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056783">
        <property type="entry name" value="PSF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24997">
        <property type="entry name" value="PSF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="9">
        <location>
            <begin position="48"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein PSF1 C-terminal" evidence="10">
        <location>
            <begin position="188"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ46929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="236" mass="27092" checksum="81F7C54CDB7654B5" modified="2009-07-28" version="1">MFGDTANKLILDAKRSSNLSAIPIYQSDLVKSIVRETNDLNKDAEYLVEEQEQLQETQDQENSKINQCQLFVTHLSMRRNKRCLLAYEKSRADKITEFCWLNIDPIETSTSSSTTSTNTNSNVNQSSTNNAVNPLTKNLSNYTTSLDMNNLNHHEQDFFKQYQDLIMEFKSSFEDIDLSGDLNPPTNIFIDVRVLKDGGEVTTEYGSFNLIKDSQFFVRKSDVERLIQQGYLEEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTQ3</accession>
    <name>C4YTQ3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Translocase of outer membrane 40 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_05548</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Channel-forming protein essential for import of protein precursors into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTQ3"/>
    <dbReference type="PaxDb" id="5476-C4YTQ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05548"/>
    <dbReference type="HOGENOM" id="CLU_042174_0_0_1"/>
    <dbReference type="OMA" id="TRFNYRW"/>
    <dbReference type="OrthoDB" id="19656at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000009">
        <property type="entry name" value="Mitochondrial import receptor subunit TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-0626">Porin</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ46994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="390" mass="42308" checksum="2678B3AB055648DB" modified="2009-07-28" version="1">MSQQINPPLGSTDIAKLSIPTLPQVTTEPPKQNGLWSSNPVFSYINDVYITINEHRKSLGLTNPGTIENLNKEVARDVFLGQYFFTGLRADLNKAFSMMPAFQTSHTLSIGSNVLPAYAFSALYATDDYFLQGNIDNDLSFSGRINYGWDKSNISKVTLQLAHGQPSMIQLEQDYQANDCSINVKTLNPNFLSGNEFSGVVVGSILQSLSSKLAVGLETMYSKQPLAPPDTAVSYVARYNAGNWIASAQLQAQGALIASFWRKVTDKVEAGLETQVAATMKQVADPLMGVGFEPVIEGQTTIGAKYEYRTAVFRGQLDSKGKISAFLEKRIMPTVSILFSGEINQFKNTSRLGLGLQFEAAGNEQLMLMQQGLVDANGNPIPGAPAPGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTV1</accession>
    <name>C4YTV1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 NT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_05597</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTV1"/>
    <dbReference type="PaxDb" id="5476-C4YTV1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05597"/>
    <dbReference type="HOGENOM" id="CLU_033548_0_0_1"/>
    <dbReference type="OMA" id="SSGYCYV"/>
    <dbReference type="OrthoDB" id="3365224at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039931">
        <property type="entry name" value="EEIG1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456:SF1">
        <property type="entry name" value="C2 NT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="45"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="256"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ47042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="517" mass="56840" checksum="D3765F6891D3FE16" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-11-01" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>P43066</accession>
    <name>ARDH_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>D-arabinitol 2-dehydrogenase [ribulose-forming]</fullName>
            <shortName>ARDH</shortName>
            <ecNumber>1.1.1.250</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ARD1</name>
        <name type="synonym">ARDH</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1993" name="J. Bacteriol." volume="175" first="6314" last="6320">
            <title>D-arabitol metabolism in Candida albicans: studies of the biosynthetic pathway and the gene that encodes NAD-dependent D-arabitol dehydrogenase.</title>
            <authorList>
                <person name="Wong B."/>
                <person name="Murray J.S."/>
                <person name="Castellanos M."/>
                <person name="Croen K.D."/>
            </authorList>
            <dbReference type="PubMed" id="8407803"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>D-arabinitol + NAD(+) = D-ribulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17389"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17173"/>
            <dbReference type="ChEBI" id="CHEBI:18333"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.250"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Carbohydrate metabolism; D-arabinitol metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.250"/>
    <dbReference type="EMBL" id="L16227">
        <property type="protein sequence ID" value="AAC37430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM000312">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P43066"/>
    <dbReference type="SMR" id="P43066"/>
    <dbReference type="PaxDb" id="5476-P43066"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05342"/>
    <dbReference type="UniPathway" id="UPA00380"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047038">
        <property type="term" value="F:D-arabinitol 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000240">
        <property type="entry name" value="SDR family oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF14">
        <property type="entry name" value="DEHYDROGENASE ARBD, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000054517" description="D-arabinitol 2-dehydrogenase [ribulose-forming]">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Lowers pKa of active site Tyr" evidence="2">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="L0E2Z4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="O93868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="281" mass="30643" checksum="B302A6411691F892" modified="1995-11-01" version="1">MDSAYWSYDNIVPSFRLDGKLVILTGGSGGLAAVVSRALLAKGADVALVDMNLERTQQAARDVLQWGEEQMKGKYESPIGQVSAWSCNIGDAEAVDLTFKAINEHHGKISSVLVNTAGYAENFPAEEYPAKNAENLMKVNGLGSFYVSQAFARPLIQNNMTGSIILIGSMSGTIVNDPQPQCMYNMSKAGVIHLARSLACEWAKYNIRVNTLSPGYILTPLTRNVISGHTEMKTEWESKIPMKRMAEPKEFVGSILYLASESASSYTTGHNLVVDGGYECW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCS5</accession>
    <name>C4YCS5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCS5"/>
    <dbReference type="PaxDb" id="5476-C4YCS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00309"/>
    <dbReference type="HOGENOM" id="CLU_1299537_0_0_1"/>
    <dbReference type="OMA" id="ITSRWES"/>
    <dbReference type="OrthoDB" id="4095724at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="224" mass="21753" checksum="7A1DB674F320372E" modified="2009-07-28" version="1">MPVQQRDLFSDINNIISAGVGVANTVASVGENVFVTLTSDAAGNWHKATSGVVVEFNTLTSKGAQEFHVVTSLADGKFSTVTKGVVSNWGEFTSEIESKKDSLTAAAAAASESAASTTGTETASTDSASGSASGSNSASGSSSTSGSGSASAASNGSSSTTAASSSTRSGSDSSSSTATSSRSSSSSSSTASGNAAPAVYQPGSWKKSAVVGGLIGLSFILSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCX5</accession>
    <name>C4YCX5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_00359</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCX5"/>
    <dbReference type="PaxDb" id="5476-C4YCX5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00359"/>
    <dbReference type="HOGENOM" id="CLU_010245_2_1_1"/>
    <dbReference type="OMA" id="HVVNLNA"/>
    <dbReference type="OrthoDB" id="10254721at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00692">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057:SF14">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ42161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="624" mass="71715" checksum="20E9F47BF165D0FB" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCZ1</accession>
    <name>C4YCZ1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glucoamylase 1</fullName>
            <ecNumber evidence="2">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_00378</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="2"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCZ1"/>
    <dbReference type="PaxDb" id="5476-C4YCZ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00378"/>
    <dbReference type="HOGENOM" id="CLU_000631_11_3_1"/>
    <dbReference type="OMA" id="WQPLNPL"/>
    <dbReference type="OrthoDB" id="1334205at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000001">
        <property type="entry name" value="Maltase-glucoamylase, intestinal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000005">
        <property type="entry name" value="Maltase-glucoamylase, intestinal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000138">
        <property type="entry name" value="Putative alpha-glucosidase AgdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000169">
        <property type="entry name" value="Putative alpha-glucosidase AgdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030459">
        <property type="entry name" value="Glyco_hydro_31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF133">
        <property type="entry name" value="P-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00707">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="14">
        <location>
            <begin position="92"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="15">
        <location>
            <begin position="527"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEQ42177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="742" mass="83554" checksum="A623B987C9DA4DE1" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD78</accession>
    <name>C4YD78_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase assembly factor FMC1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_00468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD78"/>
    <dbReference type="PaxDb" id="5476-C4YD78"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00468"/>
    <dbReference type="HOGENOM" id="CLU_128881_1_0_1"/>
    <dbReference type="OMA" id="HRVGFEL"/>
    <dbReference type="OrthoDB" id="15893at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039196">
        <property type="entry name" value="Fmc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28015">
        <property type="entry name" value="ATP SYNTHASE ASSEMBLY FACTOR FMC1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28015:SF1">
        <property type="entry name" value="ATP SYNTHASE ASSEMBLY FACTOR FMC1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ42264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="17867" checksum="3B6A82874DCFDD57" modified="2009-07-28" version="1">MSIFTKQFPNLKQLQKNITQELLKYENSTARSLSKAELEKTRTYYNYLKKVKLSKGEISAIKDIDTKLADLSKDKFQHQAELQNKSSLNGITENITNEKLPHEYKLNNLNNVHQYLKNQREYFELLTRYNPGLLMSQADNVSKTANKVGLEVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD97</accession>
    <name>C4YD97_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">triacylglycerol lipase</fullName>
            <ecNumber evidence="2">3.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_00487</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:12045"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the AB hydrolase superfamily. Lipase family. Class Lip subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD97"/>
    <dbReference type="SMR" id="C4YD97"/>
    <dbReference type="ESTHER" id="canal-LIP2">
        <property type="family name" value="Fungal-Bact_LIP"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YD97"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00487"/>
    <dbReference type="HOGENOM" id="CLU_029538_5_0_1"/>
    <dbReference type="OMA" id="WITGSAN"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.130:FF:000001">
        <property type="entry name" value="Lipase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944138" description="triacylglycerol lipase" evidence="13">
        <location>
            <begin position="17"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ42283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="466" mass="50406" checksum="1669404C2AECBFCB" modified="2010-10-05" version="1">MKGLVFLLGLLPTIYASLVHITPASEDDFYNPPAGFESAKNGDILKLRNSPNRLASFYFPIDVKNAWQLLVKSEDSFGNPNAFVTTLIEPYNADPSKVVSYQTWEDASNINCSPSYGAQFGSPLSTITTQIDMTLIVPPLRSGYYVVTPDYEGPKATFAVGRQSGQATLDSVRAILKSGSFSGINEDAKVALWGYSGGSLATGWAAALQPVYAPELQKNIVGAAVGGFAANITAIAESVDGTIFAGLITLALNGLANEYPDLKTAFYEELSDFAVPEFKAGAENCLAENIFHYPLHQYFTGPKRAFEKGWGLLKEDIFNKSIQDNLLIGLNKTYLPQVPVLIYHGTVDEIIPIKDPHAQYQLWCDWGIESLEFAEDLSTGHLAETFTGAPAALAWIDARFDGKTPIQGCSHTTRLTNLLYPNTSDSTHSYFLGIYQAVFGTPLGPGINGDNITINSGLLGLVSSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDA0</accession>
    <name>C4YDA0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5 6">2.5.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_00490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = N(6)-dimethylallyladenosine(37) in tRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 7">Belongs to the IPP transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5 6"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDA0"/>
    <dbReference type="PaxDb" id="5476-C4YDA0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00490"/>
    <dbReference type="HOGENOM" id="CLU_032616_2_3_1"/>
    <dbReference type="OMA" id="VPHYLID"/>
    <dbReference type="OrthoDB" id="775260at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030666">
        <property type="entry name" value="IPP_transferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF89">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039110">
        <property type="entry name" value="IPP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ42286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="465" mass="54211" checksum="2784F79514076A16" modified="2009-07-28" version="1">MLNKLYQLLAKSIIPNMSTKKPIISIVGTTGVGKSQFSIDLARAIGGEIINADSMQVYQKLDQITNKHPLDERMGVPHHVIDYVPWDEDYHIHKFNQDAQSVIDDIHNRGKIPIVVGGTHYYLQTLLFNNKTIDDSNSNLKELTAEQLEILDGPVDILFRTLQEVDPIIAKKFHPQDHRKLRRALEIFYTKGEKASEIYHEQKLDELDSSSLKYNTLFFWVYCDPEILNDRLDKRVDKMMENGAIEEIKEMYDFYKSKQEQNLTCTSGIWQVIGFKEFLLWLEDNQSDTKLFEHGIERMKIRTRQYARYQVKWIKKSLLTELEKESKFDFVNGGKLYILDATNLDNWHENVDDIGIQIAQDFLSKGANGVSLPQAPDELKHFFEAPNEIKSNRRLESQENWKHFVCDICKDKQGNALVAVGEDSWSVHVNSRRHKKNEESIKKRKHNEEMIRLKKMRSNQEGVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDK1</accession>
    <name>C4YDK1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DOM34-interacting protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_00596</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat WDR3/UTP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDK1"/>
    <dbReference type="PaxDb" id="5476-C4YDK1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00596"/>
    <dbReference type="HOGENOM" id="CLU_005318_0_1_1"/>
    <dbReference type="OMA" id="MNIPLTC"/>
    <dbReference type="OrthoDB" id="407922at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001139">
        <property type="entry name" value="DIP2p Nucleolar protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:003619">
        <property type="entry name" value="Uncharacterized WD repeat-containing protein C3D6.12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000178">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25173">
        <property type="entry name" value="Beta-prop_WDR3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25172">
        <property type="entry name" value="Beta-prop_WDR3_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="82"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="218"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="414"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="513"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="612"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="654"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="696"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="5">
        <location>
            <begin position="839"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ42387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="981" mass="110124" checksum="0BC082FAA2937A74" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDY1</accession>
    <name>C4YDY1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_00730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PET117 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDY1"/>
    <dbReference type="PaxDb" id="5476-C4YDY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00730"/>
    <dbReference type="HOGENOM" id="CLU_161486_0_0_1"/>
    <dbReference type="OMA" id="VHYVQEL"/>
    <dbReference type="OrthoDB" id="76305at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031568">
        <property type="entry name" value="Pet117"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163:SF1">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15786">
        <property type="entry name" value="PET117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ42517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="97" mass="10827" checksum="5EC9836E3B9EAA77" modified="2009-07-28" version="1">MSTASKITLGASCAFAVGAFVFINYSQQAERQALRQGPIKDAARQQAKQLEKSKKQLANELEHKEQTELREKYLKLQPLSDEIIKGEEGKIIPPKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YE44</accession>
    <name>C4YE44_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heat shock protein Hsp88</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_00797</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YE44"/>
    <dbReference type="PaxDb" id="5476-C4YE44"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00797"/>
    <dbReference type="HOGENOM" id="CLU_005965_5_1_1"/>
    <dbReference type="OMA" id="WEQSPEI"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000020">
        <property type="entry name" value="Heat shock SSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="652"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="652"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="662"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="674"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ42580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="702" mass="78654" checksum="AFA1A75892E779E3" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEE0</accession>
    <name>C4YEE0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_00897</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BMT family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEE0"/>
    <dbReference type="PaxDb" id="5476-C4YEE0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00897"/>
    <dbReference type="HOGENOM" id="CLU_013841_1_1_1"/>
    <dbReference type="OMA" id="LMTSRIF"/>
    <dbReference type="OrthoDB" id="3631276at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021988">
        <property type="entry name" value="BMT1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12141">
        <property type="entry name" value="BMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ42676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="654" mass="75752" checksum="F7D64784496F0ED8" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEF1</accession>
    <name>C4YEF1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_00908</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL54 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEF1"/>
    <dbReference type="PaxDb" id="5476-C4YEF1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00908"/>
    <dbReference type="HOGENOM" id="CLU_144297_2_0_1"/>
    <dbReference type="OMA" id="FMKWRRK"/>
    <dbReference type="OrthoDB" id="10252718at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013870">
        <property type="entry name" value="Ribosomal_mL54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L54, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08561">
        <property type="entry name" value="Ribosomal_L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ42687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="120" mass="13859" checksum="377223106B9FD2AC" modified="2009-07-28" version="1">MFRSIYRVTLKRASPIINTRQLTVSSIRFNETTTTTSTTTTTTPKSSCPAGTVLNLKVFKKGDEPVAKEDSEYPEWLWTMLDPKDNLKAIQNEDFLRWRRIKLSKENNSTIKNNNFLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEG2</accession>
    <name>C4YEG2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein SYG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_00919</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
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    </reference>
    <comment type="function">
        <text evidence="3">Core regulatory subunit of the histone H2A phosphatase complex, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF44"/>
    <dbReference type="PaxDb" id="5476-C4YF44"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01155"/>
    <dbReference type="HOGENOM" id="CLU_004909_4_0_1"/>
    <dbReference type="OMA" id="YHRYMIS"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010948">
        <property type="term" value="P:negative regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000455">
        <property type="entry name" value="Psy2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055236">
        <property type="entry name" value="EVH1_PP4R3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22972">
        <property type="entry name" value="EVH1_PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PP4R3 EVH1-like" evidence="7">
        <location>
            <begin position="28"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="6">
        <location>
            <begin position="169"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="527"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="838"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="968"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="542"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="555"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="838"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="862"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="969"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00058488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ42930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="993" mass="112354" checksum="C5E232C5D5462409" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF47</accession>
    <name>C4YF47_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_01158</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF47"/>
    <dbReference type="SMR" id="C4YF47"/>
    <dbReference type="PaxDb" id="5476-C4YF47"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01158"/>
    <dbReference type="HOGENOM" id="CLU_074922_1_2_1"/>
    <dbReference type="OMA" id="LTVYQHE"/>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03382">
        <property type="entry name" value="PAP2_dolichyldiphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039667">
        <property type="entry name" value="Dolichyldiphosphatase_PAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF59">
        <property type="entry name" value="DOLICHYLDIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="57"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ42933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="241" mass="27736" checksum="BF2DD0ACDEF3F579" modified="2010-10-05" version="1">MMLDYNPVPFDHTYILYDPNDIIAKICVQFSLLPIYLMVFYTSWFLITREIEPVIIVGGHLINELINKIIKVSIKSPRPDFHKNFGRDGGSYGMTYGFPSAHSQFMGFFAGYYICVILLKVPMPKSSKKPICLFAAISMMGVAFSRVYLLYHSNVQVIAGLITGVTLGIIYFIITSVARDVGLVEWILNWPIIKYFYVKDTYYHIYQTFAEEYEVYLQLRRERNEALLSAIIGNEKNSISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFM3</accession>
    <name>C4YFM3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_01341</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cell membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFM3"/>
    <dbReference type="PaxDb" id="5476-C4YFM3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01341"/>
    <dbReference type="HOGENOM" id="CLU_026724_0_0_1"/>
    <dbReference type="OMA" id="DTIFVAM"/>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ43104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="518" mass="58125" checksum="EF6D0933A6069A0E" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG18</accession>
    <name>C4YG18_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_00133</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="SMR" id="C4YG18"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00133"/>
    <dbReference type="HOGENOM" id="CLU_029499_3_0_1"/>
    <dbReference type="OMA" id="MPVPNWW"/>
    <dbReference type="OrthoDB" id="285674at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="5">
        <location>
            <begin position="4"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleotidyl transferase" evidence="5">
        <location>
            <begin position="178"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="6">
        <location>
            <begin position="334"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ41942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="458" mass="50817" checksum="9B356284F65485A6" modified="2010-10-05" version="1">MTLKVLILVGGETTGTRFRPLSMECPKLLFPLCGKPLVSHIIDNLTDQFPIDDLEILLMGFFKGQHKTMFQDYIQNVNKSNPDLRIKYLSEPFPLGTAGGLYHFKDEIFTDSNCKLLMIHGDVICNYPFKDMLEFFEQTKSNITLYGVDPVSLLKRSQAQILVVNGTENGDEAHDDDIVTKFGAIVAERKNSKVVHYVEKPSSSISEFRQDSTFEILLNGGIYIFDRSILDLLTSAEIKKKNSIQFDDGLDDNDSNDNDNSDNVLSLELDVFKTLPQLDNTNFNVFKSNGFWYQLKSPLSALLANNFFLAQSGGTKLSAGVELVQPVQILTESIAQAKSCKIGPNVSIGKNVTIGNGVRMVNCIVCDDVTIGDNTIIKNAIIANGTKIGKWCRIEGTITASILASNVISSSSAAYMKSLNDIVILCQNTVVHNQVFVYNSVVLPHKELKKDVKYEIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG98</accession>
    <name>C4YG98_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SANT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_00219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YG98"/>
    <dbReference type="PaxDb" id="5476-C4YG98"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00219"/>
    <dbReference type="HOGENOM" id="CLU_299559_0_0_1"/>
    <dbReference type="OMA" id="LFCEGFC"/>
    <dbReference type="OrthoDB" id="10258692at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000431">
        <property type="entry name" value="Set3C deacetylase complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051571">
        <property type="entry name" value="N-CoR_corepressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992">
        <property type="entry name" value="NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992:SF39">
        <property type="entry name" value="SMRTER, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANT" evidence="2">
        <location>
            <begin position="681"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="567"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ42022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1004" mass="112538" checksum="CDB4FA44B40CF303" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGB3</accession>
    <name>C4YGB3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_00234</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00234"/>
    <dbReference type="HOGENOM" id="CLU_013399_0_2_1"/>
    <dbReference type="OMA" id="QAWSRRI"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
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        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="5">
        <location>
            <begin position="154"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ42037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="530" mass="58687" checksum="8E7D1C046B6E0B18" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGD5</accession>
    <name>C4YGD5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_03111</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YGD5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03111"/>
    <dbReference type="HOGENOM" id="CLU_008002_1_0_1"/>
    <dbReference type="OMA" id="PLCKHHY"/>
    <dbReference type="OrthoDB" id="125856at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048625">
        <property type="entry name" value="Sec10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20667">
        <property type="entry name" value="Sec10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec10 N-terminal" evidence="7">
        <location>
            <begin position="53"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="6">
        <location>
            <begin position="177"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="57"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ44817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="785" mass="90551" checksum="FFC66D6E44586578" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGM4</accession>
    <name>C4YGM4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_03204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGM4"/>
    <dbReference type="PaxDb" id="5476-C4YGM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03204"/>
    <dbReference type="HOGENOM" id="CLU_083655_0_0_1"/>
    <dbReference type="OMA" id="DNRTENE"/>
    <dbReference type="OrthoDB" id="4026337at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944700" evidence="2">
        <location>
            <begin position="23"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="226" mass="26151" checksum="6DBADB2FC829FF63" modified="2009-07-28" version="1">MKPKLATAIKLISVLLLYPLECFPAIVPFRDSIELVFTPEDIKKSTDYALWKIPAVKKNFKTTVKQKLLNRLLNKDLQEINPNPYDEDIFEEQQQKVKANEISNTFQTVELDIKKPNGVMRSVLKGPSWTEKKQAKLVVQSTRNTLLKNNFNDNRTENEVKLELQELSGEHLGYSHPRRVKNIKHDFNKMPSEIHENVPDSDSDSEEDENQSGLQNEKPVDPFYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGP1</accession>
    <name>C4YGP1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_03222</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calmodulin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGP1"/>
    <dbReference type="SMR" id="C4YGP1"/>
    <dbReference type="PaxDb" id="5476-C4YGP1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03222"/>
    <dbReference type="HOGENOM" id="CLU_061288_2_0_1"/>
    <dbReference type="OMA" id="ARKMKEC"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000257">
        <property type="entry name" value="Calmodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000006">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="31"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="104"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="140"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ44923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="172" mass="19285" checksum="EA7FF4E5A421AE97" modified="2010-10-05" version="1">MKCVLSVRFYYLQQSFILTINFIKAEKLSEQQIAEFKEAFSLFDKDSDGKITTKELGTVMRSLGQNPSESELTDMINEVDVNSDGSIDFPEFLTMMARKMKDTDSEAEIAEAFKVFDRNGDGKISAAELRHVLTSIGEKLSDADVDQMIKEADTNNDGEIDIQEFTSLLAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGW0</accession>
    <name>C4YGW0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enhancer of mRNA-decapping protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_03296</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EDC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGW0"/>
    <dbReference type="PaxDb" id="5476-C4YGW0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03296"/>
    <dbReference type="HOGENOM" id="CLU_037134_0_0_1"/>
    <dbReference type="OMA" id="AMFDKKS"/>
    <dbReference type="OrthoDB" id="10030313at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10260:FF:000023">
        <property type="entry name" value="Enhancer of mRNA-decapping protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612:SF0">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DFDF" evidence="7">
        <location>
            <begin position="124"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="YjeF N-terminal" evidence="6">
        <location>
            <begin position="246"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ44992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="512" mass="57148" checksum="4CA94D1BDA5227A9" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGX4</accession>
    <name>C4YGX4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
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            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="356" mass="39272" checksum="B515B269D91BE01D" modified="2009-07-28" version="1">MSDIPPTNESNSDSTLINQKNNDNNDNNDNKETGKDISSTHTHHRVTFAEQQPISASSRKSSLLRKHSSNNTSSDSDKRPSIISRNSNPDIHRDSLPPLNRGPSYNGNYTRSHSSRNVNANNTINTGVTSDSNSNNNVDSNAPISSPTTPAISSPPANGKYFNLVLPAGKSREKSPGRHSKEGHTRSRSFTKQQHGIGSTSSQSSSQYLAQEKAYLRKMRNQSVDDYYSKGIPGAHEVSKADDNDDEDDEDEEHSSFDGGDNANLLAAIDDDKYQIDYSMALSLMKNSNVNLRKIANLNTDDTDDPAIIERLEWQSMLTSVLTGDVVRSEKTKIININNPDSTQESYLHATFKENL</sequence>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
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                <person name="Brunke S."/>
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                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
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                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
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                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
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                <person name="Silverstein K.A."/>
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                <person name="Sudbery P.E."/>
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                <person name="Lorenz M.C."/>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="295" mass="31006" checksum="125E1FC185257835" modified="2009-07-28" version="1">MNQLSNREPPKLPPGWKARWDEEYQTFFYINERTGETQWELPTEDATGTATHFESKNTVPSRPPVNQGNNDNEQTDRGIGSFVMNQAISSATGSKNHGSGGGGVQSFIMNQVVSSVTGSNKHHNGSGSGSGAAGLVGSLLSGGSSHNNNNNQQNQNQSSVGSLVGSLLSGGKSHGNGGNGSYNNHGGSYNDRPQQQQSGFSGASELIGNFLGGKNNHNNQGGGYNSGHNNNYGGGNNNYGGRNDNYGGRNDNYGGRNDNYGGRNDNYGGGYNNNNQGGFGTDNSFGYGGNNNNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
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                <person name="Grabherr M."/>
                <person name="Forche A."/>
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                <person name="Brown A.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHH7"/>
    <dbReference type="PaxDb" id="5476-C4YHH7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03523"/>
    <dbReference type="HOGENOM" id="CLU_1619339_0_0_1"/>
    <dbReference type="OMA" id="QYNTVKF"/>
    <dbReference type="OrthoDB" id="18412at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23024">
        <property type="entry name" value="zf-HIT_ZNHIT2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040722">
        <property type="entry name" value="Hit1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18268">
        <property type="entry name" value="Hit1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="3">
        <location>
            <begin position="5"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ45209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="145" mass="16565" checksum="5E2B5847AC3B38AC" modified="2010-10-05" version="1">MAVLCGICQVEQSKYKCPKCSIAYCSLTCYKSEIHTHDYLPTVTDTTSQPPQQQQQTTTTTPGDDRFSKLLQDDQIKYLLNQPSLQFHLLSIIKILIDPTFTPKNSNIEQKLDIANLKLNDLRIGGIEQNELVEEFVQRCLELMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHR9</accession>
    <name>C4YHR9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-alpha-acetyltransferase 30</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NatC catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_03618</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHR9"/>
    <dbReference type="SMR" id="C4YHR9"/>
    <dbReference type="PaxDb" id="5476-C4YHR9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03618"/>
    <dbReference type="HOGENOM" id="CLU_013985_0_3_1"/>
    <dbReference type="OMA" id="LCIFARH"/>
    <dbReference type="OrthoDB" id="249099at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000199">
        <property type="entry name" value="N-acetyltransferase catalytic subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="6">
        <location>
            <begin position="10"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00071796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00078622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ45301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="178" mass="21144" checksum="C7E1A04270350DEC" modified="2010-10-05" version="1">MSLITTINGLPYHQFDINNQDEFKQISNLISLHLSEPYSIYVYWYFLNNWPQYCYTVKEPETKKVIGVIISKIEPHRNVRMRGYIGMLVIDPKYRKQRLASNLVKLTIENMKSIDKVDEIMLETEVINQGALNLYESFGFLRTKRLYRYYLNTHDAYRLILPLGEKSRTRIAFLPPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHU1</accession>
    <name>C4YHU1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bud emergence protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_03643</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHU1"/>
    <dbReference type="PaxDb" id="5476-C4YHU1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03643"/>
    <dbReference type="HOGENOM" id="CLU_014957_0_1_1"/>
    <dbReference type="OMA" id="FICAHHN"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06890">
        <property type="entry name" value="PX_Bem1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11878">
        <property type="entry name" value="SH3_Bem1p_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11879">
        <property type="entry name" value="SH3_Bem1p_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035550">
        <property type="entry name" value="Bem1/Scd2_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035548">
        <property type="entry name" value="Bem1/Scd2_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035549">
        <property type="entry name" value="Bem1/Scd2_SH3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF2">
        <property type="entry name" value="SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="41"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="147"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="287"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
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        <location>
            <begin position="443"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
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        <location>
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            <end position="34"/>
        </location>
    </feature>
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            <end position="280"/>
        </location>
    </feature>
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            <end position="454"/>
        </location>
    </feature>
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        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="497"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ45323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="635" mass="72454" checksum="7F88C37C00D1A5D6" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI02</accession>
    <name>C4YI02_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YI02"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03708"/>
    <dbReference type="HOGENOM" id="CLU_1937857_0_0_1"/>
    <dbReference type="OMA" id="TTIEMMM"/>
    <dbReference type="OrthoDB" id="4026481at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="131" mass="15435" checksum="FD832C01428EDF7D" modified="2009-07-28" version="1">MMTSRKRTFEEFSTSHSFPFSEDTNSTRTNIFNCFPPSSPPPTATTSSSYDFYNTSMDDSSCGEKRFQKHKIHSEIHTTTIEMMMNAQLQLQRQEKLQRQQQQQPQQQQEEVKSDGEHNNGESTYHQRPYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI58</accession>
    <name>C4YI58_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Ornithine aminotransferase</fullName>
            <ecNumber evidence="4 9">2.6.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_03767</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2-oxocarboxylate + L-ornithine = L-glutamate 5-semialdehyde + an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:13877"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="EC" id="2.6.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="4 9"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI58"/>
    <dbReference type="PaxDb" id="5476-C4YI58"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03767"/>
    <dbReference type="HOGENOM" id="CLU_016922_10_3_1"/>
    <dbReference type="OMA" id="RSAWDLC"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:L-arginine catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000011">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000152">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ45440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="436" mass="47322" checksum="0E184FE9D9056F83" modified="2009-07-28" version="1">MSSTPDFKVSSETAREYETKYSAHNYHPLPVVFSKAEGAHVWDPEGKEYLDFLSAYSAVNQGHCHPKIVAALVDQASKLTLCSRAFSSDVFGVYAKYITEYFNYEMVLPMNTGAEAVETGLKLARKWGYDKKGIPSGEAIILSAVNNFHGRTLGVISMSTDPDATTNFGPYLRGVGPQIPGEPEGTLLRYGVIEDVEKAFANAGDKIAAILLEPIQGEAGIVVPPEDYLPKVQELCKKHNVLLICDEIQTGIARTGKMLCYEHSKGVKPDIVLLGKAISGGVMPVSAVLSSKEVMLTLEPGSHGSTYGGNPLACRVAIAALDVVRDENLVERAQKLGALLREKLEELQKESNGMISEVRGKGLLSAIVIDESKTNGRTAWDLCLLMKNHGVLAKPTHDNIIRLAPPLVISEEDLLKGVDSIRKSLKELPNVAKTEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIF6</accession>
    <name>C4YIF6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIF6"/>
    <dbReference type="PaxDb" id="5476-C4YIF6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04229"/>
    <dbReference type="HOGENOM" id="CLU_037642_0_0_1"/>
    <dbReference type="OMA" id="GIKDCLP"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012578">
        <property type="entry name" value="Nucl_pore_cmplx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28003">
        <property type="entry name" value="NUCLEOPORIN POM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28003:SF1">
        <property type="entry name" value="NUCLEOPORIN POM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08058">
        <property type="entry name" value="NPCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ45891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="531" mass="60845" checksum="FB4096C13CFEDAB2" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YII1</accession>
    <name>C4YII1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YII1"/>
    <dbReference type="PaxDb" id="5476-C4YII1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04256"/>
    <dbReference type="HOGENOM" id="CLU_933823_0_0_1"/>
    <dbReference type="OMA" id="VSHTNNE"/>
    <dbReference type="OrthoDB" id="4065319at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051009">
        <property type="entry name" value="PRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089:SF1">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ45916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="287" mass="31042" checksum="E31995C08C6D22F0" modified="2010-10-05" version="1">MNDNVVILTLRAANHITNAKRADSTTSTEAMPTLSDPNAYTTPSVSVPPNNNNPYIIRQSNPAGTVFIAVGAIVGAILLGFILYHLIVSLTASKLAKKSNADDRKLYEKYQSNNTNAYGYSGVTPQTSLNNFTSDYGGSVSKLPLLNKSFANVNGSQTGDNSTIYQSEVGAAVTSKHDLTKMFVSPTAEVMQHKRVRSSHYNPSLTNLSFGGSTSNLGNPSLATNRHSQAVPNLYINQEVNNSDYSLSQHGSVAPSSQQQQQQQQLNAPVNRKTLPSMYLEDLIDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YII3</accession>
    <name>C4YII3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Sulfiredoxin</fullName>
            <ecNumber evidence="4 14">1.8.98.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_04258</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin] + [protein]-dithiol + ATP = S-hydroxy-L-cysteinyl-[peroxiredoxin] + [protein]-disulfide + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17545"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="Rhea" id="RHEA-COMP:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:17976"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:61973"/>
            <dbReference type="ChEBI" id="CHEBI:61974"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="1.8.98.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the sulfiredoxin family.</text>
    </comment>
    <dbReference type="EC" id="1.8.98.2" evidence="4 14"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YII3"/>
    <dbReference type="SMR" id="C4YII3"/>
    <dbReference type="PaxDb" id="5476-C4YII3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04258"/>
    <dbReference type="HOGENOM" id="CLU_124532_1_1_1"/>
    <dbReference type="OMA" id="SQIRRPI"/>
    <dbReference type="OrthoDB" id="10023328at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032542">
        <property type="term" value="F:sulfiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16395">
        <property type="entry name" value="Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1530.10:FF:000005">
        <property type="entry name" value="Sulfiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1530.10">
        <property type="entry name" value="Conserved hypothetical protein from pyrococcus furiosus pfu- 392566-001, ParB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016692">
        <property type="entry name" value="Sulfiredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21348">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21348:SF2">
        <property type="entry name" value="SULFIREDOXIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017267">
        <property type="entry name" value="Sulfiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="ParB/Sulfiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB-like N-terminal" evidence="17">
        <location>
            <begin position="11"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="79"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Interchain" evidence="16">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR017267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR017267-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR017267-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ45918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="132" mass="14835" checksum="359C50934235289E" modified="2010-10-05" version="1">MSMYTSRLATEYVPLSEIKRPIPPVLDYQKIDAMLSTLKGVPMESATCKVEDITAGELPPIDVFKIRENGKNFYFAFGGCHRFQAYDRISKETEKEVMVKSRILPATRKSLRIYLGASVDALFDSVDSESSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIM6</accession>
    <name>C4YIM6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_04302</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIM6"/>
    <dbReference type="PaxDb" id="5476-C4YIM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04302"/>
    <dbReference type="HOGENOM" id="CLU_045151_4_0_1"/>
    <dbReference type="OMA" id="KYPPNIQ"/>
    <dbReference type="OrthoDB" id="4207594at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022023">
        <property type="entry name" value="U1snRNP70_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952:SF5">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12220">
        <property type="entry name" value="U1snRNP70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="122"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="243"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ45961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="349" mass="40634" checksum="D8015534F42E9A80" modified="2009-07-28" version="1">MNDNTEKYPPNIQKLFQPKPPFPYISPIDYPPEKRSTKPISPISSIKNEIDKYLTSELPERESKAQAVPKKISKIVKHKQKQHEANLKRLAKEKDHERQLEEWNNPTLFAKQEREFMKDPFRTVFIARLDYNLTELDISRAFARYGMIESIRIIRDKQGKSRGYGFVVYERNTDAMNCVNDLSRTGLKLGNRPILVDIERSRVLKNWRPRRLGGGEGGRGYVKEGKVQSVAASARRIVIANNPSFNTAPPQHDQQQFQYHHHQQQQQQQQHQPQFQTQYNTYTDFYQPQLSQRYSSGSRTASDVRAPATSIKDKYAKYSSIGTNPATEKTYSYKPASDDRSIRNIRRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIP7</accession>
    <name>C4YIP7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_04323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIP7"/>
    <dbReference type="PaxDb" id="5476-C4YIP7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04323"/>
    <dbReference type="HOGENOM" id="CLU_034207_0_0_1"/>
    <dbReference type="OMA" id="IYSCLCV"/>
    <dbReference type="OrthoDB" id="4023759at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ45982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="312" mass="36318" checksum="05A16F9D8EF4CA3F" modified="2010-10-05" version="1">MLLSHFMNINTVDSKVLTSSFSVDSSQEAQAFFQTGTKYLQESIDERKHLLQDNSGFGIERIIVNDLITFGCLLIYNHKLVPLISATGYDVISMAKAYSDTRKMYSQSMTGLRLESLFFPKSNPILTCPPETNYWFTRVLEFEIVAFVSRNGNKSANMEEYFQALMDTFLLLKDACYAMAIVRFPFPLIACLTNFSDKYRQLLRNGDEFAFRLLFIYSCLCVISRIPLNRNDNIFVDYISEFKNIIFSKYGEFSYPIDRELYHLVIRTNFVVDFGDMTRFHPLQQCEPLMDLSWLERYIDSLEKTNTLLQCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIQ4</accession>
    <name>C4YIQ4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="3 12">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_04330</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 12"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIQ4"/>
    <dbReference type="SMR" id="C4YIQ4"/>
    <dbReference type="PaxDb" id="5476-C4YIQ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04330"/>
    <dbReference type="HOGENOM" id="CLU_037146_1_1_1"/>
    <dbReference type="OMA" id="PGQVLGC"/>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11850:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ45989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="426" mass="48532" checksum="CB83F0C71E371E3E" modified="2009-07-28" version="1">MSPVEKPVEVEKPKVPKRRFVGKKPQNITIKDGEQPLTKTINPARHIGRVMNQIPDDILNDKELNEAIKLLPSNYNFEIHKTIWNIRKTNCKRVALQMPEGLLIYSLIISDILEQFCQVETIVMGDVSYGACCIDDYTARSLDCDFIVHYAHSCLVPIDITSIKVLYVFVTINIDETHLINTIKLNFERGTQIAIFGTIQFNPTIHSVKAKLENDTEKPMYLIPPQTRPLSKGEVLGCTSARLDKEHIKAMIYIGDGRFHLESSMIHNPEIPAYRYDPYSRKFTREYYDHKQMIDVRKDAISTTKYATKVGLILGALGRQGNPITLDKLEKSLSEKGIQVVKIILSEILPQKLAMFDDVDAFVQVACPRLSIDWGYAFNKPLLTPYEAMVMLEKDTMGDEKVYPMDYYSKDGYGRGSIPDHSHLTT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-12-14" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIU5</accession>
    <name>RU1C_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">U1 small nuclear ribonucleoprotein C</fullName>
            <shortName evidence="1">U1 snRNP C</shortName>
            <shortName evidence="1">U1-C</shortName>
            <shortName evidence="1">U1C</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">YHC1</name>
        <name type="ORF">CAWG_04374</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the U1 small nuclear ribonucleoprotein C family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ46030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIU5"/>
    <dbReference type="SMR" id="C4YIU5"/>
    <dbReference type="PaxDb" id="5476-C4YIU5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04374"/>
    <dbReference type="HOGENOM" id="CLU_146144_0_0_1"/>
    <dbReference type="OMA" id="YLTHDTM"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000890">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03153">
        <property type="entry name" value="U1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017340">
        <property type="entry name" value="U1_snRNP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148:SF1">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037969">
        <property type="entry name" value="U1_snRNP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000414285" description="U1 small nuclear ribonucleoprotein C">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="Matrin-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="150" mass="17248" checksum="F42746859441552A" modified="2009-07-28" version="1">MPKYYCDYCKSYLTHDTMSVRKSHLQGRNHIKFYCDYYEAKAKETNIWNPSSIPYEITLEKLNRYSDAKKSNGSSEDNMDIDKKENSSDHNKGNVVNHSDAGNDNDDDDDEMIFLPPPPNLSGLPLPTAAVYNNQKEYQKAILRQTLTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIZ7</accession>
    <name>C4YIZ7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Co-chaperone HscB C-terminal oligomerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_03809</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HscB family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIZ7"/>
    <dbReference type="SMR" id="C4YIZ7"/>
    <dbReference type="PaxDb" id="5476-C4YIZ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03809"/>
    <dbReference type="HOGENOM" id="CLU_068529_1_1_1"/>
    <dbReference type="OMA" id="TVELKYW"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.20">
        <property type="entry name" value="HscB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004640">
        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036386">
        <property type="entry name" value="HscB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009073">
        <property type="entry name" value="HscB_oligo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00714">
        <property type="entry name" value="hscB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021:SF15">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07743">
        <property type="entry name" value="HSCB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47144">
        <property type="entry name" value="HSC20 (HSCB), C-terminal oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Co-chaperone HscB C-terminal oligomerisation" evidence="4">
        <location>
            <begin position="124"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="124"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ45481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="209" mass="24356" checksum="08A89E9817A1EE21" modified="2010-10-05" version="1">MITRLIGIAKSGIYRTYSTASFYELFPKNFPHGGPPQDSFIVNDKSLRREYRSLQSESHPDISSDTIKSSNINRAYTTLKNPYTRIAHFIHLKSPNHVNITDDAVAKKLIKNYQQKSMEASMNYKEMLMQVMEAHEQLELAESENELETLEAENKERIKTTEERINQSLKNTPIDWEELMMDAIRLKYWVNIQNGIKDWEPGKPVHLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ64</accession>
    <name>C4YJ64_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_03876</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ64"/>
    <dbReference type="PaxDb" id="5476-C4YJ64"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03876"/>
    <dbReference type="HOGENOM" id="CLU_008279_12_1_1"/>
    <dbReference type="OMA" id="PMHGHYV"/>
    <dbReference type="OrthoDB" id="27652at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02663">
        <property type="entry name" value="Peptidase_C19G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000131">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="19"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="178"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="617"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="676"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ45548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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                <person name="Sakthikumar S."/>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:growing cell tip"/>
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        <property type="project" value="TreeGrafter"/>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="CENP-Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ45701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="252" mass="29229" checksum="A8ED256A851D1E0E" modified="2009-07-28" version="1">MTDDSATPASKKRKLTFDNEILNPLNFQPMINKQKISTAVIEKFWQPLDSVNSQSMDNIMNVALLKTLDESHSKVSRSITNVWFNSANPESFKSRLSQTKLPPPSSMYSSKLRIRANEVADVLSYDSLKRKRTVLETYLSAELKQLQELENHYNQSLLAYKSDLEYLKKFKSTVKNNESKYNEELERKREELNLSVQNKNPDDIYLLSTDNDFDPETDDDTKFILETIQENLFQSKLKNLNDKLEVLCNVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJQ9</accession>
    <name>C4YJQ9_CANAW</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
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                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04078"/>
    <dbReference type="HOGENOM" id="CLU_953155_0_0_1"/>
    <dbReference type="OMA" id="KERNTDN"/>
    <dbReference type="OrthoDB" id="4013630at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="292" mass="33729" checksum="0CC8C452D6546AAF" modified="2009-07-28" version="1">MFIQDTITRYPYCAVNLSASLLLGVTHFLRRDYNLVLLTAWNLLIVLYTPIQILNLNNSLVCDSQIALTFLTSIVISYSILKEENRKSLFSRYTYVLSFIIILIFVVVIIPDRMMLNSISTIYDRIKFDHIYIVLTLIYVVDAITKFAFTSDFTSILIQGIWTYNSIVIIISMWFIIYSKDTLFSILKIIEQDDSQNTSFVTSFIISSISQLEEDYQLCSQGKTALEMCLKERNTDNLQSYFIILKTMVTNCWSILNLVSFVLIPTLISCIYNRKQLLSNIKQFEAKADSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJS0</accession>
    <name>C4YJS0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_04089</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YJS0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04089"/>
    <dbReference type="HOGENOM" id="CLU_035625_2_0_1"/>
    <dbReference type="OMA" id="FTINMIK"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051643">
        <property type="entry name" value="Transcr_Reg_ZincFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24396:SF19">
        <property type="entry name" value="FI01119P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24396">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="89"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="137"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ45754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="376" mass="42414" checksum="EB7C7720D2BB1BF2" modified="2009-07-28" version="1">MLSMAVTPSNTLTSQYPTKQENYNQNYCSIKSPSPTSTPTSTSLTMTSPPQLHNPHASITLPSIHSLDIPAFPHYEQEYSRASVFQNYSSNSPTPSNSSYSPTLLIPSNDRPASSSVYSNSSSTLLLSPGMSTTPNVNCIAPVSRPRSTSNLTENSEQSFTSQQSHPAISSNATITSPQLSVKSENEQLHEPQNSNTIISPRQNKKNWKPRKKKQCPECNLYFSNLATHKSTHLKPNNRPHICKYCERGFARPNDLFRHVKCHWKEIGSDQGQFKCPFKNIDSSKRENQEKVTGNTGVPDHCCHNTGIFSRCDTFKNHLKAIHFQYPNGTKKEQRNLVNGKCRMCQQEFRNVDDWMHNHIETNSCPYAINLIKKEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK55</accession>
    <name>C4YK55_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK55"/>
    <dbReference type="PaxDb" id="5476-C4YK55"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05851"/>
    <dbReference type="HOGENOM" id="CLU_100674_2_0_1"/>
    <dbReference type="OMA" id="GEPCHED"/>
    <dbReference type="OrthoDB" id="2014058at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008699">
        <property type="entry name" value="NDUFB8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE ASHI SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05821">
        <property type="entry name" value="NDUF_B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="211" mass="23565" checksum="E67794E7F2BB9191" modified="2010-10-05" version="1">MISRIGLRTPAKVLSLSSRGVAGYTSRIALTRSYATQKATIYDQSTGQTIELADPEHPELADFKNPPFVLKQYLDPYAKYDDPQNRRNKNDPMHIDEDMLDLWSPDYYDHVSDSTALKHNAIFFGLIFGISAVIAYFQLNPEKPAMIRSFPYNGLADALGATSEETAPFYQNKPDLTAEKECGILPADNDITNNQAAYKKENSEFIKSGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK81</accession>
    <name>C4YK81_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_05878</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK81"/>
    <dbReference type="PaxDb" id="5476-C4YK81"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05878"/>
    <dbReference type="HOGENOM" id="CLU_010226_0_1_1"/>
    <dbReference type="OMA" id="QWSMGIV"/>
    <dbReference type="OrthoDB" id="5212126at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF2">
        <property type="entry name" value="FLAVIN CARRIER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944277" description="ML-like domain-containing protein" evidence="8">
        <location>
            <begin position="23"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="596"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="9">
        <location>
            <begin position="24"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ47310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="718" mass="80521" checksum="8617A47C89B984B0" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKP6</accession>
    <name>C4YKP6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_06052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKP6"/>
    <dbReference type="PaxDb" id="5476-C4YKP6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06052"/>
    <dbReference type="HOGENOM" id="CLU_539235_0_0_1"/>
    <dbReference type="OMA" id="EMRNTIM"/>
    <dbReference type="OrthoDB" id="4095887at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ47475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="505" mass="59743" checksum="6BB5E48F86DAC498" modified="2009-07-28" version="1">MEKKRSPIQITRSLNQIMITRKPYRIRSFINRSYSITRNPSKINRNISTHDRSTTNVLKRNQRRLKEFENNIQLAEQFKTHRQNVVEILKDEKNIDALFEKEVPIIVNDYEKLTEEMGALSFNDIEMRNTIMLVCHSLVESMYIELTLSKLEDKRIKPYLEEIKSSHWFESLAEYRFRFYNFKSSQFLSSTESDMSTQVNGNNFVRFNSCQKNSHEYIKKFERSFEKYKKAQNEPMSHIQLATNLVQDLLCTHEYIPTTEIWHYLLRNLGTLKLYNYQQIIYLSLFQYKHQPTILATPKEQDRLTAPLMADHFSHLIEDFPEILSTLCQYQEVRKDKRTFIELLSFLKLDKLAGEVMAIKSPLLSKAKYKLPAICPGIELECKDLFISRDCLYSIMKSAINLELYEYVDLLYDKIVLDSIDPYRIQLNYEEKRLVEGSIFTPELFLIMLEACKKSKDLGRVLWLMPFLDEYVGKNSVPVTLKNSILEVLKTFNLEGKLVSYQKIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLU4</accession>
    <name>C4YLU4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_01813</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLU4"/>
    <dbReference type="PaxDb" id="5476-C4YLU4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01813"/>
    <dbReference type="HOGENOM" id="CLU_028276_0_0_1"/>
    <dbReference type="OMA" id="DYWCAYD"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000033">
        <property type="term" value="F:alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392:SF1">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ43575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="707" mass="82495" checksum="F22701E3A28DE9D9" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLW9</accession>
    <name>C4YLW9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_01841</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLW9"/>
    <dbReference type="SMR" id="C4YLW9"/>
    <dbReference type="PaxDb" id="5476-C4YLW9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01841"/>
    <dbReference type="HOGENOM" id="CLU_025709_4_0_1"/>
    <dbReference type="OMA" id="HSGHLRW"/>
    <dbReference type="OrthoDB" id="10263554at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032184">
        <property type="entry name" value="ATPase_V1_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="6">
        <location>
            <begin position="343"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR032184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ43600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="469" mass="53379" checksum="6437FA3DF583A5C3" modified="2009-07-28" version="1">MSEGYTPLVIDSTFLFDSKKIIKERIIPWEGLARSGVVSEDDANHIKLLEKQSIENRNNTVKAQLDLYSKCLLNVLNRVDSKDDVLKNILALINDLLLDVPEFLDAVLKLSEVDKSLPYIPFINHLDNKDNLIKSLSLYNLEILLGKVKTINDDEILIKIFSVLSYLIGESADSNYQFIGVQLLQDLLIVKPFKLVYQNNNLLTNFKPINNLIEKSAKNPNSIGLQLSYNVLLVVWVLSYTAPINRSLIHNFPQLVGNLLSIAKDSIKLKIVRVAVAILKNFVDITISSQEQFKVIKVLLFSDALNTVNTLKERKFASNGSDEELSNDLNYLYDNLQEIVTQKLTSFDEYLTELENPKLISWASPTHKSTEFWLENSGKFKDSNYKLVKRIFEILISNTNDSTTINVILLNDLQFLIKNLGKDLITFINTEKGGQYKLLIMTFLDNSQGDNELKYQALKTIQLLVGHNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM30</accession>
    <name>C4YM30_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM30"/>
    <dbReference type="SMR" id="C4YM30"/>
    <dbReference type="PaxDb" id="5476-C4YM30"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01905"/>
    <dbReference type="HOGENOM" id="CLU_1320722_0_0_1"/>
    <dbReference type="OMA" id="PMAYAIR"/>
    <dbReference type="OrthoDB" id="3548492at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23907" checksum="FD4E0E66DCC107A0" modified="2010-10-05" version="1">MNMNIGSHRDESVSTNPNSLHMQFFQDDPDQIAPVHLDPTSMIVNRVTINTLEEQSTNPKIFEDNQDNDESDKYSEDKLDPIAFSIRNRKFKAELTPDERGYIIGRSVSTSVQELAKELKLSRSTIQHTLKMCRQRKHNKTLNQNRGRKLAISPEEMERVLKLIEQRPGISKQEIISSLDLKVSSRTLARALQRNGTKRLTSRNHGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM54</accession>
    <name>C4YM54_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Adenylosuccinate lyase</fullName>
            <shortName evidence="12">ASL</shortName>
            <ecNumber evidence="6 12">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_01930</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = fumarate + AMP</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="6 12"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM54"/>
    <dbReference type="PaxDb" id="5476-C4YM54"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01930"/>
    <dbReference type="HOGENOM" id="CLU_030949_1_1_1"/>
    <dbReference type="OMA" id="VQENAMK"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03302">
        <property type="entry name" value="Adenylsuccinate_lyase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.60:FF:000001">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000005">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="13">
        <location>
            <begin position="374"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ43685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="482" mass="54411" checksum="FE6E0821F203FDE1" modified="2009-07-28" version="1">MSEYDKYSTPLSSRYASEEMSKIFSLRNRFSTWRKLWLNLAIAEKEVGLSVITDEAIEQMKQHLEITDKEIQDAAVEEAKVRHDVMAHVHVFGETCPSAAGIIHLGATSCFVTDNADLIFLRDAYDVLIPKLVNAIDRLSKFALEYKDLPVLGWTHFQPAQLTTVGKRATLWLQELLWDLRNMVRARNDIGLRGVKGTTGTQASFLSLFHGDHDKVEELDKRVVELLGFDIVYPVTGQTYSRKIDIDVLSPLASFGATAHKFATDIRLLANLKEIEEPFEKSQIGSSAMAYKRNPMRCERVCSLARHLGGLFNDAVQTASVQWFERTLDDSAIRRISLPSAFLTVDILLSTMLNITSGLVVYPKVIERRINSELPFMATENIIMAMVEKGGSRQDCHEEIRVLSHQASAVVKQEGGDNDLIERIKSTKYFKPIWNDLDTLLDPKTFVGRAPQQTEKFVKNDVANALKPFEKYITTENVALKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM85</accession>
    <name>C4YM85_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein ICE2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM85"/>
    <dbReference type="PaxDb" id="5476-C4YM85"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01963"/>
    <dbReference type="HOGENOM" id="CLU_027878_2_0_1"/>
    <dbReference type="OMA" id="TTPDRSW"/>
    <dbReference type="OrthoDB" id="5577218at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048309">
        <property type="term" value="P:endoplasmic reticulum inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013635">
        <property type="entry name" value="Ice2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31726">
        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31726:SF2">
        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08426">
        <property type="entry name" value="ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="54759" checksum="7F3F92614A1584BB" modified="2009-07-28" version="1">MPIIKTITRSIRAILATLYLVLIILTIPLAFDVGGVNCGLAYSLTTLVTYFILTTIRILVRKTKYFQWISIIYYCQHFFIPSLLTYFLSYYSHENIKKLDLISSSGSGSSTSTSTSSKFNPVMIWRLVLINSTPIFTVLEGFCSLLLIQAMGQTMSWLTIYKSDSWLIISLIGSGSVITASFYFLYRIYVLPFTIDMFSASLLGSILTTTMGLGLFGIISGKGSMIESSLLFAYIVKCIYETFPILSEAATKALANLFTLTTQNLKKEIPKIPPSILNPISEVIPFITSTLPSSFKGVWKFLIMAIKTLTLPLLLNLAYRIGVFYAATKIIPSLYQSASYPLITPPKTPQPGSRQVSTTSLSTFTSSTTSTVLDQHSKLRTKNSFRLKPPHHQPPSVIIRLIYAYSPCLIIAVYTHLMLSYNGELGTELKLWPLWNSSNGGGGGDDIQLIVHPWQFWNWINMGTTLILYAAELSSNDNSSGGGNSLTSHWKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMI1</accession>
    <name>C4YMI1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HIRA-interacting protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_02063</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMI1"/>
    <dbReference type="PaxDb" id="5476-C4YMI1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02063"/>
    <dbReference type="HOGENOM" id="CLU_060555_0_2_1"/>
    <dbReference type="OMA" id="MAAHVRW"/>
    <dbReference type="OrthoDB" id="565552at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000001">
        <property type="entry name" value="NifU-like protein 4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035433">
        <property type="entry name" value="NFU1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036773">
        <property type="entry name" value="HIRIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="3">
        <location>
            <begin position="34"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ43812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="262" mass="29477" checksum="4274170830800407" modified="2009-07-28" version="1">MFTFTRNIPRSLLHYTPITKRTPLITTTIRNLFIQTSETPNEQALKFLPSIKILQDNQTKEFLSGREAASSPLALKLFSIDGIRSVMFGSDFITIEKSNNFDWSLLKPEIFSILTEYLTNGTPILLEDNVDEYGNSLLTNDMAINEDDDEVVSMIKELIFTRIRPAIQDDGGDIEFVNFNEEDGTVYLRLKGACRSCDSSSVTLKNGIESMLKHYIEEVNSVESIEEEEQQEEINVESSTINPINRDEPSSSVSSSSSPPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMQ0</accession>
    <name>C4YMQ0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-glycosylation protein EOS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMQ0"/>
    <dbReference type="PaxDb" id="5476-C4YMQ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02134"/>
    <dbReference type="HOGENOM" id="CLU_043059_0_0_1"/>
    <dbReference type="OMA" id="HIWIFIS"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021100">
        <property type="entry name" value="N-glycosylation_EOS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28147">
        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28147:SF1">
        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12326">
        <property type="entry name" value="EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02070">
        <property type="entry name" value="NGLYCOSEOS1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="423"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ43881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="52075" checksum="D66B10D7995B7631" modified="2009-07-28" version="1">MVFISTLLSSSLGSRFSNTLESHQIDDDYSEQYDFDTVESSSSSSSLPQSQRQVSSTNLSSGLSSYPDRRVITETTAATATINASNFSSPPSPPRQSLASTPTQPSNCVAVADIDTRFPPSSAVINQYDPYEEVPSYEASQRMHNQSANSNSNNNSSSSSNIAHNNDNYIAEDVSHIAPTTHIYTPIPSLPIPITSSTTGISYGNSYDALINNNNNNNNGNTSNSNNNNRNGNNSSNGNASNSTLRGGNIKRSSIKQLGLKFLNARQHFLLASCRDVSLIPPLIGLIRSWRMIYSNDANNYNQALNGDGVTLIRGSEHFLTGLWCIVAGYLSYSILDSLLVRWIMTYSTSAAIVRVLSMSTIIITIELYLINTTSAITDYGLHIWIFISCVLTFTYIVQNFVTSNLELINYYKRTTIHKRARFFDFYNIVVFAVVPVGLASFVTMVGLLRSLLLLRIEIDSNNNGNDMINLDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN22</accession>
    <name>C4YN22_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SAGA complex subunit Spt7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_02262</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="C4YN22"/>
    <dbReference type="PaxDb" id="5476-C4YN22"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02262"/>
    <dbReference type="HOGENOM" id="CLU_006198_0_1_1"/>
    <dbReference type="OMA" id="YRRSEAK"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Bromo_SPT7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HFD_SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcriptional activator spt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037782">
        <property type="entry name" value="Spt7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="428"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="67"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="188"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="526"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1180"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1224"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="585"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="604"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1184"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1227"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1258"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1273"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1298"/>
            <end position="1307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ44003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1307" mass="149239" checksum="02D97913B9E886D4" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN58</accession>
    <name>C4YN58_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_02298</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays a key role in the late stages of endoplasmic reticulum to Golgi traffic.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit TRAPP (transport protein particle) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="SMR" id="C4YN58"/>
    <dbReference type="PaxDb" id="5476-C4YN58"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02298"/>
    <dbReference type="HOGENOM" id="CLU_073154_2_1_1"/>
    <dbReference type="OMA" id="YMVKFDD"/>
    <dbReference type="OrthoDB" id="10254842at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000033">
        <property type="entry name" value="Trafficking protein particle complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017479">
        <property type="entry name" value="TRAPP_I_complex_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ44039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="248" mass="27709" checksum="56B4A9F15E0AC137" modified="2010-10-05" version="1">MSNDDIILPSVSSLSKLTINDVSKSGFGYNPSIGPISNTITLESSSVLLNKRTISLTPTSSDSIYDRNIITKKPHEINLSSLSFLFCEIISWAHSNSKGIQDLENRLNGLGYQIGQRYLELCKIREGFKNSKREIRLLEMLQFIHGPFWKLIFGKTANELEKSQDLPNEYMIVENVPLLNRFISIPKEYGDLNCSAFVAGIIEGALDNSGFNADVTAHTVATDANPLRTVFLIKFDDSVLIRESLRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YND3</accession>
    <name>C4YND3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_01392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YND3"/>
    <dbReference type="PaxDb" id="5476-C4YND3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01392"/>
    <dbReference type="HOGENOM" id="CLU_086411_0_0_1"/>
    <dbReference type="OMA" id="YILEIPV"/>
    <dbReference type="OrthoDB" id="4081031at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="258" mass="29459" checksum="2A6D6FC512DC1EB9" modified="2009-07-28" version="1">MSDAVEKVKQAVKPQQHFKSITIEHVYHYSFIEYITQYLLSFQIVNSIYKSFVLPLIDFVNVNIFSVSPIFDLLSFVDQLVNSGLVTFDKYILEIPVQTINSFGKTYVTPVENKLINLNNKYLNTAIEVKTRSEGEFYKVVETVQQVLINLKNFTFNKSIEIQQDLVATYNKELQSTDPKGNLIGKNLQASYNTASKTINKLNDDYLTPLKNQTQDYVDQFATQTKQRADEFINDAKQKVSPKLNELKESAPIVSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNG3</accession>
    <name>C4YNG3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Acetyl-CoA carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CAWG_01423</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP = N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11308"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YNG3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01423"/>
    <dbReference type="HOGENOM" id="CLU_000395_5_2_1"/>
    <dbReference type="OMA" id="PTPKGHC"/>
    <dbReference type="OrthoDB" id="14612at2759"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.460.10:FF:000001">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000005">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000010">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.460.10">
        <property type="entry name" value="Biotin dependent carboxylase carboxyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1770.10">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049074">
        <property type="entry name" value="ACCA_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21385">
        <property type="entry name" value="ACCA_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0092">Biotin</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="18">
        <location>
            <begin position="98"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="256"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="16">
        <location>
            <begin position="734"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="19">
        <location>
            <begin position="1527"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="20">
        <location>
            <begin position="1865"/>
            <end position="2180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="2210"/>
            <end position="2237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EEQ43196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="2271" mass="253282" checksum="A5D787B947AC3F5E" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNH8</accession>
    <name>C4YNH8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">M-phase phosphoprotein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNH8"/>
    <dbReference type="PaxDb" id="5476-C4YNH8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01439"/>
    <dbReference type="HOGENOM" id="CLU_151464_0_0_1"/>
    <dbReference type="OMA" id="FSINIRC"/>
    <dbReference type="OrthoDB" id="4084022at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10175">
        <property type="entry name" value="MPP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="15060" checksum="199136C6591F9045" modified="2010-10-05" version="1">MSTGLSNRVMNMKFMQKAEDSKLGKQKLEEQKKIHDLSEWVLPDSAKLLKLAAMKPKIDRVGFGTIMTNGNYNYSSTTKRSWGSNVSFEEIKDDDSNNVEDNDDEPLDLNTMWRKRKLESPSNSNKKKRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNL8</accession>
    <name>C4YNL8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_01481</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNL8"/>
    <dbReference type="SMR" id="C4YNL8"/>
    <dbReference type="PaxDb" id="5476-C4YNL8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01481"/>
    <dbReference type="HOGENOM" id="CLU_097982_0_1_1"/>
    <dbReference type="OMA" id="HQTYDLC"/>
    <dbReference type="OrthoDB" id="6409159at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00917">
        <property type="entry name" value="PG-PI_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000004">
        <property type="entry name" value="Phosphatidylglycerol/phosphatidylinositol transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033917">
        <property type="entry name" value="ML_PG-PI_TP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF0">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL_PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946672" description="Phosphatidylglycerol/phosphatidylinositol transfer protein" evidence="8">
        <location>
            <begin position="22"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="9">
        <location>
            <begin position="66"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ43251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="192" mass="21197" checksum="F2E54ED6442788EF" modified="2009-07-28" version="1">MVSFKNLAIVTLAVTTTSVEGISFSNIYLNKAITIFKNPTSLIPSFSNSKLINYQNTKPIPGDSPIEVCDASEKQLLHLDEVIVTPNPPVAGQNLTFTAVGTLDKTIEEGAYVEVEVRYGFIKLIHQTYDLCEEIVKVDLQCPIKSGKQTITKNVEIPEEVPPGKYLVVARAYTKDDEYITCLTATIIFPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNL9</accession>
    <name>C4YNL9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cwh43p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_01482</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNL9"/>
    <dbReference type="PaxDb" id="5476-C4YNL9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01482"/>
    <dbReference type="HOGENOM" id="CLU_009808_0_0_1"/>
    <dbReference type="OMA" id="CVWYFPL"/>
    <dbReference type="OrthoDB" id="68581at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000031">
        <property type="entry name" value="Calcofluor white hypersensitive protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057315">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051916">
        <property type="entry name" value="GPI-anchor_lipid_remodeler"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053912">
        <property type="entry name" value="PGAP2IP_TM_1nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053911">
        <property type="entry name" value="PGAP2IP_TM_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859">
        <property type="entry name" value="CALCOFLUOR WHITE HYPERSENSITIVE PROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859:SF1">
        <property type="entry name" value="PGAP2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23022">
        <property type="entry name" value="6TM_1st_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23021">
        <property type="entry name" value="6TM_2nd_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23226">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNase I-like"/>
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            <end position="56"/>
        </location>
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            <end position="112"/>
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        <location>
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        </location>
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            <end position="321"/>
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            <end position="402"/>
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    </feature>
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        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="446"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="484"/>
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    </feature>
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            <end position="660"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="1005"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ43252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1020" mass="115829" checksum="EDC76F91A06EAFD4" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNS2</accession>
    <name>C4YNS2_CANAW</name>
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        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_02855</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12 13">WO-1</strain>
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    </reference>
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        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:29999"/>
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            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
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            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
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        </reaction>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF137">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="181"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="427"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
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            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="78"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="438"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ44581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="580" mass="65757" checksum="DD96B4C1CC037AD8" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP59</accession>
    <name>C4YP59_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein phosphatase PP2A regulatory subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_03001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YP59"/>
    <dbReference type="PaxDb" id="5476-C4YP59"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03001"/>
    <dbReference type="HOGENOM" id="CLU_015533_2_1_1"/>
    <dbReference type="OMA" id="NRVEAMQ"/>
    <dbReference type="OrthoDB" id="340346at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000062">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit A alpha isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="49"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="259"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="4">
        <location>
            <begin position="298"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="299"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="343"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="4">
        <location>
            <begin position="376"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="382"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="421"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="612"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ44718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="643" mass="73033" checksum="9F87ADF26E62EF0C" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP82</accession>
    <name>C4YP82_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_03028</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YP82"/>
    <dbReference type="SMR" id="C4YP82"/>
    <dbReference type="PaxDb" id="5476-C4YP82"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03028"/>
    <dbReference type="HOGENOM" id="CLU_011276_8_5_1"/>
    <dbReference type="OMA" id="PTGCKLT"/>
    <dbReference type="OrthoDB" id="1721126at2759"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.110">
        <property type="entry name" value="Siroheme synthase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3280.10">
        <property type="entry name" value="Siroheme synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330:SF1">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="7">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="6">
        <location>
            <begin position="192"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ44741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="285" mass="33165" checksum="5B6A16A89D3897BD" modified="2010-10-05" version="1">MSSSETSEIKGSLLLAWQVKDKHCLVIGAGDVALSRIHHLIKAQAKITVVTGASKIHPQIIELNNQGKLYNFFQRDYQSNDLTIYENINSRINDLDLINSENYNLIDQQVYQEMFAVVCCCIDDYELSTKIYYQCKYLRIPVNIADKPPLCDFYFGSMINQDNLQIMISTNGKSPRLSRMIKDNISKEFENVNLNQAVENLGLIRSRLREMILIDDDLNTIDTRMTWIKNLTDFFTLKQWSEINLIPPSSTPPYDNRFQYVDNIINYFPDYPPKDYEEFKDAIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPA1</accession>
    <name>C4YPA1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="3 11">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_03050</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="3 11"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPA1"/>
    <dbReference type="SMR" id="C4YPA1"/>
    <dbReference type="PaxDb" id="5476-C4YPA1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03050"/>
    <dbReference type="HOGENOM" id="CLU_008255_6_0_1"/>
    <dbReference type="OMA" id="DFRNEGM"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000050">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000044">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="249"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ44760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="594" mass="67708" checksum="2D7AC1C6C9EDFBB5" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPE3</accession>
    <name>C4YPE3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTI2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPE3"/>
    <dbReference type="PaxDb" id="5476-C4YPE3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03096"/>
    <dbReference type="HOGENOM" id="CLU_855292_0_0_1"/>
    <dbReference type="OMA" id="AWFLIDY"/>
    <dbReference type="OrthoDB" id="6417021at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110078">
        <property type="term" value="C:TTT Hsp90 cochaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018870">
        <property type="entry name" value="Tti2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10521">
        <property type="entry name" value="Tti2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="354" mass="40227" checksum="0A8E72152A2873FC" modified="2009-07-28" version="1">MFCGYGNPWEMIVDSKETTGRFSNSACLTSCDIRKSDRFIVDKEDHRKNNHQKNFFFTMTFLDTTPSYELVHYLSLNANPNLPGSTPENVQQIMSSFDYHPYIPQLIRDFKASSKKVKQKNLVEDLGVLSQAWFLIDYAYSQEICILSMLLVEDVLTTYSVSAKIQAFNLLSHLPELNQPLIPQLRSAASKCLVHVPPITPLDESLRLLAQAYEWVYKLNTTTTDFIQTVAAILSTINTPARPFLLQQLSKYTRHLSTDVFISTSKIFYALNQILVSLDATPNEIVTALTIQHDIINLNHPFIATYAYDFIGAWSILSKHHPGKFSAQLQLNISSLQKLANNDDIDKLCTYINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPE8</accession>
    <name>C4YPE8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mannose-1-phosphate guanyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPE8"/>
    <dbReference type="PaxDb" id="5476-C4YPE8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03101"/>
    <dbReference type="HOGENOM" id="CLU_3362177_0_0_1"/>
    <dbReference type="OrthoDB" id="1733332at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="36" mass="4002" checksum="B05B742D74EE756B" modified="2009-07-28" version="1" fragment="single">VLGDDVEVKNEIYVNCAKVLPHKSISSNVEKESIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPF3</accession>
    <name>C4YPF3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar transporter chaperone 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_02352</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPF3"/>
    <dbReference type="PaxDb" id="5476-C4YPF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02352"/>
    <dbReference type="HOGENOM" id="CLU_141247_1_0_1"/>
    <dbReference type="OMA" id="MAIMIYA"/>
    <dbReference type="OrthoDB" id="2243669at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="17"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ44092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="115" mass="12936" checksum="3A8D7D01BCBE5234" modified="2010-10-05" version="1">MSSTNKRIALPARVEPKVFFANERTFLSWLNFTVILGSLGVGLLNFGDYVGRISAGLFTFIAMLTMVYALVTYHWRAKAIRLRGSGPYDDRFGPTMLCIFLLVAVVVNFILRIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPJ5</accession>
    <name>C4YPJ5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YPJ5"/>
    <dbReference type="HOGENOM" id="CLU_1570417_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="172" mass="19145" checksum="5EAFD68E2F99D705" modified="2009-07-28" version="1">MLMDSFRKSLTLVLVTILLSLKFVSTIQLVLFPLSKVLSNTMVHVHTSEDHQCVKFVQTFQLLQLLHQVPPLSQAPNQKLLVPHPLQVLLLLVLPVVNLSLLSFLLALLLLQLLQMDLTLPHSSSLSSKPLRLLLSLLVLTMLVIQQSLQSVLSSSHLLLSMSKSLSLLTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPQ9</accession>
    <name>C4YPQ9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LOG family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_02461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPQ9"/>
    <dbReference type="SMR" id="C4YPQ9"/>
    <dbReference type="PaxDb" id="5476-C4YPQ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02461"/>
    <dbReference type="HOGENOM" id="CLU_058336_1_1_1"/>
    <dbReference type="OMA" id="HQKPIGL"/>
    <dbReference type="OrthoDB" id="414463at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000018">
        <property type="entry name" value="Lysine decarboxylase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00730">
        <property type="entry name" value="Rossman fold protein, TIGR00730 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223:SF70">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102405">
        <property type="entry name" value="MCP/YpsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ44198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="24247" checksum="EFB2BEFA04E09801" modified="2010-10-05" version="1">MTQKSIKVCVFCGSSFGNKPVYAEEASKFGKALADKKWGLVYGGGSTGLMGAVASGCATNGGYVHGIIPEALISRERTVDEEAFNAKLKSSIDNHDGSTPIPDSKQYGKTTLVKDMHTRKRLMAQEADAFVALPGGIGSIDELAEITTWCQLNIHGKPIVVYNVDGYYDNFFKMIQGFVDCGFLSEKNGQIIKVANSVEEVLEIIENYEIPEGRFNLKWETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPT8</accession>
    <name>C4YPT8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPT8"/>
    <dbReference type="PaxDb" id="5476-C4YPT8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02491"/>
    <dbReference type="HOGENOM" id="CLU_486579_0_0_1"/>
    <dbReference type="OMA" id="LYSCERY"/>
    <dbReference type="OrthoDB" id="2534600at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="560" mass="64421" checksum="56A0B14BCCFE1BEE" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ63</accession>
    <name>C4YQ63_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA stability protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_02617</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the endosulfine family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ63"/>
    <dbReference type="PaxDb" id="5476-C4YQ63"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02617"/>
    <dbReference type="HOGENOM" id="CLU_101493_2_1_1"/>
    <dbReference type="OMA" id="IYRMYGK"/>
    <dbReference type="OrthoDB" id="5949865at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006760">
        <property type="entry name" value="Endosulphine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358">
        <property type="entry name" value="ENDOSULFINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358:SF6">
        <property type="entry name" value="ENDOSULFINE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04667">
        <property type="entry name" value="Endosulfine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ44352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="129" mass="14408" checksum="D230D111BC5A2F52" modified="2010-10-05" version="1">MSYSEEDPLSEPKNTQQLDLSKLSPQELRIYKMYGKLPTTQQILSSKFQDKKYFDSGDYAMQKQMGGGLKSGIPGGMSMKHPNAERMKEMSVRNSISATNAQVLLNGKSGLLNERTVGKDDNGEEQNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQF8</accession>
    <name>C4YQF8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_02715</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQF8"/>
    <dbReference type="PaxDb" id="5476-C4YQF8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02715"/>
    <dbReference type="HOGENOM" id="CLU_013513_4_1_1"/>
    <dbReference type="OMA" id="YADGYYK"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000020">
        <property type="entry name" value="Putative carnitine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.20">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042572">
        <property type="entry name" value="Carn_acyl_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF48">
        <property type="entry name" value="CARNITINE O-ACETYLTRANSFERASE YAT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="725"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="849"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="751"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="856"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ44447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="892" mass="100999" checksum="CB549D0923530E61" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQJ9</accession>
    <name>C4YQJ9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUN family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQJ9"/>
    <dbReference type="PaxDb" id="5476-C4YQJ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02758"/>
    <dbReference type="HOGENOM" id="CLU_026108_0_0_1"/>
    <dbReference type="OMA" id="NVAFCQT"/>
    <dbReference type="OrthoDB" id="5554151at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053088">
        <property type="entry name" value="Beta-glucosidase/SUN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005556">
        <property type="entry name" value="SUN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31654">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE ADG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31654:SF0">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE ADG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03856">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946819" evidence="2">
        <location>
            <begin position="18"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="279" mass="29805" checksum="F8E5792B1E7F60F8" modified="2009-07-28" version="1">MYFHSFIISSLIASAFANPIKKCGFPQDEDITNVGANGWAMSPDEPCTPGKFCPFACPPGKLMNQWDPEAVSYTFPKSMNGGLYCNEDGTTSKPFIGRSLCIDGVGTVSVVNKASDVVSFCQTVLPGNEAMLIPTEVGDGNEQVLAVPGPGYWAGTAAHYYVNPPGVSSKDACVWGTPEKAIGNWSPYVAGMNQDSNGNTFVTIGYNPKYIDDFSGNIPNFGIRIVCDNPDECNGLECEINPRQGFNKAMGPASGNSLGADYCIVTAKNHAHARIEVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQP2</accession>
    <name>C4YQP2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Suppressor of toxicity of sporidesmin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_02801</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YQP2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02801"/>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="OMA" id="EMNGIYM"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="term" value="F:ABC-type transporter activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016887">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylcholine floppase activity"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140341">
        <property type="term" value="F:phosphatidylethanolamine floppase activity"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC transporter CDR4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005285">
        <property type="entry name" value="Drug-R_PDR/CDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00956">
        <property type="entry name" value="3a01205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="588"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="624"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="653"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="760"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1193"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1226"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1265"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1316"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1347"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1465"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="148"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="857"/>
            <end position="1101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ44531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1499" mass="169014" checksum="0A71505A776A98E1" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQT2</accession>
    <name>C4YQT2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="PaxDb" id="5476-C4YQT2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04429"/>
    <dbReference type="HOGENOM" id="CLU_855286_0_0_1"/>
    <dbReference type="OMA" id="ELHWRDP"/>
    <dbReference type="OrthoDB" id="4093331at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="325" mass="36429" checksum="9B5BDFE1CDECE423" modified="2010-10-05" version="1">MSSHIFKDIQDKENELKTSGIRRKGIISNENAGPLLSKDSNSRQVQQPQQTQQQQQQSKFTNKRIPLGGKNHNSNKLLLNRSQSSLNTKPTTQGITNVKPPSLPKSNSSLGFSVVSDQPTEQQKQLPQPFVVHNEQVLPVKRKLLQDTKDELSQNSKRVKLEKKESNANTFTDSLTKPTQNVLAHVDDLQTTISSKTDQLNSSNLTHNDINRNNVDPVKRNSRLKAIDDLVESHWQDPIETIPETVGAENNNGEQLEELDIKFFSTPNESFDIGDLDENHLANNEQKLSLELDFEDESNVGEIPIIEGIDEEIGLTSDDLDNLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQW5</accession>
    <name>C4YQW5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arginine N-methyltransferase 2</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_04462</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQW5"/>
    <dbReference type="PaxDb" id="5476-C4YQW5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04462"/>
    <dbReference type="HOGENOM" id="CLU_033831_0_0_1"/>
    <dbReference type="OMA" id="YWVVDNY"/>
    <dbReference type="OrthoDB" id="19014at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019702">
        <property type="term" value="F:protein arginine N5-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000310">
        <property type="entry name" value="Arginine N-methyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017408">
        <property type="entry name" value="Arginine_N-MeTrfase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051038">
        <property type="entry name" value="RMT2/GAMT_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026480">
        <property type="entry name" value="RMT2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379:SF1">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038148">
        <property type="entry name" value="Arginine_N-mtfrase-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51559">
        <property type="entry name" value="SAM_RMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RMT2" evidence="8">
        <location>
            <begin position="202"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ46118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="451" mass="52274" checksum="8611BD57083CF9D1" modified="2009-07-28" version="1">MSELHDLCKFPTRPIDQSYIDKLTQYLKDGIPATYTIEEAYNYINNIEEEPTTTTTPLHLICSHAPFDITKEEQEIISTMVEKLFEYGAGWSFTDINNQTPGCILISRRKERENKEEDGKWMNDVYQQIIDAGVRAELLLRKVNEFEEIEFIEEDDEQEEKEEEDIPQLVKDEQEIKEEAKQEQTTTTDIKPVVIDDAPDAPSQNQQSYLNTKLEYINDALITKDDKDGVMMAWENDIMKLASDTITSSASSASDSESEQGVNILNIGFGMGIIDTMIQSKLKSHPNAKHYICEAHPDVLQKMKIDGWYEKPNVIILEGRWQDKLNDLLSSSSSSSEASVFFDGIYYDTFSEHYQDMLELFDIIVGLLKPHGIFSFFNGLGADRQIIYEVYKNLLIIDLENYGLNCQFKEFNVPNEKFWNKLQDKSIWDDVKRSYWSCPIYYHPIIKFIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR43</accession>
    <name>C4YR43_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_04542</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR43"/>
    <dbReference type="PaxDb" id="5476-C4YR43"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04542"/>
    <dbReference type="HOGENOM" id="CLU_073626_4_0_1"/>
    <dbReference type="OrthoDB" id="10254436at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ46195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="76" mass="8875" checksum="AB4C144AC39AC7DA" modified="2009-07-28" version="1">MHRTIIIRRDYLHYVPKYNRYEKRHKNVAAHVSPAFRVEEGDVVTVGQCRPISKTVRFNVLKVSAGASRSKKFSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR55</accession>
    <name>C4YR55_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">T-complex protein 1 subunit eta</fullName>
            <shortName evidence="10">TCP-1-eta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CCT-eta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_04554</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterooligomeric complex that forms two stacked rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR55"/>
    <dbReference type="SMR" id="C4YR55"/>
    <dbReference type="PaxDb" id="5476-C4YR55"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04554"/>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_1"/>
    <dbReference type="OMA" id="HRKGNTW"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03340">
        <property type="entry name" value="TCP1_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000074">
        <property type="entry name" value="T-complex protein 1 subunit delta, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012720">
        <property type="entry name" value="Chap_CCT_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02345">
        <property type="entry name" value="chap_CCT_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ46208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="549" mass="60422" checksum="5BE3B3EF2DA48A61" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRJ6</accession>
    <name>C4YRJ6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRJ6"/>
    <dbReference type="PaxDb" id="5476-C4YRJ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04696"/>
    <dbReference type="HOGENOM" id="CLU_025793_0_0_1"/>
    <dbReference type="OMA" id="RIAMIDW"/>
    <dbReference type="OrthoDB" id="410920at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001402">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001993">
        <property type="entry name" value="Serine/threonine-protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF68">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATG1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="209"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="639" mass="72450" checksum="0CE7C85295428A71" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRK8</accession>
    <name>C4YRK8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_04708</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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</entry>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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</entry>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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                <person name="Sakthikumar S."/>
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                <person name="Forche A."/>
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                <person name="Brunke S."/>
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                <person name="Hoyer L.L."/>
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                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EEQ46384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
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    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
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    </dbReference>
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        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF52">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="47"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="199"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="199"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ46384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="488" mass="52937" checksum="128A69B925FA372F" modified="2010-10-05" version="1">MRIPSARFVRTGLCSFKPRSFASGRLPYTYLATRAFHSSKIRAINFDPYKTLGVDKSADDRQIKKAYYDLVKKYHPDVNKEKDAEKRFHKIQESYELLRDKEKRAQYDQFGASAFDANGNANPFAGQGGNPFGGFGGGSAGGNPFSGMGFDFEDLFREAFAGGRGGAGGGRGGRSFVTEHVGDNIEVLKTIPFKDSIFGTSVTINYKAVDSCTTCSGSGLKAGAKKNTCPTCHGAGQTTHVMGGFHMSSTCPSCQGAGVTISKSDECGTCHGHGVQEIPKSKTVEIPAGVSDGTRIRIPGAGDAPMVTKDPYNQLVNGDLIIRINVQKDPVFSRNKNDLVINEEILMTTAALGGEIVVPTLDGQKIKLKVRPGVQNGRKLTIPEKGVPINRNLNNRGNLEVILNVKTVVPETPTQKALLEALADTFNDKNAKRTDADWSLDIEDDKNGKVNETYDESDLHPSKLKRIGKVLGKFFNFEQNDKGTKKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRR5</accession>
    <name>C4YRR5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Stretch-activated cation channel MID1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRR5"/>
    <dbReference type="PaxDb" id="5476-C4YRR5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04771"/>
    <dbReference type="HOGENOM" id="CLU_018731_1_0_1"/>
    <dbReference type="OMA" id="YEILPCI"/>
    <dbReference type="OrthoDB" id="5405745at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024338">
        <property type="entry name" value="MID1/Yam8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142:SF1">
        <property type="entry name" value="AEL197CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142">
        <property type="entry name" value="MID1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12929">
        <property type="entry name" value="Mid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944432" description="Stretch-activated cation channel MID1" evidence="1">
        <location>
            <begin position="19"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="62742" checksum="F8B6AA83431F7C77" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRS0</accession>
    <name>C4YRS0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_04777</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRS0"/>
    <dbReference type="PaxDb" id="5476-C4YRS0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04777"/>
    <dbReference type="HOGENOM" id="CLU_012852_0_0_1"/>
    <dbReference type="OMA" id="MDKEDWY"/>
    <dbReference type="OrthoDB" id="26740at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21675">
        <property type="entry name" value="SMP_TEX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF19">
        <property type="entry name" value="NUCLEUS-VACUOLE JUNCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15413">
        <property type="entry name" value="PH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="362"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="145"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="252"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="572"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="705"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="863"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="572"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="649"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="670"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="732"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="761"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ46423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="931" mass="104279" checksum="E649050C2D774107" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRV1</accession>
    <name>C4YRV1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyrimidine 5'-nucleotidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_04808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRV1"/>
    <dbReference type="PaxDb" id="5476-C4YRV1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04808"/>
    <dbReference type="HOGENOM" id="CLU_059493_0_1_1"/>
    <dbReference type="OMA" id="YPHHVNL"/>
    <dbReference type="OrthoDB" id="1065058at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SDT1p Pyrimidine nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010237">
        <property type="entry name" value="Pyr-5-nucltdase"/>
    </dbReference>
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        <property type="entry name" value="SSM1_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01993">
        <property type="entry name" value="Pyr-5-nucltdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438:SF1">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01132">
        <property type="entry name" value="C1.5.3:_5'-Nucleotidase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="33314" checksum="44BE2E257AC58266" modified="2009-07-28" version="1">MTVSNSQTVNYINPELTEVENAKPGRHVNLPFGYGPIPQQFKNKKIFFFDIDNCLYPRSTRIFEMMQVKIHDYFKKSLSLNDEDAHNLHMNYYKTYGLAIEGLVRNHQVDALDYNSKVDDALDLHSVLRYDSDLRKTLIAIKESSKFDYFWLVTNAYKNHALRVISFLGIGDLFDGLTYCDYSKDPIICKPMPEYFYNCFELTQLDYQNSAVLSEQYFIDDSELNVKEAKRLGVGHVIHYVELSSDVEKLKAKLDFEEFYGTGDNSDPNKIWILNKIQNLPNLIGCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRX9</accession>
    <name>C4YRX9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methionine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_04837</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="3"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRX9"/>
    <dbReference type="PaxDb" id="5476-C4YRX9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04837"/>
    <dbReference type="HOGENOM" id="CLU_009710_4_1_1"/>
    <dbReference type="OMA" id="HLNTTEY"/>
    <dbReference type="OrthoDB" id="5844513at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.20:FF:000001">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000040">
        <property type="entry name" value="Methionyl-tRNA synthetase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="entry name" value="Methionyl-tRNA synthetase, Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00098">
        <property type="entry name" value="Met_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018285">
        <property type="entry name" value="Met-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001100">
        <property type="entry name" value="PRK00133.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09635">
        <property type="entry name" value="MetRS-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="Methionyl-tRNA synthetase (MetRS), Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl-tRNA synthetase N-terminal heteromerisation" evidence="14">
        <location>
            <begin position="13"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="13">
        <location>
            <begin position="189"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="15">
        <location>
            <begin position="609"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEQ46482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="748" mass="84928" checksum="F3E5AAFCB0647C16" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRY6</accession>
    <name>C4YRY6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_04844</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cclA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRY6"/>
    <dbReference type="PaxDb" id="5476-C4YRY6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04844"/>
    <dbReference type="HOGENOM" id="CLU_014420_4_0_1"/>
    <dbReference type="OMA" id="GFRYTYA"/>
    <dbReference type="OrthoDB" id="10266026at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12872">
        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000043">
        <property type="entry name" value="Protein TRAUCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="110"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ46489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="466" mass="54049" checksum="C425C2E00B8FF679" modified="2009-07-28" version="1">MNKEISEEPSIEPQVQGNESIEETQSEHNYSTRSKERKREEELQKKSQLKQKQHNVVIHPRLKPVPFKNSDLNPASLPEPNAATTINEIEFFQTEDLPLNKRGFKYKHCRPNPEFPSNLYSTTDVPPYHVCASLFDRSSGILFSNDLKSITTAQGWRSSRTNVCIREGSYYFEFKILNSNEKSHVRIGVGRKEASLEAPVGFDGYSYGLRDVDGQFMTISRRQKLCIENGFKTGDVIGFLIQLPSLEEHRRALEEFVAEKSQLKPEQKLKKRKKKKIENDIKDNVKFIEHGNILRDQIPIKYKNALYYEQYEYTTTKTMEHLLNPVTVFGEKAIIEMDDKRKNIPVIPNSKIRLFKNGVEQEPITDLYSFLPTNIEDYEDINLGPNTKQQQNPNYRNTDDGTLGYYPMLSAFQFGVVNLNAGPNFEFPPQDPVKPLSDRYNEQVVEQYYWDLVDEVEAEYLDSFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS63</accession>
    <name>C4YS63_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucosamine-6-phosphate deaminase</fullName>
            <ecNumber evidence="3">3.5.99.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_04922</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="3"/>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS63"/>
    <dbReference type="PaxDb" id="5476-C4YS63"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04922"/>
    <dbReference type="HOGENOM" id="CLU_049611_0_1_1"/>
    <dbReference type="OMA" id="RGHVAFH"/>
    <dbReference type="OrthoDB" id="7663298at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006043">
        <property type="term" value="P:glucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280:SF5">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="5">
        <location>
            <begin position="8"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ46566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="182" mass="20261" checksum="CFC96529512BCDDA" modified="2009-07-28" version="1">MDEYLGLAPSDLQSYHYFMYDKFFNHIDIPRENIHILNGLAANIDEECANYEKKIKQYGRIDLFLGGLGPEGHLAFNEAGSSRNSKTRKVELVESTIKANCRFFGNDESKVPKYALSVGISTILDNSDEIAIIVLGKNKQFALDKTVNGKPNDPKYPSSYLQDHANVLIVCDNAAAGLKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS68</accession>
    <name>C4YS68_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Histone-binding protein RBBP4-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_04927</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS68"/>
    <dbReference type="SMR" id="C4YS68"/>
    <dbReference type="PaxDb" id="5476-C4YS68"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04927"/>
    <dbReference type="HOGENOM" id="CLU_020445_3_1_1"/>
    <dbReference type="OMA" id="PHEEGCL"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001977">
        <property type="entry name" value="Histone acetyltransferase type B subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="7">
        <location>
            <begin position="13"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="273"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="330"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ46571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="382" mass="42856" checksum="EC2E4DE6C2A4022E" modified="2009-07-28" version="1">MSEQPTEPLSIKEEYQLWRKNCRYMYEFVSETALMWPSLTIQWLPNYTTTNGLIDAKLLLGTHTSNQSANQLKVASTQLSADPNVKANSKIKTVQKLENNAEICRARYMPQDANIVATINGLGEVDLYNLDTETRYSHFAPHTKNGYGLSWNPKQKGLLVTGADDNFVCVTDTTTNKTTFKSDIQKDIVNDVKWHQFNGNLFASVSEDSHVYLFDARDNKVVSQYYAESSNGINSLAFSPFAENLVAIGNTSSNINLLDLRKLGENSGLLHTMMGHSEGITCMEFSPHHDGILATGSQDRRIIIWDLFKVGEEQQQEDAEDGCPELFMMHAGHTAGVSDLSWCPFKDWMIGSVADDNIVHLWEISKKLITNEEAEVDVSILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSB9</accession>
    <name>C4YSB9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">5'-AMP-activated protein kinase subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_04982</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Adenine nucleotides-binding subunit gamma of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (SNF1) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSB9"/>
    <dbReference type="PaxDb" id="5476-C4YSB9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04982"/>
    <dbReference type="HOGENOM" id="CLU_021740_1_0_1"/>
    <dbReference type="OMA" id="TASIHPF"/>
    <dbReference type="OrthoDB" id="286637at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000033">
        <property type="entry name" value="Nuclear protein SNF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 15" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CBS" evidence="16">
        <location>
            <begin position="131"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="16">
        <location>
            <begin position="208"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="16">
        <location>
            <begin position="275"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ46622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="335" mass="37558" checksum="58EB038AC6113F7E" modified="2009-07-28" version="1">MTDIAPPSAATPNDYILSLSPEQIEHDQKIGIKAIRLFLQSKTSYDVLPVSYRLIVLDTSLLVKKSLNILLQNNIVSAPLWNNQTSRFAGLLTSSDFINVIQYYLQFPEKFELVDQLTLGGLREIEKAIGVDQIETASIHPFKSLYEACVKMLESKARRIPLIDEDETKREIVVSVLTQYRILKFVALNCKETKMLLKPLKNLSGLGDVKKLSTCTMDTPVIEVIHLLTENSVSSIPIVDGQGKLINVYEAVDILALVKGGMYTDLDLSVGDALLRRSEEFEGVHTCTLNDRLSTIMDTIRKSRLHRLFVVDDEGKLVSVITLSDILNYILFGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSR3</accession>
    <name>C4YSR3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">tRNA pseudouridine synthase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">tRNA pseudouridylate synthase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">tRNA-uridine isomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAWG_05132</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr). Catalyzes pseudouridylation at position 44 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSR3"/>
    <dbReference type="PaxDb" id="5476-C4YSR3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05132"/>
    <dbReference type="HOGENOM" id="CLU_021971_0_1_1"/>
    <dbReference type="OMA" id="NKAFDCR"/>
    <dbReference type="OrthoDB" id="10256309at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="18">
        <location>
            <begin position="241"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="432"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="15">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00080858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEQ46766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="461" mass="53032" checksum="970CC9613576191C" modified="2009-07-28" version="1">MLGYCGTGYNGMQVQNDPNVKTIEKDIYDAMATAGAISAENAVDLKKSGFQRAARTDKGVHAAGNVISLKMIIEDPEIINKINDLLPKQIRIWGIQRTTKGFDCRKCCSSRIYEYLLPTFSLLPPKPKSVLSELVKEKKLENPDLFEDDQEGIEWWENVKSKILASGITQEQIDSITSSYDEQQQQQQQQQQQQQQADEEERDVSELSFTKLIKQIKTIENQSRRSYRISSSRLQHFREVMKQYEGTHNFHNFTVGKPFKDTSANRFMIKTIVSDPFVIEGTEWISIKIHGQSFMLHQIRKMIAMAALVVRLSLPCGIINNFFQSTKINIPKAPALGLLLENPVFDGYNIKLTKSDYEPIDFTKFDKEMNEFKMKYIYDKIYAEESKENIFYGFFGYIDAYRGNKNEDGEPIQNGASIFDFLFNYTERVENTKNKDAKNTSKTEESKPEESKPEESKSEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSX6</accession>
    <name>C4YSX6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_05671</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
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        <text evidence="3">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
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        <property type="protein sequence ID" value="EEQ47112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="SMR" id="C4YSX6"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05671"/>
    <dbReference type="HOGENOM" id="CLU_169286_3_1_1"/>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
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        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ47112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="99" mass="11905" checksum="7DC21CA8EB9A31C9" modified="2009-07-28" version="1">MHPQLDKNRFNTCDKLMDALEECHRQEFLKQCLGMCNFEKEQLIQCLHYQRVEDSKLRILETREKRKNWELKKKQAEEEAYGKNGYLKKVLEAEAASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSY9</accession>
    <name>C4YSY9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_05685</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">May be involved in rRNA-processing and ribosome biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the 90S pre-ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat NOL10/ENP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSY9"/>
    <dbReference type="PaxDb" id="5476-C4YSY9"/>
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    <dbReference type="HOGENOM" id="CLU_009923_0_0_1"/>
    <dbReference type="OMA" id="GYFMDVR"/>
    <dbReference type="OrthoDB" id="273340at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000537">
        <property type="entry name" value="Ribosome biogenesis protein ENP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056551">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056550">
        <property type="entry name" value="NOL10_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23098">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23097">
        <property type="entry name" value="NOL10_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="14">
        <location>
            <begin position="21"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like second" evidence="13">
        <location>
            <begin position="386"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="12">
        <location>
            <begin position="508"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="522"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="542"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="565"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="578"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="596"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="637"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="647"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="662"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="715"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00064135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ47125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="750" mass="84967" checksum="D5ED2E0203EBB59C" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT38</accession>
    <name>C4YT38_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT38"/>
    <dbReference type="PaxDb" id="5476-C4YT38"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05736"/>
    <dbReference type="HOGENOM" id="CLU_1948538_0_0_1"/>
    <dbReference type="OMA" id="QPICMPA"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946882" evidence="2">
        <location>
            <begin position="19"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ47174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="129" mass="12613" checksum="3FE8FB2E27123F59" modified="2010-10-05" version="1">MKFTTIAAAAFIACSVEATFLPLLKLGGGWKGGNNEPPCDTPAPPPPPPPPAQTTPCDTPPAPPAPTTPCDTPPAETTPCDTPPAQPTPCETEGGSGGNGGSGGYGGGGIIGSIIGKKVKFIEGLLGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT39</accession>
    <name>C4YT39_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT39"/>
    <dbReference type="ESTHER" id="canal-q5a0c9">
        <property type="family name" value="CGI-58_ABHD5_ABHD4"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YT39"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05738"/>
    <dbReference type="HOGENOM" id="CLU_017361_3_1_1"/>
    <dbReference type="OMA" id="ADQHLVM"/>
    <dbReference type="OrthoDB" id="7457040at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF23">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE ICT1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="112"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ47175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="443" mass="51095" checksum="93E18267ADB2BEA6" modified="2009-07-28" version="1">MSTETVTSTTTTSPSTSKRQKVSEFNDGRKTPSYPWLQSATDWFKQSLKPSYADEQVERRLLSYLPFFPESDGSRRASVINTDIGNGNYIHELFIENLEKDTSKDASSTKEIVLVHGYAASLGLFIDNFDSLSRIPGIKIHAIDLLGFGLSSRPKFPQFPSKTKQDIYKVEDWFIDSLETWRKKRNIGKFILMGHSFGGYLSCAYALKYNKKIIERGISSNLIEKLILISPVGVERSQYSLLKKETNLTPQVSPEQELLVNQEDIVHGNEIEQDPRTRTRRLLEYMWVHNYSPFTIIRNAGPFKSKLISRWTTHRFSHVYYQDEQQFKNIHDYIYRIFNGKGSGEYALTRVLDVGAVAKLPLLDRCPEKFVKMKLPTLWLYGDKDWMNDEAGLEMTNEINDLSNQENSENLPVSYHIECSNTIFTSDKSTGNLLKLYFKFLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTP4</accession>
    <name>C4YTP4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_05539</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTP4"/>
    <dbReference type="PaxDb" id="5476-C4YTP4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05539"/>
    <dbReference type="HOGENOM" id="CLU_015166_6_4_1"/>
    <dbReference type="OMA" id="TTVWKHE"/>
    <dbReference type="OrthoDB" id="428293at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015215">
        <property type="term" value="F:nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00784">
        <property type="entry name" value="MTUNCOUPLING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="16"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="125"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="229"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ46985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="316" mass="35587" checksum="069E1241FC2453C3" modified="2009-07-28" version="1">MELNTTDKQVHTRRFSSREIEVISGLLAGFSTTIVTHPLDVIKIRLQLSRDTPKTTHPLESIISVIKKINQDAKVAYKLNHKPKAFNYLIQYYRGITPNLIGNISAWGIYFALYAEFKSKVKTNNTTMNYFASSVLAGLSTSIITNPLWVLKTRILGSSRNESNAYRSVTDGIRQMLAKEGITSFWKGTIPSLFSVVQASLQITIYDHIKVYLSSPHHRSESIGATSHLSTWQYLYSSASSKIISMLILYPTQVVRSRLQYSQDSSSSIVSIVKELYYKEGGLKGFYKGIGANILRVLPATCVTFVAYENVKRYLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTU2</accession>
    <name>C4YTU2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="2 7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_05587</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 7"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTU2"/>
    <dbReference type="SMR" id="C4YTU2"/>
    <dbReference type="PaxDb" id="5476-C4YTU2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05587"/>
    <dbReference type="HOGENOM" id="CLU_012062_4_2_1"/>
    <dbReference type="OMA" id="FKSIVPR"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="5"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ47033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="162" mass="17575" checksum="3467726615CDB50D" modified="2009-07-28" version="1">MSTVYFDVSADGQKLGKITFKLYDDVVPKTAENFRALCTGEKGFGYKGSIFHRVIPQFMLQGGDFTNFNGTGGKSIYGTKFADENFVKRHDRPGLLSMANAGPNTNGSQFFITTVPCPWLDGKHVVFGEVTDGLDIVKKIESFGSGSGATSKKIVIEESGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCY6</accession>
    <name>C4YCY6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">H/ACA ribonucleoprotein complex subunit CBF5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">H/ACA ribonucleoprotein complex subunit cbf5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_00372</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>uridine in 5S rRNA = pseudouridine in 5S rRNA</text>
            <dbReference type="Rhea" id="RHEA:47036"/>
            <dbReference type="Rhea" id="RHEA-COMP:11730"/>
            <dbReference type="Rhea" id="RHEA-COMP:11731"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCY6"/>
    <dbReference type="SMR" id="C4YCY6"/>
    <dbReference type="PaxDb" id="5476-C4YCY6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00372"/>
    <dbReference type="HOGENOM" id="CLU_032087_3_2_1"/>
    <dbReference type="OMA" id="KYGRTNE"/>
    <dbReference type="OrthoDB" id="10250002at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="10">
        <location>
            <begin position="19"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="268"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="358"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="435"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="479" mass="54322" checksum="3BAF5104E12C9EB6" modified="2009-07-28" version="1">MSSKEDYIIKPESVSPSNDTSQWPLLLKNYDKLLVRSGHYTPIPAGSAPLNRDIKSYVSSGVINLDKPSNPSSHEVVAWIKRILRVEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCIVRLHEQLKDDKELNRALENLTGALFQRPPLISAVKRQLRVRTVYDSKLIEFDNKRGLGVFWASCEAGTYMRTLCVHLGMLLGVGGHMQELRRVRSGAMSESDNLVTLHDVLDAQYVYDNTRDESYLRKIIQPLESLLVGYKRVVVKDSAVNSVCYGAKLMIPGLLRYEEGIELYDEVVLMTTKGEAIAIGIAQMSTVDLQSCDHGIVAKVKRCIMERDTYPRRWGLGPIAQKKKQMKADGKLDKYGRVNENTPENWKKDYKDLDEQPAPPIPESKLVAPEPQLPKKKSLIEEVEVDIDVEDKSEKKEKKDKKEKKEKKDKKEKKEKKDKKEKKRKAEDDSSKSEKKKKSKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD02</accession>
    <name>C4YD02_CANAW</name>
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        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_00389</name>
    </gene>
    <organism evidence="3 4">
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        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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            <end position="125"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ42188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="837" mass="94161" checksum="20BF156B3009CB4F" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD43</accession>
    <name>C4YD43_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="9 10">
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        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
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                <person name="Cuomo C.A."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00431"/>
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    <dbReference type="OMA" id="KMFKNAN"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-EC"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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    </feature>
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        <location>
            <position position="827"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ42229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="963" mass="107712" checksum="B7D47AA5C2D38740" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDK0</accession>
    <name>C4YDK0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">General negative regulator of transcription subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_00595</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDK0"/>
    <dbReference type="PaxDb" id="5476-C4YDK0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00595"/>
    <dbReference type="HOGENOM" id="CLU_013819_3_0_1"/>
    <dbReference type="OMA" id="YKPQTPY"/>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="14">
        <location>
            <begin position="497"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="233"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="319"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="365"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="3"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ42386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="662" mass="74785" checksum="BD91DCB40F80E8C1" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDS8</accession>
    <name>C4YDS8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Survival protein SurE-like phosphatase/nucleotidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_00676</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDS8"/>
    <dbReference type="PaxDb" id="5476-C4YDS8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00676"/>
    <dbReference type="HOGENOM" id="CLU_045192_0_0_1"/>
    <dbReference type="OMA" id="DSHIWYY"/>
    <dbReference type="OrthoDB" id="4018688at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1210.10:FF:000005">
        <property type="entry name" value="Acid phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="5'-NUCLEOTIDASE SURE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457:SF0">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946559" description="Survival protein SurE-like phosphatase/nucleotidase domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ42464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="323" mass="34971" checksum="6536BB4E5CAD769A" modified="2009-07-28" version="1">MQFLTSALVLLLSVGALAKNILLTNDDGWQATNIRATYYKLKEAGHNVFLVAPVSQRSGFSGKFDIPTSPTLQTNGEFNYPPAGAPSWGHEVDDNHIWYFNGTPASSAVFGINYVIPKYGDNVTIDLVVSGPNEGTNMSPGLFTISGTVGATYTSIYRGIPGVAFSGSNSNNSFFKDSLDLKDNKEPSTIYANKVVEFVNQIFKAQGNNPRALGLGVGLNVNFPKVGYENETCTNPKWVFTRSTGQYAAGANLVYNETSNSFTWGQKSWDGLTVCNNGDCSLPSENFIVEHTNCQSSVSVFSVDYDANLGLTSQVKQILNPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YE26</accession>
    <name>C4YE26_CANAW</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CAWG_00776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00776"/>
    <dbReference type="HOGENOM" id="CLU_332598_0_0_1"/>
    <dbReference type="OMA" id="DHTHDIT"/>
    <dbReference type="OrthoDB" id="4025857at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="791"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
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            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
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        <location>
            <begin position="283"/>
            <end position="322"/>
        </location>
    </feature>
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            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
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            <end position="409"/>
        </location>
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            <begin position="439"/>
            <end position="451"/>
        </location>
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        <location>
            <begin position="567"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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        </location>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="791"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="877" mass="97607" checksum="101E49F4ADBF5BCA" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YE70</accession>
    <name>C4YE70_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pirin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_00823</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pirin family.</text>
    </comment>
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        <property type="protein sequence ID" value="EEQ42606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YE70"/>
    <dbReference type="SMR" id="C4YE70"/>
    <dbReference type="PaxDb" id="5476-C4YE70"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00823"/>
    <dbReference type="HOGENOM" id="CLU_045717_0_1_1"/>
    <dbReference type="OMA" id="TPWHPHR"/>
    <dbReference type="OrthoDB" id="198735at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="4">
        <location>
            <begin position="21"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="5">
        <location>
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            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006232-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ42606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="38457" checksum="B8C794B244FEE820" modified="2009-07-28" version="1">MSTRSIAKIVTANEQAEGAGARVRRSIGIMNQRNFDPFLMFDHFSSAGTNGFPEHPHRGQETITLVLNGAMAHEDFTGSKGILYAGDLQFMTAGKGVVHSEMPVANADGSPTVGLQLWVDLPNNMKGVKPRYRDLREWEIPEVVTDDGKVTIKVISGRSHGVESVKELAYTPINYYYYKVKAGGEFKQELQPGFNYFLYVLNGRNLVLNEDTKVDRYQNVFFGDKGDFITGKNAATKDNNETEVQFILVGGKKLEQEVVQYGPFVASSRDNIQKAFQDYQYGRNGFENIKTWQTLISGGVTKEMIEGPLNGNLEKRAAKKKAFLEKQQKKAAPVAAQPELVKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEH4</accession>
    <name>C4YEH4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type ATPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_00931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEH4"/>
    <dbReference type="PaxDb" id="5476-C4YEH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00931"/>
    <dbReference type="HOGENOM" id="CLU_518732_0_0_1"/>
    <dbReference type="OMA" id="INSHAYG"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF5">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="2">
        <location>
            <begin position="161"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ42710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="525" mass="58221" checksum="C6E1479D8FCE64E6" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEK2</accession>
    <name>C4YEK2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PQ-loop repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_00959</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEK2"/>
    <dbReference type="PaxDb" id="5476-C4YEK2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00959"/>
    <dbReference type="HOGENOM" id="CLU_049047_1_0_1"/>
    <dbReference type="OMA" id="QMSLDIY"/>
    <dbReference type="OrthoDB" id="292213at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052241">
        <property type="entry name" value="SLC66/Scramblase_ANY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856:SF9">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ42738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="36800" checksum="AF1BD972076475F0" modified="2009-07-28" version="1">MGFSLDICCTMFMASILRIYYYFCSPYEPTLLRQSIIMILIQTLLLKVSLYYRPANYDPELLTSMPLLENELNMRVPRRLSSATLEHQSYWSGDWISSLGTITFDIIKYVSGYFIAYFNQGLRFFDVYYRRPLSFWQWKLEANYWWFVIGFSTVFGITTLIFHENVMYSNIIGVLGLFIESLLPLPQILLLNRLQSVKNFKVILLLSWLGGDCTKISYLLFGTDNISIIFIVAGLFQMSLDIYIAFQYLQFKYFTTTNKNLNDGASLHRRNQSIDDVVNDLVSVSSEIELDVLEKGQKDISNNQTSSWSRSRSSTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEM3</accession>
    <name>C4YEM3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein ERB1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic ribosome biogenesis protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ERB1</name>
        <name evidence="10" type="ORF">CAWG_00980</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat BOP1/ERB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEM3"/>
    <dbReference type="PaxDb" id="5476-C4YEM3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00980"/>
    <dbReference type="HOGENOM" id="CLU_011390_0_1_1"/>
    <dbReference type="OMA" id="MRPAKGE"/>
    <dbReference type="OrthoDB" id="5571054at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03027">
        <property type="entry name" value="BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="9">
        <location>
            <begin position="179"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="448"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="816"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="562"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ42759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="842" mass="96521" checksum="3ADC3803C26FB602" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YER7</accession>
    <name>C4YER7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_01025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YER7"/>
    <dbReference type="SMR" id="C4YER7"/>
    <dbReference type="PaxDb" id="5476-C4YER7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01025"/>
    <dbReference type="HOGENOM" id="CLU_084533_0_0_1"/>
    <dbReference type="OMA" id="HEGENDQ"/>
    <dbReference type="OrthoDB" id="636685at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22929">
        <property type="entry name" value="HFD_POLE4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF151">
        <property type="entry name" value="DNA POLYMERASE EPSILON NONCATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="63"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="196"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ42803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="237" mass="26036" checksum="9BDF2E5D3771A259" modified="2010-10-05" version="1">MSQEEQSGHLSPQEPREEALTVTSQSEPSATTPKSDDQNAADPQPEQQPQLNQEQDEFQNNLTLPISKIKKIFKMDPEYTGASASAVYTAGLATELFVQYFAEQASLLAKMEKRKKIQYKDFSNAVASHDALNFLSDTIPRTQPIGELVQQKKINVKQTAPKTTKDNGDVNANPQVGDIVKKDLLVKGQQTLNFPIANSASSKTPEGPVKKSVISNLVTTEDDRSTKDGDDDVVMKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEW1</accession>
    <name>C4YEW1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Biogenesis of lysosome-related organelles complex 1 subunit CNL1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">CNO-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_01070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex that is involved in endosomal cargo sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLOC1S4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEW1"/>
    <dbReference type="PaxDb" id="5476-C4YEW1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01070"/>
    <dbReference type="HOGENOM" id="CLU_141728_0_0_1"/>
    <dbReference type="OMA" id="HFDMLDQ"/>
    <dbReference type="OrthoDB" id="5424991at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24144">
        <property type="entry name" value="BLOC1_CNL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034455">
        <property type="entry name" value="CNL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39145">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT CNL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39145:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT CNL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ42847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="158" mass="18587" checksum="2ADB18A485A2C9AD" modified="2009-07-28" version="1">MSFDEGRNNSLDQVVSQDNTKDKDNHNDLLPQPSGQVSTSSPQKDNTPPSPTPSNDDPDPLELKKLSLNYDYLMYKIKDYINTLTEQTYQSILSKQYQIDQEYLHDQLNLFDNYETIDEMLKTISQLEMEFLKLDQLEVFIEDFKQRLNVLEHEFDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEW8</accession>
    <name>C4YEW8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_01077</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12 13">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ORC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEW8"/>
    <dbReference type="PaxDb" id="5476-C4YEW8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01077"/>
    <dbReference type="HOGENOM" id="CLU_012774_1_1_1"/>
    <dbReference type="OMA" id="FFNWPTY"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04720">
        <property type="entry name" value="BAH_Orc1p_Yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000274">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000199">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041083">
        <property type="entry name" value="AAA_lid_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048867">
        <property type="entry name" value="WHD_ORC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17872">
        <property type="entry name" value="AAA_lid_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21312">
        <property type="entry name" value="WHD_ORC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82061">
        <property type="entry name" value="BAH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="15">
        <location>
            <begin position="60"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="218"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="271"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEQ42854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="805" mass="91241" checksum="18A313EE48A0FD35" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEZ3</accession>
    <name>C4YEZ3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Alpha-aminoadipate reductase</fullName>
            <ecNumber evidence="6">1.2.1.31</ecNumber>
            <ecNumber evidence="5">1.2.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAWG_01102</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = L-2-aminoadipate + ATP + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.2.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(S)-2-amino-6-oxohexanoate + NADP(+) + H2O = L-2-aminoadipate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.31" evidence="6"/>
    <dbReference type="EC" id="1.2.1.95" evidence="5"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YEZ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01102"/>
    <dbReference type="HOGENOM" id="CLU_000022_19_0_1"/>
    <dbReference type="OMA" id="ENDKFTM"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004043">
        <property type="term" value="F:L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd17647">
        <property type="entry name" value="A_NRPS_alphaAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000046">
        <property type="entry name" value="L-2-aminoadipate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000787">
        <property type="entry name" value="L-2-aminoadipate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000035">
        <property type="entry name" value="L-2-aminoadipate reductase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000049">
        <property type="entry name" value="L-aminoadipate-semialdehyde dehydrogenase large subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000020">
        <property type="entry name" value="Peptide synthetase mbtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014397">
        <property type="entry name" value="Lys2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03443">
        <property type="entry name" value="alpha_am_amid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF1">
        <property type="entry name" value="L-2-AMINOADIPATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001617">
        <property type="entry name" value="Alpha-AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="18">
        <location>
            <begin position="848"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEQ42879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1404" mass="155387" checksum="EED20B23F4C39B15" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFP7</accession>
    <name>C4YFP7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxycytidylate deaminase</fullName>
            <ecNumber evidence="7">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_00023</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="7"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFP7"/>
    <dbReference type="PaxDb" id="5476-C4YFP7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00023"/>
    <dbReference type="HOGENOM" id="CLU_047993_0_1_1"/>
    <dbReference type="OMA" id="YFMRLAD"/>
    <dbReference type="OrthoDB" id="6710946at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000035">
        <property type="entry name" value="dCMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004543">
        <property type="entry name" value="Deoxycytidine monophosphate deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="10">
        <location>
            <begin position="187"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ41836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="337" mass="38093" checksum="621D98BE3AC366E3" modified="2009-07-28" version="1">MLIGISGTLSSGKTEVARYLTFQGFKLISFKQEGHESDATTPEEDEVSHQITDLTVDADYKMEVFKHFDDLSALDNYVTVNWQDNFVISHIQDMNMLKALQKRPFFLHISIDAPVYLRYQRSKSKNNFTLEQFVDKNDQLLFNVANPLIEINNQAQVKIINTSTSIKDLFIKLSELNLLNSSRLRPTWDSYFMRLADLAALRSNCMKRRVGCVIVRENRVVATGYNGTPRHLTNCNEGGCSRCNKGQGSGASLATCLCLHAEENALLEAGRDRIRGESVLYCNTCPCLTCSIKIVQSGIREVVYAQSYSMDLQSHKVMSEANIILRQFHPPKDGIFI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-31" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFU9</accession>
    <name>LCL3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>Probable endonuclease LCL3</fullName>
            <ecNumber>3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">LCL3</name>
        <name type="ORF">CAWG_00075</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LCL3 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFU9"/>
    <dbReference type="SMR" id="C4YFU9"/>
    <dbReference type="PaxDb" id="5476-C4YFU9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00075"/>
    <dbReference type="HOGENOM" id="CLU_046484_0_1_1"/>
    <dbReference type="OMA" id="IYHTPGG"/>
    <dbReference type="OrthoDB" id="430293at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000035">
        <property type="entry name" value="Probable endonuclease LCL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0106">Calcium</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000408651" description="Probable endonuclease LCL3">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="3">
        <location>
            <begin position="59"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="235" mass="27374" checksum="9900B28BDD053ED7" modified="2010-10-05" version="1">MPPIPAEPTENISIFHPKVLLLSAGVTTSLFFGYKFYKRYIKRIRTYLDLTPSIIENNTKLYGYVTRVGDGDNFRFYHTPGGWFFGWGWLRKIPTTRKDLKDETLMIRLCGVDAPEGAHFGKPAQPYSKEALYWLREYVDGKYVTITPYSIDQYKRVVARAQIWKWTGRKDVSAEMLKVGYAIVYEGKAEAEFGDNEDWYRKLESRAKLLRKGVWSLGKNLTTPGEFKRIHYRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFV7</accession>
    <name>C4YFV7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_00083</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFV7"/>
    <dbReference type="PaxDb" id="5476-C4YFV7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00083"/>
    <dbReference type="HOGENOM" id="CLU_064620_2_1_1"/>
    <dbReference type="OMA" id="VRKKMWW"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15874">
        <property type="entry name" value="R-SNARE_Snc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005409">
        <property type="entry name" value="Synaptobrevin_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ41896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="110" mass="12371" checksum="8A1360CA46245048" modified="2009-07-28" version="1">MSSSAPYDPYIPNQTTGDQSNSRTAAIQAVDDTVGIMRDNINKVAERGERLDSIENKTDNLAISAQGFRRGANRVRKDMWWKDFKMRMCLIFGIIIVIIVIVVPIAVHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFW0</accession>
    <name>C4YFW0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="4">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_01348</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="4"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFW0"/>
    <dbReference type="PaxDb" id="5476-C4YFW0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01348"/>
    <dbReference type="HOGENOM" id="CLU_004588_3_0_1"/>
    <dbReference type="OMA" id="EYCNQME"/>
    <dbReference type="OrthoDB" id="418791at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000045">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054692">
        <property type="entry name" value="LeuA-like_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002991">
        <property type="entry name" value="PRK03739.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911:SF2">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22615">
        <property type="entry name" value="IPMS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="10">
        <location>
            <begin position="31"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ43111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="558" mass="61582" checksum="7D36FD69481BFCC8" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFW1</accession>
    <name>C4YFW1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_01349</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFW1"/>
    <dbReference type="PaxDb" id="5476-C4YFW1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01349"/>
    <dbReference type="HOGENOM" id="CLU_026791_0_0_1"/>
    <dbReference type="OMA" id="EAMNGEY"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12447">
        <property type="entry name" value="RRM1_gar2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000550">
        <property type="entry name" value="Nuclear localization sequence binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000621">
        <property type="entry name" value="Nuclear localization sequence-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050886">
        <property type="entry name" value="RNA-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024">
        <property type="entry name" value="GEO13361P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024:SF11">
        <property type="entry name" value="NUCLEAR LOCALIZATION SEQUENCE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="168"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="270"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="230"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="342"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ43112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="399" mass="43410" checksum="59A9FC5277F6932A" modified="2009-07-28" version="1">MAKASKVDKKLSKKKEEKPAKKVEEESSSEESSSDDSSSEESSSDDDSSDDSSSSSSDEGSDSDSSDEEEVEKKESSSDESDDEDKKEESSSGSDEEEKKEEKSSSSDSEDSSSSDSSSSESDSDSDSDSDSDSEEEPSKKRKAEESKEEESAPVKKSKPAASTEEPATLFVGRLSWNIDDAWLKREFEHIGGVIGARVIMERATGKSRGYGYVDFESKSAAEKALEEMQGKEIDGRPINLDMSTGKPHASKSNNDRAKQYGDSQSPPSDTLFIGNLSFNANRDNLFNVFGEYGNVISCRVPTHPDTQQPKGFGYVQFSSVDEAKAALEAMNGEYIEGRPCRLDFSTPRDNTNNNNNNRRGGFGGGFGGRERSATPRSGNSTPRPNKSTEFKGTKKTFD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-10-19" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFX2</accession>
    <accession>P56093</accession>
    <accession>Q5AB65</accession>
    <name>TUP1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>Transcriptional repressor TUP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">TUP1</name>
        <name type="synonym">CHP1</name>
        <name type="ORF">CAWG_01360</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="Science" volume="277" first="105" last="109">
            <title>Control of filament formation in Candida albicans by the transcriptional repressor TUP1.</title>
            <authorList>
                <person name="Braun B.R."/>
                <person name="Johnson A.D."/>
            </authorList>
            <dbReference type="PubMed" id="9204892"/>
            <dbReference type="DOI" id="10.1126/science.277.5322.105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Represses transcription by RNA polymerase II. Represses genes responsible for initiating filamentous growth and this repression is lifted under inducing environmental conditions.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAB63195" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="AF005741">
        <property type="protein sequence ID" value="AAB63195.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFX2"/>
    <dbReference type="SMR" id="C4YFX2"/>
    <dbReference type="PaxDb" id="5476-C4YFX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01360"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_23_1"/>
    <dbReference type="OMA" id="HYLVPYN"/>
    <dbReference type="OrthoDB" id="17410at2759"/>
    <dbReference type="PHI-base" id="PHI:211"/>
    <dbReference type="PHI-base" id="PHI:6806"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000111">
        <property type="entry name" value="Transcriptional repressor rco-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000043">
        <property type="entry name" value="Transcriptional repressor TUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013890">
        <property type="entry name" value="Tscrpt_rep_Tup1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08581">
        <property type="entry name" value="Tup_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000413064" description="Transcriptional repressor TUP1">
        <location>
            <begin position="1"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="197"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="252"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3">
        <location>
            <begin position="294"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4">
        <location>
            <begin position="335"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5">
        <location>
            <begin position="384"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 6">
        <location>
            <begin position="431"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 7">
        <location>
            <begin position="473"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAB63195." evidence="2" ref="1">
        <original>Q</original>
        <variation>QQ</variation>
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAB63195." evidence="2" ref="1">
        <original>V</original>
        <variation>A</variation>
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="511" mass="57503" checksum="7A7377D80381A354" modified="2009-07-28" version="1">MYPQRTQHQQRLTELLDAIKTEFDYASNEASSFKKVQEDYDSKYQQQAAEMQQIRQTVYDLELAHRKIKEAYEEEILRLKNELDTRDRQMKNGFQQQQQQQQQQQQQQQQQQQIVAPPAVPPAPPTPVTSLSVIDKSQYIVNPTQRANHVKEIPPFLQDLDIAKANPEFKKQHLEYYVLYNPAFSKDLDIDMVHSLDHSSVVCCVRFSRDGKFIATGCNKTTQVFNVTTGELVAKLIDESSNENKDDNTTASGDLYIRSVCFSPDGKLLATGAEDKLIRIWDLSTKRIIKILRGHEQDIYSLDFFPDGDRLVSGSGDRSVRIWDLRTSQCSLTLSIEDGVTTVAVSPDGKLIAAGSLDRTVRVWDSTTGFLVERLDSGNENGNGHEDSVYSVAFSNNGEQIASGSLDRTVKLWHLEGKSDKKSTCEVTYIGHKDFVLSVCCTPDNEYILSGSKDRGVIFWDQASGNPLLMLQGHRNSVISVAVSLNSKGTEGIFATGSGDCKARIWKWTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFX7</accession>
    <name>C4YFX7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper-fist domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_00088</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFX7"/>
    <dbReference type="PaxDb" id="5476-C4YFX7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00088"/>
    <dbReference type="HOGENOM" id="CLU_017782_0_0_1"/>
    <dbReference type="OMA" id="HHFGRTG"/>
    <dbReference type="OrthoDB" id="5600085at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="118"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="213"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="290"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ41901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="593" mass="64402" checksum="52E86C9EA3A8F996" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFZ4</accession>
    <name>C4YFZ4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_00107</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFZ4"/>
    <dbReference type="PaxDb" id="5476-C4YFZ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00107"/>
    <dbReference type="HOGENOM" id="CLU_422719_0_0_1"/>
    <dbReference type="OMA" id="SGHREIN"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
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        </location>
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        </location>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ41918.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
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    </evidence>
    <sequence length="646" mass="71234" checksum="AB3D9323918C4247" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG53</accession>
    <name>C4YG53_CANAW</name>
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        <recommendedName>
            <fullName evidence="2">Transcription elongation factor Eaf N-terminal domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">CAWG_00171</name>
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    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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                <person name="Kellis M."/>
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            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
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        </source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG87</accession>
    <name>C4YG87_CANAW</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
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                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
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                <person name="Silverstein K.A."/>
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                <person name="Staggs R."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        </location>
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        </location>
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        </location>
    </feature>
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            <end position="383"/>
        </location>
    </feature>
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            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="409" mass="46674" checksum="40548B4AFFFB934B" modified="2009-07-28" version="1">MKSSINLHSHTIDLSTLEELRDPNLISRYPPLFQRKQNLIALDNSTKSIKRSKTVSTPITTNNRATNLTPIVSAPTSNYYQVQSTHTLNRRPCVESKESISNKRHRFVKFWKNISAKSNKMSRHECLIQSISKPVDYYCQQQQQHQPALSPDTCGSIFLNSLYPSKSRNTINIKPDDRMSYEDGRGYDMSNSTSNDNDGVDNLNYHDSEFDLSRRNTYISQMKFQPMSPPQELSAVNSIVIPPVGGSNQIDNPEEFASPIIHPNIHLEQQRQQHEEELSKNKNNNFINKYKHDPKFNSGHTRIPHHSTISFAKYDLMNLDTSAMSPIETPGDDDDEEEELITLNRGDFILPNSSFFIPTTTTSIVNSDTDSHESYYSFSKSPETTTTNNNNNNNYNSMSTIVRGEHVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGF5</accession>
    <name>C4YGF5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_03131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Lin M.F."/>
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                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
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                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
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                <person name="Fitzpatrick D.A."/>
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                <person name="Lorenz M.C."/>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 16">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="14">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Mitochondrion inner membrane</location>
            <topology evidence="16">Peripheral membrane protein</topology>
            <orientation evidence="16">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="16"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGJ0"/>
    <dbReference type="SMR" id="C4YGJ0"/>
    <dbReference type="PaxDb" id="5476-C4YGJ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03167"/>
    <dbReference type="HOGENOM" id="CLU_014312_6_1_1"/>
    <dbReference type="OMA" id="NRCAETI"/>
    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000026">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 14 16" id="KW-0274">FAD</keyword>
    <keyword evidence="6 14 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 16" id="KW-0813">Transport</keyword>
    <keyword evidence="5 16" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="18">
        <location>
            <begin position="56"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="19">
        <location>
            <begin position="506"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="580"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="61"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="450"/>
            <end position="451"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="15">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000171-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEQ44872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="641" mass="70176" checksum="894AE33A9B3062F5" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGJ1</accession>
    <name>C4YGJ1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_03169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGJ1"/>
    <dbReference type="SMR" id="C4YGJ1"/>
    <dbReference type="PaxDb" id="5476-C4YGJ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03169"/>
    <dbReference type="HOGENOM" id="CLU_055868_0_2_1"/>
    <dbReference type="OMA" id="FPTWREY"/>
    <dbReference type="OrthoDB" id="110024at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="term" value="C:nucleus"/>
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        <property type="entry name" value="DnaJ"/>
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    <dbReference type="FunFam" id="1.10.287.110:FF:000207">
        <property type="entry name" value="Uncharacterized J domain-containing protein C1071.09c"/>
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        <property type="entry name" value="DnaJ domain"/>
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        <property type="entry name" value="DnaJ_domain"/>
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        <property type="entry name" value="DnaJ_domain_CS"/>
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        <property type="entry name" value="HTH_DNAJC9"/>
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        <property type="entry name" value="J_dom_sf"/>
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        <property type="entry name" value="J_domain-containing_protein"/>
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        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
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        <property type="entry name" value="JDOMAIN"/>
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        <property type="entry name" value="DnaJ"/>
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        <property type="entry name" value="Chaperone J-domain"/>
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    </dbReference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="9"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="274" mass="32754" checksum="CB270CE09C972920" modified="2010-10-05" version="1">MGIPFPDIDPYETLGVSKDCSPLEIKKTYKKLCLKYHPDKLRQNNNDNDKDKQQEMFTKIQFAFSILNDPVKRKRYDNTGSLADYDLEDEGFDWKDYFESINEKITVEMVEEDRLKYQGSEEEKYDILNNFIYYDGDFLKLFELIPHLEFTESEEQRVYKIIDKELNNLQVNDSVRKSWEKYTKSRKTKVKQMLKKLAKEAKQAEELQQLLQNKPKKGQDLTSLIKSRQANRLDDLINNLESKYKDKKGKKRSPKDIDEDEFERIQNEIMKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGQ3</accession>
    <name>C4YGQ3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_03234</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="HOGENOM" id="CLU_021528_0_0_1"/>
    <dbReference type="OMA" id="FSPMIQP"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
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        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
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        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="326"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="237"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="376"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="533"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="276"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="446"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="533"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="556"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ44935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="582" mass="63077" checksum="98084C5F6BB4B36C" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGS7</accession>
    <name>C4YGS7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase II subunit RPB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_03259</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGS7"/>
    <dbReference type="SMR" id="C4YGS7"/>
    <dbReference type="PaxDb" id="5476-C4YGS7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03259"/>
    <dbReference type="HOGENOM" id="CLU_038421_1_1_1"/>
    <dbReference type="OMA" id="FYFEVES"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07031">
        <property type="entry name" value="RNAP_II_RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="9">
        <location>
            <begin position="20"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ44959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="318" mass="35046" checksum="DD3C4CF7D4514BB6" modified="2010-10-05" version="1">MEIDSHEGPSVTIREAEKDHVNFILKNVDLAVANSMRRTIIAEVPTLAIDLVEIDVNTSVLADEFLSHRLGLIPLVSEGIDNLTYSRDCTCDNYCSKCSVTLQLIANCATESTMNVYASDLQKMSHNGSKLGDPVIRDPQARGPLICKLRKHQELSLTCIAKKGIAKEHAKWSPTAAIGFEYDPWNKLKHTDYWYEVDAEAEWPKSKNCDWEEAPDPEAPFDYKAKPSTYYFDVETVGNLPPNEVIIKSIETLQTKLAAISIELNKEDVEVNEAAAGGFTSYGRTEYGRTEYGGADGGQTPGGRTPYGDSGFGGAQWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHW7</accession>
    <name>C4YHW7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">triacylglycerol lipase</fullName>
            <ecNumber evidence="1">3.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_03670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.3" evidence="1"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHW7"/>
    <dbReference type="PaxDb" id="5476-C4YHW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03670"/>
    <dbReference type="HOGENOM" id="CLU_032957_3_0_1"/>
    <dbReference type="OMA" id="YEHRAYF"/>
    <dbReference type="OrthoDB" id="406844at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF3">
        <property type="entry name" value="LIPASE LIH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012022673" description="triacylglycerol lipase" evidence="3">
        <location>
            <begin position="16"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="4">
        <location>
            <begin position="103"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ45349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="333" mass="38231" checksum="27132DB95F2E9BBB" modified="2009-07-28" version="1">MLILIIIVLYCLSFAQEYKTDNEPAQDYKKIVQFSNLAAVAYCVGRGLSKGRLGDKGSGCHLSACKNDILKDVEIVKIFDFSTLNEVGTGYYALDKKRKTIILVFRGSVSRRDWATDIDFIPTKYRPIVQDDNFECEVFIQQECINCKVHRGFYNFLKDNSGAIISLGIKLKKIYPDYQFLIIGHSLGAAFTTLSGIEFQLLGYDPLVVTYGGPKVGNQEFADFTDRLFDTEEVANCITMKNDFSRGFIRVVHKHDIIPFLPPMFTHAGYEYFIDKKQLPHEECDIDRRGMEYSGLLWKRSSGIRPSTFWPDSLGKYEHTHYFRRITSCRDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHY0</accession>
    <name>C4YHY0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_03684</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YHY0"/>
    <dbReference type="HOGENOM" id="CLU_234583_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1872"/>
            <end position="1962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1925"/>
            <end position="1937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1951"/>
            <end position="1962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ45362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1962" mass="224237" checksum="20A01EAD7A97AEDA" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHY7</accession>
    <name>C4YHY7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_03691</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHY7"/>
    <dbReference type="PaxDb" id="5476-C4YHY7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03691"/>
    <dbReference type="HOGENOM" id="CLU_000384_9_4_1"/>
    <dbReference type="OMA" id="MITEIVN"/>
    <dbReference type="OrthoDB" id="4022548at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="7">
        <location>
            <begin position="156"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ45369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="258" mass="29553" checksum="4262C553B7BFFECA" modified="2009-07-28" version="1">MVGHLNIDDLEIAEEDLQGGEINLSILLGNEKLLNMIKDSYQADEYLLKVIKYLKEEEEVPSEMKSAIKKYKMHDDLLLYKSFATFKPVVSSEAAKEIIRTFHRQGHVGITKIYWAIQPYVFVPKLLTMITEIVNACDTCQRTKSISRYMGGLMMPSEVPRDCFSHIHVDFITGLPVTVEGYDAIMVVVDALTKYTICCPCKKTYSAMDVAKMLMNEVFSVFGLPHKIISDKDIRFMNSVFDYIYEYYQIQMATTSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI14</accession>
    <name>C4YI14_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_03721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI14"/>
    <dbReference type="PaxDb" id="5476-C4YI14"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03721"/>
    <dbReference type="HOGENOM" id="CLU_051515_0_0_1"/>
    <dbReference type="OMA" id="VESWHSI"/>
    <dbReference type="OrthoDB" id="2894435at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="233"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ45396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="292" mass="34464" checksum="E70DED7E8FB9AE7D" modified="2009-07-28" version="1">MNLNYFLKQQVNLLYNPVDEVPVDKHLDDIAAFLESNNFELDVKIEDANNEIAKIEAPKPFPKTLEDINEVKKIAAEGFYLIMFSKSEEEANQRINDYIIAFMEYPYYIIYIQYWLNRKQCWLKGYSPNQQGMRLTNNFVESWHSILKGKFLSRSRMKRADNLIYILYYDVLDYYKTKDKMSSAQYDKPNITKASKGNKEIVNALTNEEIEKRVEIKESEIFVQSFAQEDVFYEIKKNGNTYSCNCKNYHPIKICTHVYIASRYISVHPIKEISKKRKAVITETVNKRQKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI33</accession>
    <name>C4YI33_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_03741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI33"/>
    <dbReference type="PaxDb" id="5476-C4YI33"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03741"/>
    <dbReference type="HOGENOM" id="CLU_010039_0_0_1"/>
    <dbReference type="OMA" id="NRITWRY"/>
    <dbReference type="OrthoDB" id="331602at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd09264">
        <property type="entry name" value="AP_Syp1_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018808">
        <property type="entry name" value="Muniscin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049609">
        <property type="entry name" value="Syp1-like_MHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10291">
        <property type="entry name" value="muHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD" evidence="2">
        <location>
            <begin position="586"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ45415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="811" mass="90135" checksum="2CF0A039F5DBC7ED" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIH1</accession>
    <name>C4YIH1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein kinase BUR1</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Serine/threonine-protein kinase bur1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAWG_04246</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIH1"/>
    <dbReference type="SMR" id="C4YIH1"/>
    <dbReference type="PaxDb" id="5476-C4YIH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04246"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_21_1"/>
    <dbReference type="OMA" id="NQISNCQ"/>
    <dbReference type="OrthoDB" id="28397at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000415">
        <property type="entry name" value="CMGC/CDK/CRK7 protein kinase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF233">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="44"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="367"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="367"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="429"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="494"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="587"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="600"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="633"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="662"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="693"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEQ45906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="746" mass="83396" checksum="2E5B86F5EA624D85" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIK6</accession>
    <name>C4YIK6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_04282</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIK6"/>
    <dbReference type="PaxDb" id="5476-C4YIK6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04282"/>
    <dbReference type="HOGENOM" id="CLU_000288_118_2_1"/>
    <dbReference type="OMA" id="PHEEFRN"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14019">
        <property type="entry name" value="STKc_Cdc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000637">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF23">
        <property type="entry name" value="CDC7 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="173"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="348"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="632"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="355"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="645"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ45941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="655" mass="74850" checksum="57562C55383444F9" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIL4</accession>
    <name>C4YIL4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIL4"/>
    <dbReference type="PaxDb" id="5476-C4YIL4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04290"/>
    <dbReference type="HOGENOM" id="CLU_637768_0_0_1"/>
    <dbReference type="OMA" id="MTQYLSK"/>
    <dbReference type="OrthoDB" id="3986620at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="430" mass="49286" checksum="6FD725B339AFC97C" modified="2009-07-28" version="1">MTQYLSKDSLFLKLPTDLSKDEISVQDLYQDITSLTTTPTPKVTFDSIINKTYYLLKSTNDISNALKLWQIRLTCHLFNNQLSYAKKESINLNNTLYLQENHNITLPPPPPAASSSSSLSLSNGSTPNATTTTTNNNPIYPLPKNNQLIIDFKLLILLLRLKNFPNMNLINELYKLIYQLRLKRNDNINNDQISLLLVKNLQNLSYDNIVILTLTKNYLTLINFLSNLIQELKELKDSEDKKQNMADSFDCDYYSNINLIYLIINLIVHHKNHNQNHIDVVINDTNFNHIWDTQINETTKNSLIYTLQHIPPSIASKPDNNSQESSIQFKCDTIKDLGQLVQEGKITGRIICSMLGIWDLSNTYGFTLSNNSNSDGNSALQFTKINSQEDHQQQQHLDINTLSKDEIITKCCDLLNDQWCNYINKVYGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIR6</accession>
    <name>C4YIR6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyl-CoA thioesterase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ46001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIR6"/>
    <dbReference type="PaxDb" id="5476-C4YIR6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04343"/>
    <dbReference type="HOGENOM" id="CLU_032690_2_1_1"/>
    <dbReference type="OMA" id="FHYNAMS"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="2">
        <location>
            <begin position="229"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="384" mass="43442" checksum="AED70B13E2881461" modified="2009-07-28" version="1">MLELTAGPNPVPDFEEALRVIKLDETHYVGAHPLKLPVTGGRGVYGGHLIAQSLLVAIESTRDSTTNQVFIPDSYHSYFINAGNAKTPMNYTVTKLYDDSISSKRFIVVQQNGKNRLTCLVNLRKPGTKTLHQEGSGPNISIPVPPIQLKYPNPDELHQVQHTDFVRNAFGKEFIDYRECPEEKDQYAAERWLTVFTGLRNHAEPGASLEAVTEELPDASGKIHKVEKVILRPKDSQSVRDPIYNYVGLADLSDSAFLTTMARILHIPWAPSLEIDETYDESRDATYIMRTTLNAAHIFHYNAMSLDHHIYFHNQDYTPDDDSNFDICKDWLAFTYQMKRLSNNRTLVRGFLFNEKHKCIATVVQEGLTIVYNGVGNTADKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ03</accession>
    <name>C4YJ03_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA repair protein RAD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAWG_03815</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EEQ45487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YJ03"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03815"/>
    <dbReference type="HOGENOM" id="CLU_000315_2_5_1"/>
    <dbReference type="OMA" id="KVEPWSN"/>
    <dbReference type="OrthoDB" id="2801544at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
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        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
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        <property type="entry name" value="SNF2_N"/>
    </dbReference>
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        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="450"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="816"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="913"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="11"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEQ45487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1084" mass="125197" checksum="F8054EBC98770A69" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ25</accession>
    <name>C4YJ25_CANAW</name>
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        <recommendedName>
            <fullName evidence="6">Chromatin structure-remodeling complex protein RSC58</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_03837</name>
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    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ25"/>
    <dbReference type="PaxDb" id="5476-C4YJ25"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03837"/>
    <dbReference type="HOGENOM" id="CLU_043834_0_0_1"/>
    <dbReference type="OMA" id="PNWYSLP"/>
    <dbReference type="OrthoDB" id="5354116at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050720">
        <property type="entry name" value="Engrailed_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341">
        <property type="entry name" value="HOMEOBOX PROTEIN ENGRAILED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341:SF6">
        <property type="entry name" value="HOMEOBOX PROTEIN INVECTED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="321"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="491"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="333"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="353"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ45509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="58421" checksum="138E8F3E7FEFA316" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ29</accession>
    <name>C4YJ29_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein-lysine N-methyltransferase EFM3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_03841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ29"/>
    <dbReference type="PaxDb" id="5476-C4YJ29"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03841"/>
    <dbReference type="HOGENOM" id="CLU_038942_1_1_1"/>
    <dbReference type="OMA" id="MYVTDGD"/>
    <dbReference type="OrthoDB" id="194386at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF130">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ45513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="37272" checksum="1138C2104FD3774E" modified="2009-07-28" version="1">MNRRFFSLIEQRVPAKYISFTVDDLKYDSQLEFVNRIQTVLPLNPYYVKTVLKEYIKHIESSNEDTSDELYELYCDPDVLNSKELNPEQTDVIKYFISGFNQQYSGDGKDTITIKETPKLISGSNTTGLRTWEAALYLSNFLNGKDSPPYNLKNKTVMEIGCGTGLVSLALAKNYHRKIDNIKRLIMTDGSTNVFDNLQETLRLNELNDSSIIQCQQLIWGENTTIEDDVDFLVAADITYDTRILDPLCQTIQDLFANNNLQFAVIAATVRNMDTIKEWESKLDVWFARKWLVRATESDPHSIQSNCWFNVNTPQIRIYEIHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ43</accession>
    <name>C4YJ43_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_03855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ43"/>
    <dbReference type="PaxDb" id="5476-C4YJ43"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03855"/>
    <dbReference type="HOGENOM" id="CLU_2037752_0_0_1"/>
    <dbReference type="OrthoDB" id="10331128at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ45527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="121" mass="14121" checksum="F4FAFD760798142B" modified="2010-10-05" version="1">MYYRGFYRGAPFCRFGFGSLFLLGGAFILGSIVSGNRPPWSRRFHHWGCQCPDCVRRTFEFRNHHHMGCQCPECSLRLKHGNYHETNDYPQEIDNRFDRYGNDHNQPRNQSSSNSGNNGPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ88</accession>
    <name>C4YJ88_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription factor IIIC 90kDa subunit N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ88"/>
    <dbReference type="PaxDb" id="5476-C4YJ88"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03901"/>
    <dbReference type="HOGENOM" id="CLU_369188_0_0_1"/>
    <dbReference type="OMA" id="WSDNLQL"/>
    <dbReference type="OrthoDB" id="6021743at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024761">
        <property type="entry name" value="TFIIIC_delta_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12657">
        <property type="entry name" value="TFIIIC_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor IIIC 90kDa subunit N-terminal" evidence="1">
        <location>
            <begin position="24"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="705" mass="80681" checksum="3EC4E8188F83D461" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJA5</accession>
    <name>C4YJA5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_03918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJA5"/>
    <dbReference type="PaxDb" id="5476-C4YJA5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03918"/>
    <dbReference type="HOGENOM" id="CLU_769457_0_0_1"/>
    <dbReference type="OMA" id="WMAIDEN"/>
    <dbReference type="OrthoDB" id="4013612at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ45589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="42807" checksum="7EB72C585FFB36A3" modified="2009-07-28" version="1">MVLNIKKCLESNSLACMEQSILMLPHELIARILSMNYSMYGSLKHIYYFVVTCKEMYYRHVFLLYTLEPVMVSLCKCNKAISLVAMGFLKQSKLCYNIRCLDWFLTPKFTTAKHYQKTILDSINQFSNLYKVCLTANSLDMLMQVNRLPKCVSVLKINLITHVNPTRHTMRLDKVPLFRLKVLIFETSAPLSLTEYYYPFFRSILISKSPLYSWMAIDENVPEAHVKSPINQVCNILATLIYHSRSTLEYLNIHKLHPVFVFRAMDVVFHHGGINLSLFGSSEIDIQNLSEFPSLKYLKIDNSYSLTDNLIQKLMGRNKQSLIVLDYMYLQEIMHATLFEGNHVHKEFYDRNTGFATKVLTELNTLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJR1</accession>
    <name>C4YJR1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sfm1p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_04080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJR1"/>
    <dbReference type="PaxDb" id="5476-C4YJR1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04080"/>
    <dbReference type="HOGENOM" id="CLU_080487_0_0_1"/>
    <dbReference type="OMA" id="LEYIHIC"/>
    <dbReference type="OrthoDB" id="373498at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18090">
        <property type="entry name" value="Arginine_MT_Sfm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="SFM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517:SF1">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="SFM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ45745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23649" checksum="5000FF56C2BDF4AC" modified="2009-07-28" version="1">MKYIIEHMEEGFSEWVILEYTQIIKDIGKDNLILTSLPPSTTEKDIPKRLLELGLQWTTKECVDIDGGIDKSKVCLLDPAAETDLTPQDKSKFDYFVFGGILGSHPRIDRTGLLREKYGFSGRRLGSLQMTTDTAIRTTQRIIENGVAFEDIKFLDYPEIKYNKYESTEMPFRYVTDNEGNPILPEEMLELIKNDAEQSIDDLLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK53</accession>
    <name>C4YK53_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Meiosis-specific serine/threonine-protein kinase MEK1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_05849</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK53"/>
    <dbReference type="PaxDb" id="5476-C4YK53"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05849"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="OMA" id="EDQYTIT"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22670">
        <property type="entry name" value="FHA_MEK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001666">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="49"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="148"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ47282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="50674" checksum="C0511EB3DC3F7C2A" modified="2009-07-28" version="1">MDVIGILQIILIDNTQILLSKLNKDQEKYARPSISGNVIVVPLLRQQVLTIGRSPKCKVQLINPTVSMEHCIIWAIQFDSDSNLITYIFDKSRNGIKHNEADMSFGLTGILENRDTIEIKTAAHITYKCLQTKVSSQTELDQLMEDWEISNKMIGCGSFGAVYVAKKPNNPKLFAVKITQNNQSGYFSNNSKPTQESYLLSKINHPNIIRIYDTITRNSKIFLFQDLICGGDLFSYLVKDDYLKAIPERETIFIVFQIMKALHFLHKKLKIVHRDLKLDNILLELPIPGSKIYLCDFGIAKHLGYNNRTNTCVGTLEYSAPEVFKADKSGNKAVQSYDFKCDTWSLGVITHILLSGVSPFYSESKDKILKASRLGQLNFAKPQFSKISLSSKSYIKKLLRVEVTSRMDINDCFDHNWIKLQRKKLEKKYYSVVGDRQSSLPPPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK94</accession>
    <name>C4YK94_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_05891</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK94"/>
    <dbReference type="PaxDb" id="5476-C4YK94"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05891"/>
    <dbReference type="HOGENOM" id="CLU_028458_2_1_1"/>
    <dbReference type="OMA" id="EYKGQSP"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF100">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G01490)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="79"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ47323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="292" mass="32256" checksum="38761D58D41E89F4" modified="2009-07-28" version="1">MSWKRLIRFVARDGKIYRGEPIFTDTNYDVGKKYLAGDQLKAKVIKGTNIFENTIVTDEILEVVKLLGPLTPEDVPIVKCIGLNYTKHIEESGIPAPPYPPLFYKPRTCVADFNEPIPISKIAQVDQCDYEGELCVVIGKSGKNIAKENALEYVGGYVVGNDVSARTWQLDPKYAGGAPQWCFSKSFDKYAPLGPQLVSPVVLTDPSALHLQTRVNGELRQDSPTSDLLFNVSEIIAFLSQSTTLERGTVIMTGTPSGVAMGMKDQKYLQDGDEVEVSITQIGTLVNKMRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKC6</accession>
    <name>C4YKC6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKC6"/>
    <dbReference type="PaxDb" id="5476-C4YKC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05925"/>
    <dbReference type="HOGENOM" id="CLU_061432_0_0_1"/>
    <dbReference type="OMA" id="NKGIWHY"/>
    <dbReference type="OrthoDB" id="94039at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="65"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="397" mass="46658" checksum="74A7DA9AD25F58EC" modified="2009-07-28" version="1">MHLKPSDSPYYERTLKVKDAANPRAPGSVVLSKPSHLREDYQLKIAYRKYVTTRQIPFNSPRINFLFLHGNGMNKGIWHYQIDKLFTMYEVSFPDMHIDTVIAADHVNMGDSANVNRGKLGHVSDWNDSAKDYIMITKIHERDAFLHPNAFNVVVAHSMGGFIAMQMTAIEPNLFQSSILINPVCVTFPELRHHNLKVYQDWYHRDFVKFYFDNIPEGENWYHKIYEHYTNRSFYRKFHPVVLRNMLEDEIPEMYDRSKYYRTVELKHDGLEDYINYYNSEESITATKSSYEQIRVPTKILCGENDALATFIDSQKDQELSFAEIQVLEGKYHNMHAESPDLIMSLVNDFVVTCYKEHPKITDFEYYKKYGSDYKSILRKKKLHDLLGDNTNIPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKH4</accession>
    <name>C4YKH4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_05978</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKH4"/>
    <dbReference type="PaxDb" id="5476-C4YKH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05978"/>
    <dbReference type="HOGENOM" id="CLU_000445_81_3_1"/>
    <dbReference type="OMA" id="MCHGSPY"/>
    <dbReference type="OrthoDB" id="2447880at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="entry name" value="DNA Methylphosphotriester Repair Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004026">
        <property type="entry name" value="Ada_DNA_repair_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02805">
        <property type="entry name" value="Ada_Zn_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="Ada DNA repair protein, N-terminal domain (N-Ada 10)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="6">
        <location>
            <begin position="92"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ47403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="178" mass="20580" checksum="678560BC993F2CEC" modified="2009-07-28" version="1">MRFTDDETKYQAILNRDPQAEGEFVYGAISTRIVCRPTCNCRVAMRKNVVFFDTITEAVEHGYRTCKRCKPEKSSGWNKSREFINKSCSMISRRAINGEKLNIDTIIAAVGVSKWHFYRMFKNYTGLTPRSFYIQCQLLQENPLDTTPLPEIETKRNLKRVKEILNLYTTPNSNSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKM9</accession>
    <name>C4YKM9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_06035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKM9"/>
    <dbReference type="SMR" id="C4YKM9"/>
    <dbReference type="PaxDb" id="5476-C4YKM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06035"/>
    <dbReference type="HOGENOM" id="CLU_024937_0_0_1"/>
    <dbReference type="OMA" id="RQVNCVE"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF3">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005667905" description="Thioredoxin domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="682"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="22"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="713"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ47458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="737" mass="84998" checksum="3377BF5F67135079" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL25</accession>
    <name>C4YL25_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_01539</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL25"/>
    <dbReference type="PaxDb" id="5476-C4YL25"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01539"/>
    <dbReference type="HOGENOM" id="CLU_333507_0_0_1"/>
    <dbReference type="OMA" id="LWRIKKN"/>
    <dbReference type="OrthoDB" id="5860513at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF33">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="7">
        <location>
            <begin position="152"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="432"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="785" mass="92167" checksum="2B80D4F017AD35B9" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL27</accession>
    <name>C4YL27_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_01541</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL27"/>
    <dbReference type="SMR" id="C4YL27"/>
    <dbReference type="PaxDb" id="5476-C4YL27"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01541"/>
    <dbReference type="HOGENOM" id="CLU_073641_0_0_1"/>
    <dbReference type="OMA" id="QHMMAFI"/>
    <dbReference type="OrthoDB" id="10263003at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="entry name" value="ATP synthase, E subunit, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45715">
        <property type="entry name" value="ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160527">
        <property type="entry name" value="V-type ATPase subunit E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ43308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25387" checksum="C57109F304490D4D" modified="2009-07-28" version="1">MALSDEQVKSELSKMQAFIEKEAKEKAKEIKLKADEEYEIEKASIVRSETAAIDSTYEQKLKKASLAQQITKSTIGNKTRLRILSTKDEVLHEIFDEAEAELKKITKDKKQYKPVLVGLIEEGVLALMEPKVSIKVREQDVDVAKEAITEAAKNFEEKAKFKVEISIDDKNFLAKDIAGGIVVVNGSGKIEVDNTLEERLKILSEEALPAIRLELFGPSTTRKFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL49</accession>
    <name>C4YL49_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_01564</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL49"/>
    <dbReference type="PaxDb" id="5476-C4YL49"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01564"/>
    <dbReference type="HOGENOM" id="CLU_020880_3_1_1"/>
    <dbReference type="OMA" id="TGEMDAK"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000021">
        <property type="entry name" value="Acid phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF18">
        <property type="entry name" value="ACID PHOSPHATASE PHO11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="62"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="404"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ43330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="462" mass="51338" checksum="4D13239E60F60B75" modified="2009-07-28" version="1">MVSVSKLLNNGLLLTGQSVFQDVATPQQASVQQYNIVNFLGGSAPYIQRNGYGISTDIPAGCEIAQIQLYSRHGERYPSKSNGKSLEAIYAKFENYKGTFKGDLAFLNDYTYFVTDKNNYEKETSPKNSEGTYAGTANALRHGAAFRAKYGSLYKENSTLPVFSSNSGRCYQTSRYFARGFLGDDFKEGKTVKFNIISEDADVGANSLTPRSACSKNKESSSSTAKKYNTTYLNAIAERLVKPNPGLNLTTSDVSNLFGWCAYEINVRGSSPFCDLFTNEEFIKYSYGNDLSNYYSNGAGNNYTRIIGSVILNSSLELLKDTKNSNQVWLSFAHDTDLEIFHSALGLLEPAEDLPTSYIPFPNPYVHSSIVPQSARIYTEKLQCGNDAYVRYIINDAVVPIPKCATGPGFSCKFDDFENFVKERIGDVDFVKQCGVNSTYPSELTFYWDYKNVTYNAPLGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL85</accession>
    <name>C4YL85_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH-ubiquinone oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_01602</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the complex I NDUFA8 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL85"/>
    <dbReference type="PaxDb" id="5476-C4YL85"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01602"/>
    <dbReference type="HOGENOM" id="CLU_081931_1_0_1"/>
    <dbReference type="OMA" id="FRTHWQC"/>
    <dbReference type="OrthoDB" id="276296at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016680">
        <property type="entry name" value="NDUFA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017016">
        <property type="entry name" value="NDUA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ43366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="172" mass="19778" checksum="383B8ECAFB472524" modified="2009-07-28" version="1">MLGLGGYFYGGKQWENKEETPMPKDVPDVDEVGATSAPLLSASYYIGDKCKPFNEDFLLCKEEHNGGTLECMKEGRRVTRCAISVLKDINKYCFDEFKLHYECLEQNNQYFSRCRSSEGVLSKCVFDNMKLVKKIPGVEQQIQDKKNPIYPSDPNDVKKGRRIFEIKRSYSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL91</accession>
    <name>C4YL91_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_01608</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCB family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL91"/>
    <dbReference type="PaxDb" id="5476-C4YL91"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01608"/>
    <dbReference type="HOGENOM" id="CLU_067577_2_0_1"/>
    <dbReference type="OMA" id="DQYEQRT"/>
    <dbReference type="OrthoDB" id="5295208at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="4">
        <location>
            <begin position="209"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ43372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="284" mass="32917" checksum="AD9D7713E77292BA" modified="2009-07-28" version="1">MSDLNIFITSNLTSSERRISPQWNLKYLKQKLESITGISPQNQILHYYPNNHSNEYKLIPPINGSTTTDDDDDDEQILLSSLNLQSYSRIHVIDSDPNSDVNKLQQQHQQHQEEEEEEEKSEIEEGDVAGFTEFQLSEEDYKTRQNSVLNWKKINKLGRFDPQFQSLQEKLHHETEMKLKTMSIGSRCRLINIENNERRGIIRFIGKIMPLDNGENDWVGIEFDEPVGKNNGSIDGVKIFECKPNHGSFVRPRLVEVGDFPELDPFADDDDDDDDEDMDDDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLG0</accession>
    <name>C4YLG0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type ATPase assembly factor PKR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_01678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLG0"/>
    <dbReference type="PaxDb" id="5476-C4YLG0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01678"/>
    <dbReference type="HOGENOM" id="CLU_068499_1_0_1"/>
    <dbReference type="OMA" id="VKLWEDI"/>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013945">
        <property type="entry name" value="Pkr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28251">
        <property type="entry name" value="V-TYPE ATPASE ASSEMBLY FACTOR PKR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28251:SF1">
        <property type="entry name" value="V-TYPE ATPASE ASSEMBLY FACTOR PKR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08636">
        <property type="entry name" value="Pkr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ43441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13226" checksum="CEB483EFD1EFAB82" modified="2009-07-28" version="1">MSFFVELWESVFTPGTTPALITATHASFILLIISLLVLIFLTKSIHFINLLVIAVLLYASVFWFINELQQVKLQSNNELSQKELEKESESEKLSANATESSQTTATPEDIKPRKRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLP3</accession>
    <name>C4YLP3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_01762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLP3"/>
    <dbReference type="PaxDb" id="5476-C4YLP3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01762"/>
    <dbReference type="HOGENOM" id="CLU_1686329_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="156" mass="17787" checksum="D1AEC832ABBD64B0" modified="2009-07-28" version="1">MDNLYKNKENFEILKSYDSMDSYTINTIMSSEATASNWLDCSKLDFEEHSKLELQGGFPDVNIYSSPGPTPGLLEQESDPESLEPSYFLMKARTKYLQNQDNMIVGCQKTFSNEFFNHRKQAANLAYKIFEDGVEDDESDLDIVSKYVTPSDVMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLS7</accession>
    <name>C4YLS7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_01796</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Vacuole membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLS7"/>
    <dbReference type="PaxDb" id="5476-C4YLS7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01796"/>
    <dbReference type="HOGENOM" id="CLU_034559_0_0_1"/>
    <dbReference type="OMA" id="FWVEQVL"/>
    <dbReference type="OrthoDB" id="42657at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF2">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ43558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="500" mass="56525" checksum="A9B585F2B1443C27" modified="2009-07-28" version="1">MKVNHNHISNTSVNNSEDVLEAQDEISNDNNKNQESIWNKKSIFHTWLLLCYSTGPVASMSRTYVPASIQSIAKNVGKTKMNQPCGTQGNDCYVKFGFMTVHHTSYVLYLRAVSTAIEGVVAIFLMGIADYSNYRKLFLIFSILVYGFLALPFIGLTNNDYQTLVLASILYSLLIIDDSIYQILEGSYIPLFMRADKENPMQRGSVVAVLGLFLGNLGGITALVIGIIISYLSATPESKGYHNFLLAITIAGCLTIGLSLFSALYIPNVQGKQRIDNFLVLPFKRFFNLLKDIQKYPMAFLYCISWVIWNVSFNNFMSMFLLLFRSTLGLGNSDAEYTVYTFMSYICSSWGSLLWMFLYQKWNSNIKYWGYSFLSVSLLANFWGCLGIHKLTPLGYQNRWEFWVFEVFYSATSSAMRSLNRCVYSSLLPEGNEAQYFGLEVTLGIASGWIGGLVNAVIQDRTNDDRFPFLPNMILVVVSLIVYYYVDLQKGKNDVNNGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLX5</accession>
    <name>C4YLX5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL53</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">54S ribosomal protein L44, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_01847</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL53 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLX5"/>
    <dbReference type="SMR" id="C4YLX5"/>
    <dbReference type="PaxDb" id="5476-C4YLX5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01847"/>
    <dbReference type="HOGENOM" id="CLU_131037_1_1_1"/>
    <dbReference type="OMA" id="TIDYKIL"/>
    <dbReference type="OrthoDB" id="4136894at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000260">
        <property type="entry name" value="Mitochondrial ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019716">
        <property type="entry name" value="Ribosomal_mL53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042776">
        <property type="entry name" value="Ribosomal_mL53_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28236">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L44, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28236:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10780">
        <property type="entry name" value="MRP_L53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="91" mass="10280" checksum="C31A76ABBF83F94E" modified="2009-07-28" version="1">MITKYFANVSVKFNPFSNAGKSARLFLSRVPTGTKIDCKVLTKPSDIQEIKVTFKDKHVMTANPATMRLADLSEYFDIHSRKLAIKDSIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLX6</accession>
    <name>C4YLX6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Decapping nuclease</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_01848</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLX6"/>
    <dbReference type="PaxDb" id="5476-C4YLX6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01848"/>
    <dbReference type="HOGENOM" id="CLU_674429_0_0_1"/>
    <dbReference type="OMA" id="FNVIYWK"/>
    <dbReference type="OrthoDB" id="5853397at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="8">
        <location>
            <begin position="41"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ43607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="398" mass="46592" checksum="39AD0E15210D9758" modified="2009-07-28" version="1">MERIPLSVFEKFNNQELLSDVPEDRFISKSLQSPEIFSTPCEECTYFTKSNNNNILKFDDTTGLNTVLVSYTQQSKKRKQKKTNASSKGRPKIIGSDLTQGFSDFKPESLKDIYSLNDIFKSIQYLIQNKNFTPQDFKIVTARRHLQKLMTIPIHKQEVQFNVIYWKGMIFFAYDWKSESTTKVEDPYNKLIQYTGFKFEEVVSDGTRDSNFYTVVQHCVDNIPVIYTAEVDCSIDKETGLENYIELKTHTKLADDKISTINKLNKKLLSTFIQTKFIDCQHSIIGFRSTDLKIASIKKYTQRELAGEINSFPVILSDKCSINTKSIFQWYKLIMNWIISKEITDHNTPQIFRLSFKRDQELMNSYLKLEKILQEDDNDTIFNDLVPEWFQSFIMNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMF0</accession>
    <name>C4YMF0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL29m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">54S ribosomal protein L4, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_02030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMF0"/>
    <dbReference type="PaxDb" id="5476-C4YMF0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02030"/>
    <dbReference type="HOGENOM" id="CLU_872105_0_0_1"/>
    <dbReference type="OMA" id="IRTTMWR"/>
    <dbReference type="OrthoDB" id="270763at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MRP-L47_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010729">
        <property type="entry name" value="Ribosomal_uL29_mit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183:SF18">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183">
        <property type="entry name" value="RIBOSOMAL PROTEIN L47, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06984">
        <property type="entry name" value="MRP-L47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="309" mass="36392" checksum="01970A8D5BBAD04A" modified="2009-07-28" version="1">MSLYSNIRTFSTRSIVLNRIKPLKFEDLTKIKLREPVVPRVANFEVSPDHPLWQFFPQGNKTKVAIRESEELDLDSREWSSAELRQKSFEDLHKIWYLTLKERNILSREVRLGESLGMGDFRQFNNVDRKLIKTQKRIKQVLLERQVAVERAQATMQDDIQEYLDDFKTRYVNCEADEVEDYHEKLVRLQYAIFGINPNLSLELLQDEETIDVNFVKGLSYIANLKVERHLKLNPQTEFELPLNGPVEELPFFLNDVEVVISQVKQLRDSGKSRMLHKIEVIPFLKQAIESHMQQEENIGGYEEEQNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMT8</accession>
    <name>C4YMT8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SCD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMT8"/>
    <dbReference type="PaxDb" id="5476-C4YMT8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02175"/>
    <dbReference type="HOGENOM" id="CLU_485707_0_0_1"/>
    <dbReference type="OMA" id="QINHFQN"/>
    <dbReference type="OrthoDB" id="2553626at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="58159" checksum="880C6D6C6DA485B7" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN85</accession>
    <name>C4YN85_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_02325</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YN85"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02325"/>
    <dbReference type="HOGENOM" id="CLU_000487_1_1_1"/>
    <dbReference type="OMA" id="KPCMGIV"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02584">
        <property type="entry name" value="RNAP_II_Rpb1_C"/>
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    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
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    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
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    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
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    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
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    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000001">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
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    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04990">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05001">
        <property type="entry name" value="RNA_pol_Rpb1_R"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 15 18" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="17">
        <location>
            <begin position="232"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1545"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1545"/>
            <end position="1732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ44066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1742" mass="193417" checksum="9188F65A5148D156" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNG0</accession>
    <name>C4YNG0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hyphally-regulated cell wall protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_01420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YNG0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01420"/>
    <dbReference type="HOGENOM" id="CLU_006199_1_0_1"/>
    <dbReference type="OMA" id="DTINTEY"/>
    <dbReference type="OrthoDB" id="4022214at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021031">
        <property type="entry name" value="Hyphal-reg_cell_wall_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11765">
        <property type="entry name" value="Hyphal_reg_CWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944830" description="Hyphally-regulated cell wall protein N-terminal domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="domain" description="Hyphally-regulated cell wall protein N-terminal" evidence="8">
        <location>
            <begin position="12"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="511"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1181"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1455"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="525"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1183"/>
            <end position="1192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ43193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1526" mass="161107" checksum="229934471D7E0593" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNI5</accession>
    <name>C4YNI5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7 9">2.1.1.216</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_01447</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7 9"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNI5"/>
    <dbReference type="PaxDb" id="5476-C4YNI5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01447"/>
    <dbReference type="HOGENOM" id="CLU_010862_4_0_1"/>
    <dbReference type="OMA" id="MKCCHEM"/>
    <dbReference type="OrthoDB" id="6349953at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.70:FF:000001">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000051">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="entry name" value="N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00308">
        <property type="entry name" value="TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 9" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ43218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="556" mass="62430" checksum="3B51355667EF6E02" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-24" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNR7</accession>
    <name>RSSA_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">40S ribosomal protein S0</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">RPS0</name>
        <name type="ORF">CAWG_02850</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNR7"/>
    <dbReference type="SMR" id="C4YNR7"/>
    <dbReference type="PaxDb" id="5476-C4YNR7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02850"/>
    <dbReference type="HOGENOM" id="CLU_058171_2_0_1"/>
    <dbReference type="OMA" id="VKNFFEP"/>
    <dbReference type="OrthoDB" id="414863at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000010">
        <property type="entry name" value="40S ribosomal protein S0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000389272" description="Small ribosomal subunit protein uS2">
        <location>
            <begin position="2"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="modified residue" description="N-acetylserine" evidence="1">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="261" mass="28730" checksum="17886B880D1A191C" modified="2009-07-28" version="1">MSLPASFDLTPEDAKLLLAANVHLGAKNVQVHNKPYVYKTRPDGMNIINIGKTWEKIVLAARIIAAVPNASDVAVCSSRTFGQRAVLKFAAHTGATAIAGRFTPGNFTNYITRSFKEPRLVVVTDPRTDAQAIKESSYVNIPVIALTDMDSPSEYVDVAIPCNNKGKHSIGLIWWLLAREVLRLRGIIPDRTTEWSVMPDLYFYRDPEEIEQNAVEEAKTEEVEEAPVAEAETEWTGETEDVDWADSGATPAAEDAAASNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPK2</accession>
    <name>C4YPK2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPK2"/>
    <dbReference type="PaxDb" id="5476-C4YPK2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02403"/>
    <dbReference type="HOGENOM" id="CLU_1758554_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="148" mass="15950" checksum="0380EC97EA97FF90" modified="2009-07-28" version="1">MSNFNSSANDSTSTAPTASTTTNGDIGLNFASPKKITALEAYTPERGSKGNPSGTNNNNNNTNNTNTNTTNNNNGKNTAGGPNTNQSSPAFWNFVQFSTPNGQSPVRKSSEEVGNNSPTLNRKIKRERENDETNSPFKKKQRTEMIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPL5</accession>
    <name>C4YPL5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">M-phase inducer phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_02416</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MPI phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPL5"/>
    <dbReference type="PaxDb" id="5476-C4YPL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02416"/>
    <dbReference type="HOGENOM" id="CLU_323369_0_0_1"/>
    <dbReference type="OMA" id="RRIHSMC"/>
    <dbReference type="OrthoDB" id="26523at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01530">
        <property type="entry name" value="Cdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000021">
        <property type="entry name" value="M-phase inducer phosphatase cdc-25.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF17">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="11">
        <location>
            <begin position="285"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="165"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="463"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="508"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="679"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="760"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="712"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="722"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="762"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ44154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="893" mass="99256" checksum="4EA061459C81F4AF" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPV0</accession>
    <name>C4YPV0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_02504</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPV0"/>
    <dbReference type="PaxDb" id="5476-C4YPV0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02504"/>
    <dbReference type="HOGENOM" id="CLU_007565_1_0_1"/>
    <dbReference type="OMA" id="EMTYQKQ"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22948">
        <property type="entry name" value="Coatomer_WDAD_alpha"/>
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    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000002">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000022">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047312">
        <property type="entry name" value="Coatomer_alpha_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016391">
        <property type="entry name" value="Coatomer_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010714">
        <property type="entry name" value="Coatomer_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF1">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06957">
        <property type="entry name" value="COPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003354">
        <property type="entry name" value="Coatomer_alpha_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="91"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="133"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="209"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="253"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="13">
        <location>
            <begin position="347"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="15">
        <location>
            <begin position="634"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="828"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="851"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="862"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR003354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEQ44239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1223" mass="138328" checksum="00314FCC1F1A4BF4" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPZ9</accession>
    <name>C4YPZ9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="4">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_02553</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPZ9"/>
    <dbReference type="SMR" id="C4YPZ9"/>
    <dbReference type="PaxDb" id="5476-C4YPZ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02553"/>
    <dbReference type="HOGENOM" id="CLU_012520_5_2_1"/>
    <dbReference type="OMA" id="ASEYRYA"/>
    <dbReference type="OrthoDB" id="15235at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000001">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="2"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="389"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="561"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ44288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="713" mass="79268" checksum="595EB8E90D704D53" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ34</accession>
    <name>C4YQ34_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ34"/>
    <dbReference type="PaxDb" id="5476-C4YQ34"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02588"/>
    <dbReference type="HOGENOM" id="CLU_2196566_0_0_1"/>
    <dbReference type="OMA" id="FIVEIYC"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="108" mass="12817" checksum="C5CB041E845F2B35" modified="2009-07-28" version="1">MFYYLETEVLATTYFIHKKEFTLMLFIVEIYCISRPIKSQIYPKSTKYLGLSISGELCCQKKYVRIKYLNIQTLFLRNKNFVRRSAGSPNQKKIKQKKTTSDVETKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQA0</accession>
    <name>C4YQA0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_02656</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQA0"/>
    <dbReference type="PaxDb" id="5476-C4YQA0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02656"/>
    <dbReference type="HOGENOM" id="CLU_075474_0_0_1"/>
    <dbReference type="OMA" id="MEYEAND"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15862">
        <property type="entry name" value="SNARE_Vti1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="104"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ44389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="174" mass="20021" checksum="E1BD62874CE16106" modified="2009-07-28" version="1">MVAFGEWDGFENFLVLEQRKNYLKSIEGANEEAREVLDQMTIEVSNLPSNQRSSYNAKIRNYRTELDTVTVTYNKLLDAQDKVELFGSNRYTDDSGDSSEQRKQLLSNNSSLERSSQRLHDSQRIAMETENIGSNILNDLRSQREQINGARNTLSQADNYVDRSVQTLKTMGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQK7</accession>
    <name>C4YQK7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_02766</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQK7"/>
    <dbReference type="PaxDb" id="5476-C4YQK7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02766"/>
    <dbReference type="HOGENOM" id="CLU_022080_0_0_1"/>
    <dbReference type="OMA" id="VHESSKM"/>
    <dbReference type="OrthoDB" id="10006572at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050937">
        <property type="entry name" value="TEC1_TEAD_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF0">
        <property type="entry name" value="PROTEIN SCALLOPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00065">
        <property type="entry name" value="TEADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00426">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00554">
        <property type="entry name" value="TEA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TEA" evidence="8">
        <location>
            <begin position="176"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="6">
        <location>
            <begin position="176"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ44496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="739" mass="82551" checksum="FF3FFE8F144EB1B6" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQP4</accession>
    <name>C4YQP4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_02803</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQP4"/>
    <dbReference type="SMR" id="C4YQP4"/>
    <dbReference type="PaxDb" id="5476-C4YQP4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02803"/>
    <dbReference type="HOGENOM" id="CLU_098356_1_0_1"/>
    <dbReference type="OMA" id="AFMWFLW"/>
    <dbReference type="OrthoDB" id="5423111at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032126">
        <property type="term" value="C:eisosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052649">
        <property type="entry name" value="NCE102-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165:SF1">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="6"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ44533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="170" mass="18123" checksum="CB8AC9D732D08858" modified="2010-10-05" version="1">MLAIGDVILRAFNFVFLVIALGLTGSLAATTITQHNPQINFAVFAAAFGLLTSSFYGVFAYFVAAFAWPVILFVFDFLNFVFTFAAATAIAAGIRAHSCSNQDYLDDNNIAQGSSGRCRKAQASTAFLYFSTFIFIASAIFSAISLSKGGLFGHSSRPAPRTGVPTMSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQQ0</accession>
    <name>C4YQQ0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_02810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQQ0"/>
    <dbReference type="PaxDb" id="5476-C4YQQ0"/>
    <dbReference type="HOGENOM" id="CLU_1408565_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ44539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="193" mass="23167" checksum="2B4356FBE3C61D76" modified="2009-07-28" version="1" fragment="single">MLFVPRKLAGKSETYTHHNKTKEKTATYTQISWRYIQHQPVPPPVPLNTIGSFKRLALSYQTKNFENPTKPNETEQKKKIYFTTTKQQQPFFYFDKYLQNYSFCFLTPKIKLNRKGKKIPSYKRKKLSSFSPIIIARSNTNQPTYIIFVVRKSLLSALFLFFYKKREFNRVQFPQFPQFLDIDFYIFYSVTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQU6</accession>
    <name>C4YQU6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GTPase activating protein BUD2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_04443</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
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            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatidylethanolamine-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQY9"/>
    <dbReference type="SMR" id="C4YQY9"/>
    <dbReference type="MEROPS" id="I51.001"/>
    <dbReference type="PaxDb" id="5476-C4YQY9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04486"/>
    <dbReference type="HOGENOM" id="CLU_043994_3_1_1"/>
    <dbReference type="OMA" id="HIDKRTR"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030162">
        <property type="term" value="P:regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.280.10:FF:000009">
        <property type="entry name" value="Carboxypeptidase Y inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001858">
        <property type="entry name" value="Phosphatidylethanolamine-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF148">
        <property type="entry name" value="CARBOXYPEPTIDASE Y INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01220">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="29346" checksum="6BBC190B57D512AC" modified="2010-10-05" version="1">MFNRSIRISRSPLLRSRTILPRTFVTNTHRLSYRLKQRNPSTIFKQSAMTLITISQSLDEAYTKHKVIPEVVDQFDTQGLLSIEYGPTELVTLGNTLSVEGTQEVPKIQLTLNSPTEDGKIESISENDKFILVMTDPDAPSNSDHKWSEYLHWLVTDLKLPHTKNEDGEPEISHFIDVKEGRELVPYMGPGPPPKTGKHRYVFLLYKQDPNAGELTAPKDRPNWGTGVPSSGVKDWIEKNAPNSKLLSVNFFFAQNEDN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-10-19" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR54</accession>
    <accession>P24866</accession>
    <name>CG11_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>G1/S-specific cyclin CCN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CCN1</name>
        <name type="synonym">CLN1</name>
        <name type="ORF">CAWG_04553</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1992" name="Proc. Natl. Acad. Sci. U.S.A." volume="89" first="9410" last="9414">
            <title>Dominant negative selection of heterologous genes: isolation of Candida albicans genes that interfere with Saccharomyces cerevisiae mating factor-induced cell cycle arrest.</title>
            <authorList>
                <person name="Whiteway M."/>
                <person name="Dignard D."/>
                <person name="Thomas D.Y."/>
            </authorList>
            <dbReference type="PubMed" id="1409649"/>
            <dbReference type="DOI" id="10.1073/pnas.89.20.9410"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-646</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDC2 protein kinase to form MPF.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="M76587">
        <property type="protein sequence ID" value="AAA34330.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S49206">
        <property type="entry name" value="S49206"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR54"/>
    <dbReference type="SMR" id="C4YR54"/>
    <dbReference type="PaxDb" id="5476-C4YR54"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04553"/>
    <dbReference type="HOGENOM" id="CLU_029626_0_0_1"/>
    <dbReference type="OMA" id="DEEMFIQ"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044843">
        <property type="term" value="P:cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000045">
        <property type="term" value="P:regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20537">
        <property type="entry name" value="CYCLIN_CCNO-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20559">
        <property type="entry name" value="CYCLIN_ScCLN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000010">
        <property type="entry name" value="G1/S-specific cyclin Cln1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014399">
        <property type="entry name" value="Cyclin_CLN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001770">
        <property type="entry name" value="Cyclin_CLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0195">Cyclin</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000413035" description="G1/S-specific cyclin CCN1">
        <location>
            <begin position="1"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="670"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="698" mass="79299" checksum="97F693A73BC77264" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR68</accession>
    <name>C4YR68_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heat shock protein STI1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_04567</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Part of a larger complex that includes HSP70, HSP90, and immunophilins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR68"/>
    <dbReference type="PaxDb" id="5476-C4YR68"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04567"/>
    <dbReference type="HOGENOM" id="CLU_000134_46_5_1"/>
    <dbReference type="OMA" id="MYSAREN"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000004">
        <property type="entry name" value="Putative stress-induced-phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000010">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000020">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000002">
        <property type="entry name" value="Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000027">
        <property type="entry name" value="stress-induced-phosphoprotein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="4"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="8">
        <location>
            <begin position="138"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="339"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="399"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="8">
        <location>
            <begin position="538"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="201"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="216"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00064323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ46221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="589" mass="66000" checksum="E6E5E684D8A2C404" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR81</accession>
    <name>C4YR81_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">pH-response regulator protein palH/RIM21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_04580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the palH/RIM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR81"/>
    <dbReference type="PaxDb" id="5476-C4YR81"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04580"/>
    <dbReference type="HOGENOM" id="CLU_026111_0_0_1"/>
    <dbReference type="OMA" id="CVVIPWE"/>
    <dbReference type="OrthoDB" id="5393256at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014844">
        <property type="entry name" value="PalH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH/RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH_RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08733">
        <property type="entry name" value="PalH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="364"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ46234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="529" mass="60071" checksum="B1D886DFA973C1E2" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRA0</accession>
    <name>C4YRA0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Origin recognition complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_04599</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRA0"/>
    <dbReference type="PaxDb" id="5476-C4YRA0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04599"/>
    <dbReference type="HOGENOM" id="CLU_007115_4_1_1"/>
    <dbReference type="OMA" id="QRIIYMP"/>
    <dbReference type="OrthoDB" id="343623at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001499">
        <property type="entry name" value="Origin recognition complex subunit 4, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016527">
        <property type="entry name" value="ORC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032705">
        <property type="entry name" value="ORC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14629">
        <property type="entry name" value="ORC4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="139"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ46253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="564" mass="64134" checksum="C9905CCB382DBBE9" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRN0</accession>
    <name>C4YRN0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Vacuolar aminopeptidase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_04732</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRN0"/>
    <dbReference type="PaxDb" id="5476-C4YRN0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04732"/>
    <dbReference type="HOGENOM" id="CLU_019532_3_1_1"/>
    <dbReference type="OMA" id="ANHEEIG"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000007">
        <property type="entry name" value="Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF4">
        <property type="entry name" value="VACUOLAR AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ46383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="64582" checksum="4504D505C262870C" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRN6</accession>
    <name>C4YRN6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_04738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRN6"/>
    <dbReference type="SMR" id="C4YRN6"/>
    <dbReference type="ESTHER" id="canal-q59nx8">
        <property type="family name" value="Steryl_acetyl_hydrolase"/>
    </dbReference>
    <dbReference type="ESTHER" id="canaw-c4yrn6">
        <property type="family name" value="Steryl_acetyl_hydrolase"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YRN6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04738"/>
    <dbReference type="HOGENOM" id="CLU_053543_0_0_1"/>
    <dbReference type="OMA" id="LMWFTER"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010424">
        <property type="entry name" value="EutQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019436">
        <property type="entry name" value="Say1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169:SF1">
        <property type="entry name" value="ACETATE KINASE EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169">
        <property type="entry name" value="ETHANOLAMINE UTILIZATION PROTEIN EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10340">
        <property type="entry name" value="Say1_Mug180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="42100" checksum="625503AFF67957EC" modified="2009-07-28" version="1">MTIYKTALTIPVRDSGLFSIMSNYFIINKLIKTLYPTLTSLPNYGKKYDKQSYWLVESKDRKPSDPVLIFLHGGGYFVQTMPSQIESLLSIYHLLEEPQKSKLSILVLDYKLACHGYKVPYQLTELIDTYTNLVKDGSKNILLMGDSAGGNLALIFLQSLKIDKLSLPYPSSVLLISPWVKLAPDNFQNTPGNSYYDNAAHDMLPFNSHSSELLESLLGDSRVYSLTISPGNCPYNETDWKDIPSLNHPGYSVFVITGEHECFRDDILEWANHSLQSPLTPQKGDSQGRFNPKIHQYIRDTPDTAYAEVLIEPCGVHDSVLYFENSIISILKNNPRLNAKSLDKVEYFGITKVVDFLNKTLSSEEKKGVKPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRT0</accession>
    <name>C4YRT0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_04787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRT0"/>
    <dbReference type="PaxDb" id="5476-C4YRT0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04787"/>
    <dbReference type="HOGENOM" id="CLU_653797_0_0_1"/>
    <dbReference type="OMA" id="YGDDESF"/>
    <dbReference type="OrthoDB" id="4009323at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="420" mass="49226" checksum="7467BB9B948213EE" modified="2010-10-05" version="1">MKIFEALLELQNTLLKYYSATIQYLYHELLTLFENKVSIDVEKPDLERISFYTSLIEKYQYQIIQLTDFNKGHTIYMTLQQIINSGIQDVLVTITALRNSEQKLIRVSSEALLIQPGIEEKLKWIINENNHLHNFQNDQDRYQAFFARLKNEINDVPPPQYTCSSLNKFVEDIVNEYSLDIPVLEIVIDKLNRNHSEEELYLEKLQNTILQHILEQEVDTSSVSFTEQEIKVIDIMEILTAHIDFFKRLSKIYIKFDKLLLQKLRLDNLPAPESVEINSHIAKKLDNFIANLVAGGTVGLSTEQTYISVFSFIQNIAFQFRTFNENYIGYIPESRPARYGDDESFWTLVKEYIATLLRVTKFLEDPNGCNHDVNIIMGSSKEEFEQLENEAREYFFALLPFERIFECDERIVNHQLGEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSD3</accession>
    <name>C4YSD3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein ORM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04996</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSD3"/>
    <dbReference type="SMR" id="C4YSD3"/>
    <dbReference type="PaxDb" id="5476-C4YSD3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04996"/>
    <dbReference type="HOGENOM" id="CLU_072117_0_0_1"/>
    <dbReference type="OMA" id="STHYTHF"/>
    <dbReference type="OrthoDB" id="1932233at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007203">
        <property type="entry name" value="ORMDL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12665">
        <property type="entry name" value="ORMDL PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04061">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ46636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="268" mass="29661" checksum="54A49FFE003449D6" modified="2010-10-05" version="1">MTDVSPNSKIEHLTPDNITVTAPSEPPFSSSSSTSASASTPTPIAEEKLSTPIPTPSPSHRRGSSIGSSTSPSSSTRNRSNSNSANALTPTPSHHQPAHSITRQRRSSSLIQHLEPDTLDTKIDQALNPNVNANWVHQKGAWVIHVVIIILVKMIFNFISVLNNDWKWTLTNLTYNIGSYIMFHQVKGTPFEFNSGAYDNLTMWEQIDNGDQYTPSKKFLMLVPIGLFLISTHYSSYNLNLFILNGLSCLCVVVPKLAFAHRLRVTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSH9</accession>
    <name>C4YSH9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_05045</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BMT family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSH9"/>
    <dbReference type="PaxDb" id="5476-C4YSH9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05045"/>
    <dbReference type="HOGENOM" id="CLU_013841_1_0_1"/>
    <dbReference type="OMA" id="VYIVYQW"/>
    <dbReference type="OrthoDB" id="3631276at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021988">
        <property type="entry name" value="BMT1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12141">
        <property type="entry name" value="BMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="662"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="662"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="767"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ46682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="780" mass="90833" checksum="0408A3F263B82C0F" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSJ9</accession>
    <name>C4YSJ9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_05067</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSJ9"/>
    <dbReference type="PaxDb" id="5476-C4YSJ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05067"/>
    <dbReference type="HOGENOM" id="CLU_003488_0_0_1"/>
    <dbReference type="OrthoDB" id="1845386at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007810">
        <property type="entry name" value="Pep3/Vps18_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058919">
        <property type="entry name" value="Pep3/Vps18_RING_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF26">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05131">
        <property type="entry name" value="Pep3_Vps18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26148">
        <property type="entry name" value="VPS18_RING_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pep3/Vps18 beta-propeller" evidence="8">
        <location>
            <begin position="39"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="512"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Pep3/Vps18 RING C-terminal" evidence="9">
        <location>
            <begin position="764"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ46702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="811" mass="94567" checksum="7062E705AE58A5AA" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSM5</accession>
    <name>C4YSM5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pantothenate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_05093</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSM5"/>
    <dbReference type="PaxDb" id="5476-C4YSM5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05093"/>
    <dbReference type="HOGENOM" id="CLU_011154_3_1_1"/>
    <dbReference type="OMA" id="WSKGAKQ"/>
    <dbReference type="OrthoDB" id="498611at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000115">
        <property type="entry name" value="Pantothenate kinase PanK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.510:FF:000015">
        <property type="entry name" value="Pantothenate kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00555">
        <property type="entry name" value="panK_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF20">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ46728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="48036" checksum="A64C407BBEDA96FA" modified="2009-07-28" version="1" fragment="single">VEDDENQLQQLQQQPLYGGVITKNNITLPQHNDEIIHISVDIGGTLTKLVYFTKSSSNRKNSSRKTTGGGGGGKLHFQDFQTENFKNEAMKFMIKLIQKSINKSNINPPITYIMATGGGAHKFYNLMKKTFKKHKLPMKIIAKDEMECLIKGLDWLITKIPQEIFTYDLTELTTKFEPIQSKKEIYPYLLVNIGSGVSMVKVTKPGPEGFERIGGSSLGGGTLWGLLSLLTDAKDYNEMLEMAQNGDNENIDLLVGDIYGTNYNKIGLKANHIASSFAKVFKKLRKFNSSTNSNNNNNSDNDSDGKFKKLTAAEKLAQFKQEDIARSLLFSISNNIGQIAYLHALRFNLKRIYFGGSYISGHMQTIHTLSYAVNFWSKGEMQSYFLRHEGYLGSVGAFMMGPAPILEENGNSSNENNHTNNVKIANGVQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSP7</accession>
    <name>C4YSP7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSP7"/>
    <dbReference type="PaxDb" id="5476-C4YSP7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05115"/>
    <dbReference type="HOGENOM" id="CLU_1740255_0_0_1"/>
    <dbReference type="OMA" id="KLEYFCS"/>
    <dbReference type="OrthoDB" id="5277092at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="150" mass="17024" checksum="2DE1CC0D2FF374FC" modified="2010-10-05" version="1">MGWFSFSSSNKESSVSTVFPPSQQIEQRSHQSLNLPQGSDIATTLNQLSSQTGNDQEVKVKEIDNIQDKNEIEKTVESFVESYPISNMFVIDGEKDSKQSIICTTTDSGKTCLKLKMNSIQLFKIMQKQEYFCSLPDDINATYFECRKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSP8</accession>
    <name>C4YSP8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_05116</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the assembly of mitochondrial and cytoplasmic iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSP8"/>
    <dbReference type="PaxDb" id="5476-C4YSP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05116"/>
    <dbReference type="HOGENOM" id="CLU_069054_0_1_1"/>
    <dbReference type="OMA" id="TSKWARH"/>
    <dbReference type="OrthoDB" id="333486at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000001">
        <property type="entry name" value="Iron-binding protein IscA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050322">
        <property type="entry name" value="Fe-S_cluster_asmbl/transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072:SF41">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="5">
        <location>
            <begin position="166"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="64"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00071673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ46751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="269" mass="29687" checksum="FE465BE32985B7BA" modified="2009-07-28" version="1">MMIATRRQSLQLTKRYISNHATKNKRFIQTIPISTNTGSNSFLSKLHQSESNGAPTSKWARHTLSFPKTETSNTTPQPPVRKSRTSRFANKSQSANETKPFNSSITPTPQSNIIEITSDPEIQKASNKITTSTASVPTDSNKSQSTAAPSVTPKKKRVLRPRKALITLTSSAVQHLQGLLDQPDPKLIRIGVRNRGCSGLTYNLEYVDKPGKFDELVEQDGVKVLIDSKALFSIVGSEMDWLDDKLSSRFIFKNPNSKGTCGCGESFMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YST1</accession>
    <name>C4YST1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WDR5-like beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_05150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YST1"/>
    <dbReference type="PaxDb" id="5476-C4YST1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05150"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_1_1"/>
    <dbReference type="OMA" id="NYALKCT"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002270">
        <property type="entry name" value="Subunit of the COMPASS complex, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059122">
        <property type="entry name" value="Beta-prop_WDR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25175">
        <property type="entry name" value="Beta-prop_WDR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR5-like beta-propeller" evidence="5">
        <location>
            <begin position="28"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="64"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="107"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="151"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="216"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ46784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="383" mass="42329" checksum="58CC6CB22A4BB749" modified="2010-10-05" version="1">MGIPILSSDIQQSDLYKIRYTINEPSITFTAVKFSPNGQNFACSSSNGKIYIYNTTTGKLITTLSGHTKGISDIVYSPINSNILASCSDDLTIRLWNITQQRCIKILRKHTYHITTLKFTQKGNILISGSSDETITIWDITSNGGKILTTLAAHSDPVSSIALTPDDSIIVSASYDGLMRLFDLQTSQCLKTLTNSTFGGHGTATASTNDVINFPIAKVELSPNGQFILNSSLDGKIRLWNYMENKVYKTYQGINSEKICEKFNCDIKFITRNVNSNAITITSNNNDDEQYNNVLIVSGSDSTGLLIWDIQSKQIVFQVDPQTCGKDAILGVDTYKQGEILGCCSRDGIITILDMNKKYTERNDSVQQQKEVIDTESRGETPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT76</accession>
    <name>C4YT76_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="19">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CAWG_05362</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="19"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT76"/>
    <dbReference type="PaxDb" id="5476-C4YT76"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05362"/>
    <dbReference type="HOGENOM" id="CLU_011312_1_0_1"/>
    <dbReference type="OMA" id="WQTMGIL"/>
    <dbReference type="OrthoDB" id="272481at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.40:FF:000001">
        <property type="entry name" value="DNA repair helicase (Rad3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.30:FF:000001">
        <property type="entry name" value="DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000381">
        <property type="entry name" value="TFIIH basal transcription factor complex helicase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.20">
        <property type="entry name" value="Bacterial XPD DNA helicase, FeS cluster domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042493">
        <property type="entry name" value="XPD_DNA_FeS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 23" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="22">
        <location>
            <begin position="7"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="257"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EEQ46817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="701" mass="80346" checksum="353F7A9A908C8872" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT78</accession>
    <name>C4YT78_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase-associated protein LEO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT78"/>
    <dbReference type="PaxDb" id="5476-C4YT78"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05364"/>
    <dbReference type="HOGENOM" id="CLU_052544_0_0_1"/>
    <dbReference type="OMA" id="TIRWRYG"/>
    <dbReference type="OrthoDB" id="20844at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007149">
        <property type="entry name" value="Leo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146">
        <property type="entry name" value="LEO1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146:SF0">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN LEO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04004">
        <property type="entry name" value="Leo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="37215" checksum="D391F3C3B4A6E345" modified="2009-07-28" version="1">MSDEEIDDLFGEETTEKIVDLSLPRHAVVSVMEKDVRLLKTPDFLNIEAHPFDPSSFKEQIESNNKARRERGLTAKEIHNEQMTEKLLNENTIRWRYHNAGNDEIVKQSNAHFVEWSDGSVSLKVGNEVYDVRELPMFDHLLVKSHQAAEVLQADSILSKSINLLPASSSHRKILVKNITKKEKILNTITDVDPLEKQRLADEDVRKAMKMKRQMESRRRLQEEKWERSGSPRAQESSYERFERTYEGEGYDENDDFVAGDEEEIEEYEEEEEFERGAERLTQLKEEGAAKYRRHSEDEDEDEKTRKRRRIIDSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTG1</accession>
    <name>C4YTG1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_05453</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTG1"/>
    <dbReference type="SMR" id="C4YTG1"/>
    <dbReference type="PaxDb" id="5476-C4YTG1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05453"/>
    <dbReference type="HOGENOM" id="CLU_041575_4_2_1"/>
    <dbReference type="OMA" id="KTFGPHP"/>
    <dbReference type="OrthoDB" id="275876at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000018">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein YmL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ46902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="278" mass="31684" checksum="A5FDEC6C1E11D050" modified="2010-10-05" version="1">MFKQSIRSLATKSPISSAAATTTTASTTSTTTTASLNFAKPPSYTLAQLREFPSLEPKTFIPLPTTFFNTEKPIRRDILWSCVTYEADKARVGSNYAILKSDSPYSNRKLRPQKGSGRARLGDANSPHMDNEIKAHAIKGPHDWSTDLPSKIYSRGIQNAFTMHYKQGNLNVVENELDFQYGYDIITQSFVSVHNLNKLNLLFITNEPRDNLMESIKKFYINEKEFNSLNKKEKPKYLQKLKGKVLTKEDVEVRDILRAHRVFIESSALQWFITKHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTG2</accession>
    <name>C4YTG2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">40S ribosomal protein S18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_05454</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTG2"/>
    <dbReference type="SMR" id="C4YTG2"/>
    <dbReference type="PaxDb" id="5476-C4YTG2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05454"/>
    <dbReference type="HOGENOM" id="CLU_103849_0_1_1"/>
    <dbReference type="OMA" id="SYKGVRH"/>
    <dbReference type="OrthoDB" id="1702480at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.910.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ46903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="145" mass="16990" checksum="D422BCC8BF793EC3" modified="2009-07-28" version="1">MPLVVQEQGSFQHILRLLNTNIDGRIKIMYALTKIRGVGRRYANLVCKKADVELTKRAGELTQEELERIVTIMQNPTNYKIPAWFLNRQKDQVDGKDYHVLANNLESKLRDDLERLKKIRSHRGIRHFWGLKVRGQHTKTTSRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTM3</accession>
    <name>C4YTM3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_05518</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTM3"/>
    <dbReference type="PaxDb" id="5476-C4YTM3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05518"/>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="OMA" id="GAKCSVI"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF4">
        <property type="entry name" value="AMIDASE C550.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="103"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="255"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ46964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="579" mass="64811" checksum="E58565BBDD1EA4B8" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C5K446</accession>
    <name>C5K446_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="11">High-affinity glucose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_06149</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG670278">
        <property type="protein sequence ID" value="EEQ43128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C5K446"/>
    <dbReference type="SMR" id="C5K446"/>
    <dbReference type="PaxDb" id="5476-C5K446"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06149"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="32"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ43128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="545" mass="60656" checksum="B8F195062F9CBF28" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCR2</accession>
    <name>C4YCR2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_00296</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YCR2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00296"/>
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    <dbReference type="OMA" id="DWEYMDK"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060258">
        <property type="term" value="P:negative regulation of filamentous growth"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12194">
        <property type="entry name" value="Kcc4p_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14081">
        <property type="entry name" value="STKc_BRSK1_2"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Probable serine/threonine-protein kinase KCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Serine/threonine-protein kinase HSL1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Fungal kinase associated-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Fungal_KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043024">
        <property type="entry name" value="KA1_sf_fungal"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
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    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16797">
        <property type="entry name" value="Fungal_KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="28"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="366"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
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            <begin position="510"/>
            <end position="532"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="564"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
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            <begin position="711"/>
            <end position="736"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="15">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1010"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="663"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="369"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
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            <begin position="426"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="569"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1023"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1043"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1082"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1133"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
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            <begin position="1201"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ42098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1348" mass="152783" checksum="524BF985A4586BFC" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCU9</accession>
    <name>C4YCU9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peroxin/Ferlin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_00333</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EEQ42135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="GFSRYTR"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052646">
        <property type="entry name" value="Peroxisomal_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="6">
        <location>
            <begin position="268"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ42135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="396" mass="46578" checksum="51FF29D7D0B96FBE" modified="2009-07-28" version="1">MPEFKSHIRATFEPTDTKLLTNTPTSRLLTESPKLSTALSQIFPYLLLIDNLLEILTWTNEDHYQNFLLLTCYSCIIVYWNWVSHVILPILMTLAFSSIVWFISSIIYDSKYDEKPTIEEVLYTLHNITIRCEMLLRPIKHVPIQRKHFIKLVIASIFLTPLNFAVSKTLIPPQKYILFLGLFLFTFHSPYSFAIRRLLWRSLYVRIAILYITGLDIKIRKDYDPNDYQTVSRVASASNSDAEGLGGIPVLSDFKIIKKRVVSPTQLKQTVVFEILENERRWLGVGWSSLLYPSERPNFCYEGSYNLAPNITVHKENFPFPVFENDLYAYSWEWIDDDWSLELEYQKSKAHVGWVYFDSNWGNGRVRDGFSRYTRSRKWTRRATLIIDKRETVYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCY2</accession>
    <name>C4YCY2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TATA-box binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_00368</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCY2"/>
    <dbReference type="PaxDb" id="5476-C4YCY2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00368"/>
    <dbReference type="HOGENOM" id="CLU_060161_4_2_1"/>
    <dbReference type="OMA" id="FHFKIAE"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ42168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="238" mass="26631" checksum="D7C5EB6FB276F4FE" modified="2009-07-28" version="1">MDLKLPPTNPTNPQQAKTFMKSIEEDEKNKAEDLDIIKKEDIDEPKQEDTTDSNGGGGIGIVPTLQNIVATVNLDCRLDLKTIALHARNAEYNPKRFAAVIMRIRDPKTTALIFASGKMVVTGAKSEDDSKLASRKYARIIQKLGFNAKFCDFKIQNIVGSTDVKFAIRLEGLAFAHGTFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKKREEIYDAFESIYPVLNEFRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD08</accession>
    <name>C4YD08_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein kinase CBK1</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_00395</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. COT1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD08"/>
    <dbReference type="PaxDb" id="5476-C4YD08"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00395"/>
    <dbReference type="HOGENOM" id="CLU_000288_67_2_1"/>
    <dbReference type="OMA" id="HDNAYYQ"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000920">
        <property type="term" value="P:septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21773">
        <property type="entry name" value="MobB_CBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000086">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000828">
        <property type="entry name" value="Serine/threonine-protein kinase CBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000192">
        <property type="entry name" value="Serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF76">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_135, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="333"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="16">
        <location>
            <begin position="646"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="111"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="11"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="119"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ42194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="730" mass="84214" checksum="8668639CDF02EB0A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD87</accession>
    <name>C4YD87_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_00477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00477"/>
    <dbReference type="HOGENOM" id="CLU_030612_3_1_1"/>
    <dbReference type="OMA" id="SMWQGYY"/>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF11">
        <property type="entry name" value="AER338CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ42273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="407" mass="46602" checksum="45084FB413327634" modified="2009-07-28" version="1">MISRTSMFRSIVENAQSTLKQQITNIPKSAGTNYQNFVNLNDVQKREVLTAIQSLKSYETSSKAQNDRRRKLFQRMSYKQQKACKDIGYLKKLDKIDNAISANYKFVDDVADHAIAKYGISLKDFDLLNSEKKNASTTSASNYRVIEALGHYTRDWHPENIGLELLPMYEYVASQLSALIPYDAKKDTCLVFPGSGLGRLAHAFAKWDFGAVHSIEYSGLMNAFVDFNYTKSDKNYTLYPYVHTCSDFYSTESQLRTFEFKPLGEIPETLHIHNQDFRHFKIPNRDSYKNIVVVTAFFIDTAENLLDYLDVIKNLTLPSGNIDRGYWINVGPLKYGTAAQVELNADELKDLRKNLGWKDYNSVYTIYDKLSAGDKTGLVGYLTDKESMWQGYYGLNMFASGREENKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDK7</accession>
    <name>C4YDK7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_00604</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDK7"/>
    <dbReference type="PaxDb" id="5476-C4YDK7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00604"/>
    <dbReference type="HOGENOM" id="CLU_004300_0_0_1"/>
    <dbReference type="OMA" id="DCWRREL"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000007">
        <property type="entry name" value="C6 transcription factor FacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF12">
        <property type="entry name" value="REGULATORY PROTEIN CAT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ42393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1056" mass="118908" checksum="698F760EE2FF7B80" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDM4</accession>
    <name>C4YDM4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="13">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_00621</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="13"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDM4"/>
    <dbReference type="PaxDb" id="5476-C4YDM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00621"/>
    <dbReference type="HOGENOM" id="CLU_033536_13_3_1"/>
    <dbReference type="OMA" id="KCFRREV"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006720">
        <property type="term" value="P:isoprenoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000036">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 13 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="7"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ42410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="239" mass="26862" checksum="601B5459DD193B0B" modified="2010-10-05" version="1">MTQNKYSVILPTYNEKRNLPILIYLLNKTFTANKLDWEVIIVDDNSPDGTQEIAKKLIDIFGPEHIQLRPRAGKLGLGTAYVHGLQFVTGNFVIIMDADFSHHPEAIPEFIAKQKSQDYDIVTGTRYAGDGGVFGWDFKRKLISRGANFLASVVLRPHVSDLTGSFRLYKTDVLKKIIDVTQSKGYVFQMEMMVRAKAMGFTVGEVPISFVDRLYGESKLGGDEIVQYAKGVWTLFTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDQ0</accession>
    <name>C4YDQ0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GDP-mannose transporter</fullName>
            <shortName evidence="5">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_00647</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDQ0"/>
    <dbReference type="PaxDb" id="5476-C4YDQ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00647"/>
    <dbReference type="HOGENOM" id="CLU_025360_1_2_1"/>
    <dbReference type="OMA" id="VWMLINC"/>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ42436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="338" mass="37157" checksum="DCCFC9E1B4F538F9" modified="2009-07-28" version="1">MDSKHSTSSSSSGSLATRISNSGPISIAAYCLSSILMTVTNKYVLSGFSFNLNFFLLAVQSIVCIVTIGSLKSLNIITYRQFNKDEAKKWSPIAFLLVAMIYTSSKALQYLSIPVYTIFKNLTIILIAYGEVIWFGGKVTTMALSSFLLMVLSSVIAYYGDNAAVKSHDDAFALYLGYFWMLTNCFASAAFVLIMRKRIKLTNFKDFDTMYYNNLLSIPILLICSFIFEDWSSANVSLNFPADNRVTTITAMILSGASSVGISYCSAWCVRVTSSTTYSMVGALNKLPIALSGLIFFEAAVNFWSVSSIFVGFGAGLVYAVAKQKQQKEQSQQLPTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDX1</accession>
    <name>C4YDX1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_00719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
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        <property type="protein sequence ID" value="EEQ42574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YE38"/>
    <dbReference type="PaxDb" id="5476-C4YE38"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00791"/>
    <dbReference type="HOGENOM" id="CLU_016174_0_0_1"/>
    <dbReference type="OMA" id="TINDCAY"/>
    <dbReference type="OrthoDB" id="4021105at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ42574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="451" mass="51986" checksum="08F19DDE26DA70C3" modified="2009-07-28" version="1">MLEYLSLNSLGFTSFYALEMNFPNLKTLILTGCEGLSEYDGLEDCQHLKHLTINDCAYPFEIFNETRFLELESFEYSGSGYINPKYFEKENLTFPPNLKQLSIKTSDFVNVRSSQIVFPTSLIRLELLDVSFIDQYFHLDDNLQYIHIETPKLLFDNKFNIPSMTEELILKADYLIFESPNFMYSLPKNLLRLHLIADKQGKMSSFIQTIKWPLIVSDFAIKGFNIDYKTLKLLNLKESRLREINVYQGNVKVLDTDLFPISVEYFTLSHMGIHKLPVSLEELKNLQKLSLSGNQFRKINSVKLPISPLIDIDLSQCNLGLVSPFLVSMFEEKNRNPKLRVNATGNLNINISDIKRALKIIKGLSLELNKFNEALTEISKHSSRLHCISQLVDPYFEESTTEKIVGSDYDPEDLYNGSDFNSDEEEIDYVIAPVTEDESEEESEEDIEEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YE57</accession>
    <name>C4YE57_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_00810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YE57"/>
    <dbReference type="PaxDb" id="5476-C4YE57"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00810"/>
    <dbReference type="HOGENOM" id="CLU_478949_0_0_1"/>
    <dbReference type="OMA" id="SAHAGCD"/>
    <dbReference type="OrthoDB" id="4027675at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944155" evidence="2">
        <location>
            <begin position="20"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="451"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="565"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ42593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="590" mass="61400" checksum="C176A9F041D60B33" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YE67</accession>
    <name>C4YE67_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pirin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_00820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YE67"/>
    <dbReference type="PaxDb" id="5476-C4YE67"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00820"/>
    <dbReference type="HOGENOM" id="CLU_045717_0_1_1"/>
    <dbReference type="OMA" id="GRMRHRD"/>
    <dbReference type="OrthoDB" id="198735at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="5">
        <location>
            <begin position="28"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="6">
        <location>
            <begin position="173"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006232-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ42603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="35951" checksum="0E903D61DE0D3092" modified="2009-07-28" version="1">MSVRSIAKVVTPNPPRPGSPVKIRNSIGSSNQFNPFLLFDHFTIPSTGGFPAHPHRGQETITLVLKGGVAHEDFTGSKGVLYPGDLQFMTAGKGVVHSEMPVPNEDGSPSVGLQLWVDLPNNMKDVKPRYRDLREWEIPQVVADDGKVIVKVISGKSHGVESQKELAYTPINYYHYKVKAGGKFKQELSPGFNYFLYVLNGKNLKLNGNTTVDKYQTAFFNETGDYITGENTATEETEANESEFVLIGGKILNQKPVQYGPFVASSKTGITKALLDYELARNGFEHRVKWNSLISRGVNKSMVTGPLNGCPKKRAADKKSYLDSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEC7</accession>
    <name>C4YEC7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_00884</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00884"/>
    <dbReference type="HOGENOM" id="CLU_731585_0_0_1"/>
    <dbReference type="OMA" id="THQGHII"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172:SF24">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172">
        <property type="entry name" value="OS01G0976800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="276"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="398"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="160"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="413"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ42663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="446" mass="48098" checksum="6FC2EFE5E54A376F" modified="2009-07-28" version="1">MSSSSSLSSSTTTATATSARIRLPSISELTSRSTISGGSNSGNGSALKSQISPRLSDTSRILPSILKNTSGSSTPTSSSTPFKCPPIKSTVGGTLSSGNTQSNYVLGNTKINSLPRLSSPTLPVKVQPQQQPQLPPASSLSPVTRVINTPPQQPQSVSASTSPNTQYQYYQYQQQSSPIQQQQQQQQATPAATPTVMQMAQNQPSHPAPLQYATQQYYPQPVYYQSPAGVPPPPPSVTHQGHIIAVHQHPGHLPQVGVNGMPPNVGYTIVQPEIVNKSTNRCHRCGTTETPEWRRGPKGVRTLCNACGLFHAKLVKRKGAALAAEEVLNNKVTKGKNGRRISMKKHLLNESLKQQQQINGVGIPINGFNHQILPPSFKPQQGGIATLPPLMHGQYPNNVNNLVIHQPPPPPQQQQQQQPRPQQQQQHMLAGGIPVAYPTQIPLIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YED0</accession>
    <name>C4YED0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="8">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_00887</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="8"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YED0"/>
    <dbReference type="SMR" id="C4YED0"/>
    <dbReference type="PaxDb" id="5476-C4YED0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00887"/>
    <dbReference type="HOGENOM" id="CLU_030903_0_1_1"/>
    <dbReference type="OMA" id="QPLVMEN"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF12">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, TYROSINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="9">
        <location>
            <begin position="49"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ42666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="370" mass="40291" checksum="11E5E324C8D7B6DB" modified="2009-07-28" version="1">MSKTPVPTEYDDTRILGYDPLVPPALLQHEIKASAESLDVVIKGRYDSAQILKGNDDRCIVIVGPCSIHDPPQALEYGKRLKKLADELKDDLVIIMRAYLEKPRTTVGWKGLINDPDVDNSFDINRGLKISRQLYSDLTSVVGLPIGSEMLDTISPQYFSDFLSFGAIGARTTESQLHRELASGLSFPIGFKNGTDGGLAVALDAVQASSKGHHFMGVTKNGMAAITTTKGNDCCFIILRGGKKITNYDVESVKAAKEAIAKCTDPSIKLMVDCSHDNSRKDYRNQPQVLDSVAEQISNGEDSIIGVMIESNIHEGKQPMPPAGSGKEALKYGVSITDGCVSWETTVEMLTKLSQAVQTRRSLKKQKVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEE9</accession>
    <name>C4YEE9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_00906</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEE9"/>
    <dbReference type="PaxDb" id="5476-C4YEE9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00906"/>
    <dbReference type="HOGENOM" id="CLU_015387_0_1_1"/>
    <dbReference type="OMA" id="IWGDKEM"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000033">
        <property type="term" value="F:alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392:SF1">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="617"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="731"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="649"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="737"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ42685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="758" mass="89188" checksum="3BAB5235E8BED6CE" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEI6</accession>
    <name>C4YEI6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEI6"/>
    <dbReference type="PaxDb" id="5476-C4YEI6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00943"/>
    <dbReference type="HOGENOM" id="CLU_569848_0_0_1"/>
    <dbReference type="OMA" id="ERETMDQ"/>
    <dbReference type="OrthoDB" id="4022350at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="479" mass="55948" checksum="81219D128681FBE3" modified="2009-07-28" version="1">MGFINPGKSLRKRKSRSNSPLPAKIPKVSPFLSQPQSQYAPAISLITLPVEIIHKIFVYVGPSENYLPLVNKHMYSILRFNGDIQAESICNYPLLKSMVNSYFFFDLNIRINDQCLQMKLKYYNTKLESIQQQYSDYTRSSHYNRIRENLTIVKSTVQSFHQNRYALLVDILNFKFVSSQVLYRLRKERETMDQGLPIRSMAEIILLQKSRLKFLRLKFNEMGVNLKRLLSEIDSGSIETSVNFDVESIQRSLLDEPEDDLNPPFQYFEDENLPTEGFSSCTNDKYIKESEGFLHFNEGFETIEDEAPGRSKLPELLFIKSMYSTRHYDTLNYLKSFYKFGKIDGPKAITGLLNVLESPHKYQVLNWSQLRSLVDCVCACNNPQYKFTEAIVSSFRLYAHYKSKDHPLPFDIKVNIADAINMILQMIETLVEHFFAHDHNNEERRQLWIEAMQLKDICLTDLLGEYDDNPDYDILHRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF63</accession>
    <name>C4YF63_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF63"/>
    <dbReference type="PaxDb" id="5476-C4YF63"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01175"/>
    <dbReference type="HOGENOM" id="CLU_038964_1_0_1"/>
    <dbReference type="OMA" id="FRKEVCH"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF294">
        <property type="entry name" value="POTENTIAL PROTEIN LYSINE METHYLTRANSFERASE SET6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="24"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="379" mass="43922" checksum="2EF2D29C0340C622" modified="2009-07-28" version="1">MAASEESTLVDEYPIKSILNQISPWFIVDETKYGGRGCFATKVIPQHTVIHSCQTPIGSTLSKPFKKEVCSQCYTYTYGETMKFKISKTEGKHVYSLFFCSEECKSTFTHQDINRVLVENLLAVEKNYLAGLSKPEIEPMEPKNFADDYVKEWDKVASWETKLESLKPSKRQNQIFRIDDNEYLEIKYVIGVLFNMYKVHCNDHIPHFDYPNLDKNEANKVELLLFDLLYSSEFEKVKRYPYLLYSYINIYKFIKLTCTPELQAFIDSTTIRSIIGKNLSNAFGIWSEVTDPSEDKEFLGFGVYPSASFFNHSCSPNIVKTRNNSEMVFTTSKDIEIGEELCISYGNYTDEPVELRQKQLKEWFFDCACTKCQTELKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF96</accession>
    <name>C4YF96_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="6">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_01209</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 8">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF96"/>
    <dbReference type="PaxDb" id="5476-C4YF96"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01209"/>
    <dbReference type="HOGENOM" id="CLU_052104_1_0_1"/>
    <dbReference type="OMA" id="VIICITE"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000005">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="9">
        <location>
            <begin position="26"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6 7">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="39"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="118"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ42982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="323" mass="33707" checksum="4187A676205B5ACC" modified="2009-07-28" version="1">MYRQFTRGFSSSLPARNYASTIKNLKVTKDTKVIYQGFTGKQATFHAEQAIAYGTDVVGGINPRKAGTTHLDRPVFGTVAEAMKEAGASATGIFVPPPLAAAAIEEAIAAEIPLAVAITEGIPQKDMVRISQILKTQEKTRFVGPNCPGLIAPDQCKIGIMPSSIHQRGKVGVISKSGTLTYEAVAQTTAVGLGQSLVIGMGGDPFPGTNFIDALTLYLNDPETEGIIMIGEIGGSAEEEASEFLKQHNLTRPEGPKPVVGFIAGVSAPPGRRMGHAGAIVAGGKGDAKSKIAALESAGVVVEKSPARLGNSLLAEFKNKNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFA6</accession>
    <name>C4YFA6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_01220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFA6"/>
    <dbReference type="PaxDb" id="5476-C4YFA6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01220"/>
    <dbReference type="HOGENOM" id="CLU_085878_2_0_1"/>
    <dbReference type="OMA" id="TMRQPGL"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="84"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ42992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="173" mass="19174" checksum="DABAD17751328219" modified="2009-07-28" version="1">MFFLKDLSLNLTLHPSFFGPQMDQYLREKLLSDVEGTCTGQFGYIVCVLDSMNIDVGKGRIIPSTGKVEFEVKYRAVVWKPFKGEVVDAVVTTVNKMGFFADVGPLSVFVSTHLIPSDMKFNPSANPPAYVSPDENIEKGSRVRLKIVGTRTDVNEIYAIGSIKEDYLGPSPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFK4</accession>
    <name>C4YFK4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="4 7">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_01322</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="4 7"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFK4"/>
    <dbReference type="SMR" id="C4YFK4"/>
    <dbReference type="PaxDb" id="5476-C4YFK4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01322"/>
    <dbReference type="HOGENOM" id="CLU_036645_1_0_1"/>
    <dbReference type="OMA" id="VLVWTDM"/>
    <dbReference type="OrthoDB" id="425211at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000003">
        <property type="entry name" value="3-methyl-2-oxobutanoate hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001452">
        <property type="entry name" value="PRK00311.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="309" mass="34129" checksum="D56BAAA0E8575E38" modified="2010-10-05" version="1">MYRRAFVGSSRLFSTSSYFRSSYTSAARKTIADIHELYKTGESISMVTSHDFITSQILEQAKVDINLIGDSLANTTLGYDDTNELTLDEFLYHVKSVQRGNSHSLLVADMPFGSFESSIEQATTTAVKLIQKGKIQAVKIEGGNEEIIPTIKKIVSVGIPVMGHVGLTPQKHNSLGGYKLQGRSVDDSVRIFQECLNLQNAGVFAIVLECIPNKLSQYITDKLSIPTIGIGAGPYTSGQVLVISDLLGMKDGHVAKFVQQYNNFFQQGVEGVKQYTKDVKSKKFPNPDTHGYKMKKDVLDEFKEIAKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFS3</accession>
    <name>C4YFS3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_00049</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFS3"/>
    <dbReference type="SMR" id="C4YFS3"/>
    <dbReference type="PaxDb" id="5476-C4YFS3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00049"/>
    <dbReference type="HOGENOM" id="CLU_006320_4_4_1"/>
    <dbReference type="OMA" id="FIQRPTR"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001382">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="93"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="681"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="685"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="721"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ41862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="767" mass="87365" checksum="66ADF4A33F63C12B" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFX8</accession>
    <name>C4YFX8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="17">1.1.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Cytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Flavocytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">L-lactate ferricytochrome c oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">CAWG_00089</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="17"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFX8"/>
    <dbReference type="PaxDb" id="5476-C4YFX8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00089"/>
    <dbReference type="HOGENOM" id="CLU_020639_1_1_1"/>
    <dbReference type="OMA" id="RIWFRPK"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000009">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF148">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="23">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="24">
        <location>
            <begin position="170"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="71"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="123"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00078774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EEQ41902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="559" mass="62793" checksum="99F77AAF7D226A05" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGE4</accession>
    <name>C4YGE4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Centrosomin N-terminal motif 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_03120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGE4"/>
    <dbReference type="PaxDb" id="5476-C4YGE4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03120"/>
    <dbReference type="HOGENOM" id="CLU_011000_0_0_1"/>
    <dbReference type="OMA" id="EKCALEX"/>
    <dbReference type="OrthoDB" id="10255522at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="5">
        <location>
            <begin position="123"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="91"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="164"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ44826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1038" mass="122231" checksum="AB52691F34CFB5F9" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGG9</accession>
    <name>C4YGG9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-complex protein 1 subunit zeta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-zeta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_03146</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
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        <property type="protein sequence ID" value="EEQ44851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGG9"/>
    <dbReference type="PaxDb" id="5476-C4YGG9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03146"/>
    <dbReference type="HOGENOM" id="CLU_008891_3_1_1"/>
    <dbReference type="OMA" id="LHPRIMT"/>
    <dbReference type="OrthoDB" id="10052040at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
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    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
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        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
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    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02347">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="534"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ44851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="559" mass="60665" checksum="FC2E302B7E3B1A43" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGI9</accession>
    <name>C4YGI9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_03166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGI9"/>
    <dbReference type="PaxDb" id="5476-C4YGI9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03166"/>
    <dbReference type="HOGENOM" id="CLU_1825050_0_0_1"/>
    <dbReference type="OMA" id="YDNKVRF"/>
    <dbReference type="OrthoDB" id="4000888at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ44871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="143" mass="16522" checksum="DD79EEAC9842115C" modified="2009-07-28" version="1">MNLLLLFFPIYVLATIHKVELYANSTNQEINGHKISYRTGKFPSYDLYIDDQTSYYQYDDFNKVIFYDNKVRFYLTVINNILQLSPNTPLLIDIQSDGKILDDTYAVETSSIAQTSAKKNYNIWYGTDPPIDAIPLSIHASYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGQ6</accession>
    <name>C4YGQ6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LYC1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGQ6"/>
    <dbReference type="PaxDb" id="5476-C4YGQ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03238"/>
    <dbReference type="HOGENOM" id="CLU_059407_0_0_1"/>
    <dbReference type="OMA" id="NGYARIM"/>
    <dbReference type="OrthoDB" id="2020070at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055100">
        <property type="entry name" value="GNAT_LYC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053013">
        <property type="entry name" value="LAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815">
        <property type="entry name" value="LYSINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22998">
        <property type="entry name" value="GNAT_LYC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYC1 C-terminal" evidence="1">
        <location>
            <begin position="187"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="412" mass="47387" checksum="8D6A1B5EA91308E2" modified="2009-07-28" version="1">MPSTTASPDQEQLELVHLTDQELIDFTRLQNAQAWKGALSIKDYVLREQVLGKSKMATTPPNKLLIFMLRNKTDKAPLCSIELLIRKSKKYTLNKHENVVEQEDILSGCIGGVYTYPQHRGNGYARIMVDKLVVEAKELVGPSGFVFLYSEIGEYYSKNGFLSQGVDLINIPLTEGQDFATNTFDIKYDLINYHHFDLLMESYNQQNEQEIIAKVLKDGKSRITVVPSSKIIDWFHLRSKYISYKIFYEPKQNQEHIDFYNESYESIKSKLELVEPKQFGIKLYNTANEVAGFIVWTMDFNNQSVPENYVTVLKIVSFDENSKDEVAIKLLSLLKTHLIKNPILNGMNTTKIVIWESEISSHIKNVLVNQWNAQSNIDNPSRSAILMNSPIEDAKLRESEIIWEGNDKLPWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGY4</accession>
    <name>C4YGY4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_03325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGY4"/>
    <dbReference type="PaxDb" id="5476-C4YGY4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03325"/>
    <dbReference type="HOGENOM" id="CLU_130502_0_1_1"/>
    <dbReference type="OMA" id="YFQGGNN"/>
    <dbReference type="OrthoDB" id="1928736at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="12"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ45016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="107" mass="11669" checksum="C54C1045BB8CC651" modified="2009-07-28" version="1">MYAPKSNKNQENINSKLALTIKSGKYTLGYKSVVKSLRTGKAKLVIIAANTPVLRKSELEYYAMLSKTPVYYFQGGNNELGTVCGKLFRVGTLSILDAGDSDILSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH69</accession>
    <name>C4YH69_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_03411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YH69"/>
    <dbReference type="PaxDb" id="5476-C4YH69"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03411"/>
    <dbReference type="HOGENOM" id="CLU_1796201_0_0_1"/>
    <dbReference type="OMA" id="WHHYENC"/>
    <dbReference type="OrthoDB" id="10303755at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ45101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="144" mass="16163" checksum="CB5DBE0076D6E75F" modified="2009-07-28" version="1">MNLTSMCSSISIVSDYSLPTTSLSTCNPHCSFFSIIEADSQIYDGDLVIINYSCMCENAEAWHHYENCNCYDTDVKEVSSYVCNFAETALYLSGDYYETFLASNTEDEYQSVSESNEYLDRMKDSITAGSVSRTTTSKFPSSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHA2</accession>
    <name>C4YHA2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Suppressor of toxicity of sporidesmin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_03447</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YHA2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03447"/>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="OMA" id="QRMFQQY"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ABC2_TM"/>
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        <property type="entry name" value="ABC_trans_N"/>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
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    </dbReference>
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        <property type="entry name" value="ABCG_PDR_1"/>
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        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
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        <property type="entry name" value="Drug-R_PDR/CDR"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00956">
        <property type="entry name" value="3a01205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="581"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="617"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="653"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="751"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1175"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1208"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1247"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1296"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1329"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1452"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="140"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="840"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ45134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1501" mass="170271" checksum="1C6EB965943A6CE0" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHA3</accession>
    <name>C4YHA3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_03448</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHA3"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03448"/>
    <dbReference type="HOGENOM" id="CLU_019709_1_1_1"/>
    <dbReference type="OMA" id="PLTTICG"/>
    <dbReference type="OrthoDB" id="1630758at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF94">
        <property type="entry name" value="TNF RECEPTOR-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="63"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ45135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="469" mass="54494" checksum="D116EDA61B0A197E" modified="2009-07-28" version="1">MSSTKETTHEPIPDETETQDIPEYDDTTTAIVDFPTSFNFLDINDSPDIRNTKYKSPTDHLNCPICQQPFINPLTTICGHTYCKECIYECFKMAKTNNNSRTDELTGYCPLDRTPLDGANINDLFPTPLIITNLIDELKVYCANHERGCDWVGTRWELEHHVKDICQYTGVRCNGLRSDGSICQLIIERRFEDKESSKCVHLKFECEFCKTKITKITETKHLEQECLFNYKTCELCDNDMIPEKNMARHQENCRKIGRFICPAHEIGCKWIGTNETSLELHIENNCQLYHFLPTFTTMKDKMDSLVLENETLQKQINKMLDSIIQGKITNLGYSESIEEINKFESIEDQDKLVYLNFEIDRLKYEINERIIPFMNKSTVNERENMMNNLINDNFMIREDMNVQRMMINSLRKQLQFLLFSKNRNTTLSGGVGGANNMFPSMFPTEESGLGEIYETVSRSNSEERLNLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHF7</accession>
    <name>C4YHF7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_03503</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHF7"/>
    <dbReference type="SMR" id="C4YHF7"/>
    <dbReference type="PaxDb" id="5476-C4YHF7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03503"/>
    <dbReference type="HOGENOM" id="CLU_110781_4_1_1"/>
    <dbReference type="OMA" id="YPGFLFY"/>
    <dbReference type="OrthoDB" id="16510at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ45189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="108" mass="12036" checksum="DCF4D75C759391CD" modified="2010-10-05" version="1">MTVATQKFYYQPSIEANKQKLQHVHDVASLALGVGSGILTLESMNGFIFYLIGITVTNLLFYIICGEGRPSKYFKNPLQEVFISGVFSNIPGFIMMWCLVYALVKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHI1</accession>
    <name>C4YHI1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Monothiol glutaredoxin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_03527</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Heterodimer with FRA2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family. Monothiol subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHI1"/>
    <dbReference type="SMR" id="C4YHI1"/>
    <dbReference type="PaxDb" id="5476-C4YHI1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03527"/>
    <dbReference type="HOGENOM" id="CLU_026126_12_0_1"/>
    <dbReference type="OMA" id="WAEPCKT"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990229">
        <property type="term" value="C:iron-sulfur cluster assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02984">
        <property type="entry name" value="TRX_PICOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000012">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000092">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF73">
        <property type="entry name" value="GLUTAREDOXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ45213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="253" mass="28373" checksum="620E614EC32AAF2A" modified="2010-10-05" version="1">MGVIEIESEQQFTELTKADPSKLIALYFHTPWAGPCKTMNQVFKTLADSKESDNSIIFLSINADELPEISEIFEVSAVPYFILIRNQTILKELSGADPKEFIQALNQFSNNTNSTTTSNNDNVQASINSTTANTNSNNTTTNAPEVEESEEALNERLNKLTKAAPIMLFMKGSPSSPQCGFSRQLVAILREHQVRFGFFDILKDDSVRQGLKKFSDWPTFPQLYINGEFQGGLDIIKESIEDDEKFFEHALEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHY3</accession>
    <name>C4YHY3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Patatin-like phospholipase domain-containing protein</fullName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_03687</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Lipid hydrolase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PLPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHY3"/>
    <dbReference type="PaxDb" id="5476-C4YHY3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03687"/>
    <dbReference type="HOGENOM" id="CLU_009031_5_0_1"/>
    <dbReference type="OMA" id="SIVPWPH"/>
    <dbReference type="OrthoDB" id="10049244at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07229">
        <property type="entry name" value="Pat_TGL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF44">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="7">
        <location>
            <begin position="200"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="406"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="502"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="503"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ45365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="681" mass="77049" checksum="294323D12DCA7133" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHY4</accession>
    <name>C4YHY4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_03688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHY4"/>
    <dbReference type="PaxDb" id="5476-C4YHY4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03688"/>
    <dbReference type="HOGENOM" id="CLU_086730_0_0_1"/>
    <dbReference type="OMA" id="EYVYHIT"/>
    <dbReference type="OrthoDB" id="9995306at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19495">
        <property type="entry name" value="Elp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:005182">
        <property type="entry name" value="Elongator subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018627">
        <property type="entry name" value="ELP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09807">
        <property type="entry name" value="ELP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ45366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="38464" checksum="FEE8EDA6D02D7A12" modified="2009-07-28" version="1">MIQSTTTTTYTGTHIYIYIYPINSMSLNNSSQDLIFFKDNSLISDKIINQETTTTTTTTASNNFHSYLSVITYNQSTSPNWLINGLIEDTLFGNATKSLNNHESYHQMKKKDIIIKNKKIMIISFLHNKEFYIKNCKRIGINLEEKEKEQQQQQFQFIDYFNDLFINLIKNPNDSVKDINKMFDNIINSLNNDSKDDVDVIIIEGVEILLFATNITSNQLIFNINRLNKKCRQLFVVSSKECLFKNNESIGVTFSFDDPMIKINDFLIKLLHRSQLNITLEPLITGRAKDITGSLTISKGCIPYDENLSISINEKEYVYHITKDSQVKLYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI57</accession>
    <name>C4YI57_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Damage-regulated import facilitator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_03766</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DIF1/spd1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI57"/>
    <dbReference type="PaxDb" id="5476-C4YI57"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03766"/>
    <dbReference type="HOGENOM" id="CLU_132208_0_0_1"/>
    <dbReference type="OMA" id="SNVSEWG"/>
    <dbReference type="OrthoDB" id="4072855at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990846">
        <property type="term" value="F:ribonucleoside-diphosphate reductase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013900">
        <property type="entry name" value="RNR_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28081:SF1">
        <property type="entry name" value="DAMAGE-REGULATED IMPORT FACILITATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28081">
        <property type="entry name" value="DAMAGE-REGULATED IMPORT FACILITATOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08591">
        <property type="entry name" value="RNR_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ45439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="137" mass="15682" checksum="8C482ED950029D98" modified="2010-10-05" version="1">MMQPRVKRHMQNAIQPVENLNEDAASLPSVAMRIRKAVSEGYKLPGDNTASQQFSGNFQRVPLPSSMTGPPDLVNGQSTRTVSNLEEWDSYYKIQNAPLQTLPESNNYLKRKFEDDHELDLSQYQAKYGELKFNEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI98</accession>
    <name>C4YI98_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rpd3L histone deacetylase complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI98"/>
    <dbReference type="PaxDb" id="5476-C4YI98"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04170"/>
    <dbReference type="HOGENOM" id="CLU_031124_0_0_1"/>
    <dbReference type="OMA" id="DTPWANP"/>
    <dbReference type="OrthoDB" id="20886at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21964">
        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="211"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="269"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ45833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="67962" checksum="27A8703A3A952231" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIT1</accession>
    <name>C4YIT1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="5">26S proteasome regulatory subunit RPN10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_04358</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ46016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIT1"/>
    <dbReference type="PaxDb" id="5476-C4YIT1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04358"/>
    <dbReference type="HOGENOM" id="CLU_033293_1_0_1"/>
    <dbReference type="OMA" id="QMSMQDQ"/>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01452">
        <property type="entry name" value="VWA_26S_proteasome_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3990:FF:000005">
        <property type="entry name" value="26S proteasome regulatory subunit RPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="5"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="235"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ46016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="279" mass="30424" checksum="FC3F37D309CB206D" modified="2009-07-28" version="1">MVLEATMIAIDNSEYMRNGDFLTSRYEAQLTATEFIFQNKINSNPENTVGLLAYGGSGPQVLSTLTTDFGKILAGVHETKIQGENNFSSGIQVAALALKHRQNKVQQQRIIIFVGSPIKESEKELEKLAKKMKKNNVAVDIINFGEEGVNTAKLERFQSTINNHDNSHLVTISPGPRLLYEVVASSPILVEDGGFGAGVSGGDMDFFGGAGSAGDIIDPNMDPDLAMALRLSLEEEKARQEREAADRAKAEASTDLEKIDESKEDNNDKDKDVNMEDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIY4</accession>
    <name>C4YIY4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1279 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIY4"/>
    <dbReference type="PaxDb" id="5476-C4YIY4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03796"/>
    <dbReference type="HOGENOM" id="CLU_059211_2_0_1"/>
    <dbReference type="OMA" id="VHSMGQE"/>
    <dbReference type="OrthoDB" id="426386at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045866">
        <property type="entry name" value="FAM210A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009688">
        <property type="entry name" value="FAM210A/B-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377:SF0">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06916">
        <property type="entry name" value="FAM210A-B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1279" evidence="1">
        <location>
            <begin position="33"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="212" mass="23771" checksum="11293924E874E4FC" modified="2010-10-05" version="1">MFSFKGFGSAIRPLRFVNHGMFRFQSTRAAKPQGIKALMKEYGYPALAVYLGLSCIDLPICYVLVHSMGQEKIEVYENKVKQTFGYGISDEELKKKQEINKIQQDIESQGETTSENSGSMVSYILSQFSWTEFAIAYGIHKSLIFIRLPITAAITPGIVKLLRGWGFRIGTDKLSTTASIAKDLAKSGIKDITASSAKFGVKPGNKKWWWFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ65</accession>
    <name>C4YJ65_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ65"/>
    <dbReference type="PaxDb" id="5476-C4YJ65"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03878"/>
    <dbReference type="HOGENOM" id="CLU_2145507_0_0_1"/>
    <dbReference type="OMA" id="IRTEHSH"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="112" mass="13474" checksum="5C9A3ADA054A8C02" modified="2010-10-05" version="1">MQVSKSYARPHLSNYKASRVNLVKNKRNYYAFHADTDLRQRNFIRTEHSHRSHTIEAFFFLNCAFFSIEQELRKRQTIKFNYFVHLVTKLVLFFFVMARVNPKSLFITTPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ69</accession>
    <name>C4YJ69_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L16, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_03882</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ69"/>
    <dbReference type="SMR" id="C4YJ69"/>
    <dbReference type="PaxDb" id="5476-C4YJ69"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03882"/>
    <dbReference type="HOGENOM" id="CLU_078858_0_1_1"/>
    <dbReference type="OMA" id="MPGMYEF"/>
    <dbReference type="OrthoDB" id="268521at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000010">
        <property type="entry name" value="60S ribosomal protein L16, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_uL16_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_uL16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220:SF13">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ45553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="213" mass="24272" checksum="67AC47BD413D95F2" modified="2010-10-05" version="1">MFNQFKSTSVFNSIFGSFRRFKHEYAPRFKEVEKAQKGRVSVRTGGSIKGNSLEFGKIGLRLKSQGIRMHANQLQAADKVLRRELRPTKSKLYTRFVCDLAVCIKGNQTRMGKGKGAFDHWASRMPTGKVLFEIDGPIHDKVARDALRKAADKLPGLYEIITPESKVRVSLTHLIDKPEPVDYVEKLNAKPTKKWANVQAYHTDPMYKQYSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJE2</accession>
    <name>C4YJE2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_03955</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJE2"/>
    <dbReference type="PaxDb" id="5476-C4YJE2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03955"/>
    <dbReference type="HOGENOM" id="CLU_608318_0_0_1"/>
    <dbReference type="OMA" id="MINTYDY"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF6">
        <property type="entry name" value="PROLINE UTILIZATION TRANS-ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="328"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ45626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="453" mass="52382" checksum="D4B2E1917D7C619C" modified="2009-07-28" version="1">MVEANFLKYFYYQACCNRSNSWINLGSAIRLAQALGMHRKIINDKIENQEISIHRRRLWRSLYVCDCVSSVNLGRPLMINTYDYDDINYPVEKLLLDENDNVERIRIIAQNATSDSAVLNRSIVQNLYNGGSINIKDSNSLALQLKLWSIELPNFLQLTSDMENQLRDPTNPNNYLFVFVHIGQLYGIMALTRPFLVHVVNRKLRPNMYKPQVTDEKQLMPFCKASIKAAFLTIKLFKFYCTFNKSRKEVFTIQSATFFASILLGFTLLEQINSKKPDHHYISVIKESIRDAISIFKLFNFNATCNRWAQHLIYMMEALNRPPAIIPSSLQQTTKTSTTTTTTPVLSTHPITSTNLNYQQQQQQQQQQVPPPPPGSGNVKFPFQNKNNSSPSASSISSEIDRFNDELIRWNNDNTAFEQMVNFQQYFVPNDIDVLNNNYLDAFNYTNTYKYNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJE5</accession>
    <name>C4YJE5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJE5"/>
    <dbReference type="PaxDb" id="5476-C4YJE5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03958"/>
    <dbReference type="HOGENOM" id="CLU_041801_0_0_1"/>
    <dbReference type="OMA" id="SINDINW"/>
    <dbReference type="OrthoDB" id="5378975at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031355">
        <property type="entry name" value="YBL010C/LAA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17104">
        <property type="entry name" value="YBL010C_LAA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="500" mass="56548" checksum="2FABB3E7AFE9029B" modified="2009-07-28" version="1">MTSNNDDNVNLEKLNISDEIINDYDNGSQEQLDVLEAYQTDEDKQEQEQKEKEKDVELDNPDLEEEVGITMNDDEGDHKLNNQKIDDEINKEDEKDVKASDDDHDDDDDDDFDDFNEASFQQAPTIGSTNQENGHDGNDDDDDEFGDFDDFQVSQPSPTQQQQQKQQSQTQSQSISIDKVNFPTTIFNSPKEFSQRLTTTLDEIFPTSTPILEDNNNKNQITTSIQLLNERSQEIYKQLSTLPYLQPTNWIKSNIRHNLLIKLGIPINLDELNDTNTISANPNNKNIVTSETQNDLKIPGYNFGSGGGSGGGFVSVSGRQRKSSISINDINWNELNLISEIPKFESLNIDDNLKNSLINSTLDKLNQFELDNLYHNSTTTTTTTTISVTTTTAEGDGSNNNNNNKSNSSSNDSGSTIGGGHANSQWIDEKLNKLTSNYNELLTLSSIWINQIDQLHEEFEIYENVIQSFIGYNQKLRREEIFENLKKLKKKKKKGKATKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK43</accession>
    <name>C4YK43_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sedoheptulose 1,7-bisphosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK43"/>
    <dbReference type="SMR" id="C4YK43"/>
    <dbReference type="PaxDb" id="5476-C4YK43"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05838"/>
    <dbReference type="HOGENOM" id="CLU_033323_13_0_1"/>
    <dbReference type="OMA" id="GWLIWRD"/>
    <dbReference type="OrthoDB" id="4818801at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050278">
        <property type="term" value="F:sedoheptulose-bisphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046390">
        <property type="term" value="P:ribose phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000022">
        <property type="entry name" value="Phosphoglycerate mutase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF15">
        <property type="entry name" value="SEDOHEPTULOSE 1,7-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="102"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ47272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="27175" checksum="B5A3A1C3803719D5" modified="2009-07-28" version="1">MTKSPCPRLIFVRHGQTEWSKSGQYTSRTDLDLTPFGVKQMRNTGKGLIGPGNLQMIKPENLTHIFVSPRKRAQRTSQLLLEEVDPEIKDKIPIEIDEDVREWEYGEYEGLKTNEIIELRKQKGLDKDSEWTIWGKGCEGGEQHYEVAARLDRFIEKIQKIHREALAKGVASDIIVVAHGHILRCLVARWVKRELSTNPQLILDAGGVGVLSYQHHNVDEPAIYLAGAFTVPVEEEGADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK75</accession>
    <name>C4YK75_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_05872</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK75"/>
    <dbReference type="PaxDb" id="5476-C4YK75"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05872"/>
    <dbReference type="HOGENOM" id="CLU_032828_4_1_1"/>
    <dbReference type="OMA" id="PIASCYV"/>
    <dbReference type="OrthoDB" id="306876at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="6">
        <location>
            <begin position="12"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="6">
        <location>
            <begin position="186"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ47304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="368" mass="40982" checksum="65A567C26DB03DB4" modified="2009-07-28" version="1">MSVYSKYIKPNIGLSLLLLSQFLNSIMVTTCKLLVTDKNFNTPIHPAQILFVRMFITYICCLLYMAITRSVPDAPFGPKPIRKLLLLRGLVGFFGVFGMYFSLQYLSLSDAVALTFLVPMVTAFLAFVLLHEKYSILEAICSVFSLAGVVLIAKPTFIFGNESNKETGNDETIESSSSEKRILATIVGLIGVCGASSVYIVLRKIGMNAHPLLSVSYFALTCCIVTFLAILVIPSLTFVLPTNAYQWTLFFIIGFSGFFMQFSLTAGVQRVKAARASLMAYSGMIFAVVWDLTIWHHFPGILSFLGITLIIGNAIIILKFKPQQEEITDKQGDDIERNGKYNRVDDSITMQDFIITDDEEEENVRGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK79</accession>
    <name>C4YK79_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-type lectin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_05876</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK79"/>
    <dbReference type="PaxDb" id="5476-C4YK79"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05876"/>
    <dbReference type="HOGENOM" id="CLU_041093_2_0_1"/>
    <dbReference type="OMA" id="YKNGKRG"/>
    <dbReference type="OrthoDB" id="270293at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07308">
        <property type="entry name" value="lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF45">
        <property type="entry name" value="RE50040P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ47308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="322" mass="37412" checksum="EBB377284CA8C647" modified="2009-07-28" version="1">MFSKWPIHAESFEMELTFHIHNPDVKHGLVGDGLAIWFLDKPSDIGDVFGIQNKFNGLGIMLDTFKNGKRGQFPYVNLMLGDGNAMYNKATDGYETRLAGCIAKQLLNPEAKETKMRLVYIKSGYLSIDFNYYGHHEQWQNCVTLTDVKLPETKYLGLSAETGQLVENVDIIENRIYALYKPDDTFVESIDELQELIREQNEYDSEVSSVASIVKEEAKAKEKKRGGGRHRAFKKKLSSERRKSLKRLEMAEKRIKEQERQYRLKKYGHEDINFITYWFGKFLVLVKYILYLLIAVVIVWFALIVFRIQKQKRKSKTTGLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKA1</accession>
    <name>C4YKA1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_05898</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKA1"/>
    <dbReference type="SMR" id="C4YKA1"/>
    <dbReference type="PaxDb" id="5476-C4YKA1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05898"/>
    <dbReference type="HOGENOM" id="CLU_015166_3_1_1"/>
    <dbReference type="OMA" id="WRPMRGM"/>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048250">
        <property type="term" value="P:iron import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000245">
        <property type="entry name" value="Mitochondrial RNA-splicing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF4">
        <property type="entry name" value="MITOFERRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="24"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="130"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="227"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ47330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="325" mass="35369" checksum="5259CBF46C7D0DF9" modified="2010-10-05" version="1">MEHQLQFLPKDSVEIDYEALPDDASLAAHLTAGALAGIMEHTVMFPIDSIKTRMQMNLSNSEISRGLLKSLSKISSTEGFYALWKGVSSVVLGAGPAHAIYFSVFESTKTFLVNRLTNSPHSNRIVTDENHPLIASCAGITGTTASDALMTPFDMLKQRMQANAAYQDGKSTSVRLFKLASDIYKAEGLSAFYISYPTTLLTNIPFAALNFGFYEYSSSLLNPSHVYNPYLHCVSGGIAGGIAAALTTPFDCIKTVLQTKGISQNQNFRHVTGFKSAAVALLKQEGAKAFWKGLKPRVIFNIPSTAISWTAYEMCKEVLIRGKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKI6</accession>
    <name>C4YKI6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_05990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKI6"/>
    <dbReference type="PaxDb" id="5476-C4YKI6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05990"/>
    <dbReference type="HOGENOM" id="CLU_053359_3_0_1"/>
    <dbReference type="OMA" id="KWRIFTH"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF2">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="7">
        <location>
            <begin position="48"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ47415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="170" mass="19446" checksum="7C311FE33DD4BE93" modified="2009-07-28" version="1">MNKQTNLNDNKEVEGVEGEIPNKWRIFTHCSKLFQFQIVLKNRGSVARDHMANERTFLSWIRTALVFLTFSIGFLQFYRLEIKANTNTLGDSNLSQMIQTLGKPLGAMGTILSGLTVTFGTIRYFQVQELLLDDYYPVTRFTIIILILINLSILVVSFILNIDISLFVMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKW8</accession>
    <name>C4YKW8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_06127</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKW8"/>
    <dbReference type="PaxDb" id="5476-C4YKW8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06127"/>
    <dbReference type="HOGENOM" id="CLU_027584_0_0_1"/>
    <dbReference type="OMA" id="APRVCIS"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000069">
        <property type="entry name" value="Transcriptional regulatory protein ASH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="3">
        <location>
            <begin position="361"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ47547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="451" mass="50628" checksum="5CDB4C427EA10847" modified="2009-07-28" version="1">MSLVQSAMFNHHMGPSHTRSRSFELFQEAKTLRVAACKRSYSDDLNISTKRARTAPPSPPYETATPTRASRLVISNLVKPTSNLRSRSLSPNKKFSSPLSPSSSPIATVTSPISSPQNIKIKLPSISDALNLPPITSKEPVKLKPIVPTVSLDYFDTYKPNDENWRYGLLDKIAKESKHFHLNQYNYLNDHAKPSFDSKLSSKIQQSSIANGKKINFPYESNYTYLNKTYLNDVKNYPEYLELAAESLLQLKERQLPPPPLQSHQKQHPPPPPPHLPVQGLLPVPAPAVSHFSSYTTPQAPAFYHPPSQQQQQQQTPPPQTLHHQQPQPPISTHKFIPISPPSAKKSRSDLLKSPPKHHHHHAPRVCISCGSDQSPCWRPSWSIKQGQLCNSCGLRYKKTKARCLNDKCKKIPAKGEWTLMQSKGKETFEDGIEGYSCIACGWRVEVLPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLG9</accession>
    <name>C4YLG9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_01687</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLG9"/>
    <dbReference type="SMR" id="C4YLG9"/>
    <dbReference type="PaxDb" id="5476-C4YLG9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01687"/>
    <dbReference type="HOGENOM" id="CLU_015246_1_0_1"/>
    <dbReference type="OMA" id="FYQGPPF"/>
    <dbReference type="OrthoDB" id="2306at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000102">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001419">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856">
        <property type="entry name" value="WD-REPEATCONTAINING PROTEIN WDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="194"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="237"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="322"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="530"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ43450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="613" mass="67330" checksum="8AEBF76872455E97" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-10-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLK8</accession>
    <accession>P46599</accession>
    <accession>P78596</accession>
    <name>STE7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>Serine/threonine-protein kinase STE7 homolog</fullName>
            <ecNumber>2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">HST7</name>
        <name type="synonym">STE7</name>
        <name type="ORF">CAWG_01727</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1995" name="Mol. Gen. Genet." volume="249" first="609" last="621">
            <title>Constitutive activation of the Saccharomyces cerevisiae mating response pathway by a MAP kinase kinase from Candida albicans.</title>
            <authorList>
                <person name="Clark K.L."/>
                <person name="Feldmann P.J."/>
                <person name="Dignard D."/>
                <person name="Larocque R."/>
                <person name="Brown A.J."/>
                <person name="Lee M.G."/>
                <person name="Thomas D.Y."/>
                <person name="Whiteway M."/>
            </authorList>
            <dbReference type="PubMed" id="8544826"/>
            <dbReference type="DOI" id="10.1007/BF00418030"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2"/>
    <dbReference type="EMBL" id="L19195">
        <property type="protein sequence ID" value="AAB59338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S60154">
        <property type="entry name" value="S60154"/>
    </dbReference>
    <dbReference type="PIR" id="S60159">
        <property type="entry name" value="S60159"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLK8"/>
    <dbReference type="SMR" id="C4YLK8"/>
    <dbReference type="PaxDb" id="5476-C4YLK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01727"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="OMA" id="SWAKKIR"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="PHI-base" id="PHI:462"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06620">
        <property type="entry name" value="PKc_Byr1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001756">
        <property type="entry name" value="Serine/threonine-protein kinase STE7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001022">
        <property type="entry name" value="Serine/threonine-protein kinase STE7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049613">
        <property type="entry name" value="Byr1-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000413043" description="Serine/threonine-protein kinase STE7 homolog">
        <location>
            <begin position="1"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="249"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="185"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="473"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="255"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine" evidence="1">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAB59338." evidence="5" ref="1">
        <original>Q</original>
        <variation>T</variation>
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAB59338." evidence="5" ref="1">
        <original>A</original>
        <variation>S</variation>
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="589" mass="65218" checksum="D334AA13E13DA686" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM32</accession>
    <name>C4YM32_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidant-induced cell-cycle arrest protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_01907</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OCA5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM32"/>
    <dbReference type="PaxDb" id="5476-C4YM32"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01907"/>
    <dbReference type="HOGENOM" id="CLU_042943_0_0_1"/>
    <dbReference type="OMA" id="WIIRYLR"/>
    <dbReference type="OrthoDB" id="27140at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF27">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="53"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="443"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ43663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="502" mass="57846" checksum="7784AC3E2EEDDAEA" modified="2009-07-28" version="1">MLKENEIISRALVTIDNFKGSLKAFKSSITDGGYTQLHMPNCFSRTLVWKVCLITDSLKISTWESKLNDSRVVFDQLISRDDMKLPWNKLDSDSVFYHSGDLSRKSSITRKSSSRDSKGLHKVSLLRVNTTEDPLSSSAQLSGYVNTGDDLELLQTIILDIDRLFPGEDFFSESNKYSIYRKKQLIEILYLWSKCNPQVGYKQGLHEILGLIYMNLSQESVDISQTNTFSSDDMKILSLYNVHYLCHDVFTIFNKFMLQSGNITHFYASEDALWKSIENFNVYLMKIDQFIHYTLNTKLNLEPQLWIIRYLRLLLLRELGSDLETTMLLWDKLVSLQLPINSGNSISSIPDILNFMIIQLLIQVKTDILSSDFSECLSILLHYPFKPTTQIEKHEFVKKLFKDAVKLYEKRNDDLKLYEYGIRLNNRYNPNLKILMNYTNGERSSTESVNSSRAASPAPGSNPPPTSAPPSLSSSRNDNMKFEKMRLEMRLKKKAQSMINPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM58</accession>
    <name>C4YM58_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_01934</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM58"/>
    <dbReference type="PaxDb" id="5476-C4YM58"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01934"/>
    <dbReference type="HOGENOM" id="CLU_013430_10_0_1"/>
    <dbReference type="OMA" id="KKPIREY"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000012">
        <property type="entry name" value="Cation diffusion facilitator 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF4">
        <property type="entry name" value="CDF DIVALENT METAL CATION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="324"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="257"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ43689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="616" mass="68793" checksum="3D55FA37715322CC" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMD9</accession>
    <name>C4YMD9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_02018</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMD9"/>
    <dbReference type="PaxDb" id="5476-C4YMD9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02018"/>
    <dbReference type="HOGENOM" id="CLU_024840_0_0_1"/>
    <dbReference type="OMA" id="YYHPQRN"/>
    <dbReference type="OrthoDB" id="5595109at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12710:FF:000008">
        <property type="entry name" value="Protein arginine methyltransferase NDUFAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ43770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="527" mass="60452" checksum="D81E33EC4376C140" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C4YML6</accession>
    <name>C4YML6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_02099</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YML6"/>
    <dbReference type="PaxDb" id="5476-C4YML6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02099"/>
    <dbReference type="HOGENOM" id="CLU_001645_9_12_1"/>
    <dbReference type="OMA" id="WSIDKAP"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18533">
        <property type="entry name" value="PTP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000115">
        <property type="entry name" value="Tyrosine-protein phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016277">
        <property type="entry name" value="Ptp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000938">
        <property type="entry name" value="PTPN1_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="63"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="9">
        <location>
            <begin position="270"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ43847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="371" mass="42665" checksum="4F4436600E1D0D0F" modified="2009-07-28" version="1">MFQFIPFPISFTKMNIFKKPITAVTTGLTAITSNESRKENSDSSSSSSKKSTPAVLTISSHKQREDFNELNEIESQRIVEGLNNAATSIWSISAGISRVNRKRNRYTNVTPWDRTRVKLPVVDGSFSDYINASHIHLKTTASKISNRYIACQGPLEHTTHHFWAMCFNESEKQKNDVIVVVMVTPLVENGMVKCDRYWPELHETWDFTSKNAEDGIKYEKLTLTNIGENHKESEDYLITELELKSPTKSKKVYHYYYYKWADAKVPPSIEPLIALSRSVYKINQPLIESGKPLVPIVHCSAGVGRSGTFMAFDHLFRDADKFRNLVHEDRIASKDLVYQSVCQLRNQRMMTVQTVYQYCFLYEAARTIYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMN1</accession>
    <name>C4YMN1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMN1"/>
    <dbReference type="PaxDb" id="5476-C4YMN1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02114"/>
    <dbReference type="HOGENOM" id="CLU_2305674_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946631" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10913" checksum="967719C08D680E68" modified="2009-07-28" version="1">MVLCGFFFLFSMEPSSDFQQNSEPTRVTLVRAFFFLLPSVRESQTLYVCSVNPPPLPPRPIPSDIKPLHHHPSLNPQVFFISLFFFFFSTSIHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMV0</accession>
    <name>C4YMV0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Meiotic sister chromatid recombination protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMV0"/>
    <dbReference type="PaxDb" id="5476-C4YMV0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02187"/>
    <dbReference type="HOGENOM" id="CLU_009916_0_0_1"/>
    <dbReference type="OMA" id="REWLYLH"/>
    <dbReference type="OrthoDB" id="2527403at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018803">
        <property type="entry name" value="Ish1/Msc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10281">
        <property type="entry name" value="Ish1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005668031" description="Meiotic sister chromatid recombination protein 1" evidence="2">
        <location>
            <begin position="19"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="605"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ43931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="788" mass="91623" checksum="F355B35BD7B07232" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMZ1</accession>
    <name>C4YMZ1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRELI/MSF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMZ1"/>
    <dbReference type="SMR" id="C4YMZ1"/>
    <dbReference type="PaxDb" id="5476-C4YMZ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02228"/>
    <dbReference type="HOGENOM" id="CLU_067902_3_1_1"/>
    <dbReference type="OMA" id="GYEFFKC"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="196" mass="23057" checksum="7466A526F5D32A20" modified="2010-10-05" version="1">MVLYFENKHQFKFDFETTSLAYFNRYPNPYAKHVLSIDTIESYIDNQGQLCTTRLIVKTGRLPNFIKPILGNSLNSWIIEKTIINRHDKTLISYTSNLDHRKFIRVEEYLKYSGHQEDNDNGDGRGLTNLESKVKFSSNLFGFKQKIEQWSHQKFSTNIKNSREGLQYVMMKLKQRSNGLLLQERKLKPKPPSQCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN33</accession>
    <name>C4YN33_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Required for respiratory growth protein 7, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_02273</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRG7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN33"/>
    <dbReference type="PaxDb" id="5476-C4YN33"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02273"/>
    <dbReference type="HOGENOM" id="CLU_085105_0_0_1"/>
    <dbReference type="OMA" id="YYENEYA"/>
    <dbReference type="OrthoDB" id="20734at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018828">
        <property type="entry name" value="RRG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133:SF1">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10356">
        <property type="entry name" value="RRG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ44014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="273" mass="31320" checksum="8C36F407062B06D7" modified="2010-10-05" version="1">MISILRQPIYIILNNSLSTTSLRGLKFSAIQDCQQYLSYCSKNSINTGSTVFRGTLYELHVKAFFEKYLNCENLIKNGGAYDNGVDIIGKWNLSPFYNEQEREYEYDTKPIKLSSKSILKYSQESKFNIASNPISLINDIQVLIQCKNVKKKPDAKIIRELSGILDFHKFNKKSTFMFIVTPYPCTPQAVVQLDTTNHAIIHFMISPLTNNSVKITRNQDNDDNDNDYSGDSFFNLDSWKGGDLKLVYMNRQARKLLSGLNMEQKLKLISFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN59</accession>
    <name>C4YN59_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-terminal acetyltransferase complex ARD1 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_02299</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN59"/>
    <dbReference type="SMR" id="C4YN59"/>
    <dbReference type="PaxDb" id="5476-C4YN59"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02299"/>
    <dbReference type="HOGENOM" id="CLU_013985_7_2_1"/>
    <dbReference type="OMA" id="MSMQNAN"/>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="3"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ44040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="210" mass="24049" checksum="EDBAFAA1DA0136A6" modified="2010-10-05" version="1">MGITIRQATIEDIQAMQNANLHNLPENYQLKYYMYHILSWPQASFVATTYDEVINVNDGEIDVPVTQDPKGDTAYINRGEKIVGYVLGKMEDDPEAADKTPHGHITSLSVMRTYRRMGIAEKLMRQSLYAMCESFGAQYVSLHVRKSNRAALHLYRDSLKFEVQSIEKSYYQDGEDAYAMRLDLKLEELLPSLAQKAEESDDLIKDLLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNB2</accession>
    <name>C4YNB2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Formin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_01368</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the formin homology family. BNI1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YNB2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01368"/>
    <dbReference type="HOGENOM" id="CLU_002339_0_0_1"/>
    <dbReference type="OMA" id="PWLNAFE"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000142">
        <property type="term" value="C:cellular bud neck contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001411">
        <property type="term" value="C:hyphal tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000920">
        <property type="term" value="P:septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.2220:FF:000006">
        <property type="entry name" value="Cytokinesis protein sepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001452">
        <property type="entry name" value="Formin, involved in spindle orientation, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="9">
        <location>
            <begin position="110"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="10">
        <location>
            <begin position="965"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="746"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1459"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="660"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ43145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1497" mass="169860" checksum="8A90BEEFA0AC561E" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNF7</accession>
    <name>C4YNF7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ran-specific GTPase-activating protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_01417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNF7"/>
    <dbReference type="SMR" id="C4YNF7"/>
    <dbReference type="PaxDb" id="5476-C4YNF7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01417"/>
    <dbReference type="HOGENOM" id="CLU_067861_0_1_1"/>
    <dbReference type="OMA" id="NFKDSFM"/>
    <dbReference type="OrthoDB" id="2357150at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13179">
        <property type="entry name" value="RanBD_RanBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000591">
        <property type="entry name" value="Ran-specific GTPase-activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045256">
        <property type="entry name" value="RanBP1_RanBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="74"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ43190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="212" mass="24192" checksum="438A9E2CC5C9084A" modified="2010-10-05" version="1">MSAEDTKPKTEESSSIPKPPTSNVFSMFGAKKEKKPEQEDSDNKKESDKKEEKDTSKSTGDDNEVAEEEEADVEFTPVVQLDKKVDVKTNEEDEEVLYKVRAKLFRFHGDSKEWKERGTGDVKFLKHKTTGKVRILMRRDKTLKICANHLISADYELKPNIGSDRSWVYTVTADVSEGEPEAQTLAIRFGNKENADLFKEHFDNAKKEAKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNG5</accession>
    <name>C4YNG5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_01425</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNG5"/>
    <dbReference type="MEROPS" id="S08.A50"/>
    <dbReference type="PaxDb" id="5476-C4YNG5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01425"/>
    <dbReference type="HOGENOM" id="CLU_011263_1_0_1"/>
    <dbReference type="OMA" id="YWASPAS"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF13">
        <property type="entry name" value="SUBTILASE-TYPE PROTEINASE RRT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="7">
        <location>
            <begin position="159"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="421" mass="46605" checksum="D6D371948D1792A1" modified="2009-07-28" version="1">MYWVPIERGFLIIRKEGANPVLIELMEMLINLACVFIALIDKCFSNDSYFVSLKASESIDHFMEYDKRYPKHLQVRDFISNSIAIGDFKGFSGRFSKDIIDRLKRCPLVQEITEDIMFNALDFEIQEDAPRHLARISRRRRMKPNKPYPYMYETEYSGQGVNAYVIDSGIEVDHPEFEGRASAGYDFTEEGSGDNNGHGTHVAGLIGSVTYGVAKNVRIVEVKALNSKGAGSLSTILAAIDFAVNHRIESGRKGVANLSLGAYKNHILNKAIEQATNTGLVFVVAAGNSNINACMTSPASSKYAITVGAIDDYTDSVTAFSNWGECVDIFASGAYVRSVDARNHDKTQVLSGTSMASPIVTGMVANLLSQNVESGKIKSVLIRMAAKNKITKTSLFLRKKTPNRILYNGIQEREIEYNEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNG9</accession>
    <name>C4YNG9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_01429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EEQ43202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="461" mass="54331" checksum="8019CEA956FE3A94" modified="2009-07-28" version="1">MANKISTIRYKRQIRPLLSKIHTLNDLYSKNPSLFEFDISKIDINKPIKSPDADYHPRKRTKTVLLEESLEPDFYNPRTPEERLKSLKHYVSSELFKAYTELLSILKPVLISLAPSDCSWTLATRCAFEIGKEMAESTTTTYYRLNNVHLFDPDLVNPSIKELYDELYGDIDDWIDMEPAQVTNNYRQYLLIGYVSKLLVIHSQTTLYIFLPVLLHWLSHQNPYLRHLGQLLANDFFSFPDNSTTNIEELNGLKFNNTSRIFWTLYGVDYWKPFLNRASLSVVLPYKISLELFDELEGTHQLPKGYYRRELYSMFQICLNYNIIVMIMVKILQKTRKKCKTYEDAYQHFKNIYTLAVEMACNWLPFYSITFPNNKIIFNSLRQLQEFMQGKLKVLSSQGGKYTLLYKRSQGFFESLEAISYYYLYPDRKIILNSVDTVAKTAVKLRIDNHKFLAWLNRNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNM5</accession>
    <name>C4YNM5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinetochore-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_01488</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <location evidence="1 9">Centromere</location>
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        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <text evidence="9">Associated with the kinetochore.</text>
    </comment>
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        <property type="protein sequence ID" value="EEQ43258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YNM5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01488"/>
    <dbReference type="HOGENOM" id="CLU_117280_0_0_1"/>
    <dbReference type="OMA" id="SSCFPEY"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
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        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016851">
        <property type="entry name" value="Nnf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007128">
        <property type="entry name" value="PMF1/Nnf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459:SF3">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03980">
        <property type="entry name" value="Nnf1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nnf1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 9" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 9" id="KW-0158">Chromosome</keyword>
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    <keyword evidence="5 9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="135"/>
            <end position="187"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR027153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ43258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="196" mass="22211" checksum="AF500BCFB36A0674" modified="2009-07-28" version="1">MSADENNKVRFERLRLVARKALEQSIKKSLTMEQVKTCFPTLVTSQDGVRSLELALSQMSGFWHANSLDEFDLIYKEKDIESKLDELDDIIQNAQRAKDSGKEPSNIDQLSPLEIVDSTIVSNSKNVLDSLQMIYDQLCLDNAELYTELSELTKESTRINNSIKSGIEQLNKEANSVELEKAGLQIDKLIDILEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNS3</accession>
    <name>C4YNS3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_02856</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNS3"/>
    <dbReference type="PaxDb" id="5476-C4YNS3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02856"/>
    <dbReference type="HOGENOM" id="CLU_012923_4_3_1"/>
    <dbReference type="OMA" id="CLAIFWK"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="551"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="568"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ44582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="593" mass="68020" checksum="A94F73AA2531C663" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNS6</accession>
    <name>C4YNS6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_02859</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNS6"/>
    <dbReference type="PaxDb" id="5476-C4YNS6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02859"/>
    <dbReference type="HOGENOM" id="CLU_009646_3_2_1"/>
    <dbReference type="OMA" id="YNPQVKW"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF666">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="587"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="667"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="691"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="735"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="318"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="253"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="625"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="28"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ44585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="762" mass="84782" checksum="CCEA01856EDE690B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPA7</accession>
    <name>C4YPA7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Pre-mRNA-processing factor 19</fullName>
            <ecNumber evidence="14">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_03057</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the WD repeat PRP19 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="14"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPA7"/>
    <dbReference type="SMR" id="C4YPA7"/>
    <dbReference type="PaxDb" id="5476-C4YPA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03057"/>
    <dbReference type="HOGENOM" id="CLU_023894_0_1_1"/>
    <dbReference type="OMA" id="DICEHRS"/>
    <dbReference type="OrthoDB" id="687049at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16656">
        <property type="entry name" value="RING-Ubox_PRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000027">
        <property type="entry name" value="Pre-mRNA-processing factor 19, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038959">
        <property type="entry name" value="Prp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013915">
        <property type="entry name" value="Prp19_cc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055340">
        <property type="entry name" value="RING-Ubox_PRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08606">
        <property type="entry name" value="Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 14" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="13 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 14" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="U-box" evidence="16">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="136"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ44766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="446" mass="49269" checksum="DF88A54F118EA5A8" modified="2010-10-05" version="1">MICSISGEIATDPVVSPKSGAIFQRKHIVNYIATSGTDPITDEPLTESELISLKVNEKSTAIAQPSPPDPSNSSIPSLLSTFQNEWDAIVLEVFTLKKQLQSAKQELSIALYRQDAAVNVAAKAIRERDEAREALEKLSSSINLSDVPDTNTPPEEAEPKPKKSKKSSSKGTSAKHSNDKDSETIDSEQIENIVRARDELFRLHKSQKIKLPFDVDTFLKQKGVDIQSIFEGEKISNYVYNKEIDTIVGVSQDKVIKHSLVDGASTKLDLKNVKLVEINNNGVVAVSSGTKIMFSNYKTIELNCEAEQIICHPSLDFFVVLAAKKWFVISTDSIVASRNGVLSLGALHYDGEILATKNDDKIKLYSIVSGDELGTFTATHENIAKLEFATNGYWLLALSTGDNTSSIQIFDLRKGIEVQNLQFNEVATKKIGNIMFYSLHSFFKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPD8</accession>
    <name>C4YPD8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable transporter MCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_03091</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPD8"/>
    <dbReference type="PaxDb" id="5476-C4YPD8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03091"/>
    <dbReference type="HOGENOM" id="CLU_012596_3_0_1"/>
    <dbReference type="OMA" id="PTMWWLA"/>
    <dbReference type="OrthoDB" id="199930at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17354">
        <property type="entry name" value="MFS_Mch1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF45">
        <property type="entry name" value="TRANSPORTER MCH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ44797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="436" mass="47901" checksum="0B82C892EF2C1446" modified="2009-07-28" version="1">MHKHLHHVSHTIKSYLSTHIALENLKVVAFLISLLSCLVAGSILLFTLYTSSFHEVLGLSYLQINMISSLSALGMYFCLPVLGYLADSYGPALLSLFSIWFFCPSYFVNSYLVSTQSGSVIGFCVCFCFIGLATSSLYFSSLITCARIYPDHKGLAISLPITCYGLSALLGAQILKLPYFHRHEVLDLEVVFSFFAWLYLVVGIASFVSSSIVIVESELLFGVTPDEETALLELTPTRSLEPPNHRQRFVSFVKDPSAWILLVSLILNIGPMESYQNNLSSILKHTNGADLPNQVSIMAASSTGARLLLGVLSDYSSKYVCRVWLLVVVIVVGVAGQMSETSATLNGVSYGGMFTIYPTIVASIWGIDIMGSTWGSFMVAPALGSVIFSMFYGRNADSCSDCLSHYFYTTAGAMIVSCIFVLLAWKIWYARGFTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPF7</accession>
    <name>C4YPF7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peroxisomal membrane protein PMP22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_02356</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPF7"/>
    <dbReference type="PaxDb" id="5476-C4YPF7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02356"/>
    <dbReference type="HOGENOM" id="CLU_066033_2_0_1"/>
    <dbReference type="OMA" id="CLGTFFN"/>
    <dbReference type="OrthoDB" id="860at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF93">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN 25D9-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ44096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23337" checksum="04E142875008F3AA" modified="2009-07-28" version="1">MSSLNAQYLAYLIKYPLLTKSITSGVFSGLNETVASVLTNEFQETKVAGIKIKHVFTQKLLTMIIYGSCIATPISHYMYFIINNKIFKGPLTKSGKILQILTSLSTVTPTLAACFVSWIALINNYKLPKGSISPIAELNKIVAIVRAGLKKGYFGVLKSSLVTSSVALVIAQKFVPPELWVVFFNVVYFFLGTYQNTKLKRLQKQQRLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPZ0</accession>
    <name>C4YPZ0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Vacuolar aminopeptidase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_02544</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPZ0"/>
    <dbReference type="MEROPS" id="M18.001"/>
    <dbReference type="PaxDb" id="5476-C4YPZ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02544"/>
    <dbReference type="HOGENOM" id="CLU_019532_3_0_1"/>
    <dbReference type="OMA" id="DWPIAKI"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF4">
        <property type="entry name" value="VACUOLAR AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ44279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="517" mass="56734" checksum="F39FDB1EC7DB9227" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ21</accession>
    <name>C4YQ21_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">candidapepsin</fullName>
            <ecNumber evidence="4">3.4.23.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_02575</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 of insulin B chain. Activates trypsinogen, and degrades keratin.</text>
            <dbReference type="EC" id="3.4.23.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.24" evidence="4"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ21"/>
    <dbReference type="SMR" id="C4YQ21"/>
    <dbReference type="MEROPS" id="A01.066"/>
    <dbReference type="PaxDb" id="5476-C4YQ21"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02575"/>
    <dbReference type="HOGENOM" id="CLU_013253_9_1_1"/>
    <dbReference type="OMA" id="TSGETWI"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000011">
        <property type="entry name" value="Aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000023">
        <property type="entry name" value="Aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946704" description="candidapepsin" evidence="15">
        <location>
            <begin position="26"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="16">
        <location>
            <begin position="89"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ44310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="405" mass="43037" checksum="A667BD901C6860A1" modified="2010-10-05" version="1">MVSIITFTKNVLVTLAFALLAQGLAIPEDIDKRAEKVVSLDFTVTRKPFNATAHGQHHQSQQQQQQQQQQPAQKRGTVQTSLINEGPSYAATITVGSNKQQQTVIVDTGSSDLWVVDSAAVCQVTYPGQSPTFCKQDGTYKPSSSTTSQNLGKAFSIRYEDGSSSQGTVYKDTVGLGGASITNQQFADVTTTSVDQGILGIGFTGDESSPTYDNVPVTLKKQGIINKNAYSLYLNSASASSGTIIFGGVDNAKYTGSLTALPITSSNELRVQLSTINIAGTTVSASTTPVLDSGTTLTYFSQTIADKLAAAVGAKWNSYYQLYTSSCNLAGNIVFNFAKGVTISVPLSEFVLQDGNSCYFGVSRDSATILGDNFLRRAYAVYDLDGNTISLAQVKYTTSSSISTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ61</accession>
    <name>C4YQ61_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH-ubiquinone oxidoreductase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_02615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ61"/>
    <dbReference type="SMR" id="C4YQ61"/>
    <dbReference type="PaxDb" id="5476-C4YQ61"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02615"/>
    <dbReference type="HOGENOM" id="CLU_081626_0_0_1"/>
    <dbReference type="OMA" id="GYPCRTF"/>
    <dbReference type="OrthoDB" id="2093493at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd22849">
        <property type="entry name" value="NuzM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016813">
        <property type="entry name" value="NADH_Ub_cplx-1_21kDa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37325">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G05910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37325:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G05910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022976">
        <property type="entry name" value="NADH_Oxi_21kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ44350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="21549" checksum="620828ABB166941B" modified="2010-10-05" version="1">MSGGPVPVWKKYTTRPQGIWEKIRQLLVLVPNRSSGNPLVSLFRQVPPGERIKEAQNYKDPVTIPAGDIKGNPYFKRDYRRNYPQVHTFNQTKISGLLNLGSESNPRISIGEKGNKELAVFTNGQDVSLASTLKSVPASVVKGEVLGKSGEPIVAPSLNKFKWEILPEPVHGMYSEAYPCRIFTEKKVRSQSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQF3</accession>
    <name>C4YQF3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TAFII28-like protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_02710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQF3"/>
    <dbReference type="PaxDb" id="5476-C4YQF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02710"/>
    <dbReference type="HOGENOM" id="CLU_069643_0_0_1"/>
    <dbReference type="OMA" id="ANFTDDQ"/>
    <dbReference type="OrthoDB" id="28335at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08048">
        <property type="entry name" value="HFD_TAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045127">
        <property type="entry name" value="TAF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006809">
        <property type="entry name" value="TAFII28_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04719">
        <property type="entry name" value="TAFII28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII28-like protein" evidence="7">
        <location>
            <begin position="194"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="122"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ44442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="343" mass="39703" checksum="267227D89EE6D918" modified="2010-10-05" version="1">MIYNLYNTVETSLDDFWKLVVARYNSLVYLLVSKVALTRKSFTRIRMSTENVSISNNCCLRYFVSNMSSAPEQDTTIPPGTESPHTEHVVENEYQDDDYVSLDEEDEELIWRVFFQKLEKHNKKSNNNDSESDESEESEDTSEEEEEETGDEDFDEDDLSDLSDIDDPALVATYKALMSEKVNKNLGEEEQRRLLISNFTDDQMERFEAYRRMTVNKPGVKKICNGIVGHTIPQIIAVVMAGVSKSFLGEIISKAFEIQERNSKGRLLMDIETKKKQKREIISSLQRGEEIEVDERALKFEGDEIHPLQPEHIREAWRLYQLENSVFSGSRKRKMGDDGPFYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQH9</accession>
    <name>C4YQH9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_02737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQH9"/>
    <dbReference type="PaxDb" id="5476-C4YQH9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02737"/>
    <dbReference type="HOGENOM" id="CLU_2209641_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ44468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="107" mass="12818" checksum="1ECEC154C2CC0554" modified="2010-10-05" version="1">MESTNNSNRSNIFSFLQDIRIRLGVYVNIDLDHDVAWRYICYNYWSIDDINADFLSFLFRLIVVCNRYDHQKNTSNSAQFQFQLQFLLPSFFLRLLYLGCCCSNFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQN4</accession>
    <name>C4YQN4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TECPR1-like DysF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_02793</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQN4"/>
    <dbReference type="PaxDb" id="5476-C4YQN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02793"/>
    <dbReference type="HOGENOM" id="CLU_034954_0_0_1"/>
    <dbReference type="OMA" id="WRLIFIQ"/>
    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052816">
        <property type="entry name" value="Peroxisomal_Membrane_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304:SF1">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="TECPR1-like DysF" evidence="7">
        <location>
            <begin position="156"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="71"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ44523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="588" mass="66926" checksum="A1C824EEEF15F426" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQT6</accession>
    <name>C4YQT6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQT6"/>
    <dbReference type="PaxDb" id="5476-C4YQT6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04433"/>
    <dbReference type="HOGENOM" id="CLU_1618783_0_0_1"/>
    <dbReference type="OMA" id="CDCKNET"/>
    <dbReference type="OrthoDB" id="4024210at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="162" mass="18270" checksum="4C29B9B0893C00EE" modified="2009-07-28" version="1">MALRNYLYAKHDHDTSIDIKINKDNSVMSNITEKVSPSSPSPSDPSDSQKQQRSPMQIQQSRRRIIRIVHKKSSNKLKLNPSVNSIEKLTNNIENVHIEKKKKENCLNDCNLCDCKNETNDNEKDNPLIQVEVDNRVNSGGVGDGGHNEIVSNNEIDFTSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR73</accession>
    <name>C4YR73_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_04572</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR73"/>
    <dbReference type="PaxDb" id="5476-C4YR73"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04572"/>
    <dbReference type="HOGENOM" id="CLU_006686_1_1_1"/>
    <dbReference type="OMA" id="MEMRADY"/>
    <dbReference type="OrthoDB" id="10263032at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1040:FF:000003">
        <property type="entry name" value="N-terminal acetyltransferase A, auxiliary subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1010:FF:000010">
        <property type="entry name" value="Peptide alpha-N-acetyltransferase complex A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021183">
        <property type="entry name" value="NatA_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF2">
        <property type="entry name" value="N(ALPHA)-ACETYLTRANSFERASE 15_16, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12569">
        <property type="entry name" value="NatA_aux_su"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000422">
        <property type="entry name" value="N-terminal-AcTrfase-A_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="612"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="493"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="626"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ46226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="783" mass="90305" checksum="2E375AE13783F58A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR89</accession>
    <name>C4YR89_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">26S proteasome regulatory subunit RPN8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04588</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR89"/>
    <dbReference type="MEROPS" id="M67.973"/>
    <dbReference type="PaxDb" id="5476-C4YR89"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04588"/>
    <dbReference type="HOGENOM" id="CLU_027018_3_0_1"/>
    <dbReference type="OMA" id="HAMSIKT"/>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000004">
        <property type="entry name" value="26S proteasome regulatory subunit rpn-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="18"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00072102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ46242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="330" mass="36741" checksum="1F7A896B0503B654" modified="2010-10-05" version="1">MSTTATSTNELALLDKSVVVSPLVLLSVVDHYNRVAKDSKKRVVGVILGDNSTDTIKVTNSYAIPFEEDEKNPGVWFLDHNFIDSMGEMFKKINAKEKLIGWYHSGPKLKPSDLKINEVFRRYTDNPLLLIVDVQPREVGIPTDAYFAVDDIKNDGSAAEKTFIHVPSLIEAEEAEEIGVEHLLRDIRDQAAGNLSLRVSETHQSLLGLHQKLGEIANYLDKVYQKKLPMNHTILGKLQNVFNLLPNLMQQSGSDLDGGSDSSHALATAFTVKTNDELMIIYISTLVRAIIAFHDLIENKLENKKLNENKAQASVAESSLNSEKKDSIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRG8</accession>
    <name>C4YRG8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_04667</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YRG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04667"/>
    <dbReference type="HOGENOM" id="CLU_003363_0_0_1"/>
    <dbReference type="OMA" id="KGHNRFS"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060258">
        <property type="term" value="P:negative regulation of filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14081">
        <property type="entry name" value="STKc_BRSK1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000394">
        <property type="entry name" value="Serine/threonine-protein kinase HSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031850">
        <property type="entry name" value="Fungal_KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16797">
        <property type="entry name" value="Fungal_KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="65"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="412"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="471"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="599"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="992"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1095"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1263"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="637"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="471"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="510"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="527"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="610"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1095"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1131"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1159"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1191"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1286"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ46321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1456" mass="162816" checksum="16D982A41FE38739" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRI4</accession>
    <name>C4YRI4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ46337.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000001429"/>
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    </evidence>
    <sequence length="1019" mass="111056" checksum="3FE16CB0961AD1B2" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
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    <name>C4YRP4_CANAW</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">CAWG_04747</name>
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        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
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                <person name="Srikantha T."/>
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                <person name="Berman J."/>
                <person name="Berriman M."/>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="Proteomes" id="UP000001429"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRQ3</accession>
    <name>C4YRQ3_CANAW</name>
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        <recommendedName>
            <fullName evidence="7">Thiamine pyrophosphokinase</fullName>
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    </protein>
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        <name evidence="9" type="ORF">CAWG_04756</name>
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        <name type="scientific">Candida albicans (strain WO-1)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>thiamine + ATP = thiamine diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11576"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the thiamine pyrophosphokinase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRQ3"/>
    <dbReference type="SMR" id="C4YRQ3"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04756"/>
    <dbReference type="HOGENOM" id="CLU_044237_0_0_1"/>
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    <dbReference type="OrthoDB" id="25149at2759"/>
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        <property type="reaction ID" value="UER00597"/>
    </dbReference>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016966">
        <property type="entry name" value="Thiamin_pyrophosphokinase_euk"/>
    </dbReference>
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        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031057">
        <property type="entry name" value="Thiamin_pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="Thiamin pyrophosphokinase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase thiamin-binding" evidence="8">
        <location>
            <begin position="242"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ46406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="327" mass="37336" checksum="C61A1223D4E70057" modified="2009-07-28" version="1">MSEDSELIEQVIEQPDSLIISPPSDSSSSSSYNHIQPFVYLESTATTQTNHNVLLILNQKITIDLISLWKKCEIIVCADGGANSLYEYFNDNNHHHHHENLQRSDYIPDYIVGDFDSISPDVKTYYESHGSKIIRQSSQYYNDFTKSIHCIQLHYQLNHTKENWFESIDEVDGLAKLWNGLNNSSDVVVDIDITIYVLNAIGGRFDQTVQSINQLYIMNEDYPKVTVFFITTNDIIFLLKKGVNYISYKNRLMFHKDNGSSPTPTCGLLPLSNKTPIILNSYGLKYDMRNWKTEMLGQVSSSNRISGETGFIVECSDDIVMNIEIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRS1</accession>
    <name>C4YRS1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein kinase MEC1</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ATR homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">DNA-damage checkpoint kinase MEC1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Mitosis entry checkpoint protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CAWG_04778</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRS1"/>
    <dbReference type="PaxDb" id="5476-C4YRS1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04778"/>
    <dbReference type="HOGENOM" id="CLU_000178_9_0_1"/>
    <dbReference type="OMA" id="NILVDCC"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000033">
        <property type="entry name" value="Serine/threonine-protein kinase MEC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF125">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MEC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="20">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="21">
        <location>
            <begin position="217"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EEQ46424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="249" mass="28445" checksum="6180AD8E0CEE8D30" modified="2009-07-28" version="1">MNVPTMKGVISEPRKRQGIPINERKVFMHIDSLQKAKKKDSKQLDKLVAGFRAIMDRCPPVLHTWFVEQFSDPSAWYMARNAFTRSSAVMSMVGYIMGLGDRHCENILIFKNTGAVLHIDFDCLFEKGTTLPTPEIVPFRLTQNMVDAMGITGVDGIYRITCEVTGTLLRENEQILMNILETLIYDPLIDWRNHNPREDLSKVRKKIRGLINEDEGLPMNIHGQVDVLIQEATSLERLSQMYAGWAAYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRT9</accession>
    <name>C4YRT9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRT9"/>
    <dbReference type="PaxDb" id="5476-C4YRT9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04796"/>
    <dbReference type="HOGENOM" id="CLU_1360242_0_0_1"/>
    <dbReference type="OMA" id="SVIMCEC"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22642" checksum="7BD08D984DE887BC" modified="2009-07-28" version="1">MSDARICVGLFLKVLQLVGDLACFATSIKAGGHYNGLIIAVTVFSFIYNIFSNCLGWFGMKGTVDTEDVRAYRQFVLGGGTLFFLFYIGSSIFQLFTGYNNNLNNFGYGSHLKPYHHYASWCIGVTCAVLYCMSVIMCECWGITFASVHDLSTEFFERQPFKFACSVFDKSQVDHDCEDNNDIGLKSMQHNTSNNTGTNTKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRW3</accession>
    <name>C4YRW3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycerophosphocholine phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRW3"/>
    <dbReference type="PaxDb" id="5476-C4YRW3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04820"/>
    <dbReference type="HOGENOM" id="CLU_005444_1_0_1"/>
    <dbReference type="OMA" id="WTPMEHA"/>
    <dbReference type="OrthoDB" id="197419at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047389">
        <property type="term" value="F:glycerophosphocholine phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14484">
        <property type="entry name" value="SPX_GDE1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000845">
        <property type="entry name" value="Glycerophosphocholine phosphodiesterase GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SPX" evidence="5">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="346"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="458"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="492"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="6">
        <location>
            <begin position="817"/>
            <end position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ46466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1162" mass="130898" checksum="F0A68E66048842EA" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS47</accession>
    <name>C4YS47_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_04905</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Lipid-anchor</topology>
            <topology evidence="10">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS47"/>
    <dbReference type="SMR" id="C4YS47"/>
    <dbReference type="PaxDb" id="5476-C4YS47"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04905"/>
    <dbReference type="HOGENOM" id="CLU_021855_1_0_1"/>
    <dbReference type="OMA" id="GVNDYSW"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000032">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF5">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9 10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005125144" description="1,3-beta-glucanosyltransferase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="395"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="396"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ46550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="451" mass="48996" checksum="98E90849E77A8D79" modified="2010-10-05" version="1">MLFRSLVTYLSLVSSVLSIASIKVEGNAFWDSESGDRFYIRGVDYQPGGSSELEDPLADTNVCERDVKYFQELGINTIRVYSIDNTKNHTECMDTLAKAGIYVILDVNTPHSSITRSDAACSYNTDYLQEVFASIVEFAQFDNTLGFFAGNEVINDGPSLEAAPYVKAVVRDMKTFIKNRGFRTIPVGYSAASVDEYRLPSGLYFNCGDDDMARIDMYGINDYSWCGDASMTTSQYSQQMKDFANYTVPLFFSEFGCNAKRPRPFSEIEAIYSTEMSSVFSGGLVYEYSEEASNYGLVELKGDSVTTNDDFDNLKSQFEKTKNPSGDGGYLKSTGGNKCPPKSNIWNVTEEIPDTPKGALKYLKGLAEPTGHGFDAYVQGNCNAKGNNVDDTGNYTSSITASSRASPSQTSQVSSSSATSANSTSSKKNDAAVEGAGFLSVIALAAGIALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSN7</accession>
    <name>C4YSN7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_05105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSN7"/>
    <dbReference type="PaxDb" id="5476-C4YSN7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05105"/>
    <dbReference type="HOGENOM" id="CLU_007625_3_0_1"/>
    <dbReference type="OMA" id="AHMEAWD"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14369">
        <property type="entry name" value="CUE_VPS9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041545">
        <property type="entry name" value="DUF5601"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041804">
        <property type="entry name" value="Vps9_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18151">
        <property type="entry name" value="DUF5601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="VPS9" evidence="4">
        <location>
            <begin position="449"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="3">
        <location>
            <begin position="721"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="623"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="672"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="634"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="687"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ46740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="765" mass="86124" checksum="82D000EF3CC6EE36" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSQ8</accession>
    <name>C4YSQ8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_05126</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycerophosphoryl diester phosphodiesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSQ8"/>
    <dbReference type="PaxDb" id="5476-C4YSQ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05126"/>
    <dbReference type="HOGENOM" id="CLU_729591_0_0_1"/>
    <dbReference type="OMA" id="RIQFGIW"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034479">
        <property type="term" value="F:phosphatidylglycerol phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08570">
        <property type="entry name" value="GDPD_YPL206cp_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000087">
        <property type="entry name" value="Glycerophosphodiester phosphodiesterase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052271">
        <property type="entry name" value="GDPD-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42758">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42758:SF2">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GP-PDE" evidence="8">
        <location>
            <begin position="24"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ46761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="405" mass="47716" checksum="446DAB8518BA051A" modified="2009-07-28" version="1">MSTSSIIPKVAYQSLNRMTSTISPVIVGHRGFKSKYPENTFLGFDKCFEAGGTVIETDLWLTKDNEIVISHDQYTKRVFVDSDGNPTNYNITETPYDPILKHLKTIEGGYPLFTFKELLQWFKKYIDTTQSNDHKLQLDIKRFNPTKITKFIVQDLLTVHDDISWWYHRIQFGIWDLNFLKYLNQSDYFQDKFGKVNKFGYDQFDIFNISVNWRDSIHYINYNFYLDESSPVDRVKIKLTGVSLIYISTWSAGFLTKFVPLLRIQNLKLYSWTVNNKLQYSYLNKVGKLANLVEYGVISDYPDVMAKYKQEDESLTETESGEMSPLIKSESKDYYNEDGDLSIDLTLQQKFYHWIFVQFNSLVGKRVTIDEQHFATKVDENQVRSININPFFQWMFQKLQKYGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSS9</accession>
    <name>C4YSS9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase MCK1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_05148</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSS9"/>
    <dbReference type="PaxDb" id="5476-C4YSS9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05148"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_20_1"/>
    <dbReference type="OMA" id="QHLAMEC"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF4">
        <property type="entry name" value="PROTEIN KINASE MCK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="30"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="55"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ46782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="407" mass="46615" checksum="FEE42C76D45C24DA" modified="2009-07-28" version="1">MPQSSSTFINEYTLPDVVENSSSRASKMTIKEYKRIGEGAFGTVVEAMLKYETNSSKGNDGTGSHLLGHFRHHSHSDKDNNNTTSNNNNNNNKDGEWLGPFAIKRVPAQTEYKSRELEILRFVSHPNIVSLRFFFDKKSSSDNKVYQNLVMECLPSNLQSEIKYYRQSKYTIPYPHMKAYTFQLARAMLYLHGYGISHRDIKPSNILVDPNTVRLKICDFGSAKKLEPNQPSVSYICSRYYRAPELIVGCSLYTTKIDIWGLGCVIAEMFLGKPIFQGQSPESQLKEIAKLLGPPPNTFFFKSNPQYRGNMYTTRLFNCSIEERFKQIFSNSPSDAIDLLMKILVYDPDVRASPRRVLIHPFFDELKSSQFKVYPRGSSTPIELHLFNFSEYELELLGSLKNEFVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YST3</accession>
    <name>C4YST3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_05152</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial inner membrane magnesium transporter required for mitochondrial magnesium homeostasis. Modulates the conductance of the MRS2 channel. Involved in the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms homooligomers. Interacts with MRS2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YST3"/>
    <dbReference type="PaxDb" id="5476-C4YST3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05152"/>
    <dbReference type="HOGENOM" id="CLU_025144_1_0_1"/>
    <dbReference type="OMA" id="MIPIRSS"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000056">
        <property type="entry name" value="Mitochondrial inner membrane magnesium transporter LPE10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="337"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ46786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="453" mass="51173" checksum="2A7073B0DC4B83F8" modified="2009-07-28" version="1">MIPIRSSITRILPNGFLSKPFLRQLNKKSKPNPHKNKNFDSFNEVFIHKTLLSSIKQHNDTDYVRCSIFNANGDMIQHGKEILKSQFIKRYNLTPRDFRKFNWQRSATGTTTSSSSSSSSAGQTSSGTSKSSSLSLSSSSPHSTISALSLSNSSLGSSTNVDIVPNITIRRNSILVQLLNIRALINHDQLIIFDNSSSFQNSHVSSYTHSQFLKDLSQRLKSTNLDGLPFEFKALEGILIYIVSNLNMEMKVHNTVLQNIITGLEDSIDRNKLRYLLIESKKIHQFHRKITLIKNCLEDLLENDDELNDLYITEKFNSEGDGQPRQGTNHEEIEMLLENYYQTIDEIVQIVENLKNQIKTTEDLINVVLDSNRNQLMLLGLKFSTGLLSMGVALYVSALYGMNLENFIEEIDGGFEVVTVVSTIALIALLLFSVKQLKKVEKVTMTSLNDQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSZ4</accession>
    <name>C4YSZ4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Alpha-1,2-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_05691</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSZ4"/>
    <dbReference type="PaxDb" id="5476-C4YSZ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05691"/>
    <dbReference type="HOGENOM" id="CLU_013298_1_0_1"/>
    <dbReference type="OMA" id="HVMNERY"/>
    <dbReference type="OrthoDB" id="4484309at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="723"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="723"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ47130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="756" mass="87256" checksum="B4B48987403EF1E9" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT02</accession>
    <name>C4YT02_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_05699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT02"/>
    <dbReference type="PaxDb" id="5476-C4YT02"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05699"/>
    <dbReference type="HOGENOM" id="CLU_016174_1_1_1"/>
    <dbReference type="OMA" id="YFSFNPR"/>
    <dbReference type="OrthoDB" id="4021105at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050715">
        <property type="entry name" value="LRR-SigEffector_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45752:SF187">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45752">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ47138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="614" mass="70506" checksum="3F3325BA216476EB" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT09</accession>
    <name>C4YT09_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 12">Protein AF-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">YAF9</name>
        <name evidence="15" type="ORF">CAWG_05707</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for an H2A variant leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The coiled-coil domain is required for assembly into the NuA4 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the YAF9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT09"/>
    <dbReference type="PaxDb" id="5476-C4YT09"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05707"/>
    <dbReference type="HOGENOM" id="CLU_051385_2_1_1"/>
    <dbReference type="OMA" id="VKPYHNE"/>
    <dbReference type="OrthoDB" id="16041at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16908">
        <property type="entry name" value="YEATS_Yaf9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1970:FF:000007">
        <property type="entry name" value="Protein AF-9 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23195">
        <property type="entry name" value="YEATS DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0010">Activator</keyword>
    <keyword evidence="4 12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="14">
        <location>
            <begin position="8"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ47145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="254" mass="29504" checksum="17CB3D8D3EECD805" modified="2009-07-28" version="1">MSSTHSRRIKFVSISVPILYGNHAIKLTPEKRKPTTPPEHTHEWTVFFKPVLGDIDLTPLIKKVTFKLHETYENPVRTLESPPYQVTETGWGEFEIIIKLHFQPGVELGINEKNFQIFHALKLHPYNPQAPQAQQPQVQQSQAQPPQQQFGGEGGSVGTIIRERENGEVHSVLYDELVFNEPTEKTFEILTSKPVNLIPYKLSNLDKRDQEYIRPDEIDELNRMDIYIDKVKQEIENQRNQYKLLEQEKLALLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT12</accession>
    <name>C4YT12_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein RER1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_05710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RER1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT12"/>
    <dbReference type="PaxDb" id="5476-C4YT12"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05710"/>
    <dbReference type="HOGENOM" id="CLU_074889_0_0_1"/>
    <dbReference type="OMA" id="GWYVVCY"/>
    <dbReference type="OrthoDB" id="448250at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016013">
        <property type="entry name" value="AtER_Rer1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ47148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="199" mass="23986" checksum="4DC727A62B480F2E" modified="2009-07-28" version="1">MAIELPFEIPKDNPVYINIQKFSVTYQKLVDESVPYTSRRWIGFGILLSLFLLRIFLSQGWYIICYALGIYLLNLFLAFLTPKFDPSLEQELKNESIEEGLDQEDPISQQSNQKYDDDDEFRPFIRRLPEFKFWYNAIRATIIALILTFFNIFDIPVFWPILLMYFIILFTLTMRRQIQHMIKYKYLPFDLGKTRYRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT14</accession>
    <name>C4YT14_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4259 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_05712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT14"/>
    <dbReference type="PaxDb" id="5476-C4YT14"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05712"/>
    <dbReference type="HOGENOM" id="CLU_1602466_0_0_1"/>
    <dbReference type="OMA" id="CELWSET"/>
    <dbReference type="OrthoDB" id="4008472at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025355">
        <property type="entry name" value="DUF4259"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14078">
        <property type="entry name" value="DUF4259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ47150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="20541" checksum="34DBD6E6DF13F562" modified="2010-10-05" version="1">MGAWGAGYFDSDMSCDCWAELRHENTENALELIITYLQNVVNNNSYIEVDETDAAIVCSLLVIVLFTNYNWINETFTEKDIPKYVQEELEIFLNRYQKNWDENYKNKQIEIKIKIGEQKEVVSIPKLANLSLKQVLNPKISESCELWVETEYYDEWKQRIQILVDKLEQIQTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTA8</accession>
    <name>C4YTA8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sister chromatid cohesion protein DCC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTA8"/>
    <dbReference type="SMR" id="C4YTA8"/>
    <dbReference type="PaxDb" id="5476-C4YTA8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05394"/>
    <dbReference type="HOGENOM" id="CLU_034504_0_0_1"/>
    <dbReference type="OMA" id="DSESWPF"/>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034088">
        <property type="term" value="P:maintenance of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019128">
        <property type="entry name" value="Dcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395:SF6">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09724">
        <property type="entry name" value="Dcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="39150" checksum="966750168A93B2F0" modified="2010-10-05" version="1">MSEYSVYQQLNEDTNATKYTYKLLQLPSKILNQLESKSTNLYIKSDINSLALCTDSETFKLRQMNHSNTVLLLNKEPDNKLIGFQKTSYEYELTEIKGSIDTSDIPIFNGQTAQQPIDLIALEDNSICSHQEFLSNWYELGGCEIDNGAYIMSADIITELLYLLITKLMSLQVHEFSPEDVSSIITPPYNDSMLTSIIHKFCTIESEKYQLNDLKITQWFGIVEMSKINHKMTDISEFLLNWKTSLPSFYNPPLDISQLAGYYCSPIENKILYVDPESLSENLSQRFKELFELDKSWNYDEFIPFIKKFVPAGKKVDSIILKYGKKKKVGRDRFIVCPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTV7</accession>
    <name>C4YTV7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_05603</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Tom70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTV7"/>
    <dbReference type="PaxDb" id="5476-C4YTV7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05603"/>
    <dbReference type="HOGENOM" id="CLU_017516_1_0_1"/>
    <dbReference type="OMA" id="QWRGDIE"/>
    <dbReference type="OrthoDB" id="2942533at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000357">
        <property type="entry name" value="Mitochondrial proteins import receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000374">
        <property type="entry name" value="Mitochondrial proteins import receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="420"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="34"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ47048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="636" mass="70356" checksum="409D74B873873101" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-11-01" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>P43078</accession>
    <accession>C4YD44</accession>
    <name>PTPX_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>Probable tyrosine-protein phosphatase</fullName>
            <ecNumber>3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CPP1</name>
        <name type="ORF">CAWG_00432</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1992-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Csank C."/>
                <person name="Dignard D."/>
                <person name="Thomas D.Y."/>
                <person name="Whiteway M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48"/>
    <dbReference type="EMBL" id="L01038">
        <property type="protein sequence ID" value="AAC05307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S43743">
        <property type="entry name" value="S43743"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P43078"/>
    <dbReference type="SMR" id="P43078"/>
    <dbReference type="PaxDb" id="5476-P43078"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00432"/>
    <dbReference type="HOGENOM" id="CLU_032220_0_0_1"/>
    <dbReference type="OMA" id="INYSPKH"/>
    <dbReference type="OrthoDB" id="426001at2759"/>
    <dbReference type="PHI-base" id="PHI:66"/>
    <dbReference type="PHI-base" id="PHI:6828"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14521">
        <property type="entry name" value="DSP_fungal_SDP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000094">
        <property type="entry name" value="Probable tyrosine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0904">Protein phosphatase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000094918" description="Probable tyrosine-protein phosphatase">
        <location>
            <begin position="1"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="428"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="107"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="188"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="1">
        <location>
            <position position="516"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAC05307." evidence="4" ref="1">
        <original>Q</original>
        <variation>K</variation>
        <location>
            <position position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="597" mass="65586" checksum="B0F1DE22ACC9C78C" modified="2011-10-19" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCV9</accession>
    <name>C4YCV9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rad60/SUMO-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_00343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCV9"/>
    <dbReference type="PaxDb" id="5476-C4YCV9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00343"/>
    <dbReference type="HOGENOM" id="CLU_615376_0_0_1"/>
    <dbReference type="OMA" id="MHIYPEL"/>
    <dbReference type="OrthoDB" id="3365399at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17080">
        <property type="entry name" value="Ubl_SLD2_Esc2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad60/SUMO-like" evidence="2">
        <location>
            <begin position="412"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ42145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="485" mass="55597" checksum="FD9DF21B56D18804" modified="2009-07-28" version="1">MDSNSFITKGEGDQPSPYNSTVDESILNEVSSENNELTPKLSRELNDSDDSPKRKKKKRSLLDDDFFSLAGSFEKRKKKHKHKHKQKEKEKGIDVQDQVIENDGLIEVPIPQSTKVSTDKEISSELASSQSDIPRKNINTVQPEISLSRSVSITPPLVDRNKIRKEVMSRLNKEHMRSKIPDMEDSEEESDHELEELLKLKSQMPKSQTELSPETYTFDDESEKKRKYIVRVTSKLPAVHNQTLEVDFGTKGLKTFEKILKAAVDYFKSALMSVLTPPQLSRYRPEAASLVWVEGRKLVHPFFTPKTLRVPPPAEFNPLFEKIENMKPTIIKFFLIPKEYDTTFMHIYPELQANRPIEDAIEPIEISENEFNSNESDDNEEEEEEEVVAQEEQPTSKAPSSEEPVGPNLFVIGLKGKDNKRVEVKVSPETQLRKLLSYYLRHKGLSEDTVDLSKAKLIFDDEEMDLNDTVGDTELEEDYEIQVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCZ9</accession>
    <name>C4YCZ9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS5m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_00386</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCZ9"/>
    <dbReference type="PaxDb" id="5476-C4YCZ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00386"/>
    <dbReference type="HOGENOM" id="CLU_037994_0_0_1"/>
    <dbReference type="OMA" id="RGKIYKS"/>
    <dbReference type="OrthoDB" id="309483at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000022">
        <property type="entry name" value="28S ribosomal protein S5, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000041">
        <property type="entry name" value="37S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="10">
        <location>
            <begin position="174"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ42185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="336" mass="37724" checksum="5ACDA3BFA2703310" modified="2009-07-28" version="1">MLKRTLQPISVLKRCLTTSRTVFASETGSKSSNQSTNNKINKHTEFLSKYYNPEILQSIQAAESLVTPEQYLNLQLKGSDAKSKVGPTDEEFDYSFNDPEWEEPIIYPNQGLGRAPYPEIPQVSSPDRSALKIRFSDAPVATQKDEPTGIKTPQQIAQELSDLTGLDERYIRRLYVRPLIMKRVSLKTAKGNIANFFVLSVAGDKNGMAGLGIGKSRDGIRTAATKAHWNAVKNLTPVYRYEDRTILGSFEYKYHATKLKFSPAPIGFGLRCNKNIFEICQAAGIKDLKGKIYKSRNPLTVANGFFKALTQQRSLEELAANRGKKIVELRKVYYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD40</accession>
    <name>C4YD40_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Endoplasmic oxidoreductin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CAWG_00428</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD40"/>
    <dbReference type="PaxDb" id="5476-C4YD40"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00428"/>
    <dbReference type="HOGENOM" id="CLU_023061_1_0_1"/>
    <dbReference type="OMA" id="CYKDRLH"/>
    <dbReference type="OrthoDB" id="269384at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017205">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 17" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946364" description="Endoplasmic oxidoreductin-1" evidence="20">
        <location>
            <begin position="22"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="98"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="369"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EEQ42226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="23">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="66985" checksum="D0071E8704D8EC07" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDA3</accession>
    <name>C4YDA3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein EFR3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_00493</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDA3"/>
    <dbReference type="PaxDb" id="5476-C4YDA3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00493"/>
    <dbReference type="HOGENOM" id="CLU_333688_0_0_1"/>
    <dbReference type="OMA" id="LQCYPAG"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039786">
        <property type="entry name" value="EFR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049150">
        <property type="entry name" value="EFR3_HEAT-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766:SF1">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21072">
        <property type="entry name" value="EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="540"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="794"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="550"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ42289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="958" mass="107701" checksum="BF873BD010A28D58" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDT2</accession>
    <name>C4YDT2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_00680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDT2"/>
    <dbReference type="PaxDb" id="5476-C4YDT2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00680"/>
    <dbReference type="HOGENOM" id="CLU_021255_2_1_1"/>
    <dbReference type="OMA" id="PAIFDCQ"/>
    <dbReference type="OrthoDB" id="270602at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02958">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14346">
        <property type="entry name" value="UBA_Ubx5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF6">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="457"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ42468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="546" mass="62602" checksum="3183A128FBFB80A5" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDU7</accession>
    <name>C4YDU7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ammonium transporter AmtB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_00695</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDU7"/>
    <dbReference type="PaxDb" id="5476-C4YDU7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00695"/>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_1"/>
    <dbReference type="OMA" id="GCDFKFS"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="21"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="327"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ42483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="580" mass="65264" checksum="20C8A21AF051A198" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDZ3</accession>
    <name>C4YDZ3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[RNA-polymerase]-subunit kinase</fullName>
            <ecNumber evidence="2">2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_00742</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.23" evidence="2"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDZ3"/>
    <dbReference type="PaxDb" id="5476-C4YDZ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00742"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_0_1"/>
    <dbReference type="OMA" id="GIHHCHR"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07841">
        <property type="entry name" value="STKc_CDK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000097">
        <property type="entry name" value="Putative cyclin-dependent kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000498">
        <property type="entry name" value="Serine/threonine-protein kinase KIN28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037770">
        <property type="entry name" value="CDK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="24"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="307"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="30"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 11">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ42529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="343" mass="38850" checksum="AABE97D0A8CDAC95" modified="2009-07-28" version="1">MSTAAVATKPSVTSKPATKQVSNYTKEKKVGEGTYAVVYLGKQITTKRQIAIKEIKTGLFKDGLDMSALREVKYLQELKHPNVIELVDVFSATNNLNLVLEFLPCDLEVLIKDKSIVFKSADIKSWLLMTLRGIHHCHRNFILHRDLKPNNLLLAPDGQLKIADFGLARALVNPNEDLSSNVVTRWYRAPELLFGARHYTGAVDIWSIGIIFAELMLRIPYLPGKDDVDQLDVTFRAYGTPTEQIWPNVSSLPMYNALHVYPPPSRQELRNRFSAATEKALDLLISMTQLDPSRRCDSTLALLHDYFTESPRPTDPKKLPKKSSPEKRENEDEQNNGSKRRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YE09</accession>
    <name>C4YE09_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_00759</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="C19.A48"/>
    <dbReference type="PaxDb" id="5476-C4YE09"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00759"/>
    <dbReference type="HOGENOM" id="CLU_001060_7_1_1"/>
    <dbReference type="OMA" id="PYCEKPE"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF24">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUSP" evidence="10">
        <location>
            <begin position="54"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="327"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="706"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="837"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="876"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1220"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="722"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="930"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1226"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1268"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1282"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1297"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1336"/>
            <end position="1345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ42545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1362" mass="156420" checksum="9E8706308922A994" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEE2</accession>
    <name>C4YEE2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_00899</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial metal transporter involved in mitochondrial iron accumulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEE2"/>
    <dbReference type="PaxDb" id="5476-C4YEE2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00899"/>
    <dbReference type="HOGENOM" id="CLU_013430_12_2_1"/>
    <dbReference type="OMA" id="GVYFHSQ"/>
    <dbReference type="OrthoDB" id="435980at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000013">
        <property type="entry name" value="Cation efflux family protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF15">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0409">Iron storage</keyword>
    <keyword evidence="5" id="KW-0410">Iron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="12">
        <location>
            <begin position="151"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="12">
        <location>
            <begin position="297"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="78"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="486"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ42678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="517" mass="57164" checksum="66DDF2138B2A6F88" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEH1</accession>
    <name>C4YEH1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Urea amidolyase</fullName>
            <ecNumber evidence="11">3.5.1.54</ecNumber>
            <ecNumber evidence="12">6.3.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_00928</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>urea + hydrogencarbonate + ATP = urea-1-carboxylate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20896"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15832"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>urea-1-carboxylate + H2O + 3 H(+) = 2 NH4(+) + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:19029"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15832"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (allophanate route): step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (allophanate route): step 2/2.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.54" evidence="11"/>
    <dbReference type="EC" id="6.3.4.6" evidence="12"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="C4YEH1"/>
    <dbReference type="PaxDb" id="5476-C4YEH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00928"/>
    <dbReference type="HOGENOM" id="CLU_002162_4_1_1"/>
    <dbReference type="OMA" id="GGMYMCI"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004039">
        <property type="term" value="F:allophanate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004847">
        <property type="term" value="F:urea carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Multifunctional urea amidolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Urea amidolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053844">
        <property type="entry name" value="AH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014085">
        <property type="entry name" value="Allophanate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014084">
        <property type="entry name" value="Urea_COase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02713">
        <property type="entry name" value="allophanate_hyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006043">
        <property type="entry name" value="PRK08186.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00724">
        <property type="entry name" value="urea_amlyse_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02712">
        <property type="entry name" value="urea_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF128">
        <property type="entry name" value="UREA AMIDOLYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21986">
        <property type="entry name" value="AH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02626">
        <property type="entry name" value="CT_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00797">
        <property type="entry name" value="AHS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160467">
        <property type="entry name" value="PH0987 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="18" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="17">
        <location>
            <begin position="614"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="16">
        <location>
            <begin position="733"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="15">
        <location>
            <begin position="1737"/>
            <end position="1813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ42707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1813" mass="200424" checksum="7E64BCFA1527F7C5" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEX2</accession>
    <name>C4YEX2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_01081</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEX2"/>
    <dbReference type="SMR" id="C4YEX2"/>
    <dbReference type="PaxDb" id="5476-C4YEX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01081"/>
    <dbReference type="HOGENOM" id="CLU_046483_4_0_1"/>
    <dbReference type="OMA" id="WPIEMAR"/>
    <dbReference type="OrthoDB" id="426865at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000007">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001749">
        <property type="entry name" value="PRK00474.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ42858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="142" mass="15739" checksum="19408A7791FF4356" modified="2009-07-28" version="1">MSTQSVQTFGKKKTATAVAHVKAGKGLIKINGSPITLVQPEILRFKVYEPLTLVGLDKFQGIDIRVKVTGGGHVSQVYAIRQAIAKGLVAYHQKYVDEASKNELKKIFASYDKTLLVADSRRMEPKKFGGRGARARFQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEZ2</accession>
    <name>C4YEZ2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_01101</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEZ2"/>
    <dbReference type="PaxDb" id="5476-C4YEZ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01101"/>
    <dbReference type="HOGENOM" id="CLU_526741_0_0_1"/>
    <dbReference type="OMA" id="MMGTIAI"/>
    <dbReference type="OrthoDB" id="4026435at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="426"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ42878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="517" mass="58919" checksum="C6ACD939D9937AA2" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF13</accession>
    <name>C4YF13_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Pyridoxal 5'-phosphate synthase glutaminase subunit</fullName>
            <ecNumber evidence="4">3.5.1.2</ecNumber>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_01123</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of a SNZ isoform.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="4"/>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF13"/>
    <dbReference type="PaxDb" id="5476-C4YF13"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01123"/>
    <dbReference type="HOGENOM" id="CLU_069674_0_1_1"/>
    <dbReference type="OMA" id="GMIMLAD"/>
    <dbReference type="OrthoDB" id="2039at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903600">
        <property type="term" value="C:glutaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008614">
        <property type="term" value="P:pyridoxine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000042">
        <property type="entry name" value="Pyridoxine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005639">
        <property type="entry name" value="Glut_amidoT_SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="12">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="12">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="63"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="156"/>
            <end position="157"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00078497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ42899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="249" mass="28334" checksum="03D358B31BF8E05A" modified="2009-07-28" version="1">MTIDRSVTIGVLALQGAFREHIAYFKHLIESNPDEYAVYDFDIKEVRTKEDLELCDSLVIPGGESSSMSYIAERTELLPHLYKFVSDESKSVWGTCAGLIFLSKQLINGIENQRVLGALDIEVSRNAFGRQIDSFEQSLDFSSFIPGCTAFPTVFIRAPVVTKILNQKDSLKEGVIRSNNSYQNQAPVKVLYSLKNYDGKDHELIVAVQQGHILGTSFHPELAEDYRFHKWFLDEFVIKKSQQYIDRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF67</accession>
    <name>C4YF67_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_01179</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF67"/>
    <dbReference type="PaxDb" id="5476-C4YF67"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01179"/>
    <dbReference type="HOGENOM" id="CLU_046313_2_3_1"/>
    <dbReference type="OMA" id="ATHAWVN"/>
    <dbReference type="OrthoDB" id="432299at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000001">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="116"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ42953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="194" mass="21425" checksum="654F9AE926D14D11" modified="2009-07-28" version="1">MTSRLDELNKKLQQNTNQGLASSTSSSSSRSSLKPPTSSSSLRPPPTMGSNRGLFPAINSAQRAANATTTSSAAANQRKKVILQPGHSPLDWAQLNRTQPRHKLRGVPANTPPPQYISINKQELQKHKSLQDCWTCINGKVYNITPYINFHPGGVEEIMKCAGKDGTSLFNKYHSWVNVDRMLENCIVGVFHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF73</accession>
    <name>C4YF73_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Late endosome and vacuole interface protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_01185</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM208 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF73"/>
    <dbReference type="PaxDb" id="5476-C4YF73"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01185"/>
    <dbReference type="HOGENOM" id="CLU_094308_1_1_1"/>
    <dbReference type="OMA" id="GRPKYDA"/>
    <dbReference type="OrthoDB" id="10012212at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008506">
        <property type="entry name" value="SND2/TMEM208"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05620">
        <property type="entry name" value="TMEM208_SND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="142"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ42959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20603" checksum="3F80097ABE360CB8" modified="2009-07-28" version="1">MASASAKKLAVANTNILNQLLIISASINIIVLLIISIFHRPSSYKPWIIFSIPSIFLQYSLEKFGRPKYTNGNSLVSSGEDIRLSGSLYEYYFDVIYLTWGFDILMIIFGSNKVWYGYLIIPGFAIYKLSNFILPFIKKNKSNGSTPEEQQAETKQTNSATSKRQQKLQARREKGPAVRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFE0</accession>
    <name>C4YFE0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_01257</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFE0"/>
    <dbReference type="PaxDb" id="5476-C4YFE0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01257"/>
    <dbReference type="HOGENOM" id="CLU_449757_0_0_1"/>
    <dbReference type="OMA" id="LYCISYL"/>
    <dbReference type="OrthoDB" id="1928087at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051294">
        <property type="entry name" value="HORMA_MeioticProgression"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225">
        <property type="entry name" value="HORMA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225:SF7">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN HOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="7">
        <location>
            <begin position="10"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="607" mass="69409" checksum="1197A0506604138A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFF2</accession>
    <name>C4YFF2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFF2"/>
    <dbReference type="PaxDb" id="5476-C4YFF2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00002"/>
    <dbReference type="HOGENOM" id="CLU_000680_27_2_1"/>
    <dbReference type="OMA" id="KWINWIM"/>
    <dbReference type="OrthoDB" id="4097129at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="91"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ41815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="325" mass="36718" checksum="FC89BF0D456D35C3" modified="2009-07-28" version="1">MLNVASNYMSGLYKKDTKVRHYIENYLAKFPKRLGDDDRLLLAKPITLEELTCELDEASGDKTPGEDGISMKCLKNLWGVCGPALVKEANKIRKTGNLPKDFQRIIITLIPKHGNSIKEINNVRPISLINCALRLISSVVNRRIQKAMINSKIWHNNQHGFIPGRTIQDVTQKLATTIDAIRRHTSSNHAVILIDFRKAFDNINCLYLLLTLTKLNIDDDTIRYCMAVTADHFGQIQLNNRLSSSFKLGKGVRQENPLSPALFNIGLEPLFHKIDQTLTAVKLENGYSVNVLAYADDITIFVDNEGGANLLRKFYTTLKKFSVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFF4</accession>
    <name>C4YFF4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_00004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFF4"/>
    <dbReference type="PaxDb" id="5476-C4YFF4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00004"/>
    <dbReference type="HOGENOM" id="CLU_067363_0_0_1"/>
    <dbReference type="OMA" id="SINANFP"/>
    <dbReference type="OrthoDB" id="1914839at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ41817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="43268" checksum="25855435085447D8" modified="2009-07-28" version="1">MWPVSHVGLNDDGSMVVLVSTRQGVIQGYDKRELKWTSSVHFRGKVLESFFRRRTVPGFLARKMIRKRRGSDASMSSVNSSINANFPPPIQMKSFGQKQRERTSREEFVMVMDSGEILVVSCNDGKVQSYDVKQQLVSAIKIRTPRVMDRIVVQTKELDIIVVNIVNNSMKSRKLEVAPSKSCGIFPVEFVGFFIRVDGLECQLIDVNTGVVIKSFGVGNMKVNSLRVSYPEPSHCRFCGSAAISSFSVVYEIEGVVVVHTFRVDKKAICLRVERDPREIRCVGFCGAEEKVDWYENVVGYEVTSVNSMIGVVQKSSGLRNRKIKQAKEYELMVVSLGSGKAEYYEYKVDGVLWGVERYGHKSVILNQGRRMEVVYVGNSKLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFG4</accession>
    <name>C4YFG4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Histone deacetylase interacting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_01281</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFG4"/>
    <dbReference type="PaxDb" id="5476-C4YFG4"/>
    <dbReference type="HOGENOM" id="CLU_001360_2_2_1"/>
    <dbReference type="OMA" id="MCEEVIK"/>
    <dbReference type="OrthoDB" id="10265969at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000002">
        <property type="entry name" value="Paired amphipathic helix protein SIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000003">
        <property type="entry name" value="Paired amphipathic helix SIN3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="7">
        <location>
            <begin position="334"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="627"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="627"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="999" mass="114899" checksum="5FA7A64262D3E5FF" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFW8</accession>
    <name>C4YFW8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_01356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_068488_0_0_1"/>
    <dbReference type="OMA" id="YYAYSHY"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="182" mass="21233" checksum="3B887463E6C31711" modified="2009-07-28" version="1">MDKIKEEMLPLALAIVRHKQSIDKTVLLDNIDPEIIARLADLGIDYYAYSHYNLTTIIHIIKYFLVRGSTDHHSHITHALLNRIRPGEFTPYLQQFTLDCLSILQSTPHSAPKLLWFYHFLLKFNHTQVGRFCIKNMYNNTNLLVLFYLKVLTTINYSPQQVKTILIAHNNPVILHISMNFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG20</accession>
    <name>C4YG20_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_00135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YG20"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00135"/>
    <dbReference type="HOGENOM" id="CLU_067895_1_0_1"/>
    <dbReference type="OMA" id="SQKKAHN"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11395">
        <property type="entry name" value="bHLHzip_SREBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Carbohydrate metabolism regulator TYE7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF3">
        <property type="entry name" value="SERINE-RICH PROTEIN TYE7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="171"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ41944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="267" mass="30297" checksum="9D6D57BB967A3E37" modified="2009-07-28" version="1">MSSFQQENQLNANNNNVMNEYISYSVPLSPVTTNENPQDYWMNGLIANSVPISQTTSNSDINYSQPPNPINFNSIFEGVNIFSNDDFTSSSNDISLANSPETNATSDSIAQNLDEVKVKLENHNQARLDALEFAFETKSILKEQPKIKQEPGTKAATKPKRRAPRKKLTESQKKAHNKIEKRYRININAKIAGIQKIIPWVAFEKTAFETGEENETEAEAKNNTRLNKSMILEKATEYILHLQKKEEEYMAENQKLREQVIKLGGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGL6</accession>
    <name>C4YGL6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_03195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGL6"/>
    <dbReference type="PaxDb" id="5476-C4YGL6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03195"/>
    <dbReference type="HOGENOM" id="CLU_940073_0_0_1"/>
    <dbReference type="OMA" id="YYSTSIC"/>
    <dbReference type="OrthoDB" id="4025955at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946462" evidence="2">
        <location>
            <begin position="19"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="296" mass="30458" checksum="0822EDDD353B4945" modified="2009-07-28" version="1">MKFTIVLFTLISVTVVAAATTTTTAAANRIQNKAYAYYYCNSYCTQAVNDENSCGYYDTDVSNQEYYACLCTKSSYYNNLRSCDCFTKVVYYYSTSICSRANVGTYVGGRTSTTWGVSATKYRSSTSTSSLTRKSSSIGASPSIAIASSTKESSSTESSSSLEQSSSAGQSSSTEQSPSTEVSSSSSIEESSSNQDISSTDSITTTSSDSSTGNTDSPTQGGGGNSGNNGSNGDGGNDASGGGGVVNENEQASSPPSSQSSTNSNQPNSSQTAPGAANYLSSVSVGTFMILVLGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGM1</accession>
    <name>C4YGM1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Exocyst complex component Sec3 PIP2-binding N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_03201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGM1"/>
    <dbReference type="PaxDb" id="5476-C4YGM1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03201"/>
    <dbReference type="HOGENOM" id="CLU_353727_0_0_1"/>
    <dbReference type="OMA" id="YSHELDT"/>
    <dbReference type="OrthoDB" id="27109at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13315">
        <property type="entry name" value="PH_Sec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01313">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="2">
        <location>
            <begin position="158"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="790" mass="88140" checksum="C400B3444E5E5AE5" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGR0</accession>
    <name>C4YGR0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_03242</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGR0"/>
    <dbReference type="PaxDb" id="5476-C4YGR0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03242"/>
    <dbReference type="HOGENOM" id="CLU_025145_3_1_1"/>
    <dbReference type="OMA" id="DMKIESF"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000028">
        <property type="entry name" value="DnaJ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052814">
        <property type="entry name" value="Peroxisomal_DnaJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006:SF1">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ44942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="459" mass="52482" checksum="13C0F8C036F5DD4F" modified="2009-07-28" version="1">MVKDTTYYDILQVEVTATDVELKKAYRKQAIKLHPDKNANDPKAAEKFQELGEAYGILSNPESRKIYDEFGVEGMKENPTMQQAADIDPAEFFNMIFGGDSFKQWIGELSMLNDMSRMGEIITEDEVELDNVEEESKSGKQHGATNALNESVQTLTISDNNNNNNTKVSSSNNKPTSNLTSEEIKKLKKQKINEQQREQMLKYQEEAKQAKLKRIDDLTSALLKRIENYQLSKNNKEALDSFTRKLQTEFEDMKIESFGIQLLHLIGKIYIDKANATIHASKTFGVSKIFTSVNQRQNSQNVSILKTAVDAQLSIEQMVKEQEQFLLAQEEGHQPTQEELVKQAEMERIITGKFLATAWATTKFEVTDILRKVCHNVLRDKTISKKERVARAEALLYIGKEMSKVERSPEEEEEARIFEEMMAEAQAKKSSKKQKSMNNKELEEYMKKMAAENAEAEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH16</accession>
    <name>C4YH16_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_03357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ45048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="110" mass="12993" checksum="5658B5C5869F6761" modified="2009-07-28" version="1">MHQVLSALFTFSLNRENSNNLCIYGTHNAIIPHHFFRLVRTRITWVLDEIHCCLKPSYCRFVNDINEIDAALAKVLYKMEKQKICLTGCYYVVWSYCSEHTRQFLVLFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH46</accession>
    <name>C4YH46_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_03387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
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                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YH46"/>
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    <dbReference type="HOGENOM" id="CLU_993955_0_0_1"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
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        <location>
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            <end position="224"/>
        </location>
    </feature>
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        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ45078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="32467" checksum="6BDD30E7133E948E" modified="2009-07-28" version="1">MSNIYLYKLASMIQQSTNSSDETESVSKQPQHQHHISPMNQLQSLNKEEVGKKSSKTDHIKQYIFKTVENMPTPKLMWLISPIAIVIYSTAFNIASEVLYSKFTYNSYGISFFKIAVLFLDVFIFLVVIYEQFYFTNDVHFTNKWSKYTYILICKILKKILWIILLIACVFQVIVISTGRLNNPLNIDNDYMQYFEMTPNEKTTYFIINLFSLIFNGAVLTIWWSTNISSVHSLFGLINLINILIGISISQINIVHIHNSHGANRRLHNWFIITGSFMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHE6</accession>
    <name>C4YHE6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_03492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHE6"/>
    <dbReference type="PaxDb" id="5476-C4YHE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03492"/>
    <dbReference type="HOGENOM" id="CLU_346116_0_0_1"/>
    <dbReference type="OMA" id="NFLMSPN"/>
    <dbReference type="OrthoDB" id="5367584at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="780"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="372"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="442"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ45178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="810" mass="93804" checksum="F20D66ACCB5EA601" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHN3</accession>
    <name>C4YHN3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_03581</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
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                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
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        <property type="protein sequence ID" value="EEQ45265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHN3"/>
    <dbReference type="PaxDb" id="5476-C4YHN3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03581"/>
    <dbReference type="HOGENOM" id="CLU_048602_1_2_1"/>
    <dbReference type="OMA" id="SCPVDHK"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="69"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ45265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="251" mass="28638" checksum="D30A3BDE6BC1183C" modified="2010-10-05" version="1">MSDSEQPKCPVDHSTRSSWLSKLTGDKKEQPKAAPPPVSEEPSCPVDHNARSVWANSVSVQVTAPEAIETTGTCDSSKIPNTLEDTTTTNIDLPGERELSSIPRTSSNTNWIYPSQKQFFEAMKRKNWDPQQEDMKVIVPIHNLVNERAWKHILMWEKPYAEDTQQKCGGITLTSFKGDSKKLTPRAWLKSIFGYDKPFDRHDWLINRCGVEVEYVIDFYTGQNSQVYLDVRPKLNTLEGIKMRFGRPFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHU8</accession>
    <name>C4YHU8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHU8"/>
    <dbReference type="PaxDb" id="5476-C4YHU8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03651"/>
    <dbReference type="HOGENOM" id="CLU_2183570_0_0_1"/>
    <dbReference type="OMA" id="STNIQWK"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946664" evidence="1">
        <location>
            <begin position="20"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="109" mass="11511" checksum="35ACBD39AFD956A7" modified="2009-07-28" version="1">MKSIAIITILQVLFTQIKAIAIDERGVGIANDDDQQPKGAPIGATSQFDPYSNISPLSVNNTTTATTLSTTKMSMTSSNTITGATGSTNIQWKLLLGCFLFAIVSLLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHZ8</accession>
    <name>C4YHZ8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translation machinery-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_03704</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with the 40S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DENR family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHZ8"/>
    <dbReference type="PaxDb" id="5476-C4YHZ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03704"/>
    <dbReference type="HOGENOM" id="CLU_073511_0_1_1"/>
    <dbReference type="OMA" id="EVFEIDM"/>
    <dbReference type="OrthoDB" id="277199at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11607">
        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="6">
        <location>
            <begin position="140"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="50"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ45380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="244" mass="27267" checksum="2CC39C808816568D" modified="2009-07-28" version="1">MTDIEPKSILYCGICSWPPEFCEFGITKKKCQTWLNENHPDLYQSVYPTAGNLSTANTPDESNKKSKPNTTDEKDITGETTGGEDGSNDDIVTKKLLEKGVSELSISKEEKLQQELNKRAAKEELKLERKQLEKISNSKIIIKKISRNKKKSIVSISGLEILETTAGTTGTTNNKVSIKSLQKKFSSKFATGTSVVKNAENKSDILIQGDVFEEVHQFIINLLQEQGLNDIKIELTDDKLKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIG2</accession>
    <name>C4YIG2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial 37S ribosomal protein MRP51</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIG2"/>
    <dbReference type="PaxDb" id="5476-C4YIG2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04236"/>
    <dbReference type="HOGENOM" id="CLU_063080_1_0_1"/>
    <dbReference type="OMA" id="KNAPGKH"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016712">
        <property type="entry name" value="Rbsml_bS1m-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11709">
        <property type="entry name" value="Mit_ribos_Mrp51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018156">
        <property type="entry name" value="MRPL51_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="41149" checksum="B44D20D41796ADDA" modified="2009-07-28" version="1">MSGSSSELFNLVKNSRLAQVAKPLSNNIRGNSKTPTHQVIFTPKSSALRSDYGLKSTLPNKIGSSHISFNDIDNRQSMPDVEKNSGFHYKQLMFQELGLCIKTHFTNKNPLFYHENNKSNKPMKDGSLTNTLNLPTKVQISEINKILKKNPQIYKEFRQYLIENHPNILLSSSSSSSSSSSSSTTTTTTNSSQSEIIDALKKFLSTSSKISKKKVNLFTTHKIDPKFQQNQIQGTGGFSYNQKGRLRNTPNGIKYGTVVPGRIIANKEAAIMGFVASVTDRSITLQSNYAKNAPGKHHRQFTVPFKINEAELGEDGSIRFFAEGIKTGKWMKANDNRYVPTKTNFASSSERNKADGKSLESLLNLILPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIU1</accession>
    <name>C4YIU1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04369</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ46026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIU1"/>
    <dbReference type="SMR" id="C4YIU1"/>
    <dbReference type="PaxDb" id="5476-C4YIU1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04369"/>
    <dbReference type="HOGENOM" id="CLU_089470_4_0_1"/>
    <dbReference type="OMA" id="IIWDDDV"/>
    <dbReference type="OrthoDB" id="277888at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000065">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052405">
        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203">
        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="35"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ46026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="171" mass="19644" checksum="ACD5727B6CF89CEB" modified="2010-10-05" version="1">MSSRINLFRSLFTSNSLKYGIPKKNKLPPRPKHLIKEEDIEEKFLHGGRGPGGQKINKTNSKVQLTHIPTGMVVSCQATRSQEQNRAIAREKLALKLDDFYNPGTSRNAVLMERAQKVKQSKSKKSNRKYKKVEDENIQKQMELSKLEESLNIKDIDDEFDDFIKNAKVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIW2</accession>
    <name>C4YIW2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_04391</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ46047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIW2"/>
    <dbReference type="PaxDb" id="5476-C4YIW2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04391"/>
    <dbReference type="HOGENOM" id="CLU_015166_10_3_1"/>
    <dbReference type="OMA" id="MYVCYGA"/>
    <dbReference type="OrthoDB" id="18574at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000272">
        <property type="entry name" value="Mitochondrial thiamine pyrophosphate transporter, mitochondrial carrier family member, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="15"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="115"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="206"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ46047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="301" mass="33098" checksum="E6BA5060D9B3B5FC" modified="2009-07-28" version="1">MSTKREDHLRKGADVTPTEALVAGSIAGAISRAFTAPLDTIKIRLQLQPKGFKHRKSVVTIVKNLLENEGIIALWKGNVPAEILYILYGGVQFGSYSIISKSVSKLENNYRINLSSANHSLIVGIGSGIVSTLVTYPFDLLRTRLIANKNRGLLSMTGTIKDIIKLEGIRGIYAGIRPAMLSVSSTTGLMFWSYELARELSNNYQRVPLIEAICGFIAGATSKGITFPLDTLRKRCQMCSVVHGRPYTASHIFVTILKNEGVFGLYKGFGISVLKTAPTSAISLFMYEYSLSFIRKIRVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ61</accession>
    <name>C4YJ61_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_03873</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
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                <person name="Silverstein K.A."/>
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                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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            <strain evidence="4 5">WO-1</strain>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10297"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ45613.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
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    </evidence>
    <sequence length="838" mass="90087" checksum="598AB1E3826AF16C" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJG7</accession>
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    </protein>
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            <taxon>Saccharomycotina</taxon>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        <text evidence="1 8">Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="10">
        <location>
            <begin position="14"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="379"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="696"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="426"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="713"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="732"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ45651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="791" mass="91595" checksum="0AA3DAB075A26FBB" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJL2</accession>
    <name>C4YJL2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_04029</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJL2"/>
    <dbReference type="PaxDb" id="5476-C4YJL2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04029"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_5_1"/>
    <dbReference type="OMA" id="SYRWRWI"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="24"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ45696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="503" mass="55362" checksum="74ED9A0228C9F7E8" modified="2009-07-28" version="1">MPNPTSIHNFLDKRHSITPLLGWSTFIICLSALQFGYHLAELNAPADVLSCNVKKPGPLPSYNNTIWSHFHFNQCINMTEQGVTLITTMFTIGGLLASIILGTTSISTNYGRKHLCVVAALFYVSGSFLMSFSQTNWQINLGRLLNGFGAGSSLIVSPILINELAPLNHRGLLGSLMQSAVSIGIFIAQIVSYFYSNDQQWRLIFLVAGLIGSVQFVGLLTVPESPKWLTMAKNDVERATLILKGFRTDESTVDYEIRHWGNLTTSNLPDDETSSLLSDDSLSSQNPPSIPTKDFIMERKYRKQLIAVVLIMTGQQLVGINAITYYGVKILNELFSGSNTGNLVLMLNCVFSGMNVAASIAVAPLIDRWGRKPLLMTSITMCAICTSILAIGIPNRYDIAVVTACIGFVTGWALGLGPLPFLMISEFTGHDVVATAQSLGTVMNWSSNMFIAMLFPFLTNILGIGMVFWVFVINSLVYGFGFYHYVPETKGFTHSRDVWEHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJL4</accession>
    <name>C4YJL4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RRN7-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_04031</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRN7/TAF1B family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJL4"/>
    <dbReference type="PaxDb" id="5476-C4YJL4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04031"/>
    <dbReference type="HOGENOM" id="CLU_016553_3_0_1"/>
    <dbReference type="OMA" id="TICQFGH"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048540">
        <property type="entry name" value="Rrn7_cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033599">
        <property type="entry name" value="TAF1B/Rrn7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021752">
        <property type="entry name" value="TF_Rrn7_Zf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576:SF2">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20644">
        <property type="entry name" value="Rrn7_cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11781">
        <property type="entry name" value="Zn_ribbon_RRN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRN7-type" evidence="10">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Rrn7/TAF1B N-terminal cyclin" evidence="11">
        <location>
            <begin position="145"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ45698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="50702" checksum="3A05A27F017E2025" modified="2009-07-28" version="1">MSRQDWFNGPVCGTDNCRSRLYRNQDGLTICQFGHVLEGAVEYNDDPDAGGIVQTRRLNTISFDERGHLSSAVVSNSQTIKTKSNRLYGEDAMALYYRCLQILLKKELKIFIDLFFSEGIRHDLMLIVKNNWVKLLSTDELQENHPKRQVIDTLDLICMIYISALQLQAYPIYIPDLIDNIKLNTIPYIRTLHLIPKHMLDQLPTVYHNRLQPYSLPENSQIYKRLQTTGWRTVGATLRIPTSFYFPFIFRILSEHFLLVNAVDLFVSAFNVLKSTSSFEINFRIKKFIQKFPEIYISSVLIILIRENFRSNDNLKPWLYELNKYELNNEYNSGGTSLLNWSDDKVDKYCDWIYDNLIPKKAKLNDDNTEALNTMEKRLFQIFSLDNDIENTAPETNETPMYLALRSIMNGSELKESGGLQELDTKLDAKLSNILGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJL9</accession>
    <name>C4YJL9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_04037</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJL9"/>
    <dbReference type="PaxDb" id="5476-C4YJL9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04037"/>
    <dbReference type="HOGENOM" id="CLU_036368_4_0_1"/>
    <dbReference type="OMA" id="LSMFKHA"/>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000143">
        <property type="entry name" value="Phosphoserine phosphatase serb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF2">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01137">
        <property type="entry name" value="C1.6.1:_Phosphoserine_Phosphat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01136">
        <property type="entry name" value="C1.6:_Phosphoserine_Phosphatas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00029">
        <property type="entry name" value="phosphoserine_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ45703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="301" mass="33321" checksum="679A34A991DDAF1D" modified="2009-07-28" version="1">MTYVLTAISHNDSKFETETLDSIKEFISNNFTLVSSKELSPRAIDYVISINDFESSKENVKEFSISKSFDLVIQLESTRKTKKLFIFDMDSTLIYQEVIELIASYADIEDKVAEITTRAMNGELDFNQSLAERVLLLKGIDASSIWDELKLKIQVTNGVPELCKALKKLNIIMGVCSGGFIPLAEFLKEKLGLDYAFANTLGIDDSNRLNGTTVGPIVNGEKKAELLLDIAKKHKIDPSDAVAVGDGANDLKMMSVAGFGIAWNAKPKVQKQAPACLNTKSLSDILYIMGYNDKEIKELID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJS9</accession>
    <name>C4YJS9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_04099</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YJS9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04099"/>
    <dbReference type="HOGENOM" id="CLU_000835_0_0_1"/>
    <dbReference type="OMA" id="KIEHGSF"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097308">
        <property type="term" value="P:cellular response to farnesol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900445">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000679">
        <property type="entry name" value="Peroxide stress-activated histidine kinase mak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25503">
        <property type="entry name" value="TPR_CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="358"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="2004"/>
            <end position="2225"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="14">
        <location>
            <begin position="2340"/>
            <end position="2466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="10">
        <location>
            <position position="2394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ45763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="2471" mass="281733" checksum="3B09ADA45D4A63A8" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJX6</accession>
    <name>C4YJX6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJX6"/>
    <dbReference type="PaxDb" id="5476-C4YJX6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05768"/>
    <dbReference type="HOGENOM" id="CLU_2910221_0_0_1"/>
    <dbReference type="OrthoDB" id="4014227at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ47205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="62" mass="6894" checksum="FBC3F22A440DEB36" modified="2009-07-28" version="1" fragment="single">MMSRKASRNPKLYVSALIATSAIALTYKLYSTYLAPTPTSTNKDKKQRELDGSSTDIELKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK34</accession>
    <name>C4YK34_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein kinase TOR</fullName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_05829</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YK34"/>
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    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:protein-containing complex binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of macroautophagy"/>
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    </dbReference>
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        <property type="term" value="P:regulation of primary metabolic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:TORC1 signaling"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
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    </dbReference>
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        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000748">
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    </dbReference>
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        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
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    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
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        <property type="entry name" value="DDR_Repair_Kinase"/>
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        <property type="entry name" value="FRB_dom"/>
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        <property type="entry name" value="mTOR_dom"/>
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        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
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        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
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        <property type="entry name" value="PIK-rel_kinase_FAT"/>
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        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
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        <property type="entry name" value="TOR_cat"/>
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    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
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    </dbReference>
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        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF3385"/>
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        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="13">
        <location>
            <begin position="629"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="12">
        <location>
            <begin position="1397"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="14">
        <location>
            <begin position="1742"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1074"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1074"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1096"/>
            <end position="1108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ47263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1774" mass="202374" checksum="A2A6E4740AC573B6" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK51</accession>
    <name>C4YK51_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_05847</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="DYMNMVI"/>
    <dbReference type="OrthoDB" id="786951at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039249">
        <property type="entry name" value="GPATCH11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF0">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="3">
        <location>
            <begin position="81"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ47280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="271" mass="31147" checksum="41090DD75713E81D" modified="2009-07-28" version="1">MKKRLVLFDDSDDNSETESDKSKLKSRKKQFKIPEYPQPPSFPVNEQNEDYMKYQLEDDKHEEPTESAIDRKDRSLFSDPSTSIGLSIMERMGFKIGNALGNSATAIKEPIEVFLKSGRQGLGGGFKPLQYKQEDVENLKLNLANSNKQRIELRDLKKIMKLCFELSGEYDKYLEGEDITEVNSLWQPYVKIYVSKQQSAAVGSVKATFNAVETLQLFEREVENTEQTLSDLLNYLRGTHNYCWYCGLKYNDQNDLLANCPGKTRDIHLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK59</accession>
    <name>C4YK59_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_05855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK59"/>
    <dbReference type="SMR" id="C4YK59"/>
    <dbReference type="PaxDb" id="5476-C4YK59"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05855"/>
    <dbReference type="HOGENOM" id="CLU_125101_2_1_1"/>
    <dbReference type="OMA" id="ARKYRQD"/>
    <dbReference type="OrthoDB" id="250802at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2950:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF11">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="27"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ47288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="113" mass="12818" checksum="59F9345371EDC5B5" modified="2010-10-05" version="1">MSSGIQSLLKTEKEAAEIVNEARKYRTTRLKSAKQDAQAEIDNYKKQKEEELKNFEKEHEGLNEKIDKEADAEVEKELTSIKSTFEKKKSAVVKLLVDATVKPTPTLHINASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKF7</accession>
    <name>C4YKF7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKF7"/>
    <dbReference type="PaxDb" id="5476-C4YKF7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05959"/>
    <dbReference type="HOGENOM" id="CLU_1137870_0_0_1"/>
    <dbReference type="OMA" id="FTKWARH"/>
    <dbReference type="OrthoDB" id="4019505at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ47386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="232" mass="26924" checksum="881A8E8F57EE24E9" modified="2009-07-28" version="1">MDSNQPIMPKINSPLGILRTSQAVASDITINIILYALIYSIIYLFRLRNLFLQFNHYFITIILFILEIFWIILYIIIRLIYLVYNTINDSKINDYRYNTHGILRTFIIHNQFWKFKNNLVMNSIFKHGPNVFLDIQDDLIIPNLINKGNDIIIPIDNNDNINDIDIDHDNDNDDDESSLTSNISNSTRIKTKSNFTKWARHSQFASTPPPLLSSSNSAGSLNKLKSKIYPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKG2</accession>
    <name>C4YKG2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="4">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_05965</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TOP6A family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKG2"/>
    <dbReference type="SMR" id="C4YKG2"/>
    <dbReference type="PaxDb" id="5476-C4YKG2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05965"/>
    <dbReference type="HOGENOM" id="CLU_037229_2_0_1"/>
    <dbReference type="OMA" id="YICTMAN"/>
    <dbReference type="OrthoDB" id="5377392at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
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    </dbReference>
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    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Spo11/DNA topoisomerase VI subunit A N-terminal" evidence="10">
        <location>
            <begin position="35"/>
            <end position="85"/>
        </location>
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    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="11">
        <location>
            <begin position="147"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ47391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="309" mass="36094" checksum="A4AE89D43D75379C" modified="2009-07-28" version="1">MNYHEVTIIIKNSSNNSLRKLGSYCVLSIRETETRRFAAVCKLISILIKHLKAQNQITTIRDIYYQDVEVFNHCQNECRFLLGQLVERGLGWSLCDDLNIHPTQKGLVYGDYFQELSIKAEPILIPINYTKFFNTKITQIKVEKVIVVILEKDAVFQCLCTHLRQHNIINRFLIVTAKGYSDNLTLRFLTWLQTNENCKFIGFFDSDVYGLNIYWQYNQKLPEMVYSGIYLLESQPHTWLSITLRDIAMMIKICKNGNNKYNDIPYRELTRGLYLFKKAEMNVVQANNANQSYVNYMVSKILGTPSYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKH7</accession>
    <name>C4YKH7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKH7"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05981"/>
    <dbReference type="HOGENOM" id="CLU_006027_0_0_1"/>
    <dbReference type="OMA" id="KMNEECD"/>
    <dbReference type="OrthoDB" id="4026032at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946568" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ47406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1277" mass="130033" checksum="1731FD8AFF774D24" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKJ3</accession>
    <name>C4YKJ3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H2 subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribonuclease HI subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_05997</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKJ3"/>
    <dbReference type="PaxDb" id="5476-C4YKJ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05997"/>
    <dbReference type="HOGENOM" id="CLU_075897_0_0_1"/>
    <dbReference type="OMA" id="EYREDTN"/>
    <dbReference type="OrthoDB" id="29098at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040456">
        <property type="entry name" value="RNase_H2_suB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019024">
        <property type="entry name" value="RNase_H2_suB_wHTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041195">
        <property type="entry name" value="Rnh202_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383:SF11">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09468">
        <property type="entry name" value="RNase_H2-Ydr279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17745">
        <property type="entry name" value="Ydr279_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rnh202 triple barrel" evidence="8">
        <location>
            <begin position="9"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease H2 subunit B wHTH" evidence="7">
        <location>
            <begin position="118"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="318"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019062"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024778"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00033464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ47422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="354" mass="40638" checksum="8908DA81A3E176DD" modified="2009-07-28" version="1">MDKESKVIILPKTNSSSEFKIINLPNPTNLTTTKSYLLHHNEDSNNQLYELNIIGGEDDTGADDDEKTDNDNTGRKNKGKKPKSKLKSENSIKSLVFEPGYVLQSPKIIISNKFNLSYLLISLFSNLNQQKSQQQSQQSSLSSENLFNDNFKSLEDLKDQLLNEYREDTNNNDWVLEIPDQLYHQSLINLCDVITENIDESFYRFDLSKILHWLNGKVLALQKYILTSDNSILTKLKLELNPSMSNNNIEDQLLNDLSLLYSIDYIFNSYLDDGVNSFLRQKLLEEFKYDFTRVLKHIDDLKIHQSLIENVLESNLKSTTNNTKSSSTKKKPATGTTNKKVKRGAIDSFFKKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKJ4</accession>
    <name>C4YKJ4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Stress protein DDR48</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKJ4"/>
    <dbReference type="PaxDb" id="5476-C4YKJ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05999"/>
    <dbReference type="HOGENOM" id="CLU_114213_0_0_1"/>
    <dbReference type="OMA" id="DSMVDQK"/>
    <dbReference type="OrthoDB" id="4026468at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="20904" checksum="48779BE9AFD48EB0" modified="2009-07-28" version="1">MVFGFGKDDDKDKNDRRDNDSYGSSNRRNNDDSYGSSSFGSSNDDDNSYGSSNKRGNDSYGSSNTDSYGSSNRRDNDSYGSSNTDSYGSSKTDSYGSSNRSGNDSYGSSNNDSYGSSNRKGNDSYGSSNTDSYGSSNADSYGSSNKRGNDSYGSSNDDSYGSSNRRGNDSYGSSNDDSYGSSNRRGNSDSYGSSDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL43</accession>
    <name>C4YL43_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_01558</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL43"/>
    <dbReference type="PaxDb" id="5476-C4YL43"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01558"/>
    <dbReference type="HOGENOM" id="CLU_956448_0_0_1"/>
    <dbReference type="OMA" id="WIDIKRE"/>
    <dbReference type="OrthoDB" id="2687452at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="111"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="18"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ43324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="250" mass="29208" checksum="BD5769C6F4A5C92A" modified="2009-07-28" version="1">MVKQKQKRIKFEEELGQPILQTKTTSPLPNVSNINRQETQPFNAYTTYQAPSQESEYRHQEQKSIEETAPSSSRIQTQLDSQVLRRSSPPVIVFRRDKPKKVLPKKPVKPYLCTHPGCTWAFARHSDLTRHSKSHAEPQYKCPYWKNDPTCHKKNGAFNRLDVLKRHLRLIHYVKDKQPISDLNPGQDPGWCRACQRIFPNSKAFIEHCYDCAKNTVPTEWIDIKRESSRIPNQTTFRVKLDQINNTENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLB9</accession>
    <name>C4YLB9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="8">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_01637</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="8"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLB9"/>
    <dbReference type="PaxDb" id="5476-C4YLB9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01637"/>
    <dbReference type="HOGENOM" id="CLU_070631_1_0_1"/>
    <dbReference type="OMA" id="PCRTCNT"/>
    <dbReference type="OrthoDB" id="17199at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000003">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF0">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="10">
        <location>
            <begin position="93"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ43400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="201" mass="23066" checksum="3DD507CB047E9A93" modified="2009-07-28" version="1">MSTTETTEKAESNSKPEVGFTGRKIVYDKDGKVSNYFGCLIKGVLLTNIQFRCRTCNSLLDFQFASGKIKKSPVTPESKKVNKPELKSYPQDEPPDVTELGKSSWTLLHSIAATYPETPTTKQQSDMKSLINLFSGFYPCWFCAEDFQKYIAKNEPKTGNQEELGRWLCDAHNEVNKKLNKPQFNCDLWKKRWKDGWDNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLL3</accession>
    <name>C4YLL3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome-recycling factor, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribosome-releasing factor, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_01732</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLL3"/>
    <dbReference type="SMR" id="C4YLL3"/>
    <dbReference type="PaxDb" id="5476-C4YLL3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01732"/>
    <dbReference type="HOGENOM" id="CLU_085410_0_0_1"/>
    <dbReference type="OMA" id="PNNDQQL"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="7">
        <location>
            <begin position="88"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="261" mass="29583" checksum="B14888B4BFB57885" modified="2010-10-05" version="1">MFRSVIAQQRFVLPRLAIHPRISRSILFCPSNSFHSSSQCLAKRKNKKSSNKNDEELDSSEKADENAEVTIDFQKVTSNFDNVLSKFNKAATDIKLGKLNPKIFDNLEVNIGNHGHEELVPFTSVAQTSVKGRNFIINLFDAGYGKHVINSIIGSGLNMSGTIDPTNKFQIKVPIPNITTETKQENIKQLKEIFENLKNNHKSNSLNYVRSEARNKFQSSLKHNKISDSQHQLLKKLETLHKTYVDKLTDAFKQAEKSILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLL4</accession>
    <name>C4YLL4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Vacuolar fusion protein MON1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_01733</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endosome</location>
            <location evidence="4">Multivesicular body membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 4">Prevacuolar compartment membrane</location>
            <topology evidence="1 4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Vacuole membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the MON1/SAND family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLL4"/>
    <dbReference type="PaxDb" id="5476-C4YLL4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01733"/>
    <dbReference type="HOGENOM" id="CLU_025637_0_0_1"/>
    <dbReference type="OMA" id="QQPFNAK"/>
    <dbReference type="OrthoDB" id="272411at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="6">
        <location>
            <begin position="142"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="7">
        <location>
            <begin position="324"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="8">
        <location>
            <begin position="453"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ43495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="565" mass="64449" checksum="C5E691EABB1513FE" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLT5</accession>
    <name>C4YLT5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLT5"/>
    <dbReference type="PaxDb" id="5476-C4YLT5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01804"/>
    <dbReference type="HOGENOM" id="CLU_136881_0_0_1"/>
    <dbReference type="OMA" id="KSIIIAY"/>
    <dbReference type="OrthoDB" id="10623272at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="133" mass="15701" checksum="B9DF528893ABD063" modified="2009-07-28" version="1">MESNNNKLKKKSIIIAYNEEDEDLEEEEFKIKSVYDLNKQESNDIDNNTNEIKQLDNTNIEHKEKKEEKEKEEEEEVSELKSEEEEEEDEEQVSFPKIINRDPSIDSDYDSDLDLNNSESISINQLKAHKYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLV0</accession>
    <name>C4YLV0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_01818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLV0"/>
    <dbReference type="PaxDb" id="5476-C4YLV0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01818"/>
    <dbReference type="HOGENOM" id="CLU_024390_0_0_1"/>
    <dbReference type="OrthoDB" id="4084239at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="250" mass="29377" checksum="3BD683B17151037D" modified="2009-07-28" version="1">MQAFFLSFVIKNENQNQNDKVPLLTNLKTLQLPDFFTSFIYYKPDFMESLLHTCKCWGCQLVLNKLENEFYDKLIDENLETNYYMTIGYILGKLQADREVCIPIKEKTFHYNKYPINKGQPHTLHNNFHIPNENENENEEEVDNHSLMTNCCQCNIINDPLGVDELNIDNLVTTYIIHQVDPIINYLNVMFINLDNLMIHGIYYERDPLIGKMIPIYDNSEYPQSFLMEAKDYIERGLNPPGPFGTFRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLW7</accession>
    <name>C4YLW7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_01839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLW7"/>
    <dbReference type="PaxDb" id="5476-C4YLW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01839"/>
    <dbReference type="HOGENOM" id="CLU_1834896_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="141" mass="16454" checksum="0AF2251750783CAF" modified="2009-07-28" version="1" fragment="single">KCTISPPPPLPLYDLLYLLLSSSQPNSIYLYIQIWGFSQNFTIPFFKLYTEIQPTESINVSNNQNKLSLICPTVNKKKRKIFLESFFRTCATTHLLFSYCIYVIKKEILILDIEFLVFLPFIIRKWTTGTKYNFYTGKTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLZ9</accession>
    <name>C4YLZ9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dipeptidyl aminopeptidase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_01874</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9B family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLZ9"/>
    <dbReference type="ESTHER" id="canal-q59m48">
        <property type="family name" value="DPP4N_Peptidase_S9"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.005"/>
    <dbReference type="PaxDb" id="5476-C4YLZ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01874"/>
    <dbReference type="HOGENOM" id="CLU_006105_0_1_1"/>
    <dbReference type="OMA" id="NYDMHIF"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF160">
        <property type="entry name" value="DIPEPTIDYL AMINOPEPTIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
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        <location>
            <begin position="236"/>
            <end position="616"/>
        </location>
    </feature>
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        <location>
            <begin position="724"/>
            <end position="923"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006150"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ43630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="937" mass="107828" checksum="6585FACFCFDFC5CC" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMB5</accession>
    <name>C4YMB5_CANAW</name>
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        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_01994</name>
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    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="GENTNFY"/>
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        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR039905">
        <property type="entry name" value="CD2BP2/Lin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138:SF3">
        <property type="entry name" value="CD2 ANTIGEN CYTOPLASMIC TAIL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138">
        <property type="entry name" value="PROTEIN LIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GYF"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="356"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
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            <begin position="39"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ43746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="414" mass="48716" checksum="70195C9905CCFA46" modified="2009-07-28" version="1">MNNQTDLFSNVGESTVNNSSRRRKRGANKNELQLTYESDSSDDQEGNSDNENNISKLQQQSEEDILGDNKENDMFDSDKEDDMFTNDNKQEEDDDDMFASDNEESDPQKNNLDDEEEEEEEEEIKETDESVNNYYNNIEDLNFDSFQNKKKEPKFEAFNLKEETNMGKFDNEGNYIPNEQKDSSDADDDDLWLEDYNNKSEINKAKQAQLLRERQQREKSKSKSMEKDHNVEPLEVLLSDLILLLEPVESPMEALARLNPKNLRKKKKKGDDDDNNKNGIANHEELINKITNVCSILINDKQIDDIYELTREELTRKFQTITGQSFNVERGLKRSREESDDEDDENSQINNIDYGEKIWEFRWIGDENEDKVINGPYSSYEMNHWKETYFENKVEVRKIGETKFQNIEYINEFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN52</accession>
    <name>C4YN52_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">CAWG_02292</name>
    </gene>
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        <name type="common">Yeast</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4023545at2759"/>
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        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946654" evidence="2">
        <location>
            <begin position="19"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="124" mass="11796" checksum="027F99F6EFC87206" modified="2010-10-05" version="1">MKFQFVTALALASTMAVAAPINDQQEVLGAVAATRSKREGGSTGAELQDNNQPTAGLFGDGNSFGNQGLGGFLAATVDSLTKTIASPIKGILAPGGGSGGNGGSGGSGAAGGVGNLFSGILGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNG4</accession>
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        <recommendedName>
            <fullName evidence="12">Subtilase-type proteinase RRT12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_01424</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
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                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
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                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="MEROPS" id="S08.A50"/>
    <dbReference type="PaxDb" id="5476-C4YNG4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01424"/>
    <dbReference type="HOGENOM" id="CLU_011263_1_0_1"/>
    <dbReference type="OMA" id="GRMGVAN"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF13">
        <property type="entry name" value="SUBTILASE-TYPE PROTEINASE RRT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944343" description="Subtilase-type proteinase RRT12" evidence="7">
        <location>
            <begin position="22"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="9">
        <location>
            <begin position="50"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="134"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ43197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="43562" checksum="8A705F73A4E63C32" modified="2009-07-28" version="1">MVKLLLSIWISIYFMAGSSFASSSYLVSLHSQETIDTFMAYDATYPQDLQVGELINSKFKIGNFSGFSGSFSKDIIKRLERCPLVDEIVPDITVKAYDAVFQDSAPRHLARISRRKRMKPIKKYSYIYESDFIGKKVSAYVIDSGIAIGHPEFQGRARTGKDFTDEGPGDNNGHGTHVAGLIGSHTYGVAKGVQIIDVKALNSKGTGSLSTILVAIEFAVNHRLRSGRMGVANLSLGAYKNKLLNKAIDQATQTGLVFVVAAGNNNINACLTSPSSSPYAITVGAIDDYNDSIASFSNWGECVDLFASGAYVKSVNIRSDFRPSVLSGTSMAAPIVTGLVANLLNEGVDPELIKGQLIEMSTKHRISKSSLFLKKRTPNRIAYNGICFSYYQDEEDCFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNJ1</accession>
    <name>C4YNJ1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAWG_01453</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YNJ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01453"/>
    <dbReference type="HOGENOM" id="CLU_003731_0_0_1"/>
    <dbReference type="OMA" id="WGDSNRI"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007234">
        <property type="term" value="P:osmosensory signaling via phosphorelay pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900445">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000155">
        <property type="entry name" value="Histidine kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000261">
        <property type="entry name" value="Histidine kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000289">
        <property type="entry name" value="Osmosensing histidine protein kinase SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 14" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="19">
        <location>
            <begin position="443"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="17">
        <location>
            <begin position="510"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="18">
        <location>
            <begin position="1247"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="387"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="673"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="841"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1080"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="405"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="679"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="703"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="715"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="747"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="761"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="887"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="903"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1104"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1199"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1223"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="14">
        <location>
            <position position="1302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEQ43224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1375" mass="150966" checksum="1DF3A4215CD08AE5" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNM3</accession>
    <name>C4YNM3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_01486</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNM3"/>
    <dbReference type="PaxDb" id="5476-C4YNM3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01486"/>
    <dbReference type="HOGENOM" id="CLU_008455_13_3_1"/>
    <dbReference type="OMA" id="RWCFWYL"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000224">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF34">
        <property type="entry name" value="PROTEIN HOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="59"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ43256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="548" mass="61224" checksum="A8D33F63C749A3B0" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNM9</accession>
    <name>C4YNM9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">homoisocitrate dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_01492</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2R,3S)-homoisocitrate + NAD(+) = 2-oxoadipate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:11900"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57499"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.87" evidence="12"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNM9"/>
    <dbReference type="PaxDb" id="5476-C4YNM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01492"/>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_1"/>
    <dbReference type="OMA" id="DSFVMGE"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047046">
        <property type="term" value="F:homoisocitrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000012">
        <property type="entry name" value="Homoisocitrate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF48">
        <property type="entry name" value="HOMOISOCITRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="13">
        <location>
            <begin position="23"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ43262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="376" mass="40674" checksum="C6EFDC0B1D0EA673" modified="2009-07-28" version="1">MLAARSSIRRCFSTSSTTLKSLKIGLISGDGIGREVIPAGKAVLENLPSKHDLQFEFVNLDAGFELFKKTGTALPDETVDVLKKECDGALFGAVSSPTTKVAGYSSPIVALRKKLGLYANVRPVKSVEGIGRPVDMVIVRENTEDLYIKEERVYKKEDGTKVAEAIKRITETASTRIAKMAYEIALQREAVRKGTSGKQLHEKPSVTVTHKSNVLSQSDGLFRETCRAVYDANANEYGGIEYKEQIVDSMVYRMFREPEIFDVVVAPNLYGDILSDGAAALVGSLGVVPSANVGDNFAIGEPCHGSAPDIEGKGISNPVATIRSTALMLEFMGYPEAAATIYQAVDANLAEDKIKTPDLGGNSTTQEVIDDIIRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNS8</accession>
    <name>C4YNS8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidant-induced cell-cycle arrest protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_02861</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OCA5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNS8"/>
    <dbReference type="PaxDb" id="5476-C4YNS8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02861"/>
    <dbReference type="HOGENOM" id="CLU_028055_0_0_1"/>
    <dbReference type="OMA" id="NWWLTLF"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="423"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="150"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="279"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="285"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ44587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="737" mass="86367" checksum="117CCED440D2E09D" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNY6</accession>
    <name>C4YNY6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_02919</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNY6"/>
    <dbReference type="SMR" id="C4YNY6"/>
    <dbReference type="PaxDb" id="5476-C4YNY6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02919"/>
    <dbReference type="HOGENOM" id="CLU_003041_16_3_1"/>
    <dbReference type="OMA" id="CYRSWVR"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901195">
        <property type="term" value="P:positive regulation of formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000160">
        <property type="entry name" value="ATP-dependent RNA helicase DDX3X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="217"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="417"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="583"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="48"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="608"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="621"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ44645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="672" mass="72839" checksum="D2C0FC1A9009ACE9" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP17</accession>
    <name>C4YP17_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_02952</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YP17"/>
    <dbReference type="SMR" id="C4YP17"/>
    <dbReference type="PaxDb" id="5476-C4YP17"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02952"/>
    <dbReference type="HOGENOM" id="CLU_052855_2_0_1"/>
    <dbReference type="OMA" id="WQFGIEI"/>
    <dbReference type="OrthoDB" id="67566at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000656">
        <property type="entry name" value="Oligosaccharyltransferase complex subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021149">
        <property type="entry name" value="OligosaccharylTrfase_OST3/OST6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692:SF3">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04756">
        <property type="entry name" value="OST3_OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946906" evidence="6">
        <location>
            <begin position="20"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ44676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="340" mass="38321" checksum="4237C580A697513B" modified="2010-10-05" version="1">MYIVNYIIGLLLYIEVALCSSHSAIRLTELAKESQDYIIDVYNSDLSILEGPRDYFTVLLFTSSNADHNCKQCEGFKNVVTKVANSWFSDHTDSHLLTFITIDLNDPKNGKLFSLIGLQTVPHIWLVAPNPSRDYGDPNKILEDAHLEFKMPQVSQDKQTLEFAQFISEQLQKPILIRDTDALTKFIKTFVITFSVIIIIRKKGPSRITATKKKTIVSLVAIAIVLLFTCGYQFTIQNSVPFVAKSNNGDIVLISGGQYYQFGIETFLVGANYASLAGALLLLTYIGCYKVTERSFITSEDIRVLLVLLVTILIYLLYSCLTSIVLRKDQGYPYSFIKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP96</accession>
    <name>C4YP96_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="9">1.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">D-lactate ferricytochrome C oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_03045</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the stereospecific oxidation of D-lactate to pyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="9"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YP96"/>
    <dbReference type="PaxDb" id="5476-C4YP96"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03045"/>
    <dbReference type="HOGENOM" id="CLU_017779_3_3_1"/>
    <dbReference type="OMA" id="LMFGTDC"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000038">
        <property type="entry name" value="D-lactate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF117">
        <property type="entry name" value="AER321WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="13">
        <location>
            <begin position="99"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ44755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="533" mass="58557" checksum="D3F8E5E4D32AAE9C" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-02-08" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPI7</accession>
    <name>LIS1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nuclear distribution protein PAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lissencephaly-1 homolog</fullName>
            <shortName evidence="1">LIS-1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">nudF homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">PAC1</name>
        <name evidence="1" type="synonym">LIS1</name>
        <name type="ORF">CAWG_02388</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Positively regulates the activity of the minus-end directed microtubule motor protein dynein. Plays a central role in positioning the mitotic spindle at the bud neck during cell division. Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein-mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates. Interacts with NDL1 and dynein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle pole</location>
        </subcellularLocation>
        <text evidence="1">Localizes to the plus ends of microtubules and the mitotic spindle poles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LIS1/nudF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPI7"/>
    <dbReference type="SMR" id="C4YPI7"/>
    <dbReference type="PaxDb" id="5476-C4YPI7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02388"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_15_1"/>
    <dbReference type="OMA" id="WHVATKE"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051012">
        <property type="term" value="P:microtubule sliding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000902">
        <property type="entry name" value="Nuclear distribution protein PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03141">
        <property type="entry name" value="lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017252">
        <property type="entry name" value="Dynein_regulator_LIS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037190">
        <property type="entry name" value="LIS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050349">
        <property type="entry name" value="WD_LIS1/nudF_dynein_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44129">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037647">
        <property type="entry name" value="Dynein_regulator_Lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109925">
        <property type="entry name" value="Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0493">Microtubule</keyword>
    <keyword id="KW-0498">Mitosis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000405072" description="Nuclear distribution protein PAC1">
        <location>
            <begin position="1"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="119"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="164"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3">
        <location>
            <begin position="206"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4">
        <location>
            <begin position="249"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5">
        <location>
            <begin position="294"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 6">
        <location>
            <begin position="329"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 7">
        <location>
            <begin position="389"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 8">
        <location>
            <begin position="437"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03141"/>
        </source>
    </evidence>
    <sequence length="486" mass="55358" checksum="166A0B449BF8A104" modified="2009-07-28" version="1">MEKLQILTERQQTELNHAIIQYLQPLCQQDNHVLLDQLSKLLNIDQSTQESNNVEKVDNYLEKRWSTVLRLQKKIIDLENEISNLNNIINSTNSDNNGIILSKDKINWIPKGAVKQSYQCENIVTTVKLHPNLPLVLNGCNDGNLYIWNISNDDNTIPEKMIKAHTRAINKICFTYKKPYYLATCSSDLTIKIWDEKFNHIRTLNGHEHTVSSIQFSPVDNSILYSVSRDKNIRVWDIFQGISLKSFVGHSEWCRDLDIISSDTYGDFVLTCSNDQSARLSHANSGAGVAMIVGHSHVVETVKFLPSLQANKILDEYITKNTEQFPTIPLELLKDKTYNQLGFKYCITASRDNTIKLWLIPPPTIAPHRPPLPSKYNNSQSWLIAELKGHSSWVKSLCVHPNGKFIISGSDDKTIKFWDLSGLLETGYVNVVKTIIGHDGFINDIDFARLKEASDVSEEDLLKQVEKRMRCLFISGSADNSIKLWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPJ1</accession>
    <name>C4YPJ1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="424"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ44130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="440" mass="49051" checksum="8D67E0FAAC7F610F" modified="2009-07-28" version="1">MGLLSSLLCCSIESKDDNDDKVHRPSTSNGIATTTSNKSNAAVTSASSKGNSSRNNQQDKAKKINTTTTKTTKANTTIKPTTNTSKSQSKNTPTRHGKDANSNENNSDLTKDNDIDVMGDEDEDEEDEVDALKPSKKDLLDDDQSINEIETIANTNDESNNNTPKSSNDTTKTDTNNTKINTSDIITQVPENGGAYTTTNSSNNYQKESRNSVQKNETRNGEDDDEEEEDEDDDEDDESLEDLTKLQDGQAFNPETGYLLGKKDKNFGNKKCLILDLDETLVHSSFKYLRNADFVIPVEIDNQIHHVYVVKRPGVDEFLQKMGKLYEVVVFTASVSKYGDPLLDKLDIYNSVHHRLFRDSCYNYQGNFIKNLSQIGRPLEDTIIIDNSPASYIFHPDHSIPISSWFSDSHDNELLDLIPFLEDLAKPIVDDVGLVLDISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPK8</accession>
    <name>C4YPK8_CANAW</name>
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        <recommendedName>
            <fullName evidence="4">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_02409</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="entry name" value="Pumilio"/>
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    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
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        <property type="entry name" value="PUMILIO HOMOLOGY DOMAIN FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="422"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="477"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="513"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
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            <end position="585"/>
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    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="603"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="640"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="685"/>
            <end position="722"/>
        </location>
    </feature>
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        <location>
            <begin position="724"/>
            <end position="759"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="12"/>
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    </feature>
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        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ44147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="783" mass="87112" checksum="A3DC63195EC2DD15" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPS0</accession>
    <name>C4YPS0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin cytoskeleton-regulatory complex protein END3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Actin cytoskeleton-regulatory complex protein end3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Endocytosis protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CAWG_02472</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the END3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPS0"/>
    <dbReference type="PaxDb" id="5476-C4YPS0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02472"/>
    <dbReference type="HOGENOM" id="CLU_040829_0_0_1"/>
    <dbReference type="OMA" id="DWLIPES"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025604">
        <property type="entry name" value="End3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12761">
        <property type="entry name" value="End3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="11" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EH" evidence="20">
        <location>
            <begin position="8"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="20">
        <location>
            <begin position="136"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EEQ44209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="396" mass="44926" checksum="0CE0F0800C24BFD3" modified="2009-07-28" version="1">MPRLEESEIKKYWQIFQSLKPQNNKLTGDQLSSILKNSQLPQQQLSAIWELSDIDNDGKLDFEEFCIIMRLIFDVINGKLPNVPQELPSWLIPASKSAIIQANKAVNQGNNNFGGIDDDEDDKLSNDFDWYISPTDKSIYEKIYDSKCDSFGRIKYSSLNELYNGLTNVPSSEISSAWNLINPKSFETIDKDQTLVFLHILNQRENGKRIPRGVPASLRATFSKEVPNYDLSAQAKPSISATTETGKKSFAENYLNKIGGGGGGGSSTINNGRNEKGTDFSATQGTDWEEVRLRRELQDLERLLDKVQNDTKNQKDNSNNNQDNNDMLIKYEFEQLLKYKQNQLNSTTNASKNSTDLSSVKQDIEEIQNQVNTLQEFLTTKNQELLKLNQQIESLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPS5</accession>
    <name>C4YPS5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_02477</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="10"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPS5"/>
    <dbReference type="SMR" id="C4YPS5"/>
    <dbReference type="PaxDb" id="5476-C4YPS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02477"/>
    <dbReference type="HOGENOM" id="CLU_031026_1_1_1"/>
    <dbReference type="OMA" id="YAYESHQ"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF8">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="15">
        <location>
            <begin position="15"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="16">
        <location>
            <begin position="290"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ44214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="410" mass="43877" checksum="65CBEC99E39E4692" modified="2010-10-05" version="1">MSSKQQYLKKNPDDVVVVAAYRTALTKGGRGGFKDVGSDFLLKKLTEEFVKKTGVDPKIIQDAAIGNVLNRRAGDFEHRGALLSAGLPYSVPFVALNRQCSSGLMAISQVANKIKTGEIECGLAGGVESMTKNYGPEALIAIDPAYEKDPEFVKNGIPMGITNENVCAKFNISRDVQDQFAAESYQKAEKAQKEGKFDDEILPIEVFQEDEDAEDEDEDEDEDAEPKEKLVVISKDEGIRPGVTKEKLAKIKPAFKSDGVSSAGNSSQVSDGAALVLLMKRSFAEKNGFKPLAKYISCGVAGVPPEIMGIGPAVAIPKVLKQTGLSVSDIDIYEINEAFAGQCLYSIESCNIPREKVNLNGGAIALGHPLGCTGARQYATILRLLKPGEFGVTSMCIGTGMGAASVLVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPU5</accession>
    <name>C4YPU5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPU5"/>
    <dbReference type="PaxDb" id="5476-C4YPU5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02499"/>
    <dbReference type="HOGENOM" id="CLU_043838_0_0_1"/>
    <dbReference type="OMA" id="PFFYLAY"/>
    <dbReference type="OrthoDB" id="5562676at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018786">
        <property type="entry name" value="Mit_KHE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062">
        <property type="entry name" value="K+-H+ EXCHANGE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10173">
        <property type="entry name" value="Mit_KHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="369" mass="42037" checksum="62E689B40C18BDF3" modified="2009-07-28" version="1">MITTRSIQKYHSLYRPSIITCRRFQSSRSTTTTTTTATTPISQLPNKNSIYVISIPITTSKSYIYCNHRPSTLSPKQLANIPLIYKLENKLINLASKGWSKLTNSKQSVNQKVVSFIKKLLDTIPYEENCLKSFPTKATMIREINEESSHFTEGNKDQSGSDSSGQMPVHKIVQAQVDDLKISTDQLKPIPLYHPQFQNPSVILNQLYSFEEENKKKHKNQAILCAIGIPITLPFALVPILPNVPGFYLAYRLYCNIKALLGLQHLNYLLETKKGGDPEIANQSTVNDTLHITFKEIEGLNQLYLQHNNPNLLQDPIEDDEETVIINEDIINQIVEKFELTNLKEDLLKALKQETKRLNRDIKAEDQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPV9</accession>
    <name>C4YPV9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">beta-glucosidase</fullName>
            <ecNumber evidence="3 6">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_02513</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3 6"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPV9"/>
    <dbReference type="PaxDb" id="5476-C4YPV9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02513"/>
    <dbReference type="HOGENOM" id="CLU_004542_4_0_1"/>
    <dbReference type="OMA" id="GNETGNC"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:004612">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000006">
        <property type="entry name" value="Beta-glucosidase H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF27">
        <property type="entry name" value="BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="7">
        <location>
            <begin position="416"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ44248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="864" mass="97059" checksum="C172BD768C90FE09" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPY0</accession>
    <name>C4YPY0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_02534</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPY0"/>
    <dbReference type="PaxDb" id="5476-C4YPY0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02534"/>
    <dbReference type="HOGENOM" id="CLU_036005_0_0_1"/>
    <dbReference type="OMA" id="VCGFSTH"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000907">
        <property type="term" value="F:sulfonate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044273">
        <property type="term" value="P:sulfur compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="86"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ44269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="388" mass="43524" checksum="F3568EE3CD973491" modified="2010-10-05" version="1">MPSRYTRPSEALGGGTEYVSDNKGFVQVAPKSAQKINIESSPYLPTWDRNESYKPYEFLEFHDPALRANKDLPNLFPKGGDYTTSNISPKLGTEIKGIQLSQLNDAAKDEVALLAAQRGVLVFRDQDFIDKGPEFVTKYVSHYGPLHIHPTSGAPKDHPDIHVVLSGDTKEYPFEKKTNLVALHSDVSYELNPTALSFLAATNIPQSGGGDTVFVDTVEAYNRLSPLFKEKLEGLKAVHSAVEQANFAIFKKGHVKRHPVENVHPIVRTTPLGQKVLYVNNGFTRRIEGLKEEESSYLLNFLLDHIWKGHDFQIRAHWEPNTVVIFDNRVVGHTAILDFDTTDSRLIIRASARGERPVSDLKDLNKPDENLVYHGAEYLGDRLENLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ09</accession>
    <name>C4YQ09_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ09"/>
    <dbReference type="PaxDb" id="5476-C4YQ09"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02563"/>
    <dbReference type="HOGENOM" id="CLU_037330_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="493"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="537" mass="60814" checksum="60705CA13E08B150" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ31</accession>
    <name>C4YQ31_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_02585</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ31"/>
    <dbReference type="PaxDb" id="5476-C4YQ31"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02585"/>
    <dbReference type="HOGENOM" id="CLU_099502_3_2_1"/>
    <dbReference type="OMA" id="CTTHFWG"/>
    <dbReference type="OrthoDB" id="1697690at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ44320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="117" mass="13381" checksum="9343BA84D0BCA3DC" modified="2010-10-05" version="1">MSSFKKFTDFLFSKQSLRYVCTTHFWGPVSNFGIPIAAILDLKKDPDLISGPMTGSLILYSLVFMRYSMAVTPQNYLLFGCHFVNELAQLSQGFRWVKHHYDTSSNDGEDTKKITQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQE0</accession>
    <name>C4YQE0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peptide transporter PTR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_02697</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQE0"/>
    <dbReference type="PaxDb" id="5476-C4YQE0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02697"/>
    <dbReference type="HOGENOM" id="CLU_004790_4_2_1"/>
    <dbReference type="OMA" id="QMMGVWF"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ44429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="576" mass="64455" checksum="2E7407E48BA80424" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQE1</accession>
    <name>C4YQE1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein kinase RAD53</fullName>
            <ecNumber evidence="7">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_02698</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="7"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQE1"/>
    <dbReference type="PaxDb" id="5476-C4YQE1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02698"/>
    <dbReference type="HOGENOM" id="CLU_379543_0_0_1"/>
    <dbReference type="OMA" id="HEGPLKD"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009202">
        <property type="term" value="P:deoxyribonucleoside triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000651">
        <property type="entry name" value="Serine/threonine-protein kinase RAD53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016256">
        <property type="entry name" value="Ser/Thr_kinase_Rad53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000661">
        <property type="entry name" value="Ser/Thr_PK_RAD53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="FHA" evidence="10">
        <location>
            <begin position="62"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="170"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="10">
        <location>
            <begin position="583"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="487"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="487"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ44430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="699" mass="78355" checksum="FE972D3E4B16E63A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQM2</accession>
    <name>C4YQM2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_02781</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQM2"/>
    <dbReference type="PaxDb" id="5476-C4YQM2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02781"/>
    <dbReference type="HOGENOM" id="CLU_114656_0_1_1"/>
    <dbReference type="OMA" id="DIMAQGI"/>
    <dbReference type="OrthoDB" id="1227494at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001859">
        <property type="entry name" value="Ribosomal_P1/P2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00456">
        <property type="entry name" value="RIBOSOMALP2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ44511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="110" mass="11048" checksum="E9FF58C045525B5A" modified="2009-07-28" version="1">MKYLAAYLLLVQGGNTSPSASDITALLESVGVEAEESRLQALLKDLEGKDLQELIAEGNTKLASVPSGGAAAGGASASAGAAAGGAAEAEEEKEEAKEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQP3</accession>
    <name>C4YQP3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleolar complex protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_02802</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQP3"/>
    <dbReference type="PaxDb" id="5476-C4YQP3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02802"/>
    <dbReference type="HOGENOM" id="CLU_008874_0_0_1"/>
    <dbReference type="OMA" id="KSCWPSL"/>
    <dbReference type="OrthoDB" id="441771at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007276">
        <property type="entry name" value="Nop14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183">
        <property type="entry name" value="NOP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04147">
        <property type="entry name" value="Nop14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="144"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="302"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="816"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="759"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="302"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="338"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="822"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ44532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="838" mass="97003" checksum="B9F7221A3F339D7A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQU3</accession>
    <name>C4YQU3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Iron transport multicopper oxidase FET3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CAWG_04440</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQU3"/>
    <dbReference type="PaxDb" id="5476-C4YQU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04440"/>
    <dbReference type="HOGENOM" id="CLU_006504_7_3_1"/>
    <dbReference type="OMA" id="GHNFQIV"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13851">
        <property type="entry name" value="CuRO_1_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13899">
        <property type="entry name" value="CuRO_3_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000022">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000024">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000025">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0186">Copper</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 19" id="KW-0732">Signal</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944402" evidence="19">
        <location>
            <begin position="19"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="22">
        <location>
            <begin position="29"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="20">
        <location>
            <begin position="160"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="21">
        <location>
            <begin position="375"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EEQ46096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="620" mass="70883" checksum="A907CD1790F9F612" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR52</accession>
    <name>C4YR52_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_04551</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YR52"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04551"/>
    <dbReference type="HOGENOM" id="CLU_000192_5_3_1"/>
    <dbReference type="OMA" id="DVRFLHK"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01377">
        <property type="entry name" value="MYSc_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000001">
        <property type="entry name" value="Myosin heavy chain, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.270.10">
        <property type="entry name" value="Myosin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="11">
        <location>
            <begin position="77"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="8">
        <location>
            <begin position="669"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1381"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="861"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1306"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1456"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1573"/>
            <end position="1785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="194"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ46205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1816" mass="210777" checksum="DB6A2FFAD4AB940E" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRN3</accession>
    <name>C4YRN3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Geranylgeranyl pyrophosphate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_04735</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRN3"/>
    <dbReference type="SMR" id="C4YRN3"/>
    <dbReference type="PaxDb" id="5476-C4YRN3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04735"/>
    <dbReference type="HOGENOM" id="CLU_014015_6_0_1"/>
    <dbReference type="OMA" id="CAFLEML"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000057">
        <property type="entry name" value="Geranylgeranyl pyrophosphate synthetase, putative [includes: dimethylallyltranstransferase (Ec 2.5.1.1) geranyltranstransferase (Ec 2.5.1.10) farnesyltranstransferas (Ec 2.5.1.29)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ46386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="38083" checksum="8E1E9ED5231D4DF6" modified="2010-10-05" version="1">MQLDINKLIQPTEAYVPESSDPIVQPYTYISETPSNNQNVRTRFLHAFNDLFYKISDESLLARISEIISVFHNSSLLIDDIEDDSKYRRGVPVAHVKYGIPTTINCGNLMYFVALQQAQQLSGPHGSMEVKFKSSQILIDELLNLHRGQGLDIYWRDYLKKLEKLPDVEEYLEMIKDKTGGLFRLAIKLLSLYSDVKENDQLISLANLMGILYQVRDDYLNLVDAKYSAMKGTTCEDLIEGKLSLPILHCLRTTKDSPVHKILYDYDSSSDRVSQNSLIDLSLSFMKNESKSLEYTLNLIKVLEKKLRQLILKYPESENSALLKIVERLCDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS44</accession>
    <name>C4YS44_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycoside hydrolase family 5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_04902</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS44"/>
    <dbReference type="PaxDb" id="5476-C4YS44"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04902"/>
    <dbReference type="HOGENOM" id="CLU_009024_0_1_1"/>
    <dbReference type="OMA" id="AACRYFA"/>
    <dbReference type="OrthoDB" id="9971853at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000174">
        <property type="entry name" value="YIR007W-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF5">
        <property type="entry name" value="ERGOSTERYL-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="5">
        <location>
            <begin position="768"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="699"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="701"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ46547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="897" mass="102660" checksum="985E6000328078DB" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS75</accession>
    <name>C4YS75_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_04934</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS75"/>
    <dbReference type="PaxDb" id="5476-C4YS75"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04934"/>
    <dbReference type="HOGENOM" id="CLU_010475_1_0_1"/>
    <dbReference type="OMA" id="LEGWMRF"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000626">
        <property type="entry name" value="Transmembrane ubiquitin ligase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021319">
        <property type="entry name" value="DUF2921"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF162">
        <property type="entry name" value="TRANSMEMBRANE E3 UBIQUITIN-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11145">
        <property type="entry name" value="DUF2921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946864" description="RING-type E3 ubiquitin transferase" evidence="16">
        <location>
            <begin position="26"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="569"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="599"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="630"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="712"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ46578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="776" mass="88960" checksum="D74AF55813AEF82F" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS83</accession>
    <name>C4YS83_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_04942</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS83"/>
    <dbReference type="PaxDb" id="5476-C4YS83"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04942"/>
    <dbReference type="HOGENOM" id="CLU_003181_2_2_1"/>
    <dbReference type="OMA" id="SCCILNI"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000024">
        <property type="entry name" value="Voltage-gated chloride channel, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0868">Chloride</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ46586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="878" mass="99066" checksum="A2C8021D5CE3F7F4" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS87</accession>
    <name>C4YS87_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_04946</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YS87"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04946"/>
    <dbReference type="HOGENOM" id="CLU_020873_0_0_1"/>
    <dbReference type="OMA" id="TKLWGYE"/>
    <dbReference type="OrthoDB" id="21643at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="15"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="335"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="362"/>
            <end position="400"/>
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        <location>
            <begin position="477"/>
            <end position="597"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="622"/>
            <end position="656"/>
        </location>
    </feature>
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        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="516"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="583"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="639"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ46590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="691" mass="79742" checksum="7E22630203774B60" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSA4</accession>
    <name>C4YSA4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Agglutinin-like protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_04966</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
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            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ALS family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSA4"/>
    <dbReference type="PaxDb" id="5476-C4YSA4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04966"/>
    <dbReference type="HOGENOM" id="CLU_011374_0_0_1"/>
    <dbReference type="OMA" id="VVEPHNP"/>
    <dbReference type="OrthoDB" id="4023732at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030446">
        <property type="term" value="C:hyphal cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030445">
        <property type="term" value="C:yeast-form cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043710">
        <property type="term" value="P:cell adhesion involved in multi-species biofilm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043709">
        <property type="term" value="P:cell adhesion involved in single-species biofilm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1280:FF:000001">
        <property type="entry name" value="Agglutinin-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2430">
        <property type="entry name" value="Agglutinin-like protein, N-terminal domain, N2 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008440">
        <property type="entry name" value="Agglutinin-like_ALS_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024672">
        <property type="entry name" value="Agglutinin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043063">
        <property type="entry name" value="Agglutinin-like_N_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033504">
        <property type="entry name" value="ALS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011252">
        <property type="entry name" value="Fibrogen-bd_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793:SF2">
        <property type="entry name" value="AGGLUTININ-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793">
        <property type="entry name" value="ALPHA-AGGLUTININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05792">
        <property type="entry name" value="Candida_ALS"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11766">
        <property type="entry name" value="Candida_ALS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01056">
        <property type="entry name" value="Candida_ALS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="Bacterial adhesins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944442" description="Agglutinin-like protein N-terminal domain-containing protein" evidence="16">
        <location>
            <begin position="18"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="Agglutinin-like protein N-terminal" evidence="17">
        <location>
            <begin position="53"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ46607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="751" mass="79432" checksum="2F68BB79B118BAEF" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSS7</accession>
    <name>C4YSS7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_05146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YSS7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05146"/>
    <dbReference type="HOGENOM" id="CLU_2049374_0_0_1"/>
    <dbReference type="OMA" id="FTHCHKY"/>
    <dbReference type="OrthoDB" id="10619742at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="120" mass="13807" checksum="B447B5E15356E28D" modified="2010-10-05" version="1">MRLQSYIQLSLVPYHLYPMILEPYLQGIYIGYMEDAKKSPANGREYSYVDVLIAFVKGSQLEVANANAQVELFNILPVPGQTVGDFIDAIQGKYRQLKQYNNVFVSVRAHVFTHCHKYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSV6</accession>
    <name>C4YSV6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase</fullName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate kinase cytosolic and mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ADK1</name>
        <name evidence="10" type="ORF">CAWG_05175</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <text evidence="6">Predominantly mitochondrial.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate kinase family. AK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSV6"/>
    <dbReference type="SMR" id="C4YSV6"/>
    <dbReference type="PaxDb" id="5476-C4YSV6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05175"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05176"/>
    <dbReference type="HOGENOM" id="CLU_032354_1_0_1"/>
    <dbReference type="OMA" id="VYHEQTA"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03168">
        <property type="entry name" value="Adenylate_kinase_AK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028587">
        <property type="entry name" value="AK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001380">
        <property type="entry name" value="PRK00279.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011100">
        <property type="entry name" value="PRK14527.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="9">
        <location>
            <begin position="161"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="6">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="160"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="90"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="119"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="170"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ46809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="249" mass="27580" checksum="772AB37710929CFE" modified="2009-07-28" version="1">MSIEDLKNTVTKLQERIQELEKKAGIIPDVPKSVRMVLIGPPGAGKGTQAPNLKEKFCACHLATGDMLRAQVAAKTALGVEAKKIMDQGGLVSDEIMVNMIKSELENNQECSKGFILDGFPRTIPQAEKLDSMLESRKTPLEKAVELKIDDELLVARITGRLVHPASGRSYHKLFNPPKKDMTDDVTGEPLVQRSDDNEDALKKRLVTYHKQTEPIVAYYQKTGIWSGVDASQKPTKVWSDILKCLGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT55</accession>
    <name>C4YT55_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_05754</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT55"/>
    <dbReference type="SMR" id="C4YT55"/>
    <dbReference type="PaxDb" id="5476-C4YT55"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05754"/>
    <dbReference type="HOGENOM" id="CLU_008455_11_4_1"/>
    <dbReference type="OMA" id="AYIPSFM"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF31">
        <property type="entry name" value="POLYAMINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="118"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ47191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="563" mass="61745" checksum="3F76B8BFB56B49CF" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTJ0</accession>
    <name>C4YTJ0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ethanolamine kinase</fullName>
            <ecNumber evidence="3">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_05483</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="3"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTJ0"/>
    <dbReference type="PaxDb" id="5476-C4YTJ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05483"/>
    <dbReference type="HOGENOM" id="CLU_012712_1_2_1"/>
    <dbReference type="OMA" id="FALIPKY"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="109"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="109"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ46931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="598" mass="67378" checksum="48AA90520972E078" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTJ1</accession>
    <name>C4YTJ1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_05484</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YTJ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05484"/>
    <dbReference type="HOGENOM" id="CLU_001222_2_0_1"/>
    <dbReference type="OMA" id="FEDIAWD"/>
    <dbReference type="OrthoDB" id="341578at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14046">
        <property type="entry name" value="STKc_EIF2AK4_GCN2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000050">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000231">
        <property type="entry name" value="Serine/threonine-protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016255">
        <property type="entry name" value="Gcn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024435">
        <property type="entry name" value="HisRS-related_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF160">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12745">
        <property type="entry name" value="HGTP_anticodon2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000660">
        <property type="entry name" value="Ser/Thr_PK_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RWD" evidence="17">
        <location>
            <begin position="16"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="240"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="656"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="729"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="798"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1540"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1600"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="80"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="739"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="762"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="798"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="816"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="827"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1615"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="909"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="662"/>
            <end position="670"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="685"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="686"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000660-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000660-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ46932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1763" mass="200954" checksum="05E986A57E27D133" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTU5</accession>
    <name>C4YTU5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GPN-loop GTPase</fullName>
            <ecNumber evidence="7">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_05590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="7"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTU5"/>
    <dbReference type="PaxDb" id="5476-C4YTU5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05590"/>
    <dbReference type="HOGENOM" id="CLU_037460_1_3_1"/>
    <dbReference type="OMA" id="MIIVFNK"/>
    <dbReference type="OrthoDB" id="243313at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000579">
        <property type="entry name" value="GPN-loop GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="274"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="359"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ47036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="388" mass="44277" checksum="8377DFF5F58B340C" modified="2009-07-28" version="1">MPTPPPTIICIGMAGSGKTTFVQRLNSHLHSKKTPPYLINLDPAVLKIPFGANIDIRDSVKYKKVMEEYNLGPNGAIVTSLNLFSTKIDQVIKLIDKKQDKINNVVIDTPGQIECFIWSASGSIITESFASEFPTVIAYIVDTPRNTSPTTFMSNMLYACSILYKTKLPMIVVFNKTDVTKDDFAKEWMTDFESFQMAIQKDKDLNNEQGSGYMSSLINSMSLMLEEFYSNLDVVGVSSYTGQGFDKFMEAVDNKVDEYNEFYKAERERILKQKEEDEKKRQTKSLNKLMKDMKMKDTKGDHTKKDSEVLSDYEEDDNEIDDEIQGEVLRDEDEPEREYTFPEDRQSEVNSRTDADLQSRYQQAFESTAKPASSKTAENIANYINRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTX2</accession>
    <name>C4YTX2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_05618</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTX2"/>
    <dbReference type="PaxDb" id="5476-C4YTX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05618"/>
    <dbReference type="HOGENOM" id="CLU_897131_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF-2 N-terminal" evidence="8">
        <location>
            <begin position="161"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="239"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ47063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="34569" checksum="EE73071AD6FA0060" modified="2009-07-28" version="1">MLSKTVSKVACARPIWRRLYANSSNKVGSPESTTESKPKVNRFAKQYADQDQNRNRLQSGSNRTIPRDPNPSNEGPGKNSSNTNRQTSAKQNLEKLKQNRSQQIRSGQEKITRSGSANSGSSANSSSQPRAPLSQSAPRKRIQPKKIKKTVKKLVKIQLPPFITASNLATIMHVPLNDVFKKLEGLGFEDIRHNYILDRENAAMVADEYGIEVEVVEESGDDLFPAPIKPDLLVERPPVVTIMGHVDHGKTTILDYLRKSSIVSQEFGGITQHIGAFSVTTPKSKKRITFLDTPGHAAFLKMRERRCHNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTX7</accession>
    <name>C4YTX7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lipase</fullName>
            <ecNumber evidence="5">3.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_05624</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:12045"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="5"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTX7"/>
    <dbReference type="SMR" id="C4YTX7"/>
    <dbReference type="ESTHER" id="canal-LIP9">
        <property type="family name" value="Fungal-Bact_LIP"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YTX7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05624"/>
    <dbReference type="HOGENOM" id="CLU_029538_5_0_1"/>
    <dbReference type="OMA" id="AREYPEM"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR029171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ47068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="453" mass="49232" checksum="6F96E2D0323F7FEE" modified="2009-07-28" version="1">MLYLILFLIAPIYAGVLLPTKPSIDPFYNAPEGFKNATVGDILQFRKTPKSITGGFVPLNVQNSWQFLVRSEDSFGNPNVIVTTVIEPVNADPSKIASYQVSENAARADCAPSYALQFGSDVSTLATQAETYLLAPLLDKGYYVVSPDYEGPKSTFTVGKQSGQAVLNSIRASLKSGKITNIAEDAKVLMWGYSGGSLASGWAAALQPDYAPELSRNLLGVALGGFITNVTATVEATDDTIFAGIAANVLGGIANEYPEFKSILQNDTNKSSIFNKINNHCLTDSFIKYVGARFLTGDNKVFKSGWNIFKNLVVSKIVKDNGLVYQKQLIPTIPVFIYHGSMDQISPILNPKKTYQNWCDAGISSIEFAEDLTNGHFTESIVGAPAALTWIIDRFSNKPPVDGCQHVVRTTNYEYPNVSSSILDYFKAAMDVVAQQGLGPNIQKDQLEIKSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTY3</accession>
    <name>C4YTY3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_05631</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29535"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19518"/>
            <dbReference type="Rhea" id="RHEA-COMP:19519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132517"/>
            <dbReference type="ChEBI" id="CHEBI:132519"/>
            <dbReference type="EC" id="2.4.1.260"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29536"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTY3"/>
    <dbReference type="PaxDb" id="5476-C4YTY3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05631"/>
    <dbReference type="HOGENOM" id="CLU_008917_4_0_1"/>
    <dbReference type="OMA" id="WWVEVRM"/>
    <dbReference type="OrthoDB" id="19039at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052917">
        <property type="term" value="F:dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF1">
        <property type="entry name" value="DOL-P-MAN:MAN(7)GLCNAC(2)-PP-DOL ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ47074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="584" mass="66104" checksum="3B187BCFB762A3F6" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTY6</accession>
    <name>C4YTY6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein bL21m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTY6"/>
    <dbReference type="PaxDb" id="5476-C4YTY6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05634"/>
    <dbReference type="HOGENOM" id="CLU_061463_2_1_1"/>
    <dbReference type="OMA" id="ITKEPRY"/>
    <dbReference type="OrthoDB" id="5994at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="bL21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="bL21-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="L21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ47077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="160" mass="17979" checksum="D8F65A514DC2DEFA" modified="2009-07-28" version="1">MFRSVSKTIRPISWVNATRLYSAANASTTTTITTTSSSPLSTLKLSSNGSRDLYAIFRLHNLPYLVTKGDKVYLPYKLKNASVGDVLNLNDVVTLGSPQYTLNMKEGISPELFDLKASVVEITKEPRYQVTRKKQRCRTTKTTQVDPFQTVLMINELKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTZ4</accession>
    <name>C4YTZ4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_05642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTZ4"/>
    <dbReference type="PaxDb" id="5476-C4YTZ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05642"/>
    <dbReference type="HOGENOM" id="CLU_480671_0_0_1"/>
    <dbReference type="OMA" id="FHEELMM"/>
    <dbReference type="OrthoDB" id="28413at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ47085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="59836" checksum="7F45450707D6C388" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCY9</accession>
    <name>C4YCY9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_00376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCY9"/>
    <dbReference type="PaxDb" id="5476-C4YCY9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00376"/>
    <dbReference type="HOGENOM" id="CLU_016174_1_1_1"/>
    <dbReference type="OMA" id="ANKYHIA"/>
    <dbReference type="OrthoDB" id="4019115at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ42175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="602" mass="69155" checksum="424D1B1AE8C60307" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD49</accession>
    <name>C4YD49_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_00439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD49"/>
    <dbReference type="PaxDb" id="5476-C4YD49"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00439"/>
    <dbReference type="HOGENOM" id="CLU_1038270_0_0_1"/>
    <dbReference type="OMA" id="SLHKGYH"/>
    <dbReference type="OrthoDB" id="4018979at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ42235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="270" mass="31023" checksum="CCAE4D40DB608E79" modified="2010-10-05" version="1">MNANQLRIPKTLHFADEISHLNSNFISVNSYNQNPTSTSTSTSTLANPRSINKFINSTPKLPLAVNQNSNSLIYDIIDLYLLPDTAPEELDSKTLSANDKHNVQPALFASLHKGYHYFFGNDYLPSTCNSVNDENTRVVLDMNMNMNDANTAIYHDENIETQSINMWFKNKSAGVFHKLKSFGHRSSSTTTNRTNFKAGETVDEKLKSLFSETTIEENNLKEIVEQRPKRRVTIQEKEDIIFPNYYERKSPTRFRRNITRKLSSFRRSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDB0</accession>
    <name>C4YDB0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Protein ARG5,6, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CAWG_00500</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">WO-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 18">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">In the C-terminal section; belongs to the NAGSA dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">In the N-terminal section; belongs to the acetylglutamate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDB0"/>
    <dbReference type="PaxDb" id="5476-C4YDB0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00500"/>
    <dbReference type="HOGENOM" id="CLU_006384_4_0_1"/>
    <dbReference type="OMA" id="IAFIPHV"/>
    <dbReference type="OrthoDB" id="438291at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04252">
        <property type="entry name" value="AAK_NAGK-fArgBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23936">
        <property type="entry name" value="AGPR_C_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24149">
        <property type="entry name" value="AGPR_N_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04263">
        <property type="entry name" value="DUF619-NAGK-FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000019">
        <property type="entry name" value="Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000029">
        <property type="entry name" value="Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000011">
        <property type="entry name" value="N-acetyl-gamma-glutamyl-phosphate reductase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058924">
        <property type="entry name" value="AGPR_dimerisation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041734">
        <property type="entry name" value="NAGK-fArgBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011241">
        <property type="entry name" value="NAGK/NAGSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF0">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22698">
        <property type="entry name" value="Semialdhyde_dhC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036440">
        <property type="entry name" value="ARG5-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 18" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="11 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="15 18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16 18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12 18" id="KW-0521">NADP</keyword>
    <keyword evidence="9 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="21">
        <location>
            <begin position="341"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="509"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="active site" evidence="19">
        <location>
            <position position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00072977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR036440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EEQ42296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="857" mass="95110" checksum="DB60C27F095216D4" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDP9</accession>
    <name>C4YDP9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="8">ATase</shortName>
            <ecNumber evidence="3 8">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_00646</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="3 8"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDP9"/>
    <dbReference type="MEROPS" id="C44.001"/>
    <dbReference type="PaxDb" id="5476-C4YDP9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00646"/>
    <dbReference type="HOGENOM" id="CLU_022389_2_1_1"/>
    <dbReference type="OMA" id="IRHFGVK"/>
    <dbReference type="OrthoDB" id="191723at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11907">
        <property type="entry name" value="AMIDOPHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 8 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="2"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ42435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="537" mass="59573" checksum="1DA3DB22750D5A8B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDQ5</accession>
    <name>C4YDQ5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">URB1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDQ5"/>
    <dbReference type="PaxDb" id="5476-C4YDQ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00652"/>
    <dbReference type="HOGENOM" id="CLU_451256_0_0_1"/>
    <dbReference type="OrthoDB" id="72892at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039844">
        <property type="entry name" value="URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021714">
        <property type="entry name" value="URB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500:SF0">
        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500">
        <property type="entry name" value="NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11707">
        <property type="entry name" value="Npa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="URB1 N-terminal" evidence="1">
        <location>
            <begin position="60"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="605" mass="69893" checksum="225D8EEB18E11DF3" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDS9</accession>
    <name>C4YDS9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_00677</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxin-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDS9"/>
    <dbReference type="PaxDb" id="5476-C4YDS9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00677"/>
    <dbReference type="HOGENOM" id="CLU_017002_0_0_1"/>
    <dbReference type="OMA" id="WLYKQQL"/>
    <dbReference type="OrthoDB" id="45930at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006966">
        <property type="entry name" value="Peroxin-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080:SF1">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04882">
        <property type="entry name" value="Peroxin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ42465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="463" mass="52417" checksum="0B82B06587117228" modified="2009-07-28" version="1">MAIFSSLAGFFNRNKRKIFITSAVTVSIYLLINEFVIKKFRNYQNALRQELLFKQQIKQRFIQTQQDCYYTILALLPVLAAPIIDSLPVELITQALRLKKNNSSQQATSGSNSELTADNLNLLDNNNNPESKLSIYMSKSKTELWNLLKIKTITRTLTLLYTVSGLFLITRLQLNILARRSYLESAIQMAGVKSTNNDIDPHENYIIEQSYLSLSWWLLNKGWSNLSSIIEALVVKKFEKITPKTELSINEFEFDLIEIINEINSNNKEYILANLFPINYSDLLETILNTNSDLIHHLDSPESNLIKLINETNAIMLDNNLYFFDLLNALIMNTVSTLTANLSFSLGANNSLNNSLLMASSGNLAAHGENPKVVDITHNDQSFKLASFLAQLSVQNNIMIDNDNLKTEDISPKHESDLEEILNSLNGGTNELPTESYGNVYINNLNQLEELDDFSAGIYSNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDW4</accession>
    <name>C4YDW4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_00712</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDW4"/>
    <dbReference type="PaxDb" id="5476-C4YDW4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00712"/>
    <dbReference type="HOGENOM" id="CLU_035730_3_1_1"/>
    <dbReference type="OMA" id="RNGHGEN"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05384">
        <property type="entry name" value="CAP_PRY1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944647" description="SCP domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="181"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ42500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="317" mass="34058" checksum="BC91CE1C5E770B84" modified="2009-07-28" version="1">MKFLQSFPVILAVFSFAANLVSSKLVYEYETKYVTVEIVTIVSGETTYTTERLKTNGPTSTTTTIVIPSSKPSSPESKPKSDSQPTFQSPSPVQITPSTTSINNAPSPTKPETTVTASPAVIVHTSVFVVTPNSAPTTSSSPPNIVQQVKAAITPSAPKPQPQPQPQENNSGTNDDSQLSSFSRQILEAHNIKRASHGVNPLTWSNELYNYANKVASSYDCSGNLRHTSGPYGENLALGYSSGANAVSAWYSEGFNFGGAGKLNHFTQVVWKSTTQLGCAYKDCRAKGWGLYVICNYQKPGNIIGQELANILPLIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDY8</accession>
    <name>C4YDY8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Pre-rRNA-processing protein IPI3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_00737</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the WD repeat IPI3/WDR18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDY8"/>
    <dbReference type="PaxDb" id="5476-C4YDY8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00737"/>
    <dbReference type="HOGENOM" id="CLU_029749_4_0_1"/>
    <dbReference type="OMA" id="WEAHYNK"/>
    <dbReference type="OrthoDB" id="756370at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 7 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="146"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="462"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ42524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="505" mass="55892" checksum="9B6D2412A4B1DFD4" modified="2009-07-28" version="1">MDEVVFYIAQGDPADKHSQESYGYVTSIHSSKQYASYRQADSHINGTAITGIGPGERIFTAVPNKALINVYSWGKESVDQRIPIPEALTCITLINHPNGSNNNSDNDDNQLYKLPNYRVPWLLAGGSKSGKLYIWELSSGNLLCVRDAHYQGIITIKGSSCGTFLITGGEDARCLVWNLAELISIYDKSDHQVKPYWQITDNTLPLTDLCLNDTHNINDLKLYTTSKDSTARIYDIVTKSLLTTFILPSSAECITKDPANRALYVGLNNGLVRAIPLYSINSHTSVLESIGGMNKIITVDADPNLKETFVAHQQKTKTGDDKPVVVTKLTISFDGTSIISGDSEGRVFVSDIVTKQVVKSFTPCNSPIAYIAVETVPDDFVNNLATSTTTNKADKKHRMIPQFKRVLASTNSEEHQIFLDIPGKTTATTNAIGNIDFATWLQSKQSEELQFKNLSGINSIVKKVGNENVSDLEEKLQRVSQAYTELRNKHEELIKEHAKLLDKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YE99</accession>
    <name>C4YE99_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YE99"/>
    <dbReference type="PaxDb" id="5476-C4YE99"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00853"/>
    <dbReference type="HOGENOM" id="CLU_050549_0_0_1"/>
    <dbReference type="OMA" id="PECKKMS"/>
    <dbReference type="OrthoDB" id="4095156at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="373" mass="42120" checksum="4F65B7DCAEB2F565" modified="2009-07-28" version="1">MPANGSFEKMSRPATAFQKVLDKVGSVFSSTETSRSQHDSQLDDKATNIFSVSSQKLYSKLSKMLKIETRSKNLKMELCNDFGVWGQSIPNLESSAFVKEFSALLNTQINNQTILQEKMERLKLSLSFVNEREKKQKGLITAKLKLEKQLKEAKAKFGPNASNTILLNEKAEEVDCNLQVVEQQYIRSITNDLKDALIDYAYSMSAAARKAEDSSSSFIQYMTAVENDMVAGSIENDFVRFSPNKYSKLSKRKESKYQSPNLLDGGIVGSGVQQLKVKNYNLPTPQSPCPECKKMSPCIHTDGAKVIQPSQRDNNHQQQHQQVHQQTQLRTFSQPNRNFTVNLQHPSDDSLGNEVPLYTTNRENSMPFSDHWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YED6</accession>
    <name>C4YED6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HRDC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_00893</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the exosome component 10/RRP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YED6"/>
    <dbReference type="PaxDb" id="5476-C4YED6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00893"/>
    <dbReference type="HOGENOM" id="CLU_010129_3_2_1"/>
    <dbReference type="OMA" id="TMDIIWL"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06147">
        <property type="entry name" value="Rrp6p_like_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000059">
        <property type="entry name" value="Exosome complex exonuclease Rrp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012588">
        <property type="entry name" value="Exosome-assoc_fac_Rrp6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049559">
        <property type="entry name" value="Rrp6p-like_exo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124:SF47">
        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08066">
        <property type="entry name" value="PMC2NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="HRDC" evidence="10">
        <location>
            <begin position="459"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="653"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="653"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="719"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="740"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="750"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="777"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ42672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="786" mass="90531" checksum="BF5C6A7B1B242072" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEQ4</accession>
    <name>C4YEQ4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FK506-binding protein</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_01012</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEQ4"/>
    <dbReference type="PaxDb" id="5476-C4YEQ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01012"/>
    <dbReference type="HOGENOM" id="CLU_022297_3_1_1"/>
    <dbReference type="OMA" id="CPPHMAY"/>
    <dbReference type="OrthoDB" id="77911at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023566">
        <property type="entry name" value="PPIase_Fpr3/Fpr4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001473">
        <property type="entry name" value="FK506-bp_FPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="342"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="37"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="170"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="181"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="226"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ42790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="428" mass="47958" checksum="F8CABE6609BB4EB9" modified="2009-07-28" version="1">MSNLTPIATYNLALQPFQPVPAIEDDFPISIRITLASLDPEAADDKAEPSSLRILKKSNSLLSDDYFEDDDDDEEDDEEDELDDEEEEEAKEEKFSKKSNGKKSSKKDEDEEDDDEEEDDEDDDEDEDDVSEYIVCTLSPKHQYQQTLDLTITPDEEVYFVVTGSYPIHLTGNYIEHPADQDEEDYDDEDEDYDDEYDLSPDEDEIIYGAPLDDEYDDEEESEEEGTPKIEEIVEEKEKEKVKESPKESKKRVAEESTSKKSKKAKKDEKKSVQFSKELEQGPTGSTLVEKDNKKATPTKDKKETPVKDDGDKKKKFPTKTLLGGVITEDRKIGSGATAKSGAKVGIRYIGKLKNGKVFDKNTSGKPFSFKLGKGECIKGFDLGVTGMAVGGERRVIIPPKMGYGSQALPGIPANSELTFDIKLVSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEY5</accession>
    <name>C4YEY5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_01094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEY5"/>
    <dbReference type="PaxDb" id="5476-C4YEY5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01094"/>
    <dbReference type="HOGENOM" id="CLU_367267_0_0_1"/>
    <dbReference type="OMA" id="NKILYQW"/>
    <dbReference type="OrthoDB" id="4822at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045211">
        <property type="entry name" value="TFP11/STIP/Ntr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329:SF1">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="83"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ42871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="725" mass="83767" checksum="F1A56701658980E5" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF37</accession>
    <name>C4YF37_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_01148</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Lipid-anchor</topology>
            <topology evidence="8">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF37"/>
    <dbReference type="PaxDb" id="5476-C4YF37"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01148"/>
    <dbReference type="HOGENOM" id="CLU_021855_2_0_1"/>
    <dbReference type="OMA" id="ICLRDIP"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030446">
        <property type="term" value="C:hyphal cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030445">
        <property type="term" value="C:yeast-form cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF10">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005125133" description="1,3-beta-glucanosyltransferase" evidence="8">
        <location>
            <begin position="24"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="10">
        <location>
            <begin position="429"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="533"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="569"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="596"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ42923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="641" mass="72194" checksum="48C917FD8FEBF064" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF90</accession>
    <name>C4YF90_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_01202</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. CAR1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EEQ42976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF90"/>
    <dbReference type="PaxDb" id="5476-C4YF90"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01202"/>
    <dbReference type="HOGENOM" id="CLU_008455_13_0_1"/>
    <dbReference type="OMA" id="MWTVRKR"/>
    <dbReference type="OrthoDB" id="4500315at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:001026">
        <property type="entry name" value="AGL069Cp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="521"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="550"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="74"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="309"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ42976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="624" mass="69644" checksum="6AA62C70A8F01CAB" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF92</accession>
    <name>C4YF92_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_01205</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_001265_54_5_1"/>
    <dbReference type="OMA" id="AWWACGI"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
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    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
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    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="249"/>
        </location>
    </feature>
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            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="517"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="281"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="333"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ42978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="71429" checksum="1232F66C07D4294A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFB3</accession>
    <name>C4YFB3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFB3"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01228"/>
    <dbReference type="HOGENOM" id="CLU_158761_0_0_1"/>
    <dbReference type="OMA" id="CITQICI"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="120" mass="13874" checksum="6F8113123EF8005C" modified="2009-07-28" version="1">MIRGFNSGQSNWCLSDNRDNNMSTRTLLTATNLALIFCITQICILIKWLAAIVLNNYCSCLHVIDSIKSKIKMNSYRQTHRIILVCSFLGLLVLWRQWVTAKLIKEMSKLCFCPTNQWLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFB7</accession>
    <name>C4YFB7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein ABC1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_01233</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFB7"/>
    <dbReference type="PaxDb" id="5476-C4YFB7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01233"/>
    <dbReference type="HOGENOM" id="CLU_006533_9_2_1"/>
    <dbReference type="OMA" id="PEYYVPR"/>
    <dbReference type="OrthoDB" id="201153at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="6">
        <location>
            <begin position="220"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ43003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="566" mass="64036" checksum="EFBF3E9D391719DE" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG46</accession>
    <name>C4YG46_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Ribokinase</fullName>
            <shortName evidence="12">RK</shortName>
            <ecNumber evidence="2 12">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RBK1</name>
        <name evidence="15" type="ORF">CAWG_00164</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="2 12"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YG46"/>
    <dbReference type="PaxDb" id="5476-C4YG46"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00164"/>
    <dbReference type="HOGENOM" id="CLU_027634_2_0_1"/>
    <dbReference type="OMA" id="DIVLIQQ"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000144">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="14">
        <location>
            <begin position="7"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="14">
        <location>
            <begin position="283"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="15"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="43"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="298"/>
            <end position="303"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="342"/>
            <end position="343"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ41970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="393" mass="42133" checksum="EEB1DDDC5B9653FC" modified="2009-07-28" version="1">MPSSNPSITIIGSLNYDLVTYTNKVPQGGETYQANSFETHVGGKGLNESIAVAKLTPKNSVLLSSTTTTTTSGDGDGAIRMVGKIGDDSFGQQLKQFLIDNKVNVDHVHTVNNQTSGVAVILVEEETGENRILITSGANGELKLDDKEYESIFPKTTGSITTTTTTTKEGEGGYLSFVILQNEYPDTVKSINWIKSNRPQLNIAYNPSPFKSELITKELLSKIDLLIVNEGEALDVANHLLKNSHQQDLIDKINQINKSNVTNSTGNNHTLLVEVFSKLAIELQKLINPDNIQIIVITMGSKGSIYIAKNSGGGGGSGGSQTTPQFIKSRKVEKVIDTTGAGDTFFGAIVSNLALGKSIDYAIKFATTASSLTIQKKGAAEGIPSYEEVMEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGE2</accession>
    <name>C4YGE2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_03118</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YGE2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03118"/>
    <dbReference type="HOGENOM" id="CLU_000335_1_0_1"/>
    <dbReference type="OMA" id="MNPKEFN"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004219">
        <property type="entry name" value="ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004220">
        <property type="entry name" value="ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000133">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000013">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048863">
        <property type="entry name" value="BRR2_plug"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21188">
        <property type="entry name" value="BRR2_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="383"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="574"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1216"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ44824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1987" mass="227102" checksum="34C5D2201E896508" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGE9</accession>
    <name>C4YGE9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoadenylyl-sulfate reductase (thioredoxin)</fullName>
            <ecNumber evidence="3">1.8.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">3'-phosphoadenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">PAPS reductase, thioredoxin dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">PAdoPS reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_03125</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[thioredoxin]-disulfide + sulfite + adenosine 3',5'-bisphosphate + 2 H(+) = [thioredoxin]-dithiol + 3'-phosphoadenylyl sulfate</text>
            <dbReference type="Rhea" id="RHEA:11724"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="EC" id="1.8.4.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.8" evidence="3"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGE9"/>
    <dbReference type="SMR" id="C4YGE9"/>
    <dbReference type="PaxDb" id="5476-C4YGE9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03125"/>
    <dbReference type="HOGENOM" id="CLU_044089_0_1_1"/>
    <dbReference type="OMA" id="PIARWTQ"/>
    <dbReference type="OrthoDB" id="7869097at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23945">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000151">
        <property type="entry name" value="Phosphoadenosine phosphosulfate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011800">
        <property type="entry name" value="PAPS_reductase_CysH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02057">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002537">
        <property type="entry name" value="PRK02090.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509:SF1">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="13">
        <location>
            <begin position="38"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ44831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="252" mass="29169" checksum="F42F4D8803FABD7D" modified="2010-10-05" version="1">MGNIVQLTPEHISFLNEHLKTLSAYNIIKWAYFTFPNLYQTTAFGLTGLVTVDIISKLSQELEKDHLIDLIFLDTLYHFPQTHELVQKVEQKYRPKLHVYKPKDVSTEQEFAAKYGDQLWESNDAYYDFLVKVEPSQRAYKELGVSAVLTGRRKSQGGARSELTVLEYEETSGIIKINPLWNWDFKQVKAYIDDNKVPYNELLDLGYKSIGDWHSTVPVADGEDERSGRWKGKAKTECGIHVTTKYTEYMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGH1</accession>
    <name>C4YGH1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_03148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGH1"/>
    <dbReference type="PaxDb" id="5476-C4YGH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03148"/>
    <dbReference type="HOGENOM" id="CLU_016216_3_1_1"/>
    <dbReference type="OMA" id="VNDLRAW"/>
    <dbReference type="OrthoDB" id="10251230at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="318"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="640" mass="72227" checksum="DB3E4D8A1B231D6F" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGJ2</accession>
    <name>C4YGJ2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_03170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGJ2"/>
    <dbReference type="PaxDb" id="5476-C4YGJ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03170"/>
    <dbReference type="HOGENOM" id="CLU_046871_2_0_1"/>
    <dbReference type="OMA" id="KPPHGSE"/>
    <dbReference type="OrthoDB" id="71302at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="bHLHzip_scCBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="bHLH_dom"/>
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        <property type="entry name" value="bHLHzip_scCBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787:SF1">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HLH"/>
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    </dbReference>
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        <property type="entry name" value="HLH"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
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    <feature type="domain" description="BHLH" evidence="5">
        <location>
            <begin position="124"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
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        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
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        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
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        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ44874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="223" mass="25789" checksum="D40314E9C373D85D" modified="2009-07-28" version="1">MEIDAELLTQQASDSAHTDTATAAVAAVNNEQGKELEQTESSTNQTSALDKDDKETKDNLNPREETQSSHQEIDIPKDQLTNQQNLANQHQQYQYHQQLAQTNFKTEPTNSAKPPHGSEEWHRQRRENHKEVERKRRESINTGIRELARLIPTTDTNKAQILQRAVEYIKRLKENENNNIEKWTLEKLLTEQAVSELSASNEKLKHELESAYREIEQLKRGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGP8</accession>
    <name>C4YGP8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_03229</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OMA" id="KLMAPLS"/>
    <dbReference type="OrthoDB" id="273181at2759"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="project" value="GOC"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
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        <property type="entry name" value="Tyr_Pase_AS"/>
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    </dbReference>
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        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
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        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE PPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47550:SF1">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE PPS1"/>
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    </dbReference>
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        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="893"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
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        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="103"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="112"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ44930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1013" mass="116849" checksum="8A2839061C01E7CA" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGY0</accession>
    <name>C4YGY0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_03320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGY0"/>
    <dbReference type="PaxDb" id="5476-C4YGY0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03320"/>
    <dbReference type="HOGENOM" id="CLU_1749382_0_0_1"/>
    <dbReference type="OMA" id="EWKIATE"/>
    <dbReference type="OrthoDB" id="10390809at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ45012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="148" mass="17487" checksum="365708C01833D8A5" modified="2009-07-28" version="1">MHAMLDVVEKFTSLESLNVNFDKLGLVSFVENLKENTLKEIGVPESLDSFKTIYPALLHHRDSIKVIFENQDYFHSNFVEWKIATEPNFDVDLDLDLNLDEFPKLEYVVRNGNIIFVDRNEPYPEFVSVEYHHPRKGYFESHPGWEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGY5</accession>
    <name>C4YGY5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_03326</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGY5"/>
    <dbReference type="SMR" id="C4YGY5"/>
    <dbReference type="PaxDb" id="5476-C4YGY5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03326"/>
    <dbReference type="HOGENOM" id="CLU_106411_0_0_1"/>
    <dbReference type="OMA" id="PGHGKKM"/>
    <dbReference type="OrthoDB" id="1727108at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL24-related N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="87"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ45017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="155" mass="17383" checksum="4DE8E09C953C5484" modified="2010-10-05" version="1">MKIEVDSFSGSKIYPGRGTLFVRGDSKIFRFQSSKSASLFQQRKNPRRISWTVLYRRHHKKGISEEAAKKRTRKTVKHQRAIVGASLELIKERRSQKPSDRKAARDSKLAKDKEAKKAAKAARKAEKAKAVASGASVVSKQQAKGSFQKVKATSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH39</accession>
    <name>C4YH39_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ureidoglycolate lyase</fullName>
            <ecNumber evidence="3">4.3.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ureidoglycolatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_03380</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as secondary nitrogen source when primary sources are limiting.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(S)-ureidoglycolate = urea + glyoxylate</text>
            <dbReference type="Rhea" id="RHEA:11304"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="4.3.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; (S)-allantoin degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ureidoglycolate lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.3" evidence="3"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YH39"/>
    <dbReference type="PaxDb" id="5476-C4YH39"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03380"/>
    <dbReference type="HOGENOM" id="CLU_070848_0_0_1"/>
    <dbReference type="OMA" id="ECYFEPG"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004848">
        <property type="term" value="F:ureidoglycolate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050385">
        <property type="term" value="F:ureidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20298">
        <property type="entry name" value="cupin_UAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.480:FF:000003">
        <property type="entry name" value="Ureidoglycolate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.480">
        <property type="entry name" value="Ureidoglycolate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047233">
        <property type="entry name" value="UAH_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007247">
        <property type="entry name" value="Ureidogly_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024060">
        <property type="entry name" value="Ureidoglycolate_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21221">
        <property type="entry name" value="UREIDOGLYCOLATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21221:SF1">
        <property type="entry name" value="UREIDOGLYCOLATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04115">
        <property type="entry name" value="Ureidogly_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ45071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="213" mass="23693" checksum="91F5F82E16A653D1" modified="2009-07-28" version="1">MVLKTFKVDGISPIKAETLTPENFSKYGGVISADHQLEKVQSSEANYGTAIKIHKVAPIVNNYPNCPSGKEATANWNIFRCKAPKHLINHGSLNSVYTSKVLERHPFSTQTFLPLGQDLHKVSYLVIVAKTDESTEEKLPDPTSIRAFVCKGNQSVTYGIGTWHAPMVVIDEKVPHIDFAVFIHENGVADEDVQECYFEPGYSIVYNQIEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHB8</accession>
    <name>C4YHB8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_03464</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHB8"/>
    <dbReference type="MEROPS" id="C19.088"/>
    <dbReference type="PaxDb" id="5476-C4YHB8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03464"/>
    <dbReference type="HOGENOM" id="CLU_016013_1_0_1"/>
    <dbReference type="OMA" id="WCTYDDE"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
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    </dbReference>
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        </source>
    </evidence>
    <sequence length="737" mass="84199" checksum="04F7C7E51C9734EB" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHJ4</accession>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
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                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
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    </dbReference>
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        </location>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
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                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
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                <person name="Brunke S."/>
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                <person name="Fitzpatrick D.A."/>
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                <person name="Hube B."/>
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                <person name="Logue M.E."/>
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                <person name="Silverstein K.A."/>
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                <person name="Berriman M."/>
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                <person name="Lorenz M.C."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">WO-1</strain>
        </source>
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    </dbReference>
    <dbReference type="GO" id="GO:0005829">
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    </dbReference>
    <dbReference type="GO" id="GO:0033698">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR013904">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28232:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RXT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08595">
        <property type="entry name" value="RXT2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcriptional regulatory protein RXT2 N-terminal" evidence="2">
        <location>
            <begin position="41"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ45299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="318" mass="37463" checksum="E1AFD365C8D2BA68" modified="2009-07-28" version="1">MLDSFSLEVISRFKEALSAQKLDTDRNSKTLNEENESLPVYNRGLKLSKTIQPSFNTLRSKVTEYGGKKYSVLSNESIEIDNLHNKRKWNEIYGDNKQDQNEDDEDDEEDDELEYDEDKEEHPLKKSRIIELLSPLNHPSEIISHPAISKTYKSQTLSKLASELIDLIEIEQTNLNWLNKLLQVLNGEDWFYLLEENWGLKDYDHGLDEDKKKKIEEKENNNKDNTVVEDEFEDEEENKADPFFALPTALKRYETYQQNLESSDPLKEELINYLQVSIQRQHEYIKNLISLRNGLVRADRLKSDLYKWGKEMYEKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHX5</accession>
    <name>C4YHX5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_03679</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHX5"/>
    <dbReference type="PaxDb" id="5476-C4YHX5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03679"/>
    <dbReference type="HOGENOM" id="CLU_047639_2_1_1"/>
    <dbReference type="OMA" id="SPLCGKQ"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946669" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="4">
        <location>
            <begin position="180"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="109"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ45357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="252" mass="26382" checksum="2526A1EED605D374" modified="2009-07-28" version="1">MKFSSVVLSALLANLVASAPIKTVIVTAFTTVLVDSKGNTKIQTEAATATATLSGNAAAANTDVTQEYNTPSTTFTATSYNNNNNWASAPSSVETSIVEPATSEIIEPSTTNNIQTTLSTQTTSSPSTTSATSPSSSSSSSSAQPTGSEFSGEGTFYSTGLGSCGITSTDSDFIVAISHELYDSKSVGNNPNHNPLCNKKIRAFYEGKSVDVTVVDRCEGCAYNDLDFSPAAFDKLADESLGRIDITWEWLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIE0</accession>
    <name>C4YIE0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA-processing protein EBP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIE0"/>
    <dbReference type="PaxDb" id="5476-C4YIE0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04213"/>
    <dbReference type="HOGENOM" id="CLU_036007_3_1_1"/>
    <dbReference type="OMA" id="DAHKGRD"/>
    <dbReference type="OrthoDB" id="443772at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="343"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ45875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="48721" checksum="627B20C5DFA56BA2" modified="2009-07-28" version="1">MARGILKQQLKSHQLIDAIDKAKSKPTKKTPVTEKTVEEEKEIIEAAPVTTKVKSNKKSKKSNTKKDDDYQSEVLSKKEQRRLKKLQTKQQEEEKEAENNEEEEEEEDDDDEEELDLEKLAASESESDINDEEEEEDDDDDDEEEDDEVENNDEAEDDIPLSDVEVDSDADIVPHTKLTINNMAALRESLARIELPWSKHSFIEHQSITSADKTESEIKDIYDDTERELAFYKQGLDAVKQSRKTLLKLKIPFSRPMDYFAEMVKSDEHMDKLKNKLLTEAANKKASEEAKRQRQLKKFGKQVQHATLQERAKQKKETLEKIKSLKKKRGANEISNDDDFQIALEEATENNQKYGHGGSGSGGDNKRRKPNSKRLAKDAKYGFGSKKRGKRENDSASSADISGFSTRKMKGKSTSRPGKSKRSRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIF8</accession>
    <name>C4YIF8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04231</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIF8"/>
    <dbReference type="PaxDb" id="5476-C4YIF8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04231"/>
    <dbReference type="HOGENOM" id="CLU_044091_0_0_1"/>
    <dbReference type="OMA" id="PLCFLIY"/>
    <dbReference type="OrthoDB" id="2504919at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF86">
        <property type="entry name" value="ADR321CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="472"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ45893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="569" mass="63256" checksum="4D5828DF06794D78" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIG5</accession>
    <name>C4YIG5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA methyltransferase 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_04239</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIG5"/>
    <dbReference type="PaxDb" id="5476-C4YIG5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04239"/>
    <dbReference type="HOGENOM" id="CLU_021322_5_1_1"/>
    <dbReference type="OMA" id="RKYAHVH"/>
    <dbReference type="OrthoDB" id="270651at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18105">
        <property type="entry name" value="SpoU-like_MRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047182">
        <property type="entry name" value="MRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047261">
        <property type="entry name" value="MRM1_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103:SF1">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="RNA 2-O ribose methyltransferase substrate binding" evidence="11">
        <location>
            <begin position="156"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ45900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="470" mass="53222" checksum="3174D36A1917E38A" modified="2009-07-28" version="1">MISQKRSFSILSTLLKSKSTSSNDLKPVFKQPHHSNSTKGQPQPQNFEKNLPQPKIELKPWEKQNISKDSFFKRKYGNISPQDRKALNEKVERQRRFRAMKIAHEKSLQEKAYQERERARELAREAKGNGKNFKSGGSSNYDTGVMVDRNDTIFDYVFGTHPVKAVLMAGKRRILDLYTFNNEDPDIVKLAMEKYGIVPKRLKDKNALNILCKNGVHNGVVLKTNKLDIPYIKEVGHAENGEYKLAIEELDDAAAVDDDGEVKVKTKKVIRDDDIEQIEELYPLSLYLDEITDPQNMGSILRSAYFFGVDFIVVPNHSTAKLGPVANKASAGALDLIDIYQTGSSLKFIDSVRQNGWHVISTVVDQQVVQSLKKLPMLRMMSRMMPMSMLMLMLINHIKNKFIELQDLRTILKKTPVMLIIGSEGSGVRTNMKIRSDYLVGIPKIRRNDNIVDSLNAGVATGVILQNCLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YII4</accession>
    <name>C4YII4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_04259</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YII4"/>
    <dbReference type="PaxDb" id="5476-C4YII4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04259"/>
    <dbReference type="HOGENOM" id="CLU_010365_4_0_1"/>
    <dbReference type="OMA" id="GAPFHKY"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000046">
        <property type="entry name" value="Probable ferric reductase transmembrane component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0410">Iron transport</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="17">
        <location>
            <begin position="440"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ45919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="749" mass="85553" checksum="E787AE9EBC7DA94A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIJ1</accession>
    <name>C4YIJ1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_04267</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIJ1"/>
    <dbReference type="PaxDb" id="5476-C4YIJ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04267"/>
    <dbReference type="HOGENOM" id="CLU_024591_0_0_1"/>
    <dbReference type="OMA" id="WHGLMEL"/>
    <dbReference type="OrthoDB" id="1701437at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF4">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="262"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="350"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ45926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="420" mass="47410" checksum="98F8957458AB4D59" modified="2009-07-28" version="1">MIPISYPSPRVSQLDAGILDSELFSLLKEQLSSIFQLHSTSRYSFSQHSELYSLLLNLLIFRLTVWKSGSSYGSSLQNLKLTDSRSGKIIGSSRKALLGAVIIGGYLYKKLESYLFSLDESSTQNSHSTLDKLKNYLLINRTSILSGLENSLKIANLVNFTFFLVNGQYSSLVNRILGIIETPISSDLLKFNGSNVNYEFQNRQLVWNVMTEFLVFILPLLQLRKLGRMTRKLLGRSKNSLDVQSGNVPTLTSYTNLPVSECAICHDNNNQASQTGGRTFPSAGPVTNPYITNCGHVYCYVCISTRFNMIKVNGEDMPCLRCGKRLEWFEEFGLADGAVDEDAIVLSFENDESDEQEEESDEEGSITSEKEVHSYEPELSQNRIQRHLSERSTIFDDQSADEFSEDEYSEEEEFDADEMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIL1</accession>
    <name>C4YIL1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rxt3p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
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            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
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                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
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                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
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        </source>
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</entry>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ33</accession>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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                <person name="Grabherr M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="22 23">WO-1</strain>
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            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
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        </reaction>
    </comment>
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            <name>Cu cation</name>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cu-Zn superoxide dismutase family.</text>
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        <property type="entry name" value="SOD_Cu_Zn_dom"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="13" id="KW-0186">Copper</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 20" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012926295" description="superoxide dismutase" evidence="20">
        <location>
            <begin position="16"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="21">
        <location>
            <begin position="43"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="174"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="174"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EEQ45517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="232" mass="23726" checksum="CD945181DFC15842" modified="2010-10-05" version="1">MKYLSIISIVALALAGDSPISTDSKGKAPLVARFKKTSKSDIEGTIKFEPANNGTVLVSVDLTGLPSGVGPYPYHVHEKPVPESKNCTATGMHFNPFNGSTTAKTPAALELGDLSGRHGNITSESFEVEYDDSYISLNKDSKAYIGGLSIVVHSNNNTRLNCANITTLDEGDDTASAATWSNSSSSSSSSSKNSTNGSSGSSTSASQGSGAGRAEISGFLAAGIAGVVAALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ34</accession>
    <name>C4YJ34_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_03846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ34"/>
    <dbReference type="PaxDb" id="5476-C4YJ34"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03846"/>
    <dbReference type="HOGENOM" id="CLU_2346477_0_0_1"/>
    <dbReference type="OMA" id="CKSNTRF"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ45518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="97" mass="11799" checksum="CE65A4FC8527B6C6" modified="2009-07-28" version="1">MCKSNTRFKKGLIWYTMYKKVEQKKLFINQKQLIPNRDPNNHNTPEVCPIFYLLSHSNFECRFSQNVKKRHQFKKKTQKTDSLSTSYNQHFHYPIQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJA3</accession>
    <name>C4YJA3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="8">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_03916</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="8"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJA3"/>
    <dbReference type="SMR" id="C4YJA3"/>
    <dbReference type="PaxDb" id="5476-C4YJA3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03916"/>
    <dbReference type="HOGENOM" id="CLU_063339_1_0_1"/>
    <dbReference type="OMA" id="ITHFVYH"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000004">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="14">
        <location>
            <begin position="57"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00017366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ45587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="188" mass="20877" checksum="8CA335A0D1F675F6" modified="2009-07-28" version="1">MSDRVLEINALAKELKANLKQFPNFPKEGILFEDFLPIFTKPDLFNKLVKAFKLHVGEQKIDYVIGLESRGFLFGPTLALALNAGFVPVRKPGKLPGPTFKVEFQKEYGSDEFEIQQDVIPKGAKVLIVDDILATGGSAFGAGELAKKTGAEIVEYLFVMELDFLKGRDKLDAPVYTLFGGQEEKFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJW9</accession>
    <name>C4YJW9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJW9"/>
    <dbReference type="PaxDb" id="5476-C4YJW9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04140"/>
    <dbReference type="HOGENOM" id="CLU_1875167_0_0_1"/>
    <dbReference type="OMA" id="PQVDANS"/>
    <dbReference type="OrthoDB" id="4082192at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="114" mass="13013" checksum="51FB5F4CFA3714E0" modified="2009-07-28" version="1">MSADGKKEDNLETGEKIDGELQVKLGDKFFPISRFAKPHAVVHPADHHSKVDANKFPDVEPEQKQKEDLKEFNQQVLKPDINKPKVDPNSFPDIEPEAKEREAKLEAERLKKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK45</accession>
    <name>C4YK45_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Partial AB-hydrolase lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_05840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK45"/>
    <dbReference type="ESTHER" id="canal-q59u64">
        <property type="family name" value="Acidic_Lipase"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YK45"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05840"/>
    <dbReference type="HOGENOM" id="CLU_024238_2_0_1"/>
    <dbReference type="OMA" id="DAVEWCF"/>
    <dbReference type="OrthoDB" id="6130531at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000803">
        <property type="entry name" value="Steryl ester hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="3">
        <location>
            <begin position="107"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ47274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="567" mass="65545" checksum="397A50C2FAB453A5" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK64</accession>
    <name>C4YK64_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_05860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK64"/>
    <dbReference type="PaxDb" id="5476-C4YK64"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05860"/>
    <dbReference type="HOGENOM" id="CLU_030036_0_0_1"/>
    <dbReference type="OMA" id="HVHPKEM"/>
    <dbReference type="OrthoDB" id="10255128at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07599">
        <property type="entry name" value="BAR_Rvs167p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="554"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ47293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="624" mass="72760" checksum="6EA1354B31083014" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKB3</accession>
    <name>C4YKB3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_05910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKB3"/>
    <dbReference type="PaxDb" id="5476-C4YKB3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05910"/>
    <dbReference type="HOGENOM" id="CLU_017554_3_0_1"/>
    <dbReference type="OMA" id="VMIWIHV"/>
    <dbReference type="OrthoDB" id="6605928at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.10">
        <property type="entry name" value="subunit c (vma5p) of the yeast v-atpase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1180">
        <property type="entry name" value="Vacuolar atp synthase subunit c, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ47342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="388" mass="44675" checksum="6FE140C247D0263E" modified="2009-07-28" version="1">MSSNSVAKIAEYLILSLPQSTHAHEWLEQSLNNGKQPLYNLKIPDFQSGTLDSLVQESEELNKIDHQLGSSVNKVVEILNSINPQTSSGSSSSSSRIVQSRSIFDYIENFQWNSSKYRLDKPISQLVKMISQEAITLDNDVRTSYQSYQSAKSNFLAADRKKNGDLSIKSLHEIVKPEQFVLDSEHLTTILIAVPNNLLDDFHKNYETLTSFVIPRSAELIAKDQEFHLFTVTLFKKYQQEFINNAREHRWHPRTDFTYSEEILNELCKEFDLTQATELKLKNDLIRLTKTAYSDIMANWFHIKIIRTYVEAVLKYGLPPQFDNYLIKFNESNLKNVDKAKKELIAKFNYLGGNGYTTGNNNSSNLHEYASLVDTEYQPFVLYELEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKF8</accession>
    <name>C4YKF8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 8 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_05961</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKF8"/>
    <dbReference type="PaxDb" id="5476-C4YKF8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05961"/>
    <dbReference type="HOGENOM" id="CLU_000688_2_0_1"/>
    <dbReference type="OMA" id="REPAVIF"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000044">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="177"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="23"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ47387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="401" mass="44952" checksum="C975D65214E35E36" modified="2009-07-28" version="1">MTTSIDKSYVHEGGIRPYFEQQIQDTEIRIQQTTQNLRRLEAQRNKLNNKVRQLKDELRLLQEPGSYVGEVVKVMGLKKVLVKIHPEGKFIVNVTKDIDVKKLTPSIRVCLKADSHDLYKILPNKVDPLVSLMMVEKVPDSTYDMVGGLDKQIKEIKEVIELPVKHPELFESLGIAQPKGVILYGPPGTGKTLLARAVAHHTECKFIRVSGSELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRVEGSSGGDSEVQRTMLELLNQLDGFESSKDIKIIMATNRLDILDPALLRPGRIDRKIEFPAPTVAARTDILKIHSRSMNLTRGINLRKIAEKMNGCSGADVKGVCTEAGMYALRERRIHVTQEDFELAVAKVMSKNDDGAVSLQKLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKX1</accession>
    <name>C4YKX1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_06130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKX1"/>
    <dbReference type="PaxDb" id="5476-C4YKX1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06130"/>
    <dbReference type="HOGENOM" id="CLU_002351_2_0_1"/>
    <dbReference type="OMA" id="FEGHYKS"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000099">
        <property type="entry name" value="Alpha,alpha-trehalose phosphate synthase subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF15">
        <property type="entry name" value="TREHALOSE SYNTHASE COMPLEX REGULATORY SUBUNIT TPS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946586" evidence="5">
        <location>
            <begin position="17"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ47550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1007" mass="112278" checksum="8C66B2409FAD70FE" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL03</accession>
    <name>C4YL03_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3HC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_01517</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL03"/>
    <dbReference type="PaxDb" id="5476-C4YL03"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01517"/>
    <dbReference type="HOGENOM" id="CLU_615638_0_0_1"/>
    <dbReference type="OMA" id="GWKCVSF"/>
    <dbReference type="OrthoDB" id="3987180at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012935">
        <property type="entry name" value="NuBaID_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835">
        <property type="entry name" value="NUCLEAR-INTERACTING PARTNER OF ALK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835:SF6">
        <property type="entry name" value="ZINC FINGER C3HC-TYPE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07967">
        <property type="entry name" value="zf-C3HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C3HC-type" evidence="4">
        <location>
            <begin position="102"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ43284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="482" mass="56062" checksum="A2D6DCD1F84527BD" modified="2009-07-28" version="1">MEEIFKLTMDEPSENSAHISSTSQILQDCLSIIESPSHDSYKSSDSNSPVSTKNNNYSDHPDILYFQKIKQKNHFKFHKSKFQAKWNIDKVNSSKMNSNFDPYDLSSLLARLKTFNSLNWKSIDDSSINELKCAINGWKCVSFGVKETKNHLLCTYCNQQLILKFESNDLHNGNSTLVETPFDFQYLSGKTFDESFQKKLVELYIKQIENTGHEPNCLWKNFETPIEEVYHLRQYLPNTNQFLIQEYCKNLKNLIDNTLILQEYSDTFTSEFLQSQVNNDDFIHVSHEWLMAKFFRDNKENFSAGLAYNIPSWIYQLALHGWALNVQSYARDVILVMSCNMCNQRVFLNSDHSSNHQECSTHLKLSSSKILTPVKYAMSGTQNNDNTEFDTIVESKFDPRTQHKPWCAYLHNNLPAYFYQMLVQSKTNIGPVGEYIYDSSLMDIDTSIDSNQPPTRKRKNSFTVNEGLERLSKLRKLYLIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL19</accession>
    <name>C4YL19_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome quality control complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_01533</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NEMF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL19"/>
    <dbReference type="PaxDb" id="5476-C4YL19"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01533"/>
    <dbReference type="HOGENOM" id="CLU_003612_1_1_1"/>
    <dbReference type="OMA" id="MFLEFFA"/>
    <dbReference type="OrthoDB" id="207084at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.310.10:FF:000003">
        <property type="entry name" value="Zinc knuckle domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.310.10">
        <property type="entry name" value="ibrinogen binding protein from staphylococcus aureus domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021846">
        <property type="entry name" value="NFACT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11923">
        <property type="entry name" value="NFACT-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05833">
        <property type="entry name" value="NFACT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="8">
        <location>
            <begin position="567"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="NFACT protein C-terminal" evidence="9">
        <location>
            <begin position="889"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="439"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="738"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="993"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="825"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="477"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="754"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1005"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ43300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1018" mass="116561" checksum="7918789DF0F9EC23" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL65</accession>
    <name>C4YL65_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ER membrane protein complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_01580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane magnesium transporter (TC 1.A.67) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL65"/>
    <dbReference type="PaxDb" id="5476-C4YL65"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01580"/>
    <dbReference type="HOGENOM" id="CLU_132206_1_1_1"/>
    <dbReference type="OMA" id="STHYHTD"/>
    <dbReference type="OrthoDB" id="44756at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053279">
        <property type="entry name" value="EMC_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018937">
        <property type="entry name" value="MMgT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28144">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28144:SF1">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10270">
        <property type="entry name" value="MMgT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ43346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15837" checksum="0C109F976A329C3F" modified="2009-07-28" version="1">MSSSTHQYILYFVGTLLLVHSGYSSFEFHKISTHYHTDYRLPPLDIILESVIGIILLVIGSIVSIQNQPFLSIANDKHNMIIKNDFKYLRFIEMKDAVQLSEKIGITDYEEYNSRASFIDINQKRKEYNDWLEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL99</accession>
    <name>C4YL99_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbonic anhydrase</fullName>
            <ecNumber evidence="5">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_01616</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL99"/>
    <dbReference type="PaxDb" id="5476-C4YL99"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01616"/>
    <dbReference type="HOGENOM" id="CLU_084253_1_1_1"/>
    <dbReference type="OMA" id="ECGMSGL"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03379">
        <property type="entry name" value="beta_CA_cladeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175:SF3">
        <property type="entry name" value="CARBON DISULFIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ43380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="163" mass="17766" checksum="B12581CBA1A7F499" modified="2009-07-28" version="1">MSVAQEFEKANTHYSSNFTKGDLPLPPARKVAVVICMDARIDPAASLGLTEGDAHVIRNAGGRASDALRSVIISQRLLGTREIVVVHHTDCGMLTFSDNDLRGIIAKETGHNVDHFAFLPFGDLEKSVKDDVEFFKRNPLVLDVPVTGYIYDVKSGAINKVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLA2</accession>
    <name>C4YLA2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_01619</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLA2"/>
    <dbReference type="PaxDb" id="5476-C4YLA2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01619"/>
    <dbReference type="HOGENOM" id="CLU_013929_0_1_1"/>
    <dbReference type="OMA" id="KWINDGS"/>
    <dbReference type="OrthoDB" id="3057599at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="6">
        <location>
            <begin position="42"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="386"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="510"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="430"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ43383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="540" mass="61816" checksum="E7B7A486CE07F582" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLF7</accession>
    <name>C4YLF7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_01675</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="2"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLF7"/>
    <dbReference type="PaxDb" id="5476-C4YLF7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01675"/>
    <dbReference type="HOGENOM" id="CLU_001493_7_2_1"/>
    <dbReference type="OMA" id="HCWRCKT"/>
    <dbReference type="OrthoDB" id="10264412at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000400">
        <property type="entry name" value="Isoleucine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000290">
        <property type="entry name" value="Isoleucyl-tRNA synthetase (Mitochondrial)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02002">
        <property type="entry name" value="Ile_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023585">
        <property type="entry name" value="Ile-tRNA-ligase_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050081">
        <property type="entry name" value="Ile-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="52"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="11">
        <location>
            <begin position="729"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ43438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="973" mass="111625" checksum="3FFC7AAB0DE4A693" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLM3</accession>
    <name>C4YLM3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">mRNA export factor MEX67</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_01742</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the export of mRNA from the nucleus to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NXF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLM3"/>
    <dbReference type="PaxDb" id="5476-C4YLM3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01742"/>
    <dbReference type="HOGENOM" id="CLU_024991_1_1_1"/>
    <dbReference type="OMA" id="YGGHEAW"/>
    <dbReference type="OrthoDB" id="25872at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14342">
        <property type="entry name" value="UBA_TAP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000070">
        <property type="entry name" value="mRNA export factor MEX67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000296">
        <property type="entry name" value="mRNA export factor MEX67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040736">
        <property type="entry name" value="Mex67_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057125">
        <property type="entry name" value="NXF1/2/3/5-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005637">
        <property type="entry name" value="TAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24048">
        <property type="entry name" value="LRR_NXF1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22602">
        <property type="entry name" value="NXF_NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18444">
        <property type="entry name" value="RRM_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03943">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00804">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51281">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="12">
        <location>
            <begin position="309"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="TAP-C" evidence="13">
        <location>
            <begin position="565"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="513"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="445"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="526"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ43504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="617" mass="68284" checksum="D1062110FFD06AE0" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLT1</accession>
    <name>C4YLT1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Tubulin-specific chaperone A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_01800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Tubulin-folding protein; involved in the early step of the tubulin folding pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
            <location evidence="2 9">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TBCA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLT1"/>
    <dbReference type="SMR" id="C4YLT1"/>
    <dbReference type="PaxDb" id="5476-C4YLT1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01800"/>
    <dbReference type="HOGENOM" id="CLU_130569_2_0_1"/>
    <dbReference type="OMA" id="EECEMMI"/>
    <dbReference type="OrthoDB" id="296187at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000010">
        <property type="entry name" value="Tubulin-specific chaperone A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Tubulin chaperone cofactor A"/>
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    <keyword evidence="8 9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ43562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="95" mass="11059" checksum="297AB174450CEF75" modified="2009-07-28" version="1">MGPSPLQIKVNALKRLIKEEKLSKQEVAEQEQHINQMKANNADEYELKKQIQVLEESQRMVPEVTKKVAEYRQALKEFLDSYKGDEDVTEAKELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM34</accession>
    <name>C4YM34_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mhp1p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
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                <person name="Sherlock G."/>
                <person name="Shah P."/>
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                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="TGCCITD"/>
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    </dbReference>
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    <sequence length="1209" mass="134739" checksum="65654031B0E04B7F" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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    </protein>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
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                <person name="Sakthikumar S."/>
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                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
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                <person name="Brunke S."/>
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                <person name="Hube B."/>
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                <person name="Logue M.E."/>
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                <person name="Neiman A.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">WO-1</strain>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="427" mass="48947" checksum="FB6248DAFD7BC3C8" modified="2009-07-28" version="1">MTTSTPEKVAVSSQPVFPPLRAFDRAWSLTTDDSHIPVYDLLKLLHNLRLESLHDMHEDNELIHMDDMVIKSRIVEQTEFLHNVNKEQAYQIIYQSFYDAKEISKNTGSLNLQYDIFNNQYDSMIMMASNNGSQEDNDDEDYDETATLMEMTQNSPLQEDYEDILIPQQISNWVKPNIKLALTELEQFHIKLNNQYLGLENDLRQIKSKNDLDLKELQVLVGKNDHLISKLNDIRDELSGINNCLMEYRDQFDMDSFIACDNEKTKEWQSQLLNNNNDSNNNEELMVSCLQSIDVIEKEALEVDIKSSWSLDNTPLTTEIRISEKDHIFVSETKEATPDVQQVAETVPKTDNTSGIETADTVQKTSIIPIMSDNGSSDDIKESNLVKSHISNPNFTEIKKKGKLSKHSHYIVIVAIGVIFAYVKSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM81</accession>
    <name>C4YM81_CANAW</name>
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        <recommendedName>
            <fullName evidence="9">Bax inhibitor 1</fullName>
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    <organism evidence="7 8">
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            <taxon>Pichiomycetes</taxon>
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            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
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                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
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                <person name="Staggs R."/>
                <person name="Stansfield I."/>
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                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
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                <person name="Berriman M."/>
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                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <text evidence="5">Belongs to the BI1 family.</text>
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        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF50">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="73"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ43712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="29191" checksum="378C5E0A3F14C2A0" modified="2010-10-05" version="1">MSSYTELPQSAPPYSEGESGSPPRQFGDNIPDDFKYSVSVASCELPLRQLFIRKVYSLLTIQLMGSVIMGFIIRSSDSFKIWAMTNTWLLILSFIGSIGFMIGAFFKARSYPINLILLGGFTICESYTLGVACAFIESSILIEAILLTLIIFIGLTIFAFQTKYDFISWQGTVGMMLWGLIGWGFVMMFIPHQQNSMMENVYSFLGALIFSIYIIIDTQQIMKTLHLDDEIIGCISLYLDIINLFLFILRILNNNRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMC6</accession>
    <name>C4YMC6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Agglutinin-like protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_02005</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ALS family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMC6"/>
    <dbReference type="PaxDb" id="5476-C4YMC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02005"/>
    <dbReference type="HOGENOM" id="CLU_011374_0_0_1"/>
    <dbReference type="OMA" id="IIIHVET"/>
    <dbReference type="OrthoDB" id="3981162at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030446">
        <property type="term" value="C:hyphal cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030445">
        <property type="term" value="C:yeast-form cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043710">
        <property type="term" value="P:cell adhesion involved in multi-species biofilm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043709">
        <property type="term" value="P:cell adhesion involved in single-species biofilm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1280:FF:000001">
        <property type="entry name" value="Agglutinin-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2430:FF:000001">
        <property type="entry name" value="Agglutinin-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2430">
        <property type="entry name" value="Agglutinin-like protein, N-terminal domain, N2 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008440">
        <property type="entry name" value="Agglutinin-like_ALS_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024672">
        <property type="entry name" value="Agglutinin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043063">
        <property type="entry name" value="Agglutinin-like_N_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033504">
        <property type="entry name" value="ALS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011252">
        <property type="entry name" value="Fibrogen-bd_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793:SF2">
        <property type="entry name" value="AGGLUTININ-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793">
        <property type="entry name" value="ALPHA-AGGLUTININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05792">
        <property type="entry name" value="Candida_ALS"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11766">
        <property type="entry name" value="Candida_ALS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01056">
        <property type="entry name" value="Candida_ALS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="Bacterial adhesins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946869" description="Agglutinin-like protein N-terminal domain-containing protein" evidence="16">
        <location>
            <begin position="18"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="Agglutinin-like protein N-terminal" evidence="17">
        <location>
            <begin position="53"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ43757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="848" mass="92126" checksum="0EA4B4C405D8DC8C" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMV6</accession>
    <name>C4YMV6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMV6"/>
    <dbReference type="PaxDb" id="5476-C4YMV6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02193"/>
    <dbReference type="HOGENOM" id="CLU_015493_1_0_1"/>
    <dbReference type="OMA" id="ICGISCC"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF7">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="482" mass="55846" checksum="BC050EAE26640CDD" modified="2009-07-28" version="1">MSSQSPRFKRQRSKTGCKNCRLRKRKCDELHPTCTFCHTRDLICEYNEIKILNPTSFKPSKRIKKVQKNPSVSCSDLIPLTTDLHFPEPIFSPILNTNALSPLILYLDDQGIDYVRQFEQIASTLSLSQSTNYIKSTFLTLAFSNEAISNLLAAWGASHYGDSDDVNKYLMLAKGSIKNPHDRFDYFTTFACYLIQMAIYINTGDTQNWFQIFRKCETMIREYGGLIKFITDFQYSNDCKFLISNFQFYDVMSSESLERGTTCTMDKYLSLFKGRRILDETYGVDPYQGCCQPIYLLLGEIMNTYVELKKDRHNIVNCESVNVRVQYYKKVNEKVDHLIQSIDKCQPTPIPDGDGLQLKLFELCCIIGRMYVLLYIKQTQPKSSEIQLLLLDAISIIDELISTHLASNLSMALLMCGITCGNKYDRQNINGKFKIVYDKFRQGNLKRIWEIVKESWERNPLGNVCIDWLDICHDFNWKISMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMX2</accession>
    <name>C4YMX2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_02209</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMX2"/>
    <dbReference type="PaxDb" id="5476-C4YMX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02209"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="OMA" id="HLTWRWA"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF78">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="546"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="75"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ43953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="604" mass="66436" checksum="EF5BC72086986443" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN72</accession>
    <name>C4YN72_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_02312</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN72"/>
    <dbReference type="PaxDb" id="5476-C4YN72"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02312"/>
    <dbReference type="HOGENOM" id="CLU_489354_0_0_1"/>
    <dbReference type="OMA" id="IWLASNM"/>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="6">
        <location>
            <begin position="4"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="5">
        <location>
            <begin position="515"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ44053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="564" mass="63833" checksum="D77A9D8225E4DB94" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNB6</accession>
    <name>C4YNB6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_01372</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNB6"/>
    <dbReference type="PaxDb" id="5476-C4YNB6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01372"/>
    <dbReference type="HOGENOM" id="CLU_016855_0_0_1"/>
    <dbReference type="OMA" id="KMSYYNV"/>
    <dbReference type="OrthoDB" id="3367at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045013">
        <property type="term" value="P:carbon catabolite repression of transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF16">
        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="481"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="570"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="580"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ43149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="726" mass="81628" checksum="2BA4256DD1A3F4B7" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNC9</accession>
    <name>C4YNC9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNC9"/>
    <dbReference type="PaxDb" id="5476-C4YNC9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01388"/>
    <dbReference type="HOGENOM" id="CLU_127039_1_0_1"/>
    <dbReference type="OMA" id="TPEPPYY"/>
    <dbReference type="OrthoDB" id="10263341at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052936">
        <property type="entry name" value="Jasmonate_Hydroxylase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37811:SF2">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37811">
        <property type="entry name" value="BLL5343 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="24"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="109" mass="12513" checksum="63A53D94D7AE78A4" modified="2009-07-28" version="1">MSLATPPYYMVSFTSKLNSDIASDEYTQVADLMVSLAKQQPGFLGLESTRDPTSKIGITISYWKDKSSIQQWKQQSDHQLAQKLGKSKFYDYFKVRIALVERDYQFEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNE5</accession>
    <name>C4YNE5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BolA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNE5"/>
    <dbReference type="SMR" id="C4YNE5"/>
    <dbReference type="PaxDb" id="5476-C4YNE5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01404"/>
    <dbReference type="HOGENOM" id="CLU_109462_4_0_1"/>
    <dbReference type="OMA" id="VHAFSQK"/>
    <dbReference type="OrthoDB" id="4983at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045115">
        <property type="entry name" value="BOL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735:SF27">
        <property type="entry name" value="BOLA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735">
        <property type="entry name" value="BOLA-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="9655" checksum="C99BB0D03A9CC2DD" modified="2009-07-28" version="1">MSSSALTADSLRDIITTRLNANLVQVEDMSGGCGQAFAVIIVSSLFQGKNKLARHRLVNNELKDEIASIHAFTQKGFTPDEWIAQGGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNP9</accession>
    <name>C4YNP9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metacaspase-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_02831</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in cell death (apoptosis).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNP9"/>
    <dbReference type="PaxDb" id="5476-C4YNP9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02831"/>
    <dbReference type="HOGENOM" id="CLU_029389_0_1_1"/>
    <dbReference type="OMA" id="IRMALQW"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="9">
        <location>
            <begin position="147"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ44558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="448" mass="49282" checksum="C264F2215F0F9E0C" modified="2009-07-28" version="1">MFPGQGRHTYGGQQSNYSNQQQGYDQGYNQGYSQGYGQEYNQGYDRPSGPPPGQGQYNRPSGPPPGPPPGQGHYNRPSGPPPSQQGQYNRPSGPPPGQYGNNQTRGSGNEQNYGNMHGSGHYSRPPTDSQSFGVENYNYQYSNCSGRKKALLIGINYIGTKNELRGPINDVNNVEQFLLANGYSSDNIVKLTDDQRVQRAIPTRQNILDAIQWLVKDARPNDALFFHYSGHGGQTEDQPDEYGNYDEDDEYDEVIYPLDFETNGFIIDDLLHSMMVKTLPQGCRLTALFDSCHSGSVLDLPYMYSTKGVLKEPNVMKEAGAGLLQSAMAYATGDRSRMLSGLGGVVKTFMNQGKAEKANEYSKQTNTAPCDAISLSGCKDDQTSADSKENGTATGAMSYAFLTVMSQNPNQSYLSLLQNMREILSAKYSQKPQLSASHPIDTNLQFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP42</accession>
    <name>C4YP42_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein RMD9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YP42"/>
    <dbReference type="PaxDb" id="5476-C4YP42"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02980"/>
    <dbReference type="HOGENOM" id="CLU_019840_1_0_1"/>
    <dbReference type="OMA" id="WENGVND"/>
    <dbReference type="OrthoDB" id="4081443at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="70296" checksum="6EA8784E0AB13945" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPG8</accession>
    <name>C4YPG8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerol-1-phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_02367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPG8"/>
    <dbReference type="SMR" id="C4YPG8"/>
    <dbReference type="PaxDb" id="5476-C4YPG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02367"/>
    <dbReference type="HOGENOM" id="CLU_045011_13_4_1"/>
    <dbReference type="OMA" id="QVHTFDG"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000121">
        <property type="term" value="F:sn-glycerol 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006114">
        <property type="term" value="P:glycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006970">
        <property type="term" value="P:response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07527">
        <property type="entry name" value="HAD_ScGPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ44107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="28134" checksum="7552A357CAA97CC7" modified="2010-10-05" version="1">MTKTQQPAVFYVHAALFDCDGTLVNSTGAISEFWRDFGKTRPHVDPEEIIRTSHGCRTFDVIAKWSPEDAIEEQVTAWEGAIPDTFGHHAKPIPGSVELVKSFDKLSKEATENGKQRWAVVTSGTLPLATKWLKLLSIERPDCFITAEKVTKGKPHPQGYQAARDTLGYHDAHYKVVVFEDAPAGITAGKGAGAMVVGICSTYDPEKVRKSGANIVVKDLSSFRIDSYNKETDEFKVVVDDYFYADEQFLQESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPH5</accession>
    <name>C4YPH5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_02376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPH5"/>
    <dbReference type="PaxDb" id="5476-C4YPH5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02376"/>
    <dbReference type="HOGENOM" id="CLU_1488813_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ44115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="181" mass="20105" checksum="5DF5492D9F5E6ADE" modified="2009-07-28" version="1">MIGDITTSSSAIVGFVSASKMCNLIPIRKTNCLHVARMYDSILSQPITVSPFLVASLTVKKNPGNPPMSDQERIDPVRKIPCNLENLTSDPNVLTTLWVPSGTFPKRYSNPFLVVKHIRGLVVSSVKCVIVVTLNISVPFETGLFGVLGLLSWVLQVCRWYFPECIKLVENKERLEKGKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPH7</accession>
    <name>C4YPH7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Telomere replication protein EST3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_02378</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the telomerase complex involved in telomere replication. Stimulates RNA/DNA heteroduplex unwinding which favors the telomere replication by the telomerase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the EST3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPH7"/>
    <dbReference type="PaxDb" id="5476-C4YPH7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02378"/>
    <dbReference type="HOGENOM" id="CLU_1354578_0_0_1"/>
    <dbReference type="OMA" id="ADSTHKI"/>
    <dbReference type="OrthoDB" id="4083059at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019437">
        <property type="entry name" value="TPP1/Est3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10341">
        <property type="entry name" value="TPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0779">Telomere</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946909" description="Telomere replication protein EST3" evidence="9">
        <location>
            <begin position="23"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Shelterin complex subunit TPP1/Est3" evidence="10">
        <location>
            <begin position="34"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ44116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="210" mass="24286" checksum="ABB19BE243B9A986" modified="2009-07-28" version="1">MFRSVSLSSLIPFLIIVSIAMQRPENDVPMIMQSSWLINEVIKSINSNGQYINALIKKDFQPTVLPVSFILRILKFTATTDSKDITAVLADSTHKIFAIFLFSPAIVDFENKYHHRMTYNTRSCLIRIHKANLKFMDKSTVKKCYGRKSDGGLAIAVLEVLEFDIFFKDQYSFINSIENRLKYVYDDAEYNQLCGEKKHKPEYEDLMCDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPJ4</accession>
    <name>C4YPJ4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hyphally-regulated cell wall protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_02395</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPJ4"/>
    <dbReference type="PaxDb" id="5476-C4YPJ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02395"/>
    <dbReference type="HOGENOM" id="CLU_006199_3_1_1"/>
    <dbReference type="OMA" id="ANGSHKI"/>
    <dbReference type="OrthoDB" id="4022214at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025928">
        <property type="entry name" value="Flocculin_t3_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021031">
        <property type="entry name" value="Hyphal-reg_cell_wall_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13928">
        <property type="entry name" value="Flocculin_t3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11765">
        <property type="entry name" value="Hyphal_reg_CWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944370" description="Hyphally-regulated cell wall protein N-terminal domain-containing protein" evidence="7">
        <location>
            <begin position="19"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Hyphally-regulated cell wall protein N-terminal" evidence="8">
        <location>
            <begin position="15"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="349"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="349"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ44133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="511" mass="53516" checksum="9AFAAAEC2098BEB2" modified="2009-07-28" version="1">MLLSNLVIPLLATRATVSATFDVTSSLTKYAAFDFGVGDISIQKSASFSLINTFDCAFQGDINIEKDCEFLIASTAKALKLTFNNIFHKIENKGKWIVHTLESAAASTCNIIVKSFVNTGEIILAFKGHVLAPIINITASHWVNHGCLHLFQEIKSISVAILGVVGGTIENHGTICLTNQLCKQVTKIIGSGCIALEKSSSFFISNSFLSIDAQHTFYLGEGNPTIQAQAVSLPQTFKVANFGANGSHKIGLNLPLLSITIAGKKGWSYDTKTGILTLTANGFISQKFDIGLGYDPSKFEVCTDNSVGIVSVIKGSIKYNGPCPHAGRPSVCQICPDVPTPPVITSSATAITSTQSKTTSSSSTSSIATTSTTSSKPKPTTVSTSSIASTTTPDGSYSTSFVTVTAETTKVVTITSCSNNACHPTTAPTGLTVVTLTTSDVKTVVTTYCPLTQTVTLGVTGTKTVDLGCPTGYFGYNGYIGKGVSIGHGGAAASASAGFQIGFDIFKNHHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPR5</accession>
    <name>C4YPR5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_02467</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPR5"/>
    <dbReference type="PaxDb" id="5476-C4YPR5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02467"/>
    <dbReference type="HOGENOM" id="CLU_034486_0_0_1"/>
    <dbReference type="OMA" id="SWRMTTP"/>
    <dbReference type="OrthoDB" id="3364892at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF26">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="198"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ44204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="459" mass="52058" checksum="F17BC70BD4A03704" modified="2009-07-28" version="1">MNHNNNTYHGGSSTPPQTTELCNLLNCFLSHPIYNDSTLLLNDNSQKKNNTSTTSNQTVSLSAAGMRALIYQLQSIYLRTPIKLFRPSRFDYLAYVRALANKHDNIENKPYRFMTHSSLGMVINVVRKQGWKFIPDQILPPLIANSATGVILYATYLTTLDYYTKQHEKNKVESHTTTSGGGGGTATTTTSRANFNWYAPIDTWRAGFVAGAVQSLAAAPVDAIYTRSTVAEMLEGSHENLWVFGFNKLREIGLIGVFAGYGFSLVKESFGFAFYFSTFEIIKTQGYNLTYKLINYYKRSEQLIKSNLKKIFHWDDDKIDEKLEKLEKYRSMKILKSSFILIAGASAAFSLLAVQYPISKVQKIHLSRLEALDVYNASRFVGNTSPFFKLYYNSYVDTYKQVLRMKQRANITWFEAAYSGFVRNALTTIPATSIALLVFEIMRTKLSDNFEDYNDVLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ71</accession>
    <name>C4YQ71_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_02626</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ71"/>
    <dbReference type="PaxDb" id="5476-C4YQ71"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02626"/>
    <dbReference type="HOGENOM" id="CLU_053380_4_0_1"/>
    <dbReference type="OMA" id="GKLMYGM"/>
    <dbReference type="OrthoDB" id="3364529at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000028">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ44360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="160" mass="18543" checksum="7DC2D85A716C18F9" modified="2009-07-28" version="1">MTIYSFFIFDRHCNCIYNREYTHTASSNDTLSGQINKSNDSNSSKLLFGILYSLKTISNKLANDEETEMNELKSFTIGSFKVHFWESLSRFKFVIVTNGEVSQLSDVLFELYSNYFIKYVVKNGLMPVEFTAEGEYSKINNGKFIEETDNYLQSLSIFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQG5</accession>
    <name>C4YQG5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b-c1 complex subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Complex III subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_02723</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQG5"/>
    <dbReference type="PaxDb" id="5476-C4YQG5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02723"/>
    <dbReference type="HOGENOM" id="CLU_115913_0_0_1"/>
    <dbReference type="OMA" id="NEDCVEE"/>
    <dbReference type="OrthoDB" id="405848at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.20:FF:000003">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003422">
        <property type="entry name" value="Cyt_b-c1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="12">
        <location>
            <begin position="66"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="19"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ44454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="137" mass="16318" checksum="97D66871BFC6B85A" modified="2009-07-28" version="1">MSFFRDLLESVVPTAYAEEVFEDVEVEQPEDAPEEEVSEETVEEEEDDDEEDDEDDEDEEEEETADPLDTLREECTKTAACKPFDHHFHECIERVTKEQEEPDYEHKHYKEDCIEEFFHLQHCVNDCVAPRLFNRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQK6</accession>
    <name>C4YQK6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Phosphoribosylaminoimidazole carboxylase</fullName>
            <ecNumber evidence="4 11">4.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_02765</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2</text>
            <dbReference type="Rhea" id="RHEA:10792"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.21" evidence="4 11"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQK6"/>
    <dbReference type="PaxDb" id="5476-C4YQK6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02765"/>
    <dbReference type="HOGENOM" id="CLU_011534_2_1_1"/>
    <dbReference type="OMA" id="PANVKWK"/>
    <dbReference type="OrthoDB" id="15425at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000013">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000030">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000016">
        <property type="entry name" value="phosphoribosylaminoimidazole carboxylase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000037">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016301">
        <property type="entry name" value="Ade2_fungi/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054350">
        <property type="entry name" value="PurT/PurK_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004679">
        <property type="entry name" value="PRK06019.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609:SF5">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609">
        <property type="entry name" value="PURINE BIOSYNTHESIS PROTEIN 6/7, PUR6/7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22660">
        <property type="entry name" value="RS_preATP-grasp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001340">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="110"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ44495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="568" mass="62380" checksum="C2F227C1E2D844DE" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQP7</accession>
    <name>C4YQP7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyldiphosphate specific]</fullName>
            <ecNumber evidence="5">2.5.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_02806</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate</text>
            <dbReference type="Rhea" id="RHEA:53008"/>
            <dbReference type="Rhea" id="RHEA-COMP:19494"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:136960"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.87" evidence="5"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQP7"/>
    <dbReference type="PaxDb" id="5476-C4YQP7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02806"/>
    <dbReference type="HOGENOM" id="CLU_051870_0_0_1"/>
    <dbReference type="OMA" id="AWSSCAG"/>
    <dbReference type="OrthoDB" id="19639at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038887">
        <property type="entry name" value="Nus1/NgBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528:SF0">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ44536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="349" mass="40148" checksum="BEEF2D3DDB586AFB" modified="2009-07-28" version="1">MNVTSPKISENVRLRNNGNTQLKNITRDMNNNDNESNEDSETKAPPNSYRIYNIFSIILALFRSLIKTTSKTTNSVFQMSMFYINHFILLSLFFMIAIYKNFQYLYRRVYLKYLAVTYYPSKSPQVIREDINKLEKIPKIVSCILDLQDDEDENGGKDGLINSISELTAWSMSAGLTKLIIYEFTGALIENSGCIVDLRKYITKTLVLYFGTEAIPTFSIRIPHKNLIIYSDNHIDSNAVDLEIDLISRIDGKPTLVELTKTMSELAVNRELSIRDITIDLIDEELHELVGPEPDLLISFAPSLNLEDYPPWHIRLSEIYWEPDNKDVNYAVFLRGLQQFSNCKINIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQP8</accession>
    <name>C4YQP8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 16">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_02807</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="function">
        <text evidence="16">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQP8"/>
    <dbReference type="SMR" id="C4YQP8"/>
    <dbReference type="PaxDb" id="5476-C4YQP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02807"/>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
    <dbReference type="OMA" id="HYYANTN"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 16" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ44537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="181" mass="20574" checksum="350CFBC1DC3DE61C" modified="2010-10-05" version="1">MGLSFSKLFANLFGNKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRYYFQNTQGIIFVVDSNDRDRIAEAREELQQMLNEDELRDALLLVFANKQDLPNAMNAAEITEKLGLHSIRQRPWYIQATCATTGDGLYEGLEWLSTNLKNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQZ5</accession>
    <name>C4YQZ5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQZ5"/>
    <dbReference type="PaxDb" id="5476-C4YQZ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04492"/>
    <dbReference type="HOGENOM" id="CLU_076902_9_1_1"/>
    <dbReference type="OMA" id="THTSIFG"/>
    <dbReference type="OrthoDB" id="368909at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06168">
        <property type="entry name" value="LSMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034110">
        <property type="entry name" value="LSMD1_Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="5"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="91" mass="10023" checksum="EE1A15E33A6830CB" modified="2009-07-28" version="1">MTTSLSPDKFIGANLHVKLSDSRILEGILTVIDPFGNLLLSNVYETSIDKLNDKQSHVREIGLVSVPRESIESIKTDKKTHTSIFGVEGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR27</accession>
    <name>C4YR27_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR27"/>
    <dbReference type="PaxDb" id="5476-C4YR27"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04526"/>
    <dbReference type="HOGENOM" id="CLU_122019_0_0_1"/>
    <dbReference type="OMA" id="KCIQVNC"/>
    <dbReference type="OrthoDB" id="4023582at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742:SF3">
        <property type="entry name" value="RIBONUCLEASE MRP PROTEIN SUBUNIT SNM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="202" mass="23012" checksum="E032EDA765ECFC44" modified="2009-07-28" version="1">MKQATNSLEGSLPARSPTTTTTASESKTKPTKAPVPKKPLNQSESKLIHLYNLAHSKIDSPFSKLYSLLYHKQEEQQTQTLPDSVLKKFCLKCGNLFIPGLTVSVRVVYTKQKIRKLRTRCLACRHSVFDDGLIQKQEKVEPIVKPAVVQSTNEENNVNNSKSKERRKKRKMNSLSNLLQDKKKKKTEESKLNSLDLMEFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR34</accession>
    <name>C4YR34_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Topoisomerase 1-associated factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_04533</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the timeless family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR34"/>
    <dbReference type="PaxDb" id="5476-C4YR34"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04533"/>
    <dbReference type="HOGENOM" id="CLU_008440_0_0_1"/>
    <dbReference type="OMA" id="VNHHRHT"/>
    <dbReference type="OrthoDB" id="310853at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006906">
        <property type="entry name" value="Timeless_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF4">
        <property type="entry name" value="PROTEIN TIMELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04821">
        <property type="entry name" value="TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Timeless N-terminal" evidence="11">
        <location>
            <begin position="97"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1042"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1178"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1060"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1179"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1211"/>
            <end position="1236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ46187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1263" mass="144882" checksum="FF1E042DECEE49FE" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR46</accession>
    <name>C4YR46_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Elongation factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_04545</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR46"/>
    <dbReference type="SMR" id="C4YR46"/>
    <dbReference type="PaxDb" id="5476-C4YR46"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04545"/>
    <dbReference type="HOGENOM" id="CLU_002848_0_0_1"/>
    <dbReference type="OMA" id="VLSEAMW"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1390.20:FF:000001">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000001">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040533">
        <property type="entry name" value="EF3_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047036">
        <property type="entry name" value="EF3_4HB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF5">
        <property type="entry name" value="ELONGATION FACTOR 3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17947">
        <property type="entry name" value="4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 16" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="repeat" description="HEAT" evidence="13">
        <location>
            <begin position="174"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="429"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="672"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="980"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1013"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEQ46199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1050" mass="116939" checksum="B73F312FC4148D79" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR50</accession>
    <name>C4YR50_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar-sorting protein SNF8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_04549</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SNF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR50"/>
    <dbReference type="PaxDb" id="5476-C4YR50"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04549"/>
    <dbReference type="HOGENOM" id="CLU_070147_0_1_1"/>
    <dbReference type="OMA" id="QIVEVCM"/>
    <dbReference type="OrthoDB" id="283883at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000397">
        <property type="entry name" value="Vacuolar-sorting protein SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017215">
        <property type="entry name" value="ESCRT2_Vps22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ46203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="254" mass="28852" checksum="6B7BC016C734803D" modified="2009-07-28" version="1">MNHSNTTNTDRDAYLQLGKSLNEQHSNQLSTQLQVFQSALINFANDHGDEISSNLEFKNKFTQIVQSIGIDPLDLLLYTSQNDRNGGTSSSSNYKRSNVVATNFGVALAVKIIEICQQTRDLNGGLISLKELISTLQNSCETEGISLVISEKDIESSLNNLNTLGKGYEILIINGKKWLKFSSTENLSNDQLKIYELCEFMGGYVTYRLLRDNYGWDKVRYKTVIDEMIMNGFLWVDSQDNGEWQYWEPSWISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRD7</accession>
    <name>C4YRD7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRD7"/>
    <dbReference type="PaxDb" id="5476-C4YRD7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04636"/>
    <dbReference type="HOGENOM" id="CLU_1586252_0_0_1"/>
    <dbReference type="OMA" id="INFIERG"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="158" mass="18473" checksum="504CDB627084D8F0" modified="2009-07-28" version="1">MMTKICHRINLLPIIAKRDGLTDIELIQCKHAINRDISENKIQIFNFLSKSNADADHHYKRDGDIEEYMTLSAKEYNYLSELNKSIPFAIIGSNSIVGDPQNEIVRNTKWGSIQIEDKNICDFKILKNIIFETHLQEFKDVTVEKIYEKFRVEQLIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRI6</accession>
    <name>C4YRI6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRI6"/>
    <dbReference type="PaxDb" id="5476-C4YRI6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04686"/>
    <dbReference type="HOGENOM" id="CLU_993952_0_0_1"/>
    <dbReference type="OMA" id="DNTYTRR"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946960" evidence="2">
        <location>
            <begin position="19"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="271" mass="25738" checksum="9571A76B529F7E8A" modified="2009-07-28" version="1">MQFSTLVSLAAVIVSTNAAALLTQTVESSTVVTITSCGPEHTNCPASSPATPAPAPSASAPAPPAPEQPEPSAPAPAPSAPAPEQPEQPATPATPAAPATPATPAAPEPSAPAPEQPASPATPEQPAAPATPATPAAPEPSAPAPEQPASPAAPAPAPSAPAPAPEQPEQPAAPTTKEAESTPAPAPSAPAPPAPEQPESAPAPAPSAPAPEQPESSPAPAPSAPASVPEQPASSVSNSTGPSSVPTFEGAAAKQYITGSVAVIAAALLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRL1</accession>
    <name>C4YRL1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b-c1 complex subunit 2, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Complex III subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Core protein II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquinol-cytochrome-c reductase complex core protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_04711</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRL1"/>
    <dbReference type="PaxDb" id="5476-C4YRL1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04711"/>
    <dbReference type="HOGENOM" id="CLU_009902_0_1_1"/>
    <dbReference type="OMA" id="YKYQDAG"/>
    <dbReference type="OrthoDB" id="6369905at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000021">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF209">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="14">
        <location>
            <begin position="43"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="15">
        <location>
            <begin position="167"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEQ46364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="374" mass="39586" checksum="30018DF7D1969676" modified="2009-07-28" version="1">MLSRASIRAYSSIPNSVKIAAKESATDLTKLSVIINNAGSKTGKSGVSHLLSKFTFLNNGAKSALRFTRESELLGGTFESKVTRDALILNTTFLKQDLPYYVEALGNVVSNTQFAPHEFNEIVLPTANAETKLANANPAFKGVEKLHEITFRRGLGNPLFYNESTPIKLEEVAQFSKEQFSGENISIVAEGANEEDLTKFVSESAFCYLPSSSSNGAKALPTNTFTGQEARVPSSGASSALIGIPVKPADFGKYEVLSAAIGTSTLPSTSTPLAQIPGATSHLYKYQDAGLFVISVSGEASQVAQGIKQAKSVAESVSSSALSEAVKAAELSVALQSTVDSPLNVKVVAEEVPISKFNYVAVGDLDVLPYADEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRM5</accession>
    <name>C4YRM5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_04727</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRM5"/>
    <dbReference type="SMR" id="C4YRM5"/>
    <dbReference type="PaxDb" id="5476-C4YRM5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04727"/>
    <dbReference type="HOGENOM" id="CLU_129470_4_0_1"/>
    <dbReference type="OMA" id="RIVHHSG"/>
    <dbReference type="OrthoDB" id="10263513at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ46378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="105" mass="11609" checksum="D44DB2C1A4D9D552" modified="2010-10-05" version="1">MAPKVQQTKAAKAAAALAGGKKGKKKWNKGKVKDKAQHIVILDQEKYDRILKDVPTYKYVSVSVLVDRLKIGGSLARVALRQLEEDGIITPVLKHSKQAIYTRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRX8</accession>
    <name>C4YRX8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphatidylserine decarboxylase proenzyme 2</fullName>
            <ecNumber evidence="11">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="11">Phosphatidylserine decarboxylase 2 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="11">Phosphatidylserine decarboxylase 2 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="11" type="primary">PSD2</name>
        <name evidence="14" type="ORF">CAWG_04836</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="11">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit. Interacts with pstB2. This interaction may be a means to structurally tether the donor membrane (ER) harboring PstB2 to acceptor membranes (Golgi/endosomes) harboring PSD2 during PtdSer transport to the site of PtdEtn synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Golgi apparatus membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Endosome membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The C2 domains have an essential, but non-catalytic function. They may facilitate interactions with other proteins and are required for lipid transport function.</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="11"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRX8"/>
    <dbReference type="PaxDb" id="5476-C4YRX8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04836"/>
    <dbReference type="HOGENOM" id="CLU_002661_0_0_1"/>
    <dbReference type="OMA" id="TCASRDW"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04039">
        <property type="entry name" value="C2_PSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000399">
        <property type="entry name" value="Phosphatidylserine decarboxylase proenzyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00663">
        <property type="entry name" value="PS_decarb_PSD_B_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033179">
        <property type="entry name" value="PSD_type2_pro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="11" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10 11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023265213" description="Phosphatidylserine decarboxylase 2 beta chain" evidence="11">
        <location>
            <begin position="1"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023265214" description="Phosphatidylserine decarboxylase 2 alpha chain" evidence="11">
        <location>
            <begin position="956"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="12"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="315"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="432"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="11">
        <location>
            <position position="814"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="11">
        <location>
            <position position="869"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="11">
        <location>
            <position position="956"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="11">
        <location>
            <position position="956"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="11">
        <location>
            <begin position="955"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="11">
        <location>
            <position position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ46481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1070" mass="121624" checksum="F667D40767164BC3" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRZ0</accession>
    <name>C4YRZ0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRZ0"/>
    <dbReference type="PaxDb" id="5476-C4YRZ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04848"/>
    <dbReference type="HOGENOM" id="CLU_2263362_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946754" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="12259" checksum="BBEF529AA7663DF5" modified="2010-10-05" version="1">MILVCIALFWFALFLQLCDSLNCFAISCLDYCTNFFLTVNYFFNEFTKKKQNTKELNANNSYIILGLYACILFKRTYNTCLLYRNLKLSTCFLLFLRYLSRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS73</accession>
    <name>C4YS73_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Lipase</fullName>
            <ecNumber evidence="12">3.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_04932</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:12045"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the AB hydrolase superfamily. Lipase family. Class Lip subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="12"/>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS73"/>
    <dbReference type="SMR" id="C4YS73"/>
    <dbReference type="ESTHER" id="canal-LIP4">
        <property type="family name" value="Fungal-Bact_LIP"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YS73"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04932"/>
    <dbReference type="HOGENOM" id="CLU_029538_5_0_1"/>
    <dbReference type="OMA" id="GINGIAH"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.130:FF:000001">
        <property type="entry name" value="Lipase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR029171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ46576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="459" mass="49580" checksum="D38354ADB6FE1F5D" modified="2010-10-05" version="1">MLFLLFLLVAPIYAGLILPTKPSNDPFYNAPAGFEKAAVGEILQSRKTPKPITGVFVPVKIQNSWQLLVRSEDSFGNPNVIVTTVMEPFNADPSKLASYQVFEDSAKADCAPSYALQFGSDVTTIATQVETYLLAPLLDQGYYVVSPDYEGPKSTFTVGKQSGQAVLNSIRAALKSGKITNLAEDAKVVMWGYSGGSLASGWAAALQPNYAPELGGNLLGAALGGFVTNITATAEATDGTVFAGIMANALGGVANEYPEFKQILQNDTDKQSVFDQFDNHCLADGVINYIGKHFLSGTNKIFKSGWNILKNPTISKIVEDNGLVYQKQLVPKIPILIYHGAIDQIVPIVNVKKTYQNWCDAGIASLEFSEDATNGHITETIVGAPVALTWIINRFNGKQTVSGCQHVKRTSNFEYPNIPPSILNYFKAALNILIQKGLGPDIQKDQVNPDGLKKIPILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSB1</accession>
    <name>C4YSB1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">E3 ubiquitin-protein ligase listerin</fullName>
            <ecNumber evidence="5 16">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">RING-type E3 ubiquitin transferase listerin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_04973</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Mediates ubiquitination of proteins derived from mRNAs lacking stop codons (non-stop proteins) and other translation arrest products induced by poly-lysine sequences and tandem rare codons. Ubiquitination leads to CDC48 recruitment for extraction and degradation of the incomplete translation product. May indirectly play a role in chromatin function and transcription.</text>
    </comment>
    <comment type="function">
        <text evidence="16">E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the ribosome quality control complex (RQC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the LTN1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 16"/>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSB1"/>
    <dbReference type="PaxDb" id="5476-C4YSB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04973"/>
    <dbReference type="HOGENOM" id="CLU_015885_0_0_1"/>
    <dbReference type="OMA" id="DISKEGM"/>
    <dbReference type="OrthoDB" id="6108at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16491">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000038">
        <property type="entry name" value="E3 ubiquitin-protein ligase listerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054477">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054478">
        <property type="entry name" value="LTN1_UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039804">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LISTERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="ZINC FINGER PROTEIN 294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22999">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23009">
        <property type="entry name" value="UBC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01197">
        <property type="entry name" value="FANCL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="825"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ46614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="878" mass="101835" checksum="5F831C2965AB2C86" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSL0</accession>
    <name>C4YSL0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSL0"/>
    <dbReference type="PaxDb" id="5476-C4YSL0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05078"/>
    <dbReference type="HOGENOM" id="CLU_2305673_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946974" description="Secreted protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="11467" checksum="97A5CEB5B2E523CE" modified="2009-07-28" version="1">MVVCMVFFIGEFQVLCTNCKFLYACIKKGTTQTIVHQSVRFCVLQNAIKPLYYYNLKQKKKKKFTKNKSFYFFFHLRQFLVWGNFFQSISGGSSSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSV4</accession>
    <name>C4YSV4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_05173</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSV4"/>
    <dbReference type="SMR" id="C4YSV4"/>
    <dbReference type="PaxDb" id="5476-C4YSV4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05173"/>
    <dbReference type="HOGENOM" id="CLU_053371_0_0_1"/>
    <dbReference type="OMA" id="GQPWFSD"/>
    <dbReference type="OrthoDB" id="409947at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001409">
        <property type="term" value="F:guanine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000010">
        <property type="entry name" value="Probable YHM1 (Mitochondrial carrier)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053042">
        <property type="entry name" value="Mito_GTP/GDP_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974">
        <property type="entry name" value="MITOCHONDRIAL GTP/GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974:SF1">
        <property type="entry name" value="MITOCHONDRIAL GTP_GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="122"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="215"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ46807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="304" mass="33191" checksum="FF26DAAB66C44DF4" modified="2009-07-28" version="1">MSPAAQSSSDKKQSGIARVLGSATAGIAEIGVFHPVDTISKRLMSNHTKVTSLHELNKVIFRDQASQALGKRLFSLFPGLGYAACYKILQRVYKYGGQPFANEFLTKNFKDTYDAAFGPKTGKALMSATAGSLIGIGEVVLLPLDVLKIKRQTNPESFRGRGFLKIIQDEGLGLYRGWGWTMARNAPGSFALFGGNSFAKEYIFGLKDYSQATWSQNFITSIFGASASLIVSAPLDVIKTRIQNRNFENPESGFTILKNMFKNEGITAFFKGLTPKLLTTGPKLVFSFALAQSLIPAFDKLLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSV5</accession>
    <name>C4YSV5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSV5"/>
    <dbReference type="PaxDb" id="5476-C4YSV5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05174"/>
    <dbReference type="HOGENOM" id="CLU_015606_1_0_1"/>
    <dbReference type="OMA" id="ARSDFAN"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16982">
        <property type="entry name" value="CID_Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000078">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045154">
        <property type="entry name" value="PCF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054127">
        <property type="entry name" value="Pcf11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047415">
        <property type="entry name" value="Pcf11_CID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021605">
        <property type="entry name" value="Pcf11_Clp1-ID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921:SF3">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21936">
        <property type="entry name" value="Pcf11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11526">
        <property type="entry name" value="Pfc11_Clp1_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="525" mass="59497" checksum="77F8E447F5576B2F" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSX9</accession>
    <name>C4YSX9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSX9"/>
    <dbReference type="PaxDb" id="5476-C4YSX9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05674"/>
    <dbReference type="HOGENOM" id="CLU_025280_0_0_1"/>
    <dbReference type="OMA" id="RWKSIHD"/>
    <dbReference type="OrthoDB" id="4085918at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ47115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="653" mass="73747" checksum="11ADC03957A2493E" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT41</accession>
    <name>C4YT41_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_05740</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT41"/>
    <dbReference type="PaxDb" id="5476-C4YT41"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05740"/>
    <dbReference type="HOGENOM" id="CLU_000288_109_1_1"/>
    <dbReference type="OMA" id="AMHQYKV"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001663">
        <property type="entry name" value="Putative serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000860">
        <property type="entry name" value="Serine/threonine-protein kinase ENV7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052239">
        <property type="entry name" value="Ser/Thr-specific_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998:SF2">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="30"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ47177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="362" mass="41001" checksum="8A84CACE50FB0524" modified="2009-07-28" version="1">MDVLLSIFGTCLPCFPTLSSPSIIINNNKYRIIRLLGEGGFSYVYLVSSQSQPSSQYALKKIRCPYGIQDESFKNAVREIKNYHRFKSPYIISSIDELIQSETDGSKNIYILLPFFQKSLQDIINELVLNNSKMEESEILRVFIGTCRGLKVMHNHKKTATSTTRLDDDEQDVLLPTSEDDEYEDFTNSTDNNNNVQMQELVPFAHHDLKPANVMLSAEGLPVLCDLGSCSRARISVRNRQQALTVQEFAQEHCTLPYRAPELVDVATNCEITEKTDIWSLGCLLYCCCFGYSPFEKLEIEQGANLNLAILQGKYEIPKGNNGYDSKLIELIKKCLQLNPDSRPDIDELLNDVLELTRQLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTD0</accession>
    <name>C4YTD0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_05417</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTD0"/>
    <dbReference type="PaxDb" id="5476-C4YTD0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05417"/>
    <dbReference type="HOGENOM" id="CLU_011220_3_0_1"/>
    <dbReference type="OMA" id="FHFEYDM"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF4">
        <property type="entry name" value="SPORULATION PROTEIN RMD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="374"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="107"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ46871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="596" mass="67662" checksum="52AC0AF1A5F0ED4F" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTL2</accession>
    <name>C4YTL2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Purine nucleoside permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_05507</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Nucleoside permease that transports adenosine and guanosine. Does not show any transport activities towards cytidine, adenine, guanine, uridine, and uracil.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the NUP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTL2"/>
    <dbReference type="PaxDb" id="5476-C4YTL2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05507"/>
    <dbReference type="HOGENOM" id="CLU_031475_0_1_1"/>
    <dbReference type="OMA" id="WAHYLVE"/>
    <dbReference type="OrthoDB" id="2331083at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000023">
        <property type="entry name" value="Purine nucleoside permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009486">
        <property type="entry name" value="Pur_nuclsid_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643:SF1">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06516">
        <property type="entry name" value="NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013171">
        <property type="entry name" value="Pur_nuclsid_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946777" description="Purine nucleoside permease" evidence="7">
        <location>
            <begin position="23"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00058783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR013171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ46953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="406" mass="44878" checksum="1990C3F8322EF560" modified="2009-07-28" version="1">MKLSTLFTLATTISTLTTFTIANPVVVVEKRAINETALAEDIPTTKNNHAQTSYGKPFSIYQPKAFIISMFSLERDPWLKAMDFVHNITIPGLSPVYPDIHCTTNYTICQITTGEGEINAASSISALTLNPLFDLTKTYFLVGGIAGGEPNYTTIGGVTFAKYAVQVGLEYQLAYEDYHKTNPDWISGYIPYGTDDQNTYPGNVYGTEVFEVNEKLRDRAVELASKAHLNNGTEGNAKFRKLYNETAAQGLPKVVKCDSLTSDNYFTGNVLNDYFANFTLLMTNGSATYCSTAQEDNATLEVMTRLAKHGLVDYDRIMIMRTISDFSRPPPSMSAYEYFFNRSDGGISASLENLVIAGTPIIHDIVQNWDKIYESGEKYSSKNYVGDIFATLGGKPDFGKESFDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTN2</accession>
    <name>C4YTN2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Iron-sulfur cluster assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_05527</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTN2"/>
    <dbReference type="PaxDb" id="5476-C4YTN2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05527"/>
    <dbReference type="HOGENOM" id="CLU_079283_1_2_1"/>
    <dbReference type="OMA" id="SMVTEMV"/>
    <dbReference type="OrthoDB" id="1925777at2759"/>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000005">
        <property type="entry name" value="Iron-sulfur cluster assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISCU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="9">
        <location>
            <begin position="36"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ46973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="185" mass="19787" checksum="0DCADDB3ADF2139C" modified="2009-07-28" version="1">MFTRTILPTTRRILTQQSRVLVPRLAIPTSTFTRSYHEKVIDHYENPRNVGSLNKESSDVGTGLVGAPACGDVMRLQIQVDEETGKIKDVKFKTFGCGSAIASSSYATELIRGKTLDEALDIKNTLIAKELSLPPVKLHCSMLAEDAIKAAVKDYQSKRKTTTLGATAASTVSSSSASAAAPATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTN9</accession>
    <name>C4YTN9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MIND complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTN9"/>
    <dbReference type="SMR" id="C4YTN9"/>
    <dbReference type="PaxDb" id="5476-C4YTN9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05534"/>
    <dbReference type="HOGENOM" id="CLU_100671_0_0_1"/>
    <dbReference type="OMA" id="QEWEDQT"/>
    <dbReference type="OrthoDB" id="2135762at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013950">
        <property type="entry name" value="Mis14/Nsl1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749:SF3">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08641">
        <property type="entry name" value="Mis14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="193"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="27094" checksum="2D2CEE88B43037E7" modified="2010-10-05" version="1">MDFQSDYEKIDLSKQDFQYVFNNILQAIMAKLNLHLPAAQNDPLKEQVSTILEEFLINTFDNSKYSILADGLDLQNVSIHDILSLKTLENVEKIDSEITIQLRKIFQEFEQETVDVTKLRRDLPKQASEMYNDIIKQTDGEVSEIINMIEQQSQEYQKVQQAHNNTDDRFEKIIESMDFSQINQNYNDHLQLLNETNKNLPSLKIEFEKYNRTVQFLEDAYQQQLKEMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTR6</accession>
    <name>C4YTR6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_05561</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTR6"/>
    <dbReference type="PaxDb" id="5476-C4YTR6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05561"/>
    <dbReference type="HOGENOM" id="CLU_020803_0_0_1"/>
    <dbReference type="OMA" id="CCDPPIE"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15535">
        <property type="entry name" value="PHD1_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15534">
        <property type="entry name" value="PHD2_PHF12_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000747">
        <property type="entry name" value="Histone deacetylase complex subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000600">
        <property type="entry name" value="Phd zn-finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052819">
        <property type="entry name" value="Chromatin_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="270"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ47007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="688" mass="77432" checksum="29B4AF8857876C5A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTT5</accession>
    <name>C4YTT5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_05580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTT5"/>
    <dbReference type="PaxDb" id="5476-C4YTT5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05580"/>
    <dbReference type="HOGENOM" id="CLU_022332_1_1_1"/>
    <dbReference type="OMA" id="WLMKSFP"/>
    <dbReference type="OrthoDB" id="18894at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="48"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ47026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="398" mass="44589" checksum="74192AD497A177C9" modified="2009-07-28" version="1">MQPVTSEESSGVSTRESFEIEDDSLQSDSNLNPLGVSLYGSKTIESIVYILGWYFFSLSISIYNKWMFGSGLDFKFPIIITSFHQLCLCILSCVVLYLKPNLRPLHTTNVSTPTSTNGISGQTIGKFLQSLLMDFPIYIRQIFPCSIASAGDIGLSNVSISLITLSLYTMLKTSSLMFVLLFGLLFKLEKFNWRLIFIVAIMTISVIMMTDKPESGSSSSSSSSSSVGIFMVLMASMLSGLRWSFTQILLKKNPYTPNSISTIFYISPGMCIILFSLGLIFEGWTNFINSEIWITKGLFTTIILLIIPGVLAFMMTLCEFKLLTVAQVITLSVAGIFKELLTIILSSIIFGDKLSLINILGLILTFMDILWYNYYRYYENEDHNNGNSKSVVREDLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCQ7</accession>
    <name>C4YCQ7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="12">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_00291</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="12">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="12"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCQ7"/>
    <dbReference type="SMR" id="C4YCQ7"/>
    <dbReference type="PaxDb" id="5476-C4YCQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00291"/>
    <dbReference type="HOGENOM" id="CLU_041802_0_1_1"/>
    <dbReference type="OMA" id="ASYMARY"/>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000001">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="14">
        <location>
            <begin position="8"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="15">
        <location>
            <begin position="120"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="16">
        <location>
            <begin position="242"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ42093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="385" mass="42260" checksum="FAA5C720D7854DDE" modified="2010-10-05" version="1">MTTSKETFLFTSESVGEGHPDKICDQVSDAILDACLAVDPLSKVACETAAKTGMIMVFGEITTKAQLDYQKIIRDTIKHIGYDDSEKGFDYKTCNVLVAIEQQSPDIAQGLHYEKALEELGAGDQGIMFGYATDETDEKLPLTILLAHKLNAALASARRSGSLPWLRPDTKTQVTIEYEKDGGAVIPKRVDTIVISTQHAEEITTENLRKEIIEHIIKQVIPEHLLDDKTIYHIQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFSKVDRSAAYAARWVAKSLVTAGLAKRALVQFSYAIGVAEPTSIYIDTYGTSKLSTEALVEIIKNNFDLRPGVIVKELDLARPIYFKTASYGHFTNQENSWEQPKKLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDI1</accession>
    <name>C4YDI1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphopyruvate hydratase</fullName>
            <ecNumber evidence="3">4.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_00576</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="3"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDI1"/>
    <dbReference type="SMR" id="C4YDI1"/>
    <dbReference type="Allergome" id="785">
        <property type="allergen name" value="Cand a Enolase"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YDI1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00576"/>
    <dbReference type="HOGENOM" id="CLU_031223_0_0_1"/>
    <dbReference type="OMA" id="RCMMSHR"/>
    <dbReference type="OrthoDB" id="1739814at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000002">
        <property type="entry name" value="Enolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00178">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="12">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="11">
        <location>
            <begin position="145"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="376"/>
            <end position="379"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ42367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="440" mass="47232" checksum="6621AFD66F275C49" modified="2009-07-28" version="1">MSYATKIHARYVYDSRGNPTVEVDFTTDKGLFRSIVPSGASTGVHEALELRDGDKSKWLGKGVLKAVANVNDIIAPALIKAKIDVVDQAKIDEFLLSLDGTPNKSKLGANAILGVSLAAANAAAAAQGIPLYKHIANISNAKKGKFVLPVPFQNVLNGGSHAGGALAFQEFMIAPTGVSTFSEALRIGSEVYHNLKSLTKKKYGQSAGNVGDEGGVAPDIKTPKEALDLIMDAIDKAGYKGKVGIAMDVASSEFYKDGKYDLDFKNPESDPSKWLSGPQLADLYEQLISEYPIVSIEDPFAEDDWDAWVHFFERVGDKIQIVGDDLTVTNPTRIKTAIEKKAANALLLKVNQIGTLTESIQAANDSYAAGWGVMVSHRSGETEDTFIADLSVGLRSGQIKTGAPARSERLAKLNQILRIEEELGSEAIYAGKDFQKASQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDJ7</accession>
    <name>C4YDJ7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_00592</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDJ7"/>
    <dbReference type="SMR" id="C4YDJ7"/>
    <dbReference type="PaxDb" id="5476-C4YDJ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00592"/>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_1"/>
    <dbReference type="OMA" id="AFPHVKP"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000002">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="9">
        <location>
            <begin position="16"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ42383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="348" mass="36807" checksum="3D6E67538522ADCF" modified="2009-07-28" version="1">MSVPTTQKAVIFETNGGKLEYKDIPVPKPKANELLINVKYSGVCHTDLHAWKGDWPLATKLPLVGGHEGAGVVVALGENVKGWKVGDYAGVKWLNGSCLNCEYCQSGAEPNCAEADLSGYTHDGSFQQYATADAVQAARIPAGTDLANVAPILCAGVTVYKALKTAELEAGQWVAISGAAGGLGSLAVQYAKAMGYRVLAIDGGEDKGEFVKSLGAETFIDFTKEKDVVEAVKKATNGGPHGVINVSVSERAIGQSTEYVRTLGKVVLVGLPAGAKISTPVFDAVIKTIQIKGSYVGNRKDTAEAVDFFTRGLIKCPIKIVGLSELPEVYKLMEEGKILGRYVLDNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDK4</accession>
    <name>C4YDK4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4</fullName>
            <ecNumber evidence="6">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Carbon catabolite repressor protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Cytoplasmic deadenylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Glucose-repressible alcohol dehydrogenase transcriptional effector</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">CAWG_00601</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="6"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDK4"/>
    <dbReference type="PaxDb" id="5476-C4YDK4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00601"/>
    <dbReference type="HOGENOM" id="CLU_016428_4_1_1"/>
    <dbReference type="OMA" id="EHRMVAP"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09097">
        <property type="entry name" value="Deadenylase_CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000037">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000598">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="24">
        <location>
            <begin position="457"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="90"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00033317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EEQ42390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="785" mass="90181" checksum="2327876A2EA9C8A8" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDK5</accession>
    <name>C4YDK5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Multiple drug resistance-associated protein-like transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_00602</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily.</text>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
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                <person name="Forche A."/>
                <person name="Reedy J.L."/>
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                <person name="Brunke S."/>
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    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="403" mass="45853" checksum="507FE66DB92E53A0" modified="2009-07-28" version="1">MSSSADEIEYLATEIITNSKPVSYHKFSRQLNIHVSKAKATLLEYYQKNKNDLTATFIVTGSNDNGKLIKLSNEDDLESDLKKFTTVHCVHVYSIHKKSIQFSNNELALEELKHPSSLNKISEYEKNGIIIGPKIEKAIPLNIPSSPVKPEPSHKNKPTEEKKSSSSLLSSYVSRKQEKKQQDTRSGTLSNYVSRKTEPTIPSKRSNTEPATKPTYQYKSRKLEAKAPKERVIIAENNDNEDEEDDDDDKPIKASRATNTSDLQRMFDGDDFTFSDDDESPEKEIKETEEPKDEDKKDILPESPKEEQQSKEASPENKPGLFVNEEEEEEEEKEQEETRSGEQEEFITEKDEEGYLITRKVKPITKQAKPKKQVVPPKVTKPSTGKKTGMKQSSLMSFFGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEE1</accession>
    <name>C4YEE1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_00898</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEE1"/>
    <dbReference type="PaxDb" id="5476-C4YEE1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00898"/>
    <dbReference type="HOGENOM" id="CLU_062255_0_0_1"/>
    <dbReference type="OMA" id="DMAVCEN"/>
    <dbReference type="OrthoDB" id="423462at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="65"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ42677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="377" mass="43112" checksum="97FFB17E2D6D13A0" modified="2009-07-28" version="1">MSTTEQSSQSKPAVLCSFYTKIGSCRHGEECSKKHLKPTITKTILLPNLYQNPRFDLVEYLSRNRKQHRVKKRKTGDKNSDDIAEINFETKDGVKDNEEKANVDGENKEHDETKEIESKDVISKDKEEIIVDESGIAQQDKQKESNKEGKQEGESEKEEPNKESTEEELPPQGVTQEVPNHYQEESPIKQEQTAAKQEKHGLDENHPVLTDEQIQKDFDLFYQDIFVHVAKLGQINDMAVCENENHLSGHVYIKFNDYNDAIAANLQLNQEWYNGKPVYSELSPVNILADAHCKSWDHGHCDRGAKCNYLHVKQPTQGIKKSLWDSQTKTYTLKKLEMLKKEVPEEIMSGASSDNGNKVNTKDIEIRSTMALLESMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF01</accession>
    <name>C4YF01_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_01110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF01"/>
    <dbReference type="PaxDb" id="5476-C4YF01"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01110"/>
    <dbReference type="HOGENOM" id="CLU_986944_0_0_1"/>
    <dbReference type="OMA" id="PILETKF"/>
    <dbReference type="OrthoDB" id="10460458at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ42887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="295" mass="32930" checksum="EF425B78269F865E" modified="2010-10-05" version="1">MIQQSSNMATTAVFEETNTDFDTSLMEFFYSTTSEDALPDVNDTSSTTITEVANEIPSLFSYSNNDLHPELDYESSSWYDITESLPQNIPDSKSEPIATNPTNVLTSPLQAFADFNHGSSTGLTTKQPELFHHNNNAINGSFKNNDYTTNKINTNTTTTTTKQRISKPYERSPLMKPSVTIASIDTIAKLKTKSKSNCKSSSISKPKVRNPFYKPFISSSISSETALKNTKIINFRDENNDNSSSFNFTDIDNKLTYDLSTETTNSSFPQTVLEASFKNFDDALIFDSLFDINQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF10</accession>
    <name>C4YF10_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="9">3.2.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_01120</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="9"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF10"/>
    <dbReference type="PaxDb" id="5476-C4YF10"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01120"/>
    <dbReference type="HOGENOM" id="CLU_004624_0_1_1"/>
    <dbReference type="OMA" id="GWDMQDL"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000140">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF1">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE I_II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944669" description="glucan 1,3-beta-glucosidase" evidence="11">
        <location>
            <begin position="22"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="12">
        <location>
            <begin position="95"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ42896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="479" mass="54593" checksum="9F9BE6601DCCB006" modified="2009-07-28" version="1">MMLFLIHLMALCCMFVAEVACEQFNSTSNSSSVQSSLIDFQYKGVSIGGWLVLEPYITPSLFNATLSSGETWTDLPVDEYHFCEKLGAKEAEKRLTDHWESMYNETDFKQIKEAGLNMVRIPIGYWSFEKLEGDPYVSGAQDYLDKAIEWSHANDLKVMIDLHGAPNTQNGFDNSGLRNLGYPGWQNKTEYVNHTYKVLQQMFQKYGTGKYASDYKNTIIGIEVLNEPLNPNMDKLKEFYIESYNDGREIQVINNTIFFQEAFQPIGYWDSFLEKGEIKVTETSNGTNHTTTKKADFKNIIIDHHHYEVFTESQVASNVSTHLENIKNYASAIGKEKAKAIVGEWSAALTDCAPWLNGIGLGSRYEGTAPYTNDRVGSCAEFNKSPDKWSKKQKKDYRRFVEMQLYEYSTNSQGWIFWCWKTEGATEWDFRALVKNGIMPQPLDNYKYVKNGTDTSSASAIASNKMTLLLAYLLVILVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF35</accession>
    <name>C4YF35_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf family GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_01146</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF35"/>
    <dbReference type="PaxDb" id="5476-C4YF35"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01146"/>
    <dbReference type="HOGENOM" id="CLU_040729_12_3_1"/>
    <dbReference type="OMA" id="KTHHWQI"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="145"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ42921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="23502" checksum="1F86CB0D3F9E8D89" modified="2009-07-28" version="1">MGLLTIIKKQKLKDNEIRVLTLGLDNSGKTTIIKKMLNQDINTISPTMGFQINTLFYTPKNNHHQHNNNNSNSNDNDEYTLNIWDIGGQISLRSFWANYFDKTDIVIWVIDGLSLERLNESYKELKQKIILQDRLIGIYLIVVINKIDIIPQRDWSNLKTKVIDLLQLNKQIPQRDKWQVELVSGKTGEGIDKVLQWIVTRE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-31" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFD4</accession>
    <name>AIM9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">AIM9</name>
        <name type="synonym">FMP29</name>
        <name type="ORF">CAWG_01251</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIM9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFD4"/>
    <dbReference type="PaxDb" id="5476-C4YFD4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01251"/>
    <dbReference type="HOGENOM" id="CLU_019189_0_1_1"/>
    <dbReference type="OMA" id="GWIPQDM"/>
    <dbReference type="OrthoDB" id="2968323at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000408717" description="Altered inheritance of mitochondria protein 9, mitochondrial">
        <location>
            <begin position="35"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="624" mass="71369" checksum="2634D9B6E4938768" modified="2009-07-28" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFF8</accession>
    <name>C4YFF8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HNRNP arginine N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_01271</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFF8"/>
    <dbReference type="SMR" id="C4YFF8"/>
    <dbReference type="PaxDb" id="5476-C4YFF8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01271"/>
    <dbReference type="HOGENOM" id="CLU_017375_1_2_1"/>
    <dbReference type="OMA" id="CTHTKVK"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000050">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="5">
        <location>
            <begin position="159"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ43039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="339" mass="39313" checksum="82E5BBABB53CBE2A" modified="2010-10-05" version="1">MSESATDKSQLSKFEQHYFSSYDHFGIHEEMLKDTSRTLSYRNAMYRNKDLFKDKIVLDVGCGTGILSMFAVKAGAKHVYSVDMSSIIDKAKEIVELNGFSDKITLLQGKLEDINLPVDKVDIIISEWMGYFLLYESMLDTVLYARDRYLVEGGLIFPDKCQMYIAGIEDAQYKDEKIHYWEDVYGFDYTPFIKTAMEEPLVDTVNNQSLITKGTQFFEFDINTVTKEQLSIKRKFELQAIDNDYCHAFIVYWDAVFPGKQRVILPTGPMHQYTHWKQTVFYMDQVLDLKKGDTINGEITAVPSKINPRELDIDISWEVKTQANDKSRELKGGYTYFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFT1</accession>
    <name>C4YFT1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CAP1-binding-protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_00057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFT1"/>
    <dbReference type="PaxDb" id="5476-C4YFT1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00057"/>
    <dbReference type="HOGENOM" id="CLU_024514_0_0_1"/>
    <dbReference type="OMA" id="TYEIGWD"/>
    <dbReference type="OrthoDB" id="5396786at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013877">
        <property type="entry name" value="YAP-bd/ALF4/Glomulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040347">
        <property type="entry name" value="YBP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28020">
        <property type="entry name" value="YAP1-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28020:SF1">
        <property type="entry name" value="YAP1-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08568">
        <property type="entry name" value="Kinetochor_Ybp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ41870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="643" mass="73998" checksum="8D5E8353C0C1C80B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFV8</accession>
    <name>C4YFV8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_00084</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="5">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFV8"/>
    <dbReference type="PaxDb" id="5476-C4YFV8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00084"/>
    <dbReference type="HOGENOM" id="CLU_097408_2_0_1"/>
    <dbReference type="OMA" id="KEHEWIR"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="70"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="4">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ41897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="181" mass="20479" checksum="780602532233CA86" modified="2009-07-28" version="1">MIRTLLRPTSLRPTSLRLVTPTFRSFSTFSTRFQLIDKDSHAYKYLYEKTPVVTKFTEDHEWVHLYDDDSAFVGITQYAAQALGDVTFVDLPEVGDHLELNETLGSVESVKSSADVYSPVDGEVVGVNLKLESEPGILNHDPTKGGWIVHIKLDDPTQVTKSETLMSEEQYKKFLEEEEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFX4</accession>
    <name>C4YFX4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_150405_0_0_1"/>
    <dbReference type="OMA" id="CTTFNSC"/>
    <dbReference type="OrthoDB" id="4092858at2759"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021017">
        <property type="entry name" value="Mediator_Med2_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11214">
        <property type="entry name" value="Med2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="174" mass="20425" checksum="54A08A44C99C2A81" modified="2009-07-28" version="1">MPENLQTRLHNSLDEILKSSGYIFEVIDQNRKQSNVITSPNNELIQKSITQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKLDELKVKEEAARKKEEEAKKAEQAKKAEEAKKCFILLFCQICTTFNLCANILFYLIFIYFYFTILFYRTFYIFSLSTHLLYNIFLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGA3</accession>
    <name>C4YGA3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGA3"/>
    <dbReference type="PaxDb" id="5476-C4YGA3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00224"/>
    <dbReference type="HOGENOM" id="CLU_711705_0_0_1"/>
    <dbReference type="OMA" id="YIFDEEY"/>
    <dbReference type="OrthoDB" id="10328700at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="388" mass="44600" checksum="EE301C4CC4866473" modified="2009-07-28" version="1">MSIHPGTKEEINGVTKELSKVGIMQGSKQESKPVLENHQQQSFTPNTSLQSAETNSPDTPNTSISSADTILGTSTQELVKSIPPPRVENNRRLIAIPKPHYNVVKPTEYTPLAEYYAAQSPHHPKLREVRRLESAKAPIDLYRIANRNNNINVPATKLTADISAMFKHSTNTEVRKVISNVLVSTEKSLKKKLADLPTYFKKLVHAFEKNPEVYLRVNAEPIFGENYTVYEYFDDRDLSHLYYRCRYFHIDDDHRIYFQAFNPDTIGKPEYAHLRQLLVSSLEKLVFEIGGEKFSIKIDEPVEHMHVVAFKLPPTSLVDTVEYLEYFLDEKDEIVESRIPVFSPKSMIQDSTPVTAFFILKLRGKQLPPERKYIFDEEYSFNILTNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGT7</accession>
    <name>C4YGT7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGT7"/>
    <dbReference type="PaxDb" id="5476-C4YGT7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03269"/>
    <dbReference type="HOGENOM" id="CLU_624948_0_0_1"/>
    <dbReference type="OrthoDB" id="4022940at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="512" mass="56606" checksum="B5A37D28D7DA79F7" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGV8</accession>
    <name>C4YGV8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="19 20">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 20">2.7.8.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CAWG_03294</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 20">
            <text>a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20 21">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.11" evidence="5 20"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGV8"/>
    <dbReference type="PaxDb" id="5476-C4YGV8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03294"/>
    <dbReference type="HOGENOM" id="CLU_067602_0_0_1"/>
    <dbReference type="OMA" id="VTGVFFY"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000021">
        <property type="entry name" value="CDP-diacylglycerol--inositol 3-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014387">
        <property type="entry name" value="CDP_diag_ino_3_P_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000848">
        <property type="entry name" value="CDP_diag_ino_3_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 20 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 20" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="17 20" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00050166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00070582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRNR" id="PIRNR000848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EEQ44990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="230" mass="26246" checksum="6667051102AA0540" modified="2009-07-28" version="1">MPSAKSSDLSPTKTNFESTTKQKVSVQDIFLYIPNLIGYLRIITAIISFLCMANHPVATLIFYGISGFLDAFDGYAARKFNQGTRFGAVLDMVTDRCATSSLIVYLGVLYPQYTVFWQILVSLDLSSHYMHMYAMLSAGSTSHKNVDETQSKLLSLYYNNRLVLFFVCLINELFYMAVYLHYYKFFWLGTVMLVASTPIWLFKQIANIIQLKNASLILARMDAHDHSKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH23</accession>
    <name>C4YH23_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_03364</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YH23"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03364"/>
    <dbReference type="HOGENOM" id="CLU_272804_0_0_1"/>
    <dbReference type="OMA" id="QFNNHYK"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001578">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000206">
        <property type="entry name" value="Serine/threonine-protein kinase Ssp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF152">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="275"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="87"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="762"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="833"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="897"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1099"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1131"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1383"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="834"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="897"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="916"/>
            <end position="929"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1102"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1131"/>
            <end position="1143"/>
        </location>
    </feature>
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        <location>
            <begin position="1144"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ45055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1408" mass="155961" checksum="4A411EE75F61F5BA" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH53</accession>
    <name>C4YH53_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall protein RHD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4018368at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013379595" description="Cell wall protein RHD3" evidence="1">
        <location>
            <begin position="16"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="21474" checksum="00A2BFD68F7F34EA" modified="2010-10-05" version="1">MKFLAILSLSSSALATISSIQLFAKSDDSKVDGLGLYSKHEGAAIDYLFLGKNGADLKYDDEKKQIFQELKTSSITVRQSFTLGGDVYELGATDNFIPVTINKDGTLSFTGDDKVYASKNVNDPYRYSESEYAVSNKKTDDSAPITIVAKFSDDKAAETSGVAQAASSSAGPAQASVSNFEGAAGQNKLSYGVGMAAVVAGLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHF5</accession>
    <name>C4YHF5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="11">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_03501</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 11">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="11"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YHF5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03501"/>
    <dbReference type="HOGENOM" id="CLU_238060_0_0_1"/>
    <dbReference type="OMA" id="WANTISM"/>
    <dbReference type="OrthoDB" id="26387at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19672">
        <property type="entry name" value="UBR-box_UBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000002">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase ubr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF26">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="13">
        <location>
            <begin position="88"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="1200"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="10">
        <location>
            <begin position="88"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ45187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1787" mass="203020" checksum="58C68A841FC05E40" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHK9</accession>
    <name>C4YHK9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_03556</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHK9"/>
    <dbReference type="PaxDb" id="5476-C4YHK9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03556"/>
    <dbReference type="HOGENOM" id="CLU_105987_0_0_1"/>
    <dbReference type="OMA" id="DNACHTE"/>
    <dbReference type="OrthoDB" id="10591344at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025928">
        <property type="entry name" value="Flocculin_t3_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13928">
        <property type="entry name" value="Flocculin_t3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944715" evidence="7">
        <location>
            <begin position="19"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="120"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ45241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="213" mass="21255" checksum="6EB880A0EA0AB03E" modified="2010-10-05" version="1">MQFSSAVVLSAVAGSALAAYSNSTVTDIQTTVVTITSCEENKCHETEVTTGVTTVTEVDTTYTTYCPLSTTEAPAPSTATDVSTTVVTITSCEEDKCHETAVTTGVTTVTEGTTIYTTYCPLPSTEAPGPAPSTAEESKPAESSPVPTTAAESSPAKTTAAESSPAQETTPKTVAAESSSAETTAPAVSTAEAGAAANAVPVAAGLLALAALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHM2</accession>
    <name>C4YHM2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Protein ROT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_03570</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for normal levels of the cell wall 1,6-beta-glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ROT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHM2"/>
    <dbReference type="PaxDb" id="5476-C4YHM2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03570"/>
    <dbReference type="HOGENOM" id="CLU_071622_0_1_1"/>
    <dbReference type="OMA" id="IWQHGKY"/>
    <dbReference type="OrthoDB" id="5327821at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007118">
        <property type="term" value="P:budding cell apical bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019623">
        <property type="entry name" value="Rot1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090:SF1">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10681">
        <property type="entry name" value="Rot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017290">
        <property type="entry name" value="ROT1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944230" description="Protein ROT1" evidence="10">
        <location>
            <begin position="22"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ45254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="193" mass="22299" checksum="39894C5C5ED95716" modified="2010-10-05" version="1">MLMYTILIPSLLYIALTIASSELLNSIQGTWQSQSERVITGPTFFDPQKELLEEPKLPGISYSFKNGYWESAQYIVMGNNRNHQCPQAMLIWQHGKYNLKRGKLVLIPNRNDGRQLISDPCLDNGKSEYKRFHNGETLEVDIRFDGYFGNWKLVLVDYLTGKKKQPMWLTSRNATMLPTGTITSTKRKYVKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHM6</accession>
    <name>C4YHM6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_03574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHM6"/>
    <dbReference type="PaxDb" id="5476-C4YHM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03574"/>
    <dbReference type="HOGENOM" id="CLU_107714_2_0_1"/>
    <dbReference type="OMA" id="KMRFYQV"/>
    <dbReference type="OrthoDB" id="3468019at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39401">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39401:SF1">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ45258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16726" checksum="82885D40E87F1EDB" modified="2009-07-28" version="1">MTNYSPGIQNNEKLKEFIVKFYKASDKAPRSDEQHDPYLDFFTTNSPLVMGLKKVEGHQEIAQLRQGMWEKVTHRHHVVNNVAEINEKEILLNGYVEYTLINGKNVTTEWAGHMKLENSTGGENGYKMNYYQVYLDPSAAAKALSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHM8</accession>
    <name>C4YHM8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_03576</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHM8"/>
    <dbReference type="PaxDb" id="5476-C4YHM8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03576"/>
    <dbReference type="HOGENOM" id="CLU_007695_0_0_1"/>
    <dbReference type="OMA" id="RNPFVLY"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF6">
        <property type="entry name" value="PROLINE UTILIZATION TRANS-ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="673"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="749"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="682"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="763"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ45260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="830" mass="95521" checksum="F3AD5B11C94F96F6" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHW0</accession>
    <name>C4YHW0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_03663</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHW0"/>
    <dbReference type="SMR" id="C4YHW0"/>
    <dbReference type="PaxDb" id="5476-C4YHW0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03663"/>
    <dbReference type="HOGENOM" id="CLU_032440_1_0_1"/>
    <dbReference type="OMA" id="YSIYLCE"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="32"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ45342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="409" mass="46834" checksum="B6EED5D95876070E" modified="2009-07-28" version="1">MTVKSKFTHLTKEEPDPIIKTLTQYHQDQSPNKLDVSIGVYKSPDGLLYTFPSIIEAKEIYHNEKNYGHNYTTMSGIKEFINGSQQLLFGKDVITSDGEKKIASIQTIAGTGAIHMGLLFFMEAGYKNFYLGLPSWSNYIPMIETVGGKVNTYEYYNTANGEINFDTVKKTLIEAPKNSVFIFQTCCHNPTGADFNNDQWIEVVKLIKQYDHLVLMDTAYLGFSSGDLIKDSWILRYMYEEAEIEFVVAQSFSKNMGLYGERLGAVHVIVQDENYVDHAQSTLVANFRHECSFAPSFGARLAQIIFENDKLYQQWTKEVNQVTQRLQNLRQLVYQTLIKLETPGNWKTVIQQKGLFWYSGLTPQQNDRLISNHNVYSTSIGRVNIAGLNEQNVEYFCKAIDEVVRHNYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHZ2</accession>
    <name>C4YHZ2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="3">1.3.1.124</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_03698</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="3"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHZ2"/>
    <dbReference type="SMR" id="C4YHZ2"/>
    <dbReference type="PaxDb" id="5476-C4YHZ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03698"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_1"/>
    <dbReference type="OMA" id="QLRDWSD"/>
    <dbReference type="OrthoDB" id="2136131at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ45374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="290" mass="30874" checksum="0F3CABD0EA575B45" modified="2010-10-05" version="1">MPNTLDKSYLEKSVWKSDIFKGKVAFITGGAGTICRVQAEALVLLGADVAIIGRNPQKTEDAAKEIATLRPGAKVIGIGNVDVRKIQTIKEAADRTVKELGRIDHVIAGAAGNFLSDFNHLSSNAFKSVIDIDLLGSFNTVKVCFEELRKNKGSVIFVSATLHYYGLPMQLHASAAKAGVDALSNALAVELGPLGIRFNCIAPGAIGGTEGMSRLSPPNETPLEQKIPLQRQGTTTDIADATIYLFSPAASYVTGDVLVVDGAWWQVGGFLGDLYPSLVIHQNEDPQGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIV9</accession>
    <name>C4YIV9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA (guanine(9)-N1)-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">tRNA methyltransferase 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA(m1G9)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAWG_04388</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="4"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ46044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIV9"/>
    <dbReference type="PaxDb" id="5476-C4YIV9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04388"/>
    <dbReference type="HOGENOM" id="CLU_034384_1_0_1"/>
    <dbReference type="OMA" id="FKKNDGW"/>
    <dbReference type="OrthoDB" id="278300at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18089">
        <property type="entry name" value="SPOUT_Trm10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.30:FF:000004">
        <property type="entry name" value="tRNA (guanine(9)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016653">
        <property type="entry name" value="TRM10/TRM10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016323">
        <property type="entry name" value="tRNA_m1G_mtfrase_met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 19" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="18">
        <location>
            <begin position="99"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR016323-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEQ46044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="327" mass="38321" checksum="35A4763DE9B74FD0" modified="2009-07-28" version="1">MTEQTSEATVVNNPPTPTIPKIKREKPTPEEIEERRKLKQLEVIPEGFSRKQWKRELKKQRWQDTKQEYLEVQREKKRLARQRKRERLKDLDENDELRKAQRIPSRQKSTNNVSVIIDCDFDELMHEKEIVSLSNQIKACYSAMRHCTYKLPIQITSFNKRLKQRFEAQLHDYHLWQGNISFTDRSLTEYVTGAPDSESKDNDGNSNSNSNSNTTNSTDMINTENLVYLTADTDEEITKLEPNHTYIIGGIVDKNRHKQLCYNKAKELGIKVARLPIGKYIEMNGRHVLVTSHVYELLCKWFENDGDWETAFNKVLPPRKIKSKSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ15</accession>
    <name>C4YJ15_CANAW</name>
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        <recommendedName>
            <fullName evidence="9">Pom152p</fullName>
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    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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    </feature>
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        <location>
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    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ45499.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1261" mass="144338" checksum="E169200695061824" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ54</accession>
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        </submittedName>
    </protein>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
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                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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                <person name="Cuomo C.A."/>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
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        <property type="term" value="C:late endosome membrane"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:endosomal transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ45538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="152" mass="17239" checksum="96614EDD19FC7C55" modified="2010-10-05" version="1">MGNCLSCLIGNSNDDDYNETSSLLRHQQQHNQQYLSDYLQEEQILKQQQRQQELAGIVNELNDNLIDVTSFLSGNNNNNNNNNASLGNSGILANESNINEEEHTQVGNTIKSLPYLYTKEDKDEILKKLSDIDADVKQSFKIQSSVPLYIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJB7</accession>
    <name>C4YJB7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligoribonuclease, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_03930</name>
    </gene>
    <organism evidence="7 8">
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        <name type="common">Yeast</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJB7"/>
    <dbReference type="PaxDb" id="5476-C4YJB7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03930"/>
    <dbReference type="HOGENOM" id="CLU_064761_0_0_1"/>
    <dbReference type="OMA" id="AFFHYRN"/>
    <dbReference type="OrthoDB" id="270189at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000003">
        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003765">
        <property type="entry name" value="PRK05359.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF0">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="6">
        <location>
            <begin position="28"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="208"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ45601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="237" mass="27747" checksum="0B55D05564067EBC" modified="2009-07-28" version="1">MQDPPIKKTKLDLMQSFLKEKPQIPKKPLVWVDCEMTGLDVFGDDNIIEICCIITNEDLDIVDENGYESTIYYPKSRLDKMNEWCIETHGKSGLTDKILANPDRKLSVVEDELLEYIKKYVPEVRTGLLAGNSVHMDRFFMMKEFPKVIDHLHYRNVDVSSIMEFGYRHNPKLMKMFPKKTGAHTAKSDILESIEQLKWYRKYYFKSEEETKETIESLSSELPEEETKDTSTETNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJC3</accession>
    <name>C4YJC3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin cytoskeleton-regulatory complex protein SLA1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Actin cytoskeleton-regulatory complex protein sla1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CAWG_03936</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">WO-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="18">Component of the PAN1 actin cytoskeleton-regulatory complex. Interacts with ABP1, KRE6, LAS17, LSB5, RSP5, RVS167, VPS1 and YSC84.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SLA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJC3"/>
    <dbReference type="PaxDb" id="5476-C4YJC3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03936"/>
    <dbReference type="HOGENOM" id="CLU_003674_0_0_1"/>
    <dbReference type="OMA" id="FMAQGED"/>
    <dbReference type="OrthoDB" id="26539at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071554">
        <property type="term" value="P:cell wall organization or biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09532">
        <property type="entry name" value="SAM_SLA1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11773">
        <property type="entry name" value="SH3_Sla1p_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11774">
        <property type="entry name" value="SH3_Sla1p_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11775">
        <property type="entry name" value="SH3_Sla1p_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000094">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000256">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000300">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000328">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein sla1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.700:FF:000001">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.700">
        <property type="entry name" value="SLA1 homology domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013182">
        <property type="entry name" value="DUF1720"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056996">
        <property type="entry name" value="PH_SLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007131">
        <property type="entry name" value="SHD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035800">
        <property type="entry name" value="Sla1_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035821">
        <property type="entry name" value="Sla1_SH3_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF19">
        <property type="entry name" value="ACTIN CYTOSKELETON-REGULATORY COMPLEX PROTEIN SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08226">
        <property type="entry name" value="DUF1720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24081">
        <property type="entry name" value="PH_SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03983">
        <property type="entry name" value="SHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="13" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 20" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="SH3" evidence="22">
        <location>
            <begin position="4"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="22">
        <location>
            <begin position="75"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="22">
        <location>
            <begin position="396"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="133"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="464"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="596"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="718"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="789"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1057"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1207"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="189"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="605"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="846"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1057"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1082"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1117"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1136"/>
            <end position="1168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00064470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00070651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EEQ45607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1257" mass="138842" checksum="5867302E47716522" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJH2</accession>
    <name>C4YJH2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cobalt uptake protein COT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_03987</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJH2"/>
    <dbReference type="PaxDb" id="5476-C4YJH2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03987"/>
    <dbReference type="HOGENOM" id="CLU_013430_9_5_1"/>
    <dbReference type="OMA" id="KWIRNII"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000026">
        <property type="entry name" value="Zinc/cadmium resistance protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="9"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="137"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ45656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="199" mass="21784" checksum="97E93E5A89D31ECD" modified="2009-07-28" version="1">MNSKEIRIVALLILDTVFFLLEAIIGYTVHSLALIADSFHMLNDIISLIIALWAVRVKNTKPADGKYTYGWQRAEILGALINAVFLLALCFTIIMDSIQRFFEPQEISNPKLILIVGIAGLVSNGVGLVLFHEHGHSHSHGSGGGGGGSDHSGDSKSHSHSHSHSHGEATTFSQGDEEDILAPKKMNIHHYYIILLIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJY5</accession>
    <name>C4YJY5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_05777</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJY5"/>
    <dbReference type="PaxDb" id="5476-C4YJY5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05777"/>
    <dbReference type="HOGENOM" id="CLU_039091_0_0_1"/>
    <dbReference type="OMA" id="IPSQYII"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052788">
        <property type="entry name" value="RING-type_E3_ligase_ATL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45798:SF97">
        <property type="entry name" value="ALCOHOL-SENSITIVE RING FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45798">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL61-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="15"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="305"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="384"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ47214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="546" mass="62122" checksum="19AA35C169FDB19D" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK10</accession>
    <name>C4YK10_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_05803</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK10"/>
    <dbReference type="PaxDb" id="5476-C4YK10"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05803"/>
    <dbReference type="HOGENOM" id="CLU_012062_21_2_1"/>
    <dbReference type="OMA" id="IVWELMI"/>
    <dbReference type="OrthoDB" id="10259687at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12334">
        <property type="entry name" value="RRM1_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001696">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001468">
        <property type="entry name" value="U2 snRNP complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034158">
        <property type="entry name" value="SF3B4_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052084">
        <property type="entry name" value="SF3B4_spliceosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030:SF3">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="17"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="127"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="208"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ47239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="259" mass="29393" checksum="38F095E749EBA4CD" modified="2009-07-28" version="1">MSIIFRKRLDSDRNIDASLYFGNIDPQVTELLMYELFIQFGPVKSINMPKDRILKTHQGYGFVEFKNSADAKYTMEILRGIRLYGKALKLKRIDAKSQSSTNNPNNQTIGTFVQSDLINPNYIDVGAKLFINNLNPLVDESFLMDTFSKFGTLIRNPIIRRDSEGHSLGYGFLTYDDFESSDLCIQKMNNTILMNNKITISYAFKDSSVDGKKSRHGDQVERTLAESAKKNNLLVTKTSKAGTTKGNKRKNKPHKVTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK41</accession>
    <name>C4YK41_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aspartate protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_05836</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK41"/>
    <dbReference type="MEROPS" id="A01.018"/>
    <dbReference type="PaxDb" id="5476-C4YK41"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05836"/>
    <dbReference type="HOGENOM" id="CLU_013253_3_4_1"/>
    <dbReference type="OMA" id="KYDHDAS"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05488">
        <property type="entry name" value="Proteinase_A_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000036">
        <property type="entry name" value="Vacuolar aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000002">
        <property type="entry name" value="Vacuolar aspartic proteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033819">
        <property type="entry name" value="Saccharopepsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944272" description="Aspartate protease" evidence="14">
        <location>
            <begin position="23"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="15">
        <location>
            <begin position="104"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="135"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="341"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEQ47270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="419" mass="45479" checksum="5E6664393B71733F" modified="2009-07-28" version="1">MQLSLSALTTVALALTSSLVDAKAHSIKLSKLSNEETLDASNFQEYTNSLANKYLNLFNTAHGNPSNFGLQHVLTNQEAEIPFVTPKKGGKYDAPLTNYLNAQYFTEIQIGTPGQPFKVILDTGSSNLWVPSQDCTSLACFLHAKYDHDASSTYKVNGSEFSIQYGSGSMEGYISQDVLTIGDLVIPGQDFAEATSEPGLAFAFGKFDGILGLAYDTISVNHIVPPIYNAINQGLLEKPQFGFYLGSTDKDENDDGLATFGGYDASLFQGKITWLPIRRKAYWEVSFEGIGLGDEYAELHKTGAAIDTGTSLITLPSSLAEIINAKIGATKSWSGQYQVDCAKRDSLPDLTLTFAGYNFTLTPYDYILEVSGSCISVFTPMDFPQPIGDLAIVGDAFLRKYYSIYDLDKNAVGLAPSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK92</accession>
    <name>C4YK92_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Nucleoporin SEH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_05889</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK92"/>
    <dbReference type="PaxDb" id="5476-C4YK92"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05889"/>
    <dbReference type="HOGENOM" id="CLU_032441_1_1_1"/>
    <dbReference type="OMA" id="NAPTRRW"/>
    <dbReference type="OrthoDB" id="5566198at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000578">
        <property type="entry name" value="Nucleoporin seh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="61"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="285"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ47321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="38887" checksum="129DF97C9A0EF99D" modified="2009-07-28" version="1">MSIDSLIYPAMKPFITGHEELIHDIKYDFYGKHIATVSSDQHIKVFDLDSAISSWILNDSWKAHDSSIAKISWAHPEFSSSKIIASCSYDRTVKIWQEQPDEMPGSGRRWLKLATLATESYGPIYDVCFAPNHLGFKLGCVGSDGIFRIYESLGPNDLTAWVLTTEIAILNSSLPAKSLQSSFGVEWCPSKFTKTEKFIVVALDQGFVYGSVQKESSGEESASDKYVKICDLPEHNGLIRSVSWAPSMGRKYHLIATGCKDGFVRIFKATEQENGDLKIETLAKLNDHKSEVWRVSWNMTGTILSSAGDDGKLRLWKCSYLNEWKCMSVINTSNRSDSRGIETEKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKE2</accession>
    <name>C4YKE2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_05944</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the GSE complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKE2"/>
    <dbReference type="PaxDb" id="5476-C4YKE2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05944"/>
    <dbReference type="HOGENOM" id="CLU_044099_1_0_1"/>
    <dbReference type="OMA" id="LIPNMQD"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.190:FF:000006">
        <property type="entry name" value="GTR1p Cytoplasmic GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ47371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="281" mass="33105" checksum="A85F9FB4AC5D2F51" modified="2009-07-28" version="1">MTLNLWDCGGQTVFMDNYFTNQKDHIFKMVQVLIHVFDVESKSINKDIEIFIKSLTNLQQYSPGAKVFVLLHKMDLVQIDKRQELFEIMMEKLQKISNPYHFKLIGFPTSIWDESLYKAWSQIVCSLIPNINLFNNNLIEFNSILDAEEIILFEKTTFLVISSTASIQSQQQRQQQQKSIDNDQDSTNEELDPKRFEKISNIIKTYKQSITKLRTNFKNLIIRGSNGTNFYIDIITDNMFIMIVLKDKKDTQNMIQQHEELLILDNIKAARKWFEKIENNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL18</accession>
    <name>C4YL18_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_01532</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL18"/>
    <dbReference type="PaxDb" id="5476-C4YL18"/>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="OMA" id="IASCMNE"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="32"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ43299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="299" mass="34035" checksum="317FF83712A2AA5D" modified="2009-07-28" version="1">MLEMMKRENVLYPVENDNFTYVVVEEAEAKGAFDKPLKDHPHIKVFIDTASPLPIGVNYEKQLIRRTSKGIKYILSSIKDHGPNITKVVVTSSIASCMNEKQSHDPNFVVDESKWNPDKHSVGKNNPTSAYFYAKASAEHEAWDFMKKKTHFTLATILPGYTFGPQCFDEDVSDLLETSVEIVTKIFELNKNDPIPKESGLFVDVRDVAAAHIRAFELNEAQNKRLMLVSEPFSAQEIVDILHEMYPAVQLPLGHPGDKPNYKFNNIETKKILNTDFRSLRSSIKDDYDQYLRTHGIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL35</accession>
    <name>C4YL35_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_01550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL35"/>
    <dbReference type="PaxDb" id="5476-C4YL35"/>
    <dbReference type="HOGENOM" id="CLU_005316_7_4_1"/>
    <dbReference type="OMA" id="SFKSRIY"/>
    <dbReference type="OrthoDB" id="435282at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000496">
        <property type="entry name" value="Chromosome 21, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048889">
        <property type="entry name" value="NSUN5_RCM1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF4">
        <property type="entry name" value="28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21153">
        <property type="entry name" value="NSUN5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="162"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="269"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="492" mass="56202" checksum="5D4E1BA90DFD64FB" modified="2009-07-28" version="1">MKKKNTYKKKYQIIFIGPISSHFLYITYTPMKLYFEAEKFLKPNKGTNGSLQSRIFNDKRLTNSPKHIFALVYSTLKYKEYIDVIVKKSKIQHDLQIKKVKMSNELLCLLVHDLLFSSKGRIQSGKHPMKDAFLSNKTRLQAEFTKLKLKYKVKSVDQLPTKEADDDETPIRWFRINTIKIDIDRFYTKHPFFKQLQPVSSIDEITETGIIYSDDYIPNLFGVHPREKITSTEAYRLGEIIIQDRASCFPSHILNADPEDVHTQVIDACAAPGNKTTHAAAHLPNSDSVVYAFERDSKRVKILKTMCEKATGKTKKKLIQVTHADFTTTKPEDFPDVTGLVVDPSCSGSGIFGRALEDSHNEEEIENVNTERLNKLAGFQFAIMKHALSFPSARKVVYSTCSIHAQENERVVVDLLSDPEVNRRGWKLADREIVLPKWDRRGFEEEFIKISRDPKECARLAGGCVRANPKEDGGIGFFAACFVRSTEVNHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLC9</accession>
    <name>C4YLC9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutamate--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_01647</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLC9"/>
    <dbReference type="PaxDb" id="5476-C4YLC9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01647"/>
    <dbReference type="HOGENOM" id="CLU_015768_6_3_1"/>
    <dbReference type="OMA" id="HGATNVM"/>
    <dbReference type="OrthoDB" id="428822at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000045">
        <property type="entry name" value="Glutamate--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049940">
        <property type="entry name" value="GluQ/Sye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311:SF2">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="An anticodon-binding domain of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="12">
        <location>
            <begin position="41"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class I anticodon-binding" evidence="13">
        <location>
            <begin position="383"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ43410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="509" mass="58552" checksum="2D022BF590A3C3CE" modified="2009-07-28" version="1">MKLSLPIIRNYSKAGSLLKDSLAELAANSSHLSRQPKTPARTRFAPSPTGFLHLGSLRTALYNYLLAKSTGGEFILRIEDTDKNRLVPGAEDNIINTLKWCNLHIDEGPVEGGPYGPYRQSDRKHIYQKYANELLSKGLAYKCYCSKERLLELRESAQRLKPPTNVTYDRKCISESEHEGLPYVIRFKSPNNYPPFRDLLHGELSLQPQYNDKDRRFDDFVIVKNDGMPTYHFANVIDDHLMKITHVVRGEEWLPSTPKHIAMYHAMGWEPPQYIHIPLLTSLKDKKLSKRSGDLNILKLKDERILPEALVNFVALFGWSPVRSNGEKFNEVMDLSDIIELFSIDQLTKGNAKVNDSKLYYFNKLHLAKKLESAEGLETLVEEYYPHFKQFSNQSKEYLYKLLKFMGPNLTSIHEIETDHQYLFQEIDYSKVKVPNDQTKSVLEYVLENGYYDAINKLPQQGIPKKNIFMSLRYALSGGKSGLAIPHFIELLGEIEFNRRLSNALKTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLF9</accession>
    <name>C4YLF9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">General negative regulator of transcription subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_01677</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01677"/>
    <dbReference type="HOGENOM" id="CLU_028046_1_0_1"/>
    <dbReference type="OMA" id="QGIKMGM"/>
    <dbReference type="OrthoDB" id="1923159at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16618">
        <property type="entry name" value="mRING-HC-C4C4_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12438">
        <property type="entry name" value="RRM_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000257">
        <property type="entry name" value="CCR4-NOT core complex subunit Not4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034261">
        <property type="entry name" value="CNOT4_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039780">
        <property type="entry name" value="Mot2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039515">
        <property type="entry name" value="NOT4_mRING-HC-C4C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14570">
        <property type="entry name" value="zf-RING_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="98"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="2">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="239"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="312"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="499"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="423"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="535"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ43440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="62554" checksum="6888AE43E388BE50" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLJ9</accession>
    <name>C4YLJ9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_01717</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLJ9"/>
    <dbReference type="PaxDb" id="5476-C4YLJ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01717"/>
    <dbReference type="HOGENOM" id="CLU_024324_3_0_1"/>
    <dbReference type="OrthoDB" id="1939479at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF141">
        <property type="entry name" value="GH15225P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ43480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="125" mass="14188" checksum="9CA1CB992D1ABB13" modified="2009-07-28" version="1">MEKILTPINIGNMHWALAVIDNIKKTITYYDSLGGTHNSGNPQAVQTLAHYMKEEAKRLGVMGNEYKLIPHMEAPQQKNGSDCGVFTCTAARYISANKPLSYSQNDMKIIRRRMVYEILDNRLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLN8</accession>
    <name>C4YLN8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial protein import protein MAS5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_01757</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLN8"/>
    <dbReference type="SMR" id="C4YLN8"/>
    <dbReference type="PaxDb" id="5476-C4YLN8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01757"/>
    <dbReference type="HOGENOM" id="CLU_017633_10_0_1"/>
    <dbReference type="OMA" id="RVCPTCV"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000048">
        <property type="entry name" value="DnaJ family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000036">
        <property type="entry name" value="Type I HSP40 co-chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="125"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="125"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ43519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="393" mass="42732" checksum="44AD7AC5B72E7ED4" modified="2010-10-05" version="1">MVKDTKFYDALGVSPNASDAELKKAYRKAALKYHPDKNPSPEAAEKFKELSHAYEILSDDQKREIYDQYGEEGLSGQGAGGFGMNADDIFAQFFGGGFHGGPQRPSRGKDIKHSIACSLEELYKGKTVKLALNKTVLCGECKGRGGAEGKVAQCPDCHGNGMKFVTKQMGPMIQRFQTVCDKCQGTGDLIDPKDRCKKCNGKKTESERKILEVHVKPGMKDGDHITFAGEGDQTPGVTPGDVVFIISQKPHPVFQRKGNDLLIEQEIELATALAGGEIAFKHISGDWVRIEIPAGEVIAPGSIKMVEGFGMPVRTHKGNLIIHFNVKFPENNFADEESLKKLASLLPKPKEVKIPADADVDDCTMVPAKLEQSNPYESDEEAHGGPGVQCASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLV7</accession>
    <name>C4YLV7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial glycine transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Solute carrier family 25 member 38 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_01826</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>glycine(in) = glycine(out)</text>
            <dbReference type="Rhea" id="RHEA:70715"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Mitochondrion inner membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLV7"/>
    <dbReference type="PaxDb" id="5476-C4YLV7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01826"/>
    <dbReference type="HOGENOM" id="CLU_015166_0_3_1"/>
    <dbReference type="OMA" id="WGIYEEL"/>
    <dbReference type="OrthoDB" id="1924968at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904983">
        <property type="term" value="P:glycine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000103">
        <property type="entry name" value="Mitochondrial glycine transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03064">
        <property type="entry name" value="SLC25A38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030847">
        <property type="entry name" value="Hem25/SLC25A38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181:SF3">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="22"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="132"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="269"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ43588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="362" mass="39641" checksum="977CF766095FE1FC" modified="2009-07-28" version="1">MSSPPLSSPVPQVKTTQNGKSPDATVHLLAGAIAGLVSAVTLQPFDLLKTRLQQQQLTTKQEVRTTLTKELKKLTRVKDLWRGTLPSTLRTSIGAGLYFTTLSKMRTSWGEYKQSKDSSINLKSNSSILPKLTAMENLTTGFIARGIVGYITMPITIIKTRFESNLYNYNSMYEGISGIYLDDKKQQQQIRNPSINKGVGGGGSWKNFFKGSVATLARDCPYAGLYVLTYEAFKNDLIPLIIPNSSLSLSSSSSSSSSSSLFVFNDNNRSSIINSTAAVLAASTCTTITAPFDAIKTRLQLTNEEGGSMTTVLKKMLREDGGIKNLFRGLSLRLGRKGISAGISWCIYEELIKSNYFQSKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM00</accession>
    <name>C4YM00_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleolar complex protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_01875</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM00"/>
    <dbReference type="SMR" id="C4YM00"/>
    <dbReference type="PaxDb" id="5476-C4YM00"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01875"/>
    <dbReference type="HOGENOM" id="CLU_011272_0_0_1"/>
    <dbReference type="OMA" id="GCLRYYL"/>
    <dbReference type="OrthoDB" id="10266662at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687:SF4">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="143"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="685"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="685"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="696"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ43631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="714" mass="81487" checksum="E62A8B19C2D8FA3E" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMA4</accession>
    <name>UTP25_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>U3 small nucleolar RNA-associated protein 25</fullName>
            <shortName>U3 snoRNA-associated protein 25</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>U three protein 25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">UTP25</name>
        <name type="ORF">CAWG_01983</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMA4"/>
    <dbReference type="SMR" id="C4YMA4"/>
    <dbReference type="PaxDb" id="5476-C4YMA4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01983"/>
    <dbReference type="HOGENOM" id="CLU_018705_0_1_1"/>
    <dbReference type="OMA" id="GIMIFIP"/>
    <dbReference type="OrthoDB" id="10264378at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002072">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010678">
        <property type="entry name" value="UTP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053939">
        <property type="entry name" value="UTP25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06862">
        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22916">
        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000408108" description="U3 small nucleolar RNA-associated protein 25">
        <location>
            <begin position="1"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="716" mass="82977" checksum="E7F4C2C824AA6CED" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMB4</accession>
    <name>C4YMB4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_01993</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMB4"/>
    <dbReference type="PaxDb" id="5476-C4YMB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01993"/>
    <dbReference type="HOGENOM" id="CLU_028223_2_1_1"/>
    <dbReference type="OMA" id="AYICSYL"/>
    <dbReference type="OrthoDB" id="365981at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020796">
        <property type="entry name" value="ORC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047088">
        <property type="entry name" value="ORC5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048866">
        <property type="entry name" value="ORC5_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14630">
        <property type="entry name" value="ORC5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21639">
        <property type="entry name" value="ORC5_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="ORC5 lid" evidence="9">
        <location>
            <begin position="229"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 5 C-terminal" evidence="8">
        <location>
            <begin position="319"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ43745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="496" mass="57056" checksum="40DE8CD800418C55" modified="2009-07-28" version="1">MSLTLDELTQLKKQVKERDEEIDLLNAFINKNPRLSSPCVIVHGYKSIGKTFTVTKFLKALGTNFSTINCDECVSKKILLRRCFDRIRIDSGCPIGSLNTRNDLAKYGNNGDSFSTFVSALELFVEEFDYKLEHHVLLLDRFDQCFEYVNDLLAGFTRLRESSTILQNFTVVVIISGEDPKEIVTLSNPHVYFKVYNESQIISILQESRLCKFNINDVSDDSTESIEFYNQYVKAIVDMLYPYTGSDMSLLIDFTKRLWDPFIEPIRQGRLQITEFVKCLKEGIHLFTNEDVVSTSGVIEFKTLQWEKQVTHGGHVHDLPLHSKFFLLASYLASYGSYRNDLHKYSKVKVVKYKKRQSTKATSVTKGHMSKESIDTRLLSANYVDLERILAILSVIYRNYAPSLNHSDKDELLYMDDRIIEDEEKKESERSKFTLTRNIDLSNQIATLFSLGLLSKTNSSDILTAKVRWKCNIDWKTAEGIAKSVDFPISDFMMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YML1</accession>
    <name>C4YML1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex subunit NOP10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Nucleolar protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Nucleolar protein family A member 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">snoRNP protein NOP10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_02094</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YML1"/>
    <dbReference type="SMR" id="C4YML1"/>
    <dbReference type="PaxDb" id="5476-C4YML1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02094"/>
    <dbReference type="HOGENOM" id="CLU_184680_1_0_1"/>
    <dbReference type="OMA" id="HRIIIKK"/>
    <dbReference type="OrthoDB" id="13807at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904874">
        <property type="term" value="P:positive regulation of telomerase RNA localization to Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.300:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ43842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="59" mass="6882" checksum="0C4F49711B41BFDD" modified="2009-07-28" version="1">MHLMYTLDAEGKRIYTLKKISEDGEITKSAHPARFSPDDKYSRQRVTLKKRFGLLPTQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMS1</accession>
    <name>C4YMS1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Nitrogen permease regulator 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 4">Required for meiotic nuclear division protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_02155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Vacuole membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the NPR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMS1"/>
    <dbReference type="PaxDb" id="5476-C4YMS1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02155"/>
    <dbReference type="HOGENOM" id="CLU_014314_0_0_1"/>
    <dbReference type="OMA" id="CNLAFRY"/>
    <dbReference type="OrthoDB" id="18648at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056603">
        <property type="entry name" value="HTH_NPRL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005365">
        <property type="entry name" value="Npr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153">
        <property type="entry name" value="CGTHBA PROTEIN -14 GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153:SF5">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24064">
        <property type="entry name" value="HTH_NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03666">
        <property type="entry name" value="NPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GATOR1 complex protein NPRL3 C-terminal HTH" evidence="6">
        <location>
            <begin position="646"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="104"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="562"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="569"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ43902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="715" mass="81890" checksum="6E98034C8501EACB" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN41</accession>
    <name>C4YN41_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphomutase-like protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN41"/>
    <dbReference type="SMR" id="C4YN41"/>
    <dbReference type="PaxDb" id="5476-C4YN41"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02281"/>
    <dbReference type="HOGENOM" id="CLU_039184_0_3_1"/>
    <dbReference type="OMA" id="HGLGVHN"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946895" description="Phosphomutase-like protein 3" evidence="1">
        <location>
            <begin position="20"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="35799" checksum="8E711809E862DE1A" modified="2010-10-05" version="1">MQQFLTLGALWTLFNVATTISLPKYSSSQTYFAQSDPNIPVSQVDDTNNFGLKSQYSWDDVVSNLASNEKLFFLQRHGQGWHNVAPSNFSRVDWNCYWAEQSGRDGVVWEDAELTPKGVQQIQNLHQRIKDTPDFPQPEKFFVSPLRRTLQTWNITWNGLPHKTPLIKEFAREIYGIDSESKRHNKTFIHNYVPSFEFESGFTEQDENWSPDKSESDQHCDYRAAVLLQDIFNDSPDEKVISVVLHSGIIYCLLDVVGHRYFPMATGGAIPVVIAIENYNTDYPLNDAWDTFKDWCPNPPASISGTATSTATGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN55</accession>
    <name>C4YN55_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c lysine N-methyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_02295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN55"/>
    <dbReference type="PaxDb" id="5476-C4YN55"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02295"/>
    <dbReference type="HOGENOM" id="CLU_035838_0_0_1"/>
    <dbReference type="OMA" id="DYINGID"/>
    <dbReference type="OrthoDB" id="441812at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF47">
        <property type="entry name" value="ACTIN-HISTIDINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="292"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ44036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="686" mass="79052" checksum="7D64D6E8218EEA18" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNA1</accession>
    <name>C4YNA1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNA1"/>
    <dbReference type="PaxDb" id="5476-C4YNA1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02341"/>
    <dbReference type="HOGENOM" id="CLU_1440865_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946773" evidence="1">
        <location>
            <begin position="18"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="188" mass="20492" checksum="6D1A739AA9114F54" modified="2010-10-05" version="1">MMLSILAMASASAFNLASNSSCLALSAGLIIPCNHSLLVYLSSWNFLGVGGNKSWIPNFLASLNKSADLSRENFALCQLPDSWFLFGKNGFLNGSVVVDGPSLYCANGRGGYLMKKLCNFWGSLANASLGVSWKDMVWLLFGVCLFFLEKNFSFFLFDYTLGSTIDFYIYSGPSIKHLTAPLPPSTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNB8</accession>
    <name>C4YNB8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_01374</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNB8"/>
    <dbReference type="PaxDb" id="5476-C4YNB8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01374"/>
    <dbReference type="HOGENOM" id="CLU_017584_4_4_1"/>
    <dbReference type="OMA" id="IMAARDY"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510:SF1">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="43"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ43151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="390" mass="43798" checksum="8ED4CA8D535C46E2" modified="2009-07-28" version="1">MVKQEDFAVEQFMDKYETKIEWNMAETCTASLSFNELFELIPDKSVSQSLQQKVFDTRLTYGHIKGSPELKQAIAQLYNDEGGSITADDIVITNGAIGANFLTLYAIVDQGDKVIVVNPTYQQLASVSRVFSGASENIIPWNLNFEDNYLPNLDELQNLVDTHNPKLVIINNPNNPTGVVWGHTIMEKIVGICSAKGIYILCDEVYRPLYHSTDDKPKSIVNYGYEKTISTSSTSKAFALAGLRLGWIVTKDQDIIQKLYSKRDYNTISVSAIDDMLATVALSNYKHILARSYDICQTNLQILEKYIDSTPLLSWVKPKGGSTCFVKVNIDNIDTMDMCVELVEKYKTLIVPGEVFDNKKGYLRIGFGNSTQDIKQGLARLSEYFESKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNC1</accession>
    <name>C4YNC1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_01377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNC1"/>
    <dbReference type="PaxDb" id="5476-C4YNC1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01377"/>
    <dbReference type="HOGENOM" id="CLU_1628330_0_0_1"/>
    <dbReference type="OMA" id="CDLEIHC"/>
    <dbReference type="OrthoDB" id="4031013at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="146" mass="16446" checksum="CFA8F1B66B18D674" modified="2009-07-28" version="1">MEVATSNPQPKPQTINKQVTFQFANECDLEIHCSPFGLSGLYIKINGTDIMGIGSTMGLITGSTRGLIHYNDSNDLIDQKYKLYVVIDDDDMLRIDFTKIYTDASNDNNEKQVQEVPTLVFRGKCPEGRPDTIEPFIGIFSFERET</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNK8</accession>
    <name>C4YNK8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_01470</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YNK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01470"/>
    <dbReference type="HOGENOM" id="CLU_000366_1_1_1"/>
    <dbReference type="OMA" id="FFTIHAQ"/>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000007">
        <property type="entry name" value="Putative E3 ubiquitin-protein ligase HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057948">
        <property type="entry name" value="TPR_TRIP12_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25579">
        <property type="entry name" value="TPR_TRIP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="1342"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="146"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="715"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1276"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="730"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="759"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1276"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ43241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1712" mass="193439" checksum="D577A5CE3B0498FF" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNT4</accession>
    <name>C4YNT4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_02867</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNT4"/>
    <dbReference type="PaxDb" id="5476-C4YNT4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02867"/>
    <dbReference type="HOGENOM" id="CLU_1120560_0_0_1"/>
    <dbReference type="OMA" id="VSAICAM"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ44593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="253" mass="28005" checksum="57E5E954026D494A" modified="2009-07-28" version="1">MNNDITTIVPATRFDLLGPLKIFFQKNVFCTLLPVGIHFAAWTMVLTSLSTELESRYHYSVMHVGLIYLPQGIACIAGSLVVGKSLDWYYRYRKTIYDQEVECLPLDERPQFNIVATRLTLSVVPALLMIIGLVIFGWCIQYKRHIISIIISTILVSFSASVFIAICTTMLVDLYPNNGSGSTSCLNLMRCWLAALGAGVLDSMINAMNVGGTYTVVAGFCILFDLALIYVLHNAKKKFSNSGPTTTKSPPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNV0</accession>
    <name>C4YNV0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_02883</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNV0"/>
    <dbReference type="PaxDb" id="5476-C4YNV0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02883"/>
    <dbReference type="HOGENOM" id="CLU_028277_2_0_1"/>
    <dbReference type="OMA" id="KLYCLLQ"/>
    <dbReference type="OrthoDB" id="537032at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="9">
        <location>
            <begin position="134"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="353"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ44609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="430" mass="50637" checksum="1198E577939CBD5D" modified="2009-07-28" version="1">MSSGSIATTTIPSTPMSIESIEDHQYHNSFLAMVERNQIPLSRNLLIILYLSHLLLQNNNTTITPYTSKFIHIQNCVGIDEFTGKSIYDIDINDTYFVIHSLVIVTFLRSFLMKWCFEPFASKFCHIHSKKAKTRFAEQSWSFVYYSISFIFGVVLYWDSPYYNNLDQVYINWPNHYMSWEFKTYYLVSMGFWLQQIFVLNVEKPRKDHYQMFSHHIITCLLIIGSYYYYYFRIGHLILMIMDSVDIFLAAAKMLKYAGFSNACDAMFLLFLVSWIVLRHGVYNYIFYHAWYKSVDLMKNGQCVEGLMQKRCWTPVVIDTFLGLLGGLQIITCIWMYLILKVAYKVVTGSGAEDVRSDEDDTDIELEEEEEEEEEEEEEEEVGQPIFVEKKEEEVVLEIEEDKYSFERDSFSSSSESTLDEKKDIRKRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNV3</accession>
    <name>C4YNV3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA/pantothenate metabolism flavoprotein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPC synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNV3"/>
    <dbReference type="PaxDb" id="5476-C4YNV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02886"/>
    <dbReference type="HOGENOM" id="CLU_042326_2_1_1"/>
    <dbReference type="OMA" id="YQSRTMD"/>
    <dbReference type="OrthoDB" id="70224at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/pantothenate metabolism flavoprotein C-terminal" evidence="2">
        <location>
            <begin position="58"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="209" mass="24304" checksum="57A5ED513BD1F513" modified="2010-10-05" version="1">MTEKDNKIQINDQFADEMLQVWRKYNEAKDTNSLLLIPFTTVNQYLYTLKEISENLHIMKSKALFYLAAAVSDFFIPQSRMPQHKIQSSATQDGELVIRLAQVPKFLSRLVENWAQGAMIISFKLETDNNILIQKAESALERYHHQLVIGNLLQTRKKEVVFVTPGHHQENWIRLTDQEINDNVEIESKMIPAVIKVHDDWIAKNDNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNW3</accession>
    <name>C4YNW3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_02896</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNW3"/>
    <dbReference type="PaxDb" id="5476-C4YNW3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02896"/>
    <dbReference type="HOGENOM" id="CLU_008279_6_1_1"/>
    <dbReference type="OMA" id="VECNRCA"/>
    <dbReference type="OrthoDB" id="2020758at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02662">
        <property type="entry name" value="Peptidase_C19F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="116"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="547"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="686"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="553"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="696"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="712"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="727"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="779"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ44622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="812" mass="91209" checksum="0B7468E923C1BB7B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNY1</accession>
    <name>C4YNY1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_02914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNY1"/>
    <dbReference type="PaxDb" id="5476-C4YNY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02914"/>
    <dbReference type="HOGENOM" id="CLU_076697_0_0_1"/>
    <dbReference type="OMA" id="MMIPGRP"/>
    <dbReference type="OrthoDB" id="19619at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024621">
        <property type="entry name" value="Mba1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012483">
        <property type="entry name" value="Mba1_Saccharomycetales"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13333">
        <property type="entry name" value="M-AAA PROTEASE-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13333:SF5">
        <property type="entry name" value="M-AAA PROTEASE-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07961">
        <property type="entry name" value="MBA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022613">
        <property type="entry name" value="MBA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ44640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="291" mass="33213" checksum="208F9E49FEFDB207" modified="2009-07-28" version="1">MFSVKRSVIGISKQSSLPKSFISSQISIRSNSSSSTPDNDNVKRKKAGMDISKVPLPYIGVMSDFYVPPKLTTCPITSWPKLITRRIMLFALNTYNIVKFKREIGVPLEFNAWKDKGIENYVRANKVFAQACSEPQLKAKASLLRRKLDHSCGKHLIESLSARSLSFPEDSKLNWEWKSIQNNPKVVLFNIIPDADGIACFVQFILKLKTNQKISIVKDQKVVKEQESSVEDYLVYSMNPISKELLLVGKLFESDHIRGLKPEMDVFDQKLMQRFLKTSSDIYRTDPKQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNY2</accession>
    <name>C4YNY2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Elongator complex protein 3</fullName>
            <ecNumber evidence="15">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAWG_02915</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="15 16">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ELP3 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="15"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNY2"/>
    <dbReference type="SMR" id="C4YNY2"/>
    <dbReference type="PaxDb" id="5476-C4YNY2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02915"/>
    <dbReference type="HOGENOM" id="CLU_025983_2_1_1"/>
    <dbReference type="OMA" id="TFETRPD"/>
    <dbReference type="OrthoDB" id="10265243at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000003">
        <property type="entry name" value="Elongator complex protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15 16" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="81"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="17">
        <location>
            <begin position="395"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEQ44641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="547" mass="62364" checksum="BBD4D5E0872F2049" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP00</accession>
    <name>C4YP00_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Presequence protease, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Pitrilysin metalloproteinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_02934</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running. Preferentially cleaves the N-terminal side of paired basic amino acid residues. Also degrades other unstructured peptides. May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer and homodimer; homodimerization is induced by binding of the substrate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M16 family. PreP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YP00"/>
    <dbReference type="MEROPS" id="M16.013"/>
    <dbReference type="PaxDb" id="5476-C4YP00"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02934"/>
    <dbReference type="HOGENOM" id="CLU_009165_0_0_1"/>
    <dbReference type="OMA" id="FPFQVHY"/>
    <dbReference type="OrthoDB" id="10250783at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000013">
        <property type="entry name" value="Mitochondrial presequence protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000148">
        <property type="entry name" value="Mitochondrial presequence protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000009">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000011">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055130">
        <property type="entry name" value="PreP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF13">
        <property type="entry name" value="PRESEQUENCE PROTEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22516">
        <property type="entry name" value="PreP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16C associated" evidence="16">
        <location>
            <begin position="509"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ44659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1034" mass="117498" checksum="960AD01CC5880514" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP05</accession>
    <name>C4YP05_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YMC020W-like alpha/beta hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YP05"/>
    <dbReference type="PaxDb" id="5476-C4YP05"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02940"/>
    <dbReference type="HOGENOM" id="CLU_010834_1_0_1"/>
    <dbReference type="OMA" id="NIEKNWP"/>
    <dbReference type="OrthoDB" id="5598028at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058934">
        <property type="entry name" value="YMC020W-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058933">
        <property type="entry name" value="YMC020W-like_ab_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349:SF1">
        <property type="entry name" value="AER328WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26147">
        <property type="entry name" value="AB_HYDROLASE_YMC0-YMC35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YMC020W-like alpha/beta hydrolase" evidence="2">
        <location>
            <begin position="346"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="751" mass="84297" checksum="7B2D1F832BB04B74" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP24</accession>
    <name>C4YP24_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Maltose/galactoside acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_02959</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YP24"/>
    <dbReference type="SMR" id="C4YP24"/>
    <dbReference type="PaxDb" id="5476-C4YP24"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02959"/>
    <dbReference type="HOGENOM" id="CLU_051638_3_0_1"/>
    <dbReference type="OMA" id="CVILDCN"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03357">
        <property type="entry name" value="LbH_MAT_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF54">
        <property type="entry name" value="ACETYLTRANSFERASE, CYSE_LACA_LPXA_NODL FAMILY (AFU_ORTHOLOGUE AFUA_2G08430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Maltose/galactoside acetyltransferase" evidence="4">
        <location>
            <begin position="99"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ44683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="307" mass="34600" checksum="677E74B79CED8EFE" modified="2010-10-05" version="1">MCSFTPPPSPPPRREEKSSVYKSGQNSSTPNSYKIFHPPPPTYSIYKTLPNMPTFKDKEDFVKQTNVRAEKNQELIKFARDNLNHLPFTEKDGGAWENYERMISGMLYNCLQKELETTRMSCRDYMLDYGSFRTRDYKTTQEFLDAKYKHLESFIGHVGKNAFMEYPIYFDYGFNTYLGDNFYSNYNLTILDVSIVRIGNNVKCGPNVSILTPTHPVDPTLRYDQLENALPVTVGNGVWLCGSCTILGGVTVGDGSIVAAGAVVNKDVPPNTVVAGVPARVVKQLEPRDPNFDTMAVLKQYGMGYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP58</accession>
    <name>C4YP58_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_03000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YP58"/>
    <dbReference type="PaxDb" id="5476-C4YP58"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03000"/>
    <dbReference type="HOGENOM" id="CLU_069054_1_0_1"/>
    <dbReference type="OMA" id="IHGKTNL"/>
    <dbReference type="OrthoDB" id="1938621at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000011">
        <property type="entry name" value="Iron-sulfur assembly protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="3">
        <location>
            <begin position="107"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ44717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="232" mass="25603" checksum="6D88B895C9FA7EA1" modified="2009-07-28" version="1">MLGTKYFAISKRILTLKSFKPLTLGGTTIITLRYNSTKPSTTTTNSNANSSRLKPSSFAFPSSPTSQQSSSTTTSTNDSITSSQQQEDINDFRATKLIHGKTNLSFAITERASKKLNEISQQDNQDSGLLIQVESGGCHGFQYNLKLTNIDKELQQQQDGDANDLVVFERDQGRKVIMNESSLMILQDSKLDYTKELIGIQFKIVDSPYTSSACGCGSSFDFDFDKLSQKEG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-03" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP90</accession>
    <name>OCA5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>Oxidant-induced cell-cycle arrest protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">OCA5</name>
        <name type="ORF">CAWG_03037</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the OCA5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YP90"/>
    <dbReference type="PaxDb" id="5476-C4YP90"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03037"/>
    <dbReference type="HOGENOM" id="CLU_028817_0_0_1"/>
    <dbReference type="OMA" id="LRFKVWP"/>
    <dbReference type="OrthoDB" id="27140at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000408207" description="Oxidant-induced cell-cycle arrest protein 5">
        <location>
            <begin position="1"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="100"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="132"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="555"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="636"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="647"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="717" mass="81986" checksum="51896A764DD992BC" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPC1</accession>
    <name>C4YPC1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Histone transcription regulator 3 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_03074</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPC1"/>
    <dbReference type="PaxDb" id="5476-C4YPC1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03074"/>
    <dbReference type="HOGENOM" id="CLU_001316_0_0_1"/>
    <dbReference type="OMA" id="WETWYRL"/>
    <dbReference type="OrthoDB" id="77564at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033053">
        <property type="entry name" value="Hir3/CABIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502:SF7">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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</entry>
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        </source>
    </evidence>
    <sequence length="599" mass="67796" checksum="29A14A64418B63DF" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPP1</accession>
    <name>C4YPP1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tubulin-folding cofactor D ARM repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPP1"/>
    <dbReference type="PaxDb" id="5476-C4YPP1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02442"/>
    <dbReference type="HOGENOM" id="CLU_011301_0_0_1"/>
    <dbReference type="OMA" id="ATNFICW"/>
    <dbReference type="OrthoDB" id="10253476at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058033">
        <property type="entry name" value="ARM_TBCD_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23579">
        <property type="entry name" value="ARM_TBCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25767">
        <property type="entry name" value="ARM_TBCD_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="1">
        <location>
            <begin position="290"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="935" mass="109005" checksum="9A894331112A67B3" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPQ0</accession>
    <name>AIM24_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">AIM24</name>
        <name type="ORF">CAWG_02451</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIM24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPQ0"/>
    <dbReference type="PaxDb" id="5476-C4YPQ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02451"/>
    <dbReference type="HOGENOM" id="CLU_040665_0_0_1"/>
    <dbReference type="OMA" id="NGPYDLQ"/>
    <dbReference type="OrthoDB" id="5295771at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959:SF2">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000399570" description="Altered inheritance of mitochondria protein 24, mitochondrial">
        <location>
            <begin position="31"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="475" mass="52737" checksum="E3A7E46B25A9B235" modified="2009-07-28" version="1" precursor="true">MSLNQYIRPVRTKLSHISFIRNISITQSSINTTIKNDESISKTTTIPENIQQAKELAGYRALEIPEFKTLGSAEGTTATATGSSSILSINVPPSVPVYIRRGSLLSIYGIQEISSIDSVRSQLQFPNFWKRLIYGGYVSGYQKLISTTPFSLLISSKSRSSGSGSGSGFEKSFVNLVLDGTTDWAILDKSALQVYTGNSLSITMHKLPKFISKKLSRSLKKDKKSKTNTNKLETGLFSWKKLGYTLLSGRGKVGLVGNGSSSGYGSSIYNINLNQNEEILINKNNLLGITVNGPYDLQNCIVKYEFPIINNANPTNTNTNINIKEPVTIVKPKLIQPTTWNLIVLKLKNFNNGFKKIFQIINKYTLGLKTTSYNYLAGNQDFIKVIGPRNLLLQSNTNKSHRGFYNIIPRNKPQAKVWPTNQTTTKVDESSSFSTPKDYLNYVTIEPGKGAVFKSTLDFSETVESIENKNKNKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ10</accession>
    <name>C4YQ10_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome c oxidase subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_02564</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ10"/>
    <dbReference type="PaxDb" id="5476-C4YQ10"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02564"/>
    <dbReference type="HOGENOM" id="CLU_169147_2_1_1"/>
    <dbReference type="OMA" id="WWRHPRS"/>
    <dbReference type="OrthoDB" id="5511599at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039297">
        <property type="entry name" value="COX7a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02238">
        <property type="entry name" value="COX7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ44299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="59" mass="6871" checksum="602EFD1B97A2F166" modified="2009-07-28" version="1">MNPQRIIELQKHYQNTPKPLWLRGRQSAFLVYPFYALFAVSTAIPLYYSVRAVAGIKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ44</accession>
    <name>C4YQ44_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Serine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_02598</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="3"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ44"/>
    <dbReference type="SMR" id="C4YQ44"/>
    <dbReference type="PaxDb" id="5476-C4YQ44"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02598"/>
    <dbReference type="HOGENOM" id="CLU_023797_0_1_1"/>
    <dbReference type="OMA" id="GYTPCFR"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.40:FF:000003">
        <property type="entry name" value="Serine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000026">
        <property type="entry name" value="Seryl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="16">
        <location>
            <begin position="153"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="279"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="295"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="366"/>
            <end position="369"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="13">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ44333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="462" mass="52991" checksum="9111C72CF7B37CDF" modified="2009-07-28" version="1">MLDINAFLVEKGGDPEIIKASQKKRGDSVELVDEIIAEYKEWVKLRFDLDEHNKKLNSVQKEIGKRFKAKEDAKDLIAEKEKLSNEKKEIIEKEAEADKNLRSKINQVGNIVHESVVDSQDEENNELVRTWTPENYKKPEQIAAATGAPAKLSHHEVLLRLDGYDPERGVRIVGHRGYFLRNYGVFLNQALINYGLSFLSSKGYVPLQAPVMMNKEVMAKTAQLSQFDEELYKVIDGEDEKYLIATSEQPISAYHAGEWFESPAEQLPVRYAGYSSCFRREAGSHGKDAWGIFRVHAFEKIEQFVLTEPEKSWEEFDRMIGCSEEFYQSLGLPYRVVGIVSGELNNAAAKKYDLEAWFPFQQEYKELVSCSNCTDYQSRNLEIRCGIKQQNQQEKKYVHCLNSTLSATERTICCILENYQKEDGLVIPEVLRKYIPGEPEFIPYIKELPKNTTSVKKAKGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ51</accession>
    <name>C4YQ51_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_02605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ51"/>
    <dbReference type="PaxDb" id="5476-C4YQ51"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02605"/>
    <dbReference type="HOGENOM" id="CLU_044733_0_0_1"/>
    <dbReference type="OMA" id="NERYYIC"/>
    <dbReference type="OrthoDB" id="2150604at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ44340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="54309" checksum="E3EBC29A1FF99077" modified="2009-07-28" version="1">MLIQPNHRRKPEFNERYYICRTIENYSTNFSIIVQYNRQISHNLLSNALYSLIKKNSWFVQNFFQIDQRNPATANGHNFEVRILEHVKFNDVVKFHQIDKFDEIIMESLNDHIFSMNNATLPLWKINVFEEMRPNGNQFISVSFDHSNYDGLSGVQFQKDLAKELSTAKDDLFYDVLFDYQRDFGNLPAKILPAVDNLTDLFDLGVLSSSSSILKKWVPFYDTICGFIWPSDPPIFDTDTPVTKNLQTKYKFLKLTSNQIGQISKYCRSHGITLTTYFDIICICALQETVFSVVKSSATHTSSLVAINGRRYYSDEIKNFLYGTLVCGAPIILPTIENKLEAMQIFHQEMTNDINTKKSFQSTGNLLKHANVWEYFQNKINKIGGRFTLTISNLGKISNSNDIFKFEQMYFVSNTGVVYNFVLNITTLPNGELTAVVGYIPEFEKYELNNKPIMDTFIEKFYDLLILTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ83</accession>
    <name>C4YQ83_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_02639</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ83"/>
    <dbReference type="PaxDb" id="5476-C4YQ83"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02639"/>
    <dbReference type="HOGENOM" id="CLU_036005_0_1_1"/>
    <dbReference type="OMA" id="NNWHTDV"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000008">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF9">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE (AFU_ORTHOLOGUE AFUA_3G01010)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="114"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ44372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="423" mass="48340" checksum="9A89F1DFB848B0AA" modified="2009-07-28" version="1">MAPTAVIQEPEDVQETIKRLAGLKVIGHSKNSKGIITGYDPEWADKLPETTKQRYAKYGVDISKGYPYVPVNEKVPKFVDEVFAIRNEEYPYIERGKNADPEKKSLFDAAEDVIHLTPYIGTEIVGLQLSELTEQQRDELALLIAERVVVFFKDQDLSPQKQLELGHYWGQVEVHPQATRIGEEYDGISVIWQEQQRDRWGLNLTFKQSKKGNSQWHSDLVHEKQTAGITHLHLDAIPGIGGETLWSSTYGAYDKLSPALQKFLDGKTAIYRSAHQYLDRNDPLKGPKYVEREHPIVRTHPVTGWKYLFVNRSMTVRIVGLLPEESDLILNYLYSVIETNRDIQVRWSWQKELGSVKNNKKDEPKQYRGVSALWDNRISNHSVVHSEESIVGRHGTRVTSLADTGYYDPNSKSQRESLGLSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQC2</accession>
    <name>C4YQC2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uracil permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_02679</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQC2"/>
    <dbReference type="PaxDb" id="5476-C4YQC2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02679"/>
    <dbReference type="HOGENOM" id="CLU_021555_2_2_1"/>
    <dbReference type="OMA" id="YEAFAGP"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF2">
        <property type="entry name" value="ALLANTOIN PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ44411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="570" mass="64350" checksum="270A6FF81727B90F" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQH4</accession>
    <name>C4YQH4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_02732</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in cell wall beta(1-&gt;6) glucan synthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KRE9/KNH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQH4"/>
    <dbReference type="PaxDb" id="5476-C4YQH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02732"/>
    <dbReference type="HOGENOM" id="CLU_063732_1_0_1"/>
    <dbReference type="OMA" id="YYYFQIY"/>
    <dbReference type="OrthoDB" id="2432613at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045328">
        <property type="entry name" value="Kre9/Knh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008659">
        <property type="entry name" value="Kre9/Knh1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154:SF1">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05390">
        <property type="entry name" value="Kre9_KNH1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944393" evidence="4">
        <location>
            <begin position="22"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="6">
        <location>
            <begin position="27"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1 C-terminal" evidence="5">
        <location>
            <begin position="166"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ44463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="271" mass="29126" checksum="F4AF946B0FCC7448" modified="2009-07-28" version="1">MRQFQIILISLVVSIIRCVVADVDITSPKSGETFSGSSGSASIKITWDDSDDSDSPKSLDNAKGYTISLCTGPTSDGDIQCLDPLVKNEAIAGKSKTVSIPQNSVPNGYYYFQIYVTFTNGGTTIHYSPRFKLTGMSGPTATLDVTETGSVPADQASGFDTATTADSKSFTVPYTLQTGKTRYAPMQMQPGTKVTATTWSMKFPTSAVTYYSTKAGTPNVASTITPGWSYTAESAVNYASVAPYPTYWYPASERVSKATISAATKRRRWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQS5</accession>
    <name>C4YQS5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydrophilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQS5"/>
    <dbReference type="PaxDb" id="5476-C4YQS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04422"/>
    <dbReference type="HOGENOM" id="CLU_098355_0_0_1"/>
    <dbReference type="OMA" id="GTHRYGK"/>
    <dbReference type="OrthoDB" id="4094978at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944882" description="Hydrophilin" evidence="2">
        <location>
            <begin position="19"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="13744" checksum="35A6C75EE07BD9AA" modified="2009-07-28" version="1">MKFTTVATVFAISSLAAAKGGEKDHGKASTVTKYVTETTHRYGRFDKTSRSQKPKETGTHRYGKFNKTPRPVTTTVLVKESDLPKKRDAVVARDSKNASSNSTTSSGNNGVATGVSLGLAGVLAVGAALVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQT9</accession>
    <name>C4YQT9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein bS6m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_04436</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQT9"/>
    <dbReference type="SMR" id="C4YQT9"/>
    <dbReference type="PaxDb" id="5476-C4YQT9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04436"/>
    <dbReference type="HOGENOM" id="CLU_126331_3_0_1"/>
    <dbReference type="OMA" id="HQIGDYW"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15465">
        <property type="entry name" value="bS6_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000007">
        <property type="entry name" value="37S ribosomal protein Mrp17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_bS6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="Ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ46092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="119" mass="13510" checksum="191CC90F3F7A773B" modified="2010-10-05" version="1">MYYELFAIARITDPLNTAKEATKIASTVGKLILNNRGIIRDITSLGAKPLPQIISKEQERHFQGYHFIIGFDSSPNVQTQLLRTLRRDPRILRSSIMKHDLTHNLNPGTTIEQALRATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRD6</accession>
    <name>C4YRD6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04635</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRD6"/>
    <dbReference type="PaxDb" id="5476-C4YRD6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04635"/>
    <dbReference type="HOGENOM" id="CLU_025603_1_1_1"/>
    <dbReference type="OMA" id="YFQVDNP"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052630">
        <property type="term" value="F:UDP-N-acetylgalactosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019276">
        <property type="term" value="P:UDP-N-acetylgalactosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000072">
        <property type="entry name" value="UDP-N-acetylglucosamine diphosphorylase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ46289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="486" mass="54644" checksum="1D1E646BA89A7DE7" modified="2009-07-28" version="1">MTVKSQQQIIDSFKQANQDQLFQYYDSLTIDQQQEFIDQLSTIEEPAKLISTVEQAIQFSQTNSTSRNFTQLPNEQTASTLDLSKDILQNWTELGLKAIGNGEVAVLLMAGGQGTRLGSSAPKGCFNIELPSQKSLFQIQAEKILKIEQLAQQYLKSTEKPIINWYIMTSGPTRNATESFFIENNYFGLNSHQVIFFNQGTLPCFNLQGNKILLESKNSICQSPDGNGGLYKALKDNGILDDLNSKGIKHIHMYCVDNCLVKVADPIFIGFAIAKKFDLATKVVRKRDANESVGLIVLDQDNQKPCVIEYSEISQELANKKDPQDSSKLFLRAANIVNHYYSVEFLNKMIPKWISSQKYLPFHIAKKKIPSLNLKNGEFYKPTEPNGIKLEQFIFDVFPSVELNKFGCLEVDRLDEFSPLKNADGAKNDTPTTCRNHYLERSSKWVIQNGGVIDNQGLVEVDSKTSYGGEGLEFVNGKHFKNGDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRP2</accession>
    <name>C4YRP2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_04745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRP2"/>
    <dbReference type="PaxDb" id="5476-C4YRP2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04745"/>
    <dbReference type="HOGENOM" id="CLU_056292_1_0_1"/>
    <dbReference type="OMA" id="FENQENP"/>
    <dbReference type="OrthoDB" id="421671at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025638">
        <property type="entry name" value="DUF4336"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835">
        <property type="entry name" value="YALI0C07656P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="31728" checksum="8E41FBD1FAA2A31B" modified="2010-10-05" version="1">MSNESSLKASIRKINDNAVTISTPHTVFRILNFGARMSLINFDGNVIIYSPMKYDQEVFDKAIKVLFENQENPQYEVKYVIAANDEHNLWAHVYKEKFGSKIIAGENCKLKSNCKADYVVTSKIYNKAIKGSMWQDELNVSDPFMQSLELIGLGNHVIHDLELFDTTTKTLYVGDSIYNLGVPGTTSGNVILEQYSPELGYAKGYNPHGWFSFLTRYLQPDSIICRYLANYAAGTKTKEGKEAIQTVYNWDFDKLVMIHGNVIEKDGKDAWKKLFASSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRW5</accession>
    <name>C4YRW5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Manganese/iron superoxide dismutase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRW5"/>
    <dbReference type="SMR" id="C4YRW5"/>
    <dbReference type="PaxDb" id="5476-C4YRW5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04822"/>
    <dbReference type="HOGENOM" id="CLU_057349_1_1_1"/>
    <dbReference type="OMA" id="MTAREPN"/>
    <dbReference type="OrthoDB" id="275227at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="128"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="214"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="262" mass="30772" checksum="C5272A97E0C8B9B2" modified="2010-10-05" version="1">MFNSISRGVFASSTRFTRVARFLHQVPKLESHETWTQEGIPGFLSPKGYNLAWTDYQNYLLTNLTLLTNGTSSEYKTPYQTLLHTAKQTTQQHVFHYASMAHNNHFFFQQLDTKENASKTKPSRFLMEKLMHEDILDLDQLRNKLLTMAENTYGQGWIFLVETEDKNLKFINCHNDGTPYYYAKQQLLDLNGGIDEGNFSYLENLKSRALNNEKDYTLPILAINYWDYMYIPDYGVTGKSDYLNKLWDHINWDVVNKRLFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS17</accession>
    <name>C4YS17_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein MSS2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS17"/>
    <dbReference type="PaxDb" id="5476-C4YS17"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04875"/>
    <dbReference type="HOGENOM" id="CLU_047859_0_0_1"/>
    <dbReference type="OMA" id="WFKLGME"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="48585" checksum="595CAEAE0373C3DE" modified="2009-07-28" version="1">MIRQFLRNASSNATKATISTTSSLSATTNNNYVNTPEQQRQEQRPELLTILPSKRILNRILFDIDSQLTYKQMIPILNHIYKNLSTPESINLNQLKIQSSYDLMKFKKLLQEIRKVTNSINVHLLDLENELIEQSAELGNNDAITILAFETVRKRQILKEIVDEEDYQHANELIKQLIDINHPLVFKMAGDLSWELNQPNQAIEYWQTYIQLASNKNSDGDDYDDHLCQIYYNMGYYYFTYLKHPNLTLAKLNFQKCINHGFGGGGGSSGGNSNEFIVKSHFYLGQLYVNTNPKLSKYHWEISSSSGLKDSIINLGFLEMNCFQNYNLAIEWFKLGVELNPNEVQCLIGLFDAYIALQNWKSANIYLSKLNKLFETITEKKKKTSELPESIKSSIIYNESMLKTFHETRLNDIKLVTSKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSD5</accession>
    <name>C4YSD5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_04998</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSD5"/>
    <dbReference type="PaxDb" id="5476-C4YSD5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04998"/>
    <dbReference type="HOGENOM" id="CLU_078883_0_0_1"/>
    <dbReference type="OMA" id="EEGPYWP"/>
    <dbReference type="OrthoDB" id="1564555at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06465">
        <property type="entry name" value="p23_hB-ind1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000055">
        <property type="entry name" value="HSP90 associated co-chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="6"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ46638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="218" mass="23570" checksum="30BE56AC14BA4E76" modified="2009-07-28" version="1">MSSTTTQTPTVLWAQRSSEDDAAKNIIYLTIQISDPIDLKIDLKSDHLIIDSKSNDSVYSSIDYHLQIDFFKEIDPDQSKINTENGSHIFMILRKKDQQEEYWPRLTKEKLKYHYIKTDFDKWVDEDEQDEVKDDPNDFGGPGGPGGAMDFSQMLSGMGGLGGAGGSGGPGGVDLSALASQLGQAGGAGGAAGLDGEEGDEEAKEAQEESNATATEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSF4</accession>
    <name>C4YSF4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_05019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSF4"/>
    <dbReference type="PaxDb" id="5476-C4YSF4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05019"/>
    <dbReference type="HOGENOM" id="CLU_170036_0_0_1"/>
    <dbReference type="OMA" id="MYTHIST"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="115" mass="13665" checksum="F00B5827396C04E9" modified="2009-07-28" version="1">MYTHISTDYREALEYITIVRKTIQLYHVKFNFKTMSHSLSITWFNYHPSIYNRQNPLNFSKNTLFEIRRCNNGCDITYCYILHGASTAFNRMSNFKRVIPLDACINLSLKHYPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSH4</accession>
    <name>C4YSH4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSH4"/>
    <dbReference type="PaxDb" id="5476-C4YSH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05040"/>
    <dbReference type="HOGENOM" id="CLU_013933_3_1_1"/>
    <dbReference type="OMA" id="VHQLNNA"/>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="628"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="628"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="643"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="652" mass="74735" checksum="2D5A3A9A372DAD35" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSR2</accession>
    <name>C4YSR2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosome subunit biogenesis protein NIP7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_05130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with pre-ribosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NIP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSR2"/>
    <dbReference type="SMR" id="C4YSR2"/>
    <dbReference type="PaxDb" id="5476-C4YSR2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05130"/>
    <dbReference type="HOGENOM" id="CLU_097217_0_0_1"/>
    <dbReference type="OMA" id="LISMGTC"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.220:FF:000001">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="8">
        <location>
            <begin position="95"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ46765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="181" mass="20611" checksum="19CFE645ECD37552" modified="2009-07-28" version="1">MRPLTEEETKVVFEKLANYIGRNISFLIDNPENPHVFRLQKDRVYYVQESIAKFATSVSRQQLMSLGTCFGKFTKTGKFRLHITSLPYLAQYAKFKIWIKQNGEMPFLYGNHVLKAHIGRMSDDIPEHAGVIIYSMNDIPLGFGASAKSTAEARNLPPTGIVAFRQGDIGEYLREEDTLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSW6</accession>
    <name>C4YSW6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2415 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSW6"/>
    <dbReference type="PaxDb" id="5476-C4YSW6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05661"/>
    <dbReference type="HOGENOM" id="CLU_027079_0_0_1"/>
    <dbReference type="OMA" id="RPGHQSG"/>
    <dbReference type="OrthoDB" id="418169at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019417">
        <property type="entry name" value="DUF2415"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF9">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10313">
        <property type="entry name" value="DUF2415"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2415" evidence="2">
        <location>
            <begin position="395"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ47102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="572" mass="64167" checksum="849312DF74794B35" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSW8</accession>
    <name>C4YSW8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Lipase</fullName>
            <ecNumber evidence="12">3.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_05663</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:12045"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the AB hydrolase superfamily. Lipase family. Class Lip subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="12"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSW8"/>
    <dbReference type="ESTHER" id="canal-LIP8">
        <property type="family name" value="Fungal-Bact_LIP"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YSW8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05663"/>
    <dbReference type="HOGENOM" id="CLU_029538_5_0_1"/>
    <dbReference type="OMA" id="RDHASEH"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.130:FF:000001">
        <property type="entry name" value="Lipase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR029171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ47104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="460" mass="49846" checksum="8B7C07883E6A9D97" modified="2009-07-28" version="1">MLFLLFLLITPIYAGLIFLTKPSNDPFYNPPKGFEKAAVGEILQSRATPKSITGRFAPLKIQNSWQLLVRSEDSFGNPNAIVTTVIQPFNADPSKVASYQVFEDSAKGDCAPSYALQFGSDLSTLATQAETFLLAPLLEQGYYVVSPDYEGPKSTFTIGKQSGQAVLNSIRATLKSSKITNIKEDAKVVMWGYSGGSLASGWAAALQPSYAPELSSSLLGAALGGFVTNITATAQAADGTVFAGIVANALGGVANEYPEFKSILQSDTDKKSVFDEFDSHCLADGVIDYINTSFLIGDNKIFKTGWDILKSPTIAKIVEDNGLVYQKQLVPKIPIFVYHGSIDQIVPIVNVKKTYQNWCEGGISSLEFAEDGTNGHLTETVVGAPAALTWIIDRFNGKQTVSGCQHDKRLSNFQYPNISSSILKYFKVTLDTMMSNGLGSDIQKDKITPDDLRKFLLGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT34</accession>
    <name>C4YT34_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_05732</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT34"/>
    <dbReference type="PaxDb" id="5476-C4YT34"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05732"/>
    <dbReference type="HOGENOM" id="CLU_003886_0_0_1"/>
    <dbReference type="OMA" id="SFHYVFH"/>
    <dbReference type="OrthoDB" id="361693at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001176">
        <property type="entry name" value="Karyopherin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="27"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ47170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="980" mass="113991" checksum="EA88F45272F47FF1" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT46</accession>
    <name>C4YT46_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_05745</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT46"/>
    <dbReference type="SMR" id="C4YT46"/>
    <dbReference type="PaxDb" id="5476-C4YT46"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05745"/>
    <dbReference type="HOGENOM" id="CLU_001265_2_2_1"/>
    <dbReference type="OMA" id="FRERTFI"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000247">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF29">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ47182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="62982" checksum="E373490549C87570" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT60</accession>
    <name>C4YT60_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription elongation factor SPT6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">Chromatin Elongation factor SPT6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Transcription elongation factor spt6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_05759</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPT6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YT60"/>
    <dbReference type="HOGENOM" id="CLU_001680_0_1_1"/>
    <dbReference type="OMA" id="GYFYLCF"/>
    <dbReference type="OrthoDB" id="995477at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09928">
        <property type="entry name" value="SH2_Cterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09918">
        <property type="entry name" value="SH2_Nterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2740:FF:000002">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000065">
        <property type="entry name" value="Transcription elongation factor SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2740">
        <property type="entry name" value="Spt6, Death-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.850">
        <property type="entry name" value="Spt6, helix-hairpin-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028083">
        <property type="entry name" value="Spt6_acidic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042066">
        <property type="entry name" value="Spt6_death-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032706">
        <property type="entry name" value="Spt6_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028088">
        <property type="entry name" value="Spt6_HTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035420">
        <property type="entry name" value="Spt6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035018">
        <property type="entry name" value="Spt6_SH2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035019">
        <property type="entry name" value="Spt6_SH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028231">
        <property type="entry name" value="Spt6_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055179">
        <property type="entry name" value="Tex-like_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017072">
        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145:SF6">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14635">
        <property type="entry name" value="HHH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14641">
        <property type="entry name" value="HTH_44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14633">
        <property type="entry name" value="SH2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14632">
        <property type="entry name" value="SPT6_acidic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22706">
        <property type="entry name" value="Tex_central_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14639">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="SH2" evidence="15">
        <location>
            <begin position="1204"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080336"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="649" mass="72339" checksum="BC0C67924AC1C60D" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTM7</accession>
    <name>C4YTM7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar sorting protein Vps3844 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_05522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTM7"/>
    <dbReference type="PaxDb" id="5476-C4YTM7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05522"/>
    <dbReference type="HOGENOM" id="CLU_050724_0_0_1"/>
    <dbReference type="OMA" id="NKCNSHG"/>
    <dbReference type="OrthoDB" id="5583277at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053065">
        <property type="entry name" value="Archenteron_Induction-Rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024382">
        <property type="entry name" value="Vps3844_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36853:SF1">
        <property type="entry name" value="DUF3844 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36853">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12955">
        <property type="entry name" value="Vps3844_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944460" description="Vacuolar sorting protein Vps3844 C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar sorting protein Vps3844 C-terminal" evidence="3">
        <location>
            <begin position="291"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ46968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="393" mass="44258" checksum="ABA38B471B68F18B" modified="2009-07-28" version="1">MKWVNLLSWFSLFISSFALAESDSKHKHQQRRHDSNVYLLSNGKVVSNDDTTLLTKHEAMTYLDTFLELDEPYVKLGDNDQLIDLLNGLWDTKKLGSPKLIVNVKGEDLDATPMFKTKHLPLHKLMKNLVTNVPSVQLYKLTPELKYVTTIDNEVDSSSLVHHFNYFTEKLDSIWKQFNAKHQQESQSYTPTNDKLFINELSQLIHLGEKINHTTGKSTDVFFFEVSSLLSIKRKIGSSSTTFIHAKEAMTDLLLKLSQTFDIVVVTFPQIQELSHLNKRNVELSVKSFQYGTQAACEVATNKCNSHGKCTQVGDNWACQCEPSFNKTTSKTTTWVGHDCSKKDVSVEANLFLWTSIALVVILVGGIQLMFGIGNDPLPGVLDAATIPKKSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTR2</accession>
    <name>C4YTR2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_05557</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTR2"/>
    <dbReference type="SMR" id="C4YTR2"/>
    <dbReference type="PaxDb" id="5476-C4YTR2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05557"/>
    <dbReference type="HOGENOM" id="CLU_026126_7_2_1"/>
    <dbReference type="OMA" id="KPGHLEC"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000276">
        <property type="entry name" value="Glutaredoxin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF26">
        <property type="entry name" value="GRX1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="5">
        <location>
            <begin position="35"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ47003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="123" mass="14179" checksum="8B6A6182B9F11655" modified="2009-07-28" version="1">MSSILAWGFNLWYQPPPPTAQTEKEIEHTINSHKIVIYSKTYCPFCDQTKHLLNEQYPQESYEVINLNILDDGLTIQNQLYANTGQYMVPIIFINGQHVGGNSEVQQLHTNGKLQELLNPQKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTV0</accession>
    <name>C4YTV0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTV0"/>
    <dbReference type="PaxDb" id="5476-C4YTV0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05596"/>
    <dbReference type="HOGENOM" id="CLU_090369_0_0_1"/>
    <dbReference type="OMA" id="IRRFQCY"/>
    <dbReference type="OrthoDB" id="4025417at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="260" mass="29713" checksum="1AE60546D7C1A8D5" modified="2009-07-28" version="1">MNHYPISSSSTSSTSISSINSNNYNYLNSITMTKCKLLPTKTISRGKFRGINDIRRFQCYNSQCNLNFNEYQLCKYCAHVPYVSSPLRIKVKNNLNDDEEYNTGRTGNNNNNKQYRSIKIDYIPPTRSNAIIRRNSSYINNNNNNNNNNKLIVPHSVTTLGTTNSNGSNGNGDLTSKLNEFWDHLEMGKLQIKQRFMDIKIQKHKLSFKKRSFSAPPMVLRNDNDTTTNNNNNNNNENIYYSTGTSTSDYSTTTTTTTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCZ0</accession>
    <name>C4YCZ0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_00377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCZ0"/>
    <dbReference type="PaxDb" id="5476-C4YCZ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00377"/>
    <dbReference type="HOGENOM" id="CLU_016174_1_1_1"/>
    <dbReference type="OMA" id="FERENAY"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32212">
        <property type="entry name" value="CYCLIN-LIKE F-BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32212:SF248">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ42176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="630" mass="72459" checksum="7761A0BAA0A982ED" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD12</accession>
    <name>C4YD12_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin-like protein ARP6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Actin-like protein arp6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_00400</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family. ARP6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD12"/>
    <dbReference type="SMR" id="C4YD12"/>
    <dbReference type="PaxDb" id="5476-C4YD12"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00400"/>
    <dbReference type="HOGENOM" id="CLU_027965_1_1_1"/>
    <dbReference type="OMA" id="FFEEYEC"/>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10210">
        <property type="entry name" value="ASKHA_NBD_Arp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000040">
        <property type="entry name" value="Actin-like protein ARP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ42198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="446" mass="50916" checksum="993B4B11B09513CB" modified="2009-07-28" version="1">MPEQLQKLVIDNGSYTIKAGFNTGDDDGNDTSTPIKVTNAISKTKDGIIHVGNQYLSHTNNFSGIQFRRPFEQNNLTSWETEKPIWDYTLDNLLLQTNDQSQSTSSSSSSSLQKHKRGKVIDPDDIHLILTEQPYQLPQLSTNTDQIIFEEYGFNKYYRCIAPSLVPFSVDTNQINDDFVLVIDSGFNSTWIVPMIYQQIHWPAVKKLPIGGNLLNGLLREMISFRHYDISEDPILINTIKESTCFISSSNYQQDLQHKHDLMCEFVLPDFKLTITGFVKNENSMSSQKLPNDTQVLKLYDERFTVPETYFHPEIIFDNNRTTASSSLLNNAPFKNLTDLIVESIMACPSITQPLLSANICLSGGSTNIPNFKTRLIGELRKELPSNWKVNIFDKQYDINRDELSWYGGINLSNESELLQEISISKKDYFEHGANWCQQQFGFKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD56</accession>
    <name>C4YD56_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD56"/>
    <dbReference type="PaxDb" id="5476-C4YD56"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00446"/>
    <dbReference type="HOGENOM" id="CLU_026648_1_0_1"/>
    <dbReference type="OMA" id="PYQMKLT"/>
    <dbReference type="OrthoDB" id="2011986at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018810">
        <property type="entry name" value="UPF0662"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086:SF1">
        <property type="entry name" value="CU(2+) SUPPRESSING AND BLEOMYCIN SENSITIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086">
        <property type="entry name" value="UPF0662 PROTEIN YPL260W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10303">
        <property type="entry name" value="DUF2408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="452" mass="52198" checksum="7D3F29CBC25445D0" modified="2009-07-28" version="1">MTYSGLVTPHSRPTTPSFGLNSNAATSATSTGPSNSSSGSTPKVIVPSYEKPIHESLSQIYKTLLELKNNRSKYINSKQIYKIYHEFLDILNELKVTRKDEELKGITLNLPNTNDLITDDIFQLLSLCFVTCGLTKFAPATYSSLSTVMKLLNHLKECKVYTVEDLAPIGIRLAEIRDIVISTTNYEEDDDEDEEEEANRHANHQIEETLLRNKLIKCETLYQDLESNFKNVPKDLEPTYNKLIELRKNILNYMISYKDEKSNAGKNLIKHEKLTIKINQFKAELKKIEQYRDETDMKFHSNDVSDLDEQKLESLQAIMNGLIDECNNLLGDLLAQDDSDEISSSLSSLHLNEESQELKAKYDSIYHQLQDLKLTLENLLITRRWTLRETDLYSYQKQLKTFDEQRLNLVKQTNKDDTKAFKKSQLLILFLLRRCYGLVYKLWRVVNSLVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD86</accession>
    <name>C4YD86_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha</fullName>
            <ecNumber evidence="4">2.5.1.58</ecNumber>
            <ecNumber evidence="3">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CAAX farnesyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FTase-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ras proteins prenyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Type I protein geranyl-geranyltransferase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_00476</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="4"/>
    <dbReference type="EC" id="2.5.1.59" evidence="3"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD86"/>
    <dbReference type="SMR" id="C4YD86"/>
    <dbReference type="PaxDb" id="5476-C4YD86"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00476"/>
    <dbReference type="HOGENOM" id="CLU_026582_1_0_1"/>
    <dbReference type="OMA" id="HRHTIID"/>
    <dbReference type="OrthoDB" id="272289at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.120:FF:000009">
        <property type="entry name" value="CAAX geranylgeranyltransferase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF1">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ42272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="306" mass="36601" checksum="BC42924AC96DD920" modified="2009-07-28" version="1">MTDSKYDYSDITPVDINTEEPQICQILYDEDYKQIMGLLLALMKAEEYSERALHITELGINELASHYTIWIYRFNILKNLPNRNLYDELDWCEEIALDNEKNYQIWNYRQLIIGQIMELNNNDFDPYREFPILEAMLSSDPKNHHVWSYRKWLVDTFDLHNDAKELSFVDKVIDTDLKNNSAWSHRFFLLFSKKHLATDNTIDEELNYVKDKIVKCPQNPSTWNYLLGIHERFDRSITQLEEFSLQFVDLEKDQVTSSFALETLAKIYTQQKKYNESRTVYDLLKSKYDPIRSNFWDYQISKLTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDD0</accession>
    <name>C4YDD0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fun14p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_00523</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FUN14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDD0"/>
    <dbReference type="PaxDb" id="5476-C4YDD0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00523"/>
    <dbReference type="HOGENOM" id="CLU_103433_0_0_1"/>
    <dbReference type="OMA" id="NIIHIPW"/>
    <dbReference type="OrthoDB" id="3990500at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346">
        <property type="entry name" value="FUN14 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346:SF0">
        <property type="entry name" value="RE45833P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ42316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25443" checksum="370ABD11C940ACA1" modified="2009-07-28" version="1">MFARSPFISTIFKRSIGSVRTTTTGTGTTTIPKQYQLFNFNNLITNFKSSSLRSSYGGSSNYSSSSSNNSNNTLKLLFASAGSSFLLLFTFARKIHNDTGSLTQYQQQQQQSSLDLSISKQQPLQKQYHESRFSNYLNYEELTIGSVVGLFLGVIIGKLSQVIVFVSLSSYFLIEFLENKNIIHIPWNYFITIGKEKINLKQLFFEKPSFKISFVLSFIIAAYNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDJ3</accession>
    <name>C4YDJ3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_00588</name>
        <name evidence="12" type="ORF">CAWG_05923</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2006-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Giovannoni S.J."/>
                <person name="Cho J.-C."/>
                <person name="Ferriera S."/>
                <person name="Johnson J."/>
                <person name="Kravitz S."/>
                <person name="Halpern A."/>
                <person name="Remington K."/>
                <person name="Beeson K."/>
                <person name="Tran B."/>
                <person name="Rogers Y.-H."/>
                <person name="Friedman R."/>
                <person name="Venter J.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">WO-1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDJ3"/>
    <dbReference type="SMR" id="C4YDJ3"/>
    <dbReference type="PaxDb" id="5476-C4YDJ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00588"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05923"/>
    <dbReference type="HOGENOM" id="CLU_007265_3_5_1"/>
    <dbReference type="OMA" id="AIRDMGM"/>
    <dbReference type="OrthoDB" id="3969558at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000211">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ42379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ47353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="458" mass="50012" checksum="C737C498FE923B09" modified="2009-07-28" version="1">MGKEKTHVNVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDKLKAERERGITIDIALWKFETPKYHVTVIDAPGHRDFIKNMITGTSQADCAILIIAGGTGEFEAGISKDGQTREHALLAYTLGVKQLIVAVNKMDSVKWDKNRFEEIIKETSNFVKKVGYNPKTVPFVPISGWNGDNMIEPSTNCPWYKGWEKETKSGKVTGKTLLEAIDAIEPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGIIKAGMVVTFAPAGVTTEVKSVEMHHEQLAEGVPGDNVGFNVKNVSVKEIRRGNVCGDSKNDPPKGCDSFNAQVIVLNHPGQISAGYSPVLDCHTAHIACKFDTLVEKIDRRTGKKLEENPKFVKSGDAAIVKMVPTKPMCVEAFTDYPPLGRFAVRDMRQTVAVGVIKSVEKSDKAGKVTKAAQKAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDM8</accession>
    <name>C4YDM8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">CAWG_00625</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDM8"/>
    <dbReference type="PaxDb" id="5476-C4YDM8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00625"/>
    <dbReference type="HOGENOM" id="CLU_004875_2_1_1"/>
    <dbReference type="OMA" id="IRYYCSE"/>
    <dbReference type="OrthoDB" id="63989at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09769">
        <property type="entry name" value="Luminal_IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10422">
        <property type="entry name" value="RNase_Ire1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000572">
        <property type="entry name" value="Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000443">
        <property type="entry name" value="Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010513">
        <property type="entry name" value="KEN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06479">
        <property type="entry name" value="Ribonuc_2-5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51392">
        <property type="entry name" value="KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="17" id="KW-0834">Unfolded protein response</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="768"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="domain" description="KEN" evidence="24">
        <location>
            <begin position="1092"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="437"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="632"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="978"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="667"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="696"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="722"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EEQ42414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1198" mass="136112" checksum="1DE21E202FDAECA8" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDP0</accession>
    <name>C4YDP0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase ECO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Establishment of cohesion protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_00637</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. ECO subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDP0"/>
    <dbReference type="SMR" id="C4YDP0"/>
    <dbReference type="PaxDb" id="5476-C4YDP0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00637"/>
    <dbReference type="HOGENOM" id="CLU_039183_2_1_1"/>
    <dbReference type="OMA" id="PSITHQE"/>
    <dbReference type="OrthoDB" id="428854at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028005">
        <property type="entry name" value="AcTrfase_ESCO_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028009">
        <property type="entry name" value="ESCO_Acetyltransf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13880">
        <property type="entry name" value="Acetyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13878">
        <property type="entry name" value="zf-C2H2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="N-acetyltransferase ESCO zinc-finger" evidence="12">
        <location>
            <begin position="13"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase ESCO acetyl-transferase" evidence="13">
        <location>
            <begin position="185"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ42426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="260" mass="29519" checksum="6E94E2245D8C013D" modified="2009-07-28" version="1">MGSINSQKAQKIQSILALPSNFKKITCSTCDMTYNPHISQDKLLHNKYHTNFINGIPWNYKTDNDVLIIENFTLVETPKLNSTGKSLKSTKTRHTFKGSIICINKSNKRHIQKVELLLSMVNQELNASQDSGQWKKPEFDKSKAFVIIIDNKAIGLCTTDTIQPDQGRWMIHKTQSIVPNQINRNVVIGISRIWISRKWRQYGLGKKLLNVVLKNSIYSVQLLKNQVAFSQPSFSGGMLAKSFNGVKHKSGEMLLPVYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YE00</accession>
    <name>C4YE00_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_00749</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YE00"/>
    <dbReference type="PaxDb" id="5476-C4YE00"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00749"/>
    <dbReference type="HOGENOM" id="CLU_004219_2_0_1"/>
    <dbReference type="OMA" id="PLINCHN"/>
    <dbReference type="OrthoDB" id="427368at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048591">
        <property type="entry name" value="WDHD1/CFT4_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ctf4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDHD1/CFT4 second beta-propeller" evidence="6">
        <location>
            <begin position="199"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 helical bundle" evidence="7">
        <location>
            <begin position="515"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="90"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ42536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="625" mass="70933" checksum="BF17D61F0AE4DE6E" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YE29</accession>
    <name>C4YE29_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_00779</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OMA" id="ITLSWLH"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:mating projection tip"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="PX_Bem1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000124">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035550">
        <property type="entry name" value="Bem1/Scd2_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
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    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF2">
        <property type="entry name" value="SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="44"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="159"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="226"/>
            <end position="255"/>
        </location>
    </feature>
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        <location>
            <begin position="405"/>
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        </location>
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            <end position="424"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ42565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="433" mass="49105" checksum="B575059AC7563FF1" modified="2009-07-28" version="1">MSKLRQHSITTSPLVISSPTFSAPIRSLTISNPQQSSTISSNLRGNVILVTKYDFVAEGENEISVNKGDLVKLIDRLGNGWVLVKYIDRVQPPGLIPASYVDIAVNDQTNPITLTWLQKDDDDSEQQPTSQAHIDNIIDELNYLDLQFNKVESKFVTINNRPYPIQASISNFLLFNGRIWYRLDIEYSDKSKSYICRYYQDFYNLHIKLLDLYEILSKIEARNSVANSGGGGGSRGDTIKLPKLPEPIPTQNNDDENKEISMLLKRCNELNIYINKLILNKYYQTSDQLRDWLEVRDLPGFIINSFDNEDEKDEQIDKMTNDEINEKILPGSINIVKNYYEKLEELEELEKQKQVQQLKDSKLPQRSQSKNIYNNYQQAAHAMAGHTNSIKHKMVMSKTGTIRHIPVGSRSASVSVSRSGSGTSPAGGSKSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YED9</accession>
    <name>C4YED9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_00896</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42675.1"/>
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    <sequence length="324" mass="37963" checksum="417866F9525163CD" modified="2009-07-28" version="1">MQDSYTLLRQRQKVDNSQTSTELESTPLSKRLHYYHELDEWQQDNHFIKSGYVKQTNSYKECFKSLTYLHNESVNIYSHLLPSSISFWVILYYINYILPKYDNYLGVWEKLNFLQFGLACTFCMFMSSTFHCIKAHSHPVSKFGNQLDYFGIVILITCSLMSIILFAYYDYPWYRNIFVGLSLFFGTVCTVLTLDRKFSTNEYRPFRSFMFILFGLSGALPIVNSMYMFGFEITRQKAGVEWLILEGVFYIGGAVLYAARVPERFTHVEDDEHTLLNNPSSGTFDIFGHSHQIFHVMVVIAAFCHWKGLVQSYHYLHLQTLPNL</sequence>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Lin M.F."/>
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                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
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                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
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        <source>
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    </evidence>
    <sequence length="701" mass="77419" checksum="9924C9682B0BED49" modified="2009-07-28" version="1"> </sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ42696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="885" mass="100105" checksum="39C6094EB67FC33F" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEJ9</accession>
    <name>C4YEJ9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_00956</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEJ9"/>
    <dbReference type="SMR" id="C4YEJ9"/>
    <dbReference type="PaxDb" id="5476-C4YEJ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00956"/>
    <dbReference type="HOGENOM" id="CLU_004962_0_5_1"/>
    <dbReference type="OMA" id="MCLKVKY"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000005">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="114"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ42735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="314" mass="35899" checksum="9D9577F956F7580F" modified="2010-10-05" version="1">MGERGPDQWLEQIKNCISLSESDMKQLCELVKELLMEESNIQPVQSPVTVCGDIHGQFHDLLELFRTAGGLPSDDNQTNFIFLGDYVDRGYFSLETFTLLMVLKVKYPHRITLVRGNHESRQITQVYGFYEECLTKYGSTTVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRAQEVPHEGGFCDLVWSDPDNIDTWAVSPRGAGWLFGSKVSREFNHINNLQLIARAHQLVMEGFRYHFKEKDVVTVWSAPNYCYRCGNVASVMQVDEDLEPNFKIFSAVQDGDLSVKNNANKQQRSDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEM0</accession>
    <name>C4YEM0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Macro-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_00977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEM0"/>
    <dbReference type="PaxDb" id="5476-C4YEM0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00977"/>
    <dbReference type="HOGENOM" id="CLU_058081_0_0_1"/>
    <dbReference type="OMA" id="YIIHCPT"/>
    <dbReference type="OrthoDB" id="6082470at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ42756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="35540" checksum="81AF0987F16DCD39" modified="2009-07-28" version="1">MKFIFIDNNPLIVKCWKHHYQVLSNIYKEYNFSSHHNIKFNFYNHTIEHMVQNYNFNNTGNTGKTSIVTPANSLNYMGGGFDLHLLNAILLGTNHTFKQLENIIQNHQLQKFQGYLVPNQIYKINLPDLTGFEYKSSLVYQNWNLIEIIEIPTMVVPEKIHSISHLFDCIWNLMNNIDFTKEEEEEEEEKEEEEGGEENVLVLPGIGTGYGNLNEYESTKIMLFAIFLYNLSLRGKTTPTTRLDQLKKSLLILFFFNKDYRKLENLNDIEELETNVISEYGKNLNLVNGTVMELEEVFKCIRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEP2</accession>
    <name>C4YEP2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_01000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEP2"/>
    <dbReference type="PaxDb" id="5476-C4YEP2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01000"/>
    <dbReference type="HOGENOM" id="CLU_040309_0_0_1"/>
    <dbReference type="OMA" id="ANFYIDI"/>
    <dbReference type="OrthoDB" id="4010961at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ42778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="498" mass="57732" checksum="6FBF6D7218339B96" modified="2009-07-28" version="1">MFRRIHPILSKQSNALQTLKSGIIFRPLSFITKPTTSTTLRTTPKIISHTLIQSRTLMSTKTSNLGPFKFTLQILTGVYCGLLIVSFGSCYLLYSDANQRQNIPFELSLDDHINAVMAINKDDVCESPRHATKHYRRLLIDLAKQELGDTTTIDESKFDNRYDVPILSTDFLIHNKSIKFINFYIDMILRYSKCLLSKGELDIAIKMLTRIVVDDDFIFFKLGDAEKLSSSSRVLAKITPDITKKISILQRSIDMLIETNKSMQIDNDYILLENSKISDELINCLNDLASNLAKLSQSQSQGQQELLNQSLQIYLSELRSLQTIRSKIESNQANQATYPLFNVDRANLIGMINTIKAHISEIMWVKGHKDKAINFSEQILQELYYDRYSDPKFGPILLNVLNNLEIMYHNLHKPEDVKRCQNLKHDISIYEIRNRFDIPWYDRVMKRISKTIYLRTPIGLVEKGLRDRFEPRARVKELDEFEDEDDENRSQWLYPLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YES0</accession>
    <name>C4YES0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribophorin II C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_01028</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YES0"/>
    <dbReference type="SMR" id="C4YES0"/>
    <dbReference type="PaxDb" id="5476-C4YES0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01028"/>
    <dbReference type="HOGENOM" id="CLU_079423_1_0_1"/>
    <dbReference type="OMA" id="SIVTHYV"/>
    <dbReference type="OrthoDB" id="432292at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056790">
        <property type="entry name" value="Ribophorin_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008814">
        <property type="entry name" value="Swp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640">
        <property type="entry name" value="RIBOPHORIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25147">
        <property type="entry name" value="Ribophorin_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041375026" description="Ribophorin II C-terminal domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II C-terminal" evidence="9">
        <location>
            <begin position="165"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ42806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="275" mass="30905" checksum="97B24FB6882469C2" modified="2010-10-05" version="1">MKTSVFIAIFNLLVCALAYTDLTGSIKINDKKITLGEFNTQEVKQLTINSPKDIIEIDLKSKDIKGKPEQIMVSLADVKNPAISTHYVPVVKESKIKLNIKALSIPEVLKTKDKLVLTIVIADSKSKNNMIRRLVEVLPSPEFKSTSRYQAKPRIGIQPEIHHIFREDERTVNPIVPVVFIIAAFTLLLGLFGSWVGFIGIDNLFRTFKTISKVQLLHNVSFLISVLGFELNFVKYYLGQSIFTTLFYGFILSIPCVYFGVSVLRSLAKNRALGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YES4</accession>
    <name>C4YES4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED17</name>
        <name evidence="10" type="ORF">CAWG_01032</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YES4"/>
    <dbReference type="PaxDb" id="5476-C4YES4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01032"/>
    <dbReference type="HOGENOM" id="CLU_023188_1_0_1"/>
    <dbReference type="OMA" id="PKINDKR"/>
    <dbReference type="OrthoDB" id="5319830at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019313">
        <property type="entry name" value="Mediator_Med17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114:SF7">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10156">
        <property type="entry name" value="Med17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ42810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="565" mass="65624" checksum="83425514B29F6002" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEW9</accession>
    <name>C4YEW9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pre-rRNA processing protein TSR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_01078</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TSR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEW9"/>
    <dbReference type="PaxDb" id="5476-C4YEW9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01078"/>
    <dbReference type="HOGENOM" id="CLU_074896_0_1_1"/>
    <dbReference type="OMA" id="QSNWGGP"/>
    <dbReference type="OrthoDB" id="263560at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10273">
        <property type="entry name" value="WGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="144"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ42855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="208" mass="23898" checksum="8D74BD982254933D" modified="2009-07-28" version="1">MATTIDPTDYVEVENGTLAFSDPKQQAKFELGVCMAIYKWEELTTAVDNLWGGPKSAEKRDWISGIIIDLFAESKIVDIQLIEETLLYAMVDEFDTQIDNDSALEIGNLIVKLYRDAAQEKYGLIDEMYEKWQAKQNTKNFHKVHVEDDPNNPDVSSDEKEEDDDGEEEEIQDDNMMEIDEPEQPRQQNAPIVDDDGFELVQSKGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEX3</accession>
    <name>C4YEX3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_01082</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEX3"/>
    <dbReference type="SMR" id="C4YEX3"/>
    <dbReference type="PaxDb" id="5476-C4YEX3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01082"/>
    <dbReference type="HOGENOM" id="CLU_075696_1_0_1"/>
    <dbReference type="OMA" id="IQKNHFR"/>
    <dbReference type="OrthoDB" id="10264538at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000003">
        <property type="entry name" value="60S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_eL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018256">
        <property type="entry name" value="Ribosomal_eL13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01104">
        <property type="entry name" value="RIBOSOMAL_L13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ42859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="202" mass="23054" checksum="572232714BA0B4F4" modified="2009-07-28" version="1">MAISKNLPLLNNHFRKHWQERVRVHFDQAGKKASRRQSRLRKAAKIAPRPIDALRPVVRAPTVKYNRKVRAGRGFTLAELKAVGIAPKYARTIGISVDHRRQNKSQETFDANVARLQEYKSKLVIFDKKTKASEVASFEQVDVSATFPVEQPAPESGLRAVEVPEQTAYRTLRLARNEKKYKGIREKRAKEKAEAEAEKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEZ0</accession>
    <name>C4YEZ0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA-binding protein VTS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_01099</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Monomer. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEZ0"/>
    <dbReference type="PaxDb" id="5476-C4YEZ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01099"/>
    <dbReference type="HOGENOM" id="CLU_443421_0_0_1"/>
    <dbReference type="OMA" id="LHKYTDC"/>
    <dbReference type="OrthoDB" id="2155283at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09556">
        <property type="entry name" value="SAM_VTS1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000136">
        <property type="entry name" value="Protein VTS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037635">
        <property type="entry name" value="VTS1_SAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="SAM" evidence="9">
        <location>
            <begin position="617"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="468"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="516"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="530"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="574"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ42876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="679" mass="74702" checksum="6A396506C6F38554" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFC6</accession>
    <name>C4YFC6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1746 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFC6"/>
    <dbReference type="PaxDb" id="5476-C4YFC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01242"/>
    <dbReference type="HOGENOM" id="CLU_921408_0_0_1"/>
    <dbReference type="OMA" id="VKYCHSA"/>
    <dbReference type="OrthoDB" id="4083114at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="33551" checksum="A6B107CA88B69807" modified="2009-07-28" version="1">MTTRFNLPGTFPIDDEIPSAPANTTYSTVSSTATELIESQQNFQFNNNQLIHNKTKYQFDILTQIDALVYIIIFYQFVKFCHSACLIPLILHLVLQILLNSKIVTQNSQVPNLLSFLSNEDNQDTRERIYETFIHKYCYLLYIKTILVILYHTLFVATWVMYLVDTQQLQKLNHGTWWFISFIGEETPVIDKSTPYWLKLLELGLFQLIFTDVLILFLQLALYQCIYKQSDAFHLDRRLNEKEVYIIRTNADSTSGIDDQSVVTDADGVPTVLKIRLFECFKSDAYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFI8</accession>
    <name>C4YFI8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_01306</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFI8"/>
    <dbReference type="PaxDb" id="5476-C4YFI8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01306"/>
    <dbReference type="HOGENOM" id="CLU_677918_0_0_1"/>
    <dbReference type="OMA" id="FQGCIQP"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ43069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="406" mass="46165" checksum="27C58413A8DF8A36" modified="2009-07-28" version="1">MFYVFDLTSNETIATDTSQAHELQPTTTPSNQQHIKLRTILNTSKRSRTGCLQCRARKKKCNEEHPVCGSCKRRKVNCSWRVTSKFKILKNGHQENSTSSEEIQESNYTRVDNQSTNDDPPDQNILRGSDKALHQKSDNTDIISLDKNLSSISPKYLSEPGYDFSDLSFLEHCIPSPINSHIFQPFKYLNVQGLYFLDGFIANVAKKFSIGHESSNYILKTFYQLSEEHEAVSYALAAWGGIFIEGGFTENVNHFLGEAIFKMSQEYPNLNNISKKDVYILLNYYLVYIGLQVCAGDVSQWHQIFHRTIDLVKRQGGLSSIIEMFDCSNEIKWLLSDIQYHDILSSNTFQKGTMLPMEEYNSVFKEAKILELGNYGLDPFQGCIQPIYLVLGEITSSAVDLLTSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG52</accession>
    <name>C4YG52_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_00170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YG52"/>
    <dbReference type="PaxDb" id="5476-C4YG52"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00170"/>
    <dbReference type="HOGENOM" id="CLU_1517677_0_0_1"/>
    <dbReference type="OMA" id="WPVMQRP"/>
    <dbReference type="OrthoDB" id="4009691at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ41976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="180" mass="19527" checksum="B8468B0BD70F54A9" modified="2009-07-28" version="1">MLNFVEVNVFGLPITIGKSLSNNGIKVKDVSDSAEEWPWPVMQRPLKQGTSVAYDRYSGVYLNGVKLSENDVSDGCYGLKIGKSCCIGVYSSDDAAKKSKHEIDTTINVSREEFSSKVDPNKIRRIILHSNGTTDIQYISSGNVNPGSFGVASGSWSTVLSSECLEVSESNTSVDVSELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG54</accession>
    <name>C4YG54_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_00172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YG54"/>
    <dbReference type="PaxDb" id="5476-C4YG54"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00172"/>
    <dbReference type="HOGENOM" id="CLU_016174_1_0_1"/>
    <dbReference type="OMA" id="CIPEYID"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ41978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="569" mass="65671" checksum="84BA217C4FBBEA56" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG67</accession>
    <name>C4YG67_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_00185</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YG67"/>
    <dbReference type="PaxDb" id="5476-C4YG67"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00185"/>
    <dbReference type="HOGENOM" id="CLU_040685_0_0_1"/>
    <dbReference type="OMA" id="QGMLKVH"/>
    <dbReference type="OrthoDB" id="289162at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19494">
        <property type="entry name" value="Elp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ41991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="446" mass="49237" checksum="1AC2D263279DAC8A" modified="2009-07-28" version="1">MSFRKRGEIIGGSPAPNRGPIASIPARAPGIAGRAPPLGRTPPAVTGKGITTTTTSSFQLKSKPKSIEKDNATQIMQNPGVRPSLVTSQPTTSTGSSDLDKILLHQGLPLGNSLLIEESGTTDFSSVLLRAFASQGILHNRISNDINAHVIVLGMNQQWANDLPGVYKGSSKEQKKAKIIENESKVSVSNLSNAPSTTNRTTTDPNLKIAWRYGLNKKPESKDENESSNSYEHYNNQFDLTQKLVPGPNPQDISFLPLNAEFNNMVNQISSIIKNQLRSNPTKVIRLIIPSILNPSLYHPSCSSSTFIVPFIHSLRSLVRRFPNNLVLVCSISLDLYPKDSSLLLFIQSLFDAIIHLQPFNQEMTQLLEKAYKNEPTKIQQGLVNIIKIPILSEKGLMMVHDGEYAFKNGRKKFEIEEWSIPVEDDSKDDTHQTQEGGTTTKNIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGA6</accession>
    <name>C4YGA6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_00227</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG101 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGA6"/>
    <dbReference type="PaxDb" id="5476-C4YGA6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00227"/>
    <dbReference type="HOGENOM" id="CLU_069661_1_1_1"/>
    <dbReference type="OMA" id="VCWEIWT"/>
    <dbReference type="OrthoDB" id="10259639at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012445">
        <property type="entry name" value="ATG101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292:SF0">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07855">
        <property type="entry name" value="ATG101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ42030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="161" mass="18403" checksum="346017C34469937D" modified="2009-07-28" version="1">MNVSYPMANNLPDLDSLIDEKVNRILNQITEVSNQAKINVQFLSKSSNKKKTGWFGNSTYNAQDDLVVWESWLINVESLPLDQVSNGESKNVQTSIQNFANNLTRIYDIADKFKEHIPPITSLDSAPFPYKIIIPEKKSDHNRDYHTGEEGWGTYIKKILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGC8</accession>
    <name>C4YGC8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EEQ44810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGC8"/>
    <dbReference type="PaxDb" id="5476-C4YGC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03104"/>
    <dbReference type="HOGENOM" id="CLU_008694_1_0_1"/>
    <dbReference type="OrthoDB" id="4097129at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="666" mass="77534" checksum="C75DC19BCF3FD19A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGD6</accession>
    <name>C4YGD6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ubiquitin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_03112</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGD6"/>
    <dbReference type="SMR" id="C4YGD6"/>
    <dbReference type="PaxDb" id="5476-C4YGD6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03112"/>
    <dbReference type="HOGENOM" id="CLU_010412_2_0_1"/>
    <dbReference type="OMA" id="GVFMAFH"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000008">
        <property type="entry name" value="Ubiquitin-40S ribosomal protein S27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ44818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="151" mass="17268" checksum="EFC26253DF15F6D9" modified="2010-10-05" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGGKKRKKKVYTTPKKIKHKHRKHKLAVLTYYKVDNEGNVERLRRECPAPTCGAGIFMANMKDRQYCGKCHLTLKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGK4</accession>
    <name>C4YGK4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_03183</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YGK4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03183"/>
    <dbReference type="HOGENOM" id="CLU_025028_3_1_1"/>
    <dbReference type="OMA" id="FIYKHNV"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012404">
        <property type="entry name" value="UCP036436"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036436">
        <property type="entry name" value="UCP036436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ44886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="406" mass="45442" checksum="759F873035D99A14" modified="2009-07-28" version="1">MGFGLYLIVAGTLITGAANSLLTKYQDNQCVDNCHDPNPANHKLFEQPGIQTMQMFLGELSMYLVFVFYKWYNYDNNNNNRYVQLNDDDENDPSSVAKPHETSIFENFKLSIPAICDLSCTTLLNIGLVYTPVSIYQMSRGSVVLFVATLSVLFLKRKITKLEWSSLFLVTLGIGLVGLSGSRNTTPDPSSNINNSTNPNPNPALVIFGIFLIISATLLQGIQFVVEEHILAKNPIIPLQLIYIEGFYGLSLMIIISILLNFIIGSIESPENFQSSPFNLSLAIYQVFHNKRILISSLLISLSIAIFNYCGLSITHRISATARSTVDTCRTLIVWIVAMSMKWESFQSLQFCGFVVLVFGTLCFNGVLNPENWGFIPSWLKNDANDSSHERLIDVVDEIDEPIERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGL0</accession>
    <name>C4YGL0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_03189</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGL0"/>
    <dbReference type="SMR" id="C4YGL0"/>
    <dbReference type="PaxDb" id="5476-C4YGL0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03189"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OMA" id="WAPKVRI"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05352">
        <property type="entry name" value="MDH-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF13">
        <property type="entry name" value="L-XYLULOSE REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ44892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="280" mass="29878" checksum="ABFA091C75A3D297" modified="2009-07-28" version="1">MSKETTSYTNAKLGPLPTKAATIPDNILDAFSLKGKVASVTGSSGGIGWAVAEGYAQAGADVAIWYNSHPADDKAEYLTKTYGVKSKAYKCNVTDFQDVEKVVKQIESDFGTIDIFVANAGVAWTEGPEIDVKGVDKWNKVVDVDLNSVYYCAHVVGPIFRKKGKGSFIFTASMSASIVNVPQLQAAYNAAKAGVKHLSKSLSVEWAPFARVNSVSPGYIATHLSEFADPDVKSKWLQLTPLGREAKPRELVGAYLYLASDAASYTTGADLAVDGGYTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGN1</accession>
    <name>C4YGN1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_03211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGN1"/>
    <dbReference type="PaxDb" id="5476-C4YGN1"/>
    <dbReference type="HOGENOM" id="CLU_373368_0_0_1"/>
    <dbReference type="OMA" id="ARRSNIG"/>
    <dbReference type="OrthoDB" id="2149224at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032065">
        <property type="term" value="P:maintenance of protein location in cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13365">
        <property type="entry name" value="PH_PLC_plant-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053005">
        <property type="entry name" value="Nuclear_Pos-Cytoskel_Interact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024774">
        <property type="entry name" value="PH_dom-Mcp5-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190:SF1">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12814">
        <property type="entry name" value="Mcp5_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="552"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="708"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ44913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="744" mass="84021" checksum="8ECC2D489C0F1F43" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGN4</accession>
    <name>C4YGN4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Tryptophan synthase</fullName>
            <ecNumber evidence="5 13">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_03214</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the TrpB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="5 13"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGN4"/>
    <dbReference type="SMR" id="C4YGN4"/>
    <dbReference type="PaxDb" id="5476-C4YGN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03214"/>
    <dbReference type="HOGENOM" id="CLU_016734_2_1_1"/>
    <dbReference type="OMA" id="VDTARHS"/>
    <dbReference type="OrthoDB" id="10050244at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000151">
        <property type="entry name" value="Tryptophan synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000001">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000004">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="14">
        <location>
            <begin position="344"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ44916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="702" mass="76073" checksum="AF014A5BEC84E660" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGZ2</accession>
    <name>C4YGZ2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease III</fullName>
            <ecNumber evidence="3">3.1.26.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_03333</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonuclease III family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="3"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGZ2"/>
    <dbReference type="PaxDb" id="5476-C4YGZ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03333"/>
    <dbReference type="HOGENOM" id="CLU_026251_1_0_1"/>
    <dbReference type="OMA" id="MIIYNKF"/>
    <dbReference type="OrthoDB" id="2392202at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034963">
        <property type="term" value="P:box C/D sno(s)RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030847">
        <property type="term" value="P:termination of RNA polymerase II transcription, exosome-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19876">
        <property type="entry name" value="DSRM_RNT1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000001">
        <property type="entry name" value="Ribonuclease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040540">
        <property type="entry name" value="RNase_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044449">
        <property type="entry name" value="Rnt1/Pac1_DSRM_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF0">
        <property type="entry name" value="RIBONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18497">
        <property type="entry name" value="RNase_3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="11">
        <location>
            <begin position="242"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="10">
        <location>
            <begin position="397"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="33"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="503"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ45024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="611" mass="68811" checksum="9A532DCFE9156BF9" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHF3</accession>
    <name>C4YHF3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_03499</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHF3"/>
    <dbReference type="SMR" id="C4YHF3"/>
    <dbReference type="PaxDb" id="5476-C4YHF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03499"/>
    <dbReference type="HOGENOM" id="CLU_011226_14_0_1"/>
    <dbReference type="OMA" id="SFYQAIF"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd10291">
        <property type="entry name" value="GST_C_YfcG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000172">
        <property type="entry name" value="Glutathione S-transferase GstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000114">
        <property type="entry name" value="Glutathione S-transferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="95"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ45185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="25261" checksum="6BE2DD40753181C1" modified="2010-10-05" version="1">MTKPIQFYTYGTPNGFKVSIFLEVLGLAYETISVDITKNESKSDWFVKLNPNGRIPTIVDPNFKDGEITISQTGAILQYLADNYDKEHKYSYAFGTEEYYKTLEYLIFQVSENGPIQGQLNHFKLFAKEKIEYGITRYENDTKRIYGVYEDILKRNSANDSKYLVGDRYTVADYALFGWAYSLHKVGIDIHDWPLLGKWFDALNKDPAVIKGVNVPEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHG1</accession>
    <name>C4YHG1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_03507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHG1"/>
    <dbReference type="PaxDb" id="5476-C4YHG1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03507"/>
    <dbReference type="HOGENOM" id="CLU_2222930_0_0_1"/>
    <dbReference type="OMA" id="CNDRFRI"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ45193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="106" mass="12461" checksum="56D38E79B1C4CF94" modified="2009-07-28" version="1">MLLSSSIYFEFFLSKSTDEIQTELSMPIFTNNYYSDGYIESKKKRLASKGCNDRFRIFGGGTHQCDLNRDTPRTIHPFTTNTQNAILVRRQKKNKKKKREELINFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHR8</accession>
    <name>C4YHR8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_03617</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involved in DNA repair.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHR8"/>
    <dbReference type="SMR" id="C4YHR8"/>
    <dbReference type="PaxDb" id="5476-C4YHR8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03617"/>
    <dbReference type="HOGENOM" id="CLU_043978_3_0_1"/>
    <dbReference type="OMA" id="EMKLINM"/>
    <dbReference type="OrthoDB" id="534348at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000006">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.150.10">
        <property type="entry name" value="DNA Polymerase III, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00293">
        <property type="entry name" value="PCNA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="10">
        <location>
            <begin position="128"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ45300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="259" mass="29034" checksum="C214466A0382A0D2" modified="2010-10-05" version="1">MLEGKFEEAALLKKVVEAIKDCVKKCNFNCSEHGITVQAVDDSRVLLVSLLIGQTSFSEYRCDRDVTLGIDLESFSKIIKSANNEDFLTLLAEDSPDQIMAILEEKQKEKISEYSLKLMDIDSEFLQIDDMEYDAVVNMPSSDFAKLVRDLKNLSESLRVVVTKDSVKFTSEGDSGSGSVILKPYTNLKNERESVTISLDDPVDLTFGLKYLNDIVKAATLSDVITIKLADKTPALFEFKMQSGGYLRFYLAPKFDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI15</accession>
    <name>C4YI15_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_03722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI15"/>
    <dbReference type="PaxDb" id="5476-C4YI15"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03722"/>
    <dbReference type="HOGENOM" id="CLU_1825037_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ45397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="141" mass="16390" checksum="D7B4D7773FC80078" modified="2009-07-28" version="1">MEINDEVRNYQNKFVTTIFKTSQEYEVNLSKTQEYSFPVTSLKYNYESTSTQSQVIPFSQPIIETDLPDINEPEEYIPVITVEEFQKHGFAALAKMEKLIKYASENYTDEKLLSVSNFFRDVDSNATKKLPNAPKTAKQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI80</accession>
    <name>C4YI80_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein kinase SCH9</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_04152</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI80"/>
    <dbReference type="PaxDb" id="5476-C4YI80"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04152"/>
    <dbReference type="HOGENOM" id="CLU_000288_52_2_1"/>
    <dbReference type="OMA" id="SYAMGTT"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000116">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="179"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="389"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="15">
        <location>
            <begin position="651"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="129"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="235"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEQ45815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="784" mass="88362" checksum="CF8CD6BB0A8F40E0" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI88</accession>
    <name>C4YI88_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein phosphatases PP1 regulatory subunit SDS22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SDS22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI88"/>
    <dbReference type="PaxDb" id="5476-C4YI88"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04160"/>
    <dbReference type="HOGENOM" id="CLU_044236_0_0_1"/>
    <dbReference type="OMA" id="EVWASYN"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000055">
        <property type="entry name" value="Protein phosphatase 1 regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000446">
        <property type="entry name" value="Protein phosphatase 1 regulatory subunit SDS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ45823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="374" mass="43061" checksum="A29B4FEF8BEDFE33" modified="2009-07-28" version="1">MPIQETNKELVEKPVGILQEEEKEEPILSHTEDEDDDDDDDEDEDDKNQQGNSAVQYPGTVLPDNHPQEIEADQDLTTGYDLDTDYIDLVHLKISSLEDLHLERFKKLESLCLRQNLITSMVGVKDLPDTLEELDLYDNRINHISSSIKHLVHLTNLDLSFNRIKNIKNIETLVELENLYFVQNKIREIKNLDTLTKVTNLELGGNKIEVIENLDKLVNIKQLWLGKNRIYKLQNMDNLVNLRVLSIQSNRITKIEGLENLKNLEELYLSHNGISEIKNLENNINLQVLDVTANKISNLKGLSHLVKLTDFWCSYNQVSSFEEIGKELGKLPDLECVYFEGNPVQLQNPSAYRRKMKLYLGPSLNKIDATYVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIJ5</accession>
    <name>C4YIJ5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thymidylate synthase</fullName>
            <ecNumber evidence="4">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_04271</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="4"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIJ5"/>
    <dbReference type="SMR" id="C4YIJ5"/>
    <dbReference type="PaxDb" id="5476-C4YIJ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04271"/>
    <dbReference type="HOGENOM" id="CLU_021669_0_2_1"/>
    <dbReference type="OMA" id="AYGRFWR"/>
    <dbReference type="OrthoDB" id="766at2759"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.572.10:FF:000005">
        <property type="entry name" value="Thymidylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002497">
        <property type="entry name" value="PRK01827.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548:SF2">
        <property type="entry name" value="THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="THYMIDYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate synthase/dCMP hydroxymethylase" evidence="11">
        <location>
            <begin position="10"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ45930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="315" mass="35996" checksum="343F0E6D41FCD494" modified="2009-07-28" version="1">MTVSPNTAEQAYLDLCKRIIDEGEHRPDRTGTGTKSLFAPPQLRFDLSNDTFPLLTTKKVFSKGIIHELLWFVAGSTDAKILSEKGVKIWEGNGSREFLDKLGLTHRREGDLGPVYGFQWRHFGAEYKDCDSDYTGQGFDQLQDVIKKLKTNPYDRRIIMSAWNPPDFAKMALPPCHVFCQFYVNFPTSSPDPNNPKQAKTAKPKLSCLLYQRSCDMGLGVPFNIASYALLTKMIAHVVDMDCGEFIHTLGDAHVYLDHIDALKEQFERIPKQFPKLVIKEERKNEIKSIDDFKFEDFEIVGYEPYPPIKMKMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIK9</accession>
    <name>C4YIK9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1746 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_04285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIK9"/>
    <dbReference type="PaxDb" id="5476-C4YIK9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04285"/>
    <dbReference type="HOGENOM" id="CLU_074141_0_0_1"/>
    <dbReference type="OMA" id="FIQLVFH"/>
    <dbReference type="OrthoDB" id="5428737at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038967">
        <property type="entry name" value="Dsc4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013715">
        <property type="entry name" value="DUF1746"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39405">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39405:SF1">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08508">
        <property type="entry name" value="DUF1746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1746" evidence="3">
        <location>
            <begin position="59"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ45944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="286" mass="32224" checksum="134B17674B260BD4" modified="2009-07-28" version="1">MSSSSTNNTNNNNTSALNLQAELLEFQNSKYPTIQETITNNASILYKRKKFFLIELRESIQFLECFLIVLIYLRDLSFLKLLIRLTIHLSIININPPLSFKLQLQLSDDYKKSLVKISLRGLIIGNLFCLLTHLIFGIYRESPSGDGYLHGGITIQFIGDRLPYSRFELIILDLLVFFIQLVFHSLIGVIDDSEVLQVTPIQHGNGNNDASMVEEQLDGTFGLDRVHIEEDGYNGNVYLLTIDILGNIKKVFDYQINLQPPSGGRSDSEANQTQMPGAFPGASFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIU4</accession>
    <name>C4YIU4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_04373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ46029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIU4"/>
    <dbReference type="SMR" id="C4YIU4"/>
    <dbReference type="PaxDb" id="5476-C4YIU4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04373"/>
    <dbReference type="HOGENOM" id="CLU_122989_1_0_1"/>
    <dbReference type="OMA" id="GHVQKFT"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019711">
        <property type="entry name" value="ATP_synth_F0_suH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10775">
        <property type="entry name" value="ATP_sub_h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="108" mass="12002" checksum="E84D137FAEEB9073" modified="2009-07-28" version="1">MFRPVARLSSRRLFSVTPRRSNLIGDLYIQHIKAFKPKALTQADIDSAVKAFQLPAKPSVPQADVNAEAVKEYEASDVETASPSTVAAEQTKPDEDWFVFEEVEEAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIW5</accession>
    <name>C4YIW5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell wall mannoprotein PIR1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_04394</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PIR protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ46050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIW5"/>
    <dbReference type="PaxDb" id="5476-C4YIW5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04394"/>
    <dbReference type="HOGENOM" id="CLU_061202_1_0_1"/>
    <dbReference type="OMA" id="REKCDED"/>
    <dbReference type="OrthoDB" id="5415592at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054508">
        <property type="entry name" value="PIR1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051153">
        <property type="entry name" value="Yeast_CWMannoprotein_PIR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254:SF1">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22799">
        <property type="entry name" value="PIR1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946685" description="Cell wall mannoprotein PIR1-like C-terminal domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall mannoprotein PIR1-like C-terminal" evidence="7">
        <location>
            <begin position="153"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ46050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="251" mass="28784" checksum="91C0AB73CB3185D1" modified="2009-07-28" version="1">MKFSTVALSLPLIAMVQAGISSPTYYKPEHTEEIGVETVDYEFALGVREKCDEDTIYLVYEVDDGQLERNDKKVDCNCKSESVAYPTPRPSKTYWDGGDDNDECDEDCDDEDKKKGHKQYKRGEVEEPCETSDCDFCTIEKSFCQDQFTLCEGVLKDQRSAIGSIVANHQFQFDNPIQKDALHTCGWSIVEKDCVKLLALDGCTDFWECPVDDCDTYKLYDSSIDDKCKEIEIIVILFEEEEEEKKKHKSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIW7</accession>
    <name>C4YIW7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_04396</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ46052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIW7"/>
    <dbReference type="PaxDb" id="5476-C4YIW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04396"/>
    <dbReference type="HOGENOM" id="CLU_000288_81_3_1"/>
    <dbReference type="OMA" id="HHCGIIH"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:002659">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000275">
        <property type="entry name" value="SRSF protein kinase 2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="220"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="157"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="419"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="608"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="9"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="76"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="429"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="625"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ46052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="980" mass="111648" checksum="86C42371DE223177" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ75</accession>
    <name>C4YJ75_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CCR4-Not complex component Not N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_03888</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ75"/>
    <dbReference type="PaxDb" id="5476-C4YJ75"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03888"/>
    <dbReference type="HOGENOM" id="CLU_020483_0_0_1"/>
    <dbReference type="OMA" id="VPPGIQD"/>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
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        <property type="entry name" value="Not_N"/>
    </dbReference>
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        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
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            <begin position="24"/>
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        </location>
    </feature>
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            <begin position="188"/>
            <end position="294"/>
        </location>
    </feature>
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            <end position="378"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ45559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="652" mass="73828" checksum="B6AB97D4C016EAB7" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJD0</accession>
    <name>C4YJD0_CANAW</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CAWG_03943</name>
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    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
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                <person name="Cuomo C.A."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="3358869at2759"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="53"/>
        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="106" mass="11559" checksum="D6A78B6D344B4753" modified="2010-10-05" version="1">MSSSNTPNKQAISSNERQSIIRTTLTPPSSTTSGNHPDPSLSSSSATQRKLSHLNSQMAQLNANLCDFNDLLVTTCSQYQSIEKLGKIHASIFMAGHTVFEDENFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJI7</accession>
    <name>C4YJI7_CANAW</name>
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        <recommendedName>
            <fullName evidence="2">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
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                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
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                <person name="Shah P."/>
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                <person name="Berriman M."/>
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                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YJI7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04002"/>
    <dbReference type="HOGENOM" id="CLU_040577_1_0_1"/>
    <dbReference type="OMA" id="WRQIYKG"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
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        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:endocytosis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
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        <property type="entry name" value="CLATHRIN INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="2">
        <location>
            <begin position="52"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
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        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ45671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="392" mass="41313" checksum="7C728381E30A21BA" modified="2009-07-28" version="1">MDLLKDAAKNLNLYEVKAYVRKAQNVAMNLTEMESKVREATNNEPWGAPSTANISLIQMLKSFHYIDSKGRDQGINVRNKSKNLIAFLNDDNLIRSERKKARANAKKFGGVSSAAYGGASSMGTGFGSGGSTFTGDDEDFANRVYGDGGVYGERFDDPASAYNNGATGNDNFEEYDVQASSSQATSKPTTSSSRINAKASKKEPQNDLLGDLLSFDGDGQQTSTNTATASRGTGANDDDDDDDFDDFQAAPSQPQKPANLSNNLNNLYNPSSQQQNQAVSGPNYNVNYQASQSTGPAKTTSNNDAFSSLFSSAKTKSKTSTGNTSTSSSTTTPAAAAASVNASNPTSSANDDFFGGFSSNNNSSSNNTKTKPATNGNGTNNTNSGDIDLLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJL3</accession>
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        <recommendedName>
            <fullName evidence="2">Succinate dehydrogenase assembly factor 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_04030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDHAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJL3"/>
    <dbReference type="PaxDb" id="5476-C4YJL3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04030"/>
    <dbReference type="HOGENOM" id="CLU_101052_1_0_1"/>
    <dbReference type="OMA" id="GGDWSYN"/>
    <dbReference type="OrthoDB" id="201362at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012875">
        <property type="entry name" value="SDHF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524:SF3">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07896">
        <property type="entry name" value="DUF1674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ45697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="139" mass="15582" checksum="871444BFDE9D682C" modified="2009-07-28" version="1">MSTMLARIFKQPSTLCPLRVGTSSIRFFSPPSKFDFQPGPPRLPKEQQEEFEKLQSIANSQIAIEEYNDQIAQQQAEGSTQEPKAPIVNSEIGSFSSLKLVPDFEGDVNPKTGERGGPKQEPLKHTKDEWSFNGRVIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJM4</accession>
    <name>C4YJM4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_04042</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJM4"/>
    <dbReference type="SMR" id="C4YJM4"/>
    <dbReference type="PaxDb" id="5476-C4YJM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04042"/>
    <dbReference type="HOGENOM" id="CLU_092544_0_0_1"/>
    <dbReference type="OMA" id="IMKTGNY"/>
    <dbReference type="OrthoDB" id="9973266at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032265">
        <property type="term" value="P:XMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000033">
        <property type="entry name" value="Xanthine phosphoribosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363:SF1">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ45708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="213" mass="24248" checksum="FC1A6FE1EAACB70C" modified="2009-07-28" version="1">MSESEKMYISYNNIHQLCQEIAPKIKEFKPDLIIAIGGGGFIPARMLRSFLKEPGQPNVRIMAIILSLYEEIESENGIEKPGTQVVRTQWIDYHQSKIDLVGKNVLIIDEVDDTRTTLHYAVSELKKDVEEQSKAKGADPKDTKFGIFVLHDKQKQKKAELPDDIMNTGNYFAARSVPDSWIAYPWESTDIVYHQMKAEEQGNDVFLPSSTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJM5</accession>
    <name>C4YJM5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJM5"/>
    <dbReference type="PaxDb" id="5476-C4YJM5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04043"/>
    <dbReference type="HOGENOM" id="CLU_633123_0_0_1"/>
    <dbReference type="OMA" id="MATTIMM"/>
    <dbReference type="OrthoDB" id="4012758at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="438" mass="49340" checksum="B277D6146CCEF70A" modified="2009-07-28" version="1">MSQTKLKRTFKEPSTTVSVTSTNVSNKIDPDNEVANNSSSSTQAKRNGLSDSVHSTPHKRVPKLEDTTSKKVFAELSNKTVEKKSENESSSSSSINKSDTSKKREESKASSEILTKPKHHFRRAENKNPDNGGRNKDKENLSSLSSNSNSLPQQLFKIQATVPQTTAIVVDPGNDTVPSNIPSDKEAIDAAKSEKETNKYEHQSIDATSNEQAVSLSEDSFPMATTIMMSSLPRKRKWPSSLKSLFCINSIVESNKLEYEESGVCDLQKLPEISTQYRLKEINGFGVLSTTQSLTPANQQIYQKLVATGLELSLEFCRYLEILNERSMKQDIKDSFSIQFGRIHSGLPFTTNHTNSDATKEELLHIGELFDEVFNNNNTVWIASKFEYNSFGRKFRKAIVETLESDYQIRISHRRDLFPRQMIAASLFQWKKNIHLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJW1</accession>
    <name>C4YJW1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_04131</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJW1"/>
    <dbReference type="PaxDb" id="5476-C4YJW1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04131"/>
    <dbReference type="HOGENOM" id="CLU_013253_4_0_1"/>
    <dbReference type="OMA" id="NQSIVWA"/>
    <dbReference type="OrthoDB" id="5839471at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000231">
        <property type="entry name" value="Sap98p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000188">
        <property type="entry name" value="Sap99p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF75">
        <property type="entry name" value="ENDOPEPTIDASE (CTSD), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944267" description="Peptidase A1 domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="58"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ45795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="364" mass="39640" checksum="6B8CF91E3EEF106E" modified="2010-10-05" version="1">MIFNILSFISLAIFVDAVALKSNPKVISFDFELRFSDPIKRDTNFGTGTAAPVKDTHWSFPLKIGSNQDPVTLAADTGSWLIQINDANATCPNCHKHGTYNSSGSSTVVKSGKTARSFFTRSAYYIGELVSDSIQIGNLQIPQVTFNDVYNSTAGDGIFGLARPPSDKNQSIVWAAKYHGLVDKAAYSIYLQNLDGTPGALTVGGYDAAKVDGDITWTSIRNANVQAHLGHIEINGEIIDVNKNYTIDTGGRYGFLPEAAYNQVIANLPEDPKFGADRGQITCSLLEGKNFTYNLNGVDYTFPLRTLYVPTENTDHCYLALLKGNAAQLGAYVFRNLFVAVDFEDDLIGLASLKNTTATNIRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK23</accession>
    <name>C4YK23_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Proteasome assembly chaperone 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_05818</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the PSMG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK23"/>
    <dbReference type="PaxDb" id="5476-C4YK23"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05818"/>
    <dbReference type="HOGENOM" id="CLU_062640_2_1_1"/>
    <dbReference type="OrthoDB" id="10260712at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="entry name" value="PAC-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016562">
        <property type="entry name" value="Proteasome_assmbl_chp_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010044">
        <property type="entry name" value="UCP010044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ47252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="220" mass="24879" checksum="C884A36A900402F6" modified="2009-07-28" version="1">MKSSSGTSLRKVFNPDLKHSTLIIPSVSIGNVPQLAIDLLIHTHNLEKVDSLDDLYLYPFASPVDYVTEPKKGISHAAEVFHNKDLNLTLIQQRSPILPYNTKLYVTNIIIPFITSHEFDRILILDSSDAGLVEHISSGGIELYTKEDLLSESLESMKLNKEESTTAAHEDNRNSKYVRCLLENFNLSNDSNESHSNEFKDVVIDLLVSYVYEGDNDLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKB4</accession>
    <name>C4YKB4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_05911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKB4"/>
    <dbReference type="PaxDb" id="5476-C4YKB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05911"/>
    <dbReference type="HOGENOM" id="CLU_056292_1_0_1"/>
    <dbReference type="OMA" id="IIPDREH"/>
    <dbReference type="OrthoDB" id="421671at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025638">
        <property type="entry name" value="DUF4336"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835">
        <property type="entry name" value="YALI0C07656P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ47343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="278" mass="31631" checksum="24D370D0388427C9" modified="2009-07-28" version="1">MGYPPNFKIVTKSLTENILLASTAFSRVDKFNFGARMAVFKFPQSNKIILWSPLPYTPQVIDVLTKFTNNTNESNLNIAYVIIPDREHNLAAKSYKEKFPGCKLIGMEGLDENSLKLDYKFIKSMGNKVLKNDDLRQIFNDNDSGLIVDNFEFVYLPNHANQELVVFDKSSSTLFEADLLFNLGVPGSTSGETILEQYSPELGFPKGFNPHSGWSFITRYLQPYSKVGRFLFRKLVDINHSKPGLEAIYNSWDFKTIVMCHGNIITKDAKEAFKHVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKD7</accession>
    <name>C4YKD7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKD7"/>
    <dbReference type="PaxDb" id="5476-C4YKD7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05939"/>
    <dbReference type="HOGENOM" id="CLU_012624_0_0_1"/>
    <dbReference type="OMA" id="VFCIDSE"/>
    <dbReference type="OrthoDB" id="2285229at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:mRNA catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="NA-bd_OB-fold"/>
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        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="2">
        <location>
            <begin position="642"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ47366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1149" mass="131848" checksum="01A7FD3BA1EDD8C6" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKM0</accession>
    <name>C4YKM0_CANAW</name>
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        <recommendedName>
            <fullName evidence="3">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_06026</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06026"/>
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    <dbReference type="OMA" id="VISYAEW"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand-dom_pair"/>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
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    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
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    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001751">
        <property type="entry name" value="S100/CaBP7/8-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00303">
        <property type="entry name" value="S100_CABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="78"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="146"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="296"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="383"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="481"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ47449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="571" mass="63477" checksum="08404F7F0A098279" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKN7</accession>
    <name>C4YKN7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Yea4p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_06043</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKN7"/>
    <dbReference type="PaxDb" id="5476-C4YKN7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06043"/>
    <dbReference type="HOGENOM" id="CLU_033007_1_1_1"/>
    <dbReference type="OMA" id="NPFTGWH"/>
    <dbReference type="OrthoDB" id="999962at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005462">
        <property type="term" value="F:UDP-N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005464">
        <property type="term" value="F:UDP-xylose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF4">
        <property type="entry name" value="NUCLEOTIDE SUGAR TRANSPORTER SLC35B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ47466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="36445" checksum="8806C80C1DA9054C" modified="2009-07-28" version="1">MRSLTYISISGWLNILLQVFGGCCSNVFVLEDLLYNNKSEYSLGTLVTFSQFLITSILSIPISTKGFIRPTVPVSRWIFPVVLYFLTSLLNNLVWQFDITVPMHIIFRSSGTVVTMLVGYFFGNKRYSKHQIVSSIFMTLGTIMATLPEGNSLSIEINIKFLTGILILTIASVISAFMGLYSELIYKQYGNQWHESLFYNHFLALPLFVFVSPTIYREFGVVLQSKQVTLGAFKFPRQLLSLTVNVLTQFICTKGVNMLAGETSALTVTVVLLVRKFVSLILSVIFYGNTMSTSGMIGSIIVFGSAAYYSISGISDRKIIEVKKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKU6</accession>
    <name>C4YKU6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tetrapyrrole biosynthesis uroporphyrinogen III synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_06105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKU6"/>
    <dbReference type="SMR" id="C4YKU6"/>
    <dbReference type="PaxDb" id="5476-C4YKU6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06105"/>
    <dbReference type="HOGENOM" id="CLU_051874_0_1_1"/>
    <dbReference type="OMA" id="IHGADTG"/>
    <dbReference type="OrthoDB" id="5595751at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10090:FF:000010">
        <property type="entry name" value="Uroporphyrinogen-III synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390">
        <property type="entry name" value="UROPORPHYRINOGEN III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390:SF0">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="271" mass="31097" checksum="6135DDB0C0F197BB" modified="2009-07-28" version="1">MTNVILLKNASIPSDPYDIKFSNSNKYKPNFVPLLTHCHKDKSQTLSFLISDEFLNNIPIFIITSQRAVEMFKECIEELNHDIRQRIYQKIGYTVGPATYKILKSVGFKDVRGGDEAGNGSKLADLIKQDTIGRENIPMVFFTGVIRKDIIPRKLIDSGYNNFQEFILYQTGDRLDIIDNFKKVIHSLDKGKDNDDVWIVFFSPQGTKEIVNYLIDRDGDSNQKNWKIASIGPTTRDYLKDFDLSPHVIAPKPDPEALFETIFQYDKTYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL40</accession>
    <name>C4YL40_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA-capping enzyme subunit beta</fullName>
            <ecNumber evidence="8">3.6.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-triphosphate monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_01555</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the fungal TPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="8"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL40"/>
    <dbReference type="PaxDb" id="5476-C4YL40"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01555"/>
    <dbReference type="HOGENOM" id="CLU_028201_0_0_1"/>
    <dbReference type="OMA" id="DWVYATI"/>
    <dbReference type="OrthoDB" id="272147at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07470">
        <property type="entry name" value="CYTH-like_mRNA_RTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.10:FF:000010">
        <property type="entry name" value="mRNA capping enzyme subunit beta, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040343">
        <property type="entry name" value="Cet1/Ctl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118:SF1">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE CTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="10">
        <location>
            <begin position="261"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ43321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="520" mass="58900" checksum="BC0EB0F3676637F6" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLU0</accession>
    <name>C4YLU0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein FMP42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_01809</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC43A transporter (TC 2.A.1.44) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLU0"/>
    <dbReference type="PaxDb" id="5476-C4YLU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01809"/>
    <dbReference type="HOGENOM" id="CLU_014401_1_1_1"/>
    <dbReference type="OMA" id="CNILQQV"/>
    <dbReference type="OrthoDB" id="330047at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF2">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="512"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ43571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="61227" checksum="85AA8C5D7DC25092" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLV6</accession>
    <name>C4YLV6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Geranylgeranyl transferase type-1 subunit beta</fullName>
            <ecNumber evidence="4">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Geranylgeranyl transferase type I subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_01825</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.59" evidence="4"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLV6"/>
    <dbReference type="PaxDb" id="5476-C4YLV6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01825"/>
    <dbReference type="HOGENOM" id="CLU_028946_2_1_1"/>
    <dbReference type="OMA" id="CHKTFLP"/>
    <dbReference type="OrthoDB" id="24893at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02895">
        <property type="entry name" value="GGTase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000077">
        <property type="entry name" value="Protein geranylgeranyltransferase type I subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041960">
        <property type="entry name" value="GGTase_I_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF4">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-1 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="13">
        <location>
            <begin position="4"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ43587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="390" mass="45756" checksum="E5E5BFC2352301A4" modified="2009-07-28" version="1">MNQLLINKHEKFFNRCLIGLPSTAQSEDSNKLAIIYFCLHGLQLIQKFQFTNQELIYYRNFIINQFMIENNQIISFRSTYYFQKTNQKYDCPNLSSTLFALYNLLILKSPYHTIINRKKIMNFLCKCQVKDGINKGGFVPTLYYNEENGDYKQYGEPDLRVCYMALLIRHLMKYDDNNNNNNNNNNREDSNETDIDLISLQQFILDRININGGFSSTIMDESHLGFTFCAIASLKLLNYPLEKLKSTKEWLIHRQVDYPENLYPKDGNGNGDNYEYYRNIDIGGFNGRENKLSDTCYSWWCTGSLYNIDVNFIKLVDLNKAEDYLLNKTQNQLFGGFGRDPDSTPDPMHSYLALASLSLWNHEKFALQEINPILTITKESYQFFKEKIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMJ5</accession>
    <name>C4YMJ5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phenol 2-monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_02077</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMJ5"/>
    <dbReference type="PaxDb" id="5476-C4YMJ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02077"/>
    <dbReference type="HOGENOM" id="CLU_009665_9_2_1"/>
    <dbReference type="OMA" id="DYWKVFV"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF20">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="203"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="311"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="7">
        <location>
            <begin position="471"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="709" mass="81206" checksum="51E04A026623198F" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMK0</accession>
    <name>C4YMK0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMK0"/>
    <dbReference type="PaxDb" id="5476-C4YMK0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02082"/>
    <dbReference type="HOGENOM" id="CLU_044499_1_0_1"/>
    <dbReference type="OMA" id="IWYGRVF"/>
    <dbReference type="OrthoDB" id="10253744at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF7">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ43831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="302" mass="34841" checksum="41C7D542389BECA6" modified="2009-07-28" version="1">MFRLLARRNYSIHWRFKDVCPSPRYDTGCTYCQPEFPTNLAIDFDKNLNKTGAIPTKHVMVLTNPINQISELPSKTEFIPNSIPSEITKYRTMFQTDDQRVTISVIHFNNNRHQQILDQYNIKPGSSQQLVFLYPSMKIIRFDLSVLDQFVKKYLYSKPTAPVYNPFVQAKPPASNNDLFDSIVVDESNFIEDELDKDLLVICGHAKRDLRCGIIAPKLESEFNQVLVRHNLQDTIYTGQVSHVGGHAYAGNVLYYPKDCQTSKDFIWYGRVFPKDVQGIVESTIINKEIIKDLFRGDIEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMM7</accession>
    <name>C4YMM7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMM7"/>
    <dbReference type="PaxDb" id="5476-C4YMM7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02110"/>
    <dbReference type="HOGENOM" id="CLU_1722109_0_0_1"/>
    <dbReference type="OMA" id="FLPWAWI"/>
    <dbReference type="OrthoDB" id="4092725at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="152" mass="17289" checksum="CFACA5ABAC87F3A8" modified="2009-07-28" version="1">MVYSKSLILPVFISIFLPWAWIGFQNTRSSDIRPTKSIPVSINFEKDSEYFNFPDLVAATQIQIDSELRYIANSSVNVQLVDNLNNPKNHTKYSVDLVLSRDNSLGISSDGLKGYVLYSYDAIHSNDLPYLIVQTILYHLLKFEIPIEGKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMT5</accession>
    <name>C4YMT5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="2 11">2.1.1.220</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_02172</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(58) in tRNA + S-adenosyl-L-methionine = N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10365"/>
            <dbReference type="Rhea" id="RHEA-COMP:10366"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
            <dbReference type="EC" id="2.1.1.220"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer; composed of two copies of TRM6 and two copies of TRM61.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="2 11"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMT5"/>
    <dbReference type="PaxDb" id="5476-C4YMT5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02172"/>
    <dbReference type="HOGENOM" id="CLU_025402_4_0_1"/>
    <dbReference type="OMA" id="RPDHRMI"/>
    <dbReference type="OrthoDB" id="1925287at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.20:FF:000002">
        <property type="entry name" value="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="14">
        <location>
            <begin position="64"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="271"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR017269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ43916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="335" mass="38079" checksum="4450D15A196D5E59" modified="2009-07-28" version="1">MSFFQYKNYIEEGDLVLAYISRSTIKPINVKKGEIFNTRYGHFEHDKMIGMKYGEQMPGAKGYGFIHLLHPTPELWTLSLPHRTQIVYSPDSSYIIQRLNVKPGSRVIEAGTGSASFTHSFARTVTLSGKVFTYEFHEPRYLEAKKELEEHKLDNTTITHRDVCNDGFSIDNEFIEGDVVFLDLPSPWDAIPHLDSVISTSKAAGICCFSPCIEQVDRTVRALEENGWTEIEMVEVAAKRWSARKEMVRSVADAVQRIREIQNGRKTGLEVMKKGPSEEPPAKLQKTDNGYKTPKKSTKVKEGDENYTWLNATKSESEIKSHTSYLTFACKIPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMU8</accession>
    <name>C4YMU8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="14">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_02185</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="14"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMU8"/>
    <dbReference type="SMR" id="C4YMU8"/>
    <dbReference type="PaxDb" id="5476-C4YMU8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02185"/>
    <dbReference type="HOGENOM" id="CLU_003827_9_0_1"/>
    <dbReference type="OMA" id="CLDPENW"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
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        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF143">
        <property type="entry name" value="PLASMA MEMBRANE-ASSOCIATED COENZYME Q6 REDUCTASE PGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="62"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ43929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="285" mass="32555" checksum="8D8CBB0A6D79C72D" modified="2010-10-05" version="1">MEDKRELLKQPIHGIYIPIGLILFGTWIFGWEYMPYSIGFIVVIVSIQYYGALKRASSMHQVKWQEFELLDKTLIAPMTSIYRFKLRREDEVLDIPTGHSLACCFNVDGKDEVRFYTPISNQFDKGFFDILVKHYEHGVVTKKLANLQVGQTVQFRGPFGKLQYVPNSAKELALVAGGTGITPMLQVITAIITNLEDDTKIKLLFANNTERDILLKDELDNMAQKYPGLEIKYVTGKFVDKKSFEFLPSPTSDSKIFICGPPAFVEYINEMTKDAGFEKDQVFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN29</accession>
    <name>C4YN29_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PSP proline-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="SMR" id="C4YN29"/>
    <dbReference type="PaxDb" id="5476-C4YN29"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02269"/>
    <dbReference type="HOGENOM" id="CLU_014435_2_0_1"/>
    <dbReference type="OMA" id="IEWFDCD"/>
    <dbReference type="OrthoDB" id="10260794at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007180">
        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052584">
        <property type="entry name" value="U2_snRNP_Complex_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785">
        <property type="entry name" value="SPLICING FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04037">
        <property type="entry name" value="DUF382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="2">
        <location>
            <begin position="270"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="471" mass="54090" checksum="76BB487EEACFE189" modified="2010-10-05" version="1">MAPKRSKNQLRREKLKQRKLEKQAEEPDKSVNVEEPKTGPNSTTISIQIDDDPLYEQFQSVLNKFNNPQEIEITKQESTEDSKDLVYQNGDSSENESDDEDSSDENDEETQKQQQQLSKRQLRIQNKIPLAKLKSSVKSPQVVEWYDVDSKDPYLLIAMKSQPNIIPVPSHWSSKRNYLSSRRGIEKLPYQLPKYIQATGISEMRSGGRDHRTLRQQQREKVQPKMGKLDMDYEKLYQAFSKFQIKPRVFPYGELFEEGKHSNDELVTKAAKIKPGIISLEMRSALSMPQNDGTIPPAWVTIMRDIGKPPSYKDLVIPGLDIKYSNAGYKDRNSDSRREKLKHWGALNTAIESSDGEDDEEDDDGQDEESSVATDSIEVNTTFYPLEEDEVSEEPSLNDILAGLSSANDKPKEEKKLYKIIEERKVTDDDSLTGYTYDLKNDSVEEYSENEDSKNSEDTKNSEEEPEDFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN35</accession>
    <name>C4YN35_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_02275</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN35"/>
    <dbReference type="PaxDb" id="5476-C4YN35"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02275"/>
    <dbReference type="HOGENOM" id="CLU_000422_11_6_1"/>
    <dbReference type="OMA" id="QAMAYGV"/>
    <dbReference type="OrthoDB" id="10249365at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02773">
        <property type="entry name" value="MopB_Res-Cmplx1_Nad11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.740:FF:000016">
        <property type="entry name" value="NADH dehydrogenase (Quinone), G subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.740:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.210:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054351">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015405">
        <property type="entry name" value="NDUFS1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050123">
        <property type="entry name" value="Prok_molybdopt-oxidoreductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF13">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105">
        <property type="entry name" value="RESPIRATORY NITRATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13510">
        <property type="entry name" value="Fer2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22151">
        <property type="entry name" value="Fer4_NDSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22117">
        <property type="entry name" value="Fer4_Nqo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09326">
        <property type="entry name" value="NADH_dhqG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53706">
        <property type="entry name" value="Formate dehydrogenase/DMSO reductase, domains 1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="15" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="12">
        <location>
            <begin position="24"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="14">
        <location>
            <begin position="102"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="13">
        <location>
            <begin position="241"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ44016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="720" mass="79169" checksum="EDF8AE767ECC942A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNL4</accession>
    <name>C4YNL4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_01476</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNL4"/>
    <dbReference type="PaxDb" id="5476-C4YNL4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01476"/>
    <dbReference type="HOGENOM" id="CLU_008850_2_0_1"/>
    <dbReference type="OMA" id="CKYDCYK"/>
    <dbReference type="OrthoDB" id="329563at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="655"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="689"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="723"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="791"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="825"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="406"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="368"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="459"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="511"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ43247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="872" mass="98956" checksum="A08AD6A876BADCA2" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPB5</accession>
    <name>C4YPB5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_03067</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPB5"/>
    <dbReference type="PaxDb" id="5476-C4YPB5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03067"/>
    <dbReference type="HOGENOM" id="CLU_663915_0_0_1"/>
    <dbReference type="OrthoDB" id="6260732at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="97"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ44774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="414" mass="47108" checksum="197133F7E519281A" modified="2009-07-28" version="1">MIARQSNTTEKKGIHVLFSNFETKLIIFYTLFFLSTSNSSRHKQLTMHDINFNILKDRAMDVDPDIRFMALEDLRKFLQDESAASTRTTLNQSLENFFPILLNMLNDQNPDVQTQAIKSFEPMVKYLSNETFSKLVKKLFALVQQNSSSTGNVTGLKSFTVSVPNIALRSLFAQSNSRDKSEFVSDKLSNSNYRFDPHLARYIMDYLIPQIVGNPVTIDSIELLIDLVTEIGYVLTQDELLNLSLYLTKVALTETGLIGKKSMVALERVVALVRTEVVIDKLLAQINQSIEPTKLFVIFQLYSVCLKRGIKPNSIDTIYNTITSNLNIEAAEEEDDDDLDFDNLVKENSLKDEALTTLIDLVSQHFLPVESKNTVIALIKSYVNYNPLAQDEDFIDDEEDDITFRDDEQEDDAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPC3</accession>
    <name>C4YPC3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_03076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPC3"/>
    <dbReference type="ESTHER" id="canal-q5adx4">
        <property type="family name" value="FSH1"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YPC3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03076"/>
    <dbReference type="HOGENOM" id="CLU_051938_2_3_1"/>
    <dbReference type="OMA" id="FEHPGGH"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000779">
        <property type="entry name" value="Serine hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF9">
        <property type="entry name" value="FAMILY OF SERINE HYDROLASES 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="259" mass="29559" checksum="F75F36A587B82394" modified="2009-07-28" version="1">MSKKILCLPGYLQNGSTFAAKSSGIRKILTKKLDCQLDYVDPYHSIESWREFSFPIAANEEESDKTWASIVEKGNNVRWFEHKAPGVNLGLDESVNYLVDYIKQNGPYDGIIGFSQGAAMAEIMTNTIRKLLPSHPDFKISLFISGFFLTEPISDDHSEENRQRINDITDLEEYKSQVQISPDMAKYFTPPQDLNTQVLMVYGDDDNIVAPVRSKYASTFYKSVHMFPHEGAHYVPNKKDFLEPIVKLFDKTLNEKPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPG3</accession>
    <name>C4YPG3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidant-induced cell-cycle arrest protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_02362</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OCA5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPG3"/>
    <dbReference type="PaxDb" id="5476-C4YPG3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02362"/>
    <dbReference type="HOGENOM" id="CLU_547452_0_0_1"/>
    <dbReference type="OMA" id="KYENEFH"/>
    <dbReference type="OrthoDB" id="4085843at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="250"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="385"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ44102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="498" mass="57714" checksum="9C9EA797380EEF2C" modified="2009-07-28" version="1">MSEDSSPPPPLPARKSLDSILIETEISKKLPDLPSAANANQRISFDLNDSVSQISAVRQWEIYTSLQLNETSDIFVNNAIGQNTIRTKLNELKDDHTKFWIDMNDYSSSILLPKRINKLEEEILTGIPSNIRYLVYLKTLLVRQKLNSRETFSSLLTKSRQLRDEYIESLAVDSRVREILIVFNYYVNEITNSKFEIESDENSELMQLPISRFIINVCILLGTFPEASQEDVLYLLLKFNKLYTCLNKDEFFYKVSRSLEEGLADIFKHISVQGINLNSLFRSILVQLFSSELLDEEVCLRVLDFVVFEGFDFVLRSILYLFRKNLEKIQELDGDALLQFLNSPEFCQVEFDFKEVLAEEPSLIQYENEFYLINANSMSNNSNELTNLKEVNDELVVKINDLKRKIDSLQATHSEISDQSEQYTKDLSEAEIENQKLLKRQAELQEKYQNLTMAENLSNTIKANQEFSQRNFELESQIKNLQNSIEEKNAKLAKVQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ50</accession>
    <name>C4YQ50_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Ribonuclease P/MRP protein subunit POP5</fullName>
            <ecNumber evidence="4 10">3.1.26.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_02604</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="4 10"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ50"/>
    <dbReference type="PaxDb" id="5476-C4YQ50"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02604"/>
    <dbReference type="HOGENOM" id="CLU_086710_1_1_1"/>
    <dbReference type="OMA" id="IVRCPRA"/>
    <dbReference type="OrthoDB" id="24745at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030681">
        <property type="term" value="C:multimeric ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3250:FF:000004">
        <property type="entry name" value="Ribonuclease P/MRP protein subunit POP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="entry name" value="Ribonuclease P, Pop5 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016819">
        <property type="entry name" value="RNase_P/MRP_POP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441:SF2">
        <property type="entry name" value="RIBONUCLEASE P_MRP PROTEIN SUBUNIT POP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023803">
        <property type="entry name" value="Ribonuclease_P_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR023803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ44339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="190" mass="21846" checksum="9F39EF0C5FC71AAE" modified="2009-07-28" version="1">MVRIKHRYILFEILYPPTADTRVTPREDFNQFSQSESNALLTLHQSSPNSINVKTILNVIRKSLSDHYGDVGAGKAGMLLNVKYFSNRTSTGILRCGRDQSDYIIGAMSLIEKMENNYVIIRCLHVSGTIKKCEEYSIERTKQLINVIKNKSKGKVDEYISQMNEINHVEEDKEEEQEEKNQDDVRISKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ60</accession>
    <name>C4YQ60_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Methylenetetrahydrofolate reductase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_02614</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ60"/>
    <dbReference type="SMR" id="C4YQ60"/>
    <dbReference type="PaxDb" id="5476-C4YQ60"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02614"/>
    <dbReference type="HOGENOM" id="CLU_025841_2_2_1"/>
    <dbReference type="OMA" id="AWKEEFY"/>
    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000002">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="9">
        <location>
            <begin position="308"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ44349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="614" mass="69929" checksum="83D13A8137D94067" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ73</accession>
    <name>C4YQ73_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ73"/>
    <dbReference type="PaxDb" id="5476-C4YQ73"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02628"/>
    <dbReference type="HOGENOM" id="CLU_660550_0_0_1"/>
    <dbReference type="OMA" id="QNVACLE"/>
    <dbReference type="OrthoDB" id="4017506at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012565010" evidence="2">
        <location>
            <begin position="16"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="416" mass="47096" checksum="57C4A996E6ACD035" modified="2009-07-28" version="1">MKLITLLGLLPFTLARTFHIATNQNVACLEIKAPTTISLTKTIGTASGENPPVLIFNYDEKLLLPIPNFDYLVTDGKIDDYFNEEGFTFAKGFIGSSYNDILIDKLTYDVTTPGTYCIYSPLIDGYEYRVDVEESSIQFDNVVFCIVNIIVNLFYNQFFSRQNKVLFKLIGKFELTKVGIFAVSLLLLLRFNIINYTEDIVSAVDDVFTMVFLMGYGTLYSSYKDQDIGKIVIVTLFTVTPAISSRFFDLKSDVTNLVINNEYYNVVDGVLGSGKFDGLSVVQRIVRDVKAHRFSAVVAALFGVSKLVKFTMYIATIRQTLNKLTPGGTKSGYIYTVVLWLFVYPFASFAFYPDLVYNYYLVTDYGSVLKQFLLESVRDKYIVLMADECHWVLIFLIWFVGNNGLTVEPTSSKKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQD8</accession>
    <name>C4YQD8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQD8"/>
    <dbReference type="PaxDb" id="5476-C4YQD8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02695"/>
    <dbReference type="HOGENOM" id="CLU_1777171_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="146" mass="16078" checksum="5F4ECE3CC44E9302" modified="2009-07-28" version="1">MAINAWSSASFWEKLSILPARSCASLSNSFEIFTSDSLRDSFGIWKSIPRGLPILASSGLGKCGNADNGRYLLVVFVFSCFFLEALFNRRETGFTSDGLGLVFCLSKISFFDVIIGAPVAPRDKHLTKRGVFLIKAWLQSILDSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQK3</accession>
    <name>C4YQK3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_02762</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQK3"/>
    <dbReference type="PaxDb" id="5476-C4YQK3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02762"/>
    <dbReference type="HOGENOM" id="CLU_029881_1_1_1"/>
    <dbReference type="OMA" id="WAPIREP"/>
    <dbReference type="OrthoDB" id="5584247at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052246">
        <property type="entry name" value="Cell_Polariz_PKAAnc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155">
        <property type="entry name" value="A-KINASE ANCHOR PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="36"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ44492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="550" mass="63538" checksum="4907EFEF66031CEB" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQS3</accession>
    <name>C4YQS3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SRR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQS3"/>
    <dbReference type="SMR" id="C4YQS3"/>
    <dbReference type="PaxDb" id="5476-C4YQS3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04420"/>
    <dbReference type="HOGENOM" id="CLU_084828_0_0_1"/>
    <dbReference type="OMA" id="THIRCLA"/>
    <dbReference type="OrthoDB" id="551431at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040044">
        <property type="entry name" value="SRR1L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626:SF3">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="2">
        <location>
            <begin position="19"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="207" mass="23884" checksum="B96FB542A7F740A2" modified="2010-10-05" version="1">MDYGQIIRTSKLFQDISLSLENIEISTIRCLALGSPSESKNARFQLALLIELQQLLDAEVSLYDPIFNEKDNEILKDFTIEKEFTSDSSKTLYFLPHASLELTEEVLNTNQPKYFLANDVIAHTDRLTKKKLADNYPTLSIIVHLLGENKVDDGFTRVSRKRFKEPVITYDIDSVYFDKVQISRYLHTNKNDAWGTSFTDLAYHYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQZ4</accession>
    <name>C4YQZ4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQZ4"/>
    <dbReference type="PaxDb" id="5476-C4YQZ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04491"/>
    <dbReference type="HOGENOM" id="CLU_067848_0_0_1"/>
    <dbReference type="OMA" id="CICINED"/>
    <dbReference type="OrthoDB" id="3998031at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946835" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="30644" checksum="428AD0A3468E08DD" modified="2009-07-28" version="1">MLVLVIALVFLKSILATPPACFLSCINEIAHDCPEDAVNLTCICINEDLIIGCLVDICPFGTFISARDHYIGTCLEHGRPSITNPVPPPAIWPPEPKVSSISNTTMRTEFTSSIMQVTQTVEFPARVTITPIPSDIPKPEIVDESEDEFYNPNEPCEWEETDSLDENGAFIVIRRPVNVPKRYRDPSNVGNIRRVIITRPVNYYSNQQASDNPKPRKVQHVKRIKKFPKKVSKNANESKMSPSTLNQKIKPNRNNLKKLHKKKFKVNRKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQZ7</accession>
    <name>C4YQZ7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_04494</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQZ7"/>
    <dbReference type="PaxDb" id="5476-C4YQZ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04494"/>
    <dbReference type="HOGENOM" id="CLU_076387_2_0_1"/>
    <dbReference type="OMA" id="TYVELRV"/>
    <dbReference type="OrthoDB" id="432645at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.790:FF:000017">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein IMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_bL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="Ribosomal_bL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680:SF9">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ46150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="18378" checksum="C55E804EB71ED523" modified="2009-07-28" version="1">MLILELPTVFEPLPKRRNGEGVMPYLHKQLLEKHDPTGKRRALVENSNTGLRAGDIIKVTYLDRSDVTGRVIGIKRGFLNLGTNILIRTKLNKVGSELRIPVYNPNIRNIEVLHKPTRYMPRTKQYYIREHKRYDVDDVEAFVKKQFGEGRKNKKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR30</accession>
    <name>C4YR30_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04529</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR30"/>
    <dbReference type="PaxDb" id="5476-C4YR30"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04529"/>
    <dbReference type="HOGENOM" id="CLU_1660492_0_0_1"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF112">
        <property type="entry name" value="PROTEIN SNA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ46183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="159" mass="18233" checksum="50496FD53CD0597C" modified="2010-10-05" version="1">MIHNLGGKKLIISIFKFISCSLLKLYLRGYIFFIQFIFDYFLVFYSVVLKQYYNGRSRLVSCVCGIFSYVRVCSRVYTFTILNFLLTSNIVPPVPVLIKRGFFSADFWINILLCLLGFLPGLLHSYYIISVYPYRATYAALGGDGHNNRSDDYGATTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR36</accession>
    <name>C4YR36_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">rRNA-processing protein FYV7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_04535</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the processing of the 20S pre-rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
            <location evidence="1 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FYV7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR36"/>
    <dbReference type="SMR" id="C4YR36"/>
    <dbReference type="PaxDb" id="5476-C4YR36"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04535"/>
    <dbReference type="HOGENOM" id="CLU_105541_0_0_1"/>
    <dbReference type="OMA" id="MGPKIDD"/>
    <dbReference type="OrthoDB" id="2135053at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013730">
        <property type="entry name" value="Fyv7/TAP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017265">
        <property type="entry name" value="Fyv7_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08524">
        <property type="entry name" value="rRNA_processing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037708">
        <property type="entry name" value="rRNA_proc_FYV7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="99"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ46189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="142" mass="16786" checksum="34FC3EC1FA0E5CAE" modified="2009-07-28" version="1">MHPNNKNSFKSKKKFIDRREAKSQDIKRALTHRARLRKNYFKLLEKEGLQEEGKPEDENDIRPTKKKGINFEERAAIVKQRKEEKRKFKLASVQAKLEKIESNSKERALKREQLKKSTTKGQPLMGPRINDLLDKIKKNEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR71</accession>
    <name>C4YR71_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_04570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR71"/>
    <dbReference type="PaxDb" id="5476-C4YR71"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04570"/>
    <dbReference type="HOGENOM" id="CLU_013659_0_0_1"/>
    <dbReference type="OMA" id="TKVACDY"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="119"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="803"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ46224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="922" mass="104087" checksum="A54B8663AFF0A8F3" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRA2</accession>
    <name>C4YRA2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Eukaryotic translation initiation factor 2 subunit gamma</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_04601</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRA2"/>
    <dbReference type="PaxDb" id="5476-C4YRA2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04601"/>
    <dbReference type="HOGENOM" id="CLU_027154_0_0_1"/>
    <dbReference type="OMA" id="NIGMVGH"/>
    <dbReference type="OrthoDB" id="1045173at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000011">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="104"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ46255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="534" mass="58549" checksum="64F77164ECB8D3F6" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRD3</accession>
    <name>C4YRD3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_04632</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRD3"/>
    <dbReference type="PaxDb" id="5476-C4YRD3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04632"/>
    <dbReference type="HOGENOM" id="CLU_029094_0_0_1"/>
    <dbReference type="OMA" id="MMVKEVA"/>
    <dbReference type="OrthoDB" id="2017782at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052645">
        <property type="entry name" value="Pumilio_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093:SF1">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="75"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="304"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ46286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="483" mass="54723" checksum="7A2D0CDF7D797E3A" modified="2009-07-28" version="1" fragment="single">MLDELPELSYDYLGNTIVQKLFTLVESSLVKLMMVKEVAPYLTQLGIHKNGTWAIQKIINLCHSDYQQMYLIGASLKPYAVKLFNDQFGNYVIQGCIKFGSPFNDFVFEAMLDNFLEISVGRFGARCIRTILESCHDSSSTSPVTNEQVLLVAGLIIEFANELAVNSNGSLLITWYLDTFKDCDSKIELLMSKFLPNIRALCVHKLANLTVLKILNNRIDDKSRVATMDAIFNNKETLEYILQESDNSNTTAGPLFIYKILSNPTLADLVNQHIPTIRKILMELNIVNFQNYKKLMDEVGISSTRIGRNGSTKRNGATNGSSRRGGNMRGNKQDGYVTQVPPPPPQQQQQQQQQQYFVQGISNPPASLQQGQHSPIKPQLQQQQQQQQRSGSPPFQNRYIPMPQAPSQYNNVTPQMYMKQMYAQQQAQIQQQFYLQQQQQQQQQQQQQQQMSPQEFAVMQQLEQLSLSSAALGYNSNPGTPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRM4</accession>
    <name>C4YRM4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_04726</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRM4"/>
    <dbReference type="PaxDb" id="5476-C4YRM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04726"/>
    <dbReference type="HOGENOM" id="CLU_079653_1_2_1"/>
    <dbReference type="OMA" id="IDGPFKY"/>
    <dbReference type="OrthoDB" id="292693at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000107">
        <property type="entry name" value="Coenzyme Q-binding protein, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="4">
        <location>
            <begin position="36"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ46377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="181" mass="21037" checksum="36DF1F47D34E0A53" modified="2009-07-28" version="1">MFKRAIVGNVYRIPTRSFFGVSKPQSYEISKILHGSPKQVYDIVSQVDQYKTFVPFVEDSFISQRNKDELPTRAGLLVGWKDIVEKFECDLICVENKEVTAKSLQLDLFDNLETIWKFHEHGGNKCKVDFKLAFKFKSPIYDKLSSLFAPQVSEIMIGAFEKRLKQIKLNESMKKYQKPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRP7</accession>
    <name>C4YRP7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRP7"/>
    <dbReference type="PaxDb" id="5476-C4YRP7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04750"/>
    <dbReference type="HOGENOM" id="CLU_1320721_0_0_1"/>
    <dbReference type="OrthoDB" id="10287849at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="208" mass="23852" checksum="D622BCB339F20313" modified="2009-07-28" version="1">MGPTRYLILQQIPISSLLDPNPVIETTENSESNKEINLLPRDVRYEILHHFNLRDDEITPRDGYSRKNNDYVEINSCTGFHYDPSLDTYITGTSGYSKRMNMGLSHATLNKYGIGGKYSRGRFYDFSKHNNPKSKPEEKTAQEPIRVKMVDLLPSLTDTEEKSFDESNLSHSSTKKRKREDDTSVDIRDNTAIKLPPISTLPMPFPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRX3</accession>
    <name>C4YRX3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Transcription elongation factor SPT4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_04831</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SPT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRX3"/>
    <dbReference type="SMR" id="C4YRX3"/>
    <dbReference type="PaxDb" id="5476-C4YRX3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04831"/>
    <dbReference type="HOGENOM" id="CLU_138052_2_1_1"/>
    <dbReference type="OMA" id="FDGMIAV"/>
    <dbReference type="OrthoDB" id="248751at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.210:FF:000008">
        <property type="entry name" value="Transcription elongation factor SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025023">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0137">Centromere</keyword>
    <keyword evidence="10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="9">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR025023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ46476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="112" mass="12538" checksum="67ABE56CD74BBC9E" modified="2009-07-28" version="1">MSSRSERACMLCGIIQPMKSFIDYGCPNCESLLHYQYNDNKQVQDCTSPSFEGLVALGEDNKGSWVARWLRIDSFTAGLYAVKVNGKLPPSIIAELEEQNVIYRPRDGSAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS35</accession>
    <name>C4YS35_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS35"/>
    <dbReference type="PaxDb" id="5476-C4YS35"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04893"/>
    <dbReference type="HOGENOM" id="CLU_073623_0_0_1"/>
    <dbReference type="OMA" id="PYPQYQR"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd12432">
        <property type="entry name" value="RRM_ACINU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034257">
        <property type="entry name" value="Acinus_RRM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="36231" checksum="F515188C7D5B9038" modified="2009-07-28" version="1">MSDLEYDRDVAMEEPQPYPQYQRPPPPRKIDFIGLDLPDIADPMYKSKPEQDLDVRYEVKEENEFHETRALFIGNLRRPINAAHFQSYLRDLAREEGSFIIERAWLSRARTHAIVLVSSEHGAVYIRSKLLNTVYPPKEEEKRLKLEFEEKEIERFEEQKRLYEQELGRLNEKEREALPPPLEPREYVTERIPLYVEYIPVKAINQWTFEEDRGPRDGKWKLEFEHRDGDTVASHTLLNSDYIPRYVPTRRGPPRRYNDRPYNAPPRRADSYVPNGTNRRTDTYIPSRDRNRSRSPSRSPRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS98</accession>
    <name>C4YS98_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS98"/>
    <dbReference type="PaxDb" id="5476-C4YS98"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04959"/>
    <dbReference type="HOGENOM" id="CLU_062844_0_0_1"/>
    <dbReference type="OMA" id="PMKRNNT"/>
    <dbReference type="OrthoDB" id="10639028at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36911:SF3">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36911">
        <property type="entry name" value="LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="304" mass="33569" checksum="997611D7ABDC8A83" modified="2009-07-28" version="1">MSFYNTNTNYSPSFNQLSPPLPPPQQQQQFSGHSSSPMKRNNTFKSKLKSLKNELHEAMTSTIIATTTTTTTTKPPLSPWSRPPTRSNSTSSYRSPFSSIKLSNGNNTGKSSGFSSCQTSPQSLSLSSTKNDNNNNNNNNGIITDVFQASRSRSISLPISKFKSPTTIIATVTNSSTTTTNTNSPCSISYTSLDYDYDYDNLFEFNSPTSSYDPNFKNEKLTTNTIDDLGKEEKFLLPPLPSSATTLTPKISSPGKLDNNNNNNNNNNNNNNNNNNYNNNNNNNNNDNDDNNNCNNNNNDQVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSH0</accession>
    <name>C4YSH0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1,4-alpha-glucan-branching enzyme</fullName>
            <ecNumber evidence="4">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glycogen-branching enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_05036</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Glycogen-branching enzyme participates in the glycogen biosynthetic process along with glycogenin and glycogen synthase. Generates alpha-1,6-glucosidic branches from alpha-1,4-linked glucose chains, to increase solubility of the glycogen polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="4"/>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSH0"/>
    <dbReference type="PaxDb" id="5476-C4YSH0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05036"/>
    <dbReference type="HOGENOM" id="CLU_011131_2_2_1"/>
    <dbReference type="OMA" id="YEMHLGS"/>
    <dbReference type="OrthoDB" id="196493at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11321">
        <property type="entry name" value="AmyAc_bac_euk_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000001">
        <property type="entry name" value="1,4-alpha-glucan branching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000003">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="12">
        <location>
            <begin position="147"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ46673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="676" mass="77809" checksum="959C2C23BE2440A2" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSH1</accession>
    <name>C4YSH1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSH1"/>
    <dbReference type="PaxDb" id="5476-C4YSH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05037"/>
    <dbReference type="HOGENOM" id="CLU_007739_1_1_1"/>
    <dbReference type="OMA" id="MGWLEGI"/>
    <dbReference type="OrthoDB" id="2117459at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06869">
        <property type="entry name" value="PX_UP2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047168">
        <property type="entry name" value="LEC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024554">
        <property type="entry name" value="LEC1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024555">
        <property type="entry name" value="PX-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12825">
        <property type="entry name" value="DUF3818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12828">
        <property type="entry name" value="PXB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="1">
        <location>
            <begin position="202"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="921" mass="108670" checksum="F2367A54B1D49C7B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSJ6</accession>
    <name>C4YSJ6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_05064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSJ6"/>
    <dbReference type="PaxDb" id="5476-C4YSJ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05064"/>
    <dbReference type="HOGENOM" id="CLU_034208_0_0_1"/>
    <dbReference type="OMA" id="FYPPTNI"/>
    <dbReference type="OrthoDB" id="4095076at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="466" mass="55042" checksum="1A00088A74D45E69" modified="2009-07-28" version="1">MLVKLPLEIQIKLLLMVPNSNLKFVNSHFYLLYNDLYYHKIVNTFGEATVKVIIKILPWLKPYIKSLDVFRKQARLIIAKRLQLEELPIIVHNPDFTTTVNPLNCQYIKDSWKYIYSILKNKRFYAEYCDYKIDEPSNYVFNHYVEINRTYLLSYNKVCWLAPGDYNLNIALAVKNGQGLGTTKFEVRYQELNESGETLIKSQTFYPPSNINEILPKNQFVCLNVGHFVIPPPSETESRFYSKQFQSNSDHNKLRRIEIVMEEIGLYLKSGFRVYFIDISQPSMLFNEYDLLYYSINETDYRYFINILLKNLYKALNYVQNAGCSDDLSYQYNRDVYGDGDPFSIINKYDKQFLLKYEKTNGFLSSSSSSSSLALSSLQDYVLYDNKKLLNYGRFFYLNKFTIRNFKFTTIYQQRQFINRFGDYLVDCKEQDSKKSVVDGDEIPIERNCSYDHYGLKWKLPILGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSS4</accession>
    <name>C4YSS4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_05143</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSS4"/>
    <dbReference type="SMR" id="C4YSS4"/>
    <dbReference type="PaxDb" id="5476-C4YSS4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05143"/>
    <dbReference type="HOGENOM" id="CLU_062853_3_0_1"/>
    <dbReference type="OMA" id="GPRNKMP"/>
    <dbReference type="OrthoDB" id="2449818at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000006">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000002">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000009">
        <property type="entry name" value="Ribosomal protein L10a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ46777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="217" mass="24379" checksum="0F4B5AB4F18320D7" modified="2010-10-05" version="1">MSKITSSGVRENVHKLLEYSTETKKRNFLETVELQVGLKNYDPQRDKRFSGTLKLPQVPRPNMTICIFGDAFDVDRAKSLGVDAMSVDDLKKLNKNKKLIKKLAKKYNAFIASEVLIKQIPRLLGPTLSKAGKFPTPVSHNDDLYSKVTDVKSTIKFQLKKVLCLAVAVGNVDMEEDVLVNQIMMAANFLVSLLKKNWQNVGSLVIKSTMGPSFRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSY7</accession>
    <name>C4YSY7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">nicotinamidase</fullName>
            <ecNumber evidence="6">3.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nicotinamide deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_05683</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.19" evidence="6"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSY7"/>
    <dbReference type="PaxDb" id="5476-C4YSY7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05683"/>
    <dbReference type="HOGENOM" id="CLU_068979_13_0_1"/>
    <dbReference type="OMA" id="HPPNHTS"/>
    <dbReference type="OrthoDB" id="3341310at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019363">
        <property type="term" value="P:pyridine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="8">
        <location>
            <begin position="4"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ47123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="244" mass="27972" checksum="CC376C081F6D868F" modified="2009-07-28" version="1">MKKTALIVVDLQEDFLPPNGSLAIKNGRSVIPKINQLLPSQDNHSKFDWSLIVATQDWHPPNHTSFASQHENVAPFTEIEFIHPEKKLDPKTNQPIVMNQIVWPDHCVHGTKGAQLEPSFANQFEKLTKQDDNNTAPCKIVKKGYLPDREYYSCFQDCWGLHHTELIDLLHEYDIENVVFVGLAYDFCVLRSAIDSAKNGFKTFVLKNYCESVYPEKINDTDKLYIDNGVTIVDNDEKFDSLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT29</accession>
    <name>C4YT29_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_05727</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT29"/>
    <dbReference type="SMR" id="C4YT29"/>
    <dbReference type="PaxDb" id="5476-C4YT29"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05727"/>
    <dbReference type="HOGENOM" id="CLU_098404_1_2_1"/>
    <dbReference type="OMA" id="QQTFKVI"/>
    <dbReference type="OrthoDB" id="369569at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017207">
        <property type="entry name" value="UCP017207_TM-p85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="149"/>
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        <location>
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            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ47165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="176" mass="19702" checksum="AF4FAD9B075275A9" modified="2010-10-05" version="1">MNAYSEILKPRIIPISSSKNDVPPPPGYSESVFSTATKSSTSSGKKTKHDDADLNALKSKKIWELAIGPAKSIPMNLFMSYMTGNSLQVISVTMTLMLLWNPIKAIFNETNPTFSKLSTKNNGSEIILAKIVFIICQVLNMGIGVYKLYKMGLIPHQEADWLAWKEPKKIIDRLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTQ9</accession>
    <name>C4YTQ9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_05554</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000313">
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    <dbReference type="OMA" id="FFEPRSH"/>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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            <end position="335"/>
        </location>
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    </feature>
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        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="344" mass="38568" checksum="2E42419DC135FB46" modified="2009-07-28" version="1">MKLDQLINQAAPQPVPTVTRLSSIGLSSSSSTGVTNSGNAPLLPHNHNHFNYYPKTATTSSVHNQRVNLPPISDILQQAQHYLPPPPQQQQQPQQPSQSVSSYRQAQAQLPPLPLAATANSNSNYKYYDYYQSPNSDHQQRSYTSSSSTVPSPRIPHSDNTVPSYQQPMMVRNNSYPPIQQQQMQTQYHQQPQYLGVGGDSYFRNRTPQPPVINHNHNNGSNSTLSSSSMSSPLSSPYDSQNHINDSSATGTPTNNFMKHASGASATNGGVNNNRKTRNNLPKEITFILLQWLNDHLNHPYPSSFEKNQLMISTGLNQQQLSNWFINARRRKIKLLKQQQRLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTS4</accession>
    <name>C4YTS4_CANAW</name>
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        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
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    </protein>
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    </gene>
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        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ47015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="708" mass="76597" checksum="43D94D2B710A37A1" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>P0CH68</accession>
    <accession>C4YHL7</accession>
    <accession>Q5AF33</accession>
    <name>LIPA_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipoyl synthase, mitochondrial</fullName>
            <ecNumber evidence="1">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lipoate synthase</fullName>
            <shortName evidence="1">LS</shortName>
            <shortName evidence="1">Lip-syn</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Lipoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">LAB5</name>
        <name type="synonym">LIS1</name>
        <name type="ORF">CAWG_03565</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0CH68"/>
    <dbReference type="SMR" id="P0CH68"/>
    <dbReference type="PaxDb" id="5476-P0CH68"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03565"/>
    <dbReference type="HOGENOM" id="CLU_033144_2_0_1"/>
    <dbReference type="OMA" id="PYCDIDF"/>
    <dbReference type="OrthoDB" id="3231at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000036">
        <property type="entry name" value="Lipoyl synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000398257" description="Lipoyl synthase, mitochondrial">
        <location>
            <begin position="22"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="122"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01266"/>
        </source>
    </evidence>
    <sequence length="386" mass="43339" checksum="84ACA0D6EAECC691" modified="2010-10-05" version="1" precursor="true">MISRNSILLRRLYPTTIIRTLATDATESTSVKTKRRRTIFTDELNKGPSFDDFVSGKAKDMLEDPLETARKDPNAKLPSWLKVPIPKGKSFHNVKKDVRELKLATVCEEAKCPNIGECWGGKKSEATATIMLLGDTCTRGCRFCSVKTNRKPAAPDPMEPENTAEAISRWGLGYVVLTTVDRDDLVDGGARHLAETVQKIKQKAPQILVEVLGGDFRGDLSMVEILADSGLDVYAHNLETVEALTPHIRDRRATYRQSLAVLERAKQTNSSLITKTSLMLGFGETDDQVLQTLRDLREIGCDVVTFGQYMRPTKRHMKVVEYIKPEKFDYWRDTALDMGFLYVASGPLVRSSYKAGEAFIENVLKKRKHNVGETPRLAQEIKPSIY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>P0CY21</accession>
    <accession>P46594</accession>
    <accession>Q59WV3</accession>
    <accession>Q59XQ8</accession>
    <name>HAL21_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>3'(2'),5'-bisphosphate nucleotidase 1</fullName>
            <ecNumber evidence="1">3.1.3.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>DPNPase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Halotolerance protein HAL21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">HAL21</name>
        <name type="synonym">MET222</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1994" name="Yeast" volume="10" first="1647" last="1651">
            <title>CAN1, a gene encoding a permease for basic amino acids in Candida albicans.</title>
            <authorList>
                <person name="Sychorova H."/>
                <person name="Souciet J.-L."/>
            </authorList>
            <dbReference type="PubMed" id="7725800"/>
            <dbReference type="DOI" id="10.1002/yea.320101214"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 260-364</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Phosphatase that converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP. Regulates the flux of sulfur in the sulfur-activation pathway by converting PAPS to APS. Involved in salt tolerance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3'-phosphoadenylyl sulfate + H2O = adenosine 5'-phosphosulfate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:77640"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine 3',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:10041"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine 2',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:194156"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:77644"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="1"/>
    <dbReference type="EMBL" id="CM000312">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X76689">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0CY21"/>
    <dbReference type="SMR" id="P0CY21"/>
    <dbReference type="PaxDb" id="5476-P0CY21"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016078">
        <property type="term" value="P:tRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000015">
        <property type="entry name" value="3',5'-bisphosphate nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000003">
        <property type="entry name" value="PAP-specific phosphatase HAL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006239">
        <property type="entry name" value="DPNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01330">
        <property type="entry name" value="bisphos_HAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF6">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000413037" description="3'(2'),5'-bisphosphate nucleotidase 1">
        <location>
            <begin position="1"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>adenosine 3',5'-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>adenosine 3',5'-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>adenosine 3',5'-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>adenosine 3',5'-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>adenosine 3',5'-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>adenosine 3',5'-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 2; X76689." evidence="2" ref="2">
        <original>D</original>
        <variation>N</variation>
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P32179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="364" mass="39359" checksum="70687AABBB2C2247" modified="2011-10-19" version="1">MSHTTHPYQKELEVATLAVKRASLLTKQLSDSIVQTARSGTLTKDDKSPVTIGDFALQAIINHAIKLNFPSDEIVGEEDSQELQENSSLADQVLSLIIKIQQETSVYNDVVGTLTDKNKVFQSIDYGNSQGGLKGRFWALDPIDGTKGFLRGDQFAVCLALIEDGKVVLGVIGCPNLLENIVSNEEHSGVVGGLYSAVKGVGSFYSELFKEGAEPLSQQKPIKMQNHTNPSQLKVVEGVEKGHSSHSTQAEIKAKLGFDPTTVAKQTVNLDSQVKYCVLASGQADIYLRLPVSDTYREKIWDHAAGNILIYESGGQVGDVTGAPLNFGNGRTLDSKGVIAANKEIFDKVIDAVTEIRKSSTPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCX6</accession>
    <name>C4YCX6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Alpha-1,2-mannosyltransferase MNN2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_00360</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCX6"/>
    <dbReference type="PaxDb" id="5476-C4YCX6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00360"/>
    <dbReference type="HOGENOM" id="CLU_013298_2_0_1"/>
    <dbReference type="OMA" id="YQYKMLA"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="58"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ42162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="597" mass="69152" checksum="A228EED06F821799" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD14</accession>
    <name>C4YD14_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_00402</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD14"/>
    <dbReference type="PaxDb" id="5476-C4YD14"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00402"/>
    <dbReference type="HOGENOM" id="CLU_049344_1_2_1"/>
    <dbReference type="OMA" id="FRPHYPP"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944134" description="Methyltransferase type 11 domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase type 11" evidence="5">
        <location>
            <begin position="74"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ42200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="367" mass="42299" checksum="85BD186E65F7B3BF" modified="2010-10-05" version="1">MELFLFVHFFFSLYPPTYTNFPNMTTFSKTNFKSLNYNSFRPHYPPSFYKILADYVTKVESPLPINLPIDKTIDLGCGTGVATYPLLNISTNVIGVDLSSKMIETANSLIEKNLQTLGINNPTSTSRIKFITGSVEEFVKQQQQNKDHSVASTLEPNSIDLITAAQCIHWFQDYNSFFQNCHQLLKNDTGVLAYFFYNDPKIVEFSGPAREDIPKEEILKLSYQVYNKYVYDDDNYIGQYWEQPGRNILKHFCQQVNEKIPRDLYTDIVINTFKPSIEKNNSGNTSIANEEVDLDLKKIGISIQDYIDYISTYSGFHNYKEVTGNDDLLTNEFVKEVIEVTGWDLAKTKIDLVWNTGYTFIRKRKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDD2</accession>
    <name>C4YDD2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_00525</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDD2"/>
    <dbReference type="PaxDb" id="5476-C4YDD2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00525"/>
    <dbReference type="HOGENOM" id="CLU_038704_1_0_1"/>
    <dbReference type="OMA" id="ADVKFQM"/>
    <dbReference type="OrthoDB" id="1723750at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ42318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="448" mass="50237" checksum="6ADD9D048BA45DFF" modified="2009-07-28" version="1">MSFSFGFTKDDFSDFSDDDDDELEESNTYIKSNQSFLNGSNSIIQPLNALDSLIITPENKPKLHNLDSILSTLQGIRISFDNYTTPQGNIIYRRELFDVKHQLMIEEEQEEEEEEGNNIGVHKLLIDENQNNNDLQKNVYEGGFKSWECSYDTVDALNKLINGSDSDSDDNNNSLLSSKSILELGCGTALPSCFLLLKKFQSIKESNQLQSSSDSGLRLILSDFNYDVLRLVTVPNLLIHWASTISIEQLHELTSTTNSSNDDGGGGDKIESRFVNDEILITTKLIDQFKNDLNNYNIELQFISGSWGNEFINLPAIKDKDTNGIDIDVIISSETIYSLDTLPIVAESIKTIFQQSSSKSIATSKNNNNNNNNNNKLAIIAAKNIYFGVGGSLIEFLNYFNQITKNDNDDDDNDDHQGQGFNVSVEEINDSQLKRSLVYIDYRGGYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDD4</accession>
    <name>C4YDD4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH-ubiquinone oxidoreductase subunit 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_00527</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDD4"/>
    <dbReference type="PaxDb" id="5476-C4YDD4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00527"/>
    <dbReference type="HOGENOM" id="CLU_067218_0_1_1"/>
    <dbReference type="OMA" id="CMEMYFR"/>
    <dbReference type="OrthoDB" id="204405at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3270:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004538">
        <property type="entry name" value="PRK05888.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004539">
        <property type="entry name" value="PRK05888.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF20">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="9" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ42320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="244" mass="27551" checksum="DD0DDCB1E9DF58EC" modified="2009-07-28" version="1">MFKQIITSSSTKSTRLFTSSTLKYLSTSSSLLKPTLAAAAAASITTTTTDNSSEYLTTGGSTHSIPAKGFRLSQPKTWEESNESALSKATKFLFLSEIARGMYICLEMYFRAPYTIYYPFEKGPISPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIEAEERIDGSRRTYKYDIDMTKCIYCGYCQESCPVDAIVETPNVEYSTATREELLYNKEKLLENGDKWEQELQYCIDADAPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDG8</accession>
    <name>C4YDG8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mtf2-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_00562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDG8"/>
    <dbReference type="PaxDb" id="5476-C4YDG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00562"/>
    <dbReference type="HOGENOM" id="CLU_621116_0_0_1"/>
    <dbReference type="OMA" id="NRRISHH"/>
    <dbReference type="OrthoDB" id="4084661at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043837">
        <property type="entry name" value="Mtf2-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19189">
        <property type="entry name" value="Mtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mtf2-like C-terminal" evidence="2">
        <location>
            <begin position="196"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ42354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="445" mass="51877" checksum="A935A880EC4F9866" modified="2009-07-28" version="1">MRSPNGFLSSQWTRLLVSNRRISHHYTCIRWNHSSSDSQQTRQQVPISPEISGEIDAIGKKSTEKSFEGLSYDLSQLLDEDTLVGKQKDQNQSSEQLPIGSMMESSSDSEPMDFQQLSNFIKEAYEKNPNYKEMERSPSAKRRQVDYFEALFSKYGGTSDRGKKTKTKSSVSDSESDRISSLKEKLRGELTSRCTVALEPTLTHFRTYKTSHELFQTAQTILNNFAKKLQIVGKKTRKTNTSETDSVKLTQIREEIFVQHLFRPIDKNSWLDVHEEYVNNVETQSRLSPENPICDVITLPIIFNEIIDCLAFKFNQGQLAMSLFDLIEKDFSFHTIAVNQDTYNLILRLVWVYYGNTNLDQFYRRYHRMTSLGFTGDVKTLNILKTVYNEYDRLKNGKSIFNNSNSPIYTPEDNIRMEYFEKEYNKLKRRLEHGVQHKDFMLNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDL4</accession>
    <name>C4YDL4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin interacting protein 3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_00611</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDL4"/>
    <dbReference type="PaxDb" id="5476-C4YDL4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00611"/>
    <dbReference type="HOGENOM" id="CLU_005287_0_0_1"/>
    <dbReference type="OMA" id="RFSAYHM"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005519">
        <property type="term" value="F:cytoskeletal regulatory protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1540:FF:000003">
        <property type="entry name" value="Bud site selection protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022782">
        <property type="entry name" value="AIP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005613">
        <property type="entry name" value="AIP3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056279">
        <property type="entry name" value="Aip3p_Bud6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03915">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23153">
        <property type="entry name" value="Aip3p_Bud6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00806">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Actin interacting protein 3 C-terminal" evidence="4">
        <location>
            <begin position="277"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="145"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="562"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ42400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="702" mass="79146" checksum="1CE130F3E730444D" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDN4</accession>
    <name>C4YDN4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAWG_00631</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the C-terminal section; belongs to the AIR synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the GARS family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDN4"/>
    <dbReference type="PaxDb" id="5476-C4YDN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00631"/>
    <dbReference type="HOGENOM" id="CLU_005361_1_0_1"/>
    <dbReference type="OMA" id="EVMQACC"/>
    <dbReference type="OrthoDB" id="2018833at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000006">
        <property type="entry name" value="Phosphoribosylamine--glycine ligase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000006">
        <property type="entry name" value="phosphoribosylamine--glycine ligase, chloroplastic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000001">
        <property type="entry name" value="Phosphoribosylformylglycinamidine cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000018">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.600.10:FF:000001">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000007">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="entry name" value="Phosphoribosylglycinamide synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520:SF12">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01209">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="18">
        <location>
            <begin position="116"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEQ42420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="802" mass="86005" checksum="E793F59EC3FAC812" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDP4</accession>
    <name>C4YDP4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein CMS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDP4"/>
    <dbReference type="SMR" id="C4YDP4"/>
    <dbReference type="PaxDb" id="5476-C4YDP4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00641"/>
    <dbReference type="HOGENOM" id="CLU_086112_0_0_1"/>
    <dbReference type="OMA" id="CVGTPAR"/>
    <dbReference type="OrthoDB" id="1929311at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032704">
        <property type="entry name" value="Cms1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030:SF0">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14617">
        <property type="entry name" value="CMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="35158" checksum="2B625D7D47D9E55A" modified="2010-10-05" version="1">MSKEQQPVADDLDDGLEYDVQLSDNEDAGFVNDGGEEGISNDETEINDNTTTTTTTTATTSSLKRRNSNTNNSLKEKKRLKMEMDIESKKNLSLEENPEIIAEFINNKIRRKNPNLSALELTELYFNKSEIRSTSDFKDTRNLDNLSKYINSRFKNMLPKGVKKDKKKNNKNNKKGKKGDDDSNKDAESENKEERKFIAIVSMSAIRACDIHRATKDLVGSSLKLINKNKLHIDLKLVESTRSRVLCCTPGRLSKVLNSEESGLSKDEIKIVIIDNSYLDTKKQNIWDIKETFEALKELTKNGSKLYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDR1</accession>
    <name>C4YDR1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDR1"/>
    <dbReference type="PaxDb" id="5476-C4YDR1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00658"/>
    <dbReference type="HOGENOM" id="CLU_891363_0_0_1"/>
    <dbReference type="OMA" id="NDANAIH"/>
    <dbReference type="OrthoDB" id="4026019at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097196">
        <property type="term" value="C:Shu complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031779">
        <property type="entry name" value="Psy3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16836">
        <property type="entry name" value="PSY3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="314" mass="36234" checksum="5A787E2CE653150A" modified="2009-07-28" version="1">MKQSKLLDYHVSKSTKIELGLFENTLNFSNNDYGLILYPNRKTFGQHILPQLNNNNNNTNATDSILVISCMDNELLRNNFINFVPCKNYPQLIKILQDLYNCNENSPYFDNATTTTTTTIQILDKHINYILIHNISSFFYDLQIVDQYNYQSLGFEQFNQPDKSPPPDQGNNQPYGKTGKNTKTNIQFNNDDNDDDSTKTHGYYNLLLTLVKKINRKYNCLVVLTSYDIEFDSGLVGSYLYNPNHELQKYTKLPIPFITRFTSTIHISNDANAIHVLNNSTTATAATYPTSDKIEQNKRKHISHLKWQMISKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDT1</accession>
    <name>C4YDT1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDT1"/>
    <dbReference type="PaxDb" id="5476-C4YDT1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00679"/>
    <dbReference type="HOGENOM" id="CLU_033253_0_0_1"/>
    <dbReference type="OMA" id="RVILWKQ"/>
    <dbReference type="OrthoDB" id="4083233at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="479" mass="56107" checksum="18C619F601883412" modified="2009-07-28" version="1">MNENEKESKNVKLGVLEEVANMSVDELTNLEQQLASEFNTLSKEYLESRLSRINTILDKLNSSIKYATANDKSWLKIYNFEIETINSIMTNTEDLIISNNGDLKNKPDLLKSIDEYQEELKEIFKNLQSPFDFDSTFRYDNDDKLNDGSNPNLSKLPFSHLFNDYFKKHRDALNAIIKEKDYQANLLHNNSYGNRVILWKQYYNKLNQQKQKLIDKTNDQLNQLYKDYYHLNEQKNLDFSERHYYRSLLTPQELATTIDDSINTVDTQDVAAVLETNHDSNYVELDTRHKSKNKIEISDIRKKIIDEDQMLNNISCGIKRSWDETDTNGNTDPLKRSRFSLTDAEAIEDLLSIRHNITKQKSQHEQNKNQQNEGIEQNQENQSEAVDIDEAEEEEGQEQSLQHNQEGVEREGEEEEEYGEEMDSDNDREETEAPIESILTSEQKNQRELYKEIIFKNDTTEGMKIQGLPPLDCFPRFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDU2</accession>
    <name>C4YDU2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_00690</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDU2"/>
    <dbReference type="PaxDb" id="5476-C4YDU2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00690"/>
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        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="zf-primase"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM10 OB-fold" evidence="10">
        <location>
            <begin position="175"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger Mcm10/DnaG-type" evidence="9">
        <location>
            <begin position="296"/>
            <end position="340"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="38"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="464"/>
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        <location>
            <begin position="9"/>
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        <location>
            <begin position="62"/>
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        <location>
            <begin position="481"/>
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        <location>
            <begin position="495"/>
            <end position="506"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF09329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ42478.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="598" mass="68927" checksum="DC62B4CA1601E68B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDZ6</accession>
    <name>C4YDZ6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 15">Phosphatidylinositol 3-kinase VPS34</fullName>
            <ecNumber evidence="4 15">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAWG_00745</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Multifunctional phosphatidylinositol 3-kinase involved in acidification of vacuoles, pH-dependent cell growth, and autophagocytosis. Plays an important role in protein transport and virulence. Component of the autophagy-specific VPS34 PI3-kinase complex I essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). Finally, it might also be involved in ethanol tolerance and cell wall integrity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the autophagy-specific VPS34 PI3-kinase complex I composed of at least VPS15, VPS30, VPS34, and of the VPS34 PI3-kinase complex II composed of VPS15, VPS30, VPS34 and VPS38. Interacts with VMNA7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
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    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
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    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08397">
        <property type="entry name" value="C2_PI3K_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PI3Kc_III"/>
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    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
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        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
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    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
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        <property type="entry name" value="ARM-type_fold"/>
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    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
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    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
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        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
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        <property type="entry name" value="PI3/4_kinase_CS"/>
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        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008290">
        <property type="entry name" value="PI3K_Vps34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PI3K_Vps34"/>
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    </dbReference>
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        <property type="entry name" value="PI3K_C2"/>
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        <property type="entry name" value="PI3Ka"/>
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    </dbReference>
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        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2 PI3K-type" evidence="19">
        <location>
            <begin position="49"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="18">
        <location>
            <begin position="331"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="17">
        <location>
            <begin position="666"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="813"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="813"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEQ42532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1020" mass="117488" checksum="72314F9466B423D8" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YE54</accession>
    <name>C4YE54_CANAW</name>
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        <recommendedName>
            <fullName evidence="7">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_00807</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YE54"/>
    <dbReference type="SMR" id="C4YE54"/>
    <dbReference type="PaxDb" id="5476-C4YE54"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00807"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="OMA" id="MTLQDSA"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000097">
        <property type="entry name" value="Amino acid transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF18">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="56"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ42590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="548" mass="59955" checksum="09B7ECF6EE2FC037" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YE89</accession>
    <name>C4YE89_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">A-factor receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_00843</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YE89"/>
    <dbReference type="PaxDb" id="5476-C4YE89"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00843"/>
    <dbReference type="HOGENOM" id="CLU_027592_4_0_1"/>
    <dbReference type="OMA" id="IPPLIWH"/>
    <dbReference type="OrthoDB" id="2874149at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004932">
        <property type="term" value="F:mating-type factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14966">
        <property type="entry name" value="7tmD_STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ42625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="47989" checksum="B3E2CD3AA9BC218F" modified="2009-07-28" version="1">MYKGAAGMGSFLIISFCLLIPPFLWHIRSRNLPATILIFWLMYVDLMGFISTMIWSGDNFDEAWDGQVYCDIVGKLDAGSSVGKCCAIACVIMNLYFVLCAKHPTLLEQGSWKKFAMDMAICLINPIFVMAVHYIVTGSRYAIVKYQGCSTIYSATYASLLLVSIWTVLWSIVALIFAVLTLITFFRKRKDVKDILLCTNSGLNIKRFARLLIFSFLIVFAMVPLSLYYFVSQAEVSKNPFHWDQVHNEEWNVIYFYDFGFFTFYDRLVNCILSVLAFIIFGLGSDALDMYKSMFHKVHNRFWYKKTDEPYSQEQAIKSMEPQTKIDSNKSQFSNTTSFTNTSTMRDIENQFGDVMHQIISEENTSFRFEKQLQSSPATLVKEDGVPRELQSIIKDADSSSDQIFYKYQVKSKSYDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEB0</accession>
    <name>C4YEB0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_00865</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="3"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEB0"/>
    <dbReference type="PaxDb" id="5476-C4YEB0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00865"/>
    <dbReference type="HOGENOM" id="CLU_013572_5_0_1"/>
    <dbReference type="OMA" id="IIKQFLH"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071042">
        <property type="term" value="P:nuclear polyadenylation-dependent mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000006">
        <property type="entry name" value="non-canonical poly(A) RNA polymerase PAPD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000003">
        <property type="entry name" value="non-canonical poly(A) RNA polymerase PAPD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="10">
        <location>
            <begin position="169"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="9">
        <location>
            <begin position="361"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ42646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="603" mass="68757" checksum="80BC19FA0230D384" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEF3</accession>
    <name>C4YEF3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dilute domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_00910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEF3"/>
    <dbReference type="PaxDb" id="5476-C4YEF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00910"/>
    <dbReference type="HOGENOM" id="CLU_019651_0_0_1"/>
    <dbReference type="OMA" id="YAKDWNL"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15473">
        <property type="entry name" value="Myo5p-like_CBD_DIL_ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037986">
        <property type="entry name" value="Myo5p-like_CBD_DIL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dilute" evidence="2">
        <location>
            <begin position="374"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="838"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ42689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="857" mass="98089" checksum="87DABBF7F8099B7C" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEG7</accession>
    <name>C4YEG7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_00924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEG7"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00924"/>
    <dbReference type="HOGENOM" id="CLU_005688_2_0_1"/>
    <dbReference type="OMA" id="YYSYDWL"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ42703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="908" mass="104510" checksum="5F0A4A7E015170DF" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEH7</accession>
    <name>C4YEH7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_00934</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
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                <person name="Berriman M."/>
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                <person name="Lorenz M.C."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
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        <property type="protein sequence ID" value="EEQ42713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="SMR" id="C4YEH7"/>
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    <dbReference type="OrthoDB" id="9805536at2759"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004039">
        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
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        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
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        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F_ATPase_subunit_alpha"/>
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    </dbReference>
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        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="65"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="188"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="418"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEQ42713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="547" mass="59115" checksum="3EE745EDBF7A09DF" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEQ6</accession>
    <name>C4YEQ6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_01014</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEQ6"/>
    <dbReference type="PaxDb" id="5476-C4YEQ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01014"/>
    <dbReference type="HOGENOM" id="CLU_694587_0_0_1"/>
    <dbReference type="OMA" id="QQIHTIP"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000053">
        <property type="entry name" value="BZIP transcription factor AtfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="308"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="167"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="333"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="240"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ42792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="403" mass="43242" checksum="09A110106E3DDC8A" modified="2009-07-28" version="1">MSGMRKTGLTPNESNIRSGLTPGGLTNFGFGSNLVPGLSTPGALLNGPITPGLSSLLGITQTPSSLLVPTTSSFSQNNQSHLIQPAANTSVGPIPESTALGPHVNIPQANQLQQDQSSQALVGGLPPSQPQPQPQPVIAQQIHTIPENQSIAFDMTQPAVANAHLPESKPDLSETANLQRDLNPTADTTTNTTTATKKRKNDTAGGTNKKAKVAKGKKKDPKSKSKGKDNQEDDQNASNKPEDENVPGKENGNEENHKVEAESKEEHLQNGNETTTTKTNNTGKSSNGTTTTTTTKSKSKKNSNVSEDDKRKNFLERNRVAASKCRQRKKLLIQKMEEELEFYSNGYRELSAEVNELRGAILLLKEKHNIQDEIIDGLLSKPTTVPTNVTSIPSTIPTTLNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEU0</accession>
    <name>C4YEU0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Chromo domain protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_01048</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YEU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01048"/>
    <dbReference type="HOGENOM" id="CLU_000315_29_2_1"/>
    <dbReference type="OMA" id="WVQIRDD"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17993">
        <property type="entry name" value="DEXHc_CHD1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000007">
        <property type="entry name" value="Chromodomain-helicase-DNA-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000130">
        <property type="entry name" value="Chromodomain-helicase-DNA-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041150">
        <property type="entry name" value="Cdh1_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056302">
        <property type="entry name" value="CHD1-2/Hrp3_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025260">
        <property type="entry name" value="CHD1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF14">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18196">
        <property type="entry name" value="Cdh1_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13907">
        <property type="entry name" value="CHD1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23588">
        <property type="entry name" value="HTH_CHD1_Hrp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01176">
        <property type="entry name" value="DUF4208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="12">
        <location>
            <begin position="171"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="12">
        <location>
            <begin position="270"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="374"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="678"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="954"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1219"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="969"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1221"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1245"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1275"/>
            <end position="1284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ42826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1410" mass="161722" checksum="2336144A3066DEF3" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEX8</accession>
    <name>C4YEX8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase class V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_01087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEX8"/>
    <dbReference type="PaxDb" id="5476-C4YEX8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01087"/>
    <dbReference type="HOGENOM" id="CLU_003433_3_0_1"/>
    <dbReference type="OMA" id="EFAHHDG"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092:SF2">
        <property type="entry name" value="HERCYNYLCYSTEINE SULFOXIDE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092">
        <property type="entry name" value="L-CYSTEINE DESULFHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="61"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ42864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="421" mass="48145" checksum="E7E618D148090911" modified="2009-07-28" version="1">MSNPIVPFGKQFRAKYFTNMDDEVFPVNHGSYGLTPTPVLEKYLDLIVKNASYTDKFMKYGIKDSYVESLKAVGRVLNCDYHNLAFVDNATSGVNTILRSYPLKKGDKLVIQSTVYGACGNTVKFLHDRYGVEFIVVDLNYPITDEEILSKFERVFVEEKPKLCMFDTISSMPGVVFPYEKMTKLCKKYSVLSLIDGAHGIGCIPQDLGNLKPDFYVTNLHKWFYIPFGCAVLYIDPKHHNVVHTLPISYSYLEDHVKLSDGDQKNRLIDRFFLYGTKNFASIQVIPEAIKFRSEVCGGETKIYDYCHGLAKQVGELVSRKWGTSYLDQKGSTLISTMVTVEVPTQDYPEIVKNWSVIDHHVYNKMFDRKAYTPCIAHNGKLFARFSCQVYNELSDYDYASDVVLETLKEVASEQYKKHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF18</accession>
    <name>C4YF18_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_01129</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF18"/>
    <dbReference type="PaxDb" id="5476-C4YF18"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01129"/>
    <dbReference type="HOGENOM" id="CLU_027285_4_0_1"/>
    <dbReference type="OMA" id="WADWEST"/>
    <dbReference type="OrthoDB" id="941679at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000111">
        <property type="entry name" value="Soluble cell wall protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF14">
        <property type="entry name" value="FAMILY 17 GLUCOSIDASE SCW10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00587">
        <property type="entry name" value="GLYCOSYL_HYDROL_F17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946733" evidence="13">
        <location>
            <begin position="19"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ42904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="567" mass="56657" checksum="FFA881F7AC6F6258" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFA1</accession>
    <name>C4YFA1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_01215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFA1"/>
    <dbReference type="PaxDb" id="5476-C4YFA1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01215"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="OMA" id="DGHEAQW"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ42987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="37243" checksum="311DF3AF7F477B0C" modified="2009-07-28" version="1">MPFVNKSGFFDPSTAPYYDPKETRKVVFITGGNSGIGWYTVLHLYLHGYIVYVAGRTESKVLKAIDDIKAEAENRQAKETTKHPLGELNYIHIDLLDLSTVTKAVDEFAEKEKILDILINNAGLMGVPYEVTKDDYVQYQVNFVAHYLLTLKLLPFLQSAVKIGVTPRIINLASIGHNFQFKHFTPEQNKLDKFPNSVFTWVRYGIAKSSQIQFAKELANHYPDILSVSVHPGVILGTELYNHWKNIPIIGIGARGIFALSDKLIGVSNEEGSLATLRAALDPSLTLKENGEYLITGGKIDEPSKIASNTQYSKETWDWNYEQLKKRGYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFB5</accession>
    <name>C4YFB5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_01230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFB5"/>
    <dbReference type="SMR" id="C4YFB5"/>
    <dbReference type="PaxDb" id="5476-C4YFB5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01230"/>
    <dbReference type="HOGENOM" id="CLU_065898_0_2_1"/>
    <dbReference type="OMA" id="PYEEWSD"/>
    <dbReference type="OrthoDB" id="10253125at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000002">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="9">
        <location>
            <begin position="71"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ43001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="249" mass="26873" checksum="2C269399E1DF2D63" modified="2010-10-05" version="1">MSAEAPKRQFGDRRRGGRRGGRRDGEEKGWTPVTKLGRLVKAGKITSVEQIYLHSLPVKEYQIIDLLLPDLKDDVMKIRSVQKQTRAGQRTRMKAVVVIGDSNGHVGLGIKTAKEVASAIKAAIVIAKLSIIPIRRGYWGSNLGQPHSLPCKVTGKCGSVAVRLIPAPRGKGIVASPVVKRLMQLAGVEDVYTSSSGSTRTTENTLKAAFAAIGNTYSFLTPNLWAETPLAASPLEVYAEEAAAGKKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFF6</accession>
    <name>C4YFF6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">very-long-chain enoyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.3.1.93</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAWG_01269</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) = a very-long-chain (2E)-enoyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14473"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:83724"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="EC" id="1.3.1.93"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.93" evidence="4"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFF6"/>
    <dbReference type="SMR" id="C4YFF6"/>
    <dbReference type="PaxDb" id="5476-C4YFF6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01269"/>
    <dbReference type="HOGENOM" id="CLU_059260_0_0_1"/>
    <dbReference type="OMA" id="ATMPIFN"/>
    <dbReference type="OrthoDB" id="540503at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102758">
        <property type="term" value="F:very-long-chain enoyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000010">
        <property type="entry name" value="Steroid alpha reductase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF28">
        <property type="entry name" value="VERY-LONG-CHAIN ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="258"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="18">
        <location>
            <begin position="153"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00058640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEQ43037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="312" mass="36182" checksum="0273A82C63F676E0" modified="2010-10-05" version="1">MTDIEVKSRSRSIKSFSSNELTPDSSVQELINELSSDNHISEHRLRLTKLENGKQVALIPHKTFAENGIPKTASKIELFVKDLGPQISWRTVFLVEYFGPFIFHPLFYYVQSLYGSGSFEHTQTQKFAFAIVLLHFLKRELETIFVHKFSNATMPAFNIFKNSGHYWILSGFNLAYFIYGPSDKSGVLKYFFHVNELPSSVVYGLFGLWVFAELSNLTTHLILSNLRKGDSKVYVIPFGYGFNWVSCPNYFFESLSWLAYALLVGNWSAWIFLFVSSGQMWLWAVKKHQRYLKSFGDDYKKLKRKIYIPFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFJ2</accession>
    <name>C4YFJ2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="9">1.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">D-lactate ferricytochrome C oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_01310</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="9"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFJ2"/>
    <dbReference type="SMR" id="C4YFJ2"/>
    <dbReference type="PaxDb" id="5476-C4YFJ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01310"/>
    <dbReference type="HOGENOM" id="CLU_017779_3_3_1"/>
    <dbReference type="OMA" id="GQGFEWA"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="12">
        <location>
            <begin position="120"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ43073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="581" mass="63913" checksum="960F4DCF87A6388D" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFJ5</accession>
    <name>C4YFJ5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_01313</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YFJ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01313"/>
    <dbReference type="HOGENOM" id="CLU_000746_0_0_1"/>
    <dbReference type="OMA" id="LEEWHVY"/>
    <dbReference type="OrthoDB" id="26401at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000435">
        <property type="entry name" value="Ubiquitin ligase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046794">
        <property type="entry name" value="Apc1_MidN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049255">
        <property type="entry name" value="Apc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12859">
        <property type="entry name" value="ANAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20518">
        <property type="entry name" value="Apc1_MidN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 N-terminal" evidence="6">
        <location>
            <begin position="41"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 middle" evidence="7">
        <location>
            <begin position="647"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="216"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1535" mass="172828" checksum="96F44F745999EEB1" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFT8</accession>
    <name>C4YFT8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_00064</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFT8"/>
    <dbReference type="PaxDb" id="5476-C4YFT8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00064"/>
    <dbReference type="HOGENOM" id="CLU_003977_0_0_1"/>
    <dbReference type="OMA" id="MAHQCLV"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002058">
        <property type="entry name" value="YML081W-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF13">
        <property type="entry name" value="RESPIRATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1011"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="155"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="400"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ41877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1173" mass="132737" checksum="1E5BF1B1214AF46A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG37</accession>
    <name>C4YG37_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_00153</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YG37"/>
    <dbReference type="PaxDb" id="5476-C4YG37"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00153"/>
    <dbReference type="HOGENOM" id="CLU_1363244_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="57"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ41961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="207" mass="24088" checksum="5529966A7C793616" modified="2009-07-28" version="1">MLDYRVPLPMSYMLIVDLAIDDVESGKAVSLREAACNYNVNMDVLFSRITNNSANNLINPKWQLLSPDDEQKIIDWIIEEEKLSQPVRCYEVMGYAAKLSSITSDVWNPYRWRWFQDFRKRHPEIYMDKGKMFSRKESETEKEQKGVGKPHGKASQTPKANSTKKQKQTPKQKQTKKITKPKTSKRMSEGISTSNIINKPRRTRSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG65</accession>
    <name>C4YG65_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_00183</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase g subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YG65"/>
    <dbReference type="SMR" id="C4YG65"/>
    <dbReference type="PaxDb" id="5476-C4YG65"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00183"/>
    <dbReference type="HOGENOM" id="CLU_083674_1_0_1"/>
    <dbReference type="OMA" id="CAQAYLN"/>
    <dbReference type="OrthoDB" id="437at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006808">
        <property type="entry name" value="ATP_synth_F0_gsu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04718">
        <property type="entry name" value="ATP-synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ41989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="114" mass="12632" checksum="15FB606643D7A79F" modified="2010-10-05" version="1">MSSVITSIVTKTTGLANCAVYWAKVGAELSKAVYKGEGLKPPSSKEFELVYKNALKFIKTPSEQQKFLEQAKNFKPTKECAYKAGIYGIQLLAFFSVGEVIGRRQLTPYVPSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG77</accession>
    <name>C4YG77_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Stress-activated map kinase-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_00198</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YG77"/>
    <dbReference type="PaxDb" id="5476-C4YG77"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00198"/>
    <dbReference type="HOGENOM" id="CLU_007150_0_0_1"/>
    <dbReference type="OMA" id="KWVLQVY"/>
    <dbReference type="OrthoDB" id="241990at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031567">
        <property type="entry name" value="CRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008828">
        <property type="entry name" value="Sin1/Avo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031313">
        <property type="entry name" value="Sin1_PH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335:SF1">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16978">
        <property type="entry name" value="CRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SIN1_PH"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="466"/>
            <end position="603"/>
        </location>
    </feature>
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        <location>
            <begin position="826"/>
            <end position="974"/>
        </location>
    </feature>
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        <location>
            <begin position="73"/>
            <end position="155"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="430"/>
        </location>
    </feature>
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            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
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            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
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            <end position="202"/>
        </location>
    </feature>
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            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
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            <begin position="262"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ42001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="983" mass="111005" checksum="0916A1A0E8BA11FE" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG90</accession>
    <name>C4YG90_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_00211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00211"/>
    <dbReference type="HOGENOM" id="CLU_169795_0_0_1"/>
    <dbReference type="OMA" id="YWNRIIQ"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ42014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="104" mass="12375" checksum="D15BE1840F7C85D9" modified="2009-07-28" version="1">MLCCTLLLTKEPKKHSPKALCMYVTSKIITTESFLFVSFNTLSRNKNFGSRHLAFNSFFLRFTVGFFFSNSTPVKVFVKYSYYYWNRIIQENLEKKKNLVKQQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGB9</accession>
    <name>C4YGB9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_00241</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YGB9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00241"/>
    <dbReference type="HOGENOM" id="CLU_001485_17_0_1"/>
    <dbReference type="OMA" id="ETLGFRN"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:microtubule associated complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000194">
        <property type="entry name" value="AaceriADR145Cp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="57"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="458"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="641"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="829"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="648"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="675"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="687"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="700"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="714"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="728"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="829"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="137"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ42043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="903" mass="100808" checksum="6ECEC1F1E2C1960D" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGK6</accession>
    <name>C4YGK6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SBE2/SBE22 middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_03185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
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                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGW7"/>
    <dbReference type="PaxDb" id="5476-C4YGW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03304"/>
    <dbReference type="HOGENOM" id="CLU_725625_0_0_1"/>
    <dbReference type="OMA" id="IIDSENM"/>
    <dbReference type="OrthoDB" id="5374328at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018287">
        <property type="entry name" value="Hap4_TF_heteromerisation"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10297">
        <property type="entry name" value="Hap4_Hap_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hap4 transcription factor heteromerisation" evidence="3">
        <location>
            <begin position="4"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="127"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="185"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ44999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="319" mass="34320" checksum="92B9014A6020B3B8" modified="2009-07-28" version="1">MLKASKDGVLPPRPKPGRKQKENTTTTTNKESKPKKKYVKKSQRKKELSSSLNSQQQQALHCHEDLSANIDDLPSLMKNISIIDSENMELKSHLLSLIHEYKHLKDIVFKQPIDMFSHNTTPISTTATTTTTTTPTASTTTTTTTTTSTSTTTPEVLSAISLQPSLSSVSSSNNNNQDDPLHQYSSIPSPGSPMSSISTPLPSTTNTNNNVTDGSVSTTTTTTSVGTPKSSIFANPLTILSGSTNVNVNVNGGVSRNTIHIPSILSLDSNVHKRSFDELSEFIDYSEGCSGSGSDGEGELISDLSRTTSSYSDQYLMNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH17</accession>
    <name>C4YH17_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_03358</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Lipid-anchor</topology>
            <topology evidence="10">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YH17"/>
    <dbReference type="SMR" id="C4YH17"/>
    <dbReference type="PaxDb" id="5476-C4YH17"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03358"/>
    <dbReference type="HOGENOM" id="CLU_021855_2_1_1"/>
    <dbReference type="OMA" id="MTAYFNC"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030446">
        <property type="term" value="C:hyphal cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030445">
        <property type="term" value="C:yeast-form cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1040:FF:000011">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF2">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9 10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005125117" description="1,3-beta-glucanosyltransferase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="12">
        <location>
            <begin position="388"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="483"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ45049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="548" mass="59457" checksum="0836AD1428C5769A" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHG8</accession>
    <name>C4YHG8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mediator complex subunit 20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MED20</name>
        <name evidence="5" type="ORF">CAWG_03514</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the Mediator complex subunit 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHG8"/>
    <dbReference type="SMR" id="C4YHG8"/>
    <dbReference type="PaxDb" id="5476-C4YHG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03514"/>
    <dbReference type="HOGENOM" id="CLU_065844_0_0_1"/>
    <dbReference type="OMA" id="WTQRQSI"/>
    <dbReference type="OrthoDB" id="1854899at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013921">
        <property type="entry name" value="Mediator_Med20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12465:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12465">
        <property type="entry name" value="UBIQUITIN SPECIFIC PROTEASE HOMOLOG 49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08612">
        <property type="entry name" value="Med20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ45200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="237" mass="26925" checksum="25DA7897A22C6C22" modified="2009-07-28" version="1">MVTAVLLVQKANLETITQFHDQISNELPTAKGKWNFNFKIFRNNQYSIPQELVDTHEQAPESKFLFTLSPSYLRDSTITLINGKSAGVFTNSIEEELSELGHPSDLSIPNDHLRRGATTGLNDKFDNFIGAKLQSLWTQRQLIKGDGGQIYELENGNLCIRTSNVFLHGNFRGLLIQIEMSNSLCDTNNHNSFKEHFNKIVEKYGFPEGNLCCDVLDKKNLDKYGDLCLQYSKILNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHQ7</accession>
    <name>C4YHQ7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Prephenate dehydrogenase [NADP(+)]</fullName>
            <shortName evidence="9">PRDH</shortName>
            <ecNumber evidence="9">1.3.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_03606</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>prephenate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21640"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8 9">Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the prephenate/arogenate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.13" evidence="9"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHQ7"/>
    <dbReference type="PaxDb" id="5476-C4YHQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03606"/>
    <dbReference type="HOGENOM" id="CLU_031403_1_0_1"/>
    <dbReference type="OMA" id="WRVNACD"/>
    <dbReference type="OrthoDB" id="5399569at2759"/>
    <dbReference type="UniPathway" id="UPA00122">
        <property type="reaction ID" value="UER00962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3660.10:FF:000002">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3660.10:FF:000004">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000339">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3660.10">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050812">
        <property type="entry name" value="Preph/Arog_dehydrog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012385">
        <property type="entry name" value="Prephenate_DH_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363:SF0">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036510">
        <property type="entry name" value="PDH_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="10">
        <location>
            <begin position="13"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ45290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="439" mass="49899" checksum="CF20F5885BE2E41B" modified="2009-07-28" version="1">MAETELKNLQECKTIGIIGLGDMGYLYAKRFSDAGWKVVGCDREDLFETTKAKFTNEKFEILRNGHFVSRISDYIIYSVEAENIEKIVSIYGPSTKFGAIVGGQTSCKAPEIAAFEKHLPEDNEIISLHSLHGPKVNTTGQPLVLIKHRATDKSFEFVEALVSCLNSKQVYLTAKEHDRITADTQAVTHAAFLSMGVAWKSVNQYPWETPRWIGGIENAKINISLRIFSNKWHVYAGLAITNPSAHDQVLQYSKSTTELFTLMIQGKKKELTERLTKAKQFVFKYITNHHDLLLDDNILQKFSLSKTPPEGKQPNSHLSLLAIVDSWYNLGIVPYDHIICSTPLFRIFLGVTEYVFCTPGYLEESIDVAVNDTSFRQDDLNFTIAAQTWSNIISFGNFELYKREFEDTQNFFQPMFQEANAIGNEMIKTILERVKEREC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI68</accession>
    <name>C4YI68_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_03777</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI68"/>
    <dbReference type="PaxDb" id="5476-C4YI68"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03777"/>
    <dbReference type="HOGENOM" id="CLU_005688_1_1_1"/>
    <dbReference type="OMA" id="RIIDPIY"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03874">
        <property type="entry name" value="M28_PMSA_TfR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF72">
        <property type="entry name" value="ZINC METALLOPROTEASE TRE2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M28" evidence="4">
        <location>
            <begin position="405"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="3">
        <location>
            <begin position="661"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ45450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="792" mass="90220" checksum="D7C68521E86B6FB0" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI77</accession>
    <name>C4YI77_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_04149</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI77"/>
    <dbReference type="PaxDb" id="5476-C4YI77"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04149"/>
    <dbReference type="HOGENOM" id="CLU_003818_5_3_1"/>
    <dbReference type="OMA" id="KNWIFST"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF5">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946790" description="alpha-1,2-Mannosidase" evidence="8">
        <location>
            <begin position="25"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="521"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ45812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="842" mass="97144" checksum="5E8F7B6683A0F7D1" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIA0</accession>
    <name>C4YIA0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">V-type proton ATPase subunit F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_04172</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIA0"/>
    <dbReference type="SMR" id="C4YIA0"/>
    <dbReference type="PaxDb" id="5476-C4YIA0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04172"/>
    <dbReference type="HOGENOM" id="CLU_135754_0_0_1"/>
    <dbReference type="OMA" id="IIICQHI"/>
    <dbReference type="OrthoDB" id="10261947at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10580:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005772">
        <property type="entry name" value="ATPase_V1-cplx_fsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01101">
        <property type="entry name" value="V_ATP_synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861:SF2">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015945">
        <property type="entry name" value="ATPase_V1_F_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="AtpF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR015945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ45835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="118" mass="13086" checksum="6A47310A52F242BA" modified="2009-07-28" version="1">MEKRKLVAAIADEDTVTGLLLAGIGQISNEPGKESNFLTVIPGKTTVEQIEEAFTTFTSTRDDIAILLINQHLADLIRFKVDSFSNAFPAILEIPSKDHPYDPEKDSILKKVRKLFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YID5</accession>
    <name>C4YID5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YID5"/>
    <dbReference type="PaxDb" id="5476-C4YID5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04208"/>
    <dbReference type="HOGENOM" id="CLU_091756_0_0_1"/>
    <dbReference type="OMA" id="MIRGNWS"/>
    <dbReference type="OrthoDB" id="4091959at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12622">
        <property type="entry name" value="NpwBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="235" mass="27780" checksum="AEA58185A54EB66B" modified="2009-07-28" version="1">MIRGNWSLADEFKKNEKKQISKIQQRQRDNHKLEKLKAIDPIHLYYKIDRLDQTPNKSEKDNSYLNKLKEDWDFILKYNLHSSKLKPFLENQQKKQQQKLRQQTKLWGQKSIYFNPELNPLGKVPELENLPYKLKDSIENLTVPLKGKQINYSPGPIIKELQIKCPPGQPPRFYKLIQNTSKKNKHNSKSNNTEVLPESETIVNNNSSEENDSPHEEEEEEEEEGGPDFKRYKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIG4</accession>
    <name>C4YIG4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Imidazoleglycerol-phosphate dehydratase</fullName>
            <ecNumber evidence="4 9">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_04238</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="4 9"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIG4"/>
    <dbReference type="SMR" id="C4YIG4"/>
    <dbReference type="PaxDb" id="5476-C4YIG4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04238"/>
    <dbReference type="HOGENOM" id="CLU_044308_3_0_1"/>
    <dbReference type="OMA" id="GIPFFDH"/>
    <dbReference type="OrthoDB" id="447729at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000005">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000001">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="entry name" value="Imidazole glycerol phosphate dehydratase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002114">
        <property type="entry name" value="PRK00951.2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133:SF2">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE HIS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ45899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="222" mass="24109" checksum="4BAE9184E4B6A24E" modified="2010-10-05" version="1">MSREALINRITNETKIQIALNLDGGKLELKESIFPNQSIIIDEHHAKQVSGSQYINVQTGIGFLDHMIHALAKHSGWSLIVECIGDLHIDDHHTAEDVGISLGMAFKQALGQIKGVKRFGHGFAPLDEALSRAVVDLSNRPFAVIELGLKREKIGDLSTEMIPHVLESFAGAAGITIHVDCLRGFNDHHRAESAFKALAIAIKEAISKTGKNDIPSTKGVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIM1</accession>
    <name>C4YIM1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIM1"/>
    <dbReference type="SMR" id="C4YIM1"/>
    <dbReference type="PaxDb" id="5476-C4YIM1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04297"/>
    <dbReference type="HOGENOM" id="CLU_1767808_0_0_1"/>
    <dbReference type="OMA" id="HESAYHS"/>
    <dbReference type="OrthoDB" id="4026086at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013169">
        <property type="entry name" value="mRNA_splic_Cwf18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08315">
        <property type="entry name" value="cwf18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="148" mass="16800" checksum="941FB82F0DAD56E8" modified="2010-10-05" version="1">MSEDRKARLAELRKNRANNRGSSIKASPESQEEGSQDASPPKTPTVLSNDDSQETTEDKEETVSSLPPTLELTNGETVEVVSQRIYNDILNKVHNEATSAFFEQEESTKPKVSYTKDMKDDLQNYYHKAEIRTNRAINKIIQDKLIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIQ2</accession>
    <name>C4YIQ2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 135 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIQ2"/>
    <dbReference type="PaxDb" id="5476-C4YIQ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04328"/>
    <dbReference type="HOGENOM" id="CLU_012946_0_0_1"/>
    <dbReference type="OMA" id="FSWFYEP"/>
    <dbReference type="OrthoDB" id="4021778at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="55552" checksum="25F7E0308C130755" modified="2009-07-28" version="1">MLHPGVRLTKRVYKQSQPLLRKNEHEILLNYSKRLINTTRFLINLSRKSLLKIFKVIFLQRSTLSTFAFAYIFEVLPKLLSSVIHHLFQLKLKGLGNETLKILTDPLDSQRLPIFMTKLVATLNAFTPIYSSILSPHMSNNKLSFYSSFLAAFTSALLNFPSFQHHKLKHDRYYTLDWTLILVTRALDTLIISNFKSIFHTNSKTAKTVGAYGDIVLFVSACFFIMDSWFFEPEKLTPHYAKWITKASHVDENVLLGIRYLRDGELDYHPTKPLPHQNHFKDFCIKYNKDPKLGDLNQIDKIPCEILHQFTTKSCWKHVLILFWVQFKFAFKLYATLNTFLFVFIKKFRGSPLKYLYKTIRSASFLGAFTGIHWAAFCFIRNYHPNWFGQKFWDILAPKAGSALCGTSILLEYPSRRNELSLFVLPKALGTFIDPTPTESNIATEVIAFSLSFAVLIAYARSQPSKLRGLVGKGLSYMVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIU0</accession>
    <name>C4YIU0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM5</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_04368</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ46025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIU0"/>
    <dbReference type="PaxDb" id="5476-C4YIU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04368"/>
    <dbReference type="HOGENOM" id="CLU_000995_7_2_1"/>
    <dbReference type="OMA" id="ITYCKTR"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17756">
        <property type="entry name" value="MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000014">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000015">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000241">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008048">
        <property type="entry name" value="MCM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054125">
        <property type="entry name" value="MCM5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21933">
        <property type="entry name" value="MCM5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01661">
        <property type="entry name" value="MCMPROTEIN5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="326"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ46025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="728" mass="81831" checksum="8C67C0D0FB560126" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIZ0</accession>
    <name>C4YIZ0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIF subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TFIIF medium subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TFIIF-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_03802</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIZ0"/>
    <dbReference type="PaxDb" id="5476-C4YIZ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03802"/>
    <dbReference type="HOGENOM" id="CLU_047858_0_1_1"/>
    <dbReference type="OMA" id="ANCPEHQ"/>
    <dbReference type="OrthoDB" id="26094at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07980">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="12">
        <location>
            <begin position="59"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="11">
        <location>
            <begin position="281"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="355"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ45474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="381" mass="44132" checksum="11504FB099431F8A" modified="2009-07-28" version="1">MSSIKTSPTKKTSESTTKQDTPNDQTNIENFDEEPSMLSDPEDYLEENETLDMNLSKGDQKVWLVKLPKYLMDDWSNPDSMNGQQLGNVKIKKDARGKLQVKLLLDNKNDKIPKEYDIKMLNTQVRNSYVFTEENLKKFKQEVTEVSDMPEQPQLKELNPEKKKFQVRRKFKYFRVQKEGENGQPVKKYIPFVKTIPKKTSLMGKVCHDCTVVPARTGSKHGESLMKHQNMTQGKERPKVTLLNEIPGVIQSNAGPSIKGNAASIFLKSTQGKNKSEGRAIRMPKKDLLDLLFRLFEEYEYWSMKGLKERTRQPESYLKESLESIATLIKRGPYTSKYTLKAEYRRLRDAERAVRLGLDEDDQNKENNEDEDEDEEMEDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ08</accession>
    <name>C4YJ08_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_03820</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="9">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ08"/>
    <dbReference type="PaxDb" id="5476-C4YJ08"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03820"/>
    <dbReference type="HOGENOM" id="CLU_054362_1_0_1"/>
    <dbReference type="OMA" id="MYDTKPV"/>
    <dbReference type="OrthoDB" id="10254187at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000022">
        <property type="entry name" value="NADH dehydrogenase flavoprotein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1590:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
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        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRK07539.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371:SF3">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01257">
        <property type="entry name" value="2Fe-2S_thioredx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ45492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="243" mass="27302" checksum="D2ED7386A855A7E9" modified="2010-10-05" version="1">MLARFIGKSTTTPVGVYASTVSKRYSSIISVHRDTKEDNPNIAFEFNSENKKRAEEIIAKYPPQYKKGACMPLLDLGQRQLGFTSISVMNYVAKLLDMPPMRVYEVATFYTMYNRHPMGKYNLQVCTTTPCQLCGSDSIMKAITDYLKIKPGQTTPDKLFTLQEVECLGACVNAPMIAINDDYHEDLSPEATINLLKQLQEGKELTEIGPVDGKRQSCEPFSGPKVLLNKEPNDIRKFTRADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ81</accession>
    <name>C4YJ81_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_03894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ81"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03894"/>
    <dbReference type="HOGENOM" id="CLU_040321_2_2_1"/>
    <dbReference type="OMA" id="LNCFQYF"/>
    <dbReference type="OrthoDB" id="431202at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="STIMATE/YPL162C"/>
    </dbReference>
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        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735:SF1">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12400">
        <property type="entry name" value="STIMATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ45565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="34749" checksum="5532BA9650C3A09A" modified="2009-07-28" version="1">MTQAILGMLCLSSLLIKRFYEYPIRRTWPVWIFDVSKQLIGALGVHIFNVILSMVKTAPEIWLTQNNNNSSDPDDDNTKDPCDWYFLNIVLDCTIGVYILYHVFKTMNKICRDYWHITQIESGEYGPNPNKPSTKAFLKQLIVYFTSLMITKIILYGLVECFETQLLWFTSHVLLIWLNEYPDEFEIFIVMFIVPIIMNCLQLILIDNFIRNQMWININKRMRLEFPNFSDETESVQQQDIIQAQREEEEEEEQRKYLLMNDSTEGGNNNHSSSSSNDTLLGESHNKSNYGSYNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJG3</accession>
    <name>C4YJG3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="18">SNF2-family ATP dependent chromatin remodeling factor snf21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_03977</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YJG3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03977"/>
    <dbReference type="HOGENOM" id="CLU_000315_15_1_1"/>
    <dbReference type="OMA" id="NPTRETN"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:histone binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140008">
        <property type="term" value="F:histone H4 reader activity"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17996">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000008">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit snf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000843">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit snf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000065">
        <property type="entry name" value="Transcription regulatory protein SNF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014978">
        <property type="entry name" value="Gln-Leu-Gln_QLQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029295">
        <property type="entry name" value="SnAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
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    <sequence length="1680" mass="192399" checksum="1F3A6C6116203AD8" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJT6</accession>
    <name>C4YJT6_CANAW</name>
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        <submittedName>
            <fullName evidence="9">Heat shock protein 78, mitochondrial</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">CAWG_04106</name>
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    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ45770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="700" mass="79181" checksum="241DF75E65382EAC" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJW5</accession>
    <name>C4YJW5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_04136</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YIM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJW5"/>
    <dbReference type="SMR" id="C4YJW5"/>
    <dbReference type="PaxDb" id="5476-C4YJW5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04136"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_1"/>
    <dbReference type="OMA" id="GPLTYFT"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08247">
        <property type="entry name" value="AST1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="30"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ45799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="362" mass="39745" checksum="D399016ED6A97943" modified="2010-10-05" version="1">MTLTTPELNFKAYTYKNSSTPVQLTDKSIKLVKDPSNPDSYVAPPGKILLKINYTSLNPVDVKLHHLATSLVSLLVNNNNGFGRDFSGEVLSIGDNVKTNVKVGDLVQGIYHKVYSQGTASQYLLVDPNEVDMIAKPDNISLAEASSWPTVFGTALLMSKDLKYKDSKVLVIGGGTSVGRYLVQLAKQGGAKEVVVTCSPRTEDVIKSLGADTIIDYTKHKNILYPVLESVKSTGKFDYILDSYGGHELFPEINNILTEKIGRYYSIVGDYPGSSFYNLISTVSKVAWRQLLGALGLLSFNYKFIMLDNFKESMQEARDLIGSGNLKIFVDSIYPFNQLDQAIEKLDSGKAAGKVVIEVAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKG5</accession>
    <name>C4YKG5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glyoxylate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_05968</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKG5"/>
    <dbReference type="SMR" id="C4YKG5"/>
    <dbReference type="PaxDb" id="5476-C4YKG5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05968"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_2_1"/>
    <dbReference type="OMA" id="HHTRAAM"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000026">
        <property type="entry name" value="Glyoxylate/hydroxypyruvate reductase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF257">
        <property type="entry name" value="GLYOXYLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="79"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="139"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ47394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="40223" checksum="CC39B204856F32EF" modified="2010-10-05" version="1">MSSIFKLSTRTIMTSTTTNSIKPKVLRLGITHYAQHKWDQLSKIAEIIDCESTNREEFIHDLQTKYNDITNISRTFASIKQTGRFDNELAKHMPTTLKAISHCGAGYDQIDVTPFTEIGVQISNVTVPVEGPTADTAIYLVLACMRNFQIGHNILVNGEWPQSKNKKKKKISHALSIGNSPEDKVVGILGMGGIGRAIRDRLKPFGFGKIVYHNRNRLSEELEAGAEYLSMDELLNQSDIIIVSVPLNAHTKHLVNKSLIEKMKDGVILINTARGAVIDEKVLPELIKSGKIGSFGADVFENEPEVSPELYELPQVVSLPHMGTYTVEAVRNMESWVVDNIESYIKTGKVKTIVPEQYNAF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKP5</accession>
    <name>IR221_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>Increased recombination centers protein 22-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">IRC22-1</name>
        <name type="ORF">CAWG_06051</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Is probably involved in a pathway contributing to genomic integrity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IRC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKP5"/>
    <dbReference type="SMR" id="C4YKP5"/>
    <dbReference type="PaxDb" id="5476-C4YKP5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06051"/>
    <dbReference type="HOGENOM" id="CLU_078554_0_0_1"/>
    <dbReference type="OMA" id="WLPETYK"/>
    <dbReference type="OrthoDB" id="1926781at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005595">
        <property type="entry name" value="TRAP_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924:SF0">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03896">
        <property type="entry name" value="TRAP_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000399072" description="Increased recombination centers protein 22-1">
        <location>
            <begin position="20"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="20"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="183"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="239" mass="25952" checksum="E798C6D291540A0D" modified="2009-07-28" version="1" precursor="true">MKLSTIFTAFAATIATVAGYETTGSKQTVDILIDYIIKETPELSQNDVANWENGDTVTLQYVVNNNEESEITVVGVTGQFKNPVNNEIVTNLTTGKVGPIAVPPGEAIKFDQKINVDLIPANYELIPYVFIAQDSLIKVIPCRGQLATIVDAAVSFFDPRLIFLELVLLITFAGLIYVGYEIWGKQYFKGVASVKAKKVSAAKASSPVASGPSTTSATGYDTNWIPESHLKQKKTKKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKQ6</accession>
    <name>C4YKQ6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit TIM23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_06062</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKQ6"/>
    <dbReference type="SMR" id="C4YKQ6"/>
    <dbReference type="PaxDb" id="5476-C4YKQ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06062"/>
    <dbReference type="HOGENOM" id="CLU_063935_1_0_1"/>
    <dbReference type="OMA" id="QYIMPEG"/>
    <dbReference type="OrthoDB" id="159299at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005681">
        <property type="entry name" value="Tim23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00983">
        <property type="entry name" value="3a0801s02tim23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ47485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="218" mass="23128" checksum="40EE7B397C7E691A" modified="2010-10-05" version="1">MSWIFGKSSTNNDNNTTTTTNDQSSIKQTLGFDPKEVADVNTIISTPGAISASRLHPLAGLDKGIEYLDLEEEQLNTVEGSKGLIPSRSWTDDLCYGTGAVYLLGLGIGGLYGFQQGIKTLPESAPSKVKLNHILNNITKRGPFLGNSAGVLALTYNLIDSTIDGIREKHDDLNSVTAGALAGALFKSSAGLKPMAYSSVMMAGAAGIWCGLKRFLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL89</accession>
    <name>C4YL89_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL89"/>
    <dbReference type="PaxDb" id="5476-C4YL89"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01606"/>
    <dbReference type="HOGENOM" id="CLU_045999_0_0_1"/>
    <dbReference type="OMA" id="TPRNEDH"/>
    <dbReference type="OrthoDB" id="4024263at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="469" mass="51896" checksum="869CCD173E79B15A" modified="2009-07-28" version="1">MNSSKPSTPVSSPKAQKALSIVVQEPRPQPTTPPPPAQKRQTTFSSRQTKRSSSSFLNTPEPQQQSSQQSSQLSVSGVRDKELNLDSQIPSLPYTPSSKRRSYGIFESPVGRSPYGVALRTPRNEDHDSPEQRSKRYGIVERDNDDDDDDNEYEDEETRHNYTPMGSVGDDEDEESRRLKLQKTPQFHSAKRLYDTLNSVMINNQNSAHNRYMNGIINSGNGQSINKSTTNDSGSNIINKSPNLKTNRHSWSANVNLQFSPSKAPLPPSPQYQQHKLPPPPPPPQPKFTPLTTSNRQPQNQEGQFSPPPQQPQQPQQQPTTPRSSWSISSTPMGVGIASSSISPVYLPPQSSPTKLIIEPNDEEVSAKDAIRKIIQKKRHSGTTSKTNPRTTTTTTTTTNNNNNNADTVAAAAMTLNFKSGRHGNNKHNRNNSYSIKDETEAAFSLVKLQTAAGDDGDDTEDETEDDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLE9</accession>
    <name>C4YLE9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLE9"/>
    <dbReference type="SMR" id="C4YLE9"/>
    <dbReference type="PaxDb" id="5476-C4YLE9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01667"/>
    <dbReference type="HOGENOM" id="CLU_1277469_0_0_1"/>
    <dbReference type="OMA" id="IECIWNG"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="216" mass="24641" checksum="5236745D91D6DA24" modified="2009-07-28" version="1">MSSQVPESEALKIKYKEIAALKKAIQEKQELKRQQQQSASKIQKQAYKRILKLPVNPNVFLQQKPKFSNMTLVVNNTGGSTNGTASATKEGTSSTDQQGYVSVQSSGGKSFYNINVYQQEAEKLKAKILLKKKQVQEQKRLEKIRNQIPKFRTMSDNCDRIKINGDKYAVTENGRALVPIRMFQLTNPIECIWNGNKYQRNSQGVFKLSTPVRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLJ7</accession>
    <name>C4YLJ7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_01715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLJ7"/>
    <dbReference type="PaxDb" id="5476-C4YLJ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01715"/>
    <dbReference type="HOGENOM" id="CLU_004962_0_7_1"/>
    <dbReference type="OMA" id="EDINNWA"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="7">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="116" mass="13101" checksum="DB1D2DCEED8FB118" modified="2010-10-05" version="1">MCDLLWSDPELVNGWSISPRGAGYLFGENEVNKFLHDNNISLIARAHQLVMEGYKEMFNQGLVTVWSAPNYCYRCGNVASVLTIGDDLSREYKVFEASPHDIGSIPSRKPPVEYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLY7</accession>
    <name>C4YLY7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_01859</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLY7"/>
    <dbReference type="PaxDb" id="5476-C4YLY7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01859"/>
    <dbReference type="HOGENOM" id="CLU_013298_1_0_1"/>
    <dbReference type="OMA" id="KGYQYKA"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="75"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ43618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="660" mass="76893" checksum="20C91D1896E29DD8" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-10-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM07</accession>
    <name>SRR1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>Stress response regulator protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SRR1</name>
        <name type="ORF">CAWG_01882</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for stress adaptation, morphogenesis and virulence.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM07"/>
    <dbReference type="SMR" id="C4YM07"/>
    <dbReference type="PaxDb" id="5476-C4YM07"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01882"/>
    <dbReference type="HOGENOM" id="CLU_065405_0_0_1"/>
    <dbReference type="OMA" id="FHKPLNY"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900445">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050595">
        <property type="entry name" value="Bact_response_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44591:SF3">
        <property type="entry name" value="RESPONSE REGULATORY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44591">
        <property type="entry name" value="STRESS RESPONSE REGULATOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000413386" description="Stress response regulator protein 1">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="155"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="41"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="282" mass="32127" checksum="ADABED859BD6E764" modified="2010-10-05" version="1">MISMNPIMIRNNLSRSSSPAAPPTTNHSSTVDYFSIKPKLSLDTNSQSDSNSTQSNNNEDTHSEQSDYNSYTHNQYYDSDDDEDDFDIRDQLLDPFDKITLSNCNEEYYSPLTPFDGQTTSPQDSIISSKSSNKSTTVVPSPQFQLTLPKLTTYSFLIVDDNIINLKILNRILLKLFPKCHIVQIQDSKLVKDLLHKQSFDSIFIDIEMPDVNGIDIAQFVRQDTKFDNMGMVAVTTRNSTQDLELFKQCGIDFTFHKPLNYSLDFMANSIDDIIITRKNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM52</accession>
    <name>C4YM52_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosome biogenesis protein RLP7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_01927</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM52"/>
    <dbReference type="PaxDb" id="5476-C4YM52"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01927"/>
    <dbReference type="HOGENOM" id="CLU_055156_1_0_1"/>
    <dbReference type="OMA" id="VNGWGPQ"/>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000022">
        <property type="entry name" value="Ribosome biogenesis protein RLP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF26">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="3">
        <location>
            <begin position="105"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ43683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="295" mass="33968" checksum="412C1179035908DE" modified="2009-07-28" version="1">MAILNSNPEVLLRKRKNADRKRIEKQEQIRERQLNKNKLKKKNQNKFIRAETLVSNHKSNELERKRIKSLIKKQKQTQQQQESAAADSGDAKLLFLIRIPNHTKGLKLPSKVYKILKDLKLTSVNTGTFVKADSQTMDSLKYIAPYVLVGQPSLTSIRKLFQKRARIMVPDEEQEQEKTTNEQEAGQSEDSESETKQKIIKLDNNQLVEDKFGNDLGLICIEDLIHEISQLSDNFNSITNWLLPFQLNAPVNGWGPQAKLARLLKADENKQKISLAQDFKLQEVEDIDKIIDEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMD6</accession>
    <name>C4YMD6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_02015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMD6"/>
    <dbReference type="SMR" id="C4YMD6"/>
    <dbReference type="PaxDb" id="5476-C4YMD6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02015"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OMA" id="NYQTCYN"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF13">
        <property type="entry name" value="L-XYLULOSE REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ43767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="282" mass="30457" checksum="9A529E5332106C9F" modified="2009-07-28" version="1">MTFTSFIKPESDPNIIVPTKPFNLSPNIVERFSLKDKVTVITGGAGAIGSAIAEGYAQAGGHVIILDHASSDNGLTKRLSSAYGVKSKFFQIDVTNSQQVQQVISQIDEEFGTIDVFVANAGIAWYTGSILNEDSTPENWRRVFDVNVNGVFYCAKYAGEIFKRNGSGSFIITASMSAHINNVPNYQTCYNSAKAAVMHMAKGLAVEFAGFARVNSVSPGYTNTLLSEPIPKPQRAKWWGLTPMGREAETDELVGAYLYLASDASSFTNGSDIRVDGGYCCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YME2</accession>
    <name>C4YME2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone H2A.Z-specific chaperone CHZ1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Histone H2A.Z-specific chaperone chz1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_02021</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CHZ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YME2"/>
    <dbReference type="PaxDb" id="5476-C4YME2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02021"/>
    <dbReference type="HOGENOM" id="CLU_126134_1_0_1"/>
    <dbReference type="OMA" id="RTHYDDE"/>
    <dbReference type="OrthoDB" id="4026566at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019098">
        <property type="entry name" value="Histone_chaperone_domain_CHZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09649">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01082">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone chaperone" evidence="9">
        <location>
            <begin position="99"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="131"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ43773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="165" mass="19464" checksum="5B64D2343E52F541" modified="2009-07-28" version="1">MSDESKPIEEPPIESKPQEEQDTEKESLTNSEESKKRAVEPSTDKKKKRRRRNYDEEDKELEKEEAKEKNAKTENNEEGDDDEDDEDDDYEQGKLEDEEEEEDELLEIDESNIITTGRRTRGKVIDFTKAAEELDKERGVVAEEEEEEEEEEENEDDDFKEQVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMF1</accession>
    <name>C4YMF1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSM3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM3</name>
        <name evidence="11" type="ORF">CAWG_02031</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMF1"/>
    <dbReference type="SMR" id="C4YMF1"/>
    <dbReference type="PaxDb" id="5476-C4YMF1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02031"/>
    <dbReference type="HOGENOM" id="CLU_076902_5_1_1"/>
    <dbReference type="OMA" id="FDSHCNI"/>
    <dbReference type="OrthoDB" id="29543at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01730">
        <property type="entry name" value="LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034105">
        <property type="entry name" value="Lsm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040002">
        <property type="entry name" value="Sm-like_LSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13110">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="13"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ43782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="96" mass="10905" checksum="2344FB402B0F8580" modified="2009-07-28" version="1">MSTIQAEQQQDQQPLDLIRFQLDEYVLVKLRGARELKGKLQGYDSHCNMVLSDAEETIYTSNEDDDSENTSEEPIVKKTAMVFVRGDSVILISPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMM2</accession>
    <name>C4YMM2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial ATPase complex subunit ATP10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_02105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMM2"/>
    <dbReference type="PaxDb" id="5476-C4YMM2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02105"/>
    <dbReference type="HOGENOM" id="CLU_047290_2_0_1"/>
    <dbReference type="OMA" id="YFPNFHG"/>
    <dbReference type="OrthoDB" id="17089at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007849">
        <property type="entry name" value="ATP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106:SF1">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05176">
        <property type="entry name" value="ATP-synt_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="33454" checksum="0A41F2E7A63A6289" modified="2009-07-28" version="1">MQSVFIRTFATSKIEFQRYQPRFVNTIKETVKSAQEKSYSITRPLGLSKPVLLNHKLSDTYSLSNIYEELFGQKSKERRQKQLDYDLKHSPIYEVKSFENTKGKIFTPPVSYFRQDKSLYFPDFIAKTLAGNQRSLYDSLDNRLSIVKLFSSVAGEQCTRSYFKVENKDYYSQDYDTFVEEYPHTQILDVNMPQSWIKGFVTNLSTGNLRKTLKPASRYENYFILPGHIMSAEIREQLYCDNQCSGYIYIVDSMGKIRWATSGYATPEDLKLMWKVVKGVQREMTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMR9</accession>
    <name>C4YMR9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JAB1/MPN/MOV34 metalloenzyme domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMR9"/>
    <dbReference type="PaxDb" id="5476-C4YMR9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02153"/>
    <dbReference type="HOGENOM" id="CLU_013700_1_0_1"/>
    <dbReference type="OMA" id="NTERTKC"/>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JAB1/MPN/MOV34 metalloenzyme" evidence="1">
        <location>
            <begin position="483"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="717" mass="82045" checksum="1883CFF924472034" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMZ5</accession>
    <name>C4YMZ5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="2 7">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_02232</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-formylglutathione + H2O = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the esterase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="2 7"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMZ5"/>
    <dbReference type="SMR" id="C4YMZ5"/>
    <dbReference type="ESTHER" id="canal-q59nl9">
        <property type="family name" value="A85-EsteraseD-FGH"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YMZ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02232"/>
    <dbReference type="HOGENOM" id="CLU_056472_0_1_1"/>
    <dbReference type="OMA" id="PSDCPWG"/>
    <dbReference type="OrthoDB" id="420518at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000002">
        <property type="entry name" value="S-formylglutathione hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="303" mass="34264" checksum="ACB7B7D0CC121D26" modified="2010-10-05" version="1">MSFKTNATIIQFGGILHKLSHDSALTKTPMDVNVFIPPINPTSTTKQKIPVLIYLSGLTCTPQNATEKSFFQYWASKYGFAIVFPDTSPRGAKIEGEDDSWDFGTGAGFYVDATQSPWNKNYQMYSYIHKELLDKLSEQFIELDFENNIGITGHSMGGMGALVGFLTQPKKYKSISAFAPISNPSIVQWGEKNFGNYLGNDDKQNWYKYDPTHLIKQYTTTNDYQPSILIHQGLNDNFYADQLKPENFVKAAKEANYKGEIDLRLVDGYDHSYFFISSFVEDHAKHHAKYLGLTTTTTTTKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNE8</accession>
    <name>C4YNE8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNE8"/>
    <dbReference type="PaxDb" id="5476-C4YNE8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01407"/>
    <dbReference type="HOGENOM" id="CLU_657195_0_0_1"/>
    <dbReference type="OMA" id="GNNHKTK"/>
    <dbReference type="OrthoDB" id="10693763at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="271"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="418" mass="48723" checksum="D0735BD405F5E2A7" modified="2009-07-28" version="1">MSNFYKKWKLQDAFQIRNNLQSTNSHSNKFVKKRLDRIYIDSRIRKKLRDCRLLEEFKQISTHKIIAMSLQIQKEPILKVGNPRYSIPQWMSQDENIIKDLNNNEQGSLTPFSNWNGIINQIQEKVIFYKKYQRYIRAYIPHAGNFPDEKMLKFRFRPSFNFSIITEMQTESGNTVQDTEIMINLATKFYQDLFSVEDRHLESFTFVDQFDKKIDETDKVLLEKAFIEDNVYDHLLMINKKTAVGTDGISYQNLIELWPSLSESLIRAGNNILKYGTLPQQMSEVIITLIPKKSKTPIIENFRPISVISCAVRLLSSVIEKQLNPVLAKVIENTQTGFLKKRSISNSIYFLDMVLTRYQTSKTAEAESAGLVNLDFRKAFDSVHHDFVLLVLRQVGLEPKATNFFDGNNHKTKSKSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNH2</accession>
    <name>C4YNH2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">JmjC domain-containing histone demethylation protein 1</fullName>
            <ecNumber evidence="5">1.14.11.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">[Histone-H3]-lysine-36 demethylase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CAWG_01433</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(36)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:42032"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:9787"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.11.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the JHDM1 histone demethylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.27" evidence="5"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNH2"/>
    <dbReference type="PaxDb" id="5476-C4YNH2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01433"/>
    <dbReference type="HOGENOM" id="CLU_003540_6_2_1"/>
    <dbReference type="OMA" id="SVYYTVC"/>
    <dbReference type="OrthoDB" id="5876800at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140680">
        <property type="term" value="F:histone H3K36me/H3K36me2 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041070">
        <property type="entry name" value="JHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050690">
        <property type="entry name" value="JHDM1_Histone_Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23123">
        <property type="entry name" value="PHD/F-BOX CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17811">
        <property type="entry name" value="JHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="20">
        <location>
            <begin position="5"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="21">
        <location>
            <begin position="217"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EEQ43205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="478" mass="55460" checksum="2E28D1EF0495DA17" modified="2009-07-28" version="1">MPINSESCPLCKVHSNTIKKEDEDEEDNKTSWIQCSKCKVWYHVHCLDLPTDEIDQIVIYHCPECVPKYGESTYKRKSKRARVSIDYQSLNEGDTFAIDKSSHFHLHIFLNFKGETNINVIDKLTKTYALNTQMEKPILIPQADLSKNGMQLPIEKNEITIDYITDCCGEDTPLEVMDVISQQGISPPWKLKQWREYFKTNEEKRDRIRNVISLEISDVAKLGVDFTRPKCVRDMDVVDRVWIEEDEQKRSKVTKYCLMSVKNSFTDFHIDFGGTSVYYTVLSGAKTFLFFPPTDNNLELYKSWCLEPSQNFIWYPEYTITKNKKKIKPTGGFKVDLQPGDLFIIPSGWIHAVHTPQDSIVIGGNYLTIRDMVMQLKINEIERETKVPTKFRFPMFNKVLWLTAWYYYNHQNEFQSDISEDEDGNAILTRLIGHLQGHLELSKTNATAKRSIPKAIGKPMVFINKLLAWKEDLYGTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNP6</accession>
    <name>C4YNP6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_02827</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNP6"/>
    <dbReference type="PaxDb" id="5476-C4YNP6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02827"/>
    <dbReference type="HOGENOM" id="CLU_012062_0_2_1"/>
    <dbReference type="OMA" id="RVCQNKF"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF6">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="162"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="246"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="123"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="394"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="404"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ44555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="475" mass="51645" checksum="C75A4E660D33F269" modified="2009-07-28" version="1">MSLEDDEALFEDLYGDDEKQEEKQDTVQKEVESTEKETTAVETASATENASSAEVETTTEGESESVPPPPPPPIPASGDVNAQSNTAQDNATSTAPGSVPAGMPQFPFDPAQFQQYAAANGLQFPGNANQQNFGAAGGVPPPPPPAPTANATSAESAGGPSRKCFIGGLSWDTTEEALVSHFQKYGNIVDYTIMKDSATGRSRGFGFLTFEDAKSVDALLKDRHVLDGKLIDPKRAISKEDQEKVGKIFVGGIDPMVTEEEFDNFFSQFGKIIDCQLMIDKDTGRSRGFGFVTYDSPAAVDKVCVNKYLTLKGKAMEVKRAAPRGQHNQQVMMQQQQQQQQQQAQQQAQQQAMYPYGSYGFQQMNPGAMNPAMSQEYMRYYQWFMYQQAQAAQQQQQSGTSASPEAQPAQPLNPQQQAAEEESEKSDEQARPAIPTGPKRAPPTGPSYRGGGRGGGRGGYRRGRGYHPYSRGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNS0</accession>
    <name>C4YNS0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNS0"/>
    <dbReference type="PaxDb" id="5476-C4YNS0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02853"/>
    <dbReference type="HOGENOM" id="CLU_2333425_0_0_1"/>
    <dbReference type="OMA" id="AFTFIED"/>
    <dbReference type="OrthoDB" id="4026725at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="109" mass="12844" checksum="4A4207CA1F2044C7" modified="2009-07-28" version="1">MEFIAFTFIEDSILLRLFLVLFILLVTYAVIIYLIETLFINRYPFVNINTDKVEAPDLFLSVNSARNQTTKLLNRETFYKNLNNSSQYLRRDSYSANEFYSTPTTNIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNV7</accession>
    <name>C4YNV7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen54 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_02890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN54 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNV7"/>
    <dbReference type="PaxDb" id="5476-C4YNV7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02890"/>
    <dbReference type="HOGENOM" id="CLU_028449_1_0_1"/>
    <dbReference type="OMA" id="FNVWKPQ"/>
    <dbReference type="OrthoDB" id="408683at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024337">
        <property type="entry name" value="tRNA_splic_suSen54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024336">
        <property type="entry name" value="tRNA_splic_suSen54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12928">
        <property type="entry name" value="tRNA_int_end_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen54 N-terminal" evidence="4">
        <location>
            <begin position="87"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="359"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ44616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="469" mass="55017" checksum="337E836E37AE3A9E" modified="2009-07-28" version="1">MTDEQLESKTSKGKQNRNRNIDNDNENDNDNEDDKFQTEQVYDVEDEIQDWKFLNKSTIPKRGTKEFEPDGTNYQISALEQSQQTMFQAINNVRGHHTTKKLIGIWMIDEHDQYCFIPQIRGNYFKDLGKAINIGKFQGMKLNSLETIYLAERGSLIVYLGNQEYSDWLYNSAEVEENEDGDKNVSFDVESNLIALDLEYLYSLLTIPLANYQVYAYLKRLGYIIQEYKVQDDVMDKTLLSSSPTKDPKKLESLVRFTLWPREWGIMAYPFFHSLHFKTKHYFKYTDVFKNLKLNFKPIESNPNESNINITFNVWKPSPSFSKKTPPPPDFQLCVVDSSKNTDFLKLPQIQRLFFQLSPPPSQQQQQKQNLFKKTKPSTKMESKRDIRARRYAERQAKLDKQLQLKNEYYRLRDDCFKNGGQSVIIAIVNNGIMNFISLSSGQFDSLQNVKTRLNEIYPKKIHSIIYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP04</accession>
    <name>C4YP04_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="5">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_02939</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="5"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YP04"/>
    <dbReference type="SMR" id="C4YP04"/>
    <dbReference type="PaxDb" id="5476-C4YP04"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02939"/>
    <dbReference type="HOGENOM" id="CLU_021152_3_1_1"/>
    <dbReference type="OMA" id="KCTIFLP"/>
    <dbReference type="OrthoDB" id="7773036at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06448">
        <property type="entry name" value="L-Ser-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000040">
        <property type="entry name" value="L-serine dehydratase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF2">
        <property type="entry name" value="CATABOLIC L-SERINE_THREONINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="11">
        <location>
            <begin position="15"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ44663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="332" mass="36132" checksum="B9F73433008C41B8" modified="2010-10-05" version="1">MKEPSITTTFVEVTDKLPTKPPCRVFFKNEYEQPSGSFKLRGMGHLVGQSIDVARKLGKSNVAVFSSSGGNAGLAAAYASQFFGVSCTVVLPESSKPTVIEKLKSLGADVIIHGKHWGEADNYLTDFVIKNLDKTVYPVYCHPFDDPLLWEGHSKIITEIIDQKQLPNFDKVKGVICSVGGGGLYNGIVEGLENHKEIPVLAIETKQAATFHEAVKEGKVVHLQKVQTLATSLASPYLSSKALANYIERPTVLAEIDDLDAVKGVVDVYDHFGYMVEPACGASVASVMHRQDLLNKFGTLSPDDIIIVVICGGSAINKYIIDEYRSLLEKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP35</accession>
    <name>C4YP35_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YP35"/>
    <dbReference type="PaxDb" id="5476-C4YP35"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02971"/>
    <dbReference type="HOGENOM" id="CLU_059406_0_0_1"/>
    <dbReference type="OMA" id="EIWVRKF"/>
    <dbReference type="OrthoDB" id="3993315at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="362" mass="40815" checksum="0E321D298D5801BA" modified="2009-07-28" version="1">MPETEVINNSTTNNLDENNASSSITPENKITNPTDSSIIEDSNNNNNNTSKLSLPSPSISSISSLDSNNSTEKLINSLANSSLNETKTNEKVSEDSTNKSTLIITQLDPETLSESEKRQLQRQNRIPQSFHSKTKFYDELSQASVDVGPTTTQESVAVPVQRPPEQKPIDGSEPGTTESNTFIALPKKIKKFTVRKISNPEAITSPTSSPNPSKEPLRQPKFSPTNTKFNVTPHVSPIVSYSENKSQGQSQSRKSSVNSNGDSQKHKHQQELHKLRKIEEKYDQYELRIEKIDKEIAYLKKLLPPYNVQIDYNTRVKINKAIEKLSMKKDEIDKKKYDLGITISRLWRNLGDGKEIWVRKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP65</accession>
    <name>C4YP65_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_03008</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YP65"/>
    <dbReference type="PaxDb" id="5476-C4YP65"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03008"/>
    <dbReference type="HOGENOM" id="CLU_007727_0_2_1"/>
    <dbReference type="OMA" id="GKIMEWY"/>
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    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10004">
        <property type="entry name" value="RPD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="14">
        <location>
            <begin position="37"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="412"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="437"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="506"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="547"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ44724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="577" mass="65379" checksum="AA5EA43BDEDC12EB" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPF4</accession>
    <name>C4YPF4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Allantoinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_02353</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPF4"/>
    <dbReference type="PaxDb" id="5476-C4YPF4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02353"/>
    <dbReference type="HOGENOM" id="CLU_015572_4_0_1"/>
    <dbReference type="OMA" id="SRLHVCH"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000209">
        <property type="entry name" value="Allantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF2">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="62"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="367"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ44094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="586" mass="64495" checksum="52C1B67745FA8AD2" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPU2</accession>
    <name>C4YPU2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase catalytic subunit A</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAWG_02495</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Vacuole membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPU2"/>
    <dbReference type="SMR" id="C4YPU2"/>
    <dbReference type="PaxDb" id="5476-C4YPU2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02495"/>
    <dbReference type="HOGENOM" id="CLU_008162_3_1_1"/>
    <dbReference type="OMA" id="RIVKTFW"/>
    <dbReference type="OrthoDB" id="1676488at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18119">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000008">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000052">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000003">
        <property type="entry name" value="Vacuolar ATP synthase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005725">
        <property type="entry name" value="ATPase_V1-cplx_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003220">
        <property type="entry name" value="PRK04192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01042">
        <property type="entry name" value="V-ATPase_V1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="16">
        <location>
            <begin position="2"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="ATPsynthase alpha/beta subunit barrel-sandwich" evidence="17">
        <location>
            <begin position="91"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="15">
        <location>
            <begin position="197"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="18">
        <location>
            <begin position="430"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEQ44231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="577" mass="63290" checksum="823A2E69CC589C53" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ27</accession>
    <name>C4YQ27_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Biogenesis of lysosome-related organelles complex 1 subunit KXD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">KxDL homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_02581</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KXD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ27"/>
    <dbReference type="PaxDb" id="5476-C4YQ27"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02581"/>
    <dbReference type="HOGENOM" id="CLU_092512_0_0_1"/>
    <dbReference type="OMA" id="RITKLMH"/>
    <dbReference type="OrthoDB" id="4089816at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051390">
        <property type="entry name" value="BLOC-1_subunit_KXD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019371">
        <property type="entry name" value="KxDL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37787">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT KXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37787:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT KXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10241">
        <property type="entry name" value="KxDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="KxDL" evidence="9">
        <location>
            <begin position="110"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ44316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="242" mass="27671" checksum="6C2BD052A4A61126" modified="2009-07-28" version="1">MQDLDTPKEVSQAIRQANTDEEANIENGNESQQQQQHNNRQQEPENHTNEIITNSNNSTDSTFSDTEDDYMLSDDEELNRILSRETSSHHHGLPSSGSMVDHAQFFAEALSHALDSIDIDRSLVLQAQISGKLNNENQKIIEKKEILIEKLKNIQLMYGKNFGLLADGKESRVDKMKKDISFIENRITKLMHGGSETKSSIPFFKNKSNMGVEQKYPIEFNQAKDKVIERQIDDDDNEEIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ74</accession>
    <name>C4YQ74_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body-associated protein Vik1/Cik1 microtubule binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ74"/>
    <dbReference type="PaxDb" id="5476-C4YQ74"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02629"/>
    <dbReference type="HOGENOM" id="CLU_449032_0_0_1"/>
    <dbReference type="OMA" id="CISIKNG"/>
    <dbReference type="OrthoDB" id="4089036at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="257"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="617" mass="71386" checksum="CF96EDAEA02C1B52" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQA2</accession>
    <name>C4YQA2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YQA2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02658"/>
    <dbReference type="HOGENOM" id="CLU_018538_0_0_1"/>
    <dbReference type="OMA" id="WFEDSNI"/>
    <dbReference type="OrthoDB" id="4090081at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF27">
        <property type="entry name" value="LRRNT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="813" mass="93883" checksum="EDD9C22F7475D2C3" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQQ2</accession>
    <name>C4YQQ2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rho GDP-dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_02812</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQQ2"/>
    <dbReference type="SMR" id="C4YQQ2"/>
    <dbReference type="PaxDb" id="5476-C4YQQ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02812"/>
    <dbReference type="HOGENOM" id="CLU_076228_1_0_1"/>
    <dbReference type="OMA" id="YKPTAAK"/>
    <dbReference type="OrthoDB" id="1683373at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.30:FF:000001">
        <property type="entry name" value="Rho GDP-dissociation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ44541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="203" mass="22962" checksum="E8C3527C172C69E9" modified="2010-10-05" version="1">MSNSNVDDDLVPEKVEGYTVGEKKTIDEYKNLDAEDESLAKWKASLGLTADTKPYPVKPGDKRKVVVTELALEFPEQPDLQPIRINLEDSDGNTIVDKEIKFNIKEKSIYQLVVKFRVQHEIITGLKYLHSVKRGGIRVEKVEEPLGSYAPNTIDKPFYERKFAEVEAPSGMIARGTYSAISKFIDDDDNVHLTVPWSFSITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQX3</accession>
    <name>C4YQX3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="21 22">Folic acid synthesis protein fol1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CAWG_04470</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19 22">Catalyzes three sequential steps of tetrahydrofolate biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 22">In the C-terminal section; belongs to the DHPS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 22">In the N-terminal section; belongs to the DHNA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20 22">In the central section; belongs to the HPPK family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQX3"/>
    <dbReference type="PaxDb" id="5476-C4YQX3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04470"/>
    <dbReference type="HOGENOM" id="CLU_008023_2_0_1"/>
    <dbReference type="OMA" id="ESEPMYF"/>
    <dbReference type="OrthoDB" id="615426at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.20:FF:000014">
        <property type="entry name" value="Folic acid synthesis protein fol1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1130.10:FF:000010">
        <property type="entry name" value="Folic acid synthesis protein fol1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="entry name" value="7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016261">
        <property type="entry name" value="Folic_acid_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="FOLATE SYNTHESIS PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941:SF1">
        <property type="entry name" value="FOLIC ACID SYNTHESIS PROTEIN FOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000741">
        <property type="entry name" value="Folic_acid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16 22" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="13 22" id="KW-0418">Kinase</keyword>
    <keyword evidence="17 22" id="KW-0456">Lyase</keyword>
    <keyword evidence="15 22" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 22" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="23">
        <location>
            <begin position="469"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00058009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00061548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00067568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRNR" id="PIRNR000741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EEQ46126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="788" mass="88485" checksum="4270F48A9F8757A8" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR19</accession>
    <name>C4YR19_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-demethoxyubiquinone hydroxylase, mitochondrial</fullName>
            <shortName evidence="8">DMQ hydroxylase</shortName>
            <ecNumber evidence="8">1.14.99.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ubiquinone biosynthesis monooxygenase COQ7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">COQ7</name>
        <name evidence="10" type="ORF">CAWG_04517</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + AH2 + O2 = a 3-demethylubiquinol + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50908"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="1.14.99.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="8">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the COQ7 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.60" evidence="8"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR19"/>
    <dbReference type="PaxDb" id="5476-C4YR19"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04517"/>
    <dbReference type="HOGENOM" id="CLU_071892_0_0_1"/>
    <dbReference type="OMA" id="WSTAVMG"/>
    <dbReference type="OrthoDB" id="275371at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01658">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ46172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="246" mass="27505" checksum="389621A218CA3212" modified="2009-07-28" version="1">MLSRTTTYSVRQMSSTSALLNKSTKPKSKAPKKKSQKEVTYGPLSDAQKAYLDRVIRVDQAGELGANYIYMGQYAVLASKYPHLKPVLHHMWEQEIHHHNTFNKLQTKRRVRPSLLTPLWKLGAIGMGVGTALIGKEAAMACTVAVETVIGGHYNQQLRVLSNQYGVPIYDKKTGALLSPDAVEKTAQTSEELTELKNQISEFRDDELEHLNTALDHDAEKAVPYMLITEGIKLICRGAIWTAERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR85</accession>
    <name>C4YR85_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_04584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR85"/>
    <dbReference type="PaxDb" id="5476-C4YR85"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04584"/>
    <dbReference type="HOGENOM" id="CLU_1901161_0_0_1"/>
    <dbReference type="OMA" id="FLRNDHY"/>
    <dbReference type="OrthoDB" id="10419055at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="121" mass="14244" checksum="7300DBC51956F1EC" modified="2009-07-28" version="1">MARNKNIIPHSPSRSLSYNLNTHPPLSTTTKCYDKNYYLTLKNSQSMYIHNIVFLRNDHYFSFSLGCGLFVSVYDPLKVLQSCGKQYYVRYHHKNNLSQIVEFWIAKPFVDTLEERLEKAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRT1</accession>
    <name>C4YRT1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE affecting a late Golgi compartment protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_04788</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRT1"/>
    <dbReference type="SMR" id="C4YRT1"/>
    <dbReference type="PaxDb" id="5476-C4YRT1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04788"/>
    <dbReference type="HOGENOM" id="CLU_061883_0_2_1"/>
    <dbReference type="OMA" id="ERASDCC"/>
    <dbReference type="OrthoDB" id="546861at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21444">
        <property type="entry name" value="SNARE_NTD_Tlg1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15851">
        <property type="entry name" value="SNARE_Syntaxin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000006">
        <property type="entry name" value="Syntaxin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048036">
        <property type="entry name" value="Tlg1p-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF224">
        <property type="entry name" value="HL02043P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="13">
        <location>
            <begin position="135"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="36"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ46434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="227" mass="26308" checksum="374D0556C73369A1" modified="2010-10-05" version="1">MDPFNEVKEDAYASIRALDNIINLRPNGKPPTNEQQQDFENSFQELQEIYRDLQQALSISESQPSKFNLSDIDISNRKSILSDLNNQIQHLEKKWNQKQYRDVTTMSNRISQDGQEDEDIDPFSADSAMTSYQQQELIQEQDLQLDDIHRTMMNLNQQAAIMGDELEEQGFMLDELDYEMDNVDNKLQRGMKSINIFLERNKETASNWCIGILVVVLCVLLVLLLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRU1</accession>
    <name>C4YRU1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRU1"/>
    <dbReference type="PaxDb" id="5476-C4YRU1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04798"/>
    <dbReference type="HOGENOM" id="CLU_1360242_0_0_1"/>
    <dbReference type="OMA" id="IDLESMQ"/>
    <dbReference type="OrthoDB" id="10342566at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="23254" checksum="6AAD12DAFA1F19F6" modified="2009-07-28" version="1">MSTTRIYIGVFFRFSQFVGNVGCFATSVNTLRPYNAFILTFTVLNFIYNCYIWFGVPIIGGLKAYNGILLGGEISFFFLYIGSSMFQAFAGYTDDWTEDDFGFSFNPYCYYASWAIGVICAALYIITFIMYVCWGLIPASRYGFSTGFFERPPFKFGCLVFDKSQVDHNCEDNKDIDLESMQHSTSNNTGTKQNEVEKQESIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRW2</accession>
    <name>C4YRW2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRW2"/>
    <dbReference type="PaxDb" id="5476-C4YRW2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04819"/>
    <dbReference type="HOGENOM" id="CLU_180915_0_0_1"/>
    <dbReference type="OMA" id="KHIMNGN"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="76" mass="8686" checksum="A7FFB196622429EF" modified="2009-07-28" version="1">MKHIMNGNSSSSRKSKLSPIRTFRGAEFMTQNETKCPKVVDYSSQRLPLGENPTSIFDDNSYNRDSDLKTRLTTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSK5</accession>
    <name>C4YSK5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-C homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_05073</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-C/MIF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSK5"/>
    <dbReference type="PaxDb" id="5476-C4YSK5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05073"/>
    <dbReference type="HOGENOM" id="CLU_527842_0_0_1"/>
    <dbReference type="OMA" id="RDIHNIP"/>
    <dbReference type="OrthoDB" id="1939643at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051455">
        <property type="term" value="P:spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06993">
        <property type="entry name" value="cupin_CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000033">
        <property type="entry name" value="Centromere protein C 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028386">
        <property type="entry name" value="CENP-C/Mif2/cnp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025974">
        <property type="entry name" value="Mif2/CENP-C_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028929">
        <property type="entry name" value="Mif2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684:SF11">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11699">
        <property type="entry name" value="CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15624">
        <property type="entry name" value="Mif2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mif2 N-terminal" evidence="9">
        <location>
            <begin position="4"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Mif2/CENP-C cupin" evidence="8">
        <location>
            <begin position="427"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="332"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF15624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ46708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="521" mass="58490" checksum="066AA8407F0409CE" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSM1</accession>
    <name>C4YSM1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_05089</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSM1"/>
    <dbReference type="PaxDb" id="5476-C4YSM1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05089"/>
    <dbReference type="HOGENOM" id="CLU_048297_2_0_1"/>
    <dbReference type="OMA" id="SCWGMPN"/>
    <dbReference type="OrthoDB" id="204164at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF6">
        <property type="entry name" value="MANNAN POLYMERASE COMPLEXES SUBUNIT MNN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ46724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="432" mass="49963" checksum="1FA4CAE90CC34FB0" modified="2009-07-28" version="1">MLSAELKRRKKLLLPLALISGIIVLLFFTNYNYSFTTSSHPVLSSSHKSNNAFPTLDQTSSTKARPNPGNLIANQKDKSQTGTYFTKFIHKDPQFDFTKITYTSTNKKFKTNNIKVDEETGDTTEVVNKPTVLIMSVIGNNEPYGSDRHFDGFMLTILSLVENQPDYEFSLGLLNNNEEEFIKIQNYFEKNLQKELSETLSSIFKSISLISAPFLDQNTGFSREQRHDDHVQRLRRRLIAKSRNFLLLNTLNLEQYVLSLDADMIRFDNPEKFIKTFIDSKKDIIVPRIQRLDMQDYDKNSWRGQRTKPTKEQLEKMDNNQWDQWDYVPRDVKDHMYHFQTYMDNKDNEYELHKEEYDYVVPLDSVGGAVLFAKSIVFKQGVIFPTSLIVGTTWDRQEGYDGIETEGVCYLAKPLGFSCWGMPNVVAHHSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSV8</accession>
    <name>C4YSV8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSV8"/>
    <dbReference type="SMR" id="C4YSV8"/>
    <dbReference type="PaxDb" id="5476-C4YSV8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05653"/>
    <dbReference type="HOGENOM" id="CLU_058669_1_2_1"/>
    <dbReference type="OMA" id="IHQMAPW"/>
    <dbReference type="OrthoDB" id="5394411at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024624">
        <property type="entry name" value="Pyridox_Oxase_Alr4036_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243">
        <property type="entry name" value="AGL049CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE ALR4036 FAMILY FMN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12766">
        <property type="entry name" value="Pyridox_oxase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="228" mass="26850" checksum="58E302E58C228DF2" modified="2009-07-28" version="1">MIHQHFQPPWVAPFDESVKAELSVTKNDPPFTSFQLATIDSETGYPQNRTLVYRGWLFDNKDSSVLTFATDKRMSKYKELLHNDKCEAVFYFSRIKKQFRLRARARVIDEQNPPLDLINVLNQEEETERQISTDITQELNRQWSNLSKSLKKSFKKPPPKSVMSDENAKLISSIHRGVDGKNIDYGLKNFALVGLFIDYVDYYDLEKDKRFIYQLDENHQWFEQEVCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT26</accession>
    <name>C4YT26_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G2/mitotic-specific cyclin-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_05724</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT26"/>
    <dbReference type="SMR" id="C4YT26"/>
    <dbReference type="PaxDb" id="5476-C4YT26"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05724"/>
    <dbReference type="HOGENOM" id="CLU_020695_12_0_1"/>
    <dbReference type="OMA" id="ENIMHEY"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="269"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="362"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="366"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ47162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="486" mass="57249" checksum="1743090E4312FFA7" modified="2010-10-05" version="1">MRSYKSSITDENELTKQRLRAKSIANLSSNHTTAGQPSTSSQHREALTDLTSQENKNHPRVKLTQTNTNHHRNSSSSSNKIQIYQQIEQKKTDIHQFKKPRLEKVLLNDDDDETDDEFDDEEDKENRYHDLELNEDDSKHQLISEAFETIDDRGISEGENDTAQEARERLEEETQSHTQDMRSIYGVHVPMQPMWNNAIINELKYVIQKYSRNTLDENDEDTYDTTMVAEYSPEIFNYLHELENKFTPDPNYMDFQDDLKWEMRAVLIDWVVQVHARFNLFSETLYLTVNYIDRFLSKRRVSLSRFQLVGAVALFIAAKYEEINCPTVQEIAYMADNAYSIDEFLKAERFMIDVLEFDLGWPGPMSFLRRISKADDYDYETRTLAKYFLEITIMDSKFVASPPSWLAAGAHYISRILLGRGEWTELHVFYSGYTEKQLQPLADVLLENCRHAEINHKAIFEKYKERRYRKSSLFVQEYFRHIMSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTC6</accession>
    <name>C4YTC6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="13">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAWG_05413</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="13"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTC6"/>
    <dbReference type="PaxDb" id="5476-C4YTC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05413"/>
    <dbReference type="HOGENOM" id="CLU_000524_5_1_1"/>
    <dbReference type="OMA" id="FFGVVHY"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000016">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13 20" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="17">
        <location>
            <begin position="31"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="191"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="463"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="19">
        <location>
            <begin position="569"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="14">
        <location>
            <begin position="676"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="15">
        <location>
            <begin position="1041"/>
            <end position="1161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEQ46867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1166" mass="131089" checksum="61B428BD64FC8256" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTH7</accession>
    <name>C4YTH7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTH7"/>
    <dbReference type="PaxDb" id="5476-C4YTH7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05470"/>
    <dbReference type="HOGENOM" id="CLU_023194_1_1_1"/>
    <dbReference type="OMA" id="VPDMTRW"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001242">
        <property type="entry name" value="Oxidoreductase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000081">
        <property type="entry name" value="Uncharacterized protein CaJ7.0133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF1">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="2">
        <location>
            <begin position="147"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="42056" checksum="DA035FE767C1AAFC" modified="2009-07-28" version="1">MIAPNLLQIIVVGAGLIGPRHALHVSNNPQTDLFAIIDPNPATTDVAETFNTLYFPSIESCMKYCDENSIPYPDGAIVCTPNYTHVSVSAELASYGIHLLVEKPIGSTPEDAKALKHYCEIKNVKVLVGHHRRFNPYILATKENLFKVGQIIAIQGSWMLSKPQEYFDISPWRKNTSTGGGVLLINLVHDLDLLQYMFGRIQRIYAELLSQQRTHEADEGAALTIKFESGVTGTFICSDNVVSPFNFESGTGENPTIPQNQGVSGIYRIFGSKGTLSMPDMKLYHQDKGVTSSWTNPINETVIESDLEKLPFDSQLEHFIDLIRGNVKEPWCSIDDGISALLCIDAVMKSIESDMPVKVQDIKSVSADYKKLGIDQGIFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTR9</accession>
    <name>C4YTR9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTR9"/>
    <dbReference type="ESTHER" id="canal-q5ah37">
        <property type="family name" value="Monoglyceridelipase_lysophospholip"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YTR9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05564"/>
    <dbReference type="HOGENOM" id="CLU_026209_5_0_1"/>
    <dbReference type="OMA" id="IVCIENS"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="36"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="290" mass="33021" checksum="8FEFE71CAD4A3D3F" modified="2010-10-05" version="1">MEKQPRSGPIQECLLSGGNCVFNTYMVNADSEVDFRGIFIFVHGWSEHILMYSDLAYFVASLGYDFFAFDLRESGKTRGPYTDVDCPIRDLDFVIEKSTTKYKSFNLIGHSMGGAIILDYLCKGKYRDMIDSVILSGPCVKLHDSIQPSPLKRMFVNIILYWFPGIRYWESKSISAYASVTTNEKKQLEMFNDKLCCPNGPLKIISDMYYRGKRLVETIPDISNKARILIFQSENDSIVDPSAVKSFFNDLSSTTKKIVCIENSGHALFLEKESTVELINKEIESFLKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTS7</accession>
    <name>C4YTS7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTS7"/>
    <dbReference type="PaxDb" id="5476-C4YTS7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05572"/>
    <dbReference type="HOGENOM" id="CLU_2090443_0_0_1"/>
    <dbReference type="OMA" id="NFFIMEC"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="117" mass="13977" checksum="083D18B999D9C062" modified="2009-07-28" version="1" fragment="single">MLPITFLQIYMSASNKLVSFFLRKIQYLQLKHRHIIHPLKIEWIALYEKKEKKQNNWPVCVYMYVCVINNHHTYIVLLFTLPPNHTSIIPLIITATNFFIMECLQSSLKEKKIQVKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTX5</accession>
    <name>C4YTX5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_05621</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTX5"/>
    <dbReference type="SMR" id="C4YTX5"/>
    <dbReference type="PaxDb" id="5476-C4YTX5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05621"/>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="OMA" id="WNYTAVW"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF4">
        <property type="entry name" value="AMIDASE C550.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="102"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="254"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ47066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="573" mass="63897" checksum="D5AAE5AEFDAD1881" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTY9</accession>
    <name>C4YTY9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_05637</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMP46 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTY9"/>
    <dbReference type="PaxDb" id="5476-C4YTY9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05637"/>
    <dbReference type="HOGENOM" id="CLU_108996_0_0_1"/>
    <dbReference type="OMA" id="TITIFHN"/>
    <dbReference type="OrthoDB" id="4044803at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012882">
        <property type="entry name" value="Fmp46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071:SF1">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07955">
        <property type="entry name" value="DUF1687"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ47080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="172" mass="19729" checksum="3C025F1C614F622A" modified="2010-10-05" version="1">MSLFRSLQNSPSTISIFHNSSIPLSNKLYDILEKAYDTQPEKPKHEFQIDLMKNKMPTYDQYKLIVDKYLKGSTSKTILHNCFPFLHDSKTELYNSKGNVVTVKGVEWANKTFSPAEYQMIYDTFNKLQESSDQSINTIASNVFQAPLVVDWDNDVIAGDEETLKAILSKYN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>P0CB64</accession>
    <accession>Q5APC6</accession>
    <name>GET2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Golgi to ER traffic protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">GET2</name>
        <name type="ORF">CAWG_00456</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Golgi to ER traffic (GET) complex, which is composed of GET1, GET2 and GET3. Within the complex, GET1 and GET2 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GET2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0CB64"/>
    <dbReference type="SMR" id="P0CB64"/>
    <dbReference type="PaxDb" id="5476-P0CB64"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00456"/>
    <dbReference type="HOGENOM" id="CLU_066477_0_0_1"/>
    <dbReference type="OMA" id="QYWDVLS"/>
    <dbReference type="OrthoDB" id="4097053at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03114">
        <property type="entry name" value="Get2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014802">
        <property type="entry name" value="GET2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028143">
        <property type="entry name" value="Get2/sif1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263:SF1">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08690">
        <property type="entry name" value="GET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0931">ER-Golgi transport</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000388625" description="Golgi to ER traffic protein 2">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="232"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="297"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="298" mass="33632" checksum="247A5AF2D45C5DDC" modified="2009-11-03" version="1">MSEPVVDTAELSAEEKKRLLRERRQAKMSKGKATARLNDILSQGSSVKTSGVKSVLDQEKEATPSHDEDPEIQDITEITTPPPRTPPIGEDAPQDIDKIFQSMLQQQGQGADTAGDPFAQIMKMFNQVEGGDSPPSESATSTQDPAELKYRQELLEYNTYNQKLWKFRFLLVRVSVTLFNFFYHYINLSNFHASNYAYVRDLSSEKYPVRDFFTWFATTEVVLVAAYYSIFHSLGLFHAANQNSFVLKAMSMGSMVLPQLEHYKPLVARFLGYYELLGIVLGDLSLVIVLFGLLSFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCS4</accession>
    <name>C4YCS4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA-splicing factor CWC2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAWG_00308</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM CWC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCS4"/>
    <dbReference type="SMR" id="C4YCS4"/>
    <dbReference type="PaxDb" id="5476-C4YCS4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00308"/>
    <dbReference type="HOGENOM" id="CLU_043308_0_1_1"/>
    <dbReference type="OMA" id="WYNKWSQ"/>
    <dbReference type="OrthoDB" id="10251848at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12360">
        <property type="entry name" value="RRM_cwf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034181">
        <property type="entry name" value="Cwc2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="9 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="19">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="18">
        <location>
            <begin position="141"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="16">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="246"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEQ42110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="363" mass="41272" checksum="4AFFBB5543523293" modified="2009-07-28" version="1">MSRKVSISSLTLSEPMTKPARVQVNPEDIDDLDKTQQVNNHQYNIWYSKSLSDANNKSTTKSKYRVRISTDQGFTKANKNTHICLFFSRGCCYLGSKCQYFHRLPKESDNFKPTQDCFGRDKTANYRDDMDGVGSLNKVNCTLYVGGIHIKPNTEQLLVKNFQEFGTVEKVRVLQGKGCAFVTMKTENQAQFAKEAMQSQSLVEGSNEVLYVRWANEDKNPAAQKQEKKRQQELAYDTVKQLLEQESNKKPRLENGAVNRIETINIDDESEDEGAVEDDEADDDIEETRVNSLSAGVKKNVSTHQANGTPESSSTSDENDHNTILRNSLLKDISRLKKKMVYKREEPYLTNLLVDYSSDEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCV2</accession>
    <name>C4YCV2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCV2"/>
    <dbReference type="PaxDb" id="5476-C4YCV2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00336"/>
    <dbReference type="HOGENOM" id="CLU_1517670_0_0_1"/>
    <dbReference type="OrthoDB" id="4023212at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="177" mass="19774" checksum="220F496D405C656C" modified="2010-10-05" version="1">MVSRKSSSSSNKTSTSTDTMIETIGKPQTVNTSYTSSHDFIPSRPPPPPKIGSASEDTEENTSSSQSSKVSKQDKLQEFSKKLFKKTSSSSLNKKTFYQKLRGKEKKKQRIHGTGVDKNIQTDDITNSLTLDMLDVKKKREKKYRENVTSSLKTFLDSNTSNGAVDSFKDYVENSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD01</accession>
    <name>C4YD01_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">low-specificity L-threonine aldolase</fullName>
            <ecNumber evidence="8">4.1.2.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_00388</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-allo-threonine = acetaldehyde + glycine</text>
            <dbReference type="Rhea" id="RHEA:26209"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58585"/>
            <dbReference type="EC" id="4.1.2.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-threonine = acetaldehyde + glycine</text>
            <dbReference type="Rhea" id="RHEA:19625"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.1.2.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid degradation; L-threonine degradation via aldolase pathway; acetaldehyde and glycine from L-threonine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.48" evidence="8"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD01"/>
    <dbReference type="SMR" id="C4YD01"/>
    <dbReference type="PaxDb" id="5476-C4YD01"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00388"/>
    <dbReference type="HOGENOM" id="CLU_029381_1_0_1"/>
    <dbReference type="OMA" id="LVRIKAW"/>
    <dbReference type="OrthoDB" id="10261951at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06502">
        <property type="entry name" value="TA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000030">
        <property type="entry name" value="Low-specificity L-threonine aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041359">
        <property type="entry name" value="GntG_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="11">
        <location>
            <begin position="14"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00050410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ42187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="373" mass="41778" checksum="C0F741E6F2DD3187" modified="2010-10-05" version="1">MTADEEETFTTFNEFRSDTFTVPTRAMVEDGFMNATFGDSVYQEDETTLRLESKMCEITGKPAALFCVSGTMSNQIGLRANLVQPPYSILCDYRAHVFLHEAGGLATLSQAMVHPVRPSNGNYLTFEDVLANVTYDDGDIHAAPTKVISLENTLHGIIIPIEEIRKISEFCRENDIRLHLDGARLWNASVATGISIKEYCSYFDSVSLCLSKSLGAPIGSVLVGDEKFIRKANHFKKQSGGGIRQAGIMSAMAIHAIDYNLSKLELSHNYAKQIGDFCQEHGIKLESPVDTSLVFLDLKANKMDPNRLVELGRTKYNVKLMGQRIACHFQLSQESVDNVKKCILECFEYHQKHPHKDDGRNNKKMYSFDAIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD25</accession>
    <name>C4YD25_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein HOL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_00413</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD25"/>
    <dbReference type="PaxDb" id="5476-C4YD25"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00413"/>
    <dbReference type="HOGENOM" id="CLU_008455_13_3_1"/>
    <dbReference type="OMA" id="WGMQNIA"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF34">
        <property type="entry name" value="PROTEIN HOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="538"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ42211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="584" mass="65266" checksum="FBC1271DF52218D3" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDE3</accession>
    <name>C4YDE3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_00536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDE3"/>
    <dbReference type="PaxDb" id="5476-C4YDE3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00536"/>
    <dbReference type="HOGENOM" id="CLU_022899_0_0_1"/>
    <dbReference type="OMA" id="QRLVILW"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840:SF1">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="477"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="536"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ42329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="554" mass="62114" checksum="F9E8497C993E3EDE" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDH1</accession>
    <name>C4YDH1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GCD complex subunit GCD6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Guanine nucleotide exchange factor subunit GCD6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_00566</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
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        <property type="protein sequence ID" value="EEQ42357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDH1"/>
    <dbReference type="PaxDb" id="5476-C4YDH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00566"/>
    <dbReference type="HOGENOM" id="CLU_012507_1_0_1"/>
    <dbReference type="OMA" id="LAQSCKI"/>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04197">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05787">
        <property type="entry name" value="LbH_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11558">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000022">
        <property type="entry name" value="Translation initiation factor eIF-2B epsilon subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000066">
        <property type="entry name" value="Translation initiation factor eIF-2B subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000042">
        <property type="entry name" value="Translation initiation factor eIF2B subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035543">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044123">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="11">
        <location>
            <begin position="559"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ42357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="732" mass="81925" checksum="A9070FDA77F16358" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDH3</accession>
    <name>C4YDH3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_00568</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDH3"/>
    <dbReference type="PaxDb" id="5476-C4YDH3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00568"/>
    <dbReference type="HOGENOM" id="CLU_008721_4_2_1"/>
    <dbReference type="OMA" id="AVMITCN"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000021">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00846">
        <property type="entry name" value="caca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="58"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="268"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ42359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="416" mass="44531" checksum="1324D58200D57965" modified="2009-07-28" version="1">MSDLPLLGGSRNQGNFMHRAKKSVYNGTLSTLKSSPVNYLLIFVPLGIIAGELEWSATARFLLNFFAIVPLASVLAFATEEISEHVGQTVGGLLNATFGNAVELIVSIIALKDNQVRIVQASMLGSILSNLLLVLGCCFVAGGITRVQQTFNQTVAQTMSSLMALATASLLIPAAFHASLPTPKKGGGFPEPGSSDELILSFSRGVSVVLLIVYLFYLLFSLKTHKELFEEDQSADAILNERSQNSTLDVVTGPKAEEDGHLSMTAGLVVLLLTTILVSFCADYLVGSIDEIVESSGLSKTFIGLIVIPIVGNAAEHVTAIVVAMKDKMDLAIGVAIGSSLQIAIFVTPFMVLVGWAIDVPMSLYFSTFETAILFVSVFITNLVILDGESNWLEGAMLLSTYLIIALAFFYYPDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDQ1</accession>
    <name>C4YDQ1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_00648</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDQ1"/>
    <dbReference type="PaxDb" id="5476-C4YDQ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00648"/>
    <dbReference type="HOGENOM" id="CLU_009614_0_0_1"/>
    <dbReference type="OMA" id="AENEFLM"/>
    <dbReference type="OrthoDB" id="3268246at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="25"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ42437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1040" mass="118575" checksum="A643A221D15EC083" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDY6</accession>
    <name>C4YDY6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_00735</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
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        <source>
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    <sequence length="800" mass="86608" checksum="D81A88835A4C4E12" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C4YE07</accession>
    <name>C4YE07_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Glutamate synthase [NADH]</fullName>
            <ecNumber evidence="19">1.4.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">CAWG_00757</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="26 27">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Forms L-glutamate from L-glutamine and 2-oxoglutarate. Represents an alternative pathway to L-glutamate dehydrogenase for the biosynthesis of L-glutamate. Participates with glutamine synthetase in ammonia assimilation processes. The enzyme is specific for NADH, L-glutamine and 2-oxoglutarate.</text>
    </comment>
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        <reaction evidence="20">
            <text>2 L-glutamate + NAD(+) = L-glutamine + 2-oxoglutarate + NADH + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="1.4.1.14"/>
        </reaction>
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        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
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        <cofactor evidence="1">
            <name>FMN</name>
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    </comment>
    <comment type="cofactor">
        <cofactor evidence="24">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="24">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Energy metabolism; nitrogen metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glutamate synthase family.</text>
    </comment>
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        <property type="entry name" value="Glutamate_Synthase"/>
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        <property type="entry name" value="Helical_ferredxn"/>
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        <property type="entry name" value="Ntn_hydrolases_N"/>
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    <dbReference type="NCBIfam" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PRK11750.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
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        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
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        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="Alpha subunit of glutamate synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18 24" id="KW-0003">3Fe-4S</keyword>
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    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0288">FMN</keyword>
    <keyword evidence="17" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="13" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="16 24" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="25">
        <location>
            <begin position="50"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="23">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1180"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1186"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1191"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00057049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00068518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="EEQ42543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="2126" mass="235453" checksum="ABEF0F89DF3FE314" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEA8</accession>
    <name>C4YEA8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Telomere-associated protein Rif1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_00863</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00863"/>
    <dbReference type="HOGENOM" id="CLU_003622_0_0_1"/>
    <dbReference type="OMA" id="AMDIWVA"/>
    <dbReference type="OrthoDB" id="4070686at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14267">
        <property type="entry name" value="Rif1_CTD_C-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022031">
        <property type="entry name" value="Rif1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22928">
        <property type="entry name" value="TELOMERE-ASSOCIATED PROTEIN RIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22928:SF3">
        <property type="entry name" value="TELOMERE-ASSOCIATED PROTEIN RIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12231">
        <property type="entry name" value="Rif1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0779">Telomere</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Telomere-associated protein Rif1 N-terminal" evidence="9">
        <location>
            <begin position="390"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1207"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1366"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1543"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1208"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1222"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1252"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1405"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1543"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1561"/>
            <end position="1571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ42644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1665" mass="188674" checksum="5E68432367000AF4" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEC2</accession>
    <name>C4YEC2_CANAW</name>
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        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_00877</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEC2"/>
    <dbReference type="SMR" id="C4YEC2"/>
    <dbReference type="PaxDb" id="5476-C4YEC2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00877"/>
    <dbReference type="HOGENOM" id="CLU_073901_1_1_1"/>
    <dbReference type="OMA" id="LGPTLWW"/>
    <dbReference type="OrthoDB" id="10256606at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04330">
        <property type="entry name" value="RNAP_III_Rpc25_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000221">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004519">
        <property type="entry name" value="RNAP_E/RPC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00448">
        <property type="entry name" value="rpoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="7">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="8">
        <location>
            <begin position="83"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ42658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="195" mass="22763" checksum="C79214897DE9DCE8" modified="2010-10-05" version="1">MFILSEISDLIRIPPSAFNVPIQHSISDELNKKYANKIIANLGLVITIWDILDIKDGLLKPGDGGSYVEVRFRSIVWKPFRGEILTGWVTECTAKGIKVRMEFFDEIWIPKDFLFENCKYSESEQAWIYLLDENELFIDVNEKIRFRVEEENFYNVKPKLEDEQTEEEKKATTLPPYTITASCQDYGMGCVSWWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEI4</accession>
    <name>C4YEI4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">tRNA (uracil-O(2)-)-methyltransferase</fullName>
            <ecNumber evidence="3 11">2.1.1.211</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_00941</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10339"/>
            <dbReference type="Rhea" id="RHEA-COMP:10340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.211"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TRM44 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.211" evidence="3 11"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEI4"/>
    <dbReference type="PaxDb" id="5476-C4YEI4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00941"/>
    <dbReference type="HOGENOM" id="CLU_018580_2_0_1"/>
    <dbReference type="OMA" id="IREPNIN"/>
    <dbReference type="OrthoDB" id="10047021at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141101">
        <property type="term" value="F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011671">
        <property type="entry name" value="tRNA_uracil_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210:SF0">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07757">
        <property type="entry name" value="AdoMet_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 11" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ42720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="519" mass="59490" checksum="293204FFBE9F4432" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEJ3</accession>
    <name>C4YEJ3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_00950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEJ3"/>
    <dbReference type="PaxDb" id="5476-C4YEJ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00950"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_11_1"/>
    <dbReference type="OMA" id="SHVDEWR"/>
    <dbReference type="OrthoDB" id="153074at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05367">
        <property type="entry name" value="SPR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000281">
        <property type="entry name" value="Uncharacterized oxidoreductase YIR035C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF8">
        <property type="entry name" value="BENZIL REDUCTASE ((S)-BENZOIN FORMING) IRC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="3"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ42729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="253" mass="27387" checksum="E439F2B67C125408" modified="2009-07-28" version="1">MSHVSIITGASRGIGKAIAEVLLKDPNTKVVVVARTEAPLEALANKYGSDRVDFVVGDITDSSTSEKAVESAISKFGQLNSIIANAGVLEPVGPIESTSVDDWKRLYDINLFAVVELIKHSLPHLKKTNGKVIAVSSGAATKAYSGWYAYGSSKAALNHLILSLASDEKDVQAISIAPGVVDTEMQTDIREKFGKNMTPEGLQRFVDLHENRQLASPEEPGTVYAKLALQGWSKDLNGKFLRYNDEILKAYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEJ8</accession>
    <name>C4YEJ8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_00955</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEJ8"/>
    <dbReference type="PaxDb" id="5476-C4YEJ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00955"/>
    <dbReference type="HOGENOM" id="CLU_011608_3_0_1"/>
    <dbReference type="OMA" id="FTHRHAL"/>
    <dbReference type="OrthoDB" id="267048at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12677">
        <property type="entry name" value="RRM4_Nop4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001523">
        <property type="entry name" value="mRNA-binding ribosome biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000704">
        <property type="entry name" value="Ribosome biogenesis (Nop4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034809">
        <property type="entry name" value="Nop4_RRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="33"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="135"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="309"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="481"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="218"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="644"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="644"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="688"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="707"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="730"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ42734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="741" mass="84091" checksum="AB15314217F01DB7" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C4YES9</accession>
    <name>C4YES9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADP-ribosylation factor GTPase-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_01037</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase-activating protein for the ADP ribosylation factor family.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YES9"/>
    <dbReference type="PaxDb" id="5476-C4YES9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01037"/>
    <dbReference type="HOGENOM" id="CLU_316862_0_0_1"/>
    <dbReference type="OMA" id="QFRQMIE"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07608">
        <property type="entry name" value="BAR_ArfGAP_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF160">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN EFFECTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="560"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="716"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ42815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="958" mass="111161" checksum="16A21E15501E0580" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEX6</accession>
    <name>C4YEX6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="9">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Exo-1,3-beta-glucanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_01085</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="9"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEX6"/>
    <dbReference type="SMR" id="C4YEX6"/>
    <dbReference type="PaxDb" id="5476-C4YEX6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01085"/>
    <dbReference type="HOGENOM" id="CLU_004624_0_1_1"/>
    <dbReference type="OMA" id="MDYHEYQ"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000033">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF1">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE I_II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946405" description="Glucan 1,3-beta-glucosidase" evidence="13">
        <location>
            <begin position="22"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="14">
        <location>
            <begin position="99"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ42862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="438" mass="50056" checksum="6FEAEA80C1B0121C" modified="2010-10-05" version="1">MQLSFILTSSVFILLLEFVKASVISNPFKPNGNLKFKRGGGHNVAWDYDNNVIRGVNLGGWFVLEPYMTPSLFEPFQNGNDQSGVPVDEYHWTQTLGKEAASRILQKHWSTWITEQDFKQISNLGLNFVRIPIGYWAFQLLDNDPYVQGQVQYLEKALGWARKNNIRVWIDLHGAPGSQNGFDNSGLRDSYNFQNGDNTQVTLNVLNTIFKKYGGNEYSDVVIGIELLNEPLGPVLNMDKLKQFFLDGYNSLRQTGSVTPVIIHDAFQVFGYWNNFLTVAEGQWNVVVDHHHYQVFSGGELSRNINDHISVACNWGWDAKKESHWNVAGEWSAALTDCAKWLNGVNRGARYEGAYDNAPYIGSCQPMLDISQWSDEHKTDTRRYIEAQLDAFEYTGGWVFWSWKTENAPEWSFQTLTYNGLFPQPVTDRQFPNQCGFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEZ4</accession>
    <name>C4YEZ4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="19">DNA repair protein RAD16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAWG_01103</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEZ4"/>
    <dbReference type="PaxDb" id="5476-C4YEZ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01103"/>
    <dbReference type="HOGENOM" id="CLU_000315_2_1_1"/>
    <dbReference type="OMA" id="DHIMLRR"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000109">
        <property type="term" value="C:nucleotide-excision repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16567">
        <property type="entry name" value="RING-HC_RAD16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000753">
        <property type="entry name" value="DNA repair protein RAD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001864">
        <property type="entry name" value="DNA repair protein RAD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="253"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="596"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="685"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEQ42880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="852" mass="97328" checksum="11A3A3621CE0CF87" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFC5</accession>
    <name>C4YFC5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase eIF4A</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Eukaryotic initiation factor 4A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAWG_01241</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFC5"/>
    <dbReference type="SMR" id="C4YFC5"/>
    <dbReference type="PaxDb" id="5476-C4YFC5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01241"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="OMA" id="FGCQALV"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Eukaryotic initiation factor 4A-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 19" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="54"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="235"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEQ43011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="397" mass="44599" checksum="A81935EA752DDD60" modified="2009-07-28" version="1">MASEGITEIDSGLIETNYDNVVYKFDDLNLKPNIVRGIFGYGYETPSAIQQRAILPITEGRDVLAQAQSGTGKTATFTISALQRINENEKATQALILAPTRELALQIKNVITAIGLYLKVTVHASIGGTSMSDDIEAFRSGVQIVVGTPGRVLDMIERRYFKTDKVKMFILDEADEMLSSGFKEQIYNIFRLLPETTQIVLLSATMPQDVLEVTTKFMNNPVRILVKKDELTLEGIKQFYINVELEDYKFDCLCDLYDSISVTQAVIFCNTRSKVEFLTNKLREQHFTVSAIHADLPQAERDTIMKEFRSGSSRILISTDLLARGIDVQQVSLVINYDLPANKENYIHRIGRGGRFGRKGVAINFVTDRDVGMMREIEKFYSTQIEEMPADIGALFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG05</accession>
    <name>C4YG05_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_00118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="SMR" id="C4YG05"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00118"/>
    <dbReference type="HOGENOM" id="CLU_035248_0_0_1"/>
    <dbReference type="OMA" id="MSHEEDY"/>
    <dbReference type="OrthoDB" id="16547at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014842">
        <property type="entry name" value="AFT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13681">
        <property type="entry name" value="SURVIVAL OF MOTOR NEURON-RELATED-SPLICING FACTOR 30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13681:SF24">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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        </location>
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            <end position="490"/>
        </location>
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        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
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        <location>
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            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ41929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="573" mass="64026" checksum="C07427C302F29102" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG72</accession>
    <name>C4YG72_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trafficking protein particle complex III-specific subunit 85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YG72"/>
    <dbReference type="PaxDb" id="5476-C4YG72"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00190"/>
    <dbReference type="HOGENOM" id="CLU_028342_0_0_1"/>
    <dbReference type="OMA" id="YGNNAKY"/>
    <dbReference type="OrthoDB" id="203724at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ41996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="757" mass="88028" checksum="CF29FD480D374567" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGE6</accession>
    <name>C4YGE6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_03122</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YGE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03122"/>
    <dbReference type="HOGENOM" id="CLU_000487_3_0_1"/>
    <dbReference type="OMA" id="AVCPPYN"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="RNA polymerase II, clamp domain"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RNA_pol_asu"/>
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        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
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        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
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        <property type="entry name" value="RNAP_III_Rpc1_C"/>
    </dbReference>
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        <property type="entry name" value="RNAP_III_RPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
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        <property type="entry name" value="RPC1"/>
    </dbReference>
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        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14 16" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="15">
        <location>
            <begin position="253"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEQ44828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1448" mass="161516" checksum="623D4CB15A5469BB" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGS6</accession>
    <name>C4YGS6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="4 12">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">5-proFAR isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_03258</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="4 12"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGS6"/>
    <dbReference type="SMR" id="C4YGS6"/>
    <dbReference type="PaxDb" id="5476-C4YGS6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03258"/>
    <dbReference type="HOGENOM" id="CLU_065050_0_0_1"/>
    <dbReference type="OMA" id="IEWNKTH"/>
    <dbReference type="OrthoDB" id="446074at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04723">
        <property type="entry name" value="HisA_HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000110">
        <property type="entry name" value="1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011858">
        <property type="entry name" value="His6/HISN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02129">
        <property type="entry name" value="hisA_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090:SF2">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ44958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="279" mass="30824" checksum="D796F68A246C3959" modified="2009-07-28" version="1">MTKFRGCIDIHSGQVKQIVGGTLTQDDSASSETSSTKENFVSTKPSSHYAQLYKDYNVKGCHVIKLGSNPANDDAAKLALSTWPHNLQVGGGINLDNAQYWLDQGASHVILTSWLFTKNEQDKMELDFGKLREINKLIGKEKLIVDLSCRTVIENGKTNWYVAMNKWQTITDTILSAEFLLKVSAYCDEFLIHAADVEGLCKGIDEKLVENLGEWCPVGFEEKIVYAGGAKSINDLDTVAKLSKGKVDLTYGSSLDIFGGKLVNFTDLVEWNKANSKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGT1</accession>
    <name>C4YGT1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fmp27p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_03263</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YGT1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03263"/>
    <dbReference type="HOGENOM" id="CLU_000741_0_0_1"/>
    <dbReference type="OMA" id="IQLKWNN"/>
    <dbReference type="OrthoDB" id="1562405at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019441">
        <property type="entry name" value="FMP27/BLTP2/Hobbit_GFWDK_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019415">
        <property type="entry name" value="FMP27_SW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019449">
        <property type="entry name" value="FMP27_WPPW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01214">
        <property type="entry name" value="Fmp27_GFWDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01215">
        <property type="entry name" value="Fmp27_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01216">
        <property type="entry name" value="Fmp27_WPPW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 SW motif-containing RBG unit" evidence="5">
        <location>
            <begin position="1122"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit" evidence="4">
        <location>
            <begin position="1239"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 WPPW motif-containing RBG unit" evidence="6">
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            <begin position="1635"/>
            <end position="2132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1042"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="1881"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2452"/>
            <end position="2514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="2735"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1810"/>
            <end position="1866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1065"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2452"/>
            <end position="2476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="2477"/>
            <end position="2488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2489"/>
            <end position="2514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2669"/>
            <end position="2683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="2684"/>
            <end position="2694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2705"/>
            <end position="2716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2722"/>
            <end position="2735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ44963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2735" mass="314485" checksum="34ABA430F5012BEC" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHL5</accession>
    <name>C4YHL5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bem3p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_03563</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="PaxDb" id="5476-C4YHL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03563"/>
    <dbReference type="HOGENOM" id="CLU_006138_1_0_1"/>
    <dbReference type="OMA" id="MANIHIK"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005933">
        <property type="term" value="C:cellular bud"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04400">
        <property type="entry name" value="RhoGAP_fBEM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000141">
        <property type="entry name" value="Rho GTPase-activating protein (RhoGAP), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
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        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="644"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="943"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="416"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="755"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="828"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="195"/>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
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            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Sakthikumar S."/>
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                <person name="Rheinbay E."/>
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                <person name="Forche A."/>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
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    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_03681</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHX7"/>
    <dbReference type="PaxDb" id="5476-C4YHX7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03681"/>
    <dbReference type="HOGENOM" id="CLU_020088_4_2_1"/>
    <dbReference type="OMA" id="YEYYPRT"/>
    <dbReference type="OrthoDB" id="409173at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037982">
        <property type="entry name" value="Nramp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF101">
        <property type="entry name" value="MANGANESE TRANSPORTER SMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ45359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="577" mass="63144" checksum="20EBC9AF0A6F2439" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHZ4</accession>
    <name>C4YHZ4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">QRI7</name>
        <name evidence="9" type="ORF">CAWG_03700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHZ4"/>
    <dbReference type="PaxDb" id="5476-C4YHZ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03700"/>
    <dbReference type="HOGENOM" id="CLU_023208_4_1_1"/>
    <dbReference type="OMA" id="NAAMIGC"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072670">
        <property type="term" value="P:mitochondrial tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000377">
        <property type="entry name" value="tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="8">
        <location>
            <begin position="63"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ45376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="450" mass="50553" checksum="9DCEFA62EF81B091" modified="2009-07-28" version="1">MISNTFKIRCPLPLKRISSTSIRTYRVMAIESSCDDSCVALLEKSHPKTPPKIIDQFKRTLHSADVGGILPTAAYNYHMATIAIMVQEFCHKHQISALNPPDLLCVTRGPGMAGSLSTSTEFAKGLSVAWDVPLVGVHHMLGHLLTANLPNSEQPKLPPPNYPFLSLLCSGGHTMLVLSKSLTEHEIIVNVGDIAVGDSLDKCARELGMYGNMLGKELEKYINSIPEETRNQYEKLSVNTRIANPYNFRLTLPYSAPKYGIPGDVKFAFSHFLSNIQEYKAMHYNKNRGEGESEGEGEIDLTLDEETKQFIAYKTQEFIFDHIVDRINIAFKKHGIKNRNSDGTFIGVKDFICSGGVAANNRLRQKLREKLDFQEIGTDNVNVNFHFPDLSLCTDNAIMIGAAGIEIFEKLRLRTDLSFLPIRKWPLNKLLDVDGWVKVEEEEFNRICKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI37</accession>
    <name>C4YI37_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_03745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YI37"/>
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    <dbReference type="OrthoDB" id="5286008at2759"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045290">
        <property type="term" value="F:D-arabinose 1-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070485">
        <property type="term" value="P:dehydro-D-arabinono-1,4-lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19164">
        <property type="entry name" value="AKR_ARA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000041">
        <property type="entry name" value="D-arabinose 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044480">
        <property type="entry name" value="Ara2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686:SF1">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ45419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="327" mass="36925" checksum="3325E8AD52CF759D" modified="2009-07-28" version="1">MLQPIGKPEVLDPYSIKNLPPLIIGGAVFNYQYSSDPHSLPVQELIERAFQLGLNALDTSPYYGPSEEIIGQALQKISFSRDQYYICTKAGRVQLDEFDYSRASVRSSVERSLQRLGTSYIDLVYMHDIEFVEPDQIMDALKELHLLKSEGLIKNFGISGYPVKFLYEIALRCKNEIAPLDAVLSYCNGCIQNTLLFEYHDKFLQDCGVQTVLNGSILSMSMLRSDITHSFHPASPALKQRVADIAEKLKEENVELADLATRFAIKEWLFKYKSGIVLGVSNLHELESAVQCYWDVKSGVFNDGKLVEQVQTSLAEHFNETWPSGNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI51</accession>
    <name>C4YI51_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_03759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI51"/>
    <dbReference type="PaxDb" id="5476-C4YI51"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03759"/>
    <dbReference type="HOGENOM" id="CLU_1503249_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ45433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="179" mass="18471" checksum="80AE827BE1E738AF" modified="2009-07-28" version="1">MLAASSTPLAIALLNPRSSMVNKPPIVVPPGVHTLLFNAAGCSPVSKTIRAVPSITLAAATDATSYGIPILTAPSIMDSIINKQKAGPDPINEVAMSMFFSGIFTVIPTVSINFITNSWLSSLTSGANAIAAVPQPNSAGVLVMTLATYGVKIDNSFIVVPANNEINNCFPVNDSLTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI84</accession>
    <name>C4YI84_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_04156</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI84"/>
    <dbReference type="PaxDb" id="5476-C4YI84"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04156"/>
    <dbReference type="HOGENOM" id="CLU_479935_0_0_1"/>
    <dbReference type="OMA" id="WQDNRYI"/>
    <dbReference type="OrthoDB" id="5310959at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019680">
        <property type="entry name" value="Mediator_Med1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041:SF4">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10744">
        <property type="entry name" value="Med1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med1" evidence="9">
        <location>
            <begin position="9"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ45819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="618" mass="69751" checksum="56CFA407D87F33D5" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIF5</accession>
    <name>C4YIF5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIF5"/>
    <dbReference type="PaxDb" id="5476-C4YIF5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04228"/>
    <dbReference type="HOGENOM" id="CLU_016174_1_1_1"/>
    <dbReference type="OMA" id="CQRFRIT"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47186">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47186:SF3">
        <property type="entry name" value="OS09G0267800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="654"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="673" mass="76421" checksum="D4656B53A0898535" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIP8</accession>
    <name>C4YIP8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="8">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_04324</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="8"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIP8"/>
    <dbReference type="SMR" id="C4YIP8"/>
    <dbReference type="PaxDb" id="5476-C4YIP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04324"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="OMA" id="VGTMYFM"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000687">
        <property type="entry name" value="MAP kinase kinase MKK1/SSP32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF6">
        <property type="entry name" value="MAP KINASE KINASE MKK1_SSP32-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="158"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="70"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ45983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="446" mass="50295" checksum="BC21F5F8417ADC0D" modified="2010-10-05" version="1">MASVPPLFKVPNTKRTSNNKVLPNLSIPPTSNNKNGNPNTKPSLSLNQNIINHDSQQHENLNPLSYQPHQLQHQQYQNPQGLKLSTSPSSVSSSKSTKRKPPPIDTKVISHSPDMMDVDQQGSADESVNVDENEYSVKHHLEQLTPYDWHLIANANKIVEISSLGEGNGGAVTKCYIPQLPNKQIFALKLVMCDPNPDLQKQIFRELEVAKKCQHPNIVKYYGTFLLEKQSMIGIAMEFMDGQSLDSIYKEVLKRDKTNRINEKVLGKIANSILSGLDYLHSKNIIHRDIKPSNILLDTKGNVKLCDFGVSGEAVNSFASTFVGTQYYMAPERITGGNYSITSDIWSLGMSLLEVANGCFPIIQSLGPIEVVEIISRSNLELKDCEEDNIFWTREFKQFIAKCLTKDYLRRPKPSDLLAHDEWCLIQSKEKVKMDKFVKVVWELNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIT9</accession>
    <name>C4YIT9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Small nuclear ribonucleoprotein Sm D2</fullName>
            <shortName evidence="12">Sm-D2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 12">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_04367</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ46024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIT9"/>
    <dbReference type="SMR" id="C4YIT9"/>
    <dbReference type="PaxDb" id="5476-C4YIT9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04367"/>
    <dbReference type="HOGENOM" id="CLU_076902_2_1_1"/>
    <dbReference type="OMA" id="DVKEMWT"/>
    <dbReference type="OrthoDB" id="437526at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000018">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 14" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="30"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ46024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="112" mass="13008" checksum="2AA7A38E1C46F9AD" modified="2009-07-28" version="1">MSELIDRPRSELTELELKTLEEYEFNHGPMSILNNAVKNDSPIIISCRNNHKLIGKVRAFDRHCNLVLENVKELWTEDIKNNKGKKIKSISKERFISKMFLRGDSVIIILKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJM8</accession>
    <name>C4YJM8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxidant-induced cell-cycle arrest protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_04046</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the BUB2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OCA5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJM8"/>
    <dbReference type="PaxDb" id="5476-C4YJM8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04046"/>
    <dbReference type="HOGENOM" id="CLU_029367_2_1_1"/>
    <dbReference type="OMA" id="CHKSEPQ"/>
    <dbReference type="OrthoDB" id="10263206at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990334">
        <property type="term" value="C:Bfa1-Bub2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031030">
        <property type="term" value="P:negative regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000035">
        <property type="entry name" value="Cell cycle arrest protein BUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000026">
        <property type="entry name" value="Mitotic check point protein (Bub2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF263">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="8">
        <location>
            <begin position="48"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ45712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="314" mass="35978" checksum="FD535068F7C3A924" modified="2009-07-28" version="1">MEQELLLKGRKKDSIEQFISGSQLFLENGLSQLRYMVLVEGLSTPEGYDQCPYRSYVWSILCRVPPFPTEQYLQLLETSSQTLPDELLIKIKNDTFRTLMNDKKFHSKVNEESLIRILSCIGITTEVGYVQGLNVLLAPIAYVCHKSEPQAFAILHNLITKQIPLYITPNMEGVHTGLQLVDAVLKIIDPVLSEYLDSKFLKAKIYAFPSILTLCACTPPLKSVLKLWDFLFAYGTHINVLFVVAQLIICRSSILESEQPMKILRTWPNLEENEIIKLSLSFIPELPEKLYDLIARHGYDRKVPKELARFLEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJP0</accession>
    <name>C4YJP0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJP0"/>
    <dbReference type="PaxDb" id="5476-C4YJP0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04058"/>
    <dbReference type="HOGENOM" id="CLU_158090_0_0_1"/>
    <dbReference type="OMA" id="SWCGLKL"/>
    <dbReference type="OrthoDB" id="2157498at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029164">
        <property type="entry name" value="PIG-Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400:SF1">
        <property type="entry name" value="PIG-P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400">
        <property type="entry name" value="YALI0E29227P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15159">
        <property type="entry name" value="PIG-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="116" mass="13625" checksum="08B0781CF508202F" modified="2009-07-28" version="1">MRSQSLPLPLIESPDSIDLDPINHENLAVYGYLLLISTWMLFIISINSIFEIWRFIIQPLQSSPTSLLLYDKLTIFFETIDSYIIKLWCIYVVCWWWAIVSWSGLKLFRHSKGIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJS2</accession>
    <name>C4YJS2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_04092</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJS2"/>
    <dbReference type="PaxDb" id="5476-C4YJS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04092"/>
    <dbReference type="HOGENOM" id="CLU_009020_1_1_1"/>
    <dbReference type="OMA" id="FAFTGHQ"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF224">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="10"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ45756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="440" mass="48061" checksum="B593AD342567506E" modified="2010-10-05" version="1">MPSIDNDAGASTVSSSISLVKTIIGAGLLSMPLAYSTDGIIFGTFIILLAAFTSGFGLFLQCYVSRYVPVKHATFFNLCSITYPHLSVVFDFAIAVQCFGCAVSYLVLIRDLMPTIVTYVPYIDEKHYPSFWLLVSTVLTIPLSFLKNLDSLKYSSILGLVAIFYMTILVIGHYFAGDIERQGQITLFPTSVTGVFSTFSIIVFAFTGHQNMFSIINEARDKSLTSLTKLVNFAIGISSLLFIAVGLSGYLTFGQDVDGNVILSYPNGLTTTIGRFCIVFMVTFSFPLMIHPARISINNIYHWVTTNYFDKDEANESTALLGNESQESQIAEDEEQGKTHLSHVVPFPHKHFVIVTTSLLIIGYLLAISIKSFALILAIVGASGSTSISFILPGLFGYKLIGSESDDPSTLEVAFKNLSLGLTFWGVAVMILCLYSSLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJV6</accession>
    <name>C4YJV6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_04126</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJV6"/>
    <dbReference type="PaxDb" id="5476-C4YJV6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04126"/>
    <dbReference type="HOGENOM" id="CLU_006937_7_0_1"/>
    <dbReference type="OMA" id="ARSKHWI"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000214">
        <property type="entry name" value="PROBABLE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF5">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ45790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="63060" checksum="1139FE9C6D82129F" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK02</accession>
    <name>C4YK02_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spermidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_05794</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK02"/>
    <dbReference type="SMR" id="C4YK02"/>
    <dbReference type="PaxDb" id="5476-C4YK02"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05794"/>
    <dbReference type="HOGENOM" id="CLU_048199_1_0_1"/>
    <dbReference type="OMA" id="FLYHEMM"/>
    <dbReference type="OrthoDB" id="38125at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.140.10:FF:000001">
        <property type="entry name" value="SPE3p Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000013">
        <property type="entry name" value="Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030668">
        <property type="entry name" value="Spermi_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002010">
        <property type="entry name" value="PRK00811.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558:SF11">
        <property type="entry name" value="SPERMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="SPERMIDINE/SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000502">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="12"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ47231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="297" mass="33900" checksum="3818BA932586F688" modified="2010-10-05" version="1">MAQELTHPAIKDGWFAEISDTMWPGQAMSLKVEKVLHVEKSKYQDVLVFKSTTYGNVLVLDNCIQVTERDEFSYQEMITHLALNSHPNPKKALVIGGGDGGVLREILKHESIEEAWLCDIDETVIEVSKKYLPNMAKSYDDPRTRVHIGDGFKFLEEYKNQFDVIITDSSDPEGPAESLFQKPYFQLLKDALTEKGVITTQAENMWIHMDIISKLKKDCNEIFPVAEYAYTMIPTYPSGSIGFMVCSKDPNANVSKPIRFDWSDEFVAKNLKYYNKKIHEAAFVLPTWADQVLNKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK80</accession>
    <name>C4YK80_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pho86p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK80"/>
    <dbReference type="PaxDb" id="5476-C4YK80"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05877"/>
    <dbReference type="HOGENOM" id="CLU_076919_0_0_1"/>
    <dbReference type="OMA" id="ELWGVQF"/>
    <dbReference type="OrthoDB" id="4082764at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024297">
        <property type="entry name" value="Pho86"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11124">
        <property type="entry name" value="Pho86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="38537" checksum="CECB9FFC239475F0" modified="2009-07-28" version="1">MVVQKEIDLNKPLDANAAPVLAKTTLKPELSKAAIVLHGDRYKQLQAKLTKYVLWHPISIVVYTTVLPVVVGYALWDYISISDNLIEFYHIMMKEKKDFIFSFFTAFPLFASVFASFGFLAYIVGEDMGIITSKFYAQKYCDYIFGFDIKSYSQNETGKDKKLTRKSLDTQLIVYRDSPIAICSLVVDETQSSAANFIVKITGIHVRKVFQKVNFDEVLIDWAVVRARELYQEFLTSKNIKTPPENSSILITIDAYSFDNAFEKTLYNHGFRILDSSFELNPFSPAVSWYKERLYRFLNVSRDTFGLMLTIAKDDIESINSDTKQNNQSKIKKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK87</accession>
    <name>C4YK87_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-specific glutamate dehydrogenase</fullName>
            <ecNumber evidence="4">1.4.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_05884</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-glutamate + NAD(+) + H2O = 2-oxoglutarate + NH4(+) + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.2" evidence="4"/>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK87"/>
    <dbReference type="PaxDb" id="5476-C4YK87"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05884"/>
    <dbReference type="HOGENOM" id="CLU_005220_0_0_1"/>
    <dbReference type="OMA" id="DEYGMTS"/>
    <dbReference type="OrthoDB" id="184415at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056365">
        <property type="entry name" value="NAD-GDH_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016210">
        <property type="entry name" value="NAD-GDH_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055480">
        <property type="entry name" value="NAD-GDH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF24">
        <property type="entry name" value="NAD-SPECIFIC GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23147">
        <property type="entry name" value="GDH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23152">
        <property type="entry name" value="GDH_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000184">
        <property type="entry name" value="GDH_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="5">
        <location>
            <begin position="674"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ47316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1056" mass="119788" checksum="8145DC2E41936133" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK97</accession>
    <name>C4YK97_CANAW</name>
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        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">CAWG_05894</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
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    </organism>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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                <person name="Kellis M."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">WO-1</strain>
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        </subcellularLocation>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
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    </dbReference>
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        <property type="entry name" value="Peflin/Sorcin_CaBP"/>
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        <property type="entry name" value="GH27120P"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        </location>
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        </location>
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    </feature>
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        </location>
    </feature>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="371" mass="42394" checksum="C2C9DB58A800F620" modified="2009-07-28" version="1">MDDLPPQPTPQQSYSQSQHHGSQPSHHSHHNNSNRKYPQQAQQQYKVSYRPPPPQQQQQPQQPSPHYQQVPPQQQVPPQQQYQQYNTPPQQEYYQQAPGHSRVPPQGGYQQPYSNVPPQQQYSSAPPPPSMQYQQRPSYSSPPPAQQQVYQQHAPSQSSQAAQYQPQTSNNGHYSKHNISRDSLETTKTTATTSSKQKLESELRSVFEKVDTNGSGRISAKELSHALLNFDRSRFQDSTIKLMINLFCGPDSATKSLNFEQFVSLWKYLSAYKKLFIQADTNKSGDISFGEFQKILEQIGYKLDIDLVLNLFQKYALLESGGVGKLRFDNFIELLVYLRKLTDVFKKYDKDLSGTATIGFSDFLFEVTNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKL3</accession>
    <name>C4YKL3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CAWG_06019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKL3"/>
    <dbReference type="PaxDb" id="5476-C4YKL3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06019"/>
    <dbReference type="HOGENOM" id="CLU_442103_0_0_1"/>
    <dbReference type="OMA" id="FSTPHAN"/>
    <dbReference type="OrthoDB" id="4026708at2759"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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        <location>
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            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="711" mass="78783" checksum="FAAD8CAF3D61C640" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKP9</accession>
    <name>C4YKP9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_06055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKP9"/>
    <dbReference type="PaxDb" id="5476-C4YKP9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06055"/>
    <dbReference type="HOGENOM" id="CLU_426405_0_0_1"/>
    <dbReference type="OMA" id="CRPHKQK"/>
    <dbReference type="OrthoDB" id="4025261at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="605" mass="66771" checksum="E0F5E92D34B09F97" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL17</accession>
    <name>C4YL17_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="6">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_01531</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="6"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL17"/>
    <dbReference type="PaxDb" id="5476-C4YL17"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01531"/>
    <dbReference type="HOGENOM" id="CLU_023643_7_2_1"/>
    <dbReference type="OMA" id="ATHSCID"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017328">
        <property type="entry name" value="Sirtuin_class_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037938">
        <property type="entry name" value="SIR2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="12">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 10">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="27"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="37"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="202"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="226"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ43298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="331" mass="37581" checksum="2748DFB84ED06286" modified="2009-07-28" version="1">MPSLDDILKPVAEAVKNGKKVTFFNGAGISTGAGIPDFRSPDTGLYANLAKLNLPFAEAVFDIDFFKEDPKPFYTLAEELYPGNFAPTKFHHFIKLLQDQGSLKRVYTQNIDTLERLAGVEDKYIVEAHGSFASNHCVDCHKEMTTETLKTYMKDKKIPSCQHCEGYVKPDIVFFGEGLPVKFFDLWEDDCEDVEVAIVAGTSLTVFPFASLPDEVNKKCLRVLVNKEKVGTFKHEPRKSDIIALHDCDIVAEKLCTLLGLDDKLNEVYEKEKIKYSKAETKETKMHEIEDKLKEEAHLKEDKHTTKVDKKEKQNDANDKELEQLIDKLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL34</accession>
    <name>C4YL34_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_01548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL34"/>
    <dbReference type="PaxDb" id="5476-C4YL34"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01548"/>
    <dbReference type="HOGENOM" id="CLU_150775_0_0_1"/>
    <dbReference type="OMA" id="MQFYTIY"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="143" mass="17550" checksum="C8E12CCAA00C5B78" modified="2009-07-28" version="1">MQFYTIYRNTTKAKKKKIKEVYTANDKYCNQSQNRLNLNILLRDHEYPAYFSIDYTFSRMCSYLQTMLVQNWLRSYQLNFLLYKHHVSLRIFILIFHFEATNTFFHHQYIFHLLMDCLSNILKHDTLTCQKGYKKEPHSPFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL77</accession>
    <name>C4YL77_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase DBP2</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP-dependent RNA helicase dbp2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_01593</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL77"/>
    <dbReference type="PaxDb" id="5476-C4YL77"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01593"/>
    <dbReference type="HOGENOM" id="CLU_003041_16_9_1"/>
    <dbReference type="OMA" id="STMPKFE"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17966">
        <property type="entry name" value="DEADc_DDX5_DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="159"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="359"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="515"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ43358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="562" mass="61311" checksum="50B6AA07CFBC7814" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL83</accession>
    <name>C4YL83_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_01600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL83"/>
    <dbReference type="PaxDb" id="5476-C4YL83"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01600"/>
    <dbReference type="HOGENOM" id="CLU_099495_0_0_1"/>
    <dbReference type="OMA" id="IRHNFQK"/>
    <dbReference type="OrthoDB" id="4076672at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="217" mass="25475" checksum="3568D13FE4CB33BE" modified="2009-07-28" version="1">MTNKGKLSKTISKYFANTIGFSCRITPPPNTSLELDYLLHNFHKLAPLDNFQTISNSNHGFFINAIYSPCRDESWFKLIKPDENHLFEEIDPKFTNTIKNDFINKLTSLVAIPRYSYIENNKDFQNYKLQIRFDHNIQRSIANYKGKYNLTTSTVDDPFISIINNDNANGTNNDDDDEVSIDYEKLRVNLRHNFQKFHKFDKIEIITNPNRLINRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLH1</accession>
    <name>C4YLH1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lipid droplet-associated hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_01689</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. LDAH family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLH1"/>
    <dbReference type="ESTHER" id="canal-q5a042">
        <property type="family name" value="LIDHydrolase"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YLH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01689"/>
    <dbReference type="HOGENOM" id="CLU_018394_1_1_1"/>
    <dbReference type="OMA" id="WVPVSYY"/>
    <dbReference type="OrthoDB" id="448051at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019363">
        <property type="entry name" value="LDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390:SF0">
        <property type="entry name" value="LIPID DROPLET-ASSOCIATED HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10230">
        <property type="entry name" value="LIDHydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ43452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="37162" checksum="67D02F79E383F148" modified="2009-07-28" version="1">MTVTYLNTTPKTPVYHKPPLEKSTATNIFVLIPGNPGLVDFYISYLDSIRKHFPQFETLCIGHVGFLDSTKRKIYDVPSQIEHKYDVLKQLILTKNESNLIPNLYFLHHSMGSFVYQRTIRKLYHDENLNGKFNIKFSGFVTPTIHNISASSSGRVLSGLMQRNVPIVSIVLVFRFFVSLIPALILRKLLHYHLLGNKTGDGFENSVEGAYKIVKSGTVVNQALEMAKEEMLIIDTQDDINDWYFNHSNKGIKNWLFFARNDHWVANETREYLIDKYDNSDNTICEVCDDETNPISHSFCVAQSDQFAKITVARIKEICNIDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLM8</accession>
    <name>C4YLM8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_01747</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLM8"/>
    <dbReference type="SMR" id="C4YLM8"/>
    <dbReference type="PaxDb" id="5476-C4YLM8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01747"/>
    <dbReference type="HOGENOM" id="CLU_080796_0_0_1"/>
    <dbReference type="OMA" id="YIRDAWK"/>
    <dbReference type="OrthoDB" id="10255148at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ43509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="204" mass="24329" checksum="D161964D98F6A8C4" modified="2010-10-05" version="1">MGAYKYLEELQRKKQSDVMRFLYRVRCWEYRQKNVIHRASRPSRPDKARRLGYKAKQGFVIYRIRVRRGGRKRPVPKGATYGKPTNQGVNQLKYQKSLRSTAEERVGRRASNLRVLNSYWVNQDSTYKYFEVILVDPSHKAIRRDARYNWIVNPVHKHREARGLTSAGKKSRGINKGHLFNKTKAGRRHTWKKHNTLSLWRYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLR3</accession>
    <name>C4YLR3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylinositol N-acetylglucosaminyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_01782</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLR3"/>
    <dbReference type="PaxDb" id="5476-C4YLR3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01782"/>
    <dbReference type="HOGENOM" id="CLU_024002_2_1_1"/>
    <dbReference type="OMA" id="STSYHAF"/>
    <dbReference type="OrthoDB" id="196709at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016104">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ43544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="34957" checksum="EC64EA9E056A7C5C" modified="2009-07-28" version="1">MEEIHISSSILQDSDSAPPNHFQHAQQQEQPSWKKLLYLQQPFPDNYTDQSFLSQLKRNTTVAKYSYKNLVQAFSFIVFYISCILLVILMFIGIYEKQWDPIIPTLISTGISLVGFFSLKNLSMNMRSFMVITFILLIVSPILKSLTKSTSSDSIWAISCVLCLANSIFHDYSMKVSYRPIVSTNISLSNAIVLASRLSTTLDVFLFVLFAIEVNILLPLFDAKIRLSGLETIHWPIAFLTFNLTSYLMYILLNYKFLVYWILSVFVMVVIMPIYFLSLQRYKNEIQGPWDVAKPKLMKSSIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLS3</accession>
    <name>C4YLS3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cell division control protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_01792</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLS3"/>
    <dbReference type="SMR" id="C4YLS3"/>
    <dbReference type="PaxDb" id="5476-C4YLS3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01792"/>
    <dbReference type="HOGENOM" id="CLU_017718_7_1_1"/>
    <dbReference type="OMA" id="QCEFVYL"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000144">
        <property type="term" value="C:cellular bud neck septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043934">
        <property type="term" value="P:sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000260">
        <property type="entry name" value="Cell division control 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="9">
        <location>
            <begin position="34"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="310"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ43554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="357" mass="40684" checksum="7C25CC98376749E2" modified="2009-07-28" version="1">MSIEEPSTQHIAQPQKYVGFDTITTQIENRLLKRGFQFNIMVVGRSGLGKSTLVNTLFSSKLTTSQGRKSPSEPIEKTTEIKVASHSLLENNVRLNINVIDTPGFGDQINNEKCWEPLVKYVKEQHSQYLRKELTAQRDKFLADTRVHCILYFIPPNGQKLKQLDVQALKKLSEIANVVPIIAKSDSLTLDERSEFKKLLQSEFMKYNFNIYPYDSEDLYEEERQLNEDIKSLIPFAIAGSETEIEINGEMVRGRKTKWGAINIEDVSQCEFVFLRDFLTRTHLQDLIETTALTHYETFRSKQLIALKENASNPNRQSQLQKDQGQTSQQSNQDLKNTSGVPNAPMFQSTTGTAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLS8</accession>
    <name>C4YLS8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_01797</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">MFS antiporter that does not display functional linkage as drug transporter and performs functions that significantly affect biofilm development and virulence. No substrate for transport has been identified yet, but plays an important role in the growth in the host.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. CAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLS8"/>
    <dbReference type="PaxDb" id="5476-C4YLS8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01797"/>
    <dbReference type="HOGENOM" id="CLU_008455_8_7_1"/>
    <dbReference type="OMA" id="FQAFGSC"/>
    <dbReference type="OrthoDB" id="3066029at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005275">
        <property type="term" value="F:amine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001765">
        <property type="term" value="P:membrane raft assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000172">
        <property type="entry name" value="MFS multidrug resistance transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF21">
        <property type="entry name" value="DITYROSINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="70"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ43559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="505" mass="55525" checksum="FD23DD698E42FC21" modified="2009-07-28" version="1">MNSVTNPEIMPKKEEPKQNKTEAETENKLSTADLKNGKSVSDSEKQNDLEGQTSQDSPYCALSLKRKTIIIGIVTIAGCLGPISGNIYIPILPQLENEFHVSTQVINGTVSAFMFVFAIAPLIWASWADYGGRKTLYLIPLIFFILANILLAATPANIVGLYILRVLQAFGASSVISVGAGTVADIIEPKHRAKAISVFMWGPQLGPVLGPVLSIIAAKGQWRWIFGFLALFGFAVYLMILFFLPETLRYLVGNCSCYKDNSIIVKPHLRQKKIVEGYPVPPKPSFKNYWILIKFKPVLLCSINSGLLFATFYGLMVTFAHVLKIEYSFTDAQISASYLCPGISLIIGSTIGGWASDKIRAEIIKHNPDIYVPEYRFSLQFLGLIISMTGVIGYGWTVHKHTNVVAVFIFTFLGGFGMTWVFVANTTYLTECTTGQPATNVAIGNFARNISATICTAVIDPLISSMGFGWCLTGLGLTNILGIVFVVILLKWGPSWRRQFLNKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLY6</accession>
    <name>C4YLY6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase MNT3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_01858</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLY6"/>
    <dbReference type="PaxDb" id="5476-C4YLY6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01858"/>
    <dbReference type="HOGENOM" id="CLU_024327_4_2_1"/>
    <dbReference type="OMA" id="WSYPSHI"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946868" description="Mannosyltransferase MNT3" evidence="7">
        <location>
            <begin position="24"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="45353" checksum="AEE486F26E290597" modified="2009-07-28" version="1">MLRHLVFILIAILLLTFPPKIESLFKSFIINKPTKTTCYQYTTREQLKSILESDIHETNFCIEKPSTSPPKTNSTLLMLCQNSDIFSVLETIQNIQDRFNDKYNYDYTFLNDVPFNYEFIYLVSSIIPHGKINFGLIPIEHWSYPSHINILLATEIRQNYANVPYGDSESYRHMCRFYSGFFYKHELVKQYQYYWRIEPGIKIYCDIDYDVFEYMIINDKKYGFVISLFEYLETIPTLWNHVVQYINDNEIKSELLPLLTNKYNWYNLCHFWSNFEIANLDIFNNDDYENFFQYLDNLGGFYYERWGDAPIHSIAIALFLQKKDIHWFENIGYYHVPYLQCPQDIDLYVKNKCTCNPDEDFTWSDLSCTNHFLNILHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM53</accession>
    <name>C4YM53_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM53"/>
    <dbReference type="PaxDb" id="5476-C4YM53"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01929"/>
    <dbReference type="HOGENOM" id="CLU_021104_0_0_1"/>
    <dbReference type="OMA" id="YFIPEVA"/>
    <dbReference type="OrthoDB" id="3980854at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="584" mass="66156" checksum="34AF14685F886F4A" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM95</accession>
    <name>C4YM95_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_01973</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM95"/>
    <dbReference type="PaxDb" id="5476-C4YM95"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01973"/>
    <dbReference type="HOGENOM" id="CLU_007738_2_0_1"/>
    <dbReference type="OMA" id="QNMSGDP"/>
    <dbReference type="OrthoDB" id="2192946at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF33">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="7">
        <location>
            <begin position="92"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="446"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="871" mass="101556" checksum="BBC5124D78B7494A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YME5</accession>
    <name>C4YME5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Meiotic nuclear division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_02024</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MND1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YME5"/>
    <dbReference type="PaxDb" id="5476-C4YME5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02024"/>
    <dbReference type="HOGENOM" id="CLU_080628_2_0_1"/>
    <dbReference type="OMA" id="VCYWAFP"/>
    <dbReference type="OrthoDB" id="9978204at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005647">
        <property type="entry name" value="Mnd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040453">
        <property type="entry name" value="Mnd1_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03962">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026991">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mnd1 HTH" evidence="7">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="79"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR026991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="201" mass="23362" checksum="4EC94A6DE5E9EDD0" modified="2009-07-28" version="1">MPPKKGLTQEEKLSALLNWFQSDHMFYTLKEIESKASKQCKIPPMQMKELVLALVEEGLVEQDRCGTTNLYWSFPYLQHKKQQETHDRLNRTIANLEMERDSLLCRCKDETGVRNQTHERASKIRFCDQSSERIDSIQSQLQSLKESESVENLVTSLAFFSDSIDDIICYLSRQTGLTMTTLKTEFELPLEFEEIRPGTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMF7</accession>
    <name>C4YMF7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial 54S ribosomal protein YmL8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_02037</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMF7"/>
    <dbReference type="SMR" id="C4YMF7"/>
    <dbReference type="PaxDb" id="5476-C4YMF7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02037"/>
    <dbReference type="HOGENOM" id="CLU_074407_1_0_1"/>
    <dbReference type="OMA" id="HIQTTYA"/>
    <dbReference type="OrthoDB" id="275000at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="entry name" value="Ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_bL17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_bL17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="Prokaryotic ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="200"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ43788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="29389" checksum="62463439711AFAAD" modified="2010-10-05" version="1">MPKVFTIQKNVASHKKMIYKNLCANLIRHEYIVTTSAKAKAAQPYIEKFLANTIKQNKELPEAVTNLEDKLKSIKALSYLQPPDRVECGSKMLEDIINRYPQRTHGFTRVIKLEPRLGDDKAPMSVIELVDSNYEIKLWYTAKTVARLELQGIELDDITELNIKKLTQYRVNGEQVFREAVETCKKEFFNVAEETGEVPEEIKSDLSNLPNMSRHSGELKGKLLVSKQFKTKPRPERQSINIPQSPFLKQQQEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMI4</accession>
    <name>C4YMI4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMI4"/>
    <dbReference type="PaxDb" id="5476-C4YMI4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02066"/>
    <dbReference type="HOGENOM" id="CLU_007526_0_2_1"/>
    <dbReference type="OMA" id="RAFYVME"/>
    <dbReference type="OrthoDB" id="191037at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="45"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="403" mass="45526" checksum="B8E4566BA33EB53A" modified="2009-07-28" version="1">MSAPELTDIRSPLDINKLKDLLASATTSQSSKVVLGHKATVPTTFSEIKQFTFGQSNPTYFLSTPEGKNYVLRRKPSPNSKLISKSAHAVEREFFILNAINILNSESDNLTVPVPKVHLLCEDESQIGYVFYIMDYVNGIQIKNPSMPGIEESDQNQYWKSIIETIAAIHLLNVEKLISLLPKSHFPQFQNIEKLKSTSYFARQIKTLNNIHNLQSQHVPPIPDFDKITGWLQKYAPQDPDKLTLIHGDLKIDNILFDPKSKTVCGVLDWELTTVGNPLFDLANFLQAFQLPNKLNRMLYYPQKTEMGAENKNSTAFLYEKLHEYEKLVTWSKTDSKNNPSELWPIGHTFGLLRLSVISQGIAMRVKLGNASSANAKGYASMYPYLSELAMENVNKTKKTSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMJ2</accession>
    <name>C4YMJ2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitric oxide dioxygenase</fullName>
            <ecNumber evidence="4">1.14.12.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_02074</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 nitric oxide + NADH + 2 O2 = 2 nitrate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 nitric oxide + NADPH + 2 O2 = 2 nitrate + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="4"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMJ2"/>
    <dbReference type="PaxDb" id="5476-C4YMJ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02074"/>
    <dbReference type="HOGENOM" id="CLU_003827_12_0_1"/>
    <dbReference type="OMA" id="ADIHYEV"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase NAD(P)H activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071500">
        <property type="term" value="P:cellular response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046210">
        <property type="term" value="P:nitric oxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19754">
        <property type="entry name" value="FHb_fungal-globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06184">
        <property type="entry name" value="flavohem_like_fad_nad_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.10:FF:000003">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000034">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000076">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00409">
        <property type="entry name" value="PHDIOXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0216">Detoxification</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin" evidence="16">
        <location>
            <begin position="9"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="17">
        <location>
            <begin position="156"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049433"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ43823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="398" mass="45805" checksum="400D14C8E801CB69" modified="2010-10-05" version="1">MTVEYETKQLTPAQVKIILDTVPILEEAGETLTQKFYQRMIGNYDEVKPFFNTTDQKLLRQPKILAFALLNYAKNIEDLTPLTDFVKQIVVKHIGLQVLPEHYPIVGTCLIQTMVELLPPEIANKDFLEAWTIAYGNLAKLLIDLEAAEYAKQPWRWFKDFKVTRIVQECKDVKSVYFTPVDKDLLPLPKPERGQYLCFRWKLPGEEFEISREYSVSEFPKENEYRISVRHVPGGKISGYIHNNLKVGDILKVAPPAGNFVYDPATDKELIFVAGGIGITPLLSMIERALEEGKNVKLLYSNRSAETRAFGNLFKEYKSKFGDKFQAIEYFSEDNNTDDKIVIDKAFNRKLTTDDLDFIAPEHDVYLVGPREFMKDIKEHLGKKNVPVKLEYFGPYDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMJ7</accession>
    <name>C4YMJ7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EEQ43828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="136" mass="16346" checksum="2AE5A7C6EC3B4088" modified="2009-07-28" version="1">MTKEKERHFSFFLSGKTGGAKRRISRKRVTDFYSYIELSVVVLYFFQVFSSSAFVITSFIISQYTHYTLHPQIYIYTLFLLLFNTFFLYLVFIFNFLPFLYSFSHSFFGFPFFPSSSLLLHFVFSFVSTFFFFVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMP5</accession>
    <name>C4YMP5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_02129</name>
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    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="PaxDb" id="5476-C4YMP5"/>
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    <dbReference type="HOGENOM" id="CLU_017633_10_5_1"/>
    <dbReference type="OMA" id="HTCEVNL"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000245">
        <property type="entry name" value="DnaJ domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="176"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="176"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="477"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="498"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ43876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="539" mass="60228" checksum="2B23824A3CE21531" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMX4</accession>
    <name>C4YMX4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">beta-glucosidase</fullName>
            <ecNumber evidence="5 14">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_02211</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5 14"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMX4"/>
    <dbReference type="PaxDb" id="5476-C4YMX4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02211"/>
    <dbReference type="HOGENOM" id="CLU_004542_2_0_1"/>
    <dbReference type="OMA" id="VVMESWI"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000757">
        <property type="entry name" value="Beta-glucosidase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF2">
        <property type="entry name" value="BETA-GLUCOSIDASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibronectin type III-like" evidence="15">
        <location>
            <begin position="732"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEQ43955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="815" mass="90603" checksum="B523B76A5926C982" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNE0</accession>
    <name>C4YNE0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_01399</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNE0"/>
    <dbReference type="SMR" id="C4YNE0"/>
    <dbReference type="PaxDb" id="5476-C4YNE0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01399"/>
    <dbReference type="HOGENOM" id="CLU_012153_0_0_1"/>
    <dbReference type="OMA" id="CCAGRTA"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000507">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="4">
        <location>
            <begin position="11"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ43173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="432" mass="49077" checksum="F6A58D4B55CC47D5" modified="2009-07-28" version="1">MTVTIPLTETNLFKPISIGDVKLNHRIVHAPTSRKRSTKDNYPTDLMIDYYKSRSQYPRSFIIFESCLVSERSGLVPHKIGLWDEKHCLALKQIVDQVHNNNCVISCQIMANGRTSNAKLMQSKNLPILAPSITYPNEAAEKLATELNFPIKPLTVDEIHNIQDDFVNAAVNSLKIADFDFVELHATSGFLIEQFLSPLSNKRTDEYGGDLVNRCRFLIEIIDKFINHPDIGPKKFGVRISPWYSHNGMVYPEEVNLEDGIPYQFCQYILKQLEVRKSQGNEIAYVSIVEPRVSGNSDVDSFGDKSNDEIIKSWSGKLIRAGGYATNFNVENPTLIKTNKQVTNEGGEIVHYANLINDVNNDDRTLIGFSRPFTSNPDLVYRLENNLKLEYYDRPTFYTQTGEGYLTFKNYDGSAVTKLPEKELMREGISLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNH3</accession>
    <name>C4YNH3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Hyphally-regulated cell wall protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_01434</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HYR1/IFF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNH3"/>
    <dbReference type="PaxDb" id="5476-C4YNH3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01434"/>
    <dbReference type="HOGENOM" id="CLU_268223_0_0_1"/>
    <dbReference type="OMA" id="HIHESAY"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031573">
        <property type="entry name" value="Cell_wall_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021031">
        <property type="entry name" value="Hyphal-reg_cell_wall_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11765">
        <property type="entry name" value="Hyphal_reg_CWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15789">
        <property type="entry name" value="Hyr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 14" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946775" description="Hyphally-regulated cell wall protein N-terminal domain-containing protein" evidence="14">
        <location>
            <begin position="21"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1204"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="domain" description="Hyphally-regulated cell wall protein N-terminal" evidence="15">
        <location>
            <begin position="12"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF11765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEQ43207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1225" mass="133573" checksum="9FF927B35B6C4E27" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNK2</accession>
    <name>C4YNK2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Signal recognition particle 54 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_01464</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SRP54 binds to the signal sequence of presecretory protein when they emerge from the ribosomes. SRP54 interacts with the scR1 RNA and mediates the association of the resulting SRP-RNC complex with the signal recognition particle receptor (SR) via its alpha subunit SRP101. Both, SRP54 and SRP101, are locked in their GTP bound forms in the SRP-RNC-SR complex, which dissociates upon transferring the signal sequence to the protein-conducting channel (translocon). After signal sequence transfer, SRP54 and SRP101 act as reciprocal GTPase-activating proteins (GAPs), thereby resolving their association.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Fungal signal recognition particle consists of a 7S RNA molecule (scR1) and at least six protein subunits: srp72, srp68, srp54, sec65, srp21 and srp14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The M domain binds the 7SL RNA and the signal sequence of presecretory proteins.</text>
    </comment>
    <comment type="domain">
        <text evidence="13">The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit srp101. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNK2"/>
    <dbReference type="PaxDb" id="5476-C4YNK2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01464"/>
    <dbReference type="HOGENOM" id="CLU_009301_6_1_1"/>
    <dbReference type="OMA" id="GMTGQDA"/>
    <dbReference type="OrthoDB" id="10250817at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.30:FF:000003">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="15">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
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            <dbReference type="EMBL" id="EEQ44606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="751" mass="82683" checksum="4268D46E1DC8854D" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNX2</accession>
    <name>C4YNX2_CANAW</name>
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        <recommendedName>
            <fullName evidence="5">Anaphase spindle elongation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02905"/>
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    <dbReference type="OMA" id="KRITRHF"/>
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    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="686"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="830"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="559"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
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        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
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        <location>
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            <end position="703"/>
        </location>
    </feature>
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        <location>
            <begin position="704"/>
            <end position="714"/>
        </location>
    </feature>
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        <location>
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            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="830"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="906" mass="104835" checksum="DB010290F9B778B1" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNX8</accession>
    <name>C4YNX8_CANAW</name>
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        <submittedName>
            <fullName evidence="10">Mannan polymerase complexes MNN9 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="10 11">
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        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNX8"/>
    <dbReference type="SMR" id="C4YNX8"/>
    <dbReference type="CAZy" id="GT62">
        <property type="family name" value="Glycosyltransferase Family 62"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YNX8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02911"/>
    <dbReference type="HOGENOM" id="CLU_017872_4_0_1"/>
    <dbReference type="OMA" id="IPKTREG"/>
    <dbReference type="OrthoDB" id="2405412at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF6">
        <property type="entry name" value="MANNAN POLYMERASE COMPLEXES SUBUNIT MNN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ44637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="368" mass="42782" checksum="930DCC64EE8F5EF5" modified="2009-07-28" version="1">MVHYRNRYLNYIRRKPLALLAPITLLVVIYFYFFSAHGFSSNKQKYNYNKKSRGWFYKNRDTVILKDLPKNHISHYDLNKLTASKDALNKREEVLILTPMSKFLPEYWENINKLTYDHSLISLGFIFPRTTQGDDALKELENALKKTKREKRLNFKKITILRQDSNSLQSQLEKDRHAFKVQKERRSMMALARNSLVFSTILPSTSWVLWLDADIVETPVTLIQDLTGHNKPVVSANVHQRFINQDTKQPDIRPYDFNNWVESEEGLKLAASLPDDEIIVEGYSEMVTHRALMAHFYDPKGDPSTEMTLDGVGGGAVMVKADVHRDGAMFPSFPFYHLIETEGFAKMAKRLGYEVYGLPNYLVFHYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNY8</accession>
    <name>C4YNY8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Guanosine-diphosphatase</fullName>
            <ecNumber evidence="11">3.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAWG_02921</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GDP + H2O = GMP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22156"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.1.42"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNY8"/>
    <dbReference type="SMR" id="C4YNY8"/>
    <dbReference type="PaxDb" id="5476-C4YNY8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02921"/>
    <dbReference type="HOGENOM" id="CLU_010246_4_1_1"/>
    <dbReference type="OMA" id="WTCRIKE"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24040">
        <property type="entry name" value="ASKHA_NBD_GDA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000052">
        <property type="entry name" value="Ectonucleoside triphosphate diphosphohydrolase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.150:FF:000009">
        <property type="entry name" value="Guanosine-diphosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="41"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="117"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="317"/>
            <end position="321"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEQ44647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="599" mass="65953" checksum="D5BC3A4F6E1B646A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP31</accession>
    <name>C4YP31_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphatidyl-N-methylethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="17">2.1.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Phospholipid methyltransferase</fullName>
            <shortName evidence="17">PLMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAWG_02967</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32739"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 17">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Endoplasmic reticulum membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Mitochondrion membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.71" evidence="17"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YP31"/>
    <dbReference type="PaxDb" id="5476-C4YP31"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02967"/>
    <dbReference type="HOGENOM" id="CLU_086119_0_0_1"/>
    <dbReference type="OMA" id="PTFWNIA"/>
    <dbReference type="OrthoDB" id="8300106at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000773">
        <property type="term" value="F:phosphatidyl-N-methylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000005">
        <property type="entry name" value="Phosphatidylethanolamine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03216">
        <property type="entry name" value="PLMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024960">
        <property type="entry name" value="PEMT/MFAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458:SF5">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005444">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51599">
        <property type="entry name" value="SAM_PEMT_PEM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 17" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13 17" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14 17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Lumenal" evidence="17">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="17">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="17">
        <location>
            <begin position="144"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="17">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="209"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEQ44690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="225" mass="25425" checksum="0D179A56400976B7" modified="2010-10-05" version="1">MSSIAQELSTLPSDLIYLAQNFPQYIDLKGKLFGNDIIQNQLIYSIICISFNPIFWNIVARLEYKTHFLTKICFNSAKLGCYVLAITIFSLGIYRDHVYYQALETQPTYQPLIDSIIIKSLAIALFAFGNVLVISSMYALGVTGTYLGDYFGILMDHRVTGFPFNINDNPMYNGSSLCFLATALWYGKPAGIAVAIYVFVMYKIALLFEEPFTAKIYANRIDKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ84</accession>
    <name>C4YQ84_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminopeptidase P N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_02640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ84"/>
    <dbReference type="PaxDb" id="5476-C4YQ84"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02640"/>
    <dbReference type="HOGENOM" id="CLU_017266_1_1_1"/>
    <dbReference type="OMA" id="DSYFWYL"/>
    <dbReference type="OrthoDB" id="4215474at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="7">
        <location>
            <begin position="47"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ44373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="490" mass="55137" checksum="3EACFF434AAEF47B" modified="2009-07-28" version="1">MKSRIALTLRRFISTRPRLFTTYTTGQPTYETRPHIITQPGVLTPGISAMEYYQRRLKLSTHLPSKSLAIIIGNTTQFSSGSVFYDFQQDNDLYYLTGWLEPDSVVAIEKKGENGEDDVVLHMLVPPKDPKKELWEGPKSGLEGAYNIFNADLVEDISQAPSYLKQLIKQNDYIYWDKKFNSKQNEGLRQFFNFSTNHRHHQDINEIIENSKKSVQKLSPVVAKLRAIKSDAEVSVMKRACEISSVAINRAMATVGSDDPINSENMLARYLEYQFVKGGCEKNAYIPVVASGSNALCLHYTRNDDLIKKNELIFIDAGGKLGGYCADISRAWPNSTDGFTDTQRDIYEVVLATNKKCITLCSESLGYSFHDIHEVSVNTLKHELKNLPGFGDVTFSDISRIYYPHYVGHNVGLDLHDIPSVSNRLPLKQNQVITIEPGLYIPHDGPKHYRGIGLRIEDNVVVGKTHRDIINLTSGCKKEVSDIEALVRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQB6</accession>
    <name>C4YQB6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutaredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQB6"/>
    <dbReference type="SMR" id="C4YQB6"/>
    <dbReference type="PaxDb" id="5476-C4YQB6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02673"/>
    <dbReference type="HOGENOM" id="CLU_125054_0_0_1"/>
    <dbReference type="OMA" id="DIYCYDV"/>
    <dbReference type="OrthoDB" id="429967at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008554">
        <property type="entry name" value="Glutaredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052565">
        <property type="entry name" value="Glutaredoxin-like_YDR286C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558:SF1">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05768">
        <property type="entry name" value="Glrx-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="78" mass="9275" checksum="47E09F2DCADDB7BF" modified="2009-07-28" version="1">MLCSNAKFILYDALKSPKLKNMPIKLTTIDIMDPKNQEAFDKYCYDVPVLHVDRPNQAKPVKFMHYFYEDKLLEEFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQH1</accession>
    <name>C4YQH1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nascent polypeptide-associated complex subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alpha-NAC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_02729</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD2 may also be involved in transcription regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAC-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQH1"/>
    <dbReference type="SMR" id="C4YQH1"/>
    <dbReference type="PaxDb" id="5476-C4YQH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02729"/>
    <dbReference type="HOGENOM" id="CLU_057806_2_1_1"/>
    <dbReference type="OMA" id="SQKMIFA"/>
    <dbReference type="OrthoDB" id="3169036at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22054">
        <property type="entry name" value="NAC_NACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14358">
        <property type="entry name" value="UBA_NAC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000002">
        <property type="entry name" value="Nascent polypeptide-associated complex (NAC), alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000006">
        <property type="entry name" value="Putative nascent polypeptide-associated complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016641">
        <property type="entry name" value="EGD2/NACA0like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21713">
        <property type="entry name" value="NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015901">
        <property type="entry name" value="NAC_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="8">
        <location>
            <begin position="16"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="82"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ44460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="178" mass="19510" checksum="419313E4F3226AE5" modified="2009-07-28" version="1">MSIEEIPQGADVNVIPKNEKKARELIKKLNLKQIKGISRVTFKQRGNLIYAIDSPDVYRSAAGTYVVFGEAKVDDMNQRIAEAQAQQAQQEALQKAAADAGKTEDKSPEAITADLEKASLGDKKAEDEEEDEGEIDETGLDPKDIEIVVEQTQVSRAKAVKALRNHDGDMVNAIMDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQM4</accession>
    <name>C4YQM4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FG-nucleoporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_02783</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQM4"/>
    <dbReference type="PaxDb" id="5476-C4YQM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02783"/>
    <dbReference type="HOGENOM" id="CLU_638015_0_0_1"/>
    <dbReference type="OMA" id="PFGQSQT"/>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051767">
        <property type="entry name" value="Nucleoporin_NUP42"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46527:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46527">
        <property type="entry name" value="NUCLEOPORIN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ44513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="36230" checksum="6C406022B82C1194" modified="2009-07-28" version="1">MFGANSSAFGTSGFGNKSSSGNAFANQSNPFATSSTNSGFGGFGAFKNTGASSNASSQQSGIGGFGAKSDAPSQSSAFGSTGLGNTTNTTTGFGSSGFGSTGFAKSTPPSNSGFGSSGFGAKSNPTASAFGQSGFGSSGFSQTNTSNSSSSPFGQMGNTNKPSPFGTTASQPSAFGSTATQPSNNKPSPFGQTNTSNSPFGSNTAATTAPTNTSSPFGSSNNNTSNPFGGQSSTSSPFGQTQTSSSTFGASNQTQSAFGTASTQNTNSGFGSNNSASTIANTNQNSSTTNNANPFGSTSEATPTFSFISTQPKSQPQTQTTSSIDVDIQESTQNDSLPASILEAFNGSMFTLGKIPDVPPPPELCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQR2</accession>
    <name>C4YQR2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_04409</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQR2"/>
    <dbReference type="PaxDb" id="5476-C4YQR2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04409"/>
    <dbReference type="HOGENOM" id="CLU_1854985_0_0_1"/>
    <dbReference type="OMA" id="WTIKSNT"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006838">
        <property type="entry name" value="ADTRP_AIG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989">
        <property type="entry name" value="ANDROGEN-INDUCED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989:SF16">
        <property type="entry name" value="AT02829P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04750">
        <property type="entry name" value="Far-17a_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ46065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="138" mass="16122" checksum="17B745E73FC7C243" modified="2009-07-28" version="1">MVYWTLRLFMLHLLTPDPENFNIPLGLDLCIHLMPVVSLLIDYLVFMPRWTIKSNTVLLLITALSTGYWCLLKYLVDTENGGRYPYAFMDMEDDGLRALVFVAVGLVAFLQFHFMRNIYDVVVKKTETVDIEIDRKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR40</accession>
    <name>C4YR40_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Glutathione reductase</fullName>
            <ecNumber evidence="3 16">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAWG_04539</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 16">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 16">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="3 16"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR40"/>
    <dbReference type="PaxDb" id="5476-C4YR40"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04539"/>
    <dbReference type="HOGENOM" id="CLU_016755_2_2_1"/>
    <dbReference type="OMA" id="MSKHYDY"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="PHI-base" id="PHI:4904"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000003">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000235">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13 15" id="KW-0274">FAD</keyword>
    <keyword evidence="5 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="18">
        <location>
            <begin position="38"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="17">
        <location>
            <begin position="402"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="505"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="235"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="14">
        <location>
            <begin position="77"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEQ46193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="516" mass="56451" checksum="BFF511C5E12C534D" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR42</accession>
    <name>C4YR42_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR42"/>
    <dbReference type="PaxDb" id="5476-C4YR42"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04541"/>
    <dbReference type="HOGENOM" id="CLU_1834885_0_0_1"/>
    <dbReference type="OMA" id="CLEFREF"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="140" mass="16012" checksum="83D589087586E3B8" modified="2009-07-28" version="1">MFCFSCCCGVDWIRLFSFIFLGVCLEFREFLGSRSTSRNFQNIESDSFRNWSTLTNGDNITFFNSESWRDVGSNILVSFFVSVIFWNVMQVISSDNDGTVHFGGNNSTGQDFTSDGNSTSEWTFFVNVRTFNGSFWGFET</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR70</accession>
    <name>C4YR70_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_04569</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR70"/>
    <dbReference type="PaxDb" id="5476-C4YR70"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04569"/>
    <dbReference type="HOGENOM" id="CLU_013659_0_0_1"/>
    <dbReference type="OMA" id="VDDNKWM"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000076">
        <property type="entry name" value="Tac1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="867"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="867"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="880"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ46223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="980" mass="111454" checksum="8179AAAFC9B69187" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRJ7</accession>
    <name>C4YRJ7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_04697</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRJ7"/>
    <dbReference type="PaxDb" id="5476-C4YRJ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04697"/>
    <dbReference type="HOGENOM" id="CLU_283151_0_0_1"/>
    <dbReference type="OMA" id="FIKIYTL"/>
    <dbReference type="OrthoDB" id="205099at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="11">
        <location>
            <begin position="26"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1153"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1192"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1154"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1204"/>
            <end position="1219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
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    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS08"/>
    <dbReference type="PaxDb" id="5476-C4YS08"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04866"/>
    <dbReference type="HOGENOM" id="CLU_007367_1_0_1"/>
    <dbReference type="OMA" id="CFITADQ"/>
    <dbReference type="OrthoDB" id="5368485at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00741">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016445">
        <property type="entry name" value="Rog1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF62">
        <property type="entry name" value="LIPASE ROG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005412">
        <property type="entry name" value="UCP005412_abhydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="3">
        <location>
            <begin position="192"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ46511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="733" mass="82989" checksum="EBCD0D27244EFD7B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS27</accession>
    <name>C4YS27_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS27"/>
    <dbReference type="PaxDb" id="5476-C4YS27"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04885"/>
    <dbReference type="HOGENOM" id="CLU_063721_0_0_1"/>
    <dbReference type="OMA" id="ENWCNIL"/>
    <dbReference type="OrthoDB" id="286814at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000359">
        <property type="entry name" value="Cyclin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF36">
        <property type="entry name" value="PHO85 CYCLIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="102"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="304" mass="35401" checksum="004EB5DA5D15D9BA" modified="2009-07-28" version="1">MQSPTSPVSYKETSVPSFSKESTTTETSKSLPHANLLTPPTLTPPTITSDLPTSTLSPNHHNYYTHYLNKAQFNSILVNCSINLLKILYKNQKFDEKSIKLFIIEILRRSKTSIQSLQLSCFYIYKLIVAKQKITFDAKKLFLGLIIISSKFNQDYNYSFKSWCKICGLNENSNVKQLVHIESTILQWLNYDLCLIGSKYENWCNLLLIFGYDFIQYQLIFDNRTEIFWNQEIKDKINSWQSFFNQLNLDNLNIINVNFNNYFNNQLNKKVFVVKDEQPTLLSKKRSSTSLFDTEQPVAKKVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSA3</accession>
    <name>C4YSA3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSA3"/>
    <dbReference type="PaxDb" id="5476-C4YSA3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04965"/>
    <dbReference type="HOGENOM" id="CLU_460026_0_0_1"/>
    <dbReference type="OMA" id="PANFYYD"/>
    <dbReference type="OrthoDB" id="3981301at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="505"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="593" mass="64269" checksum="C87BB515F90D4299" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSG4</accession>
    <name>C4YSG4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b-c1 complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_05030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the UQCRB/QCR7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSG4"/>
    <dbReference type="SMR" id="C4YSG4"/>
    <dbReference type="PaxDb" id="5476-C4YSG4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05030"/>
    <dbReference type="HOGENOM" id="CLU_115154_1_0_1"/>
    <dbReference type="OMA" id="PLAQWYT"/>
    <dbReference type="OrthoDB" id="425749at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1090.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1090.10">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003197">
        <property type="entry name" value="QCR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036544">
        <property type="entry name" value="QCR7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02271">
        <property type="entry name" value="UCR_14kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000022">
        <property type="entry name" value="Bc1_14K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81524">
        <property type="entry name" value="14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ46667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="127" mass="14424" checksum="755D527CF3234865" modified="2010-10-05" version="1">MVQSMTSVVKAANFILARPTLSKIITPLAQKFTAYAGYREMGLKFNDLLLEETPIMQTAIKRLPSELNYSRNFRILTAHQLALSHQLLPAEKAVKPEEDDNYLIPYILEAEKEAFEKAELDNIEVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSQ3</accession>
    <name>C4YSQ3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_05121</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SRP72 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSQ3"/>
    <dbReference type="PaxDb" id="5476-C4YSQ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05121"/>
    <dbReference type="HOGENOM" id="CLU_013808_1_0_1"/>
    <dbReference type="OMA" id="ELACNER"/>
    <dbReference type="OrthoDB" id="5421607at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:002210">
        <property type="entry name" value="Signal recognition particle subunit SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031545">
        <property type="entry name" value="SRP72_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17004">
        <property type="entry name" value="SRP_TPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038922">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0733">Signal recognition particle</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="591"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="612"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR038922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ46756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="633" mass="71387" checksum="320EBD6C159B6875" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSQ9</accession>
    <name>C4YSQ9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_05127</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="4"/>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSQ9"/>
    <dbReference type="PaxDb" id="5476-C4YSQ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05127"/>
    <dbReference type="HOGENOM" id="CLU_037162_0_2_1"/>
    <dbReference type="OMA" id="YSHAKMY"/>
    <dbReference type="OrthoDB" id="10249612at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="302"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ46762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="463" mass="52899" checksum="9F91A8E74DB1F426" modified="2009-07-28" version="1">MIRSITRIMSHSIHSSVKDIQKDMYFGTEVLNRVSFLREDPEFIQSSLFHPSTRFIFYYKQQPLIHKNFDNKLCVLTNGSNQAVIDNVDNGKLGYSGKKAIIQSGLIDNIPQWQEILTNWYNDNKNHDKNLRAKGKPIFLFMGLLDESVGLNLQSLKFAADTKEETYLDHQGRYQGIAYYAVDLSSAKELTENLINFVNDSINKLHDNPNGTPDSNGIFFTHSRKHYLGFEQKEASLYSQGAMLFSWLNTNKFCPGCGEPTIPIYAGGKLFCTNEKKRSEEDDDRYACPVKSARVSNASFPRTDMAVISVITNEDRSKILLSLNKRYAIARMYTCTAGFMEPSETIEVATRREIWEETGVTCDEINIIMTQPWPFPQNLMIGCRGIVEFNGKNEIIHLGHDNELEDARWFDTSFVRKLVYPDEVTADEKDSFNPENIIIPMSESIAFSLIKLVVDEAKNQHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSR4</accession>
    <name>C4YSR4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_05133</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSR4"/>
    <dbReference type="PaxDb" id="5476-C4YSR4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05133"/>
    <dbReference type="HOGENOM" id="CLU_019279_2_7_1"/>
    <dbReference type="OMA" id="IFDWTFL"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000159">
        <property type="entry name" value="Casein kinase I hhp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="9"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="303"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="343"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="381"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ46767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="431" mass="50181" checksum="B16619A68F2DAB1D" modified="2009-07-28" version="1">MDLRVGKKYRIGRKIGSGSFGDIYLGTNIISGEEVAIKLENTKAKHPQLEYEAKVYKALSGGVGIPFVRWYGTECDYNAMVIDLLGPSLEDLFNYCNRKFTYKTVLLLADQLICRIEYIHARCFIHRDIKPDNFLMGIGRRGSQVNVIDFGLAKKYRDPRTHLHIPYRENKNLTGTARYASVNTHLGIEQSRRDDLESLGYVLIYFCRGSLPWQGLKAATKRQKYDRIMEKKMTTPNNILCKGLPSEFLEYMNYVKTLRFDDKPDYPYLRKLFRDLFKKENYRYDYVFDWTLYKFQQEKQRAQQGKVADGDNQDQQQQQNNQNQTQTQNQQGQITAPQPPVPVSQQQQQQQIPQHIPTPQQISQQQSQQSQQQQLPQQQQKTSVTPQLQQYTDQRLQNQRAVYQSNQNYSGTKSAQPQAQQPPQQGNPAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSS6</accession>
    <name>C4YSS6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small COPII coat GTPase SAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Small COPII coat GTPase sar1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAWG_05145</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSS6"/>
    <dbReference type="PaxDb" id="5476-C4YSS6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05145"/>
    <dbReference type="HOGENOM" id="CLU_040729_6_0_1"/>
    <dbReference type="OMA" id="GLWNKHG"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00879">
        <property type="entry name" value="Sar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000161">
        <property type="entry name" value="Small COPII coat GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 18" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="91"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEQ46779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="152" mass="17056" checksum="560FCCE387D16DE2" modified="2009-07-28" version="1">MLKNDRLATLQPTLHPTSEELAIGSVRFTTFDLGGHQQARRLWKDYFPEVNGIVFLVDAADTERFAESKAELESLFRIEELSQVPFVILGNKIDVPTAVGEMELKNALGLYNTTGKDTGKLPEGTRPIEVFMVSVVMRSGYGEAFKWLSQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSV3</accession>
    <name>C4YSV3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_05172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSV3"/>
    <dbReference type="PaxDb" id="5476-C4YSV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05172"/>
    <dbReference type="HOGENOM" id="CLU_043057_0_0_1"/>
    <dbReference type="OMA" id="WSENAEQ"/>
    <dbReference type="OrthoDB" id="5328412at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="531" mass="60768" checksum="B7B23EEDA33B5E6F" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSX2</accession>
    <name>C4YSX2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSX2"/>
    <dbReference type="PaxDb" id="5476-C4YSX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05667"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="OMA" id="LCIWKQI"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13994">
        <property type="entry name" value="STKc_HAL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001476">
        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="318" mass="36764" checksum="F46F5861929FA4DA" modified="2009-07-28" version="1">MMGFKKIFKVENQNSEYKFSRNDIKSSQLGKGITGSVDLYQSKTLPRFQYAVKTYHTKDIHESKKDYKTRVLYEYLILSKLSHCNIIKIYDYDVSFSGSTIKLFLELGTANLNQLIIKQTNTFNINEMLCIWKQITNAVNYLHELDICHRDLKLENVVFDVNYKLIKVIDFATAQKLNNNELSRGLVGSESYTAPETYSSIQYDGKSSDVWSLGIILCYLINKKQPWKSAMWSNSDYQQFINQDNFSQEPYFVDFPVESLLLTSQILEQDPLRRIKINDFFSDKWFSLIQYCGCGVAGGGIDNKTCGIDHGKSFRVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT04</accession>
    <name>C4YT04_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SnoRNA-binding rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bystin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT04"/>
    <dbReference type="PaxDb" id="5476-C4YT04"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05701"/>
    <dbReference type="HOGENOM" id="CLU_029727_0_1_1"/>
    <dbReference type="OMA" id="TKLPVIW"/>
    <dbReference type="OrthoDB" id="2192561at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007955">
        <property type="entry name" value="Bystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821:SF0">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05291">
        <property type="entry name" value="Bystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ47140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="54728" checksum="BB3A10A83B1A6D36" modified="2009-07-28" version="1">MGKITTSDTKTKQRHNPLLKDISSQGGNLRTVPRSSSSSSSQKKKSSKKQRHNDEDDEENGGGEGFLDASSSRKILQLAKEQQDELEQEDEIQNKPSFAQSFKNQQIDSEEEEEEDEYSDFEEEEEVEEIVYDEEDAEVDPKDAELFNKYFQSNGENNNNNNNDDSFQPTINLADKILAKIQEKESQQQQQQQQSSPDNSNENAVLLPPKVILAYEKIGQILSTYTHGKLPKLFKILPSLKNWQDVLYVTNPNSWTPHATYEATKLFVSNLSSNEATVFIETILLPRFRDSIENSDDHSLNYHIYRALKKSLYKPGAFFKGFLLPLVDGYCSVREATIAASVLTKVSVPVLHSSVALTQLLTRDFNPATTVFIRVLIEKKYALPYQTLDELVFYFMRFRNATINQDENMENMDIDQEKTTKVNNGPQLPVVWHKAFLSFATRYKNDLTDDQKDFLLETVRQRFHPLIGPEIRRELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT36</accession>
    <name>C4YT36_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_05734</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT36"/>
    <dbReference type="SMR" id="C4YT36"/>
    <dbReference type="PaxDb" id="5476-C4YT36"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05734"/>
    <dbReference type="HOGENOM" id="CLU_043579_1_0_1"/>
    <dbReference type="OMA" id="ARSREHN"/>
    <dbReference type="OrthoDB" id="1507364at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000070">
        <property type="entry name" value="Endoplasmic reticulum protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="23"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ47172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="331" mass="37123" checksum="1250EDFCF0D326F3" modified="2010-10-05" version="1">MSSSYTKEQESIVLKVLSYKPHQFYEILSVEKSASEGEIKKSYRKLAIKCHPDKNPHPRSSEAFKILNKAWEVLSDPQKKRIFDQTGSDPTSRINNASAASGGFPSSSFSGRSGFANNPFEDDLFNMFFGGGGGPRGSPFASGPTFTFGGNGFTFQSYGNGGADPFMRYRRTTRRPRAQSPNGREQTGPNGEEQPSLFEALKGILPILMLLIVPILSAIFSGDTSPEYSFVPSQEYNIQRNTPKYNIPFYVTDKFQEKHGSKSKRQLRNYDSKVENLFISDKRAKCSKEQIHKDQLIEDAYGWFSVDSEKLQRAENFPTPNCDILKGLNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTF0</accession>
    <name>C4YTF0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
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                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="17"/>
        </location>
    </feature>
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            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ42146.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="278" mass="31201" checksum="7D3515A53FB2C848" modified="2009-07-28" version="1">MKLSAVIFLGSLSLTQATGWYPVNSKQEIPSEIVPYTKGQEVSFGCIQRNIDNGEHKFDEKENIIYGPFPTCKETGKPLAFKYGINEDINCTIQFTDELYHLFQLYLHEDAPFSCRLPLSSDVLSIEKGGASIPLTFNIRGALSESHIDIDNSMNVLITKPANNDPNQFTFVSAIAYGAGTNTTRAVIGDQVTMTFAVRWLDQLSPVNSNGGQKLPYQDGFYRFPTSFVPISYSLFYFYLLLTSFISGIAVIAFSYKWISLKITKHKYMPVDDESKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDA7</accession>
    <name>C4YDA7_CANAW</name>
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        <recommendedName>
            <fullName evidence="4">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
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                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EEQ42293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OMA" id="YRYEYYY"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RGS_sf"/>
    </dbReference>
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        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
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    </feature>
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            <end position="557"/>
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    </feature>
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            <end position="352"/>
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        <location>
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            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="61348" checksum="244FE641185DB427" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDD1</accession>
    <name>C4YDD1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="15">NAD-dependent histone deacetylase SIR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_00524</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
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                <person name="Santos M.C."/>
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                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
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                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
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                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="3">Belongs to the sirtuin family. Class I subfamily.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
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        <property type="entry name" value="Sirtuin"/>
    </dbReference>
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        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
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        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF592"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
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        <location>
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            <end position="468"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
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    </feature>
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    </feature>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
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        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="417"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ42317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="468" mass="53141" checksum="0A733C5E2A7A4572" modified="2009-07-28" version="1">MPGDNDIVLVDSSSDNEEEREDDDDDESQHREIKKFKPNPNPSQTRDMNESHVVNKSNFSTVPFNAVSSSSSSDNDQDNDEEEEEEEESEINGNQISLSIDDEYDSEGLTKESSRTPIGSNTSDIIINGVTIITNNNDSSLVALSSSDDDDDDDDKDDDKDDDNDDDASDLESDFAFEEISPSLIMETRKYLKQNGTMKFLEKYLPTAASIENIIKLILQLGFVPKRKLNNGLDENDIMEYIKILNHAIIKVKSIRERREDITTINDVLKLIENSKNIMVITGAGISTSLGIPDFRSSQGFYSMIQHLGLSDPQEVFDLDLFLNDPNIFYSIAHMILPPNQIYSPLHSFIKLLQDKNKLLRNYTQNIDNLESYAGIHKENLIQCHGSFATASCITCGYKVDGEIIFPEIKNKEIPYCPKCNEVKQSILKKGKKTKSKSKKKKKKKNKPYMMTRKRKREKLIFMKVLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDH6</accession>
    <name>C4YDH6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_00571</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDH6"/>
    <dbReference type="SMR" id="C4YDH6"/>
    <dbReference type="PaxDb" id="5476-C4YDH6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00571"/>
    <dbReference type="HOGENOM" id="CLU_1156246_0_0_1"/>
    <dbReference type="OMA" id="VQENYIR"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="161"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="161"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ42362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="245" mass="28486" checksum="B2B19B7C2CBEDAA6" modified="2010-10-05" version="1">MLRSFVTSISPIGYNAVSLVSMRALATKAATTTTKKSTTKASPKTKKTTKKSTKPPKVDTKAIRLQKKINEARSAKKNLQQQIKDISTQHKTLSKQRKFEEKARSKIHKLAPGNFYSMFQKKRAGDSVAEFYQFPEEEKAKWIAARDAYWEKAKSYFTPKPKLGANGFAKYVQENYIRGDSLTETMKKLADEWNALSETEKQQYQISKEDKEKYKKALEKWKELRLKEYSDYLKFKENYKVEDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDX7</accession>
    <name>C4YDX7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein HMF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDX7"/>
    <dbReference type="PaxDb" id="5476-C4YDX7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00725"/>
    <dbReference type="HOGENOM" id="CLU_100715_7_3_1"/>
    <dbReference type="OMA" id="PAKFSHG"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="137" mass="15091" checksum="607318A17E083E7C" modified="2009-07-28" version="1">MFANKLSSQSFRSVIMSAKRFNSTITPVCFIYVSGQIPYTPDNKPLPASATIADYAEQAIQNVSNILEASNSSLNHIVKANIFLTDMGAQFGEFNKVYAKYFSEHKPARSCVAVKELPLGVPLEIEVVAIEKDDTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YE43</accession>
    <name>C4YE43_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear protein localization protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_00796</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NPL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YE43"/>
    <dbReference type="PaxDb" id="5476-C4YE43"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00796"/>
    <dbReference type="HOGENOM" id="CLU_017172_0_0_1"/>
    <dbReference type="OMA" id="TKDRYVP"/>
    <dbReference type="OrthoDB" id="10251089at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08061">
        <property type="entry name" value="MPN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016563">
        <property type="entry name" value="Npl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007717">
        <property type="entry name" value="NPL4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024682">
        <property type="entry name" value="Npl4_Ub-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007716">
        <property type="entry name" value="NPL4_Zn-bd_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710:SF0">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05021">
        <property type="entry name" value="NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11543">
        <property type="entry name" value="UN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05020">
        <property type="entry name" value="zf-NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010052">
        <property type="entry name" value="Polyub_prc_Npl4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MPN" evidence="12">
        <location>
            <begin position="259"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ42579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="593" mass="66939" checksum="0866E62B7627D5BD" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEA5</accession>
    <name>C4YEA5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_00860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEA5"/>
    <dbReference type="PaxDb" id="5476-C4YEA5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00860"/>
    <dbReference type="HOGENOM" id="CLU_072440_3_0_1"/>
    <dbReference type="OMA" id="SAWGKQH"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000159">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF39">
        <property type="entry name" value="PEROXISOMAL MEMBRANE ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="25"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ42641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="184" mass="20120" checksum="DF448B73292F8DAF" modified="2009-07-28" version="1">MFSFTRAVPKSQLRFTVRNSLRTYVSIGDKVPATPVFEGSPGNDINLAEETASGKTILIGVPGAFSPACSASHVPGYIKNIRAFNDKGYQRFFVVAVNDPFVTKAWGEQLLESVAGQQIRFFADSTGAFTKELDLLFDARKAFGNERSKRYALIIEDGKVVKSFVEPDNTSVDVSAAQKVLEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEK1</accession>
    <name>C4YEK1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_00958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="C4YEK1"/>
    <dbReference type="PaxDb" id="5476-C4YEK1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00958"/>
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    <dbReference type="OMA" id="NLWDINK"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="entry name" value="UIM_dom"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
    </feature>
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            <end position="104"/>
        </location>
    </feature>
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        <location>
            <begin position="159"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="422"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ42737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="606" mass="69219" checksum="40423F9D5015EA1F" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEL7</accession>
    <name>C4YEL7_CANAW</name>
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        <recommendedName>
            <fullName evidence="10">GPI inositol-deacylase</fullName>
            <ecNumber evidence="10">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_00974</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="10"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
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        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="11">
        <location>
            <begin position="108"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006931"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="390" mass="44325" checksum="FC626E0B3230B55D" modified="2009-07-28" version="1">MLSKRLFPYSNLFPRSRKYKFIVYFIICLTIIISALGVYLYSIPIVSPNQPQCDMVWMSPSYARIRAFDETHTKYASKYNLYLYREQDVDKMPNENENEDGNEGFTSLDGIPALFIHGNAGSFEQVRSIAARCSEMYYTDGKFKEKYPHARNIDFFTADFNEELSAFKGLRDQVEYVTQAISFIVDLYPQNPNRNIILIGHSMGGLVARIAASRQQHESNVDIILTLATPHSDPFPWLPKTSDFPDEVGLISIYSSVDLMVPPSVVTPKSKSDHFFSVDAAKLLGVPIDHQGIVWCGQLREKLSEALIGISGLNTLQDRMKVFKKIFSGDRKELGPTPIFGLAKLKLKLLQSWVHLLSLTIFALKWTIIVLAIIQLRKVYTKFNNPPPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEX0</accession>
    <name>C4YEX0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein HID1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="IFEDDKW"/>
    <dbReference type="OrthoDB" id="432953at2759"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:Golgi trans cisterna"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1051" mass="118727" checksum="FB4D22A682612290" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEY7</accession>
    <name>C4YEY7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial intermembrane space import and assembly protein 40</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Mitochondrial import inner membrane translocase TIM40</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CAWG_01096</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
            <orientation evidence="3">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEY7"/>
    <dbReference type="PaxDb" id="5476-C4YEY7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01096"/>
    <dbReference type="HOGENOM" id="CLU_054990_1_0_1"/>
    <dbReference type="OMA" id="CFKRYPE"/>
    <dbReference type="OrthoDB" id="7481291at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2900:FF:000002">
        <property type="entry name" value="Mitochondrial intermembrane space import and assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039289">
        <property type="entry name" value="CHCHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622:SF0">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="13" id="KW-0811">Translocation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CHCH" evidence="20">
        <location>
            <begin position="162"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="90"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00033150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EEQ42873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="251" mass="27882" checksum="2DB6A5C17A30506F" modified="2009-07-28" version="1">MYRTISRSSSGLIRQSTARLTRQFSTTRTTPSQYNSKLLLGVLGTGALAFGYFSQQSSLIQNASTAENIEKVFEEGNAVAKDAQESLDARQEKVIKENEQKTKKAEDAKTSESKANVADKKSDSQTEGEPEGEGKQEAAFNPDTGEINWDCPCLGGMAHGPCGEEFKEAFSCFVFSETEPKGIDCIKKFENMRSCFKRYPEHYKDELYDDGEEEASTEVVEHVVLETSEPAIEQIEQGIKEDKVKPNTKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEY8</accession>
    <name>C4YEY8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ypt7p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_01097</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEY8"/>
    <dbReference type="SMR" id="C4YEY8"/>
    <dbReference type="PaxDb" id="5476-C4YEY8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01097"/>
    <dbReference type="HOGENOM" id="CLU_041217_10_0_1"/>
    <dbReference type="OMA" id="ERCIDHE"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ42874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="32059" checksum="A31254AD6EEDB79A" modified="2010-10-05" version="1">MSKHRLTNNKNNTNGISKPSSNSVSVENSSTNNPKAGPTPTLKVVLLGDSGVGKTCLRSQFVHHVFTNAYKATIGGDYLTTSVVLPQQIQQSQLSSSTSSLDIKSNFATTRLPSTNTKVNLQIWDTAGQERFNSISQAFYRGTDVCVLVYDVTNYESVLSIRDWFNRFMEHCHVEFPGIVIVGNKSDKSTDRCVDLNEIKDIVTTNTTFANVGDYIDDWDNSLMEISAKRLELVEELFVRVAKIGVDLLMGNKGDNKRRLQQFDKIDLRETHNRINDNTTSTSSSCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF27</accession>
    <name>C4YF27_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="8">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_01138</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF27"/>
    <dbReference type="PaxDb" id="5476-C4YF27"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01138"/>
    <dbReference type="HOGENOM" id="CLU_013809_0_1_1"/>
    <dbReference type="OMA" id="RCCAYSP"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000596">
        <property type="entry name" value="Eukaryotic translation initiation factor 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="10">
        <location>
            <begin position="221"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="455"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="491"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="558"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ42913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="643" mass="71092" checksum="D3CA5266ED6FEA4A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF39</accession>
    <name>C4YF39_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L26-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_01150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF39"/>
    <dbReference type="SMR" id="C4YF39"/>
    <dbReference type="PaxDb" id="5476-C4YF39"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01150"/>
    <dbReference type="HOGENOM" id="CLU_093240_0_1_1"/>
    <dbReference type="OMA" id="VRIMRGD"/>
    <dbReference type="OrthoDB" id="1688503at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000009">
        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ42925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="127" mass="14185" checksum="CF9CB3FAEE3B597E" modified="2009-07-28" version="1">MAKISQDVSSSRSKARKAYFTASSVERRVLLSAPLSKELRQQYNVKSLPIRQNDEVLVVRGSKKGSEGKVNSVYRLKFAIQVDKLQKEKSNGASVPINIHPSKVVITKLHLDKDRKALIQRKGGKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF61</accession>
    <name>C4YF61_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_01173</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF61"/>
    <dbReference type="PaxDb" id="5476-C4YF61"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01173"/>
    <dbReference type="HOGENOM" id="CLU_001485_2_3_1"/>
    <dbReference type="OMA" id="SFWSHNT"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000260">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="3">
        <location>
            <begin position="4"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="467"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="112"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ42947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="538" mass="61228" checksum="D0E5F473AFFC3185" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF98</accession>
    <name>C4YF98_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">IMP-specific 5'-nucleotidase 1</fullName>
            <ecNumber evidence="4">3.1.3.99</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_01212</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>IMP + H2O = inosine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27718"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="3.1.3.99"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ISN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.99" evidence="4"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF98"/>
    <dbReference type="PaxDb" id="5476-C4YF98"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01212"/>
    <dbReference type="HOGENOM" id="CLU_031816_0_0_1"/>
    <dbReference type="OMA" id="HDDGANF"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006190">
        <property type="term" value="P:inosine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071590">
        <property type="term" value="P:nicotinamide riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071592">
        <property type="term" value="P:nicotinic acid riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009453">
        <property type="entry name" value="ISN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213:SF1">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06437">
        <property type="entry name" value="ISN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ42984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="331" mass="37302" checksum="1829C3CDA056B386" modified="2009-07-28" version="1">MILNTAQIMALTNIYKQTENNTNGISGKNQQQQQQKLKLITFDGDVTLYEDGKSLDENSEVVQRLVKLLSLGLYVGVVTAAGYPRQSGAEKYYERLKGLIDHLNSNHCTLKTYQKENLLVMGAESNYLFRYNNEMKGLKFIDDEEWFLPQVKNWNIGKINYIMDTLYKHLIYLRNNFNLEDSTTIIKKERSVGIIPNSGCRILREQLEEMVLSCSRKLNTILTSSSNFADSTEALCVDDIKVCAFNGGSDVWVDIGDKALGVESLQKYICHDETVDHVCPIGKSESLHIGDQFASLGANDFKARLSACTVWIASPRETVAILDDLIDFIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFA9</accession>
    <name>C4YFA9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_01224</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFA9"/>
    <dbReference type="SMR" id="C4YFA9"/>
    <dbReference type="PaxDb" id="5476-C4YFA9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01224"/>
    <dbReference type="HOGENOM" id="CLU_006406_6_2_1"/>
    <dbReference type="OMA" id="YEFKWER"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07956">
        <property type="entry name" value="Anticodon_Ia_Arg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.70:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000058">
        <property type="entry name" value="Mitochondrial arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginyl tRNA synthetase N-terminal" evidence="13">
        <location>
            <begin position="32"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="DALR anticodon binding" evidence="12">
        <location>
            <begin position="505"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ42995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="622" mass="70793" checksum="C7567B323EAA05AB" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFI3</accession>
    <name>C4YFI3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="13">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_01301</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="4275" last="4275">
            <title>Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents.</title>
            <authorList>
                <person name="Juvvadi P.R."/>
                <person name="Fox D."/>
                <person name="Bobay B.G."/>
                <person name="Hoy M.J."/>
                <person name="Gobeil S.M.C."/>
                <person name="Venters R.A."/>
                <person name="Chang Z."/>
                <person name="Lin J.J."/>
                <person name="Averette A.F."/>
                <person name="Cole D.C."/>
                <person name="Barrington B.C."/>
                <person name="Wheaton J.D."/>
                <person name="Ciofani M."/>
                <person name="Trzoss M."/>
                <person name="Li X."/>
                <person name="Lee S.C."/>
                <person name="Chen Y.L."/>
                <person name="Mutz M."/>
                <person name="Spicer L.D."/>
                <person name="Schumacher M.A."/>
                <person name="Heitman J."/>
                <person name="Steinbach W.J."/>
            </authorList>
            <dbReference type="PubMed" id="31537789"/>
            <dbReference type="DOI" id="10.1038/s41467-019-12199-1"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 54-445 IN COMPLEX WITH FE(3+) AND ZN(2+)</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="13"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PDB" id="6TZ6">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.55 A"/>
        <property type="chains" value="A/D=54-445"/>
    </dbReference>
    <dbReference type="PDBsum" id="6TZ6"/>
    <dbReference type="AlphaFoldDB" id="C4YFI3"/>
    <dbReference type="SMR" id="C4YFI3"/>
    <dbReference type="PaxDb" id="5476-C4YFI3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01301"/>
    <dbReference type="HOGENOM" id="CLU_004962_6_0_1"/>
    <dbReference type="OMA" id="YPAACNF"/>
    <dbReference type="OrthoDB" id="5593063at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="18" id="KW-0002">3D-structure</keyword>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="15">
        <location>
            <begin position="196"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="438"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="470"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEQ43064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PDB" id="6TZ6"/>
        </source>
    </evidence>
    <sequence length="609" mass="69624" checksum="76983B3F4F4BEDFC" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFJ6</accession>
    <name>C4YFJ6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation factor Tu</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_01314</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">G-protein that, in its active GTP-bound form, binds to and delivers aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. In the presence of a correct codon-anticodon match between the aminoacyl-tRNA and the A-site codon of the ribosome-bound mRNA, the ribosome acts as a GTPase activator and the GTP is hydrolyzed. The inactive GDP-bound form leaves the ribosome and must be recycled before binding another molecule of aminoacyl-tRNA. Required for mitochondrial protein biosynthesis and maintenance of mitochondrial DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="10">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFJ6"/>
    <dbReference type="PaxDb" id="5476-C4YFJ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01314"/>
    <dbReference type="HOGENOM" id="CLU_007265_0_0_1"/>
    <dbReference type="OMA" id="EGDKEWG"/>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03707">
        <property type="entry name" value="EFTU_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000001">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000003">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF36">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="34"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ43077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="426" mass="46720" checksum="3FA7BE09E581D5C7" modified="2009-07-28" version="1">MLKTLTQTLRLTGKAFPKVRPALIRTYAAFDRSKPHVNIGTIGHVDHGKTTLTAAITKVLAEQGGANFLDYGSIDRAPEERARGITISTAHVEYETKNRHYAHVDCPGHADYIKNMITGAAQMDGAIIVVAATDGQMPQTREHLLLARQVGVQDLVVFVNKVDTIDDPEMLELVEMEMRELLSTYGFDGDNTPVIMGSALMALEDKKPEIGKEAILKLLDAVDEHIPTPSRDLEQPFLLPVEDVFSISGRGTVVTGRVERGILKKGEEIEIVGGFDKPYKTTVTGIEMFKKELDSAMAGDNCGVLLRGVKRDEIKRGMVLAKPGTATSHKKFLASLYILTSEEGGRSTPFGEGYKPQCFFRTNDVTTTFSFPEGEGVDHSQMIMPGDNIEMVGELIKSCPLEVNQRFNLREGGKTVGTGLITRIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFL5</accession>
    <name>C4YFL5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Survival factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_01333</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFL5"/>
    <dbReference type="PaxDb" id="5476-C4YFL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01333"/>
    <dbReference type="HOGENOM" id="CLU_030205_2_0_1"/>
    <dbReference type="OMA" id="AFWPRCV"/>
    <dbReference type="OrthoDB" id="2590239at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051385">
        <property type="entry name" value="Ceramide-binding_SVF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033394">
        <property type="entry name" value="Svf1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013931">
        <property type="entry name" value="Svf1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107:SF1">
        <property type="entry name" value="CERAMIDE-BINDING PROTEIN SVF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107">
        <property type="entry name" value="SVF1-LIKE PROTEIN YDR222W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08622">
        <property type="entry name" value="Svf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17187">
        <property type="entry name" value="Svf1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Svf1-like N-terminal" evidence="4">
        <location>
            <begin position="59"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Svf1-like C-terminal" evidence="5">
        <location>
            <begin position="220"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ43096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="382" mass="42999" checksum="DA47EF12CD36F11D" modified="2009-07-28" version="1">MLKWVQSGLSAVAGTAEPEYGPDAIQPITKRIFDTNNGKIYRATEPKDFEWLSPNYTNVETQTFYFTDLSNGNIGFAQIIHSNVMGLTTTAQFTFRLYNVKDKSINLWTSTKLEDFEIKDSNFYAKDLSLELKDNKVYKLKSSVNKESIVEFEMERLTDGVIFGDDGMSFYGEDPEQPWGSMRHVFWPRCKVNGTITTADNKVIEINNGLTMFVMALQGMKPHHAAKSWNFMNFQSANHSAVQMEFTTPKSYGTTKVNIGIVTDNEKILIASIDNQVVHSDTKFDDVGGWDVPQKIEFNYIDGKDKDKQVASVSGNLSQLVERVDVMAEIPQFVKNIVSGVAGARPYIYQYANEFTIDINNGDGEKVKEDGVGFTEVTFISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFT9</accession>
    <name>C4YFT9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP-sulfurylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Sulfate adenylate transferase</fullName>
            <shortName evidence="7">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MET3</name>
        <name evidence="10" type="ORF">CAWG_00065</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>sulfate + ATP + H(+) = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">Homohexamer. Dimer of trimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The oligomerization domain is distantly related to APS kinases, but it is not functional and does not bind APS. It is required for oligomerization of the enzyme, although the oligomerization state has no effect on the catalytic activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="7"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFT9"/>
    <dbReference type="PaxDb" id="5476-C4YFT9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00065"/>
    <dbReference type="HOGENOM" id="CLU_022950_1_0_1"/>
    <dbReference type="OMA" id="MEMRYAG"/>
    <dbReference type="OrthoDB" id="468at2759"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010134">
        <property type="term" value="P:sulfate assimilation via adenylyl sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004457">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000052">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.10">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03106">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027535">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050512">
        <property type="entry name" value="Sulf_AdTrans/APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700:SF1">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-sulfurylase PUA-like" evidence="9">
        <location>
            <begin position="5"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Sulphate adenylyltransferase catalytic" evidence="8">
        <location>
            <begin position="181"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Required for oligomerization; adenylyl-sulfate kinase-like" evidence="7">
        <location>
            <begin position="407"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="206"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="302"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="site" description="Induces change in substrate recognition on ATP binding" evidence="7">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00062002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ41878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="527" mass="58869" checksum="AAD9B89D7C078B2B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG15</accession>
    <name>C4YG15_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TMEM205-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_00130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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            <end position="37"/>
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            <end position="74"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ41939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="169" mass="18615" checksum="70A924FD59A9F5AF" modified="2009-07-28" version="1">MLCQVGLNVKVPFHFLFYSLTFGGSAFYSFIVSPLVFKKLPREEFSNLQNKVFPTYFTGQTLAPIILGLAQPFAYCPFTIGLLALSSVGGALNYLWLLPVCQKIKEDRNKLIADKKDVGADGQPTEELKALNKQFGKYHGISTLVNITSILSLGVYGVVLAKGLSKIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG16</accession>
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                <person name="Rasmussen M.D."/>
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                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
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                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
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                <person name="Kodira C."/>
                <person name="Lennard N."/>
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                <person name="Martin R."/>
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                <person name="Nikolaou E."/>
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                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
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                <person name="Skrzypek M.S."/>
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                <person name="Staggs R."/>
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                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
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                <person name="Berriman M."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946753" evidence="1">
        <location>
            <begin position="18"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ41940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="253" mass="29285" checksum="EB293A4D3BF6ECFA" modified="2009-07-28" version="1">MIIVWLIFSLFTSLCLSVSPDPNPSKIDRPILKISTRTHDKLIIINNLQEIANNISVGMTSYEKFNRLSSNEMRECVEGSCIKFYIREIKCTDRTFIASECRTNLNARFQSILQPTTNIHNLILRDEDSLDTQLKTNLVDHFSSFRQFKEFKFNDFNNNLNYDLQCLVDYQSLMQVHFKQTVVEVNLMRTTEVADACQFDKINPNFDGSRSVYTTTYLPVNGTFYCQKGKSQTCNRTIAESKNSRYKLPDICG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG31</accession>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
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                <person name="Fitzpatrick D.A."/>
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                <person name="Lennard N."/>
                <person name="Logue M.E."/>
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                <person name="Neiman A.M."/>
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                <person name="Shah P."/>
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                <person name="Stansfield I."/>
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                <person name="Berriman M."/>
                <person name="Heitman J."/>
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                <person name="Lorenz M.C."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:exocytosis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Rab11BD_RAB3IP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
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        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF0">
        <property type="entry name" value="SEC2P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="29"/>
            <end position="156"/>
        </location>
    </feature>
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        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="500"/>
        </location>
    </feature>
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        <location>
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            <end position="724"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="327"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
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        <location>
            <begin position="574"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="667"/>
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    </feature>
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        <location>
            <begin position="694"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ41955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="749" mass="85164" checksum="71E6684D7DD852C5" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG69</accession>
    <name>C4YG69_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 15">DNA replication licensing factor MCM4</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAWG_00187</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 21">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 15"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YG69"/>
    <dbReference type="SMR" id="C4YG69"/>
    <dbReference type="PaxDb" id="5476-C4YG69"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00187"/>
    <dbReference type="HOGENOM" id="CLU_000995_7_1_1"/>
    <dbReference type="OMA" id="AFFKCNV"/>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000011">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000217">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21128">
        <property type="entry name" value="WHD_MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="19" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="18">
        <location>
            <begin position="496"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="459"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEQ41993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="910" mass="102239" checksum="C646FC0BEEF99D80" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGB7</accession>
    <name>C4YGB7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_00238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGB7"/>
    <dbReference type="PaxDb" id="5476-C4YGB7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00238"/>
    <dbReference type="HOGENOM" id="CLU_120067_0_0_1"/>
    <dbReference type="OMA" id="KIANNLH"/>
    <dbReference type="OrthoDB" id="10534413at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ42041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="143" mass="16351" checksum="CED667F0E94A3C2A" modified="2009-07-28" version="1">MQDIINNQFLLLEFSYLDDEDDGDTGFTTVSHSTSRDSFFDIHGSDFTTSTSSQNNMGDKFKIANNLHSKSQKLAATIQKWCFKKFYKKSKVKSNESKKISIISKKLDNSNDKFVYFDQSTELERTSNIATEQSKKDNGNIMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGF4</accession>
    <name>C4YGF4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative peptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_03130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ZPS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGF4"/>
    <dbReference type="PaxDb" id="5476-C4YGF4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03130"/>
    <dbReference type="HOGENOM" id="CLU_048223_0_0_1"/>
    <dbReference type="OMA" id="CNATQRR"/>
    <dbReference type="OrthoDB" id="4689212at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11307">
        <property type="entry name" value="M35_Asp_f2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000043">
        <property type="entry name" value="Major allergen Asp F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029482">
        <property type="entry name" value="HRXXH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039124">
        <property type="entry name" value="PRA1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39399">
        <property type="entry name" value="PROTEIN ZPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39399:SF1">
        <property type="entry name" value="PROTEIN ZPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13933">
        <property type="entry name" value="HRXXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012700369" description="Putative peptidase domain-containing protein" evidence="5">
        <location>
            <begin position="16"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Putative peptidase" evidence="6">
        <location>
            <begin position="15"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="253"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ44836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="299" mass="33159" checksum="E87CDC177139C03D" modified="2010-10-05" version="1">MNYLLFCLFFAFSVAAPVTVTRFVDASPTGYDWRADWVKGFPIDSSCNATQYNQLSTGLQEAQLLAEHARDHTLRFGSKSPFFRKYFGNDTASAEVVGHFENVVGADKSSILFLCDDLDDKCKNDGWAGYWRGSNHSDQTIICDLSFVTRRYLTQLCSSGYTVSKSKTNIFWAGDLLHRFWHLKSIGQLVIEHYADTYEEVLELAQENSTYAVRNSNSLIYYALDVYAYDVTIPGEGCNGDGTSYKKSDFSSFEDSDSGSDSGASSTASSSHQHTDSNPSATTDANSHCHTHADGEVHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGF7</accession>
    <name>C4YGF7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">21S rRNA pseudouridine(2819) synthase</fullName>
            <ecNumber evidence="7">5.4.99.43</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pseudouridine synthase 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pseudouridylate synthase PUS5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Uracil hydrolyase PUS5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_03133</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Pseudouridylate synthase responsible for the pseudouridine-2819 formation in mitochondrial 21S rRNA. May modulate the efficiency or the fidelity of the mitochondrial translation machinery.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>uridine(2819) in 21S rRNA = pseudouridine(2819) in 21S rRNA</text>
            <dbReference type="Rhea" id="RHEA:42556"/>
            <dbReference type="Rhea" id="RHEA-COMP:10113"/>
            <dbReference type="Rhea" id="RHEA-COMP:10114"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.43"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.43" evidence="7"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGF7"/>
    <dbReference type="PaxDb" id="5476-C4YGF7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03133"/>
    <dbReference type="HOGENOM" id="CLU_998077_0_0_1"/>
    <dbReference type="OMA" id="CIITKIG"/>
    <dbReference type="OrthoDB" id="428658at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160143">
        <property type="term" value="F:21S rRNA pseudouridine(2819) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF81">
        <property type="entry name" value="21S RRNA PSEUDOURIDINE(2819) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="12">
        <location>
            <begin position="11"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ44839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="274" mass="31283" checksum="D1749FB4C23FDF8B" modified="2009-07-28" version="1">MKLDLVKRTFNYAVVNKPSGMVCDASHTNNIITALTNEFTKILPSVNSSQFRLVQRLDRFVTGGLVVARNKKWADKVRKSFFQEGTLRLTRRYVGLIALDQIPESTQGTIDFPIQALEKDYRGKNKSRELFTYSAVTHYKLIPSARRTIKGVFPVFQQGPILPIILELETGRKNQIRDHIIQKFGVPLLNDDNFSDFKLNPEIPKDVNSKSYKSNQIALHSGLVIMENNGISQQFLFPVNNAYDRELWGSFVNEKGEFIDEIRNGLINFKIQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGP2</accession>
    <name>C4YGP2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA repair protein REV1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Reversionless protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAWG_03223</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Involved in mitochondrial DNA mutagenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGP2"/>
    <dbReference type="PaxDb" id="5476-C4YGP2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03223"/>
    <dbReference type="HOGENOM" id="CLU_003901_1_0_1"/>
    <dbReference type="OMA" id="PPKYMGM"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17719">
        <property type="entry name" value="BRCT_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000016">
        <property type="entry name" value="DNA damage repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000001">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000011">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="17">
        <location>
            <begin position="143"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="18">
        <location>
            <begin position="392"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="883"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEQ44924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1113" mass="128235" checksum="CB8D08A79E380C10" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGX7</accession>
    <name>C4YGX7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome assembly protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Notchless protein homolog 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ribosome biogenesis factor RSA4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_03315</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NLE1/RSA4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGX7"/>
    <dbReference type="PaxDb" id="5476-C4YGX7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03315"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_16_1"/>
    <dbReference type="OMA" id="AWEPYHR"/>
    <dbReference type="OrthoDB" id="10267436at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000092">
        <property type="entry name" value="notchless protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="10">
        <location>
            <begin position="32"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="141"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="184"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="227"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="276"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="402"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="444"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="486"/>
            <end position="519"/>
        </location>
    </feature>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YH90"/>
    <dbReference type="PaxDb" id="5476-C4YH90"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03435"/>
    <dbReference type="HOGENOM" id="CLU_665906_0_0_1"/>
    <dbReference type="OMA" id="TWGCRWN"/>
    <dbReference type="OrthoDB" id="416496at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000371">
        <property type="entry name" value="Methyltransferase OMS1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050508">
        <property type="entry name" value="Methyltransf_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912:SF83">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Methyltransferase" evidence="10">
        <location>
            <begin position="252"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ45122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="444" mass="52126" checksum="9909FF7B6A2D7314" modified="2009-07-28" version="1">MLGQRMILRNTYRLTVPKSVILPICRTNYSTSSSSNNPFPLNDKERKQAKKQSQLPWYKRWTNYSNSEQFQNKTMPKVYICAFVVSLVPMYFYMRDRYHEDKQLKHINAKYAQDPSSLSEYEYLVLKSMNHSEKLRPLELKKYKIYQLMRKEFRRKNLFNQEMFNPTPQELNDWYQNQVKYESASKVVPILVDKIDSKDKINANPAIQNAEDTTAFYDSKAKEYDDAVKWEERGIFMGSKRKWLMSQAKGDVLEVSCGTGRNIPYLYLQQIKSLTFIDSARNMVEVTKKKFKKAFPEFKKVAFAVGKAEDLSNIAQDVKYDTIVEAFGLCCHEDPVKALQNMAKLLKPGGRIVLLEHGRSNWGFINNHLDFRSEKRMETWKCRWNLDIGELIDEAGLDITKEKRAHFSTTWMVVVKKPEDPINPDEKPFLDKLFGRESRKVQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHD1</accession>
    <name>C4YHD1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">XPG-I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_03477</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPG/RAD2 endonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHD1"/>
    <dbReference type="PaxDb" id="5476-C4YHD1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03477"/>
    <dbReference type="HOGENOM" id="CLU_378548_0_0_1"/>
    <dbReference type="OMA" id="RFYQTKV"/>
    <dbReference type="OrthoDB" id="17262at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09858">
        <property type="entry name" value="PIN_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022039">
        <property type="entry name" value="MKT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022040">
        <property type="entry name" value="MKT1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF32">
        <property type="entry name" value="POST-TRANSCRIPTIONAL REGULATOR MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12246">
        <property type="entry name" value="MKT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12247">
        <property type="entry name" value="MKT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="XPG-I" evidence="4">
        <location>
            <begin position="157"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="397"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ45163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="895" mass="101715" checksum="B70DE1FD16835DAF" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHG9</accession>
    <name>C4YHG9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="12">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_03515</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="12"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHG9"/>
    <dbReference type="PaxDb" id="5476-C4YHG9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03515"/>
    <dbReference type="HOGENOM" id="CLU_003041_26_1_1"/>
    <dbReference type="OMA" id="YDKMFER"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17941">
        <property type="entry name" value="DEADc_DDX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="79"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="267"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="655"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="655"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="720"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ45201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="765" mass="86664" checksum="62DBF246ECD0F4AE" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHI3</accession>
    <name>C4YHI3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-trimethyl-L-lysine(9) demethylase</fullName>
            <ecNumber evidence="2">1.14.11.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_03529</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:60200"/>
            <dbReference type="Rhea" id="RHEA-COMP:15538"/>
            <dbReference type="Rhea" id="RHEA-COMP:15542"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.66"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the JHDM3 histone demethylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.66" evidence="2"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHI3"/>
    <dbReference type="PaxDb" id="5476-C4YHI3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03529"/>
    <dbReference type="HOGENOM" id="CLU_001442_1_2_1"/>
    <dbReference type="OMA" id="IPIQRCV"/>
    <dbReference type="OrthoDB" id="9547406at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140684">
        <property type="term" value="F:histone H3K9me2/H3K9me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000038">
        <property type="entry name" value="Transcriptional repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF7">
        <property type="entry name" value="[HISTONE H3]-TRIMETHYL-L-LYSINE(9) DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13771">
        <property type="entry name" value="zf-HC5HC2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="8">
        <location>
            <begin position="22"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="9">
        <location>
            <begin position="180"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="427"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ45215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="608" mass="70557" checksum="4FABBEBEDEA27C7C" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHI7</accession>
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        <submittedName>
            <fullName evidence="5">DNA polymerase epsilon subunit C</fullName>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
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                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
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                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
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                <person name="Cuomo C.A."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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    </comment>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:protein heterodimerization activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="HFD_DRAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone, subunit A"/>
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        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
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    </dbReference>
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            <end position="125"/>
        </location>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ45219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="146" mass="16309" checksum="66DF012FCC1E8611" modified="2009-07-28" version="1">MSNLQDLINHDDDEYLPSPSPPQQPEPQHASSSELKTSTTEDLPDSVTQEHILTSFEKIKTHFPAARIKKIMQSDEEIGKVAQATPVIVGRALEIFMANLVEVSLLEAKKQGVKRITASHVKSAIENTEQFDFLVEAVEKYPSLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHN1</accession>
    <name>C4YHN1_CANAW</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CAWG_03579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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        <lineage>
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            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
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                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03579"/>
    <dbReference type="HOGENOM" id="CLU_282842_0_0_1"/>
    <dbReference type="OMA" id="RCCHHTA"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1103" mass="125225" checksum="EDE1F967D09CB916" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHW6</accession>
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            <fullName evidence="6">HIT-type domain-containing protein</fullName>
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        <lineage>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
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                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="component" value="Chromosome 4"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Vps71/ZNHIT1"/>
    </dbReference>
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        <property type="entry name" value="Znf_HIT"/>
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    <dbReference type="PANTHER" id="PTHR13093">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 1"/>
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        <location>
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            <end position="235"/>
        </location>
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        <location>
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        <location>
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            <end position="45"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ45348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="236" mass="26129" checksum="987FF477329CDE3A" modified="2010-10-05" version="1">MLVEEVPKSTNAKTSTIYFSSSINLTARSLGKSTNTGESTSNSNKGRAKVNYNLTQLMNAQTQSNEPTNTGPLKSSQQIQLERLVSKRLVELNQETSTKGFELPKNFVYTSIHSTGGGDNTTKPSHKSRLGNTPATKKILAARRNLNSYFEEERNLISVNTILGINYQFVDFTDIDNNKSATATASTKRRKLESVKPKIRLCCICGDKSNYSRCSSCGLYYCSVKCNNLHQESRCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIG6</accession>
    <name>C4YIG6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_04240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIG6"/>
    <dbReference type="ESTHER" id="canal-q59kl3">
        <property type="family name" value="Duf_676"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YIG6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04240"/>
    <dbReference type="HOGENOM" id="CLU_027968_1_1_1"/>
    <dbReference type="OMA" id="FCTPHVG"/>
    <dbReference type="OrthoDB" id="273452at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000223">
        <property type="entry name" value="Lipase/serine esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF65">
        <property type="entry name" value="ESTERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="3"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ45901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="436" mass="50683" checksum="CE660BF084477D04" modified="2009-07-28" version="1">MSNYHLIILVHGVWGNSSHLAYVEKQIHENIHSYDGTILYTHKTGSHSGYLTYDGIDVNGKRISDEVWEQTKLIEQEKGGKVTKFSVVGYSLGGLISRYCIGYLSSQGYFDNIEPINFTTFCTPHVGVSVPQSHNFSARLYNRIAPLFLADTGSQFFLRDKVGEFGKPLLVWMADPRSKFYKALAKFKYKSLYANVVNDKRCSWYTASISPDDKVNSSYNKRPENINCKYIKGYQPNVIDVTKPFYYEKVDNLRESSNHRFKWFWKTLNWIKLIGTITVYSPIFIITSIVQRIYNRKRVSEFFQNESNDLLHMYEHEHEVGGGEEEEQQQQQQYHSSVFADISNKVDDEQETLVEDIYDAMNWKVSHSSTFPPIRLDHNQSYIVEKLNTIGWKKYPIIIRHTKGTHGAAIIKHYDPNFDEGEVIVRHFVKEVFKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIJ7</accession>
    <name>C4YIJ7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAWG_04273</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIJ7"/>
    <dbReference type="PaxDb" id="5476-C4YIJ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04273"/>
    <dbReference type="HOGENOM" id="CLU_138063_2_0_1"/>
    <dbReference type="OMA" id="QAINMAS"/>
    <dbReference type="OrthoDB" id="3230169at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013963">
        <property type="entry name" value="DASH_Dad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08654">
        <property type="entry name" value="DASH_Dad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="79"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEQ45932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="125" mass="14035" checksum="3C2608C18AA592B8" modified="2009-07-28" version="1">MSKTNTAIYQKIAEKRANLERFREFKELTDDLVLQLESIGDKLETMNGGTASVALILANWKSVVQSISLASLALMKESNDNNKEAFPEPLVRVRVGQSNEENQDDEEADEEEGVRDSEEVEESTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIL7</accession>
    <name>C4YIL7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_04293</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to stimulate activity of mtHSP70 (SSC1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer with PAM16. Component of the PAM complex, at least composed of mtHsp70, MGE1, TIM44, PAM16, PAM17 and PAM18.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIL7"/>
    <dbReference type="SMR" id="C4YIL7"/>
    <dbReference type="PaxDb" id="5476-C4YIL7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04293"/>
    <dbReference type="HOGENOM" id="CLU_017633_13_4_1"/>
    <dbReference type="OMA" id="KLMVMNH"/>
    <dbReference type="OrthoDB" id="240298at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000001">
        <property type="entry name" value="Import inner membrane translocase subunit tim14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763:SF29">
        <property type="entry name" value="MITOCHONDRIAL DNAJ HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="83"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ45952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="143" mass="16381" checksum="B25862DA5BFD998A" modified="2010-10-05" version="1">MVLPIIVGLGATIVALTAKATITAYKQYLHLTPAMIATLNNIKLINLESSMSINKSDPRYAHYKYLRSKYPNRPFLDPMTEQEALLILGIEGNDILNLDKKMIRDRYRKLMILNHPDKNGSQYISQRINEAKDILDKSYMVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIZ2</accession>
    <name>C4YIZ2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">superoxide dismutase</fullName>
            <ecNumber evidence="5">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CAWG_03804</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIZ2"/>
    <dbReference type="SMR" id="C4YIZ2"/>
    <dbReference type="PaxDb" id="5476-C4YIZ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03804"/>
    <dbReference type="HOGENOM" id="CLU_063073_2_0_1"/>
    <dbReference type="OMA" id="TKIACAD"/>
    <dbReference type="OrthoDB" id="159229at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000007">
        <property type="entry name" value="Cell surface Cu-only superoxide dismutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="13" id="KW-0186">Copper</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 20" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944253" description="superoxide dismutase" evidence="20">
        <location>
            <begin position="19"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="21">
        <location>
            <begin position="45"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EEQ45476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="316" mass="35120" checksum="836ECD397F137377" modified="2010-10-05" version="1">MIFIPIIILIYLVSIAASDKSPKIKKNPRNVVAVADFPFGGDTQVKGNVVFSAKEGKHVNVHIDMTGLPKDEGPFFYHIHERSVPGNGNCEAVGLHFNPYNASPVCDEQKNDAYCQVGDLSGKHGCINTTCFELKYSDPYLSLNRKSKSYIIGKSVVFHYPNLTKIACADIEEANELRLQSLIDEYTQTDDAIQLKELNTPLETDYKFDEVEALSSEIYHSDTDPDPPQQELISTEKLYNKTDNVYSPEETRPSDQNKKSHRHSLLPLAKWKKNSPKNYSNISIHGISSDCLNDGMMVTGSVFGSLVLGIAAGIFV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ00</accession>
    <name>GET1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Golgi to ER traffic protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Guided entry of tail-anchored proteins 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">GET1</name>
        <name type="ORF">CAWG_03812</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET2, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Golgi to ER traffic (GET) complex, which is composed of GET1, GET2 and GET3. Within the complex, GET1 and GET2 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the WRB/GET1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ00"/>
    <dbReference type="SMR" id="C4YJ00"/>
    <dbReference type="PaxDb" id="5476-C4YJ00"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03812"/>
    <dbReference type="HOGENOM" id="CLU_089418_2_0_1"/>
    <dbReference type="OMA" id="AEWIISF"/>
    <dbReference type="OrthoDB" id="69461at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000006">
        <property type="entry name" value="Protein GET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03113">
        <property type="entry name" value="Get1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028945">
        <property type="entry name" value="Get1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027538">
        <property type="entry name" value="Get1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650:SF1">
        <property type="entry name" value="GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650">
        <property type="entry name" value="TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04420">
        <property type="entry name" value="CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0931">ER-Golgi transport</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000388582" description="Golgi to ER traffic protein 1">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="32"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03113"/>
        </source>
    </evidence>
    <sequence length="199" mass="22982" checksum="1D97B2BFE5CF461A" modified="2009-07-28" version="1">MLLPDLHPYTILLSIFLVLVVKQLVATIGKSTIQEFVWLVYLKVSSNQSIKTYNSKQHELHETNRQKRAISAQDEYAKWTKLNRQADKLSAELQKLNQEIQQQKSSIDKASNALILVLTTLPIWIARVFYRKTHLFYIRQGIFPKYVEWVLALPFLPNGAVGLTIWMFAVNSVVSNFSFLVSFPFAKRVSKPVRDTKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ56</accession>
    <name>C4YJ56_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_03868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ56"/>
    <dbReference type="PaxDb" id="5476-C4YJ56"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03868"/>
    <dbReference type="HOGENOM" id="CLU_874347_0_0_1"/>
    <dbReference type="OMA" id="TSIFEQM"/>
    <dbReference type="OrthoDB" id="10387805at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ45540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="318" mass="37215" checksum="37BE7934E646347A" modified="2009-07-28" version="1">MTTIKYTLRFVIWLIIYVIPTVSLFNNTRIESAEDSSFLQQIAEFAKWEEQNLYQRPADPPKLSLQSKNSKKTESSNSSFTLPIVKQFFNSSNLVNTSIFEQMSRFRGDKKAPHWTVSTGVFADKSKEWKDEEEECFVPIKEIPQRRPKKYRPRKKYVRPAPPPQPQKWARPNYWSFSSEEDSFSDWWSSDCSESDWSSDDGGKLWFLGMNVAQGEPETKRISIIPSKKLVTRVSEQFYNTYRSSSPNNVMKKRNLDDSDDKYFGFDYEIQPCITNNLSRNHVTFNVLNSRSAKIKMLSRSKLKLLVCFFALHILFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJA8</accession>
    <name>C4YJA8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">General transcription and DNA repair factor IIH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_03921</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the GTF2H2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJA8"/>
    <dbReference type="PaxDb" id="5476-C4YJA8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03921"/>
    <dbReference type="HOGENOM" id="CLU_028556_2_0_1"/>
    <dbReference type="OMA" id="INWVEVP"/>
    <dbReference type="OrthoDB" id="284275at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000477">
        <property type="entry name" value="General transcription and DNA repair factor IIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000015">
        <property type="entry name" value="General transcription factor IIH subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004595">
        <property type="entry name" value="TFIIH_C1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07975">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015919">
        <property type="entry name" value="TFIIH_SSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01047">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VWFA" evidence="14">
        <location>
            <begin position="75"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR015919-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ45593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="472" mass="52629" checksum="E1F31990D9BFD4F9" modified="2009-07-28" version="1">MSARTRSSRRGEVSDLKGANGYAWEDEYQRSWDIVKDDEQGGNSFEAMVQSIIENRKKKIMKNPSTPFQRGIIRTLIIIIDGSSAMSEKDLRPTRLSMTLNYLQEFVVEFFDQNPISRLGIILMRNGVANLVSEVSGSPQYHVDKIRNLKARQHNRFEPKGDPSLQNSLEMARSLLKFNFGSTSNNSKNSKEILVIFGALFTSDPGDIHKTIDNLVKDEIKASVIGLSAQVAICQELVNRTNNEPRNSQSKHYGVIMNESHFKELLMESVTPLPLTESEKQMQESEQNGVPVLRMGFPTKVQPTLTSAIGGSDYIVEFPHLNASFPTQGSEDSKDVVEIQTNKPAAAVATTSSSVIGYQCPQCKCKVCNLPTICPVCGLMLILSTHLARSYHHLVPLAPYKEVKVSPIYDSTYCFGCQLKFPEGVKLGTHKGTLESMTSSRYRCLKCSQDFCINCDVFVHEVLHNCPGCENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJB3</accession>
    <name>C4YJB3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_03926</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJB3"/>
    <dbReference type="PaxDb" id="5476-C4YJB3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03926"/>
    <dbReference type="HOGENOM" id="CLU_046574_1_0_1"/>
    <dbReference type="OMA" id="PCAIMEI"/>
    <dbReference type="OrthoDB" id="93019at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT XANTHINE DIOXYGENASE XAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="135"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ45597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="389" mass="43679" checksum="449FC9A98767BB5D" modified="2009-07-28" version="1">MHKDSLVVTPLADAPFGCSIELPSYCQNDPSLLNDEDFAKLDDAVQRHCVVLIPDQVELSPKSQYNLTKRFDPTIPEPKDTSGGYGHGKEFRHDQSVLKKDGCSVKSQPQVQILGQGTFSPDEPGNENGETINLTHPSHTTFHHTPLTEDQIKNKDQTRFYRWHIDSALYDLSPPKVTTLLGIRIPPTEYQKVVYEDDGSELKLARGATCFFSGAQAFKNLSEEGKEFALNTTVEYAPHPYIFISSAKATWDGLTMVSEGKERDFKDLPEWEESKVKKLPMVWTNPVTKEHHLQVHGCCLYKLHTKKADGSIETLELKEAREKAHKFLRPAIAPEQIYAHAWKQGDLVIFGNRQVTHSVVSELAHLGEAGKRLMHQCNIASGKDPITVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJW4</accession>
    <name>C4YJW4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJW4"/>
    <dbReference type="PaxDb" id="5476-C4YJW4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04135"/>
    <dbReference type="HOGENOM" id="CLU_2236222_0_0_1"/>
    <dbReference type="OMA" id="FQIVYIL"/>
    <dbReference type="OrthoDB" id="10473600at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946708" evidence="2">
        <location>
            <begin position="19"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ45798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="106" mass="11228" checksum="ED249F210C0948D1" modified="2009-07-28" version="1">MRVFQIVYILIISNLIYATSGGGTSSHHHKNDNNIADNTNNNNNNNNNNNNNITNATTTRTVTTSTKTKTHTGGGVAAMGGILGQNGWFYGDAGLMAAIFGAMLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK36</accession>
    <name>C4YK36_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM3</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_05831</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK36"/>
    <dbReference type="PaxDb" id="5476-C4YK36"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05831"/>
    <dbReference type="HOGENOM" id="CLU_000995_6_1_1"/>
    <dbReference type="OMA" id="NVYPQED"/>
    <dbReference type="OrthoDB" id="1882346at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17754">
        <property type="entry name" value="MCM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000008">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000234">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008046">
        <property type="entry name" value="Mcm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056575">
        <property type="entry name" value="WH_MCM3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23191">
        <property type="entry name" value="WHD_MCM3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01659">
        <property type="entry name" value="MCMPROTEIN3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="320"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="689"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="698"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="729"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="757"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="769"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ47265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="878" mass="98498" checksum="ADC347836C31592D" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK39</accession>
    <name>C4YK39_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heat shock protein SSC1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_05834</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK39"/>
    <dbReference type="PaxDb" id="5476-C4YK39"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05834"/>
    <dbReference type="HOGENOM" id="CLU_005965_2_1_1"/>
    <dbReference type="OMA" id="MGTDWKI"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11733">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000003">
        <property type="entry name" value="Heat shock protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000007">
        <property type="entry name" value="Heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003520">
        <property type="entry name" value="PRK05183.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ47268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="648" mass="69674" checksum="FDF0EFFFBFC809E6" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKT3</accession>
    <name>C4YKT3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit OST2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_06091</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DAD/OST2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKT3"/>
    <dbReference type="PaxDb" id="5476-C4YKT3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06091"/>
    <dbReference type="HOGENOM" id="CLU_111220_1_0_1"/>
    <dbReference type="OMA" id="YCCSVGT"/>
    <dbReference type="OrthoDB" id="445566at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003038">
        <property type="entry name" value="DAD/Ost2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02109">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005588">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ47512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="171" mass="18756" checksum="ED41532C3C9D4DE6" modified="2009-07-28" version="1">MAKSASNKKSIPTTSSSSTTTSAASSSVVLKEVKSTLTTTINNYFDTISAQPRLKLIDLFLIFLVLLGILQFIYVLIIGNFPFNSFLGGFISCVGQFVLLVSLRLQINDSTTTTTDKESDDQLELDEDKIENGTTGGGNGRLFKEITPERSFGDFIFASLILHFIVIHFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKU9</accession>
    <name>C4YKU9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_06108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKU9"/>
    <dbReference type="PaxDb" id="5476-C4YKU9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06108"/>
    <dbReference type="HOGENOM" id="CLU_624948_0_0_1"/>
    <dbReference type="OMA" id="FITEQRI"/>
    <dbReference type="OrthoDB" id="4022940at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="512" mass="57179" checksum="A5D91B33CD773F6E" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKY6</accession>
    <name>C4YKY6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="4 14">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_06145</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the sequential decarboxylation of four acetate groups of uroporphyrinogen-III (octacarboxyporphyrin) to yield coproporphyrinogen-III (tetracarboxyporphyrin) with the formation of intermediate hepta-, hexa- and penta-carboxylate porphyrinogens in the heme biosynthesis pathway. Acts on a number of porphyrinogens, but only coproporphyrinogen III can ultimately be converted to heme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>uroporphyrinogen I + 4 H(+) = coproporphyrinogen I + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:31239"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62626"/>
            <dbReference type="ChEBI" id="CHEBI:62631"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="4 14"/>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKY6"/>
    <dbReference type="PaxDb" id="5476-C4YKY6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06145"/>
    <dbReference type="HOGENOM" id="CLU_040933_0_0_1"/>
    <dbReference type="OMA" id="LWLMRQA"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000004">
        <property type="entry name" value="Uroporphyrinogen decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="16">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="17">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ47565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="361" mass="40672" checksum="0C7D21BEC5E39940" modified="2009-07-28" version="1">MPEFPPLKNDLILRAAKGEKVERPPIWIMRQAGRYLPEYHKVKGNRDFFETCQDAEIASEITIQPVDHFDGLIDAAIIFSDILVIPQAMGFEINMVEGKGPVFAAPLRTPDDLSRIDLKPDVKTKLAWAYKAITLTRTKLNGRVPLLGFVGAPWTLLVYMTEGQGSKMFRFAKEWIFKYPEAAHKLLQATCDACVEFLAQQVVAGAQMVQIFESWAGELGPDDFNEFSLPYLKQIAAKLPPRLKELGVEEYIPMTVFAKGAWYALDDLCDSGYDCVSLDWLYDPKNAVKVVNGRRITLQGNLDPGVMYGSDKVIAKKVKTMLEGFGKQNYIINFGHGTHPFMDPKKIEFFLQQCHKVGESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL26</accession>
    <name>C4YL26_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_01540</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL26"/>
    <dbReference type="SMR" id="C4YL26"/>
    <dbReference type="PaxDb" id="5476-C4YL26"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01540"/>
    <dbReference type="HOGENOM" id="CLU_015166_16_0_1"/>
    <dbReference type="OMA" id="NWAVGIP"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015227">
        <property type="term" value="F:O-acyl-L-carnitine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902603">
        <property type="term" value="P:carnitine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF4">
        <property type="entry name" value="CONGESTED-LIKE TRACHEA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="9"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="103"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="196"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ43307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="284" mass="30069" checksum="2862861FA39D66FF" modified="2010-10-05" version="1">MDDVDSALADNVKSFAAGGFGGICAVLTGHPFDLVKVRLQTGLYNSSVQCVKQTIAKDGLTGLYRGVLPPLLGVTPMFAVSFWGYDVGKRLVSTYTGKSIDQFEIKEISTAGFISAIPTTLVAAPFERVKVMMQIQEGNKSKSMAGVVAEMYKTGGLRSIFKGSVATLARDGPGSALYFATYEYLKKELSSPGEDLSLFAIMTAGGFAGVSMWLGVFPIDTIKSTQQSSNVPISILQTTKNIYAKGGIKAFFPGVGPALARSFPANAATFLGVELARKALDSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL90</accession>
    <name>C4YL90_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinetochore protein NDC80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_01607</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
            <location evidence="11">Centromere</location>
            <location evidence="11">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the NDC80/HEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL90"/>
    <dbReference type="PaxDb" id="5476-C4YL90"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01607"/>
    <dbReference type="HOGENOM" id="CLU_012583_1_0_1"/>
    <dbReference type="OMA" id="PSHKFQK"/>
    <dbReference type="OrthoDB" id="7459479at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.30:FF:000001">
        <property type="entry name" value="Probable kinetochore protein ndc80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="entry name" value="Ncd80 complex, Ncd80 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055260">
        <property type="entry name" value="Ndc80_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 11" id="KW-0137">Centromere</keyword>
    <keyword evidence="3 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Ndc80 CH" evidence="14">
        <location>
            <begin position="180"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="67"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="155"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="377"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="440"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="641"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="155"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ43371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="783" mass="91819" checksum="E1989D651258689A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLB0</accession>
    <name>C4YLB0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Autophagy-related protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_01627</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ATG13 family. Fungi subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLB0"/>
    <dbReference type="PaxDb" id="5476-C4YLB0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01627"/>
    <dbReference type="HOGENOM" id="CLU_366802_0_0_1"/>
    <dbReference type="OMA" id="FHQVGPT"/>
    <dbReference type="OrthoDB" id="70161at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.900.10:FF:000025">
        <property type="entry name" value="Autophagy-related protein 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040182">
        <property type="entry name" value="ATG13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018731">
        <property type="entry name" value="Atg13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10033">
        <property type="entry name" value="ATG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 13 N-terminal" evidence="6">
        <location>
            <begin position="38"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="277"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="398"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="541"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="692"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="429"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="445"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="566"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="600"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="614"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="695"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="710"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="721"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ43391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="761" mass="84397" checksum="D2B77F236F8C66B5" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLJ4</accession>
    <name>C4YLJ4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein N-terminal and lysine N-methyltransferase EFM7</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM7</name>
        <name evidence="6" type="ORF">CAWG_01712</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLJ4"/>
    <dbReference type="SMR" id="C4YLJ4"/>
    <dbReference type="PaxDb" id="5476-C4YLJ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01712"/>
    <dbReference type="HOGENOM" id="CLU_032409_0_0_1"/>
    <dbReference type="OMA" id="VGHNPLW"/>
    <dbReference type="OrthoDB" id="46564at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03223">
        <property type="entry name" value="Methyltr_EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025784">
        <property type="entry name" value="EFM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF10">
        <property type="entry name" value="PROTEIN N-TERMINAL AND LYSINE N-METHYLTRANSFERASE EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51560">
        <property type="entry name" value="SAM_MT_NNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ43475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="262" mass="30430" checksum="4C1EAFD9320AD296" modified="2009-07-28" version="1">MSEDEISIEGDLFEEPEGFLPERPSSHFSTYKRKIPNAEPQEITMKLVGHNPLYGHLLWNAGIYTADYLDKHSDTLVQGKKILELGAASALPSLVCSLNHAKEVIVTDYPDPDLLSHMEYSFNDLKEKTKYELSPWKVKGYIWGHDLGELLFDEPGRKLAEEEKFDLIILSDLVFNHSEHHKLLDTCRQSLKRNGGKCLVVFSPHRPYLLQDDLSFFETAKQYQFKTEKIEMVTWKPMFEEDEETADIRARVYAFFLIPEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLY5</accession>
    <name>C4YLY5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLY5"/>
    <dbReference type="PaxDb" id="5476-C4YLY5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01857"/>
    <dbReference type="HOGENOM" id="CLU_2305670_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="100" mass="11695" checksum="4E2CB9F11F9ACCF2" modified="2009-07-28" version="1">MLRFRVVVWKLQNVVFIAIPKTLHPATAITTRIHHPRGIPSNNKPKKQEQRNTTSSYRAHAPLLLLFLFSLFLSTCLCFLFTNSFTYHIPFWNPCQKVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMB0</accession>
    <name>C4YMB0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kinetochore protein Sos7 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_01989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMB0"/>
    <dbReference type="PaxDb" id="5476-C4YMB0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01989"/>
    <dbReference type="HOGENOM" id="CLU_778446_0_0_1"/>
    <dbReference type="OMA" id="NQTIMEY"/>
    <dbReference type="OrthoDB" id="18959at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037475">
        <property type="entry name" value="Sos7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048781">
        <property type="entry name" value="Sos7_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329:SF1">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20882">
        <property type="entry name" value="Sos7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Sos7 coiled-coil" evidence="2">
        <location>
            <begin position="55"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ43741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="374" mass="44115" checksum="025D0203A07C3993" modified="2010-10-05" version="1">MSENTSQELKDELSSIQKNSINYSILTSDQDFHNANIKLNNPKLIKDELLHYQNIFSKLKFLYLEQETRDIFLREISEINYKLPPKESNFINEIEFESFNQETQISKQRLKKNKQKMYNKISQLELITNDTDLLYTNYSNRSRQIQQLLNDEINSLELKINDELMMQNDNQTIMEYMMDSRPSSSVSEMISLSQNNENHNHNHNNQDQVNDNDILKKNAIDKLHEINNDINEITKQYENNLYQIEIITKKLNDLNDILKNLKPREYKDDKLQKYTKWSIEMNEILTKLSIINKVELNKEEGTTSGNEYRLSISYGDSGTNNLIIKYHEGDWKIVSLQGYKDNNNNNKLISKINSLGNQNDFFKAIAQFIVELTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMD8</accession>
    <name>C4YMD8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_02017</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMD8"/>
    <dbReference type="PaxDb" id="5476-C4YMD8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02017"/>
    <dbReference type="HOGENOM" id="CLU_008201_1_0_1"/>
    <dbReference type="OMA" id="RKTWIYE"/>
    <dbReference type="OrthoDB" id="2155291at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04436">
        <property type="entry name" value="DEP_fRgd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04399">
        <property type="entry name" value="RhoGAP_fRGD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000169">
        <property type="entry name" value="Rgd3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF17">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN RGD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="5">
        <location>
            <begin position="1"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="3">
        <location>
            <begin position="220"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="467"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="681"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="683"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="730"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="759"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="789"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="821"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="867"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ43769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="879" mass="100402" checksum="2ADF090A5CB25B54" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMG8</accession>
    <name>C4YMG8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GTP-binding protein YPT31/YPT8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_02048</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMG8"/>
    <dbReference type="PaxDb" id="5476-C4YMG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02048"/>
    <dbReference type="HOGENOM" id="CLU_041217_23_2_1"/>
    <dbReference type="OMA" id="ITAIYQM"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000067">
        <property type="entry name" value="ras-related protein RABA1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="188"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ43799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="219" mass="24563" checksum="DDAEF4ECD8C89784" modified="2009-07-28" version="1">MADNSDDYSYDYEYLYKIVLIGDSGVGKSNLLSRFTRDEFNLESRSTIGVEFATRTLEIDGKRVKAQIWDTAGQERYRAITSAYYRGAVGALIVYDIAKTESYESVSRWLKELKEHADANIIIELVGNKSDLDHLRAVPTEEAKNFAMENNLLFTEASALSSDNVDLSFHQLLKNIYEMISKHQLENNDSKQTNTAGGPTISLTPAPQEKKNKNNGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMN3</accession>
    <name>C4YMN3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U6 snRNA phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMN3"/>
    <dbReference type="PaxDb" id="5476-C4YMN3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02116"/>
    <dbReference type="HOGENOM" id="CLU_963102_0_0_1"/>
    <dbReference type="OMA" id="ETIYSHR"/>
    <dbReference type="OrthoDB" id="4025120at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="34091" checksum="5466F168CA754B52" modified="2009-07-28" version="1">MDLIQHYTSETESETETQEEGDRDFPIESDEKEGENKLESQTSIPPPLPNIEIYSQLYQQNMSKTVATTFGYLPWKPPFAAIRNIERACLRTISKIPLLSENYKFVSTHKDTSRLVKQHLTVFPGVALNTPDTHLVADKIFESVAKLEVPKSMIVTVGGGSDPLSSILNKPRKAIRFQTVNYLELARGFTNDRLFLLIYVKHTADSRKYADELTKLCRQTLEDNGYLQNPERYSPSSYHVSICTGYLKKAELSNKDIAKVNKQLRSITIPELVDLSFDVEELCCTGSSETIYSHRLLPYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMQ7</accession>
    <name>C4YMQ7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUMO-conjugating enzyme UBC9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme E2-18 kDa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_02141</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMQ7"/>
    <dbReference type="PaxDb" id="5476-C4YMQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02141"/>
    <dbReference type="HOGENOM" id="CLU_030988_12_0_1"/>
    <dbReference type="OMA" id="TWECGIP"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000035">
        <property type="entry name" value="SUMO-conjugating enzyme ubc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="13">
        <location>
            <begin position="3"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ43888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="158" mass="18265" checksum="1863A776482EDCB0" modified="2009-07-28" version="1">MSLCLIRLQEERKQWRKTHPFGFFAKPNKASDGSLDLKHWTAGIPGKEGTIWEGAVYPVTLEFPDEYPSKPPKVKFRPKFYHPNVYPSGTVCLSILNESQDWKPAITLTQILLGVQELLDTPNKESPAQEDAYRHFVHDMNTYVKRVKAEVKKYMTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMZ2</accession>
    <name>C4YMZ2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation machinery-associated protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="HOGENOM" id="CLU_184661_2_0_1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
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            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="64" mass="6655" checksum="0A164B632F8D7C53" modified="2009-07-28" version="1">MSGRQGGKAKPLKAPKKKQQDFDEDDAAFKAKQKADAAAKKAMAEKAKKGGPLVGGGIKKSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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                <person name="Staggs R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome R"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="678" mass="79195" checksum="F10883C80E5186EB" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN17</accession>
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            <taxon>Candida/Lodderomyces clade</taxon>
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    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
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                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
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                <person name="Skrzypek M.S."/>
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                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
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                <person name="Berman J."/>
                <person name="Berriman M."/>
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                <person name="Lorenz M.C."/>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="SMR" id="C4YN17"/>
    <dbReference type="PaxDb" id="5476-C4YN17"/>
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        <property type="component" value="Chromosome R"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0015171">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF17">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="454"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="502"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="11">
        <location>
            <begin position="69"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ43998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="571" mass="62707" checksum="C959FE610B12F2B7" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN80</accession>
    <name>C4YN80_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PIH1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_02320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN80"/>
    <dbReference type="SMR" id="C4YN80"/>
    <dbReference type="PaxDb" id="5476-C4YN80"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02320"/>
    <dbReference type="HOGENOM" id="CLU_072113_0_0_1"/>
    <dbReference type="OMA" id="EWCLESC"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050734">
        <property type="entry name" value="PIH1/Kintoun_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041441">
        <property type="entry name" value="Pih1_CS_Ascomycota"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012981">
        <property type="entry name" value="PIH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997:SF0">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08190">
        <property type="entry name" value="PIH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18482">
        <property type="entry name" value="Pih1_fungal_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIH1 N-terminal" evidence="2">
        <location>
            <begin position="14"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Pih1 Ascomycota CS" evidence="3">
        <location>
            <begin position="231"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ44061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="35507" checksum="6942FC17EB8C278D" modified="2010-10-05" version="1">MIHESSLVMSLVEEQESITLHPKPGFVIKTKILESKDLSRTLTKVFINVCHSPDVPKPDVDFEPEIVFPLIIDNEWEIPIILSKEKKSKDKKGFPSFVYDCCINSECFQWCQISTDLKSILIEWCIESVELVYSLTLEREYSMPKMLAKGELSNTVVTKKELLGSGLKDRLKELQQNETLGLIKEMESEEEEELPDLMNINKTPAKPLIEEINYQLKPSPKSKPPKPVKELTYTVSFKNVADPNFNLAVIVTYDEEIDNNFSITYSSESSSLLVKSSGLKFASGNSLEIPVSPDIIVTNTKCFAVHNTMYIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNI7</accession>
    <name>C4YNI7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_01449</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNI7"/>
    <dbReference type="PaxDb" id="5476-C4YNI7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01449"/>
    <dbReference type="HOGENOM" id="CLU_1740258_0_0_1"/>
    <dbReference type="OMA" id="CAFSITT"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="132" mass="14204" checksum="6DE4645E9F532C49" modified="2009-07-28" version="1" fragment="single">MSSGDSDSNSITSLKDIDGADTNSLNQPVSRVRTTGDGDEFVIIGNKKYYRHELMQAFGGTFDVGLHPPPKLKIGNPSPLGLCAFSITTLIMSLYGLNVKDIHNSNVVVGMAIFYAGTMQTLAGVWEFFVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNU2</accession>
    <name>C4YNU2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_02875</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNU2"/>
    <dbReference type="PaxDb" id="5476-C4YNU2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02875"/>
    <dbReference type="HOGENOM" id="CLU_019279_1_0_1"/>
    <dbReference type="OMA" id="DWMHLNG"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000968">
        <property type="entry name" value="Casein kinase I, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="44"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="339"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="437"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ44601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="497" mass="56660" checksum="011C4EED2FE86CA0" modified="2009-07-28" version="1">MTTNPALAAAQASHNNIPTKQMNHSTSSSNGNGSNNSSVVGLHYKIGKKIGEGSFGVIFEGTNIINGVPVAIKFEPRKTEAPQLRDEYRTYKHLQGCDGIPNAYYFGQEGLHNILVIDLLGPSLEDLFDWCGRRFSVKTVVQVAIQMLTLVEEVHRHDLIYRDIKPDNFLIGRRGATDENNVHLIDFGMAKQYRDPRTKQHIPYREKKSLSGTARYMSINTHLGREQSRRDDLEALGHVFFYFLRGQLPWQGLKAPTNKQKYEKIGDKKRTTPAVTLCDGLPQQFAEYLDSVRSLPFDAEPPYEEYRMLLLSVLDDLGQACDGDMDWMHLNGGRGWDATINKKPNLHGYGHPNPPNERERRHRDQRRTRQHQQSQQVQQQQLQAQAQAQQLQQAQQLQQAQQAQQQQSQQHQPLSAAQLHQQKLQHLVNRPLPPIKQESQSAIQSGNGHHELLNNNLGDQHGGKHEGYSSRPDQYQQQQMVAEEEENKGFWSKLCCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNW5</accession>
    <name>C4YNW5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA wybutosine-synthesizing protein 2</fullName>
            <shortName evidence="6">tRNA-yW-synthesizing protein 2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_02898</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36355"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.5.1.114"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNW5"/>
    <dbReference type="PaxDb" id="5476-C4YNW5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02898"/>
    <dbReference type="HOGENOM" id="CLU_023588_1_0_1"/>
    <dbReference type="OMA" id="FELNPWS"/>
    <dbReference type="OrthoDB" id="2387925at2759"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102522">
        <property type="term" value="F:tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026274">
        <property type="entry name" value="tRNA_wybutosine_synth_prot_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF25">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038972">
        <property type="entry name" value="Trm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="7">
        <location>
            <begin position="145"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR038972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ44624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="419" mass="48493" checksum="E0F8B9701D2648EE" modified="2009-07-28" version="1">MAIKLLIDNPKQVKPIKSYLEDHNWLNKSFKIQKKNDIFHIFTNLNEIPSQLSQYNHETYEQEDDGDLNTKNKTTTLTLASIITDYCHANNIENIEIPKRWSIYPPMILFNSTGSTSESNGHPTSDTIFNPQHQKLWENVLSNQKSIFGTSEITHIALNKPIIESDIMRRPHNLIPIIGDFGPDISIDNKPPSPTESDFNRAFWCHVIQNGIYQTWAPKYTMFSRGNIKEKKRVLDWFKNLDQTIVFDFYCGIGYFSLSYLKNGGKLLCWELNPWSIEGFRRSLEKMKINYKIYTSGDKFSINDLNQFDACLFLESNEQITTRVIDQVKDNSLPISHINLGLLPSSKQSWTLANNLINKSTINTNVHIHENVHIDDFEKIKTDVKKVFTNGKVLHLEKVKTFAPDIWHIVIDIENIKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNZ4</accession>
    <name>C4YNZ4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Bis(5'-adenosyl)-triphosphatase</fullName>
            <ecNumber evidence="2 11">3.6.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_02928</name>
        <name evidence="14" type="ORF">CAWG_02946</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Cleaves A-5'-PPP-5'A to yield AMP and ADP. Can cleave all dinucleoside polyphosphates, provided the phosphate chain contains at least 3 phosphates and that 1 of the 2 bases composing the nucleotide is a purine. Is most effective on dinucleoside triphosphates. Negatively regulates intracellular dinucleoside polyphosphate levels, which elevate following heat shock.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 11">
            <text>P(1),P(3)-bis(5'-adenosyl) triphosphate + H2O = AMP + ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13893"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.1.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.6.1.29" evidence="2 11"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNZ4"/>
    <dbReference type="SMR" id="C4YNZ4"/>
    <dbReference type="PaxDb" id="5476-C4YNZ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02928"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02946"/>
    <dbReference type="HOGENOM" id="CLU_056776_7_2_1"/>
    <dbReference type="OMA" id="DAIYGMM"/>
    <dbReference type="OrthoDB" id="680339at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047710">
        <property type="term" value="F:bis(5'-adenosyl)-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000011">
        <property type="entry name" value="Fragile histidine triad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051884">
        <property type="entry name" value="Bis(5'-adenosyl)-TPase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243:SF1">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="12">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="10">
        <location>
            <begin position="97"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="8">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="92"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ44653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ44670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="180" mass="21103" checksum="8C2EA6AA9702FF6B" modified="2010-10-05" version="1">MTSQEIYFYRFLVSKQVFYKSRYTYALVNLKPLVPGHVLVVPLRTNVLRFGDLSPEESVDYMHTLQLIHKFIQKVYKADSLNLAIQDGPESGQSVPHLHTHIIPRHKGDGYGDSIHTMLESKDLEREYQEFFQRKSQYQIDQMTKKNEFSKGDEERVARSESVMSEEAVWLARELEKFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP94</accession>
    <name>C4YP94_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_03043</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YP94"/>
    <dbReference type="PaxDb" id="5476-C4YP94"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03043"/>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="OMA" id="IHWPASI"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004032">
        <property type="term" value="F:aldose reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019568">
        <property type="term" value="P:arabinose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042843">
        <property type="term" value="P:D-xylose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042180">
        <property type="term" value="P:ketone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000018">
        <property type="entry name" value="Glycerol dehydrogenase Gcy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="7">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ44753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="295" mass="33059" checksum="339AA160EDEEE890" modified="2009-07-28" version="1">MPAQLQVNTDYFTLNNGNKIPAVGLGTWQATNEDEAYRAVLAALKNGYKHIDTAAIYGNEEQVGKAIKDSGVPREELFVTTKLWNADHKNIEEALETSLKKLGLDYVDLYLIHWPASIDKSTNKPYTDFDYVDTYRGLQKVYKNSKKIRAIGVSNFTKKKLERLLSSEGVDVVPAVNQIEAHPLLTQPELYDYLKEKGIVLEAYSPLGSTNSPLFKNETIVKIAEKNGVEPAQVLVSWAIQRKTVVLPKSVTESRVISNLKTFTLPSEDFETLNKLSEKDGVVRTCNPAFNNFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPL2</accession>
    <name>C4YPL2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_02413</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPL2"/>
    <dbReference type="MEROPS" id="T01.971"/>
    <dbReference type="PaxDb" id="5476-C4YPL2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02413"/>
    <dbReference type="HOGENOM" id="CLU_035750_4_1_1"/>
    <dbReference type="OMA" id="YGYDMPV"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000026">
        <property type="entry name" value="Proteasome subunit alpha type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ44151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="247" mass="27451" checksum="9DA639DE096B2535" modified="2010-10-05" version="1">MSNSAGFDRHITIFSPEGRLYQVEYAFKAINSANITSLGITGQDSAVIISQKKIPDKLLDPKTVSYIFKITPSIGMVATGSIADARAQAMRARSEATEFRYKYGYEMPVESLSRRMANISQLYTQRAYMRPLGVALTFIQVDFADEGRGPQIFKCDPAGYFTGVKAVATGPKQQEATTYLEKKFKKTDAVKGDWQKTVEFAIIALSSVIGTEFRKNDIEIGVATEGEFRILTPEEIDERLISIAEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPV6</accession>
    <name>C4YPV6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_02510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPV6"/>
    <dbReference type="PaxDb" id="5476-C4YPV6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02510"/>
    <dbReference type="HOGENOM" id="CLU_003233_0_0_1"/>
    <dbReference type="OMA" id="NLVDHWL"/>
    <dbReference type="OrthoDB" id="2801544at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF51">
        <property type="entry name" value="SNF2-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="1067"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="972"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1007"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ44245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1250" mass="144373" checksum="F2D32833AF083206" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPX3</accession>
    <name>C4YPX3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ran GTPase-activating protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_02527</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPX3"/>
    <dbReference type="PaxDb" id="5476-C4YPX3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02527"/>
    <dbReference type="HOGENOM" id="CLU_028747_3_0_1"/>
    <dbReference type="OMA" id="NGSMEAW"/>
    <dbReference type="OrthoDB" id="184583at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="356"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="356"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ44262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="45994" checksum="7EF82121523E3BD3" modified="2010-10-05" version="1">MASVEVELGVTPETTYSISGKQLKFDSESDIAPYIKELTEKENVKKVDFSGNTIGIEASKALSEALLKHKDTIVEINFSDLYTGRLNTEIPQSLEYLLPALLKLPNLKLINLSDNAFGLQTIDPIEAYLAKAVSIEHLILSNNGMGPFAGSRIGGSLFKLAKAKKAEGKESLKTFICGRNRLENGSVNYLSVGLRNHKDLEVVRLYQNGIRPAGISKLVEQGLSNNKKLKVLDLQDNTITTRGAIHIAESLSNWPLLVELNLNDSLLKNKGSLKLVEAFHAGDEKPQLITLKLQYNELETDSLRVLADAIASKLPQLKFLELNGNRFEEDSEHIDKINGIFEERGYGEIDELDELEELDSEEEEDDEDDEGEDDTLEEDLDLTQLEEELAGVSLEDKDGNVDEIAEELSKTHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ07</accession>
    <name>C4YQ07_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arylsulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_02561</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ07"/>
    <dbReference type="PaxDb" id="5476-C4YQ07"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02561"/>
    <dbReference type="HOGENOM" id="CLU_006332_11_1_1"/>
    <dbReference type="OMA" id="YSDQWAQ"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019637">
        <property type="term" value="P:organophosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16025">
        <property type="entry name" value="PAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000044">
        <property type="entry name" value="Arylsulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF33">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="11"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ44296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="586" mass="65817" checksum="33E074BDC23B882E" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQA6</accession>
    <name>C4YQA6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQA6"/>
    <dbReference type="SMR" id="C4YQA6"/>
    <dbReference type="PaxDb" id="5476-C4YQA6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02662"/>
    <dbReference type="HOGENOM" id="CLU_010412_6_4_1"/>
    <dbReference type="OMA" id="YAGKQMA"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000284">
        <property type="entry name" value="Ubiquitin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="77" mass="8545" checksum="4EFCFF73B930F18A" modified="2009-07-28" version="1">MQIKVKTLTGRDMPLDVEPQDKIIRIKEMMEEKEGISPAQQRLIFNGSQLNDDQTVQEAGIQAGASLHLVLTLRGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQC0</accession>
    <name>C4YQC0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQC0"/>
    <dbReference type="SMR" id="C4YQC0"/>
    <dbReference type="PaxDb" id="5476-C4YQC0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02677"/>
    <dbReference type="HOGENOM" id="CLU_089352_0_0_1"/>
    <dbReference type="OMA" id="HINNVEM"/>
    <dbReference type="OrthoDB" id="4080914at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="102"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="204" mass="23519" checksum="5283ACEF748CEACB" modified="2010-10-05" version="1">MDNSYDDLSAISTLVSSLSQNVSDSEEYITKLQSLSKNLVSKDQYEQLSKEADVLTESNNNANDNDEMSIIRKLEEERLSLIMDIQREDFVSSKLIELIDQNQEIIESVKEYLEARESIQEEEAAYTKKQLDIFVNDIVLPILAQLNENLTGLSARMKNVARKLLRIQLRAKENPDLAMSENYRKEFTELVQCFCSLCKEYKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQC4</accession>
    <name>C4YQC4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Allantoate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_02681</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQC4"/>
    <dbReference type="PaxDb" id="5476-C4YQC4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02681"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OMA" id="CMFPLMC"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000245">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF1">
        <property type="entry name" value="ALLANTOATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ44413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="58787" checksum="FDD1C070BFCF8C36" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQJ3</accession>
    <name>C4YQJ3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_02751</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Vacuole membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQJ3"/>
    <dbReference type="SMR" id="C4YQJ3"/>
    <dbReference type="PaxDb" id="5476-C4YQJ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02751"/>
    <dbReference type="HOGENOM" id="CLU_085752_1_1_1"/>
    <dbReference type="OMA" id="MGVMKPD"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="15"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="91"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ44482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="160" mass="16222" checksum="14E52BBA7332B964" modified="2009-07-28" version="1">MSDLCPVYAPFFGSIGCAAAIVFTCFGASYGTAKSGVGICATSVTRPDLLVKNVVPVVMAGIIAIYGLVVSVLVSDSLSQKQALYTGFIQLGAGLSVGLSGLAAGFAIGIVGDAGVRGTAQQPRLFVGMILILIFAEVLGLYGLIVALLLNSRASQDVTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQM8</accession>
    <name>C4YQM8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA topoisomerase</fullName>
            <ecNumber evidence="6">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_02787</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="6"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQM8"/>
    <dbReference type="PaxDb" id="5476-C4YQM8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02787"/>
    <dbReference type="HOGENOM" id="CLU_002929_1_1_1"/>
    <dbReference type="OMA" id="VIHNVYS"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035825">
        <property type="term" value="P:homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.140:FF:000003">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="7">
        <location>
            <begin position="2"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="8">
        <location>
            <begin position="166"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ44517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="629" mass="71871" checksum="3B615841EAD4437A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR56</accession>
    <name>C4YR56_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein bL31m N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR56"/>
    <dbReference type="PaxDb" id="5476-C4YR56"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04555"/>
    <dbReference type="HOGENOM" id="CLU_130029_0_0_1"/>
    <dbReference type="OMA" id="RRSQFPK"/>
    <dbReference type="OrthoDB" id="5587740at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034600">
        <property type="entry name" value="Ribosomal_bL31m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048874">
        <property type="entry name" value="Ribosomal_bL31m_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL31M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21492">
        <property type="entry name" value="bL31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein bL31m N-terminal" evidence="2">
        <location>
            <begin position="42"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="209" mass="23620" checksum="DCBA11C12A90E3E4" modified="2009-07-28" version="1">MLTRRIISLKPFPVSISTRSKATSASPTSNSTSPYGDVNLSNRRVMKRIVQGKARPAIFYQFETLVEMSDGSVIKRYSQAPKDEIRMINDQRNNLMWNPNNNDLRNGGIGGLGGDLQAKGKVNKFKQKFANSFEEEEEVGKQSKEGKEGKEEKKVEGEGEVDEEAIRRKQLELQKARDEELFELMGENAEEVVGGGKLYDKKADKKRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR98</accession>
    <name>C4YR98_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_04597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR98"/>
    <dbReference type="PaxDb" id="5476-C4YR98"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04597"/>
    <dbReference type="HOGENOM" id="CLU_1230985_0_0_1"/>
    <dbReference type="OrthoDB" id="4092442at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37449">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37449:SF1">
        <property type="entry name" value="OS02G0159950 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="192" mass="20118" checksum="A024AD67CAD4BE28" modified="2010-10-05" version="1">MYKVLSSLPGLSIAGSIISGLLVAPMTNTPFLSFKPSNSVNKVLTTLELDSDIDVSLLGTNASNSSKKIIHGVEARALWKTCRTAFSDSPTYLFNNSGPFIEIKFARDSLATALANSVLPQPGGPHIKTPAGAAIPTFKYNSGFLIGCTIHICNSISILNKAPTFCHVTSGIVANPSLLASGWTSGSAFTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRD5</accession>
    <name>C4YRD5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_04634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRD5"/>
    <dbReference type="PaxDb" id="5476-C4YRD5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04634"/>
    <dbReference type="HOGENOM" id="CLU_070142_0_0_1"/>
    <dbReference type="OMA" id="SDEAFMY"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521:SF0">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="303" mass="35862" checksum="0813087F30A551F9" modified="2009-07-28" version="1">MSIKIDHILKSSKELYPRIIEELSSQFTKKYDKNTKTFTQLNTWKEDELTNTLLKRYQETETTWITKDELINLLDWKLAKGKFRPMLPKLIKSNDSIDVEEITKQGYQYLLDYFKLHTSNDKQKQQPKLLDKFWGEANDQDKIEYSEVIKKSFEKFTLLKGVGPAMASLLANLLIKINPYLTPPFFSDESFSFYYMESFRPGEKIKYNMKEYIEELLPVYLEIISQYPDVTMNTLERGGWALKTYQIQRNEKLANIEIEYITTTTTTTDNDDNEEEDINRLKLDHKPDLKLVASAPRRKKQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRE9</accession>
    <name>C4YRE9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRE9"/>
    <dbReference type="PaxDb" id="5476-C4YRE9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04648"/>
    <dbReference type="HOGENOM" id="CLU_910745_0_0_1"/>
    <dbReference type="OMA" id="SVMENDI"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060962">
        <property type="term" value="P:regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018837">
        <property type="entry name" value="TF_CRF1/IFH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28057">
        <property type="entry name" value="PROTEIN IFH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28057:SF1">
        <property type="entry name" value="PROTEIN IFH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="306" mass="34474" checksum="7B39A52CAB633A03" modified="2009-07-28" version="1" fragment="single">MGYKNSDNTNNKFSRKSMSPSFTGGKGRKTVGKKVKKTIPRKTVNWSSYDVNSDSNEDSDEESENENENENDSDNDDEVDDETEHHHLDGLYSLMGKRPHDSSSNGDDDDDDDDDNNNKNIFSSTSSDGDSDEAMFSSSDDDSDVDFVKLQAQQKAHALKIAKARKGLKSKPKNESNDDAIASSSESESNSESDNEEDDDDVVSLKKLKPRKKSFLKYGRRRSDAVLPDINFKFEFDTGENDELEAGNQETHIKEPEEEDIGEEVDYSPENPVDSNNVPSLEFEFDHHLIEVPKINEEELNSDEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRF6</accession>
    <name>C4YRF6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_04655</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:Golgi to vacuole transport"/>
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    </dbReference>
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            <end position="275"/>
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    </evidence>
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        <source>
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        </source>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="276" mass="31994" checksum="DFB623F5B3A72CB2" modified="2009-07-28" version="1">MSFNTPFSEDLERTATNDSHRYKDYPEFDSLSTSIEKQLHYINSELLSSIRSDLAKFEKDKTDTSLSESLSGQFRKTTDAFKKVNKFVKSLNASIVTTEREHEDVETINYLKQKEAIQIKLIRDSLANFNNFQKRFELCQTTQLPEDGTNLSETEPGSIQQSQQQVQITYEPINAEELEQQTLLIQEREREIHQIQQDTQEINDIFSNLSSIVNEQQFQIDSIENNIFSYSSNAREASNELRRAERYQKRSSGRLLCCFMILVAIASFIILIGLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
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    <name>C4YRI5_CANAW</name>
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        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">CAWG_04685</name>
    </gene>
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        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="MIDMTIR"/>
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    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="507"/>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="530" mass="59649" checksum="650EC9085C102342" modified="2009-07-28" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS23</accession>
    <name>C4YS23_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_04881</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
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            <dbReference type="PubMed" id="19465905"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OMA" id="YWGDYTI"/>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19177">
        <property type="entry name" value="SET_SETD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016852">
        <property type="entry name" value="SET_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044429">
        <property type="entry name" value="SETD4_SET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF47">
        <property type="entry name" value="ACTIN-HISTIDINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="33"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ46526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="433" mass="50312" checksum="8CBA2E110CC45D53" modified="2009-07-28" version="1">MIDNFDLKLETLLHWVKNKDDEKKISNHTYISPKIDVKDVRSSGRGIYAVEPLKKGELILNIPHSFLLNFTTVMAHIAKYNGMAIDSHIHVPFDKSEDEYTEIYRTLTKEEILELSSFQLLSLYLTFERKRSHKSFWKPFLDMLPSMDDFELMPIDWPQEVCTLLPSSTEVRNKKVRSRFDNDYQVICELIKTKIDKDGDVTTFLPRQEVLLSWLCINSRCLYMDLPTSKNSADNFTMAPYVDFMNHSCDDHCTLKIDGKGFQVRTTSQYNTGDQVYLSYGPHSNDFLLCEYGFVIPDNKWNDLDISQYIIPLLKPPHVEFLKSFDYYDNYTMTKEGISFRTEVALATLQESDPQNSRKLLALINGYTDGDVFKEHSNALLSVILNKIIHEAEKHQHLQYNDDKRKKAIGTLYHDMKSIASNVLTYIQDETSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS31</accession>
    <name>C4YS31_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_04889</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS31"/>
    <dbReference type="PaxDb" id="5476-C4YS31"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04889"/>
    <dbReference type="HOGENOM" id="CLU_009902_4_2_1"/>
    <dbReference type="OMA" id="DSGLWGF"/>
    <dbReference type="OrthoDB" id="10251424at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000001">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF126">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="3">
        <location>
            <begin position="32"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="4">
        <location>
            <begin position="177"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ46534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="439" mass="47916" checksum="CCC6580AC3F3AB7C" modified="2009-07-28" version="1">MIRGSSALKSLTSRRLYSTGVKYTTLSNGVTVATETNPTAKTSSVGLFFGAGSRSEHSHSNGISALTTNVLASQSAKGSLLTAKNDREFNGIIAQTTNDNITEAGKLIASIASNAVDIVEKTDLTKHKQYLSAQASAVEADPKSKVLSHLYSSAFQGYSLALPTLGTTESVENLENQDSLRHLAKHLVNNNTVIAASGNFDHDKLADAIEANLKIAEGVKPEIKPASFLGSEVRMRDDTLPKAYISIAVHGEGLNSPNYYLAKVAAAIYGDFYLHSTIAKFTSPKLASIVQEYNIVESYNHYSKSFSDTGIWGYYAEIADKFTVDDFTHFSLKEWNRLSISISEAEVARAKAQVKTALAKELADSSAVTSDIAEKVLLVGHRQSLREAFEKIDAIKVNDVKEWGKSKVWDRDIVISGTGLIEDLLDYNRNRNEMAMMRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSE6</accession>
    <name>C4YSE6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3074 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSE6"/>
    <dbReference type="PaxDb" id="5476-C4YSE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05011"/>
    <dbReference type="HOGENOM" id="CLU_078586_1_0_1"/>
    <dbReference type="OMA" id="KWIMATT"/>
    <dbReference type="OrthoDB" id="6423603at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024500">
        <property type="entry name" value="DUF3074"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370:SF1">
        <property type="entry name" value="DUF3074 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11274">
        <property type="entry name" value="DUF3074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3074" evidence="1">
        <location>
            <begin position="54"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="229" mass="25833" checksum="2EBB27EF27F88F35" modified="2009-07-28" version="1">MPSSERDTLLAESKTILKSVTNWKPGKQFKSNVIPETITTSTYSTTNIKDNQFWCARESLIPSAYKQKVIDCLIGTANIGSTHSDHEVNYVEEFDSLKISNVTEYPDGGWSYELHANYKFGTIGISNRMFYESVHIYKFDKNNQAEEDDKDTNCAYIISVPIDGPTGNFVIGKYHSIEKISWSDNKDSDLKWIMATTSDAGGYLPRWLTNMILPGAISNDVPSVLKYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSS0</accession>
    <name>C4YSS0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSS0"/>
    <dbReference type="PaxDb" id="5476-C4YSS0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05139"/>
    <dbReference type="HOGENOM" id="CLU_037539_0_0_1"/>
    <dbReference type="OMA" id="MNDYVTF"/>
    <dbReference type="OrthoDB" id="2163387at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="397" mass="42176" checksum="B600131CF183850A" modified="2009-07-28" version="1">MSATIIDNGQPKAKTPLKKEELEQIARQLKKKLSKASITAKQSLSPTNIKTSTTIALPKSSPLKSYIMKNNSNDHSPTNNISNLSSSPINLYSPNGKSPTHIRTPAAAFLSCSPLKNVSHADTSADDMLDSPTKRRKTSPRKMVLQEITPEKVKKESTLKPSLELTSTSTKKKPESPSKDKTTTPTMAKRELSSQSSTSSSAQNALLKTPKQNSNGNGYNDAEGADLLMYLATSPSPARPYLSNTPRVMNKPLPSISQSSISQSSQPSQSQSQSQSQSQTSTTSASASASANASSSAGSGSAANASSSSSSSSFLAPPPPVTPKRVINSHSTRTPQNRLTPFFNTLNANGLPSQGLALTPTSFNMNDYVTFFTPSPGGAFNKNLLKTPDFHNSLSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSS1</accession>
    <name>C4YSS1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase</fullName>
            <ecNumber evidence="3 12">2.4.1.131</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_05140</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:29523"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="EC" id="2.4.1.131"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11 12">
            <dbReference type="Rhea" id="RHEA:29524"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.131" evidence="3 12"/>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSS1"/>
    <dbReference type="PaxDb" id="5476-C4YSS1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05140"/>
    <dbReference type="HOGENOM" id="CLU_017896_1_1_1"/>
    <dbReference type="OMA" id="WKHFTLI"/>
    <dbReference type="OrthoDB" id="2276068at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03806">
        <property type="entry name" value="GT4_ALG11-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000256">
        <property type="entry name" value="GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031814">
        <property type="entry name" value="ALG11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919:SF1">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15924">
        <property type="entry name" value="ALG11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 12 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ALG11 mannosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="109"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="13">
        <location>
            <begin position="343"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF15924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ46774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="609" mass="70975" checksum="D066A3A7D2995446" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSZ3</accession>
    <name>C4YSZ3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ethionine resistance-conferring protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_05690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSZ3"/>
    <dbReference type="PaxDb" id="5476-C4YSZ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05690"/>
    <dbReference type="HOGENOM" id="CLU_012893_1_2_1"/>
    <dbReference type="OMA" id="WFFVWKL"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="506"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ47129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="619" mass="68067" checksum="88C327EDD1787B76" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT10</accession>
    <name>C4YT10_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_05708</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nitronate monooxygenase family. NMO class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT10"/>
    <dbReference type="PaxDb" id="5476-C4YT10"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05708"/>
    <dbReference type="HOGENOM" id="CLU_038732_5_0_1"/>
    <dbReference type="OMA" id="NLFCHAP"/>
    <dbReference type="OrthoDB" id="10265891at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42747">
        <property type="entry name" value="NITRONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42747:SF3">
        <property type="entry name" value="NITRONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ47146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="440" mass="50036" checksum="F7274416854C99DC" modified="2009-07-28" version="1">MSISTRLKLVSKLGIDYPIFLSPMAGVSTIDMSIGVSNNGGLGSIPLASIDFRKQDSIEKLENLIIEYKKKLINSTTTKTKTKTKDNDQLVVNLNFFCHEIENEPNQQQINNWKQLYKQSVFDNNTEDDDAFKLLDEIQFINGNVSFKEIENNENHIDQYNKLMEYLEQLKPSIISFHFGMPSPKTIKRLQNQGIMIFITSTSLEETIYLTNNNNNNNNNNNNNDDDDAKIDGIILQGYEAGGHRGNFLISDDKFDEKLSTHSLFIQSKQYLDENVTTGYKPYLVPAGGIIDIDTINYYLSLGADAVQMGTAFLATPECINHKFFNTNNISGQRKPTIMIDLVSGKFARTVTTDFITNLIKNGNNNNNYYTKNELPSYGYAYHGYKSLKSIIKNHTKNIKDIKDIGFYLAGQNYYQIEKNKSTQEIMKILTNGIDRDVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTE2</accession>
    <name>C4YTE2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_05431</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTE2"/>
    <dbReference type="SMR" id="C4YTE2"/>
    <dbReference type="PaxDb" id="5476-C4YTE2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05431"/>
    <dbReference type="HOGENOM" id="CLU_118853_4_1_1"/>
    <dbReference type="OMA" id="RYKFEAW"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000010">
        <property type="entry name" value="Acyl-CoA-binding domain-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022408">
        <property type="entry name" value="Acyl-CoA-binding_prot_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00880">
        <property type="entry name" value="ACB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="2"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ46883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="86" mass="9901" checksum="51C0DBE483C78AA6" modified="2009-07-28" version="1">MVSAEFEEKANQVSNLSKRPSDDELLKLYGLYKQATVGDNNTDKPGTFDFKGKYKWQAWKDLEGKSQEDAEKEYIDLATELISKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTI1</accession>
    <name>C4YTI1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTI1"/>
    <dbReference type="PaxDb" id="5476-C4YTI1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05474"/>
    <dbReference type="HOGENOM" id="CLU_072845_0_0_1"/>
    <dbReference type="OMA" id="NCHASIK"/>
    <dbReference type="OrthoDB" id="340681at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006886">
        <property type="entry name" value="RNA_pol_III_Rpc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES III 80 KDA POLYPEPTIDE RNA POLYMERASE III SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04801">
        <property type="entry name" value="RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="278" mass="31693" checksum="044EA9BF6D32FAE1" modified="2009-07-28" version="1">MSSLFINEEDDMTPEPYKPSTSTIREEEEEVQVKQEFPDEKMVDPDEDDPIVESIPLLINTVPERAKQSLHVLQYAGRPKSRPNRAGNCHASIKPESQYLQVKVPLDTERFFNVDKIQEWGEQIVEQTISGVLDGSYEVGNYAAKIINDSDGRRVVLIPVDSTVQLKPSFKYIDDLEAQSIQQRRQQESTNEKPANVQILQSAAKHSTQSGEFSHSLGDSLKSVKHFEEEEWQNLIWKRGDDDVTKSIKFGLDHHTDANIGLKTNTSYDEYIDMLINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTP5</accession>
    <name>C4YTP5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tom7p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_05540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTP5"/>
    <dbReference type="PaxDb" id="5476-C4YTP5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05540"/>
    <dbReference type="HOGENOM" id="CLU_173610_1_1_1"/>
    <dbReference type="OMA" id="FILYLGW"/>
    <dbReference type="OrthoDB" id="284357at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012621">
        <property type="entry name" value="Tom7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944:SF2">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08038">
        <property type="entry name" value="Tom7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ46986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="65" mass="7179" checksum="5F4400457BAD84F0" modified="2009-07-28" version="1">MAGESSVSKFQITLSDESKERIIKLLDYSKTVAHYGFIPFVSYLGWSATPNKPSILNLLSPFPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTR3</accession>
    <name>C4YTR3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_05558</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51220"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:34718"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:133977"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 glutathione + H2O2 = glutathione disulfide + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.11.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTR3"/>
    <dbReference type="SMR" id="C4YTR3"/>
    <dbReference type="PaxDb" id="5476-C4YTR3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05558"/>
    <dbReference type="HOGENOM" id="CLU_1686316_0_0_1"/>
    <dbReference type="OMA" id="YACYELD"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000026">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF26">
        <property type="entry name" value="GRX1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="8">
        <location>
            <begin position="74"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ47004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="156" mass="17779" checksum="6BA47C9B9702F6D8" modified="2010-10-05" version="1">MDYFQTEKTTETRQQRQQKKRPVRNSIICTLSLSYQPNFVMSSLIGWLSSWFQNEPITPELKKEIESNINSHKVLVYSKSYCPYCTSTKTLLQSLNQDYKVIELDQIPKGSAIQNGLQELTGQRTVPNVFINGKHIGGNSDIQALHSQGKLKPLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTX4</accession>
    <name>C4YTX4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Programmed cell death protein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTX4"/>
    <dbReference type="PaxDb" id="5476-C4YTX4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05620"/>
    <dbReference type="HOGENOM" id="CLU_1474974_0_0_1"/>
    <dbReference type="OMA" id="XSSSAAX"/>
    <dbReference type="OrthoDB" id="443682at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524:SF1">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23050" checksum="6EA4054B96F88034" modified="2009-07-28" version="1">MSANDEYSSDEESFDESTKSKVLLGFVDVPIISDGKDPEDNDLPTIEDTFIGGQPVWLHPDSKPAEKSLTCDVCNGKLALYLQAFAPIDGKLYDRVIYVFGCKNTKSCSGKKGTVKVIRGIIKDSETVNRIKKENQEALQKDMEAKLKLEKQKKFNDELTKDLFKKKDTPEASNPFGGNSNPFSNPFGSNPFSKKPEEEKEEEKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCN9</accession>
    <name>C4YCN9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_00273</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCN9"/>
    <dbReference type="PaxDb" id="5476-C4YCN9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00273"/>
    <dbReference type="HOGENOM" id="CLU_021458_6_1_1"/>
    <dbReference type="OMA" id="HDLCQVT"/>
    <dbReference type="OrthoDB" id="10030083at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000017">
        <property type="entry name" value="Diacylglycerol pyrophosphate phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="111"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ42075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="284" mass="31999" checksum="1A9F5E3CEB42A393" modified="2009-07-28" version="1">MTFLNPSSIVKYTQSNQFHDFIPDWIVATVTVLFFFSVAETALPFQRQFSLDDLTISHPFAIKERVSGILCIEIAAFVPLFVILTSLLVKYQQGAFSSHQQALHCLQISVLGLIISLSLNGVITDILKIWIARPRPDFLERCGPAPGTPLHELVDVNVCTAPLDKALLIDGMKSTPSGHSSISFGGLFYLTLWLLGQFKLFQNRESPQYVYKYFLAFSPLSLATYIALSRTQDYRHHFTDIVLGGAIGISFAWWSYHHYFNKLVSEESHKPIDSETLTESLLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCP4</accession>
    <name>C4YCP4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipase</fullName>
            <ecNumber evidence="7">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_00278</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="7"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YCP4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00278"/>
    <dbReference type="HOGENOM" id="CLU_000690_3_2_1"/>
    <dbReference type="OMA" id="DSLWTKH"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01254">
        <property type="entry name" value="PH_PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000011">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="9">
        <location>
            <begin position="750"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="9">
        <location>
            <begin position="1060"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="352"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1239"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1505"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1242"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1519"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1557"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1590"/>
            <end position="1606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ42080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1710" mass="196082" checksum="CAFF76445C514C4F" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD80</accession>
    <name>C4YD80_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Lipase</fullName>
            <ecNumber evidence="12">3.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_00470</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:12045"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the AB hydrolase superfamily. Lipase family. Class Lip subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="12"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD80"/>
    <dbReference type="SMR" id="C4YD80"/>
    <dbReference type="ESTHER" id="canal-LIP6">
        <property type="family name" value="Fungal-Bact_LIP"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YD80"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00470"/>
    <dbReference type="HOGENOM" id="CLU_029538_5_0_1"/>
    <dbReference type="OMA" id="RQYCATG"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.130:FF:000001">
        <property type="entry name" value="Lipase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013435442" description="Lipase" evidence="12">
        <location>
            <begin position="17"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR029171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ42266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="463" mass="50480" checksum="21F5E66B04F73DAF" modified="2009-07-28" version="1">MRDLILFLSLLHTIFASLFSLKPPSQDDFYKAPAGFKAAKPGDILKTRKSPNKPSSLYAPVDVQNSWQLLVRSEDSFGNPNAFVTTIIQPKNADPSKVVSYQNWEDASNINCSPSYGSQLGAPLSTILTQLDMTFIVPPLKSGYYVVLPDYEGPKSTFGVGRQSGKATLDSIKAVLKTKDFSGINDDAKVVLWGYSGGSFASGWAAVLQPEYAPELKDNLIGAALGGFAANLTGIAESVDGEVFSGFIPLALNGIANEYPDFKKRLYEEVKPGAKADLQKGAENCLAASLISYPMYQYFTGPRRVFEKGWSLLEDKTIGKTLEDNLLIALSKEHMPQIPIFVYHGTIDKIIPIKDSIKIYKNWCDWGIGSFEFSEDKSNGHTTETVVGAPAALTWIDARFAGKPAVEGCSFTTRASNFLYPNISESAASYFKGIYQTILRSKLGSGVTSDDVSVNGLRSLYHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD94</accession>
    <name>C4YD94_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoporin NUP188</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_00484</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Nup188 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YD94"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00484"/>
    <dbReference type="HOGENOM" id="CLU_001029_1_0_1"/>
    <dbReference type="OMA" id="HSWKFFA"/>
    <dbReference type="OrthoDB" id="102511at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.70:FF:000007">
        <property type="entry name" value="Nup188p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018864">
        <property type="entry name" value="Nucleoporin_Nup188_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044840">
        <property type="entry name" value="Nup188"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041634">
        <property type="entry name" value="Nup188_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048883">
        <property type="entry name" value="Nup188_N-subdom_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431">
        <property type="entry name" value="NUCLEOPORIN NUP188 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18378">
        <property type="entry name" value="Nup188_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10487">
        <property type="entry name" value="Nup188_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21093">
        <property type="entry name" value="Nup188_N-subdom_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal" evidence="11">
        <location>
            <begin position="50"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal subdomain III" evidence="13">
        <location>
            <begin position="562"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear pore protein Nup188 C-terminal" evidence="12">
        <location>
            <begin position="1280"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ42280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1587" mass="179743" checksum="E766B6B99FFDFD69" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDB8</accession>
    <name>C4YDB8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_00508</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDB8"/>
    <dbReference type="PaxDb" id="5476-C4YDB8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00508"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="OMA" id="WCILAFG"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000014">
        <property type="entry name" value="MFS drug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="552"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="79"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="577"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="577"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ42304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="620" mass="67470" checksum="19D89B6C1984EB3C" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDF5</accession>
    <name>C4YDF5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ornithine cyclodeaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_00549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDF5"/>
    <dbReference type="PaxDb" id="5476-C4YDF5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00549"/>
    <dbReference type="HOGENOM" id="CLU_042088_0_1_1"/>
    <dbReference type="OMA" id="CVGMGLM"/>
    <dbReference type="OrthoDB" id="41492at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000556">
        <property type="entry name" value="Proline utilization protein PrnX-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1780.10:FF:000014">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ42341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="38293" checksum="EC7984D4C17B40BE" modified="2009-07-28" version="1">MKVISDQAVTEFLNKTLSKESILDAFQPTLLKSLTTYSQDSDHIVPPRTVQPSNNPNSDTTHIYMPCISPDEVGLKVISGGPGNNSKGLGFQGCVLIMDEVTGQLKAVLNANNLTAFRTALASSLGLTKLIAPSNANILPELSAFGVGLQAYWHIKLALLLYEGKIKEVNILNRTLKNAETLADRLSKEFKNVKFNSFSYQDESSGFIPHVQNSSIIFGCTPATSPIIKKEYLNTNPEVPKFISLIGSYKPHMIELDLNLCKELKQKGISIIVDSKEHTLHEAGELIQAEFDEIQLIEIHELCADFDATVTDKSTGITVQKIVGLSIMDLSIGKMISNEIGNNAVVVDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDG0</accession>
    <name>C4YDG0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDG0"/>
    <dbReference type="PaxDb" id="5476-C4YDG0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00554"/>
    <dbReference type="HOGENOM" id="CLU_142418_0_0_1"/>
    <dbReference type="OMA" id="HEVIVDH"/>
    <dbReference type="OrthoDB" id="3994490at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018555">
        <property type="entry name" value="C630.06c-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09428">
        <property type="entry name" value="DUF2011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="156" mass="18844" checksum="CC04E72EC19C125B" modified="2010-10-05" version="1">MKVSLREQSEERVINERPESFYFAKYTDKQREQFQQCAVSSDDIYQQMYIVDTRPWKCLNLNEYNAKIESEIARQKAKCRKNRPGKKKRQLKIVCRQRKLEKAKMKKLEEEKLKKLMKKQKFQQKFNGKPNQRQGKGRKPMAGNKKQPPKPKYRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDH4</accession>
    <name>C4YDH4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDH4"/>
    <dbReference type="SMR" id="C4YDH4"/>
    <dbReference type="PaxDb" id="5476-C4YDH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00569"/>
    <dbReference type="HOGENOM" id="CLU_018149_0_0_1"/>
    <dbReference type="OMA" id="HEEYIQH"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012104">
        <property type="entry name" value="PHO85_cyclin_1/2/9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016511">
        <property type="entry name" value="Cyclin_Pcl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="1">
        <location>
            <begin position="50"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="254" mass="28971" checksum="A48D17B4FC9D6199" modified="2010-10-05" version="1">MSDKEALKIFSRQPVSQDMVNFLVATTNSIIQVKPSKRNQHHRKLSSTSSTIISPYNHSISLTNFIKNLINYSNVQTPTLMATIVYLNKLRNLLPANAIGMETTRHRIFLSALIVAAKSLNDSSPLNKHWTKYTDGLLTLEEVNLAERELLNILNWKTNITKEELIISLYPFLQPIIRQHEEYIQHQQYKIRMMQKSKAVGSSNSIESKLSLHSSSSSESLYSDNLSESSYNSIPIKKKRSMISIVDSTILYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDH9</accession>
    <name>C4YDH9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_00574</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDH9"/>
    <dbReference type="SMR" id="C4YDH9"/>
    <dbReference type="PaxDb" id="5476-C4YDH9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00574"/>
    <dbReference type="HOGENOM" id="CLU_126124_0_0_1"/>
    <dbReference type="OMA" id="DYAYKAP"/>
    <dbReference type="OrthoDB" id="2098203at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3440:FF:000001">
        <property type="entry name" value="Mitochondrial ribosomal protein L40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019192">
        <property type="entry name" value="Ribosomal_mL40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042831">
        <property type="entry name" value="Ribosomal_mL40_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39150">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39150:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09812">
        <property type="entry name" value="MRP-L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ42365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="147" mass="17164" checksum="FDC62182D91A6126" modified="2010-10-05" version="1">MFNPLNKPTTTSNVIKHFVRGKRQATELNIATQKIVNQLSVLSASRKQPKLLKLCNEDFIKHKTIMNAWKLLQRRRITQQSEKLSKQYKSIVNAMEDLKQTSPELFEAANAKNPKRFTTFPIEMRVPTDYPPNKPWTYNFVPSKTHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDN7</accession>
    <name>C4YDN7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDN7"/>
    <dbReference type="PaxDb" id="5476-C4YDN7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00634"/>
    <dbReference type="HOGENOM" id="CLU_653796_0_0_1"/>
    <dbReference type="OMA" id="NTIAKNW"/>
    <dbReference type="OrthoDB" id="10397806at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="387" mass="44776" checksum="C7E8FF11AE0A435C" modified="2009-07-28" version="1">MESPELFQFKDYTEAVPSKDVDLIVGFIKKKHYKKWLKSINLEYRWLKKTRIYSTSNNDKDTPQKRPKKSSYLKEYYFHCSSSGTYTLKLQQGPESRYKTPRSLSSIKTACTAKVYIKKPKSMPKSYLIGIMPRHNHPPIKYKGPLNTIAKNWLDEKVKMGYTKAQIKEALKKAEEQYKDSPNFKPLLQIQNYHIEYRIRHHGNNSNESNEDPSTNINDSDIDYSFIDDICDSSDNSDSSESQIDDNDNSANNIENHDSTENHITSTNFNNGTISGEQPIQYVNNSPPPPPPSPPPPMTRNWNPHLLQSTCFGKNLYELTKEQKVGECLHLLNTTFNWFDMIVKSSPEKIDESIGYIKGLERYMSSLATGVQYPWHVDEYGRPMYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDP3</accession>
    <name>C4YDP3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_00640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the MSS1-MTO1 complex that catalyzes the 5-carboxymethylaminomethyluridine (cmnm(5)U) modification at the 34th wobble position (U34) of mitochondrial tRNAs.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmG family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDP3"/>
    <dbReference type="PaxDb" id="5476-C4YDP3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00640"/>
    <dbReference type="HOGENOM" id="CLU_007831_2_2_1"/>
    <dbReference type="OMA" id="CNPAMGG"/>
    <dbReference type="OrthoDB" id="3329at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070899">
        <property type="term" value="P:mitochondrial tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000145">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.570:FF:000001">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000002">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="entry name" value="GidA associated domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049312">
        <property type="entry name" value="GIDA_C_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047001">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00136">
        <property type="entry name" value="mnmG_gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="GLUCOSE INHIBITED DIVISION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21680">
        <property type="entry name" value="GIDA_C_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="SAM_GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01228">
        <property type="entry name" value="GIDA_assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain" evidence="7">
        <location>
            <begin position="596"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ42429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="695" mass="77538" checksum="345EF0878DFF91AF" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDP5</accession>
    <name>C4YDP5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
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            <strain evidence="2 3">WO-1</strain>
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    </feature>
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            <end position="88"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="114"/>
        </location>
    </feature>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="EEQ42431.1"/>
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    </evidence>
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    </evidence>
    <sequence length="207" mass="23080" checksum="34C0C60431807CAC" modified="2009-07-28" version="1">MVEKNLIGEVFLNGIEKSIKKKKEKSLKSTAVDGKESPDRALEKETTQSDSAKIKTKEENEAEQTTKEKSEKESKEKTEDDGDIKTDEANVNSLDQAEEKIDEPQSESKEKEPESNEEDDDNGKTEIVNGTTSITKTQALSIIANYTFLLHFLNSKVDLEDIESVTQLIKTHYGADIETSSIKIVIDGVGSFYKSQKSVYLPLSIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
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                <person name="Hube B."/>
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            <dbReference type="PubMed" id="19465905"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="kup"/>
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    </evidence>
    <sequence length="808" mass="89964" checksum="70F84DB08396B259" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YE77</accession>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
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                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
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                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
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                <person name="Lorenz M.C."/>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">WO-1</strain>
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    </reference>
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        <location>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5002946381" evidence="1">
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            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42613.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="131" mass="13465" checksum="2D3DD1867DB4652D" modified="2009-07-28" version="1">MHFSKIIAGSALSSVALAEFQNGTVTTHVTATGYTTYCPYPTTITLTICEEENICTKRPIVVSEPTTVTVTEPCIISTSYETTEVIATTTLPSSLSPSSVAPANVTSFEGAGSKNVAGALVGVVAIAAAMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEE7</accession>
    <name>C4YEE7_CANAW</name>
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        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
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                <person name="Santos M.A."/>
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                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
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                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
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                <person name="Hube B."/>
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                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEE7"/>
    <dbReference type="PaxDb" id="5476-C4YEE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00904"/>
    <dbReference type="HOGENOM" id="CLU_1175261_0_0_1"/>
    <dbReference type="OMA" id="PRFSNIC"/>
    <dbReference type="OrthoDB" id="4027021at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ42683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="233" mass="27426" checksum="8B267F52480874F1" modified="2009-07-28" version="1">MKSTPVSIIDFPDELLEKIIRSLNQKDLIQLALTHPRFSNICQLSLLRHIYIYNDDKYFKFTKKATYIQEYLHMTTVGLSNFLKLLTSPNFQPSLTKEIVIANDDNAYLQYFELMERQQLPVKYDRIKDIDVRNWLREVKPSRKTKLAMELAELKRRSQFVADINRNKTDYYDSNDQFIVVIAIIFVFVGVLVFIVMWGNKWDLQMMNSFLTGSIPFGISKIENAKKLFASLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEL6</accession>
    <name>C4YEL6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoporin POM33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_00973</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PER33/POM33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEL6"/>
    <dbReference type="PaxDb" id="5476-C4YEL6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00973"/>
    <dbReference type="HOGENOM" id="CLU_065417_1_0_1"/>
    <dbReference type="OMA" id="RAYVWIT"/>
    <dbReference type="OrthoDB" id="5581259at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051645">
        <property type="entry name" value="PER33/POM33_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005344">
        <property type="entry name" value="TMEM33/Pom33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03661">
        <property type="entry name" value="TMEM33_Pom33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ42752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30580" checksum="DA8776C0514D9A4C" modified="2009-07-28" version="1">MAEEKKAGGGGSAAAAAPAIKFDQDKLLKTVQTLQFGWFVGNVLTLLGFFLFTLSYFGILPDVGFVWYLISLLGALISFGILLVQFIQKNGFKVPLLIKDDNFHYFLLAFFLIAMRAYVWITLVPFVIFSSFHVLNYVNTHLLPIVGLDGNNPISKHITTFVNKNNLASIQIASGIELLTVVWLFLRMITFRKRSLTPFLVFLVFLKKRHEVSPFTRKYFDFFAAQGDSIVSTINNPVINDVWGHVKTAFRTIDSFKLVHDRTKDEDKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEP4</accession>
    <name>C4YEP4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Defect at low temperature protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DLT1</name>
        <name evidence="9" type="ORF">CAWG_01002</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Required for growth under high-pressure and low-temperature conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DLT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEP4"/>
    <dbReference type="PaxDb" id="5476-C4YEP4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01002"/>
    <dbReference type="HOGENOM" id="CLU_402765_0_0_1"/>
    <dbReference type="OMA" id="QWIYSIS"/>
    <dbReference type="OrthoDB" id="4096362at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038869">
        <property type="entry name" value="DLT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021:SF1">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="548"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="621"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="664"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="674"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="689"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ42780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="699" mass="81102" checksum="A0ED2B9C0558192A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEP7</accession>
    <name>C4YEP7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEP7"/>
    <dbReference type="PaxDb" id="5476-C4YEP7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01005"/>
    <dbReference type="HOGENOM" id="CLU_2209651_0_0_1"/>
    <dbReference type="OMA" id="YRFHLIM"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946726" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="12640" checksum="5A1B4E77F9BD48E3" modified="2009-07-28" version="1">MVCSLYCSLILLFTCTISYPKFHKTPPRNVQTKRRYLSLLSKTSKFQVSVIHAEEQCLIRYSRFVFLESIAGFAYRFHLIMNVTTCARVCVVRFQTYLRTIHYITNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEW7</accession>
    <name>C4YEW7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Septum-promoting GTP-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEW7"/>
    <dbReference type="PaxDb" id="5476-C4YEW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01076"/>
    <dbReference type="HOGENOM" id="CLU_041217_0_2_1"/>
    <dbReference type="OMA" id="IWDRIFL"/>
    <dbReference type="OrthoDB" id="6585768at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017231">
        <property type="entry name" value="Small_GTPase_Tem1/Spg1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037527">
        <property type="entry name" value="Small_GTPase_Tem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="170" mass="19566" checksum="5A98B7C2CEE95835" modified="2009-07-28" version="1">MVKYVEGSFDEDYIQTLGVNFMDKKIQIRNTTITFSIWDLGGQKEFINMLPLVSNDAVAILFMFDLTRKSTLNSIKEWYRQVRGFNKTAIPFLVGTKYDQFIDLSFQDQIEITQQAKKFGSAMKAPVIFCSTSHSINVQKIFKIILSKAFDLKLNLDEIVNVGEPILIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEZ9</accession>
    <name>C4YEZ9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Chromatin structure-remodeling complex subunit RSC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_01108</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RSC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEZ9"/>
    <dbReference type="SMR" id="C4YEZ9"/>
    <dbReference type="PaxDb" id="5476-C4YEZ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01108"/>
    <dbReference type="HOGENOM" id="CLU_007728_2_1_1"/>
    <dbReference type="OMA" id="FFKYESP"/>
    <dbReference type="OrthoDB" id="1742084at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04717">
        <property type="entry name" value="BAH_polybromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05521">
        <property type="entry name" value="Bromo_Rsc1_2_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05522">
        <property type="entry name" value="Bromo_Rsc1_2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.490:FF:000016">
        <property type="entry name" value="RSC complex member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048047">
        <property type="entry name" value="RSC1/2_bromodom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035700">
        <property type="entry name" value="Rsc1/Rsc2_Bromo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF21">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
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        </location>
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            <end position="489"/>
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            <end position="176"/>
        </location>
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    </feature>
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            <end position="705"/>
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            <end position="163"/>
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            <end position="203"/>
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    </feature>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="795" mass="89915" checksum="D1AB09540E4E632B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFH2</accession>
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    </organism>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
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                <person name="Sherlock G."/>
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                <person name="Berriman M."/>
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                <person name="Lorenz M.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">WO-1</strain>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
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        </lineage>
    </organism>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
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                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
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                <person name="Hube B."/>
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                <person name="Logue M.E."/>
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                <person name="Neiman A.M."/>
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                <person name="Shah P."/>
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                <person name="Staggs R."/>
                <person name="Stansfield I."/>
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                <person name="Berriman M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
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        <property type="component" value="Chromosome 1"/>
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        <source>
            <dbReference type="EMBL" id="EEQ41820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="104" mass="11687" checksum="DAAA31F78B9B030C" modified="2009-07-28" version="1">MKKYDGETKTQGENDVKTYKVVVPPKYLVVVLEGVGVVKLPSMLDVSGTKYEMVSAIKKSSGWAVSLRSESGWVSIEDLQVKSQSSELLFLDKNYIVVWRLSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGC2</accession>
    <name>C4YGC2_CANAW</name>
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            <fullName evidence="6">Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
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        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
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                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
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                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="PaxDb" id="5476-C4YGC2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00244"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ42046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="170" mass="18725" checksum="E13D45625DBD7E98" modified="2009-07-28" version="1">MTTGALPSTPANEPLIKSADNVANLIESFIELGVLVHDNQGTPQSNQALMNKLNQLISQLSQTSITANDPNDANTNLKQFLIPIDVISYIEDGRNPDIYTREFIEVNAKSNARLKGKMLGFKKLRDVFGDKLKQEFPQLEKGVDDIINRTNDNSSHIASVITDTANNNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGS0</accession>
    <name>C4YGS0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_03252</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGS0"/>
    <dbReference type="PaxDb" id="5476-C4YGS0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03252"/>
    <dbReference type="HOGENOM" id="CLU_012844_0_0_1"/>
    <dbReference type="OMA" id="SCAQIAP"/>
    <dbReference type="OrthoDB" id="762982at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF88">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="85"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ44952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="970" mass="110732" checksum="89F7DB274D8EE233" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGT2</accession>
    <name>C4YGT2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Opaque-phase-specific protein OP4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_03264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGT2"/>
    <dbReference type="PaxDb" id="5476-C4YGT2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03264"/>
    <dbReference type="HOGENOM" id="CLU_061591_0_0_1"/>
    <dbReference type="OMA" id="FRREYMM"/>
    <dbReference type="OrthoDB" id="4017194at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946630" description="Opaque-phase-specific protein OP4" evidence="2">
        <location>
            <begin position="21"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="34935" checksum="BF79B6C260682FE8" modified="2010-10-05" version="1">MKLDFATATLVLAAISSVAAAPAADAQVKVTQLTVRESNLVNSALANLQHYNAKRDLMSQEEIIKRENQIVTDVLTAIKNTNLSPGIIKYLITDPTLSKISVDVIVGAIKNGTINLTTLLKSLNDSGLAVDLIKDLINDCAFYAYIYKAILDKLTSLPNLIGNALGLNANTVSSKMASAKREIMVESAPEPIYARDGQDVLTSLMESLKSSGLANQVVEALVIDDQFYKWGGDLIKELIDEKAITLGQLIDALADSGLIPSLFQAFLNFGTLKSVIVTALAAAFGKCQNATPTSSLKTTPTGTATVSIPTATGTSGPVTCKKKKRRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH11</accession>
    <name>C4YH11_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ceramide very long chain fatty acid hydroxylase</fullName>
            <ecNumber evidence="18">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CAWG_03352</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="18"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YH11"/>
    <dbReference type="SMR" id="C4YH11"/>
    <dbReference type="PaxDb" id="5476-C4YH11"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03352"/>
    <dbReference type="HOGENOM" id="CLU_034756_0_1_1"/>
    <dbReference type="OMA" id="WTIIEYV"/>
    <dbReference type="OrthoDB" id="2204368at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005149">
        <property type="entry name" value="IPC-B_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17 18" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 20" id="KW-0349">Heme</keyword>
    <keyword evidence="14 18 20" id="KW-0408">Iron</keyword>
    <keyword evidence="5 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 19" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="22">
        <location>
            <begin position="5"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR005149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EEQ45043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="378" mass="44426" checksum="361C944030A58417" modified="2010-10-05" version="1">MSKNLPLLSIQEVSKHNHVKDCWVTLYQRKIYNVTGFLEEHPGGGEIILPYAGKDITEIMADIQSHQHSESAYEILDEGMLVGYLATEQEEKGLLRNKNNTPVEVKLVNKDDKDFDMYEFHDHLPAEEKLSIQTDFEEDSKKHRFLDLNKPLLMQLLTSNFSKEFYLDQVHRPRHYGKGSAPLFGNFLEPISLTPWWVIPLVWLPPNFYLFYVGFVNQSPITALSLWVMGLFIWTLVEYCLHRFLFHLDYFLPDHPYAFALHFLLHGIHHYLPMDGYRLVLPPTLFLVLAYPFYKLIFSIFPFYMACSGFAGGTLGYIMYDITHYVLHHTKLPKYFQTVKRLHLEHHYKNYELGFGVTSPFWDVVFGTELTNTFEKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH30</accession>
    <name>C4YH30_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_03371</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YH30"/>
    <dbReference type="PaxDb" id="5476-C4YH30"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03371"/>
    <dbReference type="HOGENOM" id="CLU_001570_2_4_1"/>
    <dbReference type="OMA" id="DPRAYWQ"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF9">
        <property type="entry name" value="P450, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="523"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ45062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="69048" checksum="A2C1753D35E82B3E" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH62</accession>
    <name>C4YH62_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="10">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_03403</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="10"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YH62"/>
    <dbReference type="SMR" id="C4YH62"/>
    <dbReference type="PaxDb" id="5476-C4YH62"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03403"/>
    <dbReference type="HOGENOM" id="CLU_012907_1_1_1"/>
    <dbReference type="OMA" id="WYANCPG"/>
    <dbReference type="OrthoDB" id="10266385at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000006">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006667">
        <property type="entry name" value="PRK09212.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008854">
        <property type="entry name" value="PRK11892.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="9 10 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="11">
        <location>
            <begin position="52"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ45094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="379" mass="41294" checksum="E8DB49D7615F6E8E" modified="2010-10-05" version="1">MSSLSSVTRSAKLATQSLKYNTRPSLSKIGQFQTSKITYRANSTQSTPVKEITVRDALNQALSEELDRDEDVFLMGEEVAQYNGAYKVSRGLLDKFGEKRVIDTPITEMGFTGLAVGAALHGLKPVLEFMTWNFAMQGIDHILNSAAKTLYMSGGKQPCNITFRGPNGAAAGVAAQHSQCYAAWYGSIPGLKVLSPYSAEDYKGLLKAAIRDPNPVVFLENEIAYGETFKVSEEFSSPDFILPIGKAKIEKEGTDLTIVGHSRALKFAVEAAEILEKDFGIKAEVLNLRSIKPLDVPAIVDSVKKTNHLVTVENGFPGFGVGSEICAQIMESEAFDYLDAPVERVTGCEVPTPYAKELEDFAFPDTEVILRACKKVLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH84</accession>
    <name>C4YH84_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_03428</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YH84"/>
    <dbReference type="PaxDb" id="5476-C4YH84"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03428"/>
    <dbReference type="HOGENOM" id="CLU_046570_1_0_1"/>
    <dbReference type="OMA" id="INKRWHW"/>
    <dbReference type="OrthoDB" id="272245at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000030">
        <property type="entry name" value="Exosome complex component RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="31"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="209"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ45116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="307" mass="34540" checksum="8C4F935F243A05C7" modified="2009-07-28" version="1">MVQLSPAEKSYLYDSLTQQPIIRPDLRSIHQYRPLVAKTSFLPGSNGSARVRTEDGSECIVSVKSKVVLISEEEEVQQQQGHNLIEVDIDIVGHRDDSNYVANLKFQLTNLLQQNFPFEVLKLTSKYTFKLYIDCIIISHSCYPLSLISIANYLALKTTRLPLLISDVNDEEIAELPTFSDDWENAKLIQDYHLNANTRGGGSSTKFQPPIFITIGVIGKNLILDPSFEEEQVLENGLIISFYNNKVITPISNTNFAVNSNNSNFKGLDQSLLIQSLTLCNKYCPNIIRALDSLIEEDNDDNDSSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHA4</accession>
    <name>C4YHA4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_03449</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHA4"/>
    <dbReference type="PaxDb" id="5476-C4YHA4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03449"/>
    <dbReference type="HOGENOM" id="CLU_007105_4_0_1"/>
    <dbReference type="OMA" id="SYFVRWV"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035621">
        <property type="term" value="P:ER to Golgi ceramide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13289">
        <property type="entry name" value="PH_Osh3p_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000013">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041680">
        <property type="entry name" value="PH_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF203">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15409">
        <property type="entry name" value="PH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="195"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="392"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ45136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="843" mass="95035" checksum="B69C693539CF2284" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHA8</accession>
    <name>C4YHA8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA repair protein RAD2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_03453</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHA8"/>
    <dbReference type="PaxDb" id="5476-C4YHA8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03453"/>
    <dbReference type="HOGENOM" id="CLU_003018_2_0_1"/>
    <dbReference type="OMA" id="PNSMDFS"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09904">
        <property type="entry name" value="H3TH_XPG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000025">
        <property type="entry name" value="DNA repair protein RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000057">
        <property type="entry name" value="RAD2p Single-stranded DNA endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000046">
        <property type="entry name" value="RAD2p Single-stranded DNA endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="15">
        <location>
            <begin position="738"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="336"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="465"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="515"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="605"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="659"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="537"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="605"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ45140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="990" mass="114988" checksum="9878A9D97F3F0DED" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHN4</accession>
    <name>C4YHN4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Erv29p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_03582</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHN4"/>
    <dbReference type="PaxDb" id="5476-C4YHN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03582"/>
    <dbReference type="HOGENOM" id="CLU_056195_0_0_1"/>
    <dbReference type="OMA" id="RHRHFPW"/>
    <dbReference type="OrthoDB" id="7859621at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002995">
        <property type="entry name" value="Surf4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02077">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01339">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ45266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="35073" checksum="D974C1EB14B5A9C3" modified="2010-10-05" version="1">MSYRGPNQFGNQPPHHGIPSQPQPHIGPISSSKSPLEQFEDVAKKVEDWIDDYFKVLKPYVPAIGRAFLVATFYEDTLRIFTQWNEQVYYLHNYRHYWRWLTVLFLINNMVVMTVASTLVIARKKNNIATIALIVVVIIQGIGYGLLFDAQFVLRNLSVVGGLVLAFSDSIVRDKRSLNMPGLPMLNNQDNKKYFLLAGRILLVLLFLGFVFSSDWSLGRVFIIIIGLTSCASIVVGYKTKFSAAIMLIVLFLYNVFTNQFWAYASQDARRDFLRYEFFQVLSIVGGLLLVVNAGAGEFSIDEKKKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHX9</accession>
    <name>C4YHX9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Midasin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">MIDAS-containing protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_03683</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the midasin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YHX9"/>
    <dbReference type="HOGENOM" id="CLU_000050_1_0_1"/>
    <dbReference type="OMA" id="KRCAIAP"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000142">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000582">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000712">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001368">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048617">
        <property type="entry name" value="MDN1_AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21108">
        <property type="entry name" value="MDN1_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="315"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="653"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="1088"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="1374"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="1758"/>
            <end position="1926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ45361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="2193" mass="248561" checksum="D1B23FDC225CAB98" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI32</accession>
    <name>C4YI32_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_03740</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI32"/>
    <dbReference type="PaxDb" id="5476-C4YI32"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03740"/>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_1"/>
    <dbReference type="OMA" id="CAGSDVM"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019740">
        <property type="term" value="P:nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="29"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ45414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="480" mass="51926" checksum="25E7974CB5A3FC53" modified="2009-07-28" version="1">MSGNFTGTGTGGDVFKVDLNEQFDRADMVWIGTASVLVWIMIPGVGLLYSGISRKKHALSLMWAALMAACVAAFQWFWWGYSLVFAHNGSVFLGTLQNFCLKDVLGAPSIVKTVPDILFCLYQGMFAAVTAILMAGAGCERARLGPMMVFLFIWLTVVYCPIAYWTWGGNGWLVSLGALDFAGGGPVHENSGFAALAYSLWLGKRHDPVAKGKVPKYKPHSVSSIVMGTIFLWFGWYGFNGGSTGNSSMRSWYACVNTNLAAATGGLTWMLVDWFRTGGKWSTVGLCMGAIAGLVGITPAAGYVPVYTSVIFGIVPAIICNFAVDLKDLLQIDDGMDVWALHGVGGFVGNFMTGLFAADYVAMIDGTEIDGGWMNHHWKQLGYQLAGSCAVAAWSFTVTSIILLAMDRIPFLRIRLHEDEEMLGTDLAQIGEYAYYADDDPETNPYVLEPIRSTTISQPLPHIDAVADGSSNNDSGEAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI48</accession>
    <name>C4YI48_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit beta</fullName>
            <ecNumber evidence="13">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_03756</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="13"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI48"/>
    <dbReference type="PaxDb" id="5476-C4YI48"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03756"/>
    <dbReference type="HOGENOM" id="CLU_022398_0_2_1"/>
    <dbReference type="OMA" id="SMEEGGW"/>
    <dbReference type="OrthoDB" id="14523at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="86"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ45430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="415" mass="44481" checksum="B1F1DA86E68BBAE7" modified="2009-07-28" version="1">MDGTEGLVRGTEVNDTGAPISVPVGRGTLGRIINVVGEPIDDRGPIECKEKKPIHAEPPSFVEQSTAAEILETGIKVVDLLAPYARGGKIGLFGGAGVGKTVFIQELINNIAKAHGGFSVFTGVGERTREGNDLYREMKETGVINLEGDSKVALVFGQMNEPPGARARVALTGLTIAEYFRDEEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGLLQERITTTKKGSVTSVQAVYVPADDLTDPAPATTFAHLDATTVLSRGISELGIYPAVDPLDSKSRLLDASVVGQEHYDVATGVQQTLQAYKSLQDIIAILGMDELSEADKLTVERARKIQRFLSQPFAVAEVFTGIPGRLVRLQDTVKSFKDVLEGKYDNLPENAFYMVGGIEDVVAKAEKLAAESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI60</accession>
    <name>C4YI60_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_03769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI60"/>
    <dbReference type="PaxDb" id="5476-C4YI60"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03769"/>
    <dbReference type="HOGENOM" id="CLU_1069557_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ45442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="260" mass="29347" checksum="8289445827D6D708" modified="2009-07-28" version="1">MTQSIFFSSTSDKFFFFCFSFSFNASYHQPDMIFPILPVISSPEDKQSIDEFSLVGQVLFPIESVSPKKHFIHQFPHDLDIFVNAIDNATTDQIVELLNVGIKQVFVNEKQYHDAIEAGLPSSRFVVAVDVPSTELLTSEASFVTSKPFSESDLKKYNANENRVIYIESNFTQDGAIELAKNYVPVIPSTKLTVKREEENKISISAVFVSTLTTDRPDGVVHYINHNPFTFLYSFGYSIFVPRDSIIAAIEEKSWGLPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI72</accession>
    <name>C4YI72_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA damage checkpoint control protein RAD17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_03781</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the rad1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI72"/>
    <dbReference type="PaxDb" id="5476-C4YI72"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03781"/>
    <dbReference type="HOGENOM" id="CLU_038605_0_0_1"/>
    <dbReference type="OMA" id="VHLEHIT"/>
    <dbReference type="OrthoDB" id="337581at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016587">
        <property type="entry name" value="Rad17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003021">
        <property type="entry name" value="Rad1_Rec1_Rad17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02144">
        <property type="entry name" value="Rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011769">
        <property type="entry name" value="Cell_cycle_RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01245">
        <property type="entry name" value="RAD1REC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR011769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ45454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="336" mass="38086" checksum="254286B60254023D" modified="2009-07-28" version="1">MLFVESDSESVNNTDICQVEDSFTASTTQIAHLSDIFQSLVSINNQAIIRIKETGITIYSSYNHTFNVNVNIDPSLFSIYSITGEEFTLGVDLSLIGECFTSVASTLKFEKSVTCYLNYQGEGSPLVIEFEDTYILEKLEFYTYIIESGMEDDNLGIDYERVEMEAMVRSDVLTNILSDLWQIDTENLFIYAEADTLTFISNGPIGTSKLIFPNDKDVLEKLEISGDKRYVVSQFSYETFYRIFRAVRLSSKCKLIKDAHGCFSIQLLCKKLPLSGYSGTLVTINMMELNHDEFMIGWIEEQEKPVLFTSFKKVEVQSSVVDKRNVNGAVEVPLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI89</accession>
    <name>C4YI89_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_04161</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI89"/>
    <dbReference type="SMR" id="C4YI89"/>
    <dbReference type="PaxDb" id="5476-C4YI89"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04161"/>
    <dbReference type="HOGENOM" id="CLU_108696_0_2_1"/>
    <dbReference type="OMA" id="FMSSHDD"/>
    <dbReference type="OrthoDB" id="448946at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099128">
        <property type="term" value="C:mitochondrial [2Fe-2S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000003">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="15">
        <location>
            <begin position="33"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEQ45824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="110" mass="12322" checksum="68C7F5D031250BF0" modified="2010-10-05" version="1">MFKLAFRSIRAPVARASFVKPIRFYVAPPISKDEVTSRAIQALKTVAPLQESNITLESSFQKDLGLDSLDTVEALVALEEEFDLEIPDKISDEIKTVGEAVDYIYKEESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIB1</accession>
    <name>C4YIB1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_04183</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIB1"/>
    <dbReference type="SMR" id="C4YIB1"/>
    <dbReference type="PaxDb" id="5476-C4YIB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04183"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OMA" id="SIDITHC"/>
    <dbReference type="OrthoDB" id="413582at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001403">
        <property type="entry name" value="Cyclin-dependent protein kinase-activating kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="7"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ45846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="339" mass="39920" checksum="523BF46CA6105ACB" modified="2009-07-28" version="1">MKLSDYYIDKELIYNSAISDIYTAIDKFNNLPVCLKIVDEDFSLPPHSIHREVLILKTLKPHPNIIEYFNDLKICDDIILVTKLYRYDLSQLIEITKYCKRTTRFIYGINGNLVSNQYTLANEIEEKDIKLWLKSMSSGLEFIHSQGIIHRDIKPSNIFFARDDITQPIIGDFDICYDLKSPPKDEPPMAKYIDVSTGIYKAPELILGITNYEYEIDIWSLGIILTGLYSENFQSVLVKDDKELTNDSHVSDLYLLNQIFENFGTPNLTDFEDELFCDEYNNENLHFKKFNLQKYPRKDWDIILPRCNDDFMKEIFTKMIRYDRSKRITSKEILQLMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YII8</accession>
    <name>C4YII8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alkylphosphocholine resistance protein LEM3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_04263</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YII8"/>
    <dbReference type="PaxDb" id="5476-C4YII8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04263"/>
    <dbReference type="HOGENOM" id="CLU_025025_0_1_1"/>
    <dbReference type="OMA" id="WWTDTNV"/>
    <dbReference type="OrthoDB" id="340608at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF20">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE ACCESSORY SUBUNIT LEM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ45923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="50112" checksum="B71CEC516521153E" modified="2009-07-28" version="1">MSRTANDAQQIDNGDQQREGVLDEYAQEGEYESSSDYDDESFVEKKEKSRRPKENSFTQQRLKAINPVLTAKTVIPLLVAIAIVFVPLGAAMWYASHKIEDITIDYSQCQNLASFDYWSEIPDNFTTYNFRNIDTNSESKPKFSWKLTNDTSQQFDDEKLVCQVQFEVVEKMKGPIYLYYRLHNFYANHRRYVKSFSEDQLNGKPATLNTIKNTVGQNCQPLSDVNGKRIYPCGLIANSLFNDTFTEAFEAVNGTSSDNTLVLTDKGIAWSTDKNRFKKTQYNYTEVVPPPNWYKKFPNGYNETNIPDISTWYQFQNWMRPSALATFNKLALRNDTGSLERGIYQINVGLHFPVLPYKGKKYLYITQRSVIGGKNDFLGISWMVGGGVCFILGLALLVINFVKPRKTGDVNLLSWNQEKTKRDEQSAAAAEGVTTGFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIQ8</accession>
    <name>C4YIQ8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_04334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIQ8"/>
    <dbReference type="SMR" id="C4YIQ8"/>
    <dbReference type="PaxDb" id="5476-C4YIQ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04334"/>
    <dbReference type="HOGENOM" id="CLU_067847_0_0_1"/>
    <dbReference type="OMA" id="NTQMATH"/>
    <dbReference type="OrthoDB" id="2535391at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042123">
        <property type="entry name" value="Zip3/RNF212-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663:SF17">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="124"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ45993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="41789" checksum="DA9077D350AAD3FC" modified="2009-07-28" version="1">MNQEFDQNSPYIYCGICFKDNHDVEGLDNKLLLTSCAHITCDIHLQSKHIESYLAQNDSDSPCPVCGSNPISTVPINRMLPVELKNFFIPTPQQIDLLTSSGKFQYCSLVDRINYYRSTISKMNEKLKKQKEFLYAAKEEITQLSKYKLQVQELTNEIDLLRKQLQSTARPDTFDLSNDNENEKSGEFENNIFTRESSPTQTASHTFINKVHRESLQKVIPTSKPDTDDRNGSTRRRSFFAESTKLGEINSRSISSSNESSNSLNSLKRFSFESPKKKYLQNPIGKRSATSQLATRITANMKLGVPVSASNASSRSYQNGYVNKVSKDPTLTRTMRRASEASPYFKGLNYKYKNSSHDHHQHQYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIS5</accession>
    <name>C4YIS5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ46010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIS5"/>
    <dbReference type="PaxDb" id="5476-C4YIS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04352"/>
    <dbReference type="HOGENOM" id="CLU_298626_0_0_1"/>
    <dbReference type="OMA" id="IMFLPHI"/>
    <dbReference type="OrthoDB" id="6022054at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007483">
        <property type="entry name" value="Hamartin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154:SF2">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04388">
        <property type="entry name" value="Hamartin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="928"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="723"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="856"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="956"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="983"/>
            <end position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1042" mass="119818" checksum="FC72ACA12D3545A8" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIV2</accession>
    <name>C4YIV2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ46037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIV2"/>
    <dbReference type="PaxDb" id="5476-C4YIV2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04381"/>
    <dbReference type="HOGENOM" id="CLU_055232_2_1_1"/>
    <dbReference type="OMA" id="EVKQYLY"/>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="1">
        <location>
            <begin position="26"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="194" mass="22319" checksum="39902AB8BCE33B7D" modified="2010-10-05" version="1">MPIPPTSTENKNLDEDISSSRLSRYNAIQPEVKQYLYDILSPKYPDLFNHKFSIDNTTSSSSFPAGKFLQDIDLCDLLKDGELLCKLGQLLGRNNNIIPNNPTFKFKNSQMAFHQMENISFFLKLCELIKLPHDEIFQTVDLFDGKDPYQICITLMSFSRIVHDLDNQVFYKVIGPKIVKVKPTVPIKPYKLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIW0</accession>
    <name>C4YIW0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide:N-glycanase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04389</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglutaminase-like superfamily. PNGase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ46045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIW0"/>
    <dbReference type="SMR" id="C4YIW0"/>
    <dbReference type="PaxDb" id="5476-C4YIW0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04389"/>
    <dbReference type="HOGENOM" id="CLU_031058_0_1_1"/>
    <dbReference type="OMA" id="AWDKPRL"/>
    <dbReference type="OrthoDB" id="409136at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF19">
        <property type="entry name" value="PEPTIDE-N(4)-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="6">
        <location>
            <begin position="190"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="363"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ46045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="395" mass="45840" checksum="2A29707D9AE9F264" modified="2009-07-28" version="1">MTPPIKSPSSSSVDYGKLSEQLMIAYTKDVLQRNLQKFHGEQHRQQFKQLLNQPVIKSIHSLSGIIVRYRHNNSELDKALDTIDLPKIFERLEIREKTNKDKNLDYDDLLVLELLNYFKNDFFKWVNSPDCPSCGSNEDVQGLGAINPSSSKTISQSQAIIDQVSVIEVHECKKCKQKIEFPRINNPVTLLTTRRGRCGEWVNCFMLILQALIGGGDDDSDRIRYVWNQEDHVWCEYYSLSSKRWIHLDPCEGVYDEPLLYCNNWGKRMSYVIGFNYNYMIDLSDKYIVPEKQIPKNSIVNVQNVNFVISYSNGINQLKHFKRIEQQQQQQEVDVNEQRNLAFLKLYHNFLVPYNKEINQLKPELTKTTPSTDLPSGRQSGSTEWTKSRGENGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ42</accession>
    <name>C4YJ42_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_03854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ42"/>
    <dbReference type="PaxDb" id="5476-C4YJ42"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03854"/>
    <dbReference type="HOGENOM" id="CLU_079688_0_0_1"/>
    <dbReference type="OMA" id="THWEIVS"/>
    <dbReference type="OrthoDB" id="4023429at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ45526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="284" mass="32399" checksum="896CA32D49042B19" modified="2009-07-28" version="1">MELSNYTHWEIVSYVQVFLFAILLVAFLVITSIKKKERKGLRQILPFFIFFTIFLVLKIVGGILGLVFIHQKTFNVSLFIPTFIFDSIGLGFIARSITSLVTHNFKYQDDLPEFFRSKHQKAKNNNSSNAYKKSDNDSDNYNDDNDEINYWPFRVLTIILIAAIVVNIVGTNISVNNQGSSMGTSLIKVGSILFLIEILLMILFLVTIGLSGSQLNTVVYLLIVGLVVLIVRCVFSILSGFHWSTWENPSPYIIYFGKYQYYTFLALLPEVITAIIILVAFLFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJA1</accession>
    <name>C4YJA1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_03914</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJA1"/>
    <dbReference type="PaxDb" id="5476-C4YJA1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03914"/>
    <dbReference type="HOGENOM" id="CLU_020695_11_0_1"/>
    <dbReference type="OMA" id="DYKFIGM"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="243"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="336"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="340"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ45585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="492" mass="56780" checksum="0FEA1D3A2584D891" modified="2009-07-28" version="1">MPQVTKTNNENEFRLTRSKVQHQESISTIKNTTISNSQHKQQTQQQISSPPQVSVTSSEGVSHVNTRQYLGDVSNQYITNAKPTNKRKPLGGDNAPLQKQHHRPSRPIPIASDNNNNGSTSSSSNSSNNNNNDANRLASLAVPSRLPQKRQATESSTNLVEKLRVPQPEAGERSQSYHKKSRLIDYEWQDLDEEDSDDQLMVSEYVNEIFSYYYELETRMLPDPQYLFKQTLLKPRMRSILVDWLVEMHLKFKLLPESLFLAVNVMDRFMSVEVVQIDKLQLLATAALFTAAKYEEVFSPSVKNYAYFTDGSYTPEEVVQAEKYMLTILNFDLNYPNPMNFLRRISKADDYDVQSRTLGKYLLEITIVDYKFIGMRPSLCCASAMYLARLILGKLPVWNGNLIHYSGGYRISDMRECIELMFQYLIAPIEHDEFFKKYAMRKFMRASTLCRNWAKKFQASGRDLFDERLSTHRLTLEDDDEEEEIVVAEAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJE6</accession>
    <name>C4YJE6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-tRNA hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_03959</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenine + H2O + H(+) = hypoxanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23688"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="7"/>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK03"/>
    <dbReference type="PaxDb" id="5476-C4YK03"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05795"/>
    <dbReference type="HOGENOM" id="CLU_039228_7_0_1"/>
    <dbReference type="OMA" id="NHFTIHA"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043103">
        <property type="term" value="P:hypoxanthine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009168">
        <property type="term" value="P:purine ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01320">
        <property type="entry name" value="ADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000039">
        <property type="entry name" value="Adenine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01962">
        <property type="entry name" value="Adenine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028892">
        <property type="entry name" value="ADE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114:SF6">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="8">
        <location>
            <begin position="9"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ47232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="347" mass="39733" checksum="090B49FD16DF0118" modified="2009-07-28" version="1">MENFLRELPKCEHHVHLEGTLEPSLLFKLAKRNNITLPETFPKTVEECNDRYNRFTDLQDFLDHYYIGMGVLITENDFYDLAMDYFTKAHSDGCLHSEVFFDPQGHVERNIDIDVVVQGFNRACKDANTKYGTTNKLIMCLLRHLPAENGLQTIHSASKYYQDGIIHGLGLDSSEKPFPPNLFTECYAHIKDNFPEVGLTAHAGEEGDHTFVSDALNLLKVSRIDHGVNSHQSEELMQRLAEQKTLLSLCPLSNVKLQVVKDVKELPIDKFFQMNVPFSINSDDPAYFGGYILDNYKAVHTRFGFTKDQWKIIALNGIKGSWCDDQRKNELISLVEEVYKKYNIEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK96</accession>
    <name>C4YK96_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Proteasome activator BLM10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_05893</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YK96"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05893"/>
    <dbReference type="HOGENOM" id="CLU_000772_0_0_1"/>
    <dbReference type="OMA" id="ECTQLVP"/>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032372">
        <property type="entry name" value="Blm10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055455">
        <property type="entry name" value="HEAT_PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16547">
        <property type="entry name" value="BLM10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23096">
        <property type="entry name" value="HEAT_PSME4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome activator Blm10 N-terminal" evidence="12">
        <location>
            <begin position="75"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="11">
        <location>
            <begin position="511"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4-like HEAT repeat-like" evidence="13">
        <location>
            <begin position="1634"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="10">
        <location>
            <begin position="2112"/>
            <end position="2200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="182"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1109"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="187"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1115"/>
            <end position="1137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ47325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2200" mass="252477" checksum="8D57156542D7676C" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKA7</accession>
    <name>C4YKA7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="6">D-arabinose dehydrogenase heavy chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_05904</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKA7"/>
    <dbReference type="SMR" id="C4YKA7"/>
    <dbReference type="PaxDb" id="5476-C4YKA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05904"/>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="OMA" id="TAWYYGT"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000031">
        <property type="entry name" value="D-arabinose dehydrogenase heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ47336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="326" mass="37367" checksum="C0A1E49487B67EE3" modified="2009-07-28" version="1">MKLATEIDFKLNNGKTIPALGLGTVASKDPKDVKDQVITAVKAGYRHIDTAWFYGTEKYIGEALQELFAEGIIKREDLFITTKFWPSYWANPEKSLDESLKDLQLDYVDLFLQHWPICLHGDENGLPKIPKDENGELIYDDDPTPNGTKYIDVYHKLEDILETTTKVRSIGVSNYSIPKLRQLLPKVKKHIPVCNQIEYHPQLPQQDLVDYCTKNNILISCYSPVGSYGAPVLKIPLVKQLAEKYQVTENEIADAYNILNGRVTLPRSSNLERIKTIIRLPDLTKEELDELYQVGVKDPQRYICDPWGYGIGFRWWKGDTLSKEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKP7</accession>
    <name>C4YKP7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_06053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKP7"/>
    <dbReference type="PaxDb" id="5476-C4YKP7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06053"/>
    <dbReference type="HOGENOM" id="CLU_990446_0_0_1"/>
    <dbReference type="OMA" id="ADSEDIY"/>
    <dbReference type="OrthoDB" id="4093337at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946576" evidence="1">
        <location>
            <begin position="19"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="287" mass="30921" checksum="3CFB6F007F83AFE8" modified="2010-10-05" version="1">MKLLYTYLSFLLIAFTFAQTLDVNPITDELSIRDTSGATSEEIEVANYLQQLVVAAGLDSQNLTKRDYPDNSLLTAAFTSLNRSGVGVQLVHTFATSSATQGTTINTVGQYVSVTGLTKLLTSANKSGLAVSIVMRFFINYSLVPGLWNVIVALWNNGVISLGKRGLLDLVGGIINGVQQSIINSLITIINSVTDLTQICSSLNKSGLAVSIVDDLLTTSDGQNFVVKLATNLVQKGIVTFDKLLSSLQSSGIIVDTFTTIIGNSTYRKIIFIWAVKSLVGFIKYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKZ8</accession>
    <name>C4YKZ8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cobalamin-independent methionine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine synthase, vitamin-B12 independent isozyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_01512</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKZ8"/>
    <dbReference type="SMR" id="C4YKZ8"/>
    <dbReference type="PaxDb" id="5476-C4YKZ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01512"/>
    <dbReference type="HOGENOM" id="CLU_013175_0_0_1"/>
    <dbReference type="OMA" id="KVMKGML"/>
    <dbReference type="OrthoDB" id="1053771at2759"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03312">
        <property type="entry name" value="CIMS_N_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000003">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003556">
        <property type="entry name" value="PRK05222.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <position position="657"/>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
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<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
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                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
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                <person name="Logue M.E."/>
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                <person name="Neiman A.M."/>
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                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLI9"/>
    <dbReference type="PaxDb" id="5476-C4YLI9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01707"/>
    <dbReference type="HOGENOM" id="CLU_047849_0_1_1"/>
    <dbReference type="OMA" id="NHELRYT"/>
    <dbReference type="OrthoDB" id="2119945at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013897">
        <property type="entry name" value="Duc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826:SF2">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08588">
        <property type="entry name" value="Duc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function at the cortex 1" evidence="1">
        <location>
            <begin position="19"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="300" mass="34475" checksum="A226F9AC44F6A35E" modified="2009-07-28" version="1">MSAFFKLFTIPINMPIIKRLYITASNNYDSNYQIVPVNTEQPLEIDSKIGLFKLFLNIKNFDGSKPHLSNSLYNLQDDVYLNGEKIEFNKPPKDDDEPNLRINIEFTPKEDINGSNFAFGNDFTYPIRDYVPVGLLNTGLKLFNWFINDSVKGDPYPDKPYLYGPGISSFTYMAIKNPDDPTVNTHSKKAVENLFQQEENIPKEPNARKKFFGNKKKCEKFTFKKGVTYILQFDTNFVKLADSKYSISIPRFDFDVSHYANDTLNNVNWVFKEGGYEGVDFGKLGLIINFKVLSEDSEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLK3</accession>
    <name>C4YLK3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_01721</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLK3"/>
    <dbReference type="SMR" id="C4YLK3"/>
    <dbReference type="PaxDb" id="5476-C4YLK3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01721"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="OMA" id="WATYLFY"/>
    <dbReference type="OrthoDB" id="648285at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000119">
        <property type="entry name" value="MFS monosaccharide transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF73">
        <property type="entry name" value="METABOLITE TRANSPORT PROTEIN YDL199C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="29"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ43484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="647" mass="71348" checksum="EE0AED6652EA3E14" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLQ6</accession>
    <name>C4YLQ6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLQ6"/>
    <dbReference type="PaxDb" id="5476-C4YLQ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01775"/>
    <dbReference type="HOGENOM" id="CLU_019359_0_0_1"/>
    <dbReference type="OMA" id="ESTRMKW"/>
    <dbReference type="OrthoDB" id="4026687at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="700"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="795" mass="85793" checksum="383ED0BE9734F4BB" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM10</accession>
    <name>C4YM10_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_01885</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM10"/>
    <dbReference type="PaxDb" id="5476-C4YM10"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01885"/>
    <dbReference type="HOGENOM" id="CLU_113391_1_0_1"/>
    <dbReference type="OMA" id="TFIRFAT"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF2">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="7">
        <location>
            <begin position="64"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="191" mass="21738" checksum="E7F0BDED72AAA148" modified="2010-10-05" version="1">MTNLRELEEEIETYEGTSGDLQEQNVLQLRQRKLSYTRRPTSQPKVQSKFPYSLVMKVETSEPRDVLQSERTCLTFVRFSTALFFTALGIILNFKLDTSGSPDDNSGNNKKKYFNHTAFNSAISYILLVLALFVLCVTGVNYFVTINRYAKHKIATYSFNNLTTIIGMTSIIVTLMAINITMIVEGYIEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMI5</accession>
    <name>C4YMI5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Chorismate synthase</fullName>
            <ecNumber evidence="4 8">4.2.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_02067</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the chorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMI5"/>
    <dbReference type="PaxDb" id="5476-C4YMI5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02067"/>
    <dbReference type="HOGENOM" id="CLU_034547_0_1_1"/>
    <dbReference type="OMA" id="MLSINAV"/>
    <dbReference type="OrthoDB" id="1721239at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.150.10:FF:000004">
        <property type="entry name" value="Chorismate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="entry name" value="Chorismate synthase AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003793">
        <property type="entry name" value="PRK05382.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085:SF0">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="Chorismate synthase, AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ43816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="378" mass="40944" checksum="6C25FB78884CDAC1" modified="2009-07-28" version="1">MSSFGTLFKVTTYGESHCKSVGCIVDGCPPGMSLTEADIQPQLTRRRPGQSKLSTPRDEKDLVEIQSGTENGLTLGSPIGMIVRNKDHRPGDYSETDLYPRPSHADWTYIQKYGTKSSSGGGRSSARETIGRVAAGAIAEKILAKVNNVEIVAFVSAIGEISMNKSPQDAKFQELLYTITREQVDGVGPIRCPDANVREEMVKVIEKYRDAKDSIGGVVTCVIRNCPIGLGEPCFDKLEAKLAHAMLSLPATKGFEFGSGFEGIKIPGSKHNDAFYYDENFGRLRTETNNSGGIQGGISNGENIYFSVAFKSAATISQEQETATYDGKSGVLAARGRHDPSVTPRAVPIVEAMTALVLCDEYMIQQARTSTRLLVQDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMM8</accession>
    <name>C4YMM8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_02111</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
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</entry>
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                <person name="Forche A."/>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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                <person name="Forche A."/>
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                <person name="de Groot P.W."/>
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                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
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            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
            <orientation evidence="1 7">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the OS-9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN26"/>
    <dbReference type="PaxDb" id="5476-C4YN26"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02266"/>
    <dbReference type="HOGENOM" id="CLU_1077675_0_0_1"/>
    <dbReference type="OMA" id="HANYWTI"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0430">Lectin</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946648" description="Endoplasmic reticulum lectin" evidence="8">
        <location>
            <begin position="19"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="9">
        <location>
            <begin position="114"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ44007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="258" mass="29417" checksum="4DF1DAC66105C56A" modified="2009-07-28" version="1">MNWTSLVYLWFIFKSIFADLTSHQLKSKVVFLDTTISDEVARSYLGSEDGNVTHGNYEILSIANGANDGNITSYLCQLPRTKKMAPTKPKPTMSVHELKSRAIDLISESFVEGTSCVFSFNLHANYWTIGYCHGINVIQFHENLDDFISGIHKPHSPNHVYTLGNFSKQTSPLEFEFDTKERTISQRLLGEVCDLTGEPRTIDTIYRCDHILEISELTEIRTCQYELHINVPKLCSLPEFKRTNLEEGVSEILCTRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN32</accession>
    <name>C4YN32_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_02272</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN32"/>
    <dbReference type="PaxDb" id="5476-C4YN32"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02272"/>
    <dbReference type="HOGENOM" id="CLU_007818_7_0_1"/>
    <dbReference type="OMA" id="WDFGIWD"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000125">
        <property type="entry name" value="CTS1p Endochitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944336" description="chitinase" evidence="14">
        <location>
            <begin position="17"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="15">
        <location>
            <begin position="23"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="313"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="319"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEQ44013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="567" mass="60035" checksum="1E84313E555411D0" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNB4</accession>
    <name>C4YNB4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="PaxDb" id="5476-C4YNB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01370"/>
    <dbReference type="HOGENOM" id="CLU_025711_1_2_1"/>
    <dbReference type="OMA" id="YFKNEVG"/>
    <dbReference type="OrthoDB" id="10254604at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF50">
        <property type="entry name" value="UPF0659 PROTEIN YMR090W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="229" mass="25155" checksum="7F124CA9FA9632F9" modified="2009-07-28" version="1">MSTVKNIIVFGSHGKIGQQFVRLLADKTSVFRGTAVVRNDEQATTIKSITANSPNVSSLNFTLDNASVGEIASAIKGHDAVVFTVGSAGKNLLQVDLDAAVKTFEASVEAQVRRFIIISALHADNREFFSKLGLRNYYIAKHYADRILVDEFSDKLDYTVLKPTSLSDDAATGKIRIIKSRDEEIGTITRADVAKVIYEIVNDKDTFGKSYNIANGDLDITDKRIYKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNH0</accession>
    <name>C4YNH0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_01430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNH0"/>
    <dbReference type="PaxDb" id="5476-C4YNH0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01430"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_1"/>
    <dbReference type="OMA" id="NRFANNC"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
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    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ43204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="24593" checksum="28EBA1466CFCC7C1" modified="2009-07-28" version="1">MFKGKTALVTGGSRGIGLAISKKLAIEGAAVSLLARNETILQQSLSELATDHGQTHTYHSLDLTSLLLRNPQDLNFGSPTILVNCAGVTNHSLLLRMTQEEIVNTINLNLTVPILLSQMVVKNMLRQKGSDPTILNISSVLSMTEHFIPGTSVYAASKAGLLGFTKSLSKELRGKIRINALMPGLVKETDMGNKVMADINSVSVESVANEAIRILQDTKLNGECIALDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNQ7</accession>
    <name>C4YNQ7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNQ7"/>
    <dbReference type="PaxDb" id="5476-C4YNQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02839"/>
    <dbReference type="HOGENOM" id="CLU_522726_0_0_1"/>
    <dbReference type="OMA" id="MAINTHQ"/>
    <dbReference type="OrthoDB" id="4088353at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="591" mass="67146" checksum="1F88EA298037EDCF" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP03</accession>
    <name>C4YP03_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_02938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YP03"/>
    <dbReference type="PaxDb" id="5476-C4YP03"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02938"/>
    <dbReference type="HOGENOM" id="CLU_1165700_0_0_1"/>
    <dbReference type="OMA" id="TRDITEC"/>
    <dbReference type="OrthoDB" id="4085867at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014841">
        <property type="entry name" value="Rad33"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08730">
        <property type="entry name" value="Rad33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ44662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="234" mass="26874" checksum="D6FE795D75BD97EA" modified="2010-10-05" version="1">MPPKRNQKSKLSLSKTFEQVDEEIEDEIFETYSELLGDEVENQDVTLSQLPQILSDLRIPKCFTKDIEKCIDYYYDFIKDKDVHLDPLNTRQQNTLAMIHSYTVTAGIKQLDEIIDILDVEKLLYNLNRLIKFRNNYSHIRKSWQLFVSTAADSSASETYKLTFPDLKKIKTSLNLDSDPSTKAPLNDTFLIDMLGCCSHDSNGNLLNFDFEKQGACVNIKDFAEILGQIGELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP51</accession>
    <name>C4YP51_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_02989</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YP51"/>
    <dbReference type="SMR" id="C4YP51"/>
    <dbReference type="PaxDb" id="5476-C4YP51"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02989"/>
    <dbReference type="HOGENOM" id="CLU_826382_0_0_1"/>
    <dbReference type="OMA" id="YKIATRT"/>
    <dbReference type="OrthoDB" id="340227at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="299"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ44710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="397" mass="44840" checksum="4A2002B3B625ABDD" modified="2010-10-05" version="1">MSTFKRLLPAPPPSKNAWGVNQSIDGNDPSTITQHNDNRTNLSSRNSKEQKWKNNSYYRNIQFTNLTDKPPNLTEDIEMISNNMKFISFSQSPILPPTRDTGTTSVPFPTSISDYNYKLANMANTNDNHKYTHSGKYENVTEEDDREILISVGKNTKIKKPKFPKSTKIKGGTGWYKYRISGDSPKEIPAYTTNAINTYPIPFEILPFEAQPFDIIPSPHDSITTSIGSASSFPNSAPPMVFYPQFGIPVYQIPIFNEGHPSSSLPISPISPSLQSQQSHSSPIFPPPPSSSSQLQQLSSAITVKKENIKHQIEYYFSTENLCKDTYLRSLFNKSDGSIQLSQLLSFNRMRMLTNNGKYTNLVLESIEEIPILELLLDENDKNNDSVRLVNWKSWII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP76</accession>
    <name>C4YP76_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein HRI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_03020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HRI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YP76"/>
    <dbReference type="PaxDb" id="5476-C4YP76"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03020"/>
    <dbReference type="HOGENOM" id="CLU_076653_0_0_1"/>
    <dbReference type="OMA" id="YIEIWRS"/>
    <dbReference type="OrthoDB" id="4045395at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd11693">
        <property type="entry name" value="HRI1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11692">
        <property type="entry name" value="HRI1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.310">
        <property type="entry name" value="Protein HRI1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.320">
        <property type="entry name" value="Protein HRI1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031818">
        <property type="entry name" value="Hri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038744">
        <property type="entry name" value="Hri1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043047">
        <property type="entry name" value="Hri1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16815">
        <property type="entry name" value="HRI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ44735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="245" mass="28162" checksum="35C189B70829479E" modified="2009-07-28" version="1">MVLSTRVSIQWPPKEAEEKTSTLALTTPANNYDDIRIFKTQYPCLNSTLPLPFTQVFELGLAGKEIPLDNDKIKFDNYISTLALQQSIESGLPIFSIDVDIGHFSNYGLDGDRKETGEMKNSEGIIAPYIEIWRSLDPLKHTPQTEVRENTENEPMKTKIKMNVFTLKLMDHLGVLIRIGNWIQGIIQEGNSIHVIRSWYNENLQQWCNLIEYGNSDAFPIQFNGDIDDVVKVRNGWKWKCIERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP91</accession>
    <name>C4YP91_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_03039</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YP91"/>
    <dbReference type="PaxDb" id="5476-C4YP91"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03039"/>
    <dbReference type="HOGENOM" id="CLU_008695_0_0_1"/>
    <dbReference type="OMA" id="YELKWAG"/>
    <dbReference type="OrthoDB" id="4070583at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060962">
        <property type="term" value="P:regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045178">
        <property type="entry name" value="Fhl1/FHA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21712">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN FHL1"/>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPJ0"/>
    <dbReference type="SMR" id="C4YPJ0"/>
    <dbReference type="PaxDb" id="5476-C4YPJ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02391"/>
    <dbReference type="HOGENOM" id="CLU_033999_0_0_1"/>
    <dbReference type="OMA" id="EDHNAYI"/>
    <dbReference type="OrthoDB" id="10249065at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001074">
        <property type="entry name" value="Probable SOF1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001105">
        <property type="entry name" value="WD40-repeat-containing domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="63"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="301"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="344"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="8">
        <location>
            <begin position="378"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ44129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="436" mass="49421" checksum="F84386986A36F0D1" modified="2010-10-05" version="1">MKVKTISRSSDTYIPVKNTQESALPRNLNPALHPFERAREYTRALQATKLERMFAQPFIGQLGDGHRDGVYFIAKNYQATNQIASGSGDGIIKYWNLTDRLETASFKAHYGMVSGICIYANKMYSCGDDKTIKIWSVNSDDFDIKVNDDVDGIYRNQLGGAGGGDGKTSGGLLKTFIGEHSFKGIDHHRDDDLFVTGGATIQLWDVNRSKHISDLSWGADNVGTVKFNQTETNIIASSGSDNSIVLYDIRTNTPVHKVVTSLRNNCITWNPMEAFNFATGNEDHNGYLYDMRNLQKTLKVYKGHVGAIMDVDFAPTGQELVTGSYDKTIRLWKTLDGRSKDVYHTKRMQKVFSVKYSTDSKYIISGSDDTNLRVWRSDASSRSNIKSSRQRAKLEYQDKLKERYKYMPEINRIARHRHLPKPVKKAQDMKRLYSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPJ8</accession>
    <name>C4YPJ8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RAVE complex protein Rav1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPJ8"/>
    <dbReference type="PaxDb" id="5476-C4YPJ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02399"/>
    <dbReference type="HOGENOM" id="CLU_000310_0_0_1"/>
    <dbReference type="OMA" id="NSHLTLW"/>
    <dbReference type="OrthoDB" id="342131at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="1">
        <location>
            <begin position="669"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1235" mass="141355" checksum="475A9BF0C414C103" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPJ9</accession>
    <name>C4YPJ9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutamate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_02400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPJ9"/>
    <dbReference type="SMR" id="C4YPJ9"/>
    <dbReference type="PaxDb" id="5476-C4YPJ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02400"/>
    <dbReference type="HOGENOM" id="CLU_011856_0_0_1"/>
    <dbReference type="OMA" id="RHATYHA"/>
    <dbReference type="OrthoDB" id="2161780at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677:SF8">
        <property type="entry name" value="CYSTEINE SULFINIC ACID DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ44138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="55602" checksum="6C9F69C924B32686" modified="2010-10-05" version="1">MTIESNLESNRSEELDNLLTQLKPRLLAYIDEADPKSSNYKPESLGTFHEPKFLKQQFIDPDNDLDKPCSEEELFETIDKVLKFSVNTWNPGFLDKLYASNNPIGVISDILLSILNTNSHVYTVSPVLSVLENYIGKKYAQLFFHNETCGGLTFSGGSWSNITSLQIARSLKYPDTKVKGNGNYKFALYTSKHCHYSVEKGAILLGLGSENVFKVDVDENGVMDVDSLKQVIEKTKKEGYTPLYINATAGTTVFGSYDPFLEISKVAKEHNIHFHIDGSWGGNVIFSPKYRDRLAGSEYADSITVNPHKMLGIPNTCSFLLLPQVANFQTAMSLKAPYLFHGRESGSDENYDLADGTMGCGRRSDAFKFYLGWLYYGEQGFAKRVEHAYSIMEYFVQSIRSNPNFEIVGPQSPQCLQVCFYYHPATVNKSNTEITRYVSRKLHKLGKYLVDFSPNPVDDTQGEFFRVVFNSPILSDKIVDELIASIISVGKELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPP7</accession>
    <name>C4YPP7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_02448</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPP7"/>
    <dbReference type="PaxDb" id="5476-C4YPP7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02448"/>
    <dbReference type="HOGENOM" id="CLU_038617_1_1_1"/>
    <dbReference type="OMA" id="WCRHCKK"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF3">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07749">
        <property type="entry name" value="ERp29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47933">
        <property type="entry name" value="ERP29 C domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005667907" description="protein disulfide-isomerase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="17"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="159"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ44186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="414" mass="47091" checksum="89EC0493A845BFE0" modified="2009-07-28" version="1">MMKLLSIITTVLYFFTFLVSSYTTSNIIQANDNNLQSLIKTRGKFSFVDFYADWCRHCKKISPIIDELSELFIDYPEIQIIKINGDKDGKKMSKKYVDIGYPTLLFFYDDGKKIEFDGIRDLTSLSNFIQQLSGIRLNESKSTDNNEEEEEKKEKKESSSSGSSSNVNDAVEETNKLIELTPENFDEKVSQSPISIVSFGASWCKYCQELDTALDKLANEVYIRDSNNNNNNNNKKKIMIGHIVIDQYQNNSIDKRYNIQDLPTVLFFQNGDLQSPLVYKGKKNFHNLLNDINKFTGLNRDAQGNLNNEAGIINEISQLIKNYYNSGDNELEIFDELEKVKTSTSISTSGGGGNDDGDDNDDVIGYYEKLINAKEYIPIELSRINNILQNDIDKLNGITIDSLTKRANILRSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPR8</accession>
    <name>C4YPR8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_02470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPR8"/>
    <dbReference type="PaxDb" id="5476-C4YPR8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02470"/>
    <dbReference type="HOGENOM" id="CLU_915257_0_0_1"/>
    <dbReference type="OMA" id="IDGAEIC"/>
    <dbReference type="OrthoDB" id="4018997at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946801" evidence="3">
        <location>
            <begin position="23"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ44207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="307" mass="32340" checksum="0F66FB2F804B4C76" modified="2009-07-28" version="1">MLSINNLLILSIFSFLITNVKSDLGGPCFSMSTMEGFACGLGVHKNIQIITDCLCYIPGYWEQLDGCDKLVRGPHHTPIDGAEICSRASEYAANPAGFTGETDYYESSTTVMHVVMLDFPTYSPGVTNFLDSSSNDLTTTNTDEINSSITTDEVIPSSSSSYIEIPSETLMESSISTQPSTIETSETSNATSLEVSSIITGVSSEPLTIVSESGGLSSTEIASTPVVITSPTPQPLLETPSQESSAPDIDSTTPTTIDNTVVDETTTNDATSVASSTSDVAYVYIGGAMGYPSISVALGLVFIAYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPW2</accession>
    <name>C4YPW2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">ATP-dependent RNA helicase DBP5</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">ATP-dependent RNA helicase dbp5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">CAWG_02516</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29 30">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. May also be involved in early transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Associates with the nuclear pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPW2"/>
    <dbReference type="PaxDb" id="5476-C4YPW2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02516"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="OMA" id="IAAETRW"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17963">
        <property type="entry name" value="DEADc_DDX19_DDX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000318">
        <property type="entry name" value="ATP-dependent RNA helicase DDX19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 24" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 24 29" id="KW-0347">Helicase</keyword>
    <keyword evidence="8 24" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="15" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7 24" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="14" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="28">
        <location>
            <begin position="147"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="26">
        <location>
            <begin position="180"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="27">
        <location>
            <begin position="358"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="23">
        <location>
            <begin position="147"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="52"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00037213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00038143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00038750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00039326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00039604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="EEQ44251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="537" mass="59898" checksum="4DC7E38191E654FC" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPY4</accession>
    <name>C4YPY4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60S ribosomal protein L12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_02538</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPY4"/>
    <dbReference type="SMR" id="C4YPY4"/>
    <dbReference type="PaxDb" id="5476-C4YPY4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02538"/>
    <dbReference type="HOGENOM" id="CLU_074237_5_0_1"/>
    <dbReference type="OMA" id="QPPHDVI"/>
    <dbReference type="OrthoDB" id="1478556at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_uL11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="7">
        <location>
            <begin position="14"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="6">
        <location>
            <begin position="74"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ44273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="165" mass="17763" checksum="A81F7713BB824169" modified="2010-10-05" version="1">MPPKFDPNEVKFLYLRAVGGEVGASSALAPKIGPLGLSPKKVGEDIAKATKEYKGIKVTVQLRIQNRQATASVVPSASSLVITALKEPVRDRKKEKNVKHSGNIPLDEIFEIARKMQHKSFGKNLASVSKEILGTAQSVGCRVDGKNPHDIIDAINAGEIDVPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQB8</accession>
    <name>C4YQB8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="7">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_02675</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine and inosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="7"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQB8"/>
    <dbReference type="SMR" id="C4YQB8"/>
    <dbReference type="PaxDb" id="5476-C4YQB8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02675"/>
    <dbReference type="HOGENOM" id="CLU_054456_1_2_1"/>
    <dbReference type="OMA" id="EGVYAQF"/>
    <dbReference type="OrthoDB" id="10261782at2759"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000004">
        <property type="entry name" value="Purine nucleoside phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011270">
        <property type="entry name" value="Pur_Nuc_Pase_Ino/Guo-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01700">
        <property type="entry name" value="PNPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006054">
        <property type="entry name" value="PRK08202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="METHYLTHIOADENOSINE/PURINE NUCLEOSIDE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904:SF9">
        <property type="entry name" value="PURINE NUCLEOSIDE PHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="9">
        <location>
            <begin position="35"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="97"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ44407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="307" mass="33433" checksum="61AF23F672AB821D" modified="2010-10-05" version="1">MAENIPPEEYIKQLNHASDTIKHKIDQFPELTQPRVMIICGSGLGGIADVLQAEPKLEIPYSKIPGFKISTVPGHAGKLVFGLIGKKKVPVMCMVGRLHFYEGYSFQETTFPVRVAQLLGISSVVVTNAAGGINPKFKPGDLMVIEDHINFPGLAGYHPLRGPNLSEFGPRFQPLSDAYDYELRKLFLTTARDKLGITRNIYEGTYFFAAGPTFESRAEVRMIKTMGGDAVGMSTVPEVIVARHSGLRVLALSLITNAGVGDKPPSAFDENPPALDEGMASHAEVLEAADEASKDVQRIIEEVINQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQD2</accession>
    <name>C4YQD2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_02689</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQD2"/>
    <dbReference type="SMR" id="C4YQD2"/>
    <dbReference type="PaxDb" id="5476-C4YQD2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02689"/>
    <dbReference type="HOGENOM" id="CLU_011226_15_2_1"/>
    <dbReference type="OMA" id="WIHFAES"/>
    <dbReference type="OrthoDB" id="2098326at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000156">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="96"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ44421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="249" mass="28654" checksum="DCD49A2543777ED3" modified="2009-07-28" version="1">MSDTKIIVHWLNYSRSQRVIWLLEELNIPFELKVYLRNKQFRAPKELENVHPLGKSPVIEVIDTKTGESEVIAETGHIFNYILSNYDTTNILTPANRKLQNQVDYFLHYAEGTLQPNLVALLVHGFAKQQAPFGTKFLMGLLVNGIDSMFYIPELKKNLNYLEDIMRKQHENGSNYFVGDKLSGADIILEFPVITNIFQNKRGAEQLGAGDVEKEYPHLNQWAEDIKKEPKYIKAQELVAKHETVKPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQD6</accession>
    <name>C4YQD6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_02693</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQD6"/>
    <dbReference type="PaxDb" id="5476-C4YQD6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02693"/>
    <dbReference type="HOGENOM" id="CLU_023995_4_2_1"/>
    <dbReference type="OMA" id="RSQWMRR"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="344"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ44425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="576" mass="65586" checksum="505D0BA644E80FD9" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQU2</accession>
    <name>C4YQU2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_04439</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQU2"/>
    <dbReference type="PaxDb" id="5476-C4YQU2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04439"/>
    <dbReference type="HOGENOM" id="CLU_034311_1_0_1"/>
    <dbReference type="OMA" id="PGMREPK"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="6"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="43"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ46095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="344" mass="38327" checksum="E0B29CE58CBB2F6B" modified="2009-07-28" version="1" fragment="single">IILISAGVVGLYTGFSLLEKGVAANEITVIAEYLPGDESINYTSPYAGGNFSCITGDDPQTLQYDKYTYLNLPKIQKAIGGKTQGLDRYPSTEYWDEKPSQTKIESLESYLQDYKEVIDESLPSGSKFGIKFLAWNFNCPKFLFNLQQYLQSQGVKFIRKKLTHIVQAYFSESTKIVFNCTGIGARSIGGVEDKNVYPGRGQVVVIKAPHIMENVLSWGDREPTYIIKRPYSNDQLILGGYFQKDDWTAATLKEQTQDILQRTTSLFPKILKENPNGNKIEDLEILRVAAGLRPCRYGGARIEKEVVESGKILIHNYGASGYGYQAGYGMANKATDLALGKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQZ9</accession>
    <name>C4YQZ9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQZ9"/>
    <dbReference type="PaxDb" id="5476-C4YQZ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04496"/>
    <dbReference type="HOGENOM" id="CLU_042296_0_0_1"/>
    <dbReference type="OMA" id="IDLRFYR"/>
    <dbReference type="OrthoDB" id="3357002at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021460">
        <property type="entry name" value="DUF3112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184">
        <property type="entry name" value="YALI0C10208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11309">
        <property type="entry name" value="DUF3112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="500" mass="56824" checksum="C71B698B1CFAC0D4" modified="2010-10-05" version="1">MVMPNPKEYTAIHGVSRLLTYLNNYPAEGTGTLFLSEKAKNLMGPKLPQILVEYSTATQLNLFGNYPEKSDVAPSALFIALFSIIAILHLTVFSINYYRGHYFWLSLGWVFYAICRVLGFALRIVWSRDLTDCKVGITSEVFLIVPTVLIASFNLVLAQRIFTWRHPVGGSRRIFWTLMWILYALVAGVVAMTIVTSAGLNIYLLSEANYARYKKVIMCTSVLIIVYSLTAVGLILLAWLFKPTKKDENLYTYQPWWIESFSPFYFVKKGEPQAAAISFLKRNHNHRYAIRVIAATHHLHKTVKGLTNQRGDLTHNVSLMIIGVTTLIILVSSILRSIICFQGRMMYFTSPVGSPAVMYVFWGALEFGVNLLYIIGRVDLRFYRPDRLPKDVRNVVTAEQSLYPSEIEDEGEDQEVLDKESLDKVPQPYSGEEPSTNNNHDDNGFSFGFSDSDEKDNHTDHDGHKDHDGFDFTNGASEKPKNNLPYPFKEKSDTVSEFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRH8</accession>
    <name>C4YRH8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Dipeptidyl aminopeptidase B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_04678</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S9B family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRH8"/>
    <dbReference type="ESTHER" id="canal-q5ag57">
        <property type="family name" value="DPP4N_Peptidase_S9"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.006"/>
    <dbReference type="PaxDb" id="5476-C4YRH8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04678"/>
    <dbReference type="HOGENOM" id="CLU_006105_0_1_1"/>
    <dbReference type="OMA" id="MRTPQEN"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF200">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 10, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="15">
        <location>
            <begin position="173"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="14">
        <location>
            <begin position="623"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEQ46331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="838" mass="96368" checksum="6BA8D7354FDAE04F" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRV5</accession>
    <name>C4YRV5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease T2</fullName>
            <ecNumber evidence="4">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAWG_04812</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Rnase which modulates cell survival under stress conditions. Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death. Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19" evidence="4"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRV5"/>
    <dbReference type="SMR" id="C4YRV5"/>
    <dbReference type="PaxDb" id="5476-C4YRV5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04812"/>
    <dbReference type="HOGENOM" id="CLU_037966_0_1_1"/>
    <dbReference type="OMA" id="HESLWIH"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.730.10:FF:000004">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057328">
        <property type="entry name" value="RNaseT2L_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25488">
        <property type="entry name" value="RNaseT2L_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946860" description="ribonuclease T2" evidence="18">
        <location>
            <begin position="18"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="RNase T2-like C-terminal" evidence="19">
        <location>
            <begin position="293"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR633697-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF25488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEQ46458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="399" mass="42733" checksum="CBE909B5994F7E03" modified="2009-07-28" version="1">MLSILSIAALLIATVQAADFSSSCPIDSPISCSSNGDTSNSCCYENPGGIILFTQFWDYNPASGPADSFTIHSIWNDYCSGGYPQFCDTSLEIDSTGSTIESIVVDQFGDQTLYDNMNKYWTDINGNNKKFWAHEFNKHGTCLNTLNPSCYSNYKQNENVYDYYSLVYQLFQKLPTYQWLVSAGIKPSTTATYTLSQIQSALKSKFGAEVYIACDSNNAINEVWYFYNIKGSILQQNYLPIDTVSKTNCPSSGIKFPPKGNSGANTLTTKTTGTTTSGSGSTSVPATSYINLTGKSGCLISNGKYYTSGTCATYHFNAGSSGNTQITSSKGNCGIDSSNQFTCSSSTSATDFQVSGGSIGYNGNFDWCLGAVTGSGSTAQTSVKLSDGSCSSFKLTLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRY8</accession>
    <name>C4YRY8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Crh-like protein</fullName>
            <ecNumber evidence="16">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CAWG_04846</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="16"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRY8"/>
    <dbReference type="PaxDb" id="5476-C4YRY8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04846"/>
    <dbReference type="HOGENOM" id="CLU_027506_2_1_1"/>
    <dbReference type="OMA" id="GRYHEMH"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000432">
        <property type="entry name" value="Glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="10 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944438" description="Crh-like protein" evidence="21">
        <location>
            <begin position="19"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="22">
        <location>
            <begin position="18"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="304"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="17">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="43"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EEQ46491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="505" mass="57279" checksum="56EE0CFD9F7C2BDA" modified="2009-07-28" version="1">MYKQILTFLILFLRYILSEFPDDPYEDDDTSDDNNSDYEGQKCNPYRDKACLVNDEALGKKIFESFAEGTKYFTITSSTRGVRFGSEGLALTIQDEFDNPALVSSFYIMYGKVEAEIKGAAGKGIISSFYLQSDDLDEIDVVEIFGSDPYEFQTNFFIKGNTTTYDRGRYHEMHPSPLSEFHKYGIEWSPDLITWYLDDKPVRMLGRRNKHGLPCSPMFLKFSLWSVEDDDEGTIAWAGGAASFSEGPFTMHIKNLKVQDYSKALTYSYGNLRDGNWLDLRADGGYLYEGHKYCLPPKMLDKLKPTPKQETDDDQVFTSSKSQRVATKISKDKNTVSYYPHSATNSHTTWDRLSEWETEQDETGTDDTENSDNEEEEESITAIPISKSRKGSTRRLDISTQLPPLSQNESKIAEIKNITTTKHIHNTTTSLQISKIESKKVRVTTTIYSSSTPQSTSKSRMPYNIFFNYPGKENSRFKSGVSSILATSFSSVVIAEILVIVVLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS95</accession>
    <name>C4YS95_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA/RNA-binding protein Alba-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS95"/>
    <dbReference type="PaxDb" id="5476-C4YS95"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04955"/>
    <dbReference type="HOGENOM" id="CLU_1594303_0_0_1"/>
    <dbReference type="OMA" id="IAKLICI"/>
    <dbReference type="OrthoDB" id="4020196at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA-binding protein Alba-like" evidence="1">
        <location>
            <begin position="32"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="171" mass="19693" checksum="5345293D2668E20B" modified="2009-07-28" version="1">MAESTLETEYSKQSNHIFNELGKQLLDKDNIKVVKITKNDSIKNKVEAIFKSIKQDKLILLTGLSNSIAKLICITEIVKQKQNEQQQQQHEPSQKLDQYNKLLHIDSTVNPSYKPIPEKENKKVDTKQLEKEALQEIKGPKIYTLPVLYIVIGKHSIVSNIELVNWTKQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT42</accession>
    <name>C4YT42_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_05741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT42"/>
    <dbReference type="SMR" id="C4YT42"/>
    <dbReference type="PaxDb" id="5476-C4YT42"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05741"/>
    <dbReference type="HOGENOM" id="CLU_1916804_0_0_1"/>
    <dbReference type="OMA" id="ELMEGWN"/>
    <dbReference type="OrthoDB" id="4090463at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ47178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="135" mass="15779" checksum="2562835C7B350E5B" modified="2010-10-05" version="1">MTLTKYQRGDLIEGWNDCPVPLAHKEPLQHASLQQEIDTHKVIDILNKLFQCNIDLPEREIKHYETKLVNSVDKMSKSNINFVYHMCDRILQYQSQGSFSEVRNELKNEVIEYMMVHEGVSSWCSPLKKIITSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT63</accession>
    <name>C4YT63_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_05762</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10 11">WO-1</strain>
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    </reference>
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        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
    <comment type="similarity">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
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    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="121" mass="14008" checksum="7FB083B36D209BDC" modified="2009-07-28" version="1">MRYTSLLNHGDTTNPSKLLLQIVILQCFYYLSALVIFYLVASLNGYDFKIDWVFSWELVEPDNAMGLTLFMMWLFDALLCVLFVTVIVGRSKLAWDMAVTVYIINLIVVWTYTGKFPFSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTD3</accession>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
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                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
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                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
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                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
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                <person name="Berriman M."/>
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                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 7"/>
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        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
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    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
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        <property type="entry name" value="GLYCOGEN-BINDING SUBUNIT 76A"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
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            <end position="550"/>
        </location>
    </feature>
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        <location>
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            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="671" mass="73597" checksum="F546280E208F17D4" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTJ6</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05489</name>
    </gene>
    <organism evidence="2 3">
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            <taxon>Pichiomycetes</taxon>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="HOGENOM" id="CLU_070357_0_0_1"/>
    <dbReference type="OMA" id="ICILRFQ"/>
    <dbReference type="OrthoDB" id="4015819at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="373" mass="44244" checksum="2BC6B8886E6445BA" modified="2009-07-28" version="1">MYTTNTLLDEKSFSLSQKYSIYHQPFTNTYQSNRYIYIIDKYFCKFIHNPIISSIILILSYTYYYYYYYYYNNDNYNYDDYYLPQYLFVNDLVSNIINLICILRFQYRFKFNHLIGELIFFIGQSILSYQLIINQLLIHFNESTATTTTTTTTGTGTGTSTINCTLIIQWTIILQMILPIIILVFTYVDNYRNRNRNNDNNDNYTSGGLGGLYSVIFEGNNHYIPVFLSYSFFLININLINANTTTTTTSSSFSSTGSINTISNWFLELTFQQLIKFIYQLSCFSFKFYLMYQFILYELSINQIGFKKFINYQEFYPKLKEEDEEEEEDKNAITTTTTKRLNIINFLKSDQFKNMLMILVCLIIIIIDIIQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTJ9</accession>
    <name>C4YTJ9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_05492</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTJ9"/>
    <dbReference type="PaxDb" id="5476-C4YTJ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05492"/>
    <dbReference type="HOGENOM" id="CLU_069841_0_0_1"/>
    <dbReference type="OMA" id="QDEINCK"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000283">
        <property type="entry name" value="NAP1-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF116">
        <property type="entry name" value="CAP, ISOFORM AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="124"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="254"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="268"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ46940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="335" mass="38168" checksum="04D7E3547E953476" modified="2009-07-28" version="1">MTSHFPPNTKIKDFGYPETHPFHIGNYLLKSNGSISSSPTSSTTSSSASSSSTTSSSAFISNKHGNHHHHHHHHHLPNNYMTNSSQFISSNDYNNTNNINDDDDDDDDNDNDDDIIEDDYDQDEINCKARAIFDFSAENDNEISLIEGQIIWISYRHGQGWLVAEDPISGENGLVPEEYVEIMQNLDNKNKKKHKNKSININGDYQEFGHQYGNGSNNQDEDVPKRFLPEIFNDHIHQDDDDDDVDCDSEWVDTDYEEEEEEEEAEKEQEREKQQPQEGKEEPKMEIAKLEQPVNKESEINGETITTTTATITTTTTTTSKKINAIEKKLNDVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTK8</accession>
    <name>C4YTK8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_05503</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTK8"/>
    <dbReference type="PaxDb" id="5476-C4YTK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05503"/>
    <dbReference type="HOGENOM" id="CLU_008455_11_4_1"/>
    <dbReference type="OMA" id="IPAFMGY"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF31">
        <property type="entry name" value="POLYAMINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="536"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="573"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="165"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ46949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="610" mass="67593" checksum="E0D8C851F37B2C55" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTN0</accession>
    <name>C4YTN0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Golgi SNAP receptor complex member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_05525</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of several multiprotein Golgi SNARE complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GOSR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTN0"/>
    <dbReference type="SMR" id="C4YTN0"/>
    <dbReference type="PaxDb" id="5476-C4YTN0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05525"/>
    <dbReference type="HOGENOM" id="CLU_078034_0_1_1"/>
    <dbReference type="OMA" id="QAYAVND"/>
    <dbReference type="OrthoDB" id="422156at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048219">
        <property type="term" value="P:inter-Golgi cisterna vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023601">
        <property type="entry name" value="Golgi_SNAP_su1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094:SF2">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094">
        <property type="entry name" value="GOS-28 SNARE- RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027109">
        <property type="entry name" value="Golgi_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR027109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ46971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="224" mass="26008" checksum="1CEBE9F32034EC7C" modified="2010-10-05" version="1">MSSSTFSQTRSQALSLEKQTEQLLSKFSQFQQQQQQNQSQSLDITPEETIIRQQIEEIFQKRNAVISKLNRISEVEPNLSTSKLQQLTRHKEKLNDDNLSFTKIINNIEDERNKNNLLFNVHRDINHHKQQRNIDGNAYILEESERVNNVNSIADRLLQGAFATRDELLNQRQYLNNAQSQVLSTMQNIPGLNVLISKINTRRKRDTLILASVIAICILFLFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTN7</accession>
    <name>C4YTN7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RuvB-like helicase</fullName>
            <ecNumber evidence="16">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAWG_05532</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="16"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTN7"/>
    <dbReference type="SMR" id="C4YTN7"/>
    <dbReference type="PaxDb" id="5476-C4YTN7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05532"/>
    <dbReference type="HOGENOM" id="CLU_028311_4_0_1"/>
    <dbReference type="OMA" id="IINTEPY"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002221">
        <property type="entry name" value="RuvB-like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000002">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="12 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="10 16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="71"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="458"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="461"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEQ46978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="498" mass="54549" checksum="5ADE8A14BCEF2786" modified="2009-07-28" version="1">MATNTITTTKVTTTTTDVTGLSLIAAHSHISGLGLDDNLQPKENAQGMVGQLSARKAAGVILKMVEAGKIAGRAVLIAGPPSTGKTAIAMGLSQSLGNQVPFTALAASEVFSLELSKTEALTQAFRKSIGIKIKEETEIIEGEVVEIQIDRTITGGHKQGKLTIKTTDMETIYELGNKMIEGLTKEKVLAGDVISIDKASGKITKLGRSFTRARDYDAMGPETKFVQCPEGELQKRKEVVHTISLHEIDVINSRQQGFLALFSGDTGEIRPEVRDQINTKVAEWKEEGKAEIVPGVLFIDEVHMLDIECFSFINRALEDEFSPIVIMATNRGVSRIRGTDYKSPHGMPMDLLDRSITIHTTSYTADEIRTILSIRATEEEVELSGDALALLTKIGQETSLRYAANLISVSQQIALKKKNNTVDLQDIKRAYMLFLDSDRSVQYLEENADQYIDDYGRVTIGQESTDGSTQPQAKQQEVAQPEATQPQSQPEDDKMETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTT0</accession>
    <name>C4YTT0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTT0"/>
    <dbReference type="PaxDb" id="5476-C4YTT0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05575"/>
    <dbReference type="HOGENOM" id="CLU_083354_1_0_1"/>
    <dbReference type="OMA" id="CKNINDP"/>
    <dbReference type="OrthoDB" id="4018368at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944464" evidence="1">
        <location>
            <begin position="20"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="152" mass="16665" checksum="14568422D14B0C83" modified="2010-10-05" version="1">MKFFTAATTALLFSAQALAGITSYTLSIKSDDERVNGKGITYKHEGAGINYAFVSDTSSKFAYDDESKLLYYPASPQLKYNFGTEADIIQFSVTPPKSVEIGEDGVLKFEDSDKLYAAVSINDPYHYSDSDFAIILRGKPHAIPIQIVAEKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>P0CB55</accession>
    <accession>Q5AI88</accession>
    <name>GET3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase GET3</fullName>
            <ecNumber evidence="1">3.6.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Arsenical pump-driving ATPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Arsenite-stimulated ATPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Golgi to ER traffic protein 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Guided entry of tail-anchored proteins 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">GET3</name>
        <name type="ORF">CAWG_01107</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1 and GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-GET2 receptor, and returning it to the cytosol to initiate a new round of targeting. Cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in low-level resistance to the oxyanions arsenite and arsenate, and in heat tolerance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Component of the Golgi to ER traffic (GET) complex, which is composed of GET1, GET2 and GET3. Within the complex, GET1 and GET2 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer. Interacts with the chloride channel protein GEF1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
        <text evidence="1">GET1 and GET2 are required for targeting GET3 to the endoplasmic reticulum.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arsA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0CB55"/>
    <dbReference type="SMR" id="P0CB55"/>
    <dbReference type="PaxDb" id="5476-P0CB55"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01107"/>
    <dbReference type="HOGENOM" id="CLU_040761_0_0_1"/>
    <dbReference type="OMA" id="MDAPYEF"/>
    <dbReference type="OrthoDB" id="1770at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001359">
        <property type="entry name" value="ATPase GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000388195" description="ATPase GET3">
        <location>
            <begin position="1"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <sequence length="350" mass="39604" checksum="D32532E15835AF3B" modified="2009-11-03" version="1">MDFELEPSLEELIKQDTLKWIFVGGKGGVGKTTTSSSIAVQLALQHPNDEFLLISTDPAHNLSDAFCQKFGKDARKVEGLSNLSCMEIDPEAAMSDLQQQAQQYNNDPNDPLKSIMNDMTGSIPGIDEALSFMEVLKHIKNQKVNESDDSKDKISYRTIIFDTAPTGHTLRFLQLPSTLQKLLGKFQQLSGKLGPMMSMLGGGGQGQQDMFAKLNEVQKNVEEVNEQFTNPDLTTFVCVCISEFLSLYETERMIQELMSYQMDVNSIVVNQLLFADDDENPCKRCVARWKMQKKYLDQMAELYEDYHLVKMPLLGSEIRGVENLKKFSKFLIKPYDPKVDRGIITDLKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCL4</accession>
    <name>C4YCL4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_00248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EEQ42050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YCL4"/>
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    <dbReference type="HOGENOM" id="CLU_006977_0_0_1"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058155">
        <property type="entry name" value="Skg3/CAF120-like_PH"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="162"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
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            <end position="476"/>
        </location>
    </feature>
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        </location>
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            <end position="10"/>
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    </feature>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="1000"/>
            <end position="1013"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ42050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1013" mass="114191" checksum="6A6A906B7F3E87B0" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCP5</accession>
    <name>C4YCP5_CANAW</name>
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        <recommendedName>
            <fullName evidence="3">DOPA-dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_00279</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
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                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
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                <person name="Berriman M."/>
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                <person name="Lorenz M.C."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">WO-1</strain>
        </source>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="14749" checksum="EB8C7BBEFA61E262" modified="2009-07-28" version="1">MGEDHEFYGGIKSYDVHTYYGNEKEEKLAFALREKVLKDFAKEIENGEIKVYKFWEKPIGPHPIRMWELDFKDPEIFKVVVPYFQLNHGPLSVLIHPRTDQGDLKDHTEHALWLGHKVRLDTSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCW3</accession>
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    </protein>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
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                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
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                <person name="Neiman A.M."/>
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                <person name="Quinn J."/>
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                <person name="Sherlock G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="15 16">WO-1</strain>
        </source>
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        </subcellularLocation>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
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        <property type="entry name" value="SWIRM"/>
    </dbReference>
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        <property type="entry name" value="TADA2A_B-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF20">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 2-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22941">
        <property type="entry name" value="TADA2A-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025024">
        <property type="entry name" value="Transcriptional_adaptor_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="12">
        <location>
            <begin position="5"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="14">
        <location>
            <begin position="63"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="11">
        <location>
            <begin position="68"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="SWIRM" evidence="13">
        <location>
            <begin position="357"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="319"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR025024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ42149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="445" mass="51110" checksum="906898F5F06FF2F2" modified="2009-07-28" version="1">MDSRTKLFHCDVCSSDCTNRIRIQCAICTDYDLCVPCFAAGLTTGDHKPWHDYQIIEQNTYPIFDRDWGADEELLLIQGCETSGLGNWADIADHIGNRSKEEVAEHYFKIYLESKDYPLPEMNKDFTDVSPLQFLEERKERLEKRKNIPLPPPRGKPVASVPLCHEIQGYMPGRLEFDHEAENEAEIPIKDMVFDPEDSANDIDLKLTILDIYNSRLTTRAERKRVMILNHLLDYRKNIGSDKRKSKEEKDLLKKINAFIRILTPEDFESFSRDLLTELKCRMKIQQLQTWRRNGITTLEDGAKFEKDKVIRAAHYQRMGNGTGSGRHSQTPGLTNGNSFNGNGHRNKFSPQPEFRSKSTTARAPLDISHAADFELLSAEEKQLCATLRILPKPYLAIKNQLMREAVKNNGVLKKKDARQALKIDVNKASKIYEFFVHMGWCSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCX2</accession>
    <name>C4YCX2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein transport protein SFT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_00356</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCX2"/>
    <dbReference type="PaxDb" id="5476-C4YCX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00356"/>
    <dbReference type="HOGENOM" id="CLU_099529_3_0_1"/>
    <dbReference type="OMA" id="GLMFFTR"/>
    <dbReference type="OrthoDB" id="660759at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF36">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ42158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="217" mass="24417" checksum="D22C0D169D562E5E" modified="2009-07-28" version="1">MSTESENVFRQSFRNWNDRSNRTTTSSTSNRPVLSEWTDYFKTGANDLYNRLPSSVQDIGATNNNVQEPSWYNLSRLERLIGFGCCLGASVLCFVLCFFMLPVLALRPRKFGLLWTGGSVLFVVSFGVLQGPYNYVRHLLSRDRILFTGVFFSSVFLTIYSACILKSSILTIFTSIIEILAVLYYTLSYFPFGATTLTFFTSYVVGYVGGLIGGVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCY8</accession>
    <name>C4YCY8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCY8"/>
    <dbReference type="PaxDb" id="5476-C4YCY8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00375"/>
    <dbReference type="HOGENOM" id="CLU_2170710_0_0_1"/>
    <dbReference type="OrthoDB" id="10395592at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="110" mass="12432" checksum="6C7C7A709EAD55BA" modified="2010-10-05" version="1">MFQHLNIIATTQQLQHNTPTMLLSQYQTYQLFINQLISIFASFESLLCKVSNRIIFIIWFPIILFFIFDIVSCLSVKLLLNYNLLDNGGATTATHHASNAAGVTTHRGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD37</accession>
    <name>C4YD37_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_00425</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD37"/>
    <dbReference type="PaxDb" id="5476-C4YD37"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00425"/>
    <dbReference type="HOGENOM" id="CLU_013298_1_2_1"/>
    <dbReference type="OMA" id="CEFAKNQ"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ42223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="606" mass="69649" checksum="0A1DAA31A673C4AA" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD38</accession>
    <name>C4YD38_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD38"/>
    <dbReference type="PaxDb" id="5476-C4YD38"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00426"/>
    <dbReference type="HOGENOM" id="CLU_131045_0_0_1"/>
    <dbReference type="OMA" id="GVINKNQ"/>
    <dbReference type="OrthoDB" id="4083131at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="170" mass="19325" checksum="4F6FDBFEF03692F2" modified="2010-10-05" version="1">MFKSSFNASSFIPTWFKKSSTSTQSNAVDPSTIPRNFTISNTDNKLINVSMNNVQHDDDEFIDIETKPLSYAEVASLGKNKKQTNMAKPSKGVINKNQFNVLNDKDINANEDSDKDVIHGKEVDNYQYDPIKSGDEYDKSKSYKLKQQKSVHKKKQLHREFKAQKLKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDC0</accession>
    <name>C4YDC0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_00511</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDC0"/>
    <dbReference type="PaxDb" id="5476-C4YDC0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00511"/>
    <dbReference type="HOGENOM" id="CLU_014489_0_0_1"/>
    <dbReference type="OMA" id="NWGGRTK"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="102"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="215"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="284"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ42306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="876" mass="99166" checksum="83840CB5BDCB7DA9" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDK3</accession>
    <name>C4YDK3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Lysophospholipase</fullName>
            <ecNumber evidence="2 10">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_00600</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the release of fatty acids from lysophospholipids. Phospholipase B may well contribute to pathogenicity by abetting the fungus in damaging and traversing host cell membranes, processes which likely increase the rapidity of disseminated infection.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="2 10"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDK3"/>
    <dbReference type="PaxDb" id="5476-C4YDK3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00600"/>
    <dbReference type="HOGENOM" id="CLU_014602_0_1_1"/>
    <dbReference type="OMA" id="TDWWGRA"/>
    <dbReference type="OrthoDB" id="4084751at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07203">
        <property type="entry name" value="cPLA2_Fungal_PLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000010">
        <property type="entry name" value="Lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF33">
        <property type="entry name" value="LYSOPHOSPHOLIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 9 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005125141" description="Lysophospholipase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="12">
        <location>
            <begin position="114"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="687"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="687"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ42389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="754" mass="81426" checksum="7AE9D301C800F80B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDL2</accession>
    <name>C4YDL2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_00609</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDL2"/>
    <dbReference type="PaxDb" id="5476-C4YDL2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00609"/>
    <dbReference type="HOGENOM" id="CLU_013817_2_0_1"/>
    <dbReference type="OMA" id="GLESHYQ"/>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000186">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF156">
        <property type="entry name" value="INACTIVE TRNA-SPECIFIC ADENOSINE DEAMINASE-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="113"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ42398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="275" mass="31833" checksum="F750FFAB4285B77F" modified="2009-07-28" version="1">MSFIKTHFSLEDVTTPCLNHLKRIRKVDDHLEVIIYPYESDEQCASIMELSRKFPEEFSIDNLEVKEVPQNAPPTKELTQQWSNGYWPITWKGNPNHQFLNSVEIDIEQEKQMINTLLDSLADAAVSQDFTFNFSGTLIASKEDDRIEIHTICIASDINNDPQGHSVMEAISKIAEREVMNRKSNQSERGYLCNDMLVYTTHEPCVMCCMALVHSRIGRIIYLKPEKSSGGLESHYQLGDRDGLNWKFEIWRWLGVDELARLDRINENRCPCIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDL6</accession>
    <name>C4YDL6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTP-binding protein 128up</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_00613</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in ribosomal function.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDL6"/>
    <dbReference type="SMR" id="C4YDL6"/>
    <dbReference type="PaxDb" id="5476-C4YDL6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00613"/>
    <dbReference type="HOGENOM" id="CLU_044997_0_0_1"/>
    <dbReference type="OMA" id="SAKHPGQ"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17230">
        <property type="entry name" value="TGS_DRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="65"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="291"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ42402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="368" mass="40356" checksum="B5D9A7DBB9D70732" modified="2010-10-05" version="1">MTTVEKIKAIEDEMAKTQKNKATSFHLGQLKAKLAKLRRELLSEGSGSGGGGAGVGFDVARTGVATVGFVGFPSVGKSTLLSKLTGTHSEAAAYEFTTLTTVPGTIKYKGAKIQMLDLPGIIEGAKDGKGRGRQVIAVARSVNLIFLVLDVNKPLQHKKIIEHELEGMGIRINKEPPNIVITKKDKGGINITNTVPLTHLDNDEIRAVMSEYKINSANIAFRCDATVDDLIDAIEAKARKYIPAIYVLNKIDSFSIEELNLLAKIPDAIPISSANGWNLDDLLQMMWDKLKLVRVYTKPKGKLPDFNEPVVLRSDRCTVEDFCNSIHKSLVEDFRNALVYGTSVKHQPQIVGLNHQLEDEDVITILKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YED2</accession>
    <name>C4YED2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_00889</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YED2"/>
    <dbReference type="PaxDb" id="5476-C4YED2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00889"/>
    <dbReference type="HOGENOM" id="CLU_062255_0_0_1"/>
    <dbReference type="OMA" id="NDACCEE"/>
    <dbReference type="OrthoDB" id="423462at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="199"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="281"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="281"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="337"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="132"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ42668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="371" mass="42012" checksum="3F5769C5EF9634AE" modified="2009-07-28" version="1">MNRSSYSSQSDNRYSRNPAVLCSFYSKIGACRHGEKCSKKHLKPISSRTILLANLYQNPTLNDDDYGHANGIGSETSQIIDNESVIKNSDTVGTVSQIDDSPHSNSGEVTKDETVETQEVETENSENIAETGDVKIDHNEDQKQIKDVKESDKVESSEEVQQDDKLHKEDTLEKESEDNIKQDENIEDAKLEDTEKDKLPEFTISQSQKDFDQFFQDIFVHISKLGQIRDIAVCENENNHLAGNVYVMFESAEDAYNANLQLNQEWFNGKPVYSDLSPVNDFNDACCEEYRDYHDCQRGAMCNYMHVRLPSSDIEESLYESQAKSYMLKQLEELKKELPGDIRSSSSTNDDETNGNENGISSTMAVLEQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEF8</accession>
    <name>C4YEF8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_00915</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
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        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acid sphingomyelinase family.</text>
    </comment>
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        <property type="protein sequence ID" value="EEQ42694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="C4YEF8"/>
    <dbReference type="PaxDb" id="5476-C4YEF8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00915"/>
    <dbReference type="HOGENOM" id="CLU_014743_2_0_1"/>
    <dbReference type="OMA" id="WIIAHLP"/>
    <dbReference type="OrthoDB" id="282973at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Acid sphingomyelin phosphodiesterase, putative"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ASM_C"/>
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        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
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    <dbReference type="PANTHER" id="PTHR10340:SF27">
        <property type="entry name" value="ACL091CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19272">
        <property type="entry name" value="ASMase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946388" description="Calcineurin-like phosphoesterase domain-containing protein" evidence="10">
        <location>
            <begin position="19"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="11">
        <location>
            <begin position="328"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingomyelin phosphodiesterase C-terminal" evidence="12">
        <location>
            <begin position="565"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ42694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="703" mass="80952" checksum="F067C73E727EBFEB" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF15</accession>
    <name>C4YF15_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_01125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YF15"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01125"/>
    <dbReference type="HOGENOM" id="CLU_004495_2_3_1"/>
    <dbReference type="OMA" id="CFIMVWL"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF16">
        <property type="entry name" value="7-KETO 8-AMINOPELARGONIC ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ42901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="503" mass="55735" checksum="1E7AF8F0171B717F" modified="2009-07-28" version="1">MSYQITEKKDLTYVITENSIPQAQLEKNFSLLSTCAFQFTLICSALAIGTFLSTVIGVGGSPVLIFGFIVAITFDLIICYSLAELASAYPHSSAQVHWTYCLASEKYKRSLSFLTGILSCAGWIFACFSSTYVASMFILALAQIYHQDYIPKSFHYYLVYLAVFLSGYLVNVFLVKLLPLITNISVAVINFGTFFIIITLLVKSPKQSAEFVFKNIINETGWSSNGVVFFLGMLPSLACVTLFDGAVHLTDEIAQPERNIPLVMVISNTLSGVMAFFAAIVYMFCVVNVNNLSNPLGGEPIVQLMYDSFQSEALTTIGVVCLILTFVGSSYMYYTSTSRLIWSFANSNGLPFSKYIGEVSLNLKSPVYALSFLTVLCIIIGTLIMGSDGALNAVLGTSMVCINLSYLIPIACLLVKSKFSTTHRFNERPYFCLGKFGLPMNIASVLWVCFIMVWLNFPLSYPVTSDNMNYACVVLGITCIIGIILWFVHGRNHYDHNIDFKHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF25</accession>
    <name>C4YF25_CANAW</name>
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        <submittedName>
            <fullName evidence="13">Bud site selection protein 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_01136</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF25"/>
    <dbReference type="PaxDb" id="5476-C4YF25"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01136"/>
    <dbReference type="HOGENOM" id="CLU_117291_0_0_1"/>
    <dbReference type="OMA" id="VNMLKFM"/>
    <dbReference type="OrthoDB" id="24683at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000299">
        <property type="entry name" value="Zinc finger protein 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="145"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ42911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="176" mass="20784" checksum="1E98FCD2C6E1B6DD" modified="2009-07-28" version="1">MGRYSVKRYKTKRRTRDLDLIYNDLSSPESINKLKNQPLDELKPGLGQYYCIQCAKYFENQISLDRHTKSKIHKRRVKSLNERPYTPLEAEAAAGVNMEKFIASVEKYKQLENDKQENKHQYDKLINQKKDNLDAIITGIPSEEFQQQKQQQQQEELQDANQRTVSNDQEEVMMID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFD9</accession>
    <name>C4YFD9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_01256</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFD9"/>
    <dbReference type="PaxDb" id="5476-C4YFD9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01256"/>
    <dbReference type="HOGENOM" id="CLU_006909_5_0_1"/>
    <dbReference type="OMA" id="MVTPLWK"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ43025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="463" mass="52946" checksum="4B0212B5B8C22829" modified="2009-07-28" version="1">MTKEQIDEPRYKRIAVIGGGPTGLAAVKALSLEPVNFSCIDLFERRDRLGGLWYHHGDKSLVKPEIPNLSPSQEEIVSDNATPADEYFSAIYEYMETNIVHQIMEYSGVAFPANSKKYPTRSQVLEYIDDYIKSIPKDTVNISINSNVVSLEKVNEIWHIEIEDVIKKTRAKLRYDAVIIANGHFSNPYIPDVSGLSSWNKNYPGTITHSKYYESPAKFRDKRVLVVGNSASGVDISIQLSVCAKDVFVSIRDQESPHFEDGFCKHIGLIEEYNYETRSVRTTDREVVSEIDYVIFCTGYLYALPFLKQERNITDGFQVYDLYKQIFNIYDPSLTFLALLRDVIPMPISESQAALIARVYSGRYKLPPTEEMERDYQLELKEKGRGGKFHNYKYPQDVAYCQMLQTLIDEQGLHTPGLVAPIWDESLIKKRSETKAEKNARLKNVVEHVKCLRAEGKDFSLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFG9</accession>
    <name>C4YFG9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipid:diacylglycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_01287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFG9"/>
    <dbReference type="PaxDb" id="5476-C4YFG9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01287"/>
    <dbReference type="HOGENOM" id="CLU_016065_1_0_1"/>
    <dbReference type="OMA" id="FYFLKWV"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
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                <person name="Sakthikumar S."/>
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                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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                <person name="Forche A."/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
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    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="7">
        <location>
            <begin position="113"/>
            <end position="180"/>
        </location>
    </feature>
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            <begin position="323"/>
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        </location>
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    <feature type="repeat" description="WD" evidence="5">
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        </location>
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            <begin position="419"/>
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        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="184"/>
            <end position="219"/>
        </location>
    </feature>
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        <location>
            <begin position="12"/>
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        </location>
    </feature>
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            <begin position="37"/>
            <end position="77"/>
        </location>
    </feature>
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        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ41980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="517" mass="57669" checksum="20B5F90942924B01" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGA5</accession>
    <name>C4YGA5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_00226</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="TLIHHAF"/>
    <dbReference type="OrthoDB" id="4094515at2759"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="entry name" value="Mso1_C"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF14475">
        <property type="entry name" value="Mso1_Sec1_bdg"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Mso1 membrane-polarising" evidence="3">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
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        </location>
    </feature>
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        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ42029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="171" mass="19609" checksum="8AD98C28B9DB54CA" modified="2009-07-28" version="1">MQHTSAGGGFFSKIKENYSSKLAGLSLAGGPYVEKDGSSEDNTLIHNAFVKYYDSKGLPYPDWLGVKTFQSQQQQQQQGYVRTQYQQDYSQSKYQPVRQDNTFNNSYNARQTQQQQQQQQQHQQQTNGSDRPNSGGYQRSSSRLQDLYNKSRQQSIPGQGYNTSNSWSHNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGD2</accession>
    <name>C4YGD2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sister chromatid cohesion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_03108</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SCC2/Nipped-B family.</text>
    </comment>
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        <property type="protein sequence ID" value="EEQ44814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGD2"/>
    <dbReference type="PaxDb" id="5476-C4YGD2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03108"/>
    <dbReference type="HOGENOM" id="CLU_004334_0_0_1"/>
    <dbReference type="OMA" id="YLPFQFV"/>
    <dbReference type="OrthoDB" id="418242at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090694">
        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061775">
        <property type="term" value="F:cohesin loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026003">
        <property type="entry name" value="Cohesin_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024986">
        <property type="entry name" value="Nipped-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12765">
        <property type="entry name" value="Cohesin_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12830">
        <property type="entry name" value="Nipped-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Sister chromatid cohesion C-terminal" evidence="8">
        <location>
            <begin position="803"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ44814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1046" mass="118291" checksum="E4A463F5B1C1E2EB" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGD4</accession>
    <name>C4YGD4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_03110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGD4"/>
    <dbReference type="PaxDb" id="5476-C4YGD4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03110"/>
    <dbReference type="HOGENOM" id="CLU_011607_0_0_1"/>
    <dbReference type="OMA" id="LHCMKYP"/>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000093">
        <property type="entry name" value="Cell division cycle-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="76"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ44816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="400" mass="47454" checksum="14E7B6BADEA24EE6" modified="2009-07-28" version="1">MNTLRRRRIPKPIPRIFEDDEYKQYTRPHNWRLLSLVGICWVLLIHYFERTRPQNTLSTCQWKNWEQWNSPDSAHRIVLIADPQIVDDYSYPKQFKIINYFTKKLADNYLHRNYEMIHSVLAPDTTIFLGDLFDGGRYWDDKQWIDEYKRFTKIFPKKINRRDIRSVPGNHDIGFQTIRHKVVKRFAEYYGELNDYIELGNHTLVLLDSISLSHPDKLIRKEPDNFLDQLNNRISSTFPRILLTHVPLFRNPATQTCGPHREKRKPFPLQRGDQYQTVIEYEISRRILNTIKPTLIFAGDDHDYCDITQEYDGGAAREITVKSAAMTGGIKHPAVQLLSLNTNEPTRTYETEMCYMPNAYHGLYAYITFLLLTSFFIDRSIVFLNLVWPLFILNVYYMTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGF1</accession>
    <name>C4YGF1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">6-O-methylguanine-DNA methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">DNA repair MTase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_03127</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="2"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGF1"/>
    <dbReference type="PaxDb" id="5476-C4YGF1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03127"/>
    <dbReference type="HOGENOM" id="CLU_000445_52_2_1"/>
    <dbReference type="OMA" id="YTFIETE"/>
    <dbReference type="OrthoDB" id="1907495at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815:SF13">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="8">
        <location>
            <begin position="96"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ44833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="175" mass="19494" checksum="7A6321362D4EE161" modified="2009-07-28" version="1">MSNLYYTVFDTDVCTVLLVLTLNGFVCYASLGKPAIELKGIMAKDFSSLPYQLKPLSTMTGDKIEIDKSVEKFKLLVETPSVSQDIKTELIFGTPLQRKVWKELVKIPAGQTRTYKELADLLGIHSRVIGNCCGANRIAVLISCHRVVGANNKLTGYRWGKSYKEYLLKQEGIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGP4</accession>
    <name>C4YGP4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chitobiosyldiphosphodolichol beta-mannosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.142</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Asparagine-linked glycosylation protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Beta-1,4-mannosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">GDP-mannose-dolichol diphosphochitobiose mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAWG_03225</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13865"/>
            <dbReference type="Rhea" id="RHEA-COMP:19510"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57269"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="EC" id="2.4.1.142"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:13866"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.142" evidence="4"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGP4"/>
    <dbReference type="PaxDb" id="5476-C4YGP4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03225"/>
    <dbReference type="HOGENOM" id="CLU_012079_0_0_1"/>
    <dbReference type="OMA" id="CKLIIDW"/>
    <dbReference type="OrthoDB" id="614844at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004578">
        <property type="term" value="F:chitobiosyldiphosphodolichol beta-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000109">
        <property type="entry name" value="Chitobiosyldiphosphodolichol beta-mannosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026051">
        <property type="entry name" value="ALG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036">
        <property type="entry name" value="BETA1,4 MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036:SF0">
        <property type="entry name" value="CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 20" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="19">
        <location>
            <begin position="263"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEQ44926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="456" mass="52413" checksum="C6128581D89CA4F9" modified="2009-07-28" version="1">MGEIIKYKGFDHVWQYSGPWLYCLIGIYISLPVLAYHILPWIFHKNKSNKRKTISIFVLGDLGHSPRMCYHALSFSKLDYYVNLCGYVETEPSHQIVDDVNIDIIPIEAIKNTSNLPFIMFAILKVVRQCRKIWSILWDTRGSDYIMIQNPPSIPILLIVILFKTVFSRETKLIIDWHNLNYTILNLRYNNLNHPFVKLVKLYEKFLGQFANLNITVTKSMKKYLVKEFGFQKSKIVTLYDRPGVQFQPLSNKREFMSEHKLFEDIDIEKYKVLISSTSFTPDEDFNILLDALKNYENTPNTPPILLIVTGKGPLKGKFLETVDKLEFTNKVCVKSAWLSSEDYPKVLACADLGISLHTSSSGIDLPMKIVDFFGCGVPVVSLDFPAIDELVKNKVNGLITNSKSDQTKEVARLVTEVFTDDALLRSIKEGALEESNSRWDENWMQTFSSIFENKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGR1</accession>
    <name>C4YGR1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_03243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGR1"/>
    <dbReference type="PaxDb" id="5476-C4YGR1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03243"/>
    <dbReference type="HOGENOM" id="CLU_1602460_0_0_1"/>
    <dbReference type="OMA" id="KQCEYIF"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ44943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="187" mass="21761" checksum="106CAAA0508804C9" modified="2009-07-28" version="1">MDSGYSISSYNEDLENLKNQEMYDFYKIDEDFRITFIPFTQEDTFSKNYEYWKTILTNELEQLVVSIKGKNFSISIETKEEPMYVVSLRVPWGHVKQCEYIFKSEFLQEKDVIVATQLPKKTTLQTFTTPMVNAYFVVKLKGDKVPPKRVMYSGEMVTARVLTNVKSCVFCYSKEHTVMECPHAGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGT5</accession>
    <name>C4YGT5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Golgi vesicle protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_03267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGT5"/>
    <dbReference type="PaxDb" id="5476-C4YGT5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03267"/>
    <dbReference type="HOGENOM" id="CLU_059017_0_0_1"/>
    <dbReference type="OMA" id="NIMFATR"/>
    <dbReference type="OrthoDB" id="5549748at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd07600">
        <property type="entry name" value="BAR_Gvp36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018859">
        <property type="entry name" value="BAR_dom-cont"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10455">
        <property type="entry name" value="BAR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ44967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="36167" checksum="77AAC7599AEB0814" modified="2010-10-05" version="1">MSFNFSNFTKDLKSFGDKISTEFNKEVVPLAQRTSRLVQEKMGNIKQDDISQLPSEYIELANKCNNIEQLYKNVLKITTNYENESYDYPTNVQESFTEFGKNITTRVSNVAKATTTAEAQAALINPNTGEFKAPKTLYHALSRATDASILTSDKSQDPLIKGLDLYSSNLNKIANARLGQDQLIKSKFNKPLLTTLRSLISQSNNIQKKVEDKRIDYDLTRSNLASCTNPQKEPKLRVDMENAEDEFANTVEDAINIMQNVLENAKPLEEFLELIKAQLAYHKLATELLDGMVKDFEELIDEQHKLSGSATSGRESGDFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGT9</accession>
    <name>C4YGT9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="19">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CAWG_03271</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">NADH-dependent reductase for DPH3 and cytochrome b5. Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. By reducing DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71231"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:71232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 19">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer. Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="19"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGT9"/>
    <dbReference type="SMR" id="C4YGT9"/>
    <dbReference type="PaxDb" id="5476-C4YGT9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03271"/>
    <dbReference type="HOGENOM" id="CLU_003827_9_0_1"/>
    <dbReference type="OMA" id="VQIFMCG"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18 19" id="KW-0274">FAD</keyword>
    <keyword evidence="5 18 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="11 19" id="KW-0520">NAD</keyword>
    <keyword evidence="10 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="21">
        <location>
            <begin position="51"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EEQ44971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="294" mass="32472" checksum="EC4D6DB09B6733B4" modified="2009-07-28" version="1">MSETTTVPPIETVSEPNPFIVFATVATIISAFIGYYFLQQSKKHTPVLKPDEFQKFPLIEKIRVSHNSAIYRFGLPKSTDRLGLPIGQHISIGATIDGKEVVRSYTPISTDDQLGHFDLLIKTYENGNISRHVAGKNVGEHIEIRGPKGFFTYTPNMVKSFGMIAGGTGIAPMYQIITAILKNPEDKTKIHLVYANVTESDILLKEELDNFAARHPDRLKIHYVLNEAPANWQGSVGFVTPEIIDTHLPKASNDTNLLLCGPPPMVSAMKKAAVELGFQKAKPVSKLGDQVFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH08</accession>
    <name>C4YH08_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_03349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YH08"/>
    <dbReference type="PaxDb" id="5476-C4YH08"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03349"/>
    <dbReference type="HOGENOM" id="CLU_075125_0_0_1"/>
    <dbReference type="OMA" id="HPRYYIT"/>
    <dbReference type="OrthoDB" id="4025944at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ45040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="278" mass="32738" checksum="CEC51B15BFF2C497" modified="2009-07-28" version="1">MLRSQLPCIQKRTLFQKYSNPPRLSYVANKSYISLIWNNLIPQPLKLTCLVASGIVTFVNVHPRYYITLGPPVGLLGFFGYQKYRHWQYHKAVSKLDVTKWQDNEIIRIAKYDEKSLDNVIMGIDNQYDSLRRQIIQLVEQRIIEYISEHGVEDEITRSFISDDNQFNVHLPELEIESWVTTNVKLEKNNDTVSEFIMLSVPYYDSKNIHTRKRLGVVSIYLLQIPQQEHSSFIDYKIGIEVTRLRWINPQSLFFTKLESKALMQSDIYKSLNKENQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH29</accession>
    <name>C4YH29_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vac7p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_03370</name>
    </gene>
    <organism evidence="3 4">
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            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="348" mass="40547" checksum="3623E07377F3303A" modified="2009-07-28" version="1">MIIFYKFIEFFLQLINDKQILYQEMFQEYNKKFVNPKINQLKKDAMIDATLGPHYSISLNDQKPYSFSKSKVFIIHDIKGKPITEYGDIDSQILPQQLELEPLTSSCSTAINSRLTSRANSVAHYSNNNNDDYDRTFNTSSNWNQNRRYQQSSRYHSGRNNDNLIMNTPLTYLPQPSRYSTQTPSLNSNLSFNRYDRTPSPTRGTTMSRRYSNSNINNNNNNNNNHYIHSPSRIRSRPTSPNKLLSPTRQPRLEFDGIGNTTITNDDQDRDRFSPFKSPSPIHRGTYHHSSPNTVNPQQLHQQQQLSQQQQSSQHNNSFGYPNYPYRSPSPTRRRPSDSPERPKPGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHA1</accession>
    <name>C4YHA1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Spo75p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_03446</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHA1"/>
    <dbReference type="PaxDb" id="5476-C4YHA1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03446"/>
    <dbReference type="HOGENOM" id="CLU_002458_1_0_1"/>
    <dbReference type="OMA" id="QKWFFAF"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF20">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="538"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="633"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="658"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="698"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="731"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="50"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="224"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="8">
        <location>
            <begin position="443"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="9">
        <location>
            <begin position="792"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ45133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="861" mass="99132" checksum="CDBE9EE59F97081E" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHC4</accession>
    <name>C4YHC4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_03470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHC4"/>
    <dbReference type="PaxDb" id="5476-C4YHC4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03470"/>
    <dbReference type="HOGENOM" id="CLU_034311_3_0_1"/>
    <dbReference type="OMA" id="EYDTWVV"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF26">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_5G13940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ45156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="330" mass="37448" checksum="4A17AE9666D0BC3A" modified="2009-07-28" version="1">MIEKPHIVIAGAGILGLTTAWVIAENLSASNTPYEITIVAEYGPHSPTMHANLTNSAKYTSPWAGAHFRPFPSKNEQELKEMKLTRLTLQKFKQLSQTSPESSIKFVKGIEYLENPDEHYSKFAYGWSEEIDNFKHKTDKPGFLGVEYDTWVVNSPMYLQFLYRKLSIEYSNINFLKIRLDSLKQINDLFPKTKSRTAPIIINCTGNGLQYNGGFDPECYPIRGQTLLIKPPPSPQKNGTNQKCQYLDKTITYQLKDGSWSFVIPRPFNGGVILGGMKQIGLRLDVEQYDNKQYVINNYGAGGMGYELSYGAAIKVYEKLMEILGRRHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHN5</accession>
    <name>C4YHN5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_03583</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHN5"/>
    <dbReference type="PaxDb" id="5476-C4YHN5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03583"/>
    <dbReference type="HOGENOM" id="CLU_070882_2_1_1"/>
    <dbReference type="OMA" id="KAKCFYF"/>
    <dbReference type="OrthoDB" id="9936937at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058841">
        <property type="entry name" value="HTH_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040554">
        <property type="entry name" value="KPWE_PEX14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855:SF1">
        <property type="entry name" value="PEROXISOME MEMBRANE ANCHOR PROTEIN PEX14P N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25871">
        <property type="entry name" value="HTH_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17733">
        <property type="entry name" value="KPWE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEX14-like helix-turn-helix" evidence="3">
        <location>
            <begin position="8"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxisomal membrane protein PEX14-like KPWE" evidence="2">
        <location>
            <begin position="117"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="137"/>
            <end position="177"/>
        </location>
    </feature>
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        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ45267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="177" mass="20310" checksum="51F1C8AD535DB112" modified="2009-07-28" version="1">MSTTNTQEDVYIEYLNYDWDSFQEFQDGLQEIMDNYLQNLKEQDPSVTSIPNLDKQQLINQAKSFFFCNKTGNIINLDDFEDWKLHNEDKFKKDKQIEELGTSESTSTNNQSDSDPPYSSNYQELVGLLMSGKPIPGIKQIPDTVLTDQGSTASASQRTKPWEKNRSPETTEEVSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHP5</accession>
    <name>C4YHP5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_03594</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="PaxDb" id="5476-C4YHP5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03594"/>
    <dbReference type="HOGENOM" id="CLU_003874_0_0_1"/>
    <dbReference type="OMA" id="RYAKTKR"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005933">
        <property type="term" value="C:cellular bud"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09394">
        <property type="entry name" value="LIM1_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09395">
        <property type="entry name" value="LIM2_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
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        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF128">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN RGD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="34"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="8">
        <location>
            <begin position="979"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="961"/>
        </location>
    </feature>
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        <location>
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            <end position="186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="712"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
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            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="248"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="557"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="594"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="791"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="816"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="829"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="840"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="855"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="908"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="935"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ45277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1176" mass="131159" checksum="7D74F40EC18BA61D" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHU3</accession>
    <name>C4YHU3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_03646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EEQ45325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="C4YHU3"/>
    <dbReference type="PaxDb" id="5476-C4YHU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03646"/>
    <dbReference type="HOGENOM" id="CLU_011023_0_0_1"/>
    <dbReference type="OMA" id="CHYRTDD"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="224"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ45325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1183" mass="135953" checksum="DE5181919E468361" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIC2</accession>
    <name>C4YIC2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 21">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="6 21">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19 21">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18 21">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CAWG_04194</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 21">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </cofactor>
        <text evidence="21">A monovalent cation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 21">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 21">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="6 21"/>
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        <property type="protein sequence ID" value="EEQ45857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Mur ligase, C-terminal domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
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    </dbReference>
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        <property type="entry name" value="Folylpolyglutamate_synth_euk"/>
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    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038895">
        <property type="entry name" value="FPGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 21" id="KW-0436">Ligase</keyword>
    <keyword evidence="15 23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 21" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="23">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
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                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIR3"/>
    <dbReference type="PaxDb" id="5476-C4YIR3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04340"/>
    <dbReference type="HOGENOM" id="CLU_032690_2_1_1"/>
    <dbReference type="OMA" id="PTGERAF"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.210:FF:000004">
        <property type="entry name" value="Acyl-CoA thioesterase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025652">
        <property type="entry name" value="TesB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02551">
        <property type="entry name" value="Acyl_CoA_thio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="4">
        <location>
            <begin position="40"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase 2 C-terminal" evidence="3">
        <location>
            <begin position="199"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ45998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="298" mass="33909" checksum="44826CD20CFCA7B1" modified="2009-07-28" version="1">MTDLTTVHQLPYVDIASVFDVKQIETYRYRGIKPLQKQSSQHRGVFGGNFVAQSLLVAIRSAPHGFQPHTIHSYFVRAGDDKTPIEWEVDEITNGRTFANRAIRGFQNGKVVFTANVSLTSKNSVKDIVKKTGTMPVIFQKEVDTEYKDLKNNISKCPLFVENSNAHFTVRTFPINLSSDIYAFLSKFGAESKETVVGLTTEYQYVALATISDFVRLEEVFKIMGVDVDVSFNVSLDHSIYFHDNDFDATKWSTYLVEVTRWSHDRVMIVGKIYNDKGIHVASISQERLFVIKNKPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIV3</accession>
    <name>C4YIV3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 21">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="15">IMP dehydrogenase</shortName>
            <shortName evidence="15">IMPD</shortName>
            <shortName evidence="15">IMPDH</shortName>
            <ecNumber evidence="15 21">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CAWG_04382</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15 21">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15 21">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer. Seems to be able to form heterotetramers composed from more than 1 of the 3 IMPDH gene products (IMD2-4).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15 20">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="15 21"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ46038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIV3"/>
    <dbReference type="PaxDb" id="5476-C4YIV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04382"/>
    <dbReference type="HOGENOM" id="CLU_022552_2_1_1"/>
    <dbReference type="OMA" id="MGYCGAK"/>
    <dbReference type="OrthoDB" id="416622at2759"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000007">
        <property type="entry name" value="Chromosome 19 SCAF14664, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 15 21" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5 15 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15 17" id="KW-0520">NAD</keyword>
    <keyword evidence="9 15 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 15 18" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 15 21" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="22">
        <location>
            <begin position="119"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="22">
        <location>
            <begin position="182"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="15 16">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15 16">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15 17">
        <location>
            <begin position="276"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 17">
        <location>
            <begin position="326"/>
            <end position="328"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 18">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 18">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 18">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="366"/>
            <end position="368"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="389"/>
            <end position="390"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="413"/>
            <end position="417"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EEQ46038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="521" mass="56223" checksum="4E28C870B5A752A9" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIX1</accession>
    <name>C4YIX1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exoribonuclease phosphorolytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ46056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIX1"/>
    <dbReference type="PaxDb" id="5476-C4YIX1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04400"/>
    <dbReference type="HOGENOM" id="CLU_063514_2_1_1"/>
    <dbReference type="OMA" id="SYKCPAT"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="6">
        <location>
            <begin position="7"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ46056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="266" mass="30220" checksum="682BD546D5E96B8D" modified="2009-07-28" version="1">MSLSSSIGLRTSIIDNADGSAELSIYNNNSNNNSNEASSSSSSDDNSIIKLITSINGPIEPKQRQELPNRASLEINIYPSIGLSTTKEKLLENKLRSILQNNIIINYKYPRQLIQISIQFLISSGSSSNYGSMMMNLLDLNALINCCYFALIDANIAMNYSFASIVIIIDHQGNLLIPIDGNDLHQQQQQEEDYESIHLCCYSIIAKKVDKLLLLESQGDFNESQLFNVLEKSIYKVEKFHNEIHRQFINDKIKNDYIWKQEREDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ07</accession>
    <name>C4YJ07_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cystathionine beta-lyase</fullName>
            <ecNumber evidence="3">4.4.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cysteine-S-conjugate beta-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_03819</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L,L-cystathionine + H2O = L-homocysteine + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13965"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:18121"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29256"/>
            <dbReference type="ChEBI" id="CHEBI:58717"/>
            <dbReference type="EC" id="4.4.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from L-cystathionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.13" evidence="3"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ07"/>
    <dbReference type="SMR" id="C4YJ07"/>
    <dbReference type="PaxDb" id="5476-C4YJ07"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03819"/>
    <dbReference type="HOGENOM" id="CLU_018986_2_1_1"/>
    <dbReference type="OMA" id="NCIGATG"/>
    <dbReference type="OrthoDB" id="2545919at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047804">
        <property type="term" value="F:cysteine-S-conjugate beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000013">
        <property type="entry name" value="Cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000009">
        <property type="entry name" value="Cystathionine gamma-synthase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006238">
        <property type="entry name" value="Cys_b_lyase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01329">
        <property type="entry name" value="cysta_beta_ly_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF50">
        <property type="entry name" value="CYSTATHIONINE BETA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 13 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ45491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="404" mass="44803" checksum="40365D5CBFBF525D" modified="2010-10-05" version="1">MSPKKSYSLETELVLNKSGDQYNASVPPLYQSATFKQPSLSNMGEYDYTRSGNPTRTHLQNHIAKIMKAEHAFAVSSGMGCLDVITRLLKPGDEVIAGDDLYGGTHRLLTYLSKKGDIVAHHYDTTNTELIKSKINNKTKMIFLESPTNPLIKVVDVKSIADHAHKANRDIVVVFDNTMMSPVLMTPLDLGVDIQYESATKYLNGHHDIMAGVIATRSSSLAEQLYYIINSTGCGLSPFDCWLLSRGLKTLAIRVEKQQQNCIRIAKFLENIGFKVRYPGLKSHPQYELHSSMCSGYGAVLSFETGSVRLSEKIVENTDIFGIAVSFGCVNSLISMPCKMSHASIDAKTREEREFPEDLIRLCIGIENCDDLIDDLTKALLRSGAVKVNDRDELYNAVGIQPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ99</accession>
    <name>C4YJ99_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_03912</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the epsin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ99"/>
    <dbReference type="PaxDb" id="5476-C4YJ99"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03912"/>
    <dbReference type="HOGENOM" id="CLU_012678_0_1_1"/>
    <dbReference type="OMA" id="STEFYDI"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16991">
        <property type="entry name" value="ENTH_Ent1_Ent2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF110">
        <property type="entry name" value="EPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="8">
        <location>
            <begin position="10"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="144"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="297"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="409"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="484"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="337"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="497"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ45583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="522" mass="60102" checksum="4D3F7A6561716922" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJD7</accession>
    <name>C4YJD7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">U1 small nuclear ribonucleoprotein component SNU71</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_03950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNU71 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJD7"/>
    <dbReference type="PaxDb" id="5476-C4YJD7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03950"/>
    <dbReference type="HOGENOM" id="CLU_478950_0_0_1"/>
    <dbReference type="OMA" id="YDHHRSF"/>
    <dbReference type="OrthoDB" id="6275295at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="PWI" evidence="6">
        <location>
            <begin position="551"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
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                <person name="Brunke S."/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Sakthikumar S."/>
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                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
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                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
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                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
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                <person name="Kodira C."/>
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                <person name="Martin R."/>
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                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
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                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
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                <person name="Staggs R."/>
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                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
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                <person name="Berriman M."/>
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                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the YOS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJN0"/>
    <dbReference type="SMR" id="C4YJN0"/>
    <dbReference type="PaxDb" id="5476-C4YJN0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04048"/>
    <dbReference type="HOGENOM" id="CLU_152125_0_1_1"/>
    <dbReference type="OMA" id="VQTVMRM"/>
    <dbReference type="OrthoDB" id="15356at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013880">
        <property type="entry name" value="Yos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858:SF0">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08571">
        <property type="entry name" value="Yos1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ45714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10581" checksum="55C84867C062AFD8" modified="2009-07-28" version="1">MFGLGKLFYVIVLVINGIAVLSEDRFLNRIGWGSTTGQQNNGNIQAQFNQFNSGLDNTDGSVKTKLINLISAVRTLMRIPLIVVNITIIIYELILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJS8</accession>
    <name>C4YJS8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_04098</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJS8"/>
    <dbReference type="PaxDb" id="5476-C4YJS8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04098"/>
    <dbReference type="HOGENOM" id="CLU_086201_0_0_1"/>
    <dbReference type="OMA" id="RAKQPAM"/>
    <dbReference type="OrthoDB" id="441172at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF5">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="166"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ45762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="215" mass="24902" checksum="81A0018100D5DB4C" modified="2009-07-28" version="1">MGQQPSTPKITAQDRAIFQLKQQRDKLKQYQKRLNTIIEKQTELAKKAVLNKQPEKAKFYLRSKKQQESVISTTFDQLNNLEKLIGTIEFKLIEKDVVYGLQQGNKVLQKLNNEMQVEKIDALIDQLEDEKLKVDEVSELLGSVDQLNRSEEDEVDKEFQTLQEEIHGKIKQVTEEEEESNLPKVPNTKPMPEAPSNEIEEHTPQKETKHEPIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK56</accession>
    <name>C4YK56_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Helicase SWR1</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Helicase swr1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CAWG_05852</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SWR1 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YK56"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05852"/>
    <dbReference type="HOGENOM" id="CLU_000315_24_4_1"/>
    <dbReference type="OMA" id="AFQQWFG"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18003">
        <property type="entry name" value="DEXQc_SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000005">
        <property type="entry name" value="Photoperiod-independent early flowering 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000655">
        <property type="entry name" value="Protein PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.850:FF:000009">
        <property type="entry name" value="SNF2 family helicase/ATPase (Swr1)"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
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        <property type="entry name" value="HSA_dom"/>
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    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="SNF2-like_sf"/>
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        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
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        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF1">
        <property type="entry name" value="HELICASE SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 24" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="416"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="21">
        <location>
            <begin position="835"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="22">
        <location>
            <begin position="1367"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="187"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="537"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="686"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1586"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="461"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
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        <location>
            <begin position="555"/>
            <end position="571"/>
        </location>
    </feature>
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        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
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        <location>
            <begin position="639"/>
            <end position="652"/>
        </location>
    </feature>
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        <location>
            <begin position="701"/>
            <end position="711"/>
        </location>
    </feature>
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        <location>
            <begin position="712"/>
            <end position="723"/>
        </location>
    </feature>
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            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1591"/>
            <end position="1605"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00074297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EEQ47285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1641" mass="187744" checksum="D211D8079AAFF5C7" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKI8</accession>
    <name>C4YKI8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="195" mass="21448" checksum="A344EE69C32F8EE0" modified="2009-07-28" version="1">MVQVMIQQWSGNVQDQVMVPTMDQDRAQVVDRASDQDQVVAQVVAPTMVQVQVMDQVVDQDQAQVSTMDQVVVPTMAQVMDQVTASDSGQVMDQVTASDSGQVMDQAQDSEADSAQDSAQDSEADSVMDSAPTITMGQAQASVQVMDKIMELLPHQSVNQVHQPQLKAHHLPIQQLYSNKQIQEIISNSHYSMDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKK8</accession>
    <name>C4YKK8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_06014</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Biochem. Biophys. Res. Commun." volume="428" first="427" last="432">
            <title>Crystal structure of the Candida albicans Kar3 kinesin motor domain fused to maltose-binding protein.</title>
            <authorList>
                <person name="Delorme C."/>
                <person name="Joshi M."/>
                <person name="Allingham J.S."/>
            </authorList>
            <dbReference type="PubMed" id="23137538"/>
            <dbReference type="DOI" id="10.1016/j.bbrc.2012.10.101"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 346-346 AND 352-694 IN COMPLEX WITH ADP AND MG(2+)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="EEQ47437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PDB" id="4H1G">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.15 A"/>
        <property type="chains" value="A=346-346, A=352-694"/>
    </dbReference>
    <dbReference type="PDBsum" id="4H1G"/>
    <dbReference type="AlphaFoldDB" id="C4YKK8"/>
    <dbReference type="SMR" id="C4YKK8"/>
    <dbReference type="PaxDb" id="5476-C4YKK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06014"/>
    <dbReference type="HOGENOM" id="CLU_001485_12_4_1"/>
    <dbReference type="OMA" id="QDERHAM"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="EvolutionaryTrace" id="C4YKK8"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="354"/>
            <end position="690"/>
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            <begin position="1"/>
            <end position="53"/>
        </location>
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            <end position="208"/>
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            <begin position="23"/>
            <end position="38"/>
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        <location>
            <position position="363"/>
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            <end position="456"/>
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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        <source>
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            <dbReference type="PROSITE" id="PS50067"/>
        </source>
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            <dbReference type="EMBL" id="EEQ47437.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="694" mass="78925" checksum="561113221D874A8E" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKZ7</accession>
    <name>C4YKZ7_CANAW</name>
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        <recommendedName>
            <fullName evidence="6">UBX domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
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            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
    </feature>
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        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLQ2</accession>
    <name>C4YLQ2_CANAW</name>
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        <recommendedName>
            <fullName evidence="5">UBR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">CAWG_01771</name>
    </gene>
    <organism evidence="6 7">
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        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLQ2"/>
    <dbReference type="PaxDb" id="5476-C4YLQ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01771"/>
    <dbReference type="HOGENOM" id="CLU_025221_1_0_1"/>
    <dbReference type="OMA" id="DCGTERQ"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19677">
        <property type="entry name" value="UBR-box_UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040204">
        <property type="entry name" value="UBR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047506">
        <property type="entry name" value="UBR7-like_UBR-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ43533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="413" mass="47442" checksum="2B4438E719781F4E" modified="2009-07-28" version="1">MPYDPNECTYEMGELRQPLFACLTCSAENENQPIGVCYSCSIQCHSQHELVELFTKRSFVCDCGTTRMKNTKDGACKLRRHGKKESSGRKLSNSSATHSTYLELAAEDIPSSSNTYNQNYHGRFCGCKQVYNPLEETGHMIQCYFGFTCGEDWYHDRCVMGITFADEKANQKHGNSQEESVPDGTNIKTDISKAQSESADIDSIEKLQYFPKLETFDEFICWRCVTSFKDVFEDLDKHFPGVILSKLPRFSNTSTVEDWYAKREKLLEPCFKKIKIEESSGKLGKFHNQEYSLFLSNDFRFKLIDNYESLDHESKLYKFLLNNSFLFKDDPIFKPPEDDSEEDCYSSSNAGTGRALETLPRDKAIESIQAYDKIKSKLKDFFKPFAEQGKVVTEEEVRNFFGHIDDKNNDSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM02</accession>
    <name>C4YM02_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_01877</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM02"/>
    <dbReference type="PaxDb" id="5476-C4YM02"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01877"/>
    <dbReference type="HOGENOM" id="CLU_029455_0_0_1"/>
    <dbReference type="OMA" id="ITMFSNT"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04813">
        <property type="entry name" value="PA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000073">
        <property type="entry name" value="Zinc finger protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="376"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="444"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="578"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="456"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="507"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="590"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="621" mass="69959" checksum="D068FA72F68C3645" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM15</accession>
    <name>C4YM15_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">[acyl-carrier-protein] S-malonyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_01890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="1"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM15"/>
    <dbReference type="PaxDb" id="5476-C4YM15"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01890"/>
    <dbReference type="HOGENOM" id="CLU_030558_0_1_1"/>
    <dbReference type="OMA" id="AFHTPFF"/>
    <dbReference type="OrthoDB" id="541883at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050858">
        <property type="entry name" value="Mal-CoA-ACP_Trans/PKS_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681:SF1">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="5">
        <location>
            <begin position="23"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ43646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="341" mass="38285" checksum="01076B6809E6EC14" modified="2009-07-28" version="1">MWPITTLSKSKQHFRFFSKYAVTCPGQGLYRNGVLELVKTQKSLFQHYLDELDAAMNEKFSDKLFANNSETEAKQWLSKTANAQPAILASTCILSNLVETEHQISIIDNASYLLGHSLGEYTALVLSGIIDFTTGIKVVRRRGQLMEDLCSGQNYGMIALLIKPKFAKEVIELAQEHNVLGNINSNYQVVISGEITKLKEFIDILRKIQKMALIKAVQLPVSIPFHSEILKPVVPELKSLLDGALNDQKIPIISNLNGQVSYEKESTIRNILDANYQPVQWQKSIAYLENSPVSTIFNLGPGEALHGINKKYNVKSVSLDDVKSLDKNSEFMELKQQLKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM63</accession>
    <name>C4YM63_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM63"/>
    <dbReference type="PaxDb" id="5476-C4YM63"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01939"/>
    <dbReference type="HOGENOM" id="CLU_1184880_0_0_1"/>
    <dbReference type="OMA" id="MWADAED"/>
    <dbReference type="OrthoDB" id="4026150at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="244" mass="27824" checksum="7D193E4BD8FAB395" modified="2009-07-28" version="1">MTGLASRWATDETLVKQAIDQDSKSSQQHHNHNHHKKSGSDLEDSKWSKPITSKKSEALVSMWADAEDTSNSYPSPPSSRDSHGKHRNERRKSDSQHSHHKKRENVSPRKTKHNHDSTPRVRRDSPTHEDDEDNERGPMTAAAKAFAARFDKPTDKTAGNKHDHNRSTDGNSLAERLDKLSVSKQKKPNHRPHNTGSVKSETPRQDKSVVASEEDKQKEEKEKEELLKMLEELESQHLDWASME</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMI3</accession>
    <name>C4YMI3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_02065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMI3"/>
    <dbReference type="PaxDb" id="5476-C4YMI3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02065"/>
    <dbReference type="HOGENOM" id="CLU_2211613_0_0_1"/>
    <dbReference type="OMA" id="AHSKAPM"/>
    <dbReference type="OrthoDB" id="4014860at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018854">
        <property type="entry name" value="Psome_chaperone_3/4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10448">
        <property type="entry name" value="POC3_POC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="111" mass="12534" checksum="3CFF36B5A477A6B2" modified="2009-07-28" version="1">MTHLIEDININGIDYTIVITFNSKAHSKAPMSIYINQQGNQEMGDYIYTISSYSTYLNNSTNNDQIKSLNQLLVKKFNVPIFLNISGDIGTNSNVELFRSIVDLVEHSKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMK4</accession>
    <name>C4YMK4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMK4"/>
    <dbReference type="PaxDb" id="5476-C4YMK4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02086"/>
    <dbReference type="HOGENOM" id="CLU_015160_1_0_1"/>
    <dbReference type="OMA" id="ERGMYRY"/>
    <dbReference type="OrthoDB" id="9994419at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="638" mass="73283" checksum="8164220EC1F7E875" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMQ4</accession>
    <name>C4YMQ4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMQ4"/>
    <dbReference type="PaxDb" id="5476-C4YMQ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02138"/>
    <dbReference type="HOGENOM" id="CLU_599905_0_0_1"/>
    <dbReference type="OMA" id="CHPTTIE"/>
    <dbReference type="OrthoDB" id="4025926at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946765" evidence="2">
        <location>
            <begin position="24"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ43885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="455" mass="46418" checksum="E845A460D69566EF" modified="2009-07-28" version="1">MRSPSLAVAATTVLGLFSSSALAYYGNTTTVALTTTEFVTTCPYPTTFTVSTCTNDVCQPTVVTVTEETTITIPGTVVCPVVSTPSGSASASASASASSEEGSVVTTQVTVTDFTTYCPYPTTLTITKCENNKCHPTTIPVETATTVTVTGEVICPTTTSTSPKESSSEAASSEVITTQVTVTDYTTYCPLPTTIVVSTCNEDKCHPTTIEVTTPSTVVVPGTVVCPTTSVATPSQSEATSQPTTISSVVTTGVTTTDYTTYCPSPTTIVVSTCNEEKCHPTTIEVSTPTTVVVPGTVVHPSTSATIVTTTAEQPPASPEVSTIESVVTTPATLTGYTTYCPEPTTIVLTTCSDDQCKPHTVSATGGETVSIPATIVVPSSHTTQVEITVSSASVPASEKPTTPVTVAAVSSFPAVSTETPSLVTPAISIAGAAAVNVVPTTAFGLFAIILALIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMQ6</accession>
    <name>C4YMQ6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fructose-2,6-bisphosphate 2-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_02140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.46" evidence="2"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMQ6"/>
    <dbReference type="SMR" id="C4YMQ6"/>
    <dbReference type="PaxDb" id="5476-C4YMQ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02140"/>
    <dbReference type="HOGENOM" id="CLU_006383_1_0_1"/>
    <dbReference type="OMA" id="DKMAHTH"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000005">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="316"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="123"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="342" mass="39184" checksum="99BF24B102BDFCCD" modified="2010-10-05" version="1">MQVSIISKDEQISSKIYRYLKWLSIKSQVFEDTQSMLKWFKDNEDAEDTVALINSNVNPNEIPKHIEPLVISDSVDASDSTFVRINGSDQNIVINHVTSHLQSKIIYFALNLNKRKRAIWLSRHGESEFNLSGQIGGDANLSERGWAYARKLPSLVEKSCNGANLTVWTSTLRRTQQTASFLPFQKKLQWKALDELDAGECDGMTYEEIEQKFPDDFKARDDNKYEYRYRGGESYRDIVIRLEPIIMELERQENILIITHQAVLRCLYAYFMNVPQEESPWMSIPLHTLIKLEPGAFETIVTRIKADIPAVSTYKEKGTSQLGESTTNTSKSRDLISNSNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN30</accession>
    <name>C4YN30_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_02270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN30"/>
    <dbReference type="SMR" id="C4YN30"/>
    <dbReference type="PaxDb" id="5476-C4YN30"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02270"/>
    <dbReference type="HOGENOM" id="CLU_018629_0_0_1"/>
    <dbReference type="OMA" id="ARCHRLK"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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    </dbReference>
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        <property type="entry name" value="prtT"/>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
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        <location>
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            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ44011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="681" mass="78898" checksum="FAA9D1D87E14CD2E" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNE1</accession>
    <name>C4YNE1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mms22p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Mus7"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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            <end position="411"/>
        </location>
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            <end position="518"/>
        </location>
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            <end position="621"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="251"/>
        </location>
    </feature>
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            <end position="271"/>
        </location>
    </feature>
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        <location>
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            <end position="321"/>
        </location>
    </feature>
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            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1704" mass="196929" checksum="2C1BE9AAAF5DBC5B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNF1</accession>
    <name>C4YNF1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="3">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_01410</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="3"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNF1"/>
    <dbReference type="PaxDb" id="5476-C4YNF1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01410"/>
    <dbReference type="HOGENOM" id="CLU_045637_0_2_1"/>
    <dbReference type="OMA" id="CEPFKVE"/>
    <dbReference type="OrthoDB" id="9991235at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01414">
        <property type="entry name" value="SAICAR_synt_Sc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000392">
        <property type="entry name" value="Phosphoribosylaminoimidazole-succinocarboxamide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000015">
        <property type="entry name" value="Phosphoribosylaminoimidazole-succinocarboxamide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010568">
        <property type="entry name" value="PRK13961.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR synthetase/ADE2 N-terminal" evidence="11">
        <location>
            <begin position="13"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ43184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="291" mass="32968" checksum="6679706C8E93FBBF" modified="2009-07-28" version="1">MTSTNLEGTFPLIARGKVRDIYQVDDNTLLFVATDRISAYDVIMANGIPNKGKILTKLSEFWFDFLPIENHLIKGDIFEKYPQLEKYRDQLEGRSLLVRKLKLIPLEVIVRGYITGSGWKEYTKSKTVHGIPIGDVVESQQITPIFTPSTKAEQGEHDENITKEQADKIVGKELCDRIEKIAIDLYTKARDYAATKGIIIADTKFEFGLDGDKIVLVDEVLTPDSSRFWSAAKYKLGQSQESYDKQFLRDWLTANGVAGKDGVAMPEDIAVQTKQKYVEAYENLTGEKWQD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNS4</accession>
    <name>AIM23_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>Altered inheritance of mitochondria protein 23, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">AIM23</name>
        <name type="ORF">CAWG_02857</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AIM23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNS4"/>
    <dbReference type="PaxDb" id="5476-C4YNS4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02857"/>
    <dbReference type="HOGENOM" id="CLU_054408_0_0_1"/>
    <dbReference type="OMA" id="KVSWQIS"/>
    <dbReference type="OrthoDB" id="3996489at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029427">
        <property type="entry name" value="AIM23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14877">
        <property type="entry name" value="mIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000399529" description="Altered inheritance of mitochondria protein 23, mitochondrial">
        <location>
            <begin position="19"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="368"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="432" mass="50332" checksum="D2889B2AB05EEF01" modified="2009-07-28" version="1" precursor="true">MSLRIILKRDFSQCIRVLESGSKSPTIANRFQAQYGNKNNNMKRNTANNGTGNGNRFHNKYNNESRRPYPKTKYQQQQQQQQQQRKPQQHQQYIIDPRKIKFDNGTESARNAIEEIFNRVNQLQRNYQIQLITDSGLKKCHLSEILQKLDLSINGLQLIDKSTTTTTTTTTTTTTTTNTSDEDLPLIKIITVRDMINQYSTYLNNLKQLELIKLGSSKTLKTLDIKLKLEQKKSTTKEILMKWSINNNDFKLQKTNEIKKLINNNGGNGKSFLINMVYNKRNTNKPINTIFKRRSNTEEDEQELIEIELKRRQLLIENLQSLLTELNCKWTIEGDINTKMTFNVTPKGQPTTIEPSTTTNIVDEEIEDYNNNNNNDDGDCDEKKMNRTERKKRKSEQQKQKQKQKQQSKTNTNSNTAKEEDLDALYSFKIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNU6</accession>
    <name>C4YNU6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-conjugating enzyme E2 6</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">E2 ubiquitin-conjugating enzyme 6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin carrier protein UBC6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ubiquitin-protein ligase UBC6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_02879</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNU6"/>
    <dbReference type="SMR" id="C4YNU6"/>
    <dbReference type="PaxDb" id="5476-C4YNU6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02879"/>
    <dbReference type="HOGENOM" id="CLU_041481_1_0_1"/>
    <dbReference type="OMA" id="GWSVATI"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000023">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 J2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="16">
        <location>
            <begin position="5"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="196"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ44604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="243" mass="28254" checksum="6FB5357E5962101C" modified="2010-10-05" version="1">MASRQATKRLNKEYKSIQANPPPYIIAHPSEDNILEWHYVLTGPQDTPYEGGQYHGLLRFPPQYPFQPPSILMITPSGRFKPNTRICLSMSDYHPDTWNPAWSVSTILTGMLSFFTGEESTTGSINTSVNHRKVLAQKSKKFNVDNDRFCREFPDLVKQYHEEIAAEKVKLEQQEKEQQLNGQQQGDQKEQLANLEDLDPEDRIRVMQQLEQEQKQKQKQKQNQDDENLNQDNDNSNRMCVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNW6</accession>
    <name>C4YNW6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_02899</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the laat-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNW6"/>
    <dbReference type="PaxDb" id="5476-C4YNW6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02899"/>
    <dbReference type="HOGENOM" id="CLU_019699_1_0_1"/>
    <dbReference type="OMA" id="DMCIFIQ"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000012">
        <property type="entry name" value="Vacuolar membrane PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF35">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER YPQ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ44625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="331" mass="36938" checksum="CB6A0D80D60E4DC3" modified="2009-07-28" version="1">MIAPPPAPIVLDSQSVSGITGSISIACWIIVFAPQIYENFKRKSSEGLSLTFIVLWLAGDVFNVLGAVLQGVLPTMIILAVYYTLADIVLLWQCLAYGDGKNPDLIHLSPANPLNEDVLETAMSNEERHNRRRNQGNTTEDLESSTTSIDSSISKSSSSQFQSFLINTLMVTLVIASGVIGWYISYIKESKHHSKHPGKHNPEELIFDPLAQIFGWLCAFFYLGSRIPQIVLNYERKSCDGISFMFFLFACLGNLTYVISILSIDMSWNYLWVNSSWLAGSLGTLGLDFTIFIQFFLYNENKDDEFSEYESSSETESESLLTSSDRSYGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNW7</accession>
    <name>C4YNW7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_02900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="HOGENOM" id="CLU_005934_1_0_1"/>
    <dbReference type="OMA" id="RYYFAWG"/>
    <dbReference type="OrthoDB" id="4159781at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="53"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="919"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="919"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="931"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="957"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ44626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1102" mass="126633" checksum="10FDD8E05F84EE69" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNX4</accession>
    <name>C4YNX4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_02907</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNX4"/>
    <dbReference type="PaxDb" id="5476-C4YNX4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02907"/>
    <dbReference type="HOGENOM" id="CLU_000022_45_4_1"/>
    <dbReference type="OMA" id="IWHSYER"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="172"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ44633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="754" mass="85509" checksum="AC4CDEA38F89DE13" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNX5</accession>
    <name>C4YNX5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_02908</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNX5"/>
    <dbReference type="PaxDb" id="5476-C4YNX5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02908"/>
    <dbReference type="HOGENOM" id="CLU_338885_0_0_1"/>
    <dbReference type="OMA" id="KEDHFHI"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF3">
        <property type="entry name" value="FI21236P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="374"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="204"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="495"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="501"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="562"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ44634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="764" mass="84635" checksum="543A01CA2C8D1C19" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP43</accession>
    <name>C4YP43_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_02981</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SLC12A transporter family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YP43"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02981"/>
    <dbReference type="HOGENOM" id="CLU_001883_4_0_1"/>
    <dbReference type="OMA" id="FYDFVKH"/>
    <dbReference type="OrthoDB" id="2020542at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034486">
        <property type="term" value="P:vacuolar transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000013">
        <property type="entry name" value="Solute carrier family 12 member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="86"/>
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            <end position="169"/>
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            <end position="211"/>
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            <end position="239"/>
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        </location>
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            <end position="463"/>
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            <end position="516"/>
        </location>
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        <location>
            <begin position="72"/>
            <end position="558"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010593"/>
        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ44702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1302" mass="144007" checksum="73C24F6FDE987847" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP84</accession>
    <name>C4YP84_CANAW</name>
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        <recommendedName>
            <fullName evidence="3">P-type ATPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">CAWG_03030</name>
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        <name type="scientific">Candida albicans (strain WO-1)</name>
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        <lineage>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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        </lineage>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
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    </dbReference>
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    </dbReference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ44743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="503" mass="56524" checksum="E6C07DE5A0D4BA93" modified="2009-07-28" version="1">MSNYNRTDNSKSNANPNPNANPNNPFSDNANNLIDLDLESNPYGDFNPNHVYPQTQRNTTTNTTTTTTTPHDPFADQFVLTDDSDEDNDDDDVDGHNTHNTSFASSSQNRQVPLLNTANIPKSPTNRFFNTHNANNNEYINMTDKQETSRDFDITHIFRKLKSKITGKPANLGLNDRQQSHQQQQPREINIMNHSANAGFGYYGNHISTTKYNIATFLPKFLFEQFSKYANLFFLVTSIIQQVPHVSPTNRYTTIGTLIVVLVVAAIKEMFEDIKRANADKELNRTKVLVLDPVTGNFTLKKWIKVQVGDVVQVLNEEPFPADLILLSSSEPEGLCYIETANLDGETNLKIKQAIPETAHLVNPRDLVKDLNNAQILSEQPNSSLYTYEGNLKNFRRGPDIPLSPEQMLLRGATLRNTQWINGVVIFTGHETKLMRNATAAPIKRTDVERIINLQILALFGVLIVLALISSIGNVIKVKVDGDKLGYLQLEGISMAKLFFQIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPN8</accession>
    <name>C4YPN8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin-like protein ARP9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YPN8"/>
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    <dbReference type="HOGENOM" id="CLU_052064_0_0_1"/>
    <dbReference type="OMA" id="RYIFEKT"/>
    <dbReference type="OrthoDB" id="74201at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="entry name" value="Actin-like protein ARP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="54572" checksum="60B456954C806C12" modified="2009-07-28" version="1">MPLYKEDNFLIIYPGSKHTLFLFGLSDTLSPPQFKIPSIVYQDSITKQYQATSNSENATEEIYPIIESKIVNLDAFNYLLKIILQSVIANHPTITINQIPMLLITPSLTWSRQSIEYITKYVIENLEITAFNIIDLSLAATFGVGQSTNSTVVYADDENIQIVPVVGYQAIKFAGKLIKNEGSITISRELKQNLPNLTSQQIEDLKNSDIFEVVIDQQGMVLDYIKDITKTNNDEDNEFDVAKIVTENQNGIPEAIISNTPTEQQQKEQQDSNKPNKELEKNYFIDSKTQEKIWIGKERFSGTNNLVKLISSSIYSSLLSIPDIDKRQDCYDNIILVGSIFKTPGLKEAVLIKLNQDYLVKEPNAIDQSINDPGVNTAILKYQQSTTINDYNEGGSGDNNNSNSNSNSNQVPNSIKLVKYPDYFPEWKKPKEKGGSWHDVYFLGGQIYSKQIYSGSSHHHGKELFVGSDMYEERGPQSIWDASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPV5</accession>
    <name>C4YPV5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPV5"/>
    <dbReference type="PaxDb" id="5476-C4YPV5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02509"/>
    <dbReference type="HOGENOM" id="CLU_169171_0_0_1"/>
    <dbReference type="OMA" id="CWKRQGN"/>
    <dbReference type="OrthoDB" id="5586401at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039870">
        <property type="entry name" value="Coa4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13639">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13639:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="88" mass="10514" checksum="504DBE2A1A65D114" modified="2009-07-28" version="1">MKPEPSTTTETIEEKKEQWEEEAEEEEDDEPDEWDQRIINTGCHKENLKLQLCHADTGDWRQCTKELQAFKECWDKNKNNERTSTVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPX4</accession>
    <name>C4YPX4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA repair protein RAD50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CAWG_02528</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YPX4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02528"/>
    <dbReference type="HOGENOM" id="CLU_006184_0_0_1"/>
    <dbReference type="OMA" id="FSDYYYR"/>
    <dbReference type="OrthoDB" id="18797at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007127">
        <property type="term" value="P:meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000593">
        <property type="entry name" value="DNA repair protein RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001195">
        <property type="entry name" value="DNA repair protein rad50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004584">
        <property type="entry name" value="Rad50_eukaryotes"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00606">
        <property type="entry name" value="rad50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13558">
        <property type="entry name" value="SbcC_Walker_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="14 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005668033" description="DNA repair protein RAD50" evidence="20">
        <location>
            <begin position="24"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="21">
        <location>
            <begin position="31"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="249"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="496"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="609"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="739"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="852"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="999"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="1069"/>
            <end position="1128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EEQ44263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1332" mass="152053" checksum="B694D1810B763B75" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ26</accession>
    <name>C4YQ26_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Jacalin-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ26"/>
    <dbReference type="PaxDb" id="5476-C4YQ26"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02580"/>
    <dbReference type="HOGENOM" id="CLU_009601_2_1_1"/>
    <dbReference type="OMA" id="MFRNNFG"/>
    <dbReference type="OrthoDB" id="74460at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053002">
        <property type="entry name" value="Metalloproteinase_M10B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021917">
        <property type="entry name" value="Unchr_Zn-peptidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054:SF2">
        <property type="entry name" value="MIP04191P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054">
        <property type="entry name" value="ZINC METALLOPROTEINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12044">
        <property type="entry name" value="Metallopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51752">
        <property type="entry name" value="JACALIN_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Jacalin-type lectin" evidence="2">
        <location>
            <begin position="552"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="743" mass="83441" checksum="D0B0FB0F083B4351" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ28</accession>
    <name>C4YQ28_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-3 complex subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_02582</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Adaptor protein complex 3 (AP-3) is a heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ28"/>
    <dbReference type="PaxDb" id="5476-C4YQ28"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02582"/>
    <dbReference type="HOGENOM" id="CLU_001908_1_1_1"/>
    <dbReference type="OMA" id="SGNNWMA"/>
    <dbReference type="OrthoDB" id="10264595at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017105">
        <property type="entry name" value="AP3_complex_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781:SF12">
        <property type="entry name" value="AP-3 COMPLEX SUBUNIT DELTA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781">
        <property type="entry name" value="DELTA ADAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037092">
        <property type="entry name" value="AP3_complex_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="9">
        <location>
            <begin position="53"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="694"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="916"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="985"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1043"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="702"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="759"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="929"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="947"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="992"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1043"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1056"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1086"/>
            <end position="1098"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ44317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1098" mass="125193" checksum="A9C639E638A87DA5" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQG8</accession>
    <name>C4YQG8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor MBP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_02726</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to MCB elements (Mlu I cell cycle box) found in the promoter of most DNA synthesis genes. Transcriptional activation by MBF has an important role in the transition from G1 to S phase. It may have a dual role in that it behaves as an activator of transcription at the G1-S boundary and as a repressor during other stages of the cell cycle.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQG8"/>
    <dbReference type="PaxDb" id="5476-C4YQG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02726"/>
    <dbReference type="HOGENOM" id="CLU_009666_2_0_1"/>
    <dbReference type="OMA" id="ASHNYVL"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000776">
        <property type="entry name" value="Transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000004">
        <property type="entry name" value="Transcription factor MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF15">
        <property type="entry name" value="TRANSCRIPTION FACTOR MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="8">
        <location>
            <begin position="6"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="134"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="246"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="675"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ44457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="852" mass="97435" checksum="A42CAB73F7A786B9" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQP0</accession>
    <name>C4YQP0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_02799</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQP0"/>
    <dbReference type="SMR" id="C4YQP0"/>
    <dbReference type="PaxDb" id="5476-C4YQP0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02799"/>
    <dbReference type="HOGENOM" id="CLU_014831_3_3_1"/>
    <dbReference type="OMA" id="KMLVFRG"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF5">
        <property type="entry name" value="MEIOSIS-SPECIFIC APC_C ACTIVATOR PROTEIN AMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="4">
        <location>
            <begin position="169"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ44529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="510" mass="56383" checksum="4C446B1238BC4975" modified="2009-07-28" version="1">MAISRSLITETSNRFIPSSSSTSVYKTRHKNELQSSYQSHENLDNNIPHANLSIRDDSLFTHSTSSISSNTHFQSSSSSIGSSSAIKRVTLGSTKPSDLHQKIVAEALNFVSSSKVLKFDNKSRSKKIQNRIDAKLVESLTIAEREVSVDAGKSRSTSSIKTIIATDILQAPGLRNDYYSNLVSWSFKTNRVAVGLGSKIYLWGVDNNVTQINHSNEDLVTAVSCSKEYWILVATAGGKIILMDQQSNSVVSEYTNNEGKCIFCFAWFDKSNMFIAGDDFGEVYIFKIHKLFNVQIELVRVFKCHQQQICGLALNGKNDEIAVGANDNCCTIWSIKDFSAPVLKFVLPHNAAIKALCYCPWTVSLLATGGGSKDRKIRFWHTSSGTLLSEYYTDGQITSLIWSRFRKEIVATFGFGGTSKSNLLCVYTYPQMQPILEVNAACNLRILSATLSPDYCSVCVATNDSTIRIYQLWEGSLEILPSATQRIMGAFGSDIIELLEGISKTGDVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQR7</accession>
    <name>C4YQR7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Fatty acid synthase subunit beta</fullName>
            <ecNumber evidence="21">2.3.1.86</ecNumber>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-hydroxyacyl-[acyl-carrier-protein] dehydratase</fullName>
                <ecNumber evidence="21">4.2.1.59</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">Enoyl-[acyl-carrier-protein] reductase [NADH]</fullName>
                <ecNumber evidence="21">1.3.1.9</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">[Acyl-carrier-protein] acetyltransferase</fullName>
                <ecNumber evidence="21">2.3.1.38</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">[Acyl-carrier-protein] malonyltransferase</fullName>
                <ecNumber evidence="21">2.3.1.39</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">S-acyl fatty acid synthase thioesterase</fullName>
                <ecNumber evidence="21">3.1.2.14</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="30" type="ORF">CAWG_04414</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30 31">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20 21">Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 21">
            <text>(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15057"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9924"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78783"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 21">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 21">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 21">
            <text>holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 21">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14 21">[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 21">Belongs to the fungal fatty acid synthetase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.86" evidence="21"/>
    <dbReference type="EC" id="4.2.1.59" evidence="21"/>
    <dbReference type="EC" id="1.3.1.9" evidence="21"/>
    <dbReference type="EC" id="2.3.1.38" evidence="21"/>
    <dbReference type="EC" id="2.3.1.39" evidence="21"/>
    <dbReference type="EC" id="3.1.2.14" evidence="21"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YQR7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04414"/>
    <dbReference type="HOGENOM" id="CLU_000114_5_0_1"/>
    <dbReference type="OMA" id="HFMDNYG"/>
    <dbReference type="OrthoDB" id="5417908at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004313">
        <property type="term" value="F:[acyl-carrier-protein] S-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03447">
        <property type="entry name" value="FAS_MaoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000017">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000078">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.100:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000006">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000015">
        <property type="entry name" value="Fatty acid synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3330:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000003">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="FAS1-like_DH_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016452">
        <property type="entry name" value="Fas1/AflB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013565">
        <property type="entry name" value="Fas1/AflB-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041099">
        <property type="entry name" value="FAS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040883">
        <property type="entry name" value="FAS_meander"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08354">
        <property type="entry name" value="Fas1-AflB-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="FAS1_DH_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22235">
        <property type="entry name" value="FAS1_thioest_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17951">
        <property type="entry name" value="FAS_meander"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17828">
        <property type="entry name" value="FAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005562">
        <property type="entry name" value="FAS_yeast_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 21" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 21" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 21" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 21" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 21" id="KW-0456">Lyase</keyword>
    <keyword evidence="13 21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9 21" id="KW-0520">NAD</keyword>
    <keyword evidence="7 21" id="KW-0521">NADP</keyword>
    <keyword evidence="8 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 21" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Fatty acid synthase subunit beta N-terminal" evidence="28">
        <location>
            <begin position="4"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Starter acyltransferase (SAT)" evidence="27">
        <location>
            <begin position="149"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid synthase beta subunit AflB /Fas1-like central" evidence="25">
        <location>
            <begin position="714"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid synthase meander beta sheet" evidence="29">
        <location>
            <begin position="1118"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1-like dehydratase" evidence="26">
        <location>
            <begin position="1274"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="domain" description="MaoC-like" evidence="24">
        <location>
            <begin position="1507"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="23">
        <location>
            <begin position="1650"/>
            <end position="1918"/>
        </location>
    </feature>
    <feature type="active site" description="For acetyltransferase activity" evidence="22">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="active site" description="For malonyltransferase activity" evidence="22">
        <location>
            <position position="1796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00058855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR005562-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF08354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF16073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF17828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF17951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="EEQ46070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1956" mass="218732" checksum="F4017BE684EFEC7D" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQT7</accession>
    <name>C4YQT7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
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    </organism>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQT7"/>
    <dbReference type="PaxDb" id="5476-C4YQT7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04434"/>
    <dbReference type="HOGENOM" id="CLU_347134_0_0_1"/>
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    <dbReference type="OrthoDB" id="3995760at2759"/>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="380"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="493"/>
            <end position="521"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <begin position="25"/>
            <end position="51"/>
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            <end position="92"/>
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            <end position="329"/>
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            <end position="346"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
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            <end position="729"/>
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            <begin position="730"/>
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    </feature>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Sakthikumar S."/>
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                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
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                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
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                <person name="Kodira C."/>
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                <person name="Logue M.E."/>
                <person name="Martin R."/>
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                <person name="Berriman M."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">WO-1</strain>
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        </subcellularLocation>
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        <location>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQX9</accession>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="8"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="155"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ46132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="414" mass="46684" checksum="F27A4C53255663EE" modified="2010-10-05" version="1">MSSRPKLLSFDAFAKTVEDARIKTTSGGIITLICILITLVLIRNEYVDYTTIITRPELVVDRDINKQLDINLDISFINLPCDLISIDLLDVTGDLSLNIIDSGLKKIRLLKNKQGDVIVNEIEDDEPAFNNDIELSDLAKGLPEGSDENAYCGSCYGALPQDKKQFCCNDCNTVRRAYAEKHWSFYDGENIEQCEKEGYVGRLRERINNNEGCRIKGTTKINRVSGTMDFAPGASFTREGRHFHDLSLYTKYPDKFNFDHIINHLSFGEMPVDGQADELFDSIHPLDDHQFMLHKKAHLVSYYLKVVATRFESLDYKNRIDTNQFSVITHDRPLVGGKDEDHQHTLHARGGIPGVNFNFDISPLKIINRQQYAKTWSGFVLGVISSIAGVLMVGTLLDRSVFAAQQAIKGKKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQY7</accession>
    <name>C4YQY7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQY7"/>
    <dbReference type="PaxDb" id="5476-C4YQY7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04484"/>
    <dbReference type="HOGENOM" id="CLU_090389_14_4_1"/>
    <dbReference type="OMA" id="FFDECSH"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43601">
        <property type="entry name" value="THIOREDOXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43601:SF3">
        <property type="entry name" value="THIOREDOXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="118" mass="13693" checksum="E53E58B49CE4DD6D" modified="2009-07-28" version="1">MLQNIETKPQFSSALQNKNDMIVLDFFDECSHCSDLNDKLDEFSDMYEAQNIRFYKVNIEEDRELAEDYKVSSIPTTLFFKKGKVFDKVVGPEPNEIKKVLDKNLMGWSGRPSQSSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR08</accession>
    <name>C4YR08_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_04506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR08"/>
    <dbReference type="PaxDb" id="5476-C4YR08"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04506"/>
    <dbReference type="HOGENOM" id="CLU_2305703_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="101" mass="11356" checksum="3BFEA0390637D9FD" modified="2009-07-28" version="1" fragment="single">MIRLFPKQIRPLSYLTKTTINPVDFQLKIPEQFTPKSLLVLSTPTNLPQVIEDSIKLSQKQDLQLVVAGVDTVVPYSHRNGVSELWLDEPISIGDSALLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR72</accession>
    <name>C4YR72_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR72"/>
    <dbReference type="PaxDb" id="5476-C4YR72"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04571"/>
    <dbReference type="HOGENOM" id="CLU_2333415_0_0_1"/>
    <dbReference type="OMA" id="VILVHYS"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="98" mass="11320" checksum="E9AB389E9F0382B8" modified="2009-07-28" version="1">MIQIVVTTPPPPKHTDSSSINKNQKYILGCCKPTCIYMGFSSVILVHYSSVVWVYFCNPIKSCSPTRINEIRISQRMGERKRKLRTKKKFVLPILFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR88</accession>
    <name>C4YR88_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04587</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR88"/>
    <dbReference type="PaxDb" id="5476-C4YR88"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04587"/>
    <dbReference type="HOGENOM" id="CLU_037460_0_2_1"/>
    <dbReference type="OMA" id="ATHNYFL"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17871">
        <property type="entry name" value="GPN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000338">
        <property type="entry name" value="GPN-loop GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030231">
        <property type="entry name" value="Gpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF3">
        <property type="entry name" value="GPN-LOOP GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="303"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ46241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="352" mass="40218" checksum="CC3CF0BAAB4C67BE" modified="2009-07-28" version="1">MYGQIVIGPPGSGKSTYCHGMYQFMSAIGRKSCIINLDPANDRLPYPCELDIRDYISLEEIMEELDLGPNGGLMYALESLDKQGIDFFIGKIEQLINEGNYLLFDCPGQVELFTHHNSLYRIFKKLTQLKRLRLCVVSLIDCIYLTSPSQYISILLLSLRSMLQLDLPHVNVISKIDMLKNYGELPFRLDYYTEAQDLQYLTPYLEKESNSVLGQNYVRLTELIGEMVEDFHLVSFEVLSVENKKSMISLMSVIDKANGYSFGSEIGGDTVWSEATRQNGSGNGGYQDVDIHERWIDHKEEYDAEERKQEQAFAEGLPQEEVDNKPLTEDEEWEAALKDWEEKHGGEGAMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRB2</accession>
    <name>C4YRB2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3',5'-cyclic-nucleotide phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_04611</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the cyclic nucleotide phosphodiesterase class-II family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRB2"/>
    <dbReference type="PaxDb" id="5476-C4YRB2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04611"/>
    <dbReference type="HOGENOM" id="CLU_016658_2_1_1"/>
    <dbReference type="OMA" id="ECSYTDA"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047555">
        <property type="term" value="F:3',5'-cyclic-GMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006198">
        <property type="term" value="P:cAMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07735">
        <property type="entry name" value="class_II_PDE_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024225">
        <property type="entry name" value="cAMP-PdiesteraseII_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000396">
        <property type="entry name" value="Pdiesterase2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283:SF1">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02112">
        <property type="entry name" value="PDEase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000962">
        <property type="entry name" value="Cyc_nuc_PDEase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00388">
        <property type="entry name" value="PDIESTERASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00607">
        <property type="entry name" value="PDEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0114">cAMP</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ46265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="47948" checksum="15FB881938C57042" modified="2009-07-28" version="1">MSFEITILGSSGGPLEGSTCSILLKPANISYHDIINDNLPDQVLCIDAGSGMGKLTEIIHQETTTKTSYCNFLQYYPDCETVSYYYHPNVTITTPFSNFQPGRPILHTQNIFNNLQNYLISHSHLDHVCSVVINSAGFNKNMSNKILYGSHYTINAMQQHLFNGKIWPNMPSFKIVNLNYLESNRSERIGIYTVKMFDLSHGEFNKLTEDKEDAQHHSNSNSNSNNIWGKRYDRRRSSITTIPQNTSGLIIKNSEALNHHYLSSAFLITLEVPCTTKEPPPSILVFGDFESDLTSKLSRNLFIWKSIAPLILRNQLKAIVLECSNCKEIAANELYGHLTPKLLIYELKQLAHECKQLDTATTSTEQPLLGLNVIVNHVKEPIADPNQESQLHDPRKRILAELNKLNEIEKLGCNISIALSGTSIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRH1</accession>
    <name>C4YRH1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcription factor spt8 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_04671</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the WD repeat SPT8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRH1"/>
    <dbReference type="PaxDb" id="5476-C4YRH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04671"/>
    <dbReference type="HOGENOM" id="CLU_010934_2_1_1"/>
    <dbReference type="OMA" id="WDRRQPN"/>
    <dbReference type="OrthoDB" id="10260946at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010557">
        <property type="term" value="P:positive regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000925">
        <property type="entry name" value="Transcription factor SPT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057544">
        <property type="entry name" value="Beta-prop_SPT8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23798">
        <property type="entry name" value="Beta-prop_SPT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="11">
        <location>
            <begin position="275"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="431"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="579"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="498"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="49"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="122"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="198"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="516"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="544"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ46324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="769" mass="87228" checksum="967DAE93411CF0AD" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRW8</accession>
    <name>C4YRW8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_04825</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRW8"/>
    <dbReference type="SMR" id="C4YRW8"/>
    <dbReference type="PaxDb" id="5476-C4YRW8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04825"/>
    <dbReference type="HOGENOM" id="CLU_011675_5_0_1"/>
    <dbReference type="OMA" id="EFNNAYR"/>
    <dbReference type="OrthoDB" id="1739076at2759"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000207">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000005">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="11">
        <location>
            <begin position="2"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="10">
        <location>
            <begin position="313"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ46471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="573" mass="64048" checksum="1B0D7D84C88D007C" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRZ9</accession>
    <name>C4YRZ9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA-processing protein EFG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">rRNA-processing protein efg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_04857</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EFG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRZ9"/>
    <dbReference type="SMR" id="C4YRZ9"/>
    <dbReference type="PaxDb" id="5476-C4YRZ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04857"/>
    <dbReference type="HOGENOM" id="CLU_066912_2_0_1"/>
    <dbReference type="OMA" id="KPHRIQE"/>
    <dbReference type="OrthoDB" id="47732at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019310">
        <property type="entry name" value="Efg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050786">
        <property type="entry name" value="EFG1_rRNA-proc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10153">
        <property type="entry name" value="Efg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="206"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ46502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="237" mass="27761" checksum="603037859D91C102" modified="2009-07-28" version="1">MPKTVKNPKNNKSRSRGAPIQVAESIGSGSAKIKKKIRDIERLIKKNPNLPADKKIEYDRALKGLKVELQNSQVQNKAKVLAKKYHMVRFFERKKAVRKLKNLRKEFERISQTGIRKDIKKARKQLRHGEIDLAYVILFPKTEKYISLYPSPNDEDQTDPNVIKGLKITEERRREFRKYIEKLMEEGKLPFSIDDALQGKNIRLDNDKTQKAVLTEEIDAPEQKQDEQQEEQDDFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS46</accession>
    <name>C4YS46_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_04904</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS46"/>
    <dbReference type="PaxDb" id="5476-C4YS46"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04904"/>
    <dbReference type="HOGENOM" id="CLU_033860_2_0_1"/>
    <dbReference type="OMA" id="AENEMFK"/>
    <dbReference type="OrthoDB" id="268763at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="236"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ46549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="458" mass="53337" checksum="83F264F20E9F4687" modified="2009-07-28" version="1">MSREDPIKAEKDFSATLDEQFPLIEKISDYKQALDKYLVLEKQTRQSSDLASSKRVLNKIVTTLVDNNDWEYLNDLITILSKKHGQLKSSIQAFIKDVIDNLDKLDENNKQQLELKMKLIETIRTVTDKKIFVEVERAIVSRQLAKIYLNKLNDLDKAVEILCDLQVEAYSLMPFSDKIEYILEQIQLTLQKGDYGQAKILSRKILLKSLKNFAKADEFKATYLKYLIDINVFDYDYISIVKNLLLLIEIPLIKESAEYKEYLVSVIYYIILSTYDPHQNDLINRIKSNPIFTKNVDANIVKLLDVFTTNELIHWSNIESLYKTSFANSKIFADEKNYKNLQKRIIEHNLRVINKFYQSIRLDRLAQLLQLSVDEAESYVSELVNQAMIVAKINRPQGLVKFDKTKHIEGSDPRTSDNHINAVLNDWCYDIEKLLEEVDAIGHLINKEEMMYGIKQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS88</accession>
    <name>C4YS88_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS88"/>
    <dbReference type="PaxDb" id="5476-C4YS88"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04947"/>
    <dbReference type="HOGENOM" id="CLU_2209698_0_0_1"/>
    <dbReference type="OMA" id="SKWYEAY"/>
    <dbReference type="OrthoDB" id="4024478at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="113" mass="13128" checksum="53521C27710A9624" modified="2009-07-28" version="1">MIPSMTIDQLIESKWYEAYESYSINHNLPIDKTIKSSLPSITQEQQQQQQQQQQEQVPTQTPEIDLTNDIPNIIKLINKQSNVKELSTELTNVLLKYYWAGFDTGYECCNSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSQ5</accession>
    <name>C4YSQ5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_05123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="HOGENOM" id="CLU_063930_2_0_1"/>
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        <property type="component" value="Chromosome 6"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
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        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
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        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="30307" checksum="2B5F838275B5F837" modified="2009-07-28" version="1">MSTTTTRSGTKSKPVKRNSYLSNLRHLTNKDVTKAAYTLLEAFAEDDLAKMLVCHIEDKAERQLCELTLYEAYIRQHIAKGIVIGQGETESGFETVSIWSHPKSEEEGLDSYTNLMEAGYGKVWNVYGEEGRKKVFYGMLPLLHDSCERIINSDSRFKNKNVYTLVYVGSSKQGKGKGNLRKLFEYMFETYIDNDKNSIAYLESSSPANIPIYNRFGFHVAEDIVLGEKCEGAIRGRDYAVMNVMIRGTKGHDWTKDENTFNSKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSZ2</accession>
    <name>C4YSZ2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSZ2"/>
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    <dbReference type="HOGENOM" id="CLU_016174_1_1_1"/>
    <dbReference type="OMA" id="EMYSNTR"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="694" mass="79679" checksum="B18C67BB67755B5E" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT32</accession>
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        <submittedName>
            <fullName evidence="5">Heat shock protein SSC1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_05730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT32"/>
    <dbReference type="PaxDb" id="5476-C4YT32"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05730"/>
    <dbReference type="HOGENOM" id="CLU_005965_2_1_1"/>
    <dbReference type="OMA" id="IFGKEPC"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000003">
        <property type="entry name" value="Heat shock protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="533"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ47168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="638" mass="70583" checksum="DBCB72FED227753A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTC9</accession>
    <name>C4YTC9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcriptional protein SWT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_05416</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SWT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTC9"/>
    <dbReference type="PaxDb" id="5476-C4YTC9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05416"/>
    <dbReference type="HOGENOM" id="CLU_048317_0_0_1"/>
    <dbReference type="OMA" id="WANDWIY"/>
    <dbReference type="OrthoDB" id="2017974at2759"/>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18727">
        <property type="entry name" value="PIN_Swt1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000045">
        <property type="entry name" value="Transcriptional protein swt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049014">
        <property type="entry name" value="SWT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052626">
        <property type="entry name" value="SWT1_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161:SF0">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21693">
        <property type="entry name" value="SWT1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="PIN" evidence="7">
        <location>
            <begin position="106"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00074620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ46870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="451" mass="51485" checksum="D100C68EF4C4B3D7" modified="2009-07-28" version="1">MSLPSKYAPEGLSEEDQLKVITSGERKPRKPIDYKLRTIDDRVQSALHTHPNTSEDIEMIPIEDGKEVDVISEYIEYLRGNSVYEDKNEMVIEESPEFEIVGGNISFLVLDTNFLISHLNIVDTLKNIASEYGLKLIIPVYVVQELDGLKNSNRLHNNSNGKFTGETVSQLAIWANRWIYQALADSSAVVKGQKLSQRISKDLVKDDAIFDCCLYFKKTYPQSLVILLSNDKNLCAKALSNDVLTVSFRENMSGRLIANTIYEENVERFGKLQTKVEPVAPKIQNHVSSEVVEPSNEWVEKTQQIDELTTFEQVSEKVYNEIQMILLAALDHCMVAEYGDDLDLIQGYDKNSVTTIEDCAELIIRFWMTVFSQYFDATPGNFVPFRETGKGRNSRKTPIHIYQPEDSNELRKFVTFWTTVLTVIYDAVMDSTQQTALKWLIARWNKMADTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTJ8</accession>
    <name>C4YTJ8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YTJ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05491"/>
    <dbReference type="HOGENOM" id="CLU_020991_1_0_1"/>
    <dbReference type="OMA" id="EYWIYEN"/>
    <dbReference type="OrthoDB" id="2240312at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000500">
        <property type="term" value="C:RNA polymerase I upstream activating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039601">
        <property type="entry name" value="Rrn5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28079">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28079:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="13"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="718"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="603"/>
            <end position="630"/>
        </location>
    </feature>
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        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
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        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
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        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
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        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
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        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="578"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="656"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="724"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="763" mass="89385" checksum="B7FC3B0EDC95AC78" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YU01</accession>
    <name>C4YU01_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05649"/>
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    <dbReference type="OMA" id="THINEFN"/>
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    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="745" mass="85383" checksum="E9D6F03D988F21B5" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCT8</accession>
    <name>C4YCT8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein GVP36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_00322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_750214_0_0_1"/>
    <dbReference type="OMA" id="LQLEANC"/>
    <dbReference type="OrthoDB" id="5549748at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
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    </dbReference>
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        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018859">
        <property type="entry name" value="BAR_dom-cont"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10455">
        <property type="entry name" value="BAR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ42124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="38453" checksum="4CEECE8AF6FB9A6F" modified="2009-07-28" version="1">MSFKFPSFDFKSIQESLPSVDQVKESFTKTSDQLSKSIQPYTTKTTQLISEQLKHLEQLANNTTDDIDVSELPQDYLQLESNCDLLLKLYTDLIQTTNETYGKVSYDYPPGNYAINKIKDANVSGLIGQKFNQLKNVSSPQELEKVLLGQDVDAESKDESGVVSIQPTSPQLPKTLFGHLAEICAKHSDELKSSEHPLSFALLQVSSTYQEIAVARLDQDKKIMSGLNAELIRTLNESFIKVNELRKKVYATRGEFDLLRSKYEKSDPENEELIAKEDGFVSATEVAVVEMKKLLKPSKNIDLLKVLVAAQKDYFEVGAKKLKELLDNLDKIPTTGEEEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCU3</accession>
    <name>C4YCU3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pet127p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_00327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCU3"/>
    <dbReference type="PaxDb" id="5476-C4YCU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00327"/>
    <dbReference type="HOGENOM" id="CLU_018196_0_0_1"/>
    <dbReference type="OMA" id="CYDERLP"/>
    <dbReference type="OrthoDB" id="10249045at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000964">
        <property type="term" value="P:mitochondrial RNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013943">
        <property type="entry name" value="Pet127"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014:SF0">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08634">
        <property type="entry name" value="Pet127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ42129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="705" mass="82847" checksum="BA296C915329C85F" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCV4</accession>
    <name>C4YCV4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inositol phosphorylceramide synthase regulatory subunit KEI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00338</name>
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    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCV4"/>
    <dbReference type="SMR" id="C4YCV4"/>
    <dbReference type="PaxDb" id="5476-C4YCV4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00338"/>
    <dbReference type="HOGENOM" id="CLU_103819_0_0_1"/>
    <dbReference type="OMA" id="DQPVGFN"/>
    <dbReference type="OrthoDB" id="3338076at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070917">
        <property type="term" value="F:inositol phosphoceramide synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006673">
        <property type="term" value="P:inositol phosphoceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013862">
        <property type="entry name" value="Kei1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08552">
        <property type="entry name" value="Kei1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="26025" checksum="75D5A1F38292234C" modified="2009-07-28" version="1">MTLPTYVNHLLPLKFLGVIPLFIGVEVILGITILNKASGVYGILSLFTGHPINFWQWLYNSLAIITLPVYVSALINLKTKPRNLRKISLATIVYVLDTFIGSLYTLYFIYFWFSSEEGSIKSTGADSSSSTLSSQSASAARELFITLGTTISVTFIRLYFTLVILSFAKALLKQNRMETRYNDVQNGTSSRSLEQEEEDEVANATGYFGEFRKAIFDLEVRSKEYLDDLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCV5</accession>
    <name>C4YCV5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 19">Serine/threonine-protein kinase RIO1</fullName>
            <ecNumber evidence="4 19">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">CAWG_00339</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4 19"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCV5"/>
    <dbReference type="PaxDb" id="5476-C4YCV5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00339"/>
    <dbReference type="HOGENOM" id="CLU_018693_4_1_1"/>
    <dbReference type="OMA" id="HPMSLDF"/>
    <dbReference type="OrthoDB" id="205248at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05147">
        <property type="entry name" value="RIO1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000755">
        <property type="entry name" value="Homoserine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000403">
        <property type="entry name" value="Serine/threonine-protein kinase RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017407">
        <property type="entry name" value="Ser/Thr_kinase_Rio1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038147">
        <property type="entry name" value="Ser/Thr_PK_RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 19 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 19 25" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 19 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 19" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="24">
        <location>
            <begin position="71"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="385"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="402"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="434"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="20">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="20">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="EEQ42141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="493" mass="57318" checksum="AADAAEA2B2BACDB2" modified="2009-07-28" version="1">MSSEEILQGVEDIHLNTSSDSDSEYELEEETTTKSLPSSSRTITEKEDIVTKYADKIKTDPIKKGPKITKDRANRATVEQVLDPRTLRFLAKIINKGIISRINGCISTGKEANVYHGTIDDPDNDREYAVKIYKTSILVFKDRERYVDGEFRFRNTKNQSNPRKMVKVWAEKEFRNLKRIYQNGIPCPEPIELKSHVLVMEYLTKGDGQPSPKLKDYPFKDVQDIVNYYHKMLFYMRRLYQECRLVHADLSEYNSIVHKDNLYIIDVSQSVEPEHPMALDFLRMDIKNVNDFFSRSKINVYPERLIFRFITSEGHLLGIADNSDQELEKYLETLPLKTEDDQEVEDEIFRSLHLVRSLNNLDERDFQKFSEGKVDTMKDLVAMKEGEVASPGLQTANGNEVDSSEDEDNEGVSEEEEESSSEDDDDEEEEVDGISEKEWVEREQNAPRGKKYEDKDEKKARKEAAKLAKQEKRKTKMKKHIKKKIINKRKTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCX0</accession>
    <name>C4YCX0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division control protein 48</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_00354</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCX0"/>
    <dbReference type="SMR" id="C4YCX0"/>
    <dbReference type="PaxDb" id="5476-C4YCX0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00354"/>
    <dbReference type="HOGENOM" id="CLU_000688_12_3_1"/>
    <dbReference type="OMA" id="VWPAYPE"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19528">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000004">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000001">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000003">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000048">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="7">
        <location>
            <begin position="36"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="6">
        <location>
            <begin position="136"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="248"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="521"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="795"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="797"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ42156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="826" mass="90991" checksum="E3305EA8969FA3C6" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD17</accession>
    <name>C4YD17_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_00405</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMP52 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD17"/>
    <dbReference type="PaxDb" id="5476-C4YD17"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00405"/>
    <dbReference type="HOGENOM" id="CLU_071330_2_2_1"/>
    <dbReference type="OMA" id="CIENAKA"/>
    <dbReference type="OrthoDB" id="430436at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051170">
        <property type="term" value="P:import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000366">
        <property type="entry name" value="Protein FMP52, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014843">
        <property type="entry name" value="Him1/Fmp52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF7">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08732">
        <property type="entry name" value="HIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ42203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="24247" checksum="634C90EAFC642E26" modified="2009-07-28" version="1">MSTFILGATGLVGSQIVKAAESSPAIKSITTLTRRTPDFANSSSKLKTLEESDSSKWSEIIKSQAVSSDVYLSAFGTTRAKAGSAENFKKIDYGINYSSAKAAKENGSKVCVLVSSMGANASSPFLYMKTKGELEDDIIKLGFDHTVILRPGALLGERKESHGLGNSIAQTIGNWTKGTWLQGLLKPIDASDVGKVAIDFAQKGINGELKDKVIIVGGDDLVKLANSLN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-31" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD57</accession>
    <name>STS1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>Tethering factor for nuclear proteasome STS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">STS1</name>
        <name type="ORF">CAWG_00447</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cut8/STS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD57"/>
    <dbReference type="SMR" id="C4YD57"/>
    <dbReference type="PaxDb" id="5476-C4YD57"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00447"/>
    <dbReference type="HOGENOM" id="CLU_054606_2_0_1"/>
    <dbReference type="OMA" id="DYTPHFL"/>
    <dbReference type="OrthoDB" id="10061064at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031144">
        <property type="term" value="P:proteasome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1590:FF:000005">
        <property type="entry name" value="Tethering factor for nuclear proteasome STS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1590">
        <property type="entry name" value="Tethering factor for nuclear proteasome Cut8/Sts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013868">
        <property type="entry name" value="Cut8/Sts1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038422">
        <property type="entry name" value="Cut8/Sts1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032:SF1">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08559">
        <property type="entry name" value="Cut8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000409402" description="Tethering factor for nuclear proteasome STS1">
        <location>
            <begin position="1"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="327" mass="37321" checksum="564D9CF23844BFCD" modified="2010-10-05" version="1">MMSTNFQWPGTNKNDNTEVSVETPSSTDPHVPRYPFTAMSHATASTTMKKRKRDDFDGDKSTTITMNTTTTRKYIQSSLGSSKFKKAKTPKISGQPLPLPRLIESLDKSNLQKLVQDLITVHPELQSTLIKISPRPSIQDSIQLLQDKFDMIISHLPYKCDVESDYSYLRIKPHLQEFLSSVSDFILNYLPPLETNMTHSLQFLHETTKLVYNLPNFTNQEFQYTKSSALEQIANCWLIVLSQDEEKEGNTDVVKVIQELELLEKLHEHNEISFNKFEKVVDYCKDKLEQHELIMNNNEAGSGVTSSISDLITVDYSKYSIANTTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD60</accession>
    <name>C4YD60_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD60"/>
    <dbReference type="PaxDb" id="5476-C4YD60"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00450"/>
    <dbReference type="HOGENOM" id="CLU_1740259_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="150" mass="15983" checksum="317488EE88BC5CF0" modified="2010-10-05" version="1">MNARTTLPSISSSQSCNGGKSGIKSKASPINFLLATYPPNCCLIVSNVDDFVPICLSTTDPHLSFKFPNIHWKISSCNHSISCNGSYPLVALPSASVVPSASTICIKQSASVKSLKNLFPNPSPKWAFGTNPATSNNIIGTPLFPLRQYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDF6</accession>
    <name>C4YDF6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_00550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDF6"/>
    <dbReference type="PaxDb" id="5476-C4YDF6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00550"/>
    <dbReference type="HOGENOM" id="CLU_715708_0_0_1"/>
    <dbReference type="OMA" id="YERIVWR"/>
    <dbReference type="OrthoDB" id="4005225at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ42342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="349" mass="40835" checksum="5058372EE01D72F3" modified="2009-07-28" version="1">MLNVRPPKSDMTSSSLKSATRFFWTSTIRSKNRKQENISLAAALNLLVKPTEPTKTYKPSLYDSLTKGSVEEQFNKVPIHVPIANDHVSDKFISNILHGIKSSNVSTNHRGVNYSQLYEMNRVDLSAFIANVDSQEILFDIMETFQNHNKLTPRVLTDIILNRRFHDLDKSPIDLIDLKQSTNFQDLDVYKIQIVLLKKYHDLKQPLNIVKNLKHNFDSIYLPLIETRKLTPFYEKIIWHFTFDYLNQFKEPHYIETLNNLRTSFLIWETTKKRKSTQISQEILNFHTNLNDLQKLFLETASSVEDPTHISSLRKLSMKYRIYELHPEDAKSESFKKEFGDLVLTLNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDR8</accession>
    <name>C4YDR8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_00665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDR8"/>
    <dbReference type="PaxDb" id="5476-C4YDR8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00665"/>
    <dbReference type="HOGENOM" id="CLU_1348753_0_0_1"/>
    <dbReference type="OMA" id="SEAICCP"/>
    <dbReference type="OrthoDB" id="207120at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46026">
        <property type="entry name" value="RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46026:SF1">
        <property type="entry name" value="RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="53"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ42454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="203" mass="22678" checksum="F8B094BCDC366C5F" modified="2009-07-28" version="1">MKVKAIFDYKSDYDEDLSFDAGTIINIISVENDEWYSGEYDGKQGMFPKNFVEELKEPTTAESSGNSDQPAIPEEPKPAQPLKVETDNNDGGSNNAPVETTSPKKSIEKPLRSPTETVHSASKAIESHSSKIPMPQSFSSKPVDPYSIKKQFVGARASSYVPKIQPRDDSYLVARPLHILRHHLLLVMMIRWKSSKKKSPSCH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-04-05" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDV1</accession>
    <name>GSM1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>Glucose starvation modulator protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">GSM1</name>
        <name type="ORF">CAWG_00699</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcription factor which regulates nonfermentable carbon utilization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ERT1/acuK family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDV1"/>
    <dbReference type="PaxDb" id="5476-C4YDV1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00699"/>
    <dbReference type="HOGENOM" id="CLU_010748_2_2_1"/>
    <dbReference type="OMA" id="FCHEKHL"/>
    <dbReference type="OrthoDB" id="2538135at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF8">
        <property type="entry name" value="GLUCOSE STARVATION MODULATOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000406480" description="Glucose starvation modulator protein 1">
        <location>
            <begin position="1"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="566" mass="63561" checksum="3C3BD192FE0FF976" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDW3</accession>
    <name>C4YDW3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_00711</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDW3"/>
    <dbReference type="PaxDb" id="5476-C4YDW3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00711"/>
    <dbReference type="HOGENOM" id="CLU_001666_8_2_1"/>
    <dbReference type="OMA" id="TIIHGPP"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004483">
        <property type="entry name" value="SMUBP-2/Hcs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048761">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00376">
        <property type="entry name" value="IGHMBP2 family helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21138">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="236"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ42499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="719" mass="80505" checksum="2BBF75C25A4E791F" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YE06</accession>
    <name>C4YE06_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_00756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YE06"/>
    <dbReference type="PaxDb" id="5476-C4YE06"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00756"/>
    <dbReference type="HOGENOM" id="CLU_665828_0_0_1"/>
    <dbReference type="OMA" id="MKVIIVR"/>
    <dbReference type="OrthoDB" id="1932312at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016520">
        <property type="entry name" value="UCP007778"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007778">
        <property type="entry name" value="UCP007778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ42542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="437" mass="49930" checksum="D0BAE3237B7AECAB" modified="2009-07-28" version="1">MSKQTTHIHKLIADYLKENNYLETLKQFENEHGNPIPATKLLDESLSDIINDRIQYNTLLDDNKTNEGVINVNDELAPELKVIITQQFSNWITPFPHQPSKLIDIDGLVISSCHDKKNELIYLSSNDCKVYVIKQNRILHTLKMPVVIKKILTIDNSDKVVLVGMNGILYLRKRGTLEEIDQFQAHKRLIVDAKSITFQNRNYLITLGWDFHLRLILLNENNTDQNEVQRFEILSELKLKQQGSCLDVTVYQDQLVIILGKTENTLLDVITMSGKDSRELTLVHKISLNDAEFTAAGFSPRCLMIENSGHVPLIAVGTSHEPYMRLIIVPLQDLANEPSIKRNQIIKNLNTMSPQDRYSQPIIAWRLQKSDNNKASGVWVMGDDGTIRGIDIVEDQVIVELKDGHQGKIKDFITFIDEDSVEKLITSGIDREIVTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YE25</accession>
    <name>C4YE25_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Serine/threonine protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_00775</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YE25"/>
    <dbReference type="PaxDb" id="5476-C4YE25"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00775"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_5_1"/>
    <dbReference type="OMA" id="IFRKIDW"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000048">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="163"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="9">
        <location>
            <begin position="450"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="52"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ42561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="64710" checksum="6CE5F4E019090418" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEB6</accession>
    <name>C4YEB6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_00871</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34935"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEB6"/>
    <dbReference type="PaxDb" id="5476-C4YEB6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00871"/>
    <dbReference type="HOGENOM" id="CLU_015515_1_0_1"/>
    <dbReference type="OMA" id="MEMQYFV"/>
    <dbReference type="OrthoDB" id="57698at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00858">
        <property type="entry name" value="GlyRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.200:FF:000001">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.230:FF:000002">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="171"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEQ42652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="652" mass="73688" checksum="1B9C82C04A1AF6CE" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YED1</accession>
    <name>C4YED1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_00888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YED1"/>
    <dbReference type="PaxDb" id="5476-C4YED1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00888"/>
    <dbReference type="HOGENOM" id="CLU_048479_1_1_1"/>
    <dbReference type="OMA" id="DLYGCHG"/>
    <dbReference type="OrthoDB" id="4347at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055323">
        <property type="entry name" value="C57A10.07/YOR238W"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ42667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="31013" checksum="C3EA8ACBC7725AE6" modified="2009-07-28" version="1">MTKTSHLIILPCHSIWKSGPNLGETRDEWHLVDFQIEGYDHLAFKQQILTSLQQLQQDPESYLIISGGETKLDAGPISESLSYYLLASKLCQNDSSILSRVSTEVFARDSFENVIFSICRYYELFAMYPEKITIVGFEFKRERFVKHHLQQALLFPENRINYIGNSPDPKDLDELEIEKYFQELNESEFKYAVKHFQNDWYGLSGSLLKKKIARNPFNRYHGYSESNPKLADFLRAIKDDITTTTTSTTRSNENIRDLLLDMVWVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEE8</accession>
    <name>C4YEE8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_00905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEE8"/>
    <dbReference type="SMR" id="C4YEE8"/>
    <dbReference type="PaxDb" id="5476-C4YEE8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00905"/>
    <dbReference type="HOGENOM" id="CLU_049344_4_1_1"/>
    <dbReference type="OMA" id="ILIWNME"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="60"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ42684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="319" mass="36687" checksum="D7B0D0A671469F6D" modified="2010-10-05" version="1">MSTKSANSTAVNSFNANHSNYDVFRPSFTPVLVNTFLVHLGLATKNPDDTFTFDISKHILEIAAGTGKFTRNLVDNGWTDNLAVLEPSKGMLETFNKNFPQIKNQILGSSYKIPLEDNSIDAVIIAQGFHWFADLDSLKEIYRVLKPQGKLGLIWNFDYASPSQDSSVADSEYFNAGTQYYNTLNFNLDTNEKVFEQYFDNQQWNKAATKFIYGFDVNVPQYRHGKWRQVLKDNPYFSSEEINLFALYDLTVAKDDAWKYWETRSYITEKSDDEKQRIKKDFNELVEKNLDDSSYSDKDKQLIIKPMATHAVVLQKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEI5</accession>
    <name>C4YEI5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Negative regulator of the PHO system</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Serine/threonine-protein kinase PHO85</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_00942</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">When phosphate concentrations are high it phosphorylates the PHO4 transcription factor thus establishing repression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with a number of cyclins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEI5"/>
    <dbReference type="PaxDb" id="5476-C4YEI5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00942"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OMA" id="NWQIFVP"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000062">
        <property type="entry name" value="PHO system negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000410">
        <property type="entry name" value="Probable PHO85-cyclin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF46">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="8"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="300"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ42721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="328" mass="37627" checksum="221D16928566DA39" modified="2009-07-28" version="1">MTGSSSQFQQLEKLGEGTYATVYKGRNRATGALVALKEISLDSEEGTPSTAIREISLMKELDHENIVTLYDVIHTENKLTLVFEYMDKDLKKYMEVHGQQSALDLKVVKSFMFQLLKGIMFCHDNRVLHRDLKPQNLLINNKGELKLGDFGLARAFGIPFNTFSNEVVTLWYRAPDVLLGSRAYTTSIDIWSAGCIFAEMCTGKPLFPGTANEDQLIKIFRLMGTPNERTWPGISQYTNYKNNWQIFVPQDLRLIVPNLDSMGLNLLQSLLQMRPESRITARQALQHPWFHEITMPNAVPQHLSDPYQQQQQQQQQQHPHQPIIDQQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEK9</accession>
    <name>C4YEK9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HRQ family protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_00966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEK9"/>
    <dbReference type="PaxDb" id="5476-C4YEK9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00966"/>
    <dbReference type="HOGENOM" id="CLU_025462_0_2_1"/>
    <dbReference type="OMA" id="TMGIRNM"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ42745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="47814" checksum="31EED2C123F81755" modified="2010-10-05" version="1">MNVTIEESGILRSLGVNNLILLSIPIAAILVYLSYLQKPKPKVNSNKNTNTNTNTSKDHKIADRPLGYWKPDYSFKTPTPPPFPNWDFEKTRPIPYRAFRHKYNVTMGIRSMNWDSWIELDNEWKFYHDLKLKRLQEKESELSGMSDLAQDASWELLQELCQYLPARYPTMFKFENGIMNIIPTGEKYDLKDKSNLNPIVTAAKLVQDDLAIMIEKEDGSYYLESGCICLAGFWRLKDKFGMKLDDIHKSGDVPQYDKQLKSGMNKFFRRLTVNSPVVRNNYFIQTDNNLDWSVSIGSENEEKIGWYTADESDDVNKLYFRSERQSLRRLPISGAIVFTIRTYFLPVTQLCEEPYIPRRLLNGIQSWSEDVGEYKGFHIFKDALLPYLEKKALEQEANGLDPTKEPQVYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFK9</accession>
    <name>C4YFK9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein MGR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_01327</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFK9"/>
    <dbReference type="PaxDb" id="5476-C4YFK9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01327"/>
    <dbReference type="HOGENOM" id="CLU_142435_0_0_1"/>
    <dbReference type="OMA" id="SCWDRVK"/>
    <dbReference type="OrthoDB" id="5409308at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018450">
        <property type="entry name" value="Romo1/Mgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525:SF1">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10247">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01378">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ43090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11537" checksum="E42925C893ED19EC" modified="2010-10-05" version="1">MPPVQQYQYAGHQPSNWDKFKMGAIMGSTVGVCVGVLFGGFSILQNGAGPNGVMRTLGQYIMGSVGTFGLFMSIGSVIRSESGFQNYEKSMVAMQRAKLRAIYRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFM9</accession>
    <name>C4YFM9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60S ribosomal protein L16-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_01347</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFM9"/>
    <dbReference type="SMR" id="C4YFM9"/>
    <dbReference type="PaxDb" id="5476-C4YFM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01347"/>
    <dbReference type="HOGENOM" id="CLU_076922_0_0_1"/>
    <dbReference type="OMA" id="TRFNKTH"/>
    <dbReference type="OrthoDB" id="1882297at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4280:FF:000001">
        <property type="entry name" value="60S ribosomal protein L16-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_uL13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="200" mass="22636" checksum="E3D477A0DD487E71" modified="2010-10-05" version="1">MSSFEKVVVIDGKGHLLGRLASIVSKQILNGQKVVVVRCEELNISGEFFRNKLKYHDYLRKATRYNKKKGPFHFRAPSRILYKAIRGMIPHKTARGKAALERLKVFEGVPPPYDKKKRVVVPQALRVLRLKPGRKYTTVGKLSSAVGWKYESVVEKLEEKRKVQSAEYYAKKKALTKKLNAAKASTAESEAAQKLAAFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFQ1</accession>
    <name>C4YFQ1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kynurenine formamidase</fullName>
            <shortName evidence="3">KFA</shortName>
            <shortName evidence="3">KFase</shortName>
            <ecNumber evidence="3">3.5.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Arylformamidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">N-formylkynurenine formamidase</fullName>
            <shortName evidence="3">FKF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BNA7</name>
        <name evidence="5" type="ORF">CAWG_00027</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13009"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
            <dbReference type="EC" id="3.5.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the kynurenine formamidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFQ1"/>
    <dbReference type="SMR" id="C4YFQ1"/>
    <dbReference type="ESTHER" id="canal-bna7">
        <property type="family name" value="Kynurenine-formamidase"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YFQ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00027"/>
    <dbReference type="HOGENOM" id="CLU_016852_1_0_1"/>
    <dbReference type="OMA" id="DHYDIMK"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="UniPathway" id="UPA00333">
        <property type="reaction ID" value="UER00454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03014">
        <property type="entry name" value="KFase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027519">
        <property type="entry name" value="KFase_ver/fungi-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0823">Tryptophan catabolism</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="4">
        <location>
            <begin position="26"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HGGXW" evidence="3">
        <location>
            <begin position="37"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ41840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="267" mass="30609" checksum="4E1B92AE06554649" modified="2009-07-28" version="1">MEDISEEQEFKYGEHSLQKIKVFKYSSTNASTYIYIHGGAWRDPSNTFDEMRPVLGIPNANLIGINYRLSPEIKHPEHLIDILRALRFVKQNFDVSQITLLGHSVGATMILQLLHYRQIIRDGLKHTHKDDLSSLDNLFAYVNDNVLLSQVIFLDGIYDVVELLKEYPDYASFVDDAFVSNKHFADSTQLSSANESLDLPFSLVSKDTKFLIYQSLEDDLLSMKQTHLLIDYLSSKNQGFTLHVGNWGKHEEIFGKYREIVFSGNVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFX6</accession>
    <name>C4YFX6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ran-specific GTPase-activating protein 30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_00087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFX6"/>
    <dbReference type="PaxDb" id="5476-C4YFX6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00087"/>
    <dbReference type="HOGENOM" id="CLU_014536_0_0_1"/>
    <dbReference type="OMA" id="QSMFFTA"/>
    <dbReference type="OrthoDB" id="512915at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008812">
        <property type="entry name" value="Ran_GTP-bd-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31010:SF2">
        <property type="entry name" value="RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31010">
        <property type="entry name" value="RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN 30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05508">
        <property type="entry name" value="Ran-binding"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ41900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="50135" checksum="AFCE08116C4FC2E8" modified="2009-07-28" version="1">MDQILLKASNQAVSFAIRSGISLASGYAIKTISTFLDKIPESSKLHQKIIIKQKKLKSKIDIITITIDLIKLAAIKGGGNGNGNSGGNTILQNSLQLINDLQIQFNEFDNNINELIKNLSGNNEKESIKQVESYMNSLLDDINEAIPILNLVLVTSGVNFNGNVNIHGISPGRLLQAANYINNSSGGDNDDDNDNSTIGPVFDLVTYSIFYNPSRLKYIDGEIDELACINWKETYARSSVSIKKLKDYHYQLTIIEDFNDGRYHDDEDDKENKPGEMVIDLNSVQSMFFTASGKLLRLEERSSPVLIIKILKNGVEEWIALGELNQGEFDDDEDEDSQDEDTKKFVNKINAKLIKNSSLSLLEYLIRLCRLQEIECKSILEIPDEILSFYLHDKVNDLSDSGYLPKSLSQRQKDELKKINKENTMTMDSNINRLKNLDIKEPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG22</accession>
    <name>C4YG22_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mon2p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_00137</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YG22"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00137"/>
    <dbReference type="HOGENOM" id="CLU_001169_1_0_1"/>
    <dbReference type="OMA" id="AWRLCLN"/>
    <dbReference type="OrthoDB" id="294853at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="4">
        <location>
            <begin position="199"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="5">
        <location>
            <begin position="940"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="590"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="593"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ41946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1634" mass="187205" checksum="1D632E7344E51EC7" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG88</accession>
    <name>C4YG88_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase subunit K, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_00209</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YG88"/>
    <dbReference type="PaxDb" id="5476-C4YG88"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00209"/>
    <dbReference type="HOGENOM" id="CLU_172736_1_2_1"/>
    <dbReference type="OMA" id="FQPHQLA"/>
    <dbReference type="OrthoDB" id="2094445at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021278">
        <property type="entry name" value="ATP19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11022">
        <property type="entry name" value="ATP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ42012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7422" checksum="F8973872BB6A0C97" modified="2009-07-28" version="1">MGAAYQIFGKTFQPHQLALATLGSVVLLVLPKPWGLPSPTTPPIKASSPEEEKFIQEWLAKHTEEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGK9</accession>
    <name>C4YGK9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sorbose reductase SOU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_03188</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGK9"/>
    <dbReference type="PaxDb" id="5476-C4YGK9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03188"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OMA" id="VAITYER"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05352">
        <property type="entry name" value="MDH-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF13">
        <property type="entry name" value="L-XYLULOSE REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ44891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="30131" checksum="4F8563684102B2DE" modified="2009-07-28" version="1">MSEEIISFTNPALGPLPTKAPQLPSNVLDLFSLKGKVASVTGSSGGIGWAVAEAFAQAGADVAIWYNSKPADAKAEYLTKTYGVKSKAYKCNVTDFQDVEKVVKQIEKDFGTIDIFVANAGVAWTDGPEIDVQGYDQWKKIVDCDLNGVYYCAHTVGQIFKKNKSGSLIITSSMSGTIVNIPQLQAPYNAAKAACTHLAKSLSVEWASFGARVNSISPGYILTDIADFADPEMKKKWWQLTPLGREGLPQELVGAYLYLASNASTYTTGSNIAVDGGYTCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGT4</accession>
    <name>C4YGT4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_03266</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGT4"/>
    <dbReference type="PaxDb" id="5476-C4YGT4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03266"/>
    <dbReference type="HOGENOM" id="CLU_017584_0_5_1"/>
    <dbReference type="OMA" id="YAPANND"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008793">
        <property type="term" value="F:aromatic-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000291">
        <property type="entry name" value="Aromatic amino acid aminotransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF2">
        <property type="entry name" value="AROMATIC AMINO ACID AMINOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="129"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ44966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="523" mass="58806" checksum="7201D02548DA0BA5" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH34</accession>
    <name>C4YH34_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAWG_03375</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YH34"/>
    <dbReference type="SMR" id="C4YH34"/>
    <dbReference type="PaxDb" id="5476-C4YH34"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03375"/>
    <dbReference type="HOGENOM" id="CLU_010365_4_0_1"/>
    <dbReference type="OMA" id="WMDEVLR"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000122">
        <property type="entry name" value="Repressed by TUP1 protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946471" description="ferric-chelate reductase (NADPH)" evidence="18">
        <location>
            <begin position="21"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="19">
        <location>
            <begin position="408"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="605"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEQ45066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="706" mass="80997" checksum="D19B4FBD6763E5D0" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH88</accession>
    <name>C4YH88_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sorting nexin-41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_03432</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YH88"/>
    <dbReference type="PaxDb" id="5476-C4YH88"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03432"/>
    <dbReference type="HOGENOM" id="CLU_748017_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051079">
        <property type="entry name" value="Sorting_Nexin_Autophagy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979:SF2">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="9">
        <location>
            <begin position="172"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ45120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="370" mass="40806" checksum="623FD6EBB959FA13" modified="2009-07-28" version="1">MSSVLRNQDNPPTISEVSSTTKENTDNSNSKQEEKEKEKEKEKEKEKEISSTIENPTFVDDEEDNNPFSHHGEGLTSFMTANSFNEGSNTKSDKGTTKENNNSSSNNNRGDNNDDDDDDSLLLYNTSNNNKSNNVSRVNPMLKSTGEVFKTVNMNFESRVTKLLKPNTKIRIQITEAGNSNEGMSNSSKKYTVYTIKLINLEDPNNDILTRRRYSDFESLRDVLTKIFPLIVIPPIPPKNYFDFSMLNGLVGSNHENSSLSVAGSNGNSGGSGGGGAGGGAGSGSGSGSIITSPKTYSYINSTHLTKGKLIEHRKRLLTNFLNNCLEIKQIRSLEFFAKFLDPNANWGDEIALIQSQLPKSIYLSNPLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHC3</accession>
    <name>C4YHC3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secretory component protein SHR3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_03469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHC3"/>
    <dbReference type="PaxDb" id="5476-C4YHC3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03469"/>
    <dbReference type="HOGENOM" id="CLU_080510_1_0_1"/>
    <dbReference type="OMA" id="ANMLFDG"/>
    <dbReference type="OrthoDB" id="5229808at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013248">
        <property type="entry name" value="Psh3/Shr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228:SF1">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08229">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029187">
        <property type="entry name" value="Shr3_AAP_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00786">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ45155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="26217" checksum="D9BC9500F53FCDE1" modified="2010-10-05" version="1">MMAYKDIVPIGTSLIIGSTCFGLGIIYGNWPYDLNTLWIHDIPEAFDASLRHYQQWGNSPMYVHYTLHAVGLLGLIGHFIKLYKPDEDAKYFEYGSLGLFMVGVVIYLTNLRTGVNSCLVGQWGDVDYQTGINVMAASQVMIIFVLLGVLLLQGGLYYAQWYDNKLKEEFYRQEAKEAALAAESQAQQEHDIATKGKKDKAQPQGEVIEEVTGATTTTGAASATKGQKKTTKKRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHC6</accession>
    <name>C4YHC6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar transporter chaperone complex subunit 4</fullName>
            <ecNumber evidence="3">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Polyphosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">SPX-dependent polyphosphate polymerase VTC subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Vacuolar membrane polyphosphate polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_03472</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19574"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the VTC4 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="3"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHC6"/>
    <dbReference type="SMR" id="C4YHC6"/>
    <dbReference type="PaxDb" id="5476-C4YHC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03472"/>
    <dbReference type="HOGENOM" id="CLU_009308_0_0_1"/>
    <dbReference type="OMA" id="NVNAYMR"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07751">
        <property type="entry name" value="PolyPPase_VTC4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.30:FF:000001">
        <property type="entry name" value="Vacuolar transporter chaperone 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="623"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="649"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="689"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="16">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ45158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="709" mass="82346" checksum="4244AD5A6EDB9E94" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHD4</accession>
    <name>C4YHD4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_03480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHD4"/>
    <dbReference type="SMR" id="C4YHD4"/>
    <dbReference type="PaxDb" id="5476-C4YHD4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03480"/>
    <dbReference type="HOGENOM" id="CLU_676136_0_0_1"/>
    <dbReference type="OMA" id="MEPKMAL"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="4"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ45166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="407" mass="44874" checksum="D29A3856E888242F" modified="2010-10-05" version="1">MTSKVVIIGGSYAGLAALNTLKSLITKNSGAIAKSISITLIEPKSGFLNILGLPKSIVNKEFASQQYVPFCNFLKFDNVVSNSNDLKVQLKENTNSDNNNLMLNYIQGKVTKLTSSRVTYTTNDTDESSIDYDYAILATGRNRNWPVNPKGITFESYLNEMEITNKKIQKSSIISIIGGGAVGIELAAEIKLHYPNKVVNLIHPHGTLPPEPISDAFKNKTLQSLKQANINVFLNTRIDTSKTSLNNGETSNLKTTDGKTIESNLNIWATSFKNNLDYLSLDLQRSIHITANHNIKTNDYLQVSNMSNIYAVGDLIELSTIKSAGWAFHTGIQAGTNVYNSIFDKPLQLSRISFKQIDSHKLTIVGGEGSIIHEVKGNLEINPESMVQEYQDYRLGTCKKFIGATVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHF1</accession>
    <name>C4YHF1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dynamin GTPase</fullName>
            <ecNumber evidence="3">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CAWG_03497</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="3"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHF1"/>
    <dbReference type="SMR" id="C4YHF1"/>
    <dbReference type="PaxDb" id="5476-C4YHF1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03497"/>
    <dbReference type="HOGENOM" id="CLU_008640_0_1_1"/>
    <dbReference type="OMA" id="PLKMGYV"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="PHI-base" id="PHI:8496"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000741">
        <property type="entry name" value="Putative mitochondrial dynamin GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056495">
        <property type="entry name" value="LIS_MGM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24550">
        <property type="entry name" value="LIS_MGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
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    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="217"/>
            <end position="494"/>
        </location>
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            <end position="879"/>
        </location>
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            <begin position="115"/>
            <end position="191"/>
        </location>
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            <begin position="115"/>
            <end position="139"/>
        </location>
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            <begin position="140"/>
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        </location>
    </feature>
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            <begin position="156"/>
            <end position="191"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EEQ45183.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="897" mass="99944" checksum="2EF71C29331A1CEA" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHJ9</accession>
    <name>C4YHJ9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_03546</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
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                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
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                <person name="Lorenz M.C."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">WO-1</strain>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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        <property type="entry name" value="PROLINE UTILIZATION TRANS-ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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        </location>
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        </location>
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        </location>
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        </location>
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            <end position="911"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ45231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="944" mass="108282" checksum="04C31683B9707C7B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHU6</accession>
    <name>C4YHU6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="HOGENOM" id="CLU_2263357_0_0_1"/>
    <dbReference type="OMA" id="PIDRTDT"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944234" evidence="1">
        <location>
            <begin position="26"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="103" mass="11129" checksum="56C4EDEAF3505DD6" modified="2009-07-28" version="1">MQFTTNLLLSSLLLATLFLSDFVNGSKNYRHIKRNVVTVVNGPIDRTDTYDGPIPTGITTSFHSSSLTTKTMHNSTSGHNDSNHLGVVVDAPIMVIMGLVLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI17</accession>
    <name>C4YI17_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_03724</name>
    </gene>
    <organism evidence="9 10">
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        <name type="common">Yeast</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIF1"/>
    <dbReference type="PaxDb" id="5476-C4YIF1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04224"/>
    <dbReference type="HOGENOM" id="CLU_063901_1_0_1"/>
    <dbReference type="OMA" id="ADFRVHH"/>
    <dbReference type="OrthoDB" id="10251727at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="358" mass="40505" checksum="F83EC3DC87360F58" modified="2009-07-28" version="1">MKSSEFILGETAYKNAKKSLQSLIKQYNNQPETINTPPPPADDDDDDETSTPIPTNNQGMAIHLVISIKIPLSRKKDYIPRIIPISYKLDDVTNKSILLITKDPSTPYRSKLMIKDSPTEDLFSDIISFKKLKSMINKTSTSSTNNKGKKQNLIKIFKNYDIIVCDHRIMKFLPNVLGELFYYKNKKLPFLIQMAKPILLETSKLKAQLKAKSNNNNNNNQQGPSILDGLTISKENKIKDERCDPKYINLQIKSIVKNTNYLPSNVINKGDCISLKIGYINWSIDKLLININDIIDYLINKEYFSTIGGGEGIIKDLNNLGNIHVKTNQSISLPIIDNNGMPKGNNDGEEEEDSDFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIL8</accession>
    <name>C4YIL8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Pyruvate kinase</fullName>
            <ecNumber evidence="6 16">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAWG_04294</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="6 16"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIL8"/>
    <dbReference type="PaxDb" id="5476-C4YIL8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04294"/>
    <dbReference type="HOGENOM" id="CLU_015439_0_1_1"/>
    <dbReference type="OMA" id="RVHHIGE"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 16" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 16 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 19" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="17">
        <location>
            <begin position="23"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="18">
        <location>
            <begin position="384"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEQ45953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="504" mass="55503" checksum="FBACBC3AE831E3B0" modified="2009-07-28" version="1">MSHSSLSWLSNFNVETVPSKYLRRSSIIGTIGPKTNNVDVLVKLRKAGLNVVRMNFSHGSYEYHQSVIDNARKSEEVYKGRPLAIALDTKGPEIRTGTTIDDKDYPIPPNHEMIFTTDDAYKTKCDDKVMYIDYKNITKVIAPGKIIYVDDGVLSFEVISVDDEQTLKVRSLNAGKISSHKGVNLPGTDVDLPALSEKDIADIKFGVKNKVHMIFASFIRTANDVLEIRKVLGEEGKDIQIISKIENQQGVNNFDEILEVTDGVMVARGDLGIEIPAPQVFVVQKQLIAKCNLAAKPVICATQMLESMTYNPRPTRAEVSDVGNAILDGADCVMLSGETAKGNYPVEAVSMMHNTCLTAEKAIAYPQLFNELRSLAKKPTATTETCAVAAVSAAYEQDAKAIVVLSTSGLSARLVSKYKPDVPILMVTRNERAAKFSHLYRGVYPFIYDKPSIENWQEDVENRLRWAVSEAVELGIISKGDSIVTVQGWTRGSGHSNTVRIVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIQ9</accession>
    <name>C4YIQ9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Cytochrome c oxidase subunit 8, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide VIII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_04336</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome c oxidase VIIc family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIQ9"/>
    <dbReference type="SMR" id="C4YIQ9"/>
    <dbReference type="PaxDb" id="5476-C4YIQ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04336"/>
    <dbReference type="HOGENOM" id="CLU_169812_0_1_1"/>
    <dbReference type="OMA" id="IHNRKIP"/>
    <dbReference type="OrthoDB" id="9974841at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.49.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.49.10">
        <property type="entry name" value="Cytochrome c oxidase subunit VIIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004202">
        <property type="entry name" value="COX7C/Cox8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036636">
        <property type="entry name" value="COX7C/Cox8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13313:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13313">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT VIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02935">
        <property type="entry name" value="COX7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81427">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ45994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="93" mass="10945" checksum="8976E9744086C728" modified="2009-07-28" version="1">MFAQSALRPARTLPSRILTRRNFQVSARKFDINTIVYGTAKEGPYENLPFKIKNRKFVPFAVWYWGVLGFFFAFPFLTSWWQLKKSGAFNKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIR1</accession>
    <name>C4YIR1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIR1"/>
    <dbReference type="PaxDb" id="5476-C4YIR1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04338"/>
    <dbReference type="HOGENOM" id="CLU_344541_0_0_1"/>
    <dbReference type="OMA" id="EFHIFFV"/>
    <dbReference type="OrthoDB" id="10262287at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="698" mass="80070" checksum="60B35996B7F789AD" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIR2</accession>
    <name>C4YIR2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_04339</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIR2"/>
    <dbReference type="SMR" id="C4YIR2"/>
    <dbReference type="PaxDb" id="5476-C4YIR2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04339"/>
    <dbReference type="HOGENOM" id="CLU_032690_2_1_1"/>
    <dbReference type="OMA" id="WGIDNEQ"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.210:FF:000004">
        <property type="entry name" value="Acyl-CoA thioesterase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="4">
        <location>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ45997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="353" mass="40030" checksum="323ABBE25A0426C0" modified="2010-10-05" version="1">MFEYNYKFGETVDVQKEFGVTKISDNKYVGVKPLIKPSPQSRGAFGGNLVGQALLVAIRSCPEGFSPHSLHSYFIRAANVETPVEWEVEIISNGKSFSNRAVKGIQEGVVVYMANISLTKKNSYKEALQKHEEHYAKIQQRGKDGDVEEDVDEDDEDEPGPPKPFSFQTPPSSSLKKYDIDKLPVSAMESTLLLYYKFPPEFVKLSKSLEENSLPPAERRLTALAKWGIENEQGYDQPLTNLTKDFQFVGLANVTDGLYLGTLLRLLRVKDIDTKIHSTDYVGISLDHVIYFHDDDFDVTKWMEFSYKCTRYAQDRVDFEGEIYNDKGVQVASFFQQGLVRFENGALLEKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIS2</accession>
    <name>C4YIS2_CANAW</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
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                <person name="Staggs R."/>
                <person name="Stansfield I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
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    <dbReference type="HOGENOM" id="CLU_173452_0_0_1"/>
    <dbReference type="OMA" id="IELNGYF"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="84" mass="10035" checksum="049EAE81A1509E0E" modified="2009-07-28" version="1">MEYTRSVRISIIFRKNDMLSWYTNLQNACLDSPTSFSTIQFGCSNYILYSIELNGYFIFDCQCYISTTVSYNKRYYVMNFKVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJF0</accession>
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        <recommendedName>
            <fullName evidence="4">Antagonist of mitotic exit network protein 1</fullName>
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        <lineage>
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            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
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                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
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                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
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                <person name="Lorenz M.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
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    <dbReference type="EMBL" id="CH672350">
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    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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            <dbReference type="EMBL" id="EEQ45634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="64123" checksum="7370F373252D5132" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJG8</accession>
    <name>C4YJG8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal domain-containing protein</fullName>
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            <taxon>Debaryomycetaceae</taxon>
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            <taxon>Candida</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
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                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
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                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
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                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
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                <person name="Stansfield I."/>
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                <person name="Srikantha T."/>
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            <dbReference type="PubMed" id="19465905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
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    </comment>
    <dbReference type="EMBL" id="CH672350">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="HOGENOM" id="CLU_078884_0_0_1"/>
    <dbReference type="OMA" id="PMWYNTP"/>
    <dbReference type="OrthoDB" id="5835136at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal" evidence="7">
        <location>
            <begin position="20"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ45652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="356" mass="41637" checksum="1FC3255AACAF3C6D" modified="2009-07-28" version="1">MLQLHVWGKDNEISIISPSCIASAYLLNQVLTPQNIEFEIIPSNNTNLSDINQLPVLIDNETKEKYNGYNEIIRFIESKYLSTSTKLSLVSYLPSDSLKTTKEKLINKGLINLLINKFEYINQYNLYLNNKNYENYTRKLFSSYLPFPMMYNQPSKYYAQAQEQVKILGLSKQKVSFFDFTTGNNEQGSIDVAPTELINDEDDEEGDEDEDGANVAISSLHERQLLKKSKSKQVLKESRNSMKCLILITQYIERFKTIFQHQQRDSDEEFGYIFNNQNPSSSEILFYAYIFCLTYEKLPDRFIFNYLKLKQDYTLKFITEIMNKNQISKNKFRNPIGNEIPSLTNEVKYWIGSIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJU0</accession>
    <name>C4YJU0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAWG_04110</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="17">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJU0"/>
    <dbReference type="PaxDb" id="5476-C4YJU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04110"/>
    <dbReference type="HOGENOM" id="CLU_031900_2_0_1"/>
    <dbReference type="OMA" id="PIYITPQ"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16858">
        <property type="entry name" value="ING_ING3_Yng2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000436">
        <property type="entry name" value="Chromatin modification-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF100">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN YNG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 17" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15 17" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 16 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="19">
        <location>
            <begin position="237"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="138"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="14">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="14">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="14">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="14">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00063794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEQ45774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="298" mass="33745" checksum="532B383DB512F944" modified="2009-07-28" version="1">MDTSTVLEKYTQDLSNLPLEVRHLLEEIKSKDVQVSEARKRYQTRDHQLHKFIRTNGTLTKHPKEDQLYSKIEEDMKLVQKLQKEKILLANTALFLISKHLYHFETDIAKLERDELLPPLEHPIELTEVPKDEYAKSLNGFSDSASATPTPRNGSSATPVAETVKKIQKKKLSVKGASSSSAQSSSASRQVKRLRSEEIEDPQPYEGGSLAFNGNVAMSINSAADANGPNGEDADNNLYCFCQRVSFGEMIGCDNEDCKYEWFHWSCVGITSPPKDDEIWYCPDCASKMEKRKKKRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJW6</accession>
    <name>C4YJW6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_04137</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJW6"/>
    <dbReference type="PaxDb" id="5476-C4YJW6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04137"/>
    <dbReference type="HOGENOM" id="CLU_010370_1_0_1"/>
    <dbReference type="OMA" id="YAMYCLT"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016241">
        <property type="entry name" value="Nnk1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000610">
        <property type="entry name" value="Ser/Thr_PK_YKL171w_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="456"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="291"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ45800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="965" mass="108963" checksum="72861C92C465AEF9" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK67</accession>
    <name>C4YK67_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">mRNA export factor GLE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Nuclear pore protein GLE1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Nucleoporin GLE1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">RNA export factor GLE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_05863</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GLE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK67"/>
    <dbReference type="PaxDb" id="5476-C4YK67"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05863"/>
    <dbReference type="HOGENOM" id="CLU_029651_0_0_1"/>
    <dbReference type="OMA" id="VPANIHS"/>
    <dbReference type="OrthoDB" id="420884at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.510:FF:000003">
        <property type="entry name" value="Nucleoporin GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.510">
        <property type="entry name" value="GLE1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012476">
        <property type="entry name" value="GLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038506">
        <property type="entry name" value="GLE1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960">
        <property type="entry name" value="GLE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960:SF0">
        <property type="entry name" value="MRNA EXPORT FACTOR GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07817">
        <property type="entry name" value="GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="127"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00075092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00075681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ47296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="500" mass="59246" checksum="DE87E81760F62940" modified="2009-07-28" version="1">MKFGLPDNFEVVVDVSSKPANQITLSLIKPSRPKNTFNDVFKKTCNDIDENTLDFIKSKQNEINERVDTLQSKMKSREAQADANITHLIQDFNSQLRIQNEQVEELIRKEKERIRLELERKRREEEERRRREEEERRRQEEEERRRKEEEERKRKEEAKRLEEEERKRKEEEEARKKREAELKRQQELKIQREKELLEQKKKERESRFTTDYNQIEKTLYKYKQDIQDIKNNVKLKLNEDPDLKKQVNQYKRKINPKFGQLSNSLSQFNKISTEVIGMIKAVETNALVFKWVLNFTAKAIIDQAETEVIVRPNSAVPLAKLAYAILQAIPDFEYYLNARFIKKCPYIIGYNCSIDSEEGRERMGWKRPDGSKWEEETKYDERMGGIVSVWAAMTTITNHGSQKSLYSFEASWQFLARTANLQTSMLVNTHFTILGNWWEAAGASFLGVYGNQSQKLMYIVVVQLTDVVASKKFPSAARLRIMGEEWVTRRQIQSLKAMEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKA9</accession>
    <name>C4YKA9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_05906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKA9"/>
    <dbReference type="PaxDb" id="5476-C4YKA9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05906"/>
    <dbReference type="HOGENOM" id="CLU_1133456_0_0_1"/>
    <dbReference type="OMA" id="LAVEYNM"/>
    <dbReference type="OrthoDB" id="4014124at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ47338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="231" mass="26559" checksum="EA48B76C309F9DBA" modified="2009-07-28" version="1">MESTPIEGVSYQDDSTLLASQFFYFDNLQTLQPKLSQIFATSIPTPIIQLLDTTHYLIPDDNESSSENHFNNTIPLNWIEFYTENVSYEMNRQAEIIVMTHETVDNKYAHGDLAYTWSMLKKLAVEYNMALSLYAGFYYMVGLLTGARISPEFDITSSLSIMYACPVANGKTVQLKVYPTLAKLTPYYRKLKWNSKLQKFIVKNKFTKHKKIKLLALTGLEDVECAYVHNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKM4</accession>
    <name>C4YKM4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_06030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKM4"/>
    <dbReference type="PaxDb" id="5476-C4YKM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06030"/>
    <dbReference type="HOGENOM" id="CLU_102602_3_1_1"/>
    <dbReference type="OMA" id="TKDIHRT"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF95">
        <property type="entry name" value="CYTOCHROME B5 TYPE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="40"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ47453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="236" mass="26819" checksum="9A47860E3BA915C2" modified="2009-07-28" version="1">MPSIDQEIPPLPSSLSPSSPSIIDKISSVKNDDNNRTKLYSIYSLDQVKIHDKPNDLWMILYNKVYDITNFTSVHPGDVEVLLDCGGADATEAFEDVGHSDFAFQMLKPYLIGELQLSDKKKYESKLLSARKIEVTSDNNNTNGITSKKGNTDNNGILTNGKHIKTKKTNNNSNNNDNITTKDIHRTGITKSKKKRRNNNKPNKIREHFRMLSLGILALVSLILFLYIQRFRWLHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKP0</accession>
    <name>C4YKP0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_06046</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKP0"/>
    <dbReference type="SMR" id="C4YKP0"/>
    <dbReference type="PaxDb" id="5476-C4YKP0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06046"/>
    <dbReference type="HOGENOM" id="CLU_042569_3_0_1"/>
    <dbReference type="OMA" id="FRICGMK"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF103">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE MULTIKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ47469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="350" mass="39511" checksum="7340DB98D34D4D75" modified="2010-10-05" version="1">MIPTLNSLTPSKHQAAGHDGCLATDSLFIKLTVQQEIDFYTQVQSHDQSVQDAPLGSQLSHWMPTFMGTLTQGDVSKTQTAGSDQSSSAEGQTDKQYIVLSNSYHGFTHPSILDIKLGAKLTDDEVTAPEKIARLQKVSDSTTSGSLNFRICGMKVYNGKSDTKPANELYENMNDSSVSVNINDADDHKYLEFNKFYGRSLSKDNIKEGLELYFNNHLPKAIVKRLLVVFHKRLQLLYNCLLDYEVRIFSGSLLFIYESDLTKWENVTEDNYDTYDSLVREIVDDEDEDDEEFEEDSKKDKTQPLTPLSSLNFIDFAHAKFVEGQGHDENIVQGIENLIDIFNALIAKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKR1</accession>
    <name>C4YKR1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfurtransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_06068</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKR1"/>
    <dbReference type="PaxDb" id="5476-C4YKR1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06068"/>
    <dbReference type="HOGENOM" id="CLU_031618_3_1_1"/>
    <dbReference type="OMA" id="NNNWFAS"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01449">
        <property type="entry name" value="TST_Repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000069">
        <property type="entry name" value="Sulfurtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00683">
        <property type="entry name" value="RHODANESE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="42"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="196"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ47490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="335" mass="38234" checksum="BF2F6810195D5CB9" modified="2009-07-28" version="1">MSRSFLTTITPSAYRALLSTSNPSKRVIPIDATWYMPNNLKNAKQEFIKERIPNSKFFDLDKYIDPTSPYPHMLPSKISIMEQAYKDLQLNLNDSIVVYDKLGIFSSPRAAWTFSLFGHPKVYLLDNYLNYKQSEYPIDENPPPIEEEEQNKGEIENLVNPVKLDQDQFNENYKQQVIEYEELLDLVTKKKNNGYGLKDYLLLDARSLDRFTGKANEPRPGLSSGHIPGAINLPFNTLLTGNNNQFKNKQEILEIFHEKNILNGNGDGNGDDKIENLLTNYPKGIIVMCGTGVTAVILKFAIECILKLNVPVRVYDGSWTEWASRAPSEYIQKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL07</accession>
    <name>C4YL07_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL07"/>
    <dbReference type="PaxDb" id="5476-C4YL07"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01521"/>
    <dbReference type="HOGENOM" id="CLU_082196_1_0_1"/>
    <dbReference type="OMA" id="KTTHDHT"/>
    <dbReference type="OrthoDB" id="3366546at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF26">
        <property type="entry name" value="PROTEIN TMA23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27810" checksum="CD0175A20702914C" modified="2009-07-28" version="1">MNASIYLQSFGWKEGEALKKGGLKKPILVKHKKDTKGLGHDTNDSDMWWEKLFDGQLKNLEVNNNNKNGGVSFETNEEKVVDAFQKSISPLYKMFVKGEGLAGTVGKTDHTKESHREISSSKALEDMEKLTNKDTFMENIKDNASSSDEKDSKKKKKSDKKTKDRKESKKSKHGKSKVDSSSKIDKEKKKSKKKSKDGILSKEKKRSKSNKTKKDKDVTSSKDSKKKKRKSESNDETTKSKKRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLA9</accession>
    <name>C4YLA9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_01626</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLA9"/>
    <dbReference type="PaxDb" id="5476-C4YLA9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01626"/>
    <dbReference type="HOGENOM" id="CLU_1772465_0_0_1"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ43390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="147" mass="16694" checksum="2C568A4CCE5848DA" modified="2009-07-28" version="1" fragment="single">IDFFALGTDVVFLIPLITTIYARTGFTLFEELIVGYIIRENGLALAFIKALGYNIDEQAQNFLNDLKQGHYAKLPPRVVYRVQILSVFVALFIQLGILKFQINGIKDYYKPGNTQKFTCLGGRTFFLASVLWGVIGPRRFFNGVYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLX1</accession>
    <name>C4YLX1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein bir1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
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    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM93"/>
    <dbReference type="SMR" id="C4YM93"/>
    <dbReference type="PaxDb" id="5476-C4YM93"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01971"/>
    <dbReference type="HOGENOM" id="CLU_027444_2_0_1"/>
    <dbReference type="OMA" id="VILVRKH"/>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="9">
        <location>
            <begin position="23"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="11">
        <location>
            <begin position="255"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="10">
        <location>
            <begin position="319"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="470"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="486"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ43724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="520" mass="59208" checksum="06A7E0138A46B60B" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMC3</accession>
    <name>C4YMC3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Pyrimidine-specific carbamoyl phosphate synthase-aspartate carbamoyl transferase</fullName>
            <ecNumber evidence="6">2.1.3.2</ecNumber>
            <ecNumber evidence="5">3.5.1.2</ecNumber>
            <ecNumber evidence="19">6.3.4.16</ecNumber>
            <ecNumber evidence="4">6.3.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">CAWG_02002</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30 31">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="24">Multifunctional protein that encodes the first 2 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5) and aspartate transcarbamylase (ATCase; EC 2.1.3.2). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">In the 2nd section; belongs to the CarB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">In the N-terminal section; belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="6"/>
    <dbReference type="EC" id="3.5.1.2" evidence="5"/>
    <dbReference type="EC" id="6.3.4.16" evidence="19"/>
    <dbReference type="EC" id="6.3.5.5" evidence="4"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="C26.956"/>
    <dbReference type="PaxDb" id="5476-C4YMC3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02002"/>
    <dbReference type="HOGENOM" id="CLU_000513_2_1_1"/>
    <dbReference type="OMA" id="WSPFNGK"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01423">
        <property type="entry name" value="MGS_CPS_I_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000002">
        <property type="entry name" value="Aspartate carbamoyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000036">
        <property type="entry name" value="Aspartate carbamoyltransferase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000025">
        <property type="entry name" value="Bifunctional pyrimidine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000005">
        <property type="entry name" value="CAD protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000036">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000009">
        <property type="entry name" value="Carbamoyl-phosphate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002032">
        <property type="entry name" value="PRK00856.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF5">
        <property type="entry name" value="CAD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00101">
        <property type="entry name" value="ATCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 26" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 26" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="28">
        <location>
            <begin position="566"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="28">
        <location>
            <begin position="1104"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="29">
        <location>
            <begin position="1361"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1843"/>
            <end position="1873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00043979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00043984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00058513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00081752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="EEQ43754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="2216" mass="244675" checksum="2F06ADB5199DC415" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMF2</accession>
    <name>C4YMF2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMF2"/>
    <dbReference type="PaxDb" id="5476-C4YMF2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02032"/>
    <dbReference type="HOGENOM" id="CLU_778447_0_0_1"/>
    <dbReference type="OMA" id="PDDNETK"/>
    <dbReference type="OrthoDB" id="4091843at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="98"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ43783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="357" mass="40905" checksum="4B71C06D6BBFF214" modified="2009-07-28" version="1">MSSNPAKHIGIKQQKLIEESIKNYVVYYDKTFSSYLKLRSDILELHNTVRLLSTHKEKRNNSNPDDNETKEEVSTAEENSISKDEIEPDNIKIDEADAESFKNKLAEAAVRLEQLKFEADKVQITYESYLDELRNILAIESRKHAEGYQPEVLTDAKNKLSSLVNQETELNAKIDDIKTVQKPLLDKVTNLVSNFNSNVTSSTARVIHPSLLRNIDDEGTENSVQVNYNHLVFAKSDISRFFAERTAVSELNDVLLSQVQDILESNSRVFDKVETQSSSEDSQKLLYKLARSSLHDINQNTDLDEYDDLIDKAIKDISISYQENQVIKAQWSKHARKVEKIKHILEEQDEDGDIEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMF8</accession>
    <name>C4YMF8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="11">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_02038</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="11"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMF8"/>
    <dbReference type="SMR" id="C4YMF8"/>
    <dbReference type="PaxDb" id="5476-C4YMF8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02038"/>
    <dbReference type="HOGENOM" id="CLU_016755_0_1_1"/>
    <dbReference type="OMA" id="CAQLGMK"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="2 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="13">
        <location>
            <begin position="26"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="12">
        <location>
            <begin position="372"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="168"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="205"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="344"/>
            <end position="347"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="64"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ43789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="491" mass="52857" checksum="80C935977DE0E0A9" modified="2010-10-05" version="1">MLRSFKSIPANGKLAQFVRYASTKKYDVVVIGGGPGGYVAAIKAAQLGLNTACIEKRGALGGTCLNVGCIPSKSLLNNSHLLHQIQHEAKERGISIQGEVGVDFPKLMAAKEKAVKQLTGGIEMLFKKNKVDYLKGAGSFVNEKTVKVTPIDGSEAQEVEADHIIVATGSEPTPFPGIEIDEERIVTSTGILSLKEVPERLAIIGGGIIGLEMASVYARLGSKVTVIEFQNAIGAGMDAEVAKQSQKLLAKQGLDFKLGTKVVKGERDGEVVKIEVEDVKSGKKSDLEADVLLVAIGRRPFTEGLNFEAIGLEKDNKGRLIIDDQFKTKHDHIRVIGDVTFGPMLAHKAEEEGIAAAEYIKKGHGHVNYANIPSVMYTHPEVAWVGLNEEQLKEQGIKYKVGKFPFIANSRAKTNMDTDGFVKFIADAETQRVLGVHIIGPNAGEMIAEAGLALEYGASTEDISRTCHAHPTLSEAFKEAALATFDKPINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMM0</accession>
    <name>C4YMM0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMM0"/>
    <dbReference type="PaxDb" id="5476-C4YMM0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02103"/>
    <dbReference type="HOGENOM" id="CLU_050407_0_0_1"/>
    <dbReference type="OMA" id="ACIETDI"/>
    <dbReference type="OrthoDB" id="4078956at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="424" mass="48835" checksum="34963FFB25184A5E" modified="2009-07-28" version="1">MSFVRNRNNKRQRTGRGPRKPKSNRDKEERQLSIRNEEGYFSKATKLGSSNEFVDFETSIQPYLWTTVTPVIESATRTHASARMPTLKRLCAEQLARNVEYIGWHLIASAPWSIWKLVWTIIVKTGQDSPETYAKFAKFFHSFQDFRAHRYLLEQGIRGQAIGKYLIPGCRLHRVETVFRNIDLHDTIKFLDIWQPITILDLSLIKLSRDEYFALFNIPNLVCLSLCNHDIDDTFIASLCSTIKNGKLWKLSVLKIENTKVTKTGIMSLFALGKESCDLACIETDIPIVDNYACSTNWSKLDNESASIYRLPLALKLNALMKKNILQTSIINDNIMDLMVVDKTWHSSNASQENINSAWEARKDATIKRYRGKTYIRKHELQKVDGPNGIDAVSSTENTLLPTEQRRKKHKNRIQLNAKNFFCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMM1</accession>
    <name>C4YMM1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_02104</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMM1"/>
    <dbReference type="PaxDb" id="5476-C4YMM1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02104"/>
    <dbReference type="HOGENOM" id="CLU_014214_0_0_1"/>
    <dbReference type="OMA" id="PLIWKWG"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="NUDIX_Dcp2p_Nudt20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1050:FF:000003">
        <property type="entry name" value="Decapping enzyme Dcp2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000045">
        <property type="entry name" value="mRNA-decapping enzyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007722">
        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044099">
        <property type="entry name" value="Dcp2_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01125">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="Dcp2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="12">
        <location>
            <begin position="99"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="351"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="446"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="546"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="601"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="679"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="847"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="285"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="632"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="656"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="847"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="894"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ43852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="907" mass="102140" checksum="B2AAB2F0841577A6" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMR0</accession>
    <name>C4YMR0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein AFG2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_02144</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="C4YMR0"/>
    <dbReference type="PaxDb" id="5476-C4YMR0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02144"/>
    <dbReference type="HOGENOM" id="CLU_000688_12_3_1"/>
    <dbReference type="OMA" id="DRHIYVA"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19503">
        <property type="entry name" value="RecA-like_CDC48_NLV2_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19511">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000132">
        <property type="entry name" value="AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000157">
        <property type="entry name" value="AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001721">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="5">
        <location>
            <begin position="36"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="262"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="532"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ43891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="766" mass="83120" checksum="BC030321A9A55130" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMT6</accession>
    <name>C4YMT6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Actin-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_02173</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMT6"/>
    <dbReference type="PaxDb" id="5476-C4YMT6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02173"/>
    <dbReference type="HOGENOM" id="CLU_027965_0_2_1"/>
    <dbReference type="OMA" id="WEDMQHL"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000005">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="41162" checksum="D1CF8CD82892F8CB" modified="2009-07-28" version="1">MVGRPILRAEERNILVPSDVEIKDIMCGSEASQVRSLLQINYPMENGIIKNWEDMEHLWDYAFYERMKINPQGQKILLTEPPMNPLKNREMMCQVMFEKYGFDGVYVAIQAVLALYAQGLSSGVVVDSGDGVTHIVPVYESVVLNHLTKRLDVAGRDVTRHLINLLFRRGYAFNRTADFETVRQIKEKLCYVSYDLGFDAKLARETTTLVESYELPDGRVIKVGSERFEAPECLFQPHLVDVEQPGVGEILFNTIQSADVDIRSSLYKAIVLSGGSSMYPGLPSRLEKELKQLWLTRVLQGDASRLDKFKVRIEDPPRRKHMVFIGGAVLANIMADKDHMWISKQEWEEQGPRVLEKLGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN13</accession>
    <name>C4YN13_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_02251</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN13"/>
    <dbReference type="SMR" id="C4YN13"/>
    <dbReference type="PaxDb" id="5476-C4YN13"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02251"/>
    <dbReference type="HOGENOM" id="CLU_000688_15_0_1"/>
    <dbReference type="OMA" id="YNKPKPM"/>
    <dbReference type="OrthoDB" id="10251136at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000022">
        <property type="entry name" value="Fidgetin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000093">
        <property type="entry name" value="Fidgetin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF17">
        <property type="entry name" value="FIDGETIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="570"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="104"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="223"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="288"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="120"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="368"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="424"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ43994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="820" mass="90116" checksum="1B25EFBD02F20E3B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN27</accession>
    <name>C4YN27_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN27"/>
    <dbReference type="PaxDb" id="5476-C4YN27"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02267"/>
    <dbReference type="HOGENOM" id="CLU_037643_0_0_1"/>
    <dbReference type="OMA" id="WDHEIIV"/>
    <dbReference type="OrthoDB" id="4018787at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="521" mass="58335" checksum="940382B44C6280B4" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNB0</accession>
    <name>C4YNB0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNB0"/>
    <dbReference type="PaxDb" id="5476-C4YNB0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01366"/>
    <dbReference type="HOGENOM" id="CLU_049337_0_0_1"/>
    <dbReference type="OMA" id="QFAYERA"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="379" mass="43589" checksum="BF22DB36FFF1BDD1" modified="2009-07-28" version="1">MSSTVTQTMNNNPTEKVTFTASNSQADFDLLDIFSNDMDFEQAYDMYNNLQEKNAMGSFEQLQKVQALNQQYVSNLQPPSSAQFPDQFAYERAQILNGEYNKQPGLMNDATNKNYSFNDDTFDQFFTNTESNALEKFLDNLANPVASVNPLQFYNNTRTSVPDEDVDLSFELHTMKVPQQFKPRSQSLEHNPPLQQKVRFTEEEHAALKQELTEAFAHPCTQLPSPSTTEYKPKPTTPKVVKQFVTPPNSGDKSRKRNSDIESDESEEETTPTTKKRKRTSSKPLLSVEQKRLNHSHSEQKRRQLCKFAYQRCLELIIDLDAFNKLPELNESERKSKRARVNKDGLPNLSKHNALIRISNEMILIKSMNDSLKKLIENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNI8</accession>
    <name>C4YNI8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_01450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNI8"/>
    <dbReference type="PaxDb" id="5476-C4YNI8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01450"/>
    <dbReference type="HOGENOM" id="CLU_1839848_0_0_1"/>
    <dbReference type="OMA" id="NPAPLAM"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ43221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="140" mass="15582" checksum="F2AA9B9E261C867F" modified="2009-07-28" version="1" fragment="single">NTFATTTMISYGTFFLSYGALYIPSFGIMKAYATVDPTLKELQNAIGFFLIAWAIFSFFMLLCTMKSVISLFVLFVFIFFTFFLQGIGFLLEHHGLIKAGNVFGILVTAAGLFNAWAGVATSTNSYFVIPITWLSRHHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNL6</accession>
    <name>C4YNL6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_01479</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNL6"/>
    <dbReference type="PaxDb" id="5476-C4YNL6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01479"/>
    <dbReference type="HOGENOM" id="CLU_010714_4_0_1"/>
    <dbReference type="OMA" id="VVGFEVY"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF55">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="516"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="555"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="589"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ43249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="628" mass="71332" checksum="19A62C778E656EDC" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNN9</accession>
    <name>C4YNN9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNN9"/>
    <dbReference type="PaxDb" id="5476-C4YNN9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02820"/>
    <dbReference type="HOGENOM" id="CLU_026673_16_5_1"/>
    <dbReference type="OMA" id="FQEYAIV"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="57"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="404" mass="45442" checksum="DF43839ACCD6FF68" modified="2009-07-28" version="1">MTTTVIKTQERTRKRLRTNTSEIVFKESYQEKTTNDEQEDVAIVPPTEISFDKKHQSILSITHFKDPLKVQSRYPIPELQPYEILVNNKAIGLNPIDWKGKKYGFGIYHFPWINGRESSGDVVKLGDQVDKFSIGDKVIVSSTSYRDNRTSTFQQYTAIDSRLVWKLPESFSYEDGATIGVGLVTAGIILYNSFEFELSATPTKQTTTASNNNTILIWGGATVVGLYVAQLAKIYGLNVIAVASTKHETYLKQLGVDHLIDRHLSEDEIINEINSIDGIESIEYGVDCVGKETSKTVLKILDLKSQPQQKSKDEQIVKPKFSGIVGVPKEYPESVDVRNVVIKRFHEDVSFGEKFIDVTSELLNKKVIEPVRFKQYKGGLHIIDNALKDLEKIGANGEKYVVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNP3</accession>
    <name>C4YNP3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_02824</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNP3"/>
    <dbReference type="SMR" id="C4YNP3"/>
    <dbReference type="PaxDb" id="5476-C4YNP3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02824"/>
    <dbReference type="HOGENOM" id="CLU_083737_0_0_1"/>
    <dbReference type="OMA" id="YNWDVAQ"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000001">
        <property type="entry name" value="Prefoldin subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016396">
        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="133"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ44552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="185" mass="21807" checksum="9CD90701695FB05F" modified="2009-07-28" version="1">MADFLAPKKTNPRGIPEAPFIEKVETVIKNPETEFDNTMSMFQQRLQQYKYMEASKKQQLADLQTKIPDIEKNLDVIKHIKQRKEEGDDKMVTNYELNDTLYSKATVDVQNLNSVYLWLGAEVMLEYNLEDATELLNERLKKNQEQLQIVKEDLEFLKENITTMEVNTARLYNWDVERRKKAKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNR4</accession>
    <name>C4YNR4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.256</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_02847</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = a alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29543"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19512"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="ChEBI" id="CHEBI:132523"/>
            <dbReference type="EC" id="2.4.1.256"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:29544"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the ALG10 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.256" evidence="4 14"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNR4"/>
    <dbReference type="PaxDb" id="5476-C4YNR4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02847"/>
    <dbReference type="HOGENOM" id="CLU_017053_1_0_1"/>
    <dbReference type="OMA" id="VWDSKIT"/>
    <dbReference type="OrthoDB" id="4769at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106073">
        <property type="term" value="F:dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016900">
        <property type="entry name" value="Alg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989">
        <property type="entry name" value="ALPHA-1,2-GLUCOSYLTRANSFERASE ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989:SF10">
        <property type="entry name" value="DOL-P-GLC:GLC(2)MAN(9)GLCNAC(2)-PP-DOL ALPHA-1,2-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04922">
        <property type="entry name" value="DIE2_ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028810">
        <property type="entry name" value="Alpha1_2_glucosyltferase_Alg10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR028810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ44573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="418" mass="49125" checksum="B61FEA8FC11DA24D" modified="2009-07-28" version="1">MFNNITHHLTQPYIDEIFHLRQCQTYCQYNFHHWDNKITTPPGLYILGFIYSEGIKILTRSSSTGGGGGHLTCFNDNVLRSINLIGGVVILPRILQQFHNGWSKNSKNQFFWSINIISQPLLFTYYFLFYTDVWSTILIMLSLGLINYKLLQYPMLSALVGFISLWFRQTNIIWIAFIASIFIDRQIKIKTGVIDRIRQFIMKSLTNWNKLLGYIVNIILFVIFLKLNGGITLGDNDNHQIELHIVQVFYCFTFITFFTIPNWLNKSTIKKYYNFIINHIILNLIIGLIIWYIMENFTIVHPFLLADNRHYAFYIYKRLLSQSYLKPLILMAYHFSSFQIISSLIKGGQLSFIGIFSYLIAVGLTLIPSPLFEPRYYITPLIIFNLYINHPHNLLEFIWLNSINLITSYIFLHKGIIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNR5</accession>
    <name>C4YNR5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Knr4/Smi1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_02848</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KNR4/SMI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNR5"/>
    <dbReference type="PaxDb" id="5476-C4YNR5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02848"/>
    <dbReference type="HOGENOM" id="CLU_027501_0_0_1"/>
    <dbReference type="OMA" id="TQNDITH"/>
    <dbReference type="OrthoDB" id="2305498at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070880">
        <property type="term" value="P:fungal-type cell wall beta-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Knr4/Smi1"/>
    </dbReference>
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        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051873">
        <property type="entry name" value="KNR4/SMI1_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432:SF1">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017023">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
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        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Knr4/Smi1-like" evidence="3">
        <location>
            <begin position="104"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="474"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ44574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="550" mass="61867" checksum="0B77BE0AC705C848" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNX6</accession>
    <name>C4YNX6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_02909</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000001429">
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0044403">
        <property type="term" value="P:biological process involved in symbiotic interaction"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070783">
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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        <property type="term" value="P:regulation of filamentous growth of a population of unicellular organisms"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900239">
        <property type="term" value="P:regulation of phenotypic switching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000075">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
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        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ44635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="624" mass="72335" checksum="46FD8ED01AA63099" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP68</accession>
    <name>C4YP68_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_03011</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YP68"/>
    <dbReference type="PaxDb" id="5476-C4YP68"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03011"/>
    <dbReference type="HOGENOM" id="CLU_016808_0_0_1"/>
    <dbReference type="OMA" id="ILAPCPQ"/>
    <dbReference type="OrthoDB" id="5817083at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14596">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14596:SF72">
        <property type="entry name" value="ZINC FINGER PROTEIN MSN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="708"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="515"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ44727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="837" mass="93695" checksum="06E61E60BB49658D" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP93</accession>
    <name>C4YP93_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_03042</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YP93"/>
    <dbReference type="PaxDb" id="5476-C4YP93"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03042"/>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="OMA" id="METWRGM"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004032">
        <property type="term" value="F:aldose reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019568">
        <property type="term" value="P:arabinose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042843">
        <property type="term" value="P:D-xylose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042180">
        <property type="term" value="P:ketone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000018">
        <property type="entry name" value="Glycerol dehydrogenase Gcy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="8">
        <location>
            <begin position="27"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="7">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ44752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="289" mass="32607" checksum="53200C19A80404D7" modified="2009-07-28" version="1">MSAQLKTNNDRIALNNGNKIPVIGLGTWESNKDAFLTALKLGYRHIDTATIYKNEEQVGQSIKESGIPREELFITTKVWNNDHKNVEQALETSLKKLGLDYVDLYLVHWPVSIDKTTKEPYPDYDYVDTYKELQKIYKTTTKIKSIGVSNFTKSQLERLLSADGVDVVPAVNQVEAHPLLPQPELYEYLKEKGITLEAYSPLGTSSSPLIKNKTIVEIADKNGVDPAQVLISWAVQRKTVVLSKSVTESRLVSNLKTFELSAEDFDTLNKLSEKEGITRIINPFKNFQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPA4</accession>
    <name>C4YPA4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPA4"/>
    <dbReference type="PaxDb" id="5476-C4YPA4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03054"/>
    <dbReference type="HOGENOM" id="CLU_031506_3_1_1"/>
    <dbReference type="OMA" id="VPCFGWH"/>
    <dbReference type="OrthoDB" id="413993at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053044">
        <property type="entry name" value="Metallo-hydrolase/TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345:SF1">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="323" mass="37534" checksum="32CE710339BA9AC5" modified="2009-07-28" version="1">MNDTFLNLSDSHCHFNPECTASDTEKFAERLNEQSKQIPDNYFHLMTTQHLDLKFMDTLLTRLENPRVLVPYFGVHPWFSHLFYIEGTPTKEEHYKKVLKPEPSNELLATLPDPISLHKHKDRFLEIINKHNLEIYGIGEIGLDKLFRVPNNGYCGNLNFPSSTENKLSACRVDINHQLDVFKFQLTLAEQLKKQVSLHCVKAHGLLFDQVKKFSNITVILHSYTGSIEQAQVWIKSLPQNRLYFSFSNWINGEKIEALKALVTALRPTQILIESDIDVDRSFIEQRQTKHFDHLDGIYKKIHEHIFIDSLQIHNNMLNSIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPJ7</accession>
    <name>C4YPJ7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein PET191, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_02398</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PET191 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPJ7"/>
    <dbReference type="SMR" id="C4YPJ7"/>
    <dbReference type="PaxDb" id="5476-C4YPJ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02398"/>
    <dbReference type="HOGENOM" id="CLU_138069_1_0_1"/>
    <dbReference type="OMA" id="FLECKRG"/>
    <dbReference type="OrthoDB" id="282149at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018793">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_Pet191"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10203">
        <property type="entry name" value="Pet191_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ44136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="117" mass="13543" checksum="3A2743F32A3A8E70" modified="2009-07-28" version="1">MGASCKDQRKALAICLQRSPCVLLDRHTPKECLSDPDLKKDLPELCKAQFRAFMECKNGMFDMRKRMRGNAPLSTGKYDETFDNLSTGNFDPREEMRKLDVLNRNLSRQQQAQEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPL1</accession>
    <name>C4YPL1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 18">Delta(24(24(1)))-sterol reductase</fullName>
            <ecNumber evidence="15 18">1.3.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">C-24(28) sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Sterol Delta(24(28))-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAWG_02412</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:18249"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.71"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:18503"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="17">Steroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.71" evidence="15 18"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPL1"/>
    <dbReference type="PaxDb" id="5476-C4YPL1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02412"/>
    <dbReference type="HOGENOM" id="CLU_015631_3_1_1"/>
    <dbReference type="OMA" id="QLPYFCN"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000003">
        <property type="entry name" value="C-24(28) sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF31">
        <property type="entry name" value="DELTA(24(24(1)))-STEROL REDUCTASE ERG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10 18" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13 18" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEQ44150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="469" mass="54936" checksum="CCFED9F96596A9D9" modified="2010-10-05" version="1">MAASDTQSTSDETTPLVRSDESRYIPKDQIEYEFGGPIGALGMMIGFPLLMWYMWISAQFYNGQFALPSEGQSWKDFIIDDLFSKWVEYGIPSFGNWAFFTGFILIQALFYVTLPGVWTKGQPLTHLNNKQLPYFCNAIWSFYTSIVLSLVLHFTGVLPVYYMLDNVGGIMTTAIFYGISLSIILYLICIFVTGDYHRMTGNHIYDMFMGAPLNPRIGKYLDLKMFFEVRIPWFILFFLSFGLCFKQYETYGYVTPQACFMLYAHWLYANACAKGEELIVPTWDMAYEKFGFMLLFWNIAGVPFSYCQCILYIAYQEPEVYQWSIGYNVFLFVLITIAYYFFDTGNRQKNSFRRSVAGNSQLRKTFPYLPYSDLVNPKYIKCANGSLLLTDGWYVYARKMHYTADYIQTLTWALMCGFGSPFPWFFPIFFFIVLVHRGYRDQRKCAKKYGKDWDRYLEACPYMFIPYVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPT6</accession>
    <name>C4YPT6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_02488</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPT6"/>
    <dbReference type="SMR" id="C4YPT6"/>
    <dbReference type="PaxDb" id="5476-C4YPT6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02488"/>
    <dbReference type="HOGENOM" id="CLU_001832_5_11_1"/>
    <dbReference type="OMA" id="MKVYPLY"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022613">
        <property type="term" value="P:ribonucleoprotein complex biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17973">
        <property type="entry name" value="DEXHc_DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000324">
        <property type="entry name" value="pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000003">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044756">
        <property type="entry name" value="DHX15_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF109">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="104"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="294"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ44225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="767" mass="87156" checksum="0590F87DFF3777B7" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPX7</accession>
    <name>C4YPX7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_02531</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPX7"/>
    <dbReference type="PaxDb" id="5476-C4YPX7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02531"/>
    <dbReference type="HOGENOM" id="CLU_034022_2_1_1"/>
    <dbReference type="OMA" id="LWYPRIA"/>
    <dbReference type="OrthoDB" id="10260614at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000012">
        <property type="entry name" value="Rhomboid family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="8">
        <location>
            <begin position="166"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ44266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="327" mass="37359" checksum="B3D756F5844F4991" modified="2010-10-05" version="1">MFPFTKLTSNICLKNHFFSNGNLLSLSLKNMRQQKVLSFRSNIQLLQSNFIPIRGYIRETVYQQTRNSPLRRSSTWKQYNSFYNRSNWDKLKKPLLFTIAFCVGTTLVTPYLFTYTPLSYFKRNPQSLLWSLIGINGAVFLMWRIPRLQWFTMKYGILFKDNLQSPWTLLGSAFSHQSFAHFFINMLAFQSFGSTLVAFLGVSNFTIMYLNSAVISSFASLAIPMFLGSSLSVASLGASGAIFSVFGVFSFLFPASPVGLFFIPIPGGAWMLFLGTTLWNAAGTVLRWGTFDYAAHLGGSIVGIAYGYWYNRKRKQQIRRRRHTLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPZ4</accession>
    <name>C4YPZ4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_02548</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02548"/>
    <dbReference type="HOGENOM" id="CLU_032750_0_0_1"/>
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    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
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        <property type="entry name" value="TF_PAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023167">
        <property type="entry name" value="Yap1_redox_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111430">
        <property type="entry name" value="YAP1 redox domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="40"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="410"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
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            <begin position="419"/>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ41</accession>
    <name>C4YQ41_CANAW</name>
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        <recommendedName>
            <fullName evidence="4">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="DFFESYM"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="58245" checksum="A7B3329B1C31942A" modified="2009-07-28" version="1">MITTRIRPIMNNTSTHTNTKTSTTILTKRSATATTTTTSIPKQSSMSGQSKHAILIPSALNSLLHTDKQIKYHFYSLGGDFIRLASYRRFKQLFQVGGGSLVKQFVFDLSTFLKEELNDINSLRHHQLKNFLTCNKTILEKEKSMTLCDHHFGLKNWLYIIFGYMLQNYNEQEVNNCLDQLVSMYLEARSNRFSINDIRIIRDERDQFILSTFEQYLLDVPVRNDLLYNDNGNNEDVNYIILSNIKHHKRSNKNATIASNKDNNTTNRINLPKLPKIKDKSLLVKSLMHKEFYRVLLDPNHYFGKKMLDRNYSLDPQDYSLIRKELSILDGLGDLFLAQETSKLIYELICQKNHININSSTTYQLLKIMLATNTLMAKLTKAYNLYQGLDDSIINKRIAKEWLPFTILGETPPHSESSDWQSKDEIRIYEEEFLGDFFESYMAALLIEQPEVAKSFIREIYHRILMVMTETLPPDITYQTWTSNILGRNIYRKKSESIQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ55</accession>
    <name>C4YQ55_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02609</name>
        <name evidence="3" type="ORF">CAWG_02620</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
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        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ55"/>
    <dbReference type="PaxDb" id="5476-C4YQ55"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02609"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02620"/>
    <dbReference type="HOGENOM" id="CLU_1875168_0_0_1"/>
    <dbReference type="OMA" id="GRNIRND"/>
    <dbReference type="OrthoDB" id="4008099at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="136" mass="15384" checksum="EE3F32DB672D834D" modified="2010-10-05" version="1">MQRSWLQLISIVSRNIADDLKNNILNRPPILLILNPDSFEPPFTNGFDEYFNVTSTALLGQYSNSKAANYAIVALSIVLAGLDIIYSIIRLSISTMLMGAFLGSLLFFGLWFVVTASRRWKLVVLLFQNNDYNVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQU5</accession>
    <name>C4YQU5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SEC14 cytosolic factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQU5"/>
    <dbReference type="SMR" id="C4YQU5"/>
    <dbReference type="PaxDb" id="5476-C4YQU5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04442"/>
    <dbReference type="HOGENOM" id="CLU_014001_0_1_1"/>
    <dbReference type="OMA" id="WAFSTVW"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.20:FF:000005">
        <property type="entry name" value="SEC14 cytosolic factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000011">
        <property type="entry name" value="SEC14 cytosolic factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="99"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="301" mass="34709" checksum="1F194A8EA8B525BE" modified="2009-07-28" version="1">MTTMTTEEILASYPQITAPTDQTGYTSNLTPEQKTTLDIFRQQLTELGYKDRLDDASLLRFLRARKFDIQKAIDMFVACEKWREDFGVNTILKDFHYEEKPIVAKMYPTYYHKTDKDGRPVYFEELGKVDLVKMLKITTQERMLKNLVWEYEAMCQYRLPACSRKAGYLVETSCTVLDLSGISVTSAYNVIGYVREASKIGQDYYPERMGKFYLINAPFGFSTAFKLFKPFLDPVTVSKIHILGYSYKKELLKQIPPQNLPVKFGGMSDVSDDDLLLKDVGPWRDPEFIGPEGECPRAYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRJ2</accession>
    <name>C4YRJ2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_04692</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRJ2"/>
    <dbReference type="PaxDb" id="5476-C4YRJ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04692"/>
    <dbReference type="HOGENOM" id="CLU_076902_12_0_1"/>
    <dbReference type="OMA" id="DNYMNFQ"/>
    <dbReference type="OrthoDB" id="409625at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01722">
        <property type="entry name" value="Sm_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000070">
        <property type="entry name" value="Small nuclear ribonucleoprotein F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034100">
        <property type="entry name" value="Sm_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="7"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="86"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ46345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="126" mass="14721" checksum="1ED5BBB5B08B3AD8" modified="2009-07-28" version="1">MYFQPINPTPFLKSLIGKTIIVRLKWNKTQYKGTLVSIDNYMNLQLDQTYEIISESTDTDATKEELIGEIFIRCNNVLFIREYKEQQQPVDSKPIENGDKNGKIDKESVEEEEKVTNNEDIEIDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRP5</accession>
    <name>C4YRP5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRP5"/>
    <dbReference type="PaxDb" id="5476-C4YRP5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04748"/>
    <dbReference type="HOGENOM" id="CLU_005996_0_0_1"/>
    <dbReference type="OMA" id="LECITSW"/>
    <dbReference type="OrthoDB" id="435593at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000266">
        <property type="entry name" value="mRNA transport regulator MTR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057941">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
    </dbReference>
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        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058537">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF53">
        <property type="entry name" value="MRNA TRANSPORT REGULATOR MTR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="1">
        <location>
            <begin position="28"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="959" mass="110301" checksum="3E65028F2D965857" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS58</accession>
    <name>C4YS58_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS58"/>
    <dbReference type="PaxDb" id="5476-C4YS58"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04917"/>
    <dbReference type="HOGENOM" id="CLU_008694_1_0_1"/>
    <dbReference type="OMA" id="NPRDWAH"/>
    <dbReference type="OrthoDB" id="4097129at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="305"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="834" mass="96750" checksum="FBCD10949D20A61D" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS64</accession>
    <name>C4YS64_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_04923</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS64"/>
    <dbReference type="PaxDb" id="5476-C4YS64"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04923"/>
    <dbReference type="HOGENOM" id="CLU_014393_4_1_1"/>
    <dbReference type="OMA" id="PDFQPFE"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24000">
        <property type="entry name" value="ASKHA_NBD_HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF24">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hexokinase_1"/>
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                <person name="Lin M.F."/>
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                <person name="Sakthikumar S."/>
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                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
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                <person name="Brunke S."/>
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                <person name="Lin M.F."/>
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</entry>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="115" mass="13416" checksum="642EE9C3217AF4DF" modified="2010-10-05" version="1">MLRREATTIRLSPEDILEYDDSVAQQQKQKQELQQGQEQSIPQQNPSDFSPPNILQEQINNSSHSIIPDFKEESGSIYQRSRVSQQQQQQQSQSQSHHHQQQSRDERIGIQRNHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSR9</accession>
    <name>C4YSR9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase</fullName>
            <ecNumber evidence="4">4.1.3.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">tRNA wybutosine-synthesizing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAWG_05138</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TYW1 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="4"/>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSR9"/>
    <dbReference type="PaxDb" id="5476-C4YSR9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05138"/>
    <dbReference type="HOGENOM" id="CLU_007952_1_2_1"/>
    <dbReference type="OMA" id="FHVNGKW"/>
    <dbReference type="OrthoDB" id="271553at2759"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000196">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930:SF0">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE TYW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01071">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="18">
        <location>
            <begin position="150"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="19">
        <location>
            <begin position="426"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="767"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEQ46772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="786" mass="89914" checksum="24754D120B26C681" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSS3</accession>
    <name>C4YSS3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA methyltransferase 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_05142</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSS3"/>
    <dbReference type="PaxDb" id="5476-C4YSS3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05142"/>
    <dbReference type="HOGENOM" id="CLU_776378_0_0_1"/>
    <dbReference type="OMA" id="FKEISWT"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF18">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="7">
        <location>
            <begin position="66"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ46776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="379" mass="44638" checksum="AAEEB6C17D4007F9" modified="2009-07-28" version="1">MIWNTYKYIPLRRQGRQYLFTTNYHLQQLRFKSFRTIDLTFGSHNHNNIPNKRNEKIFFYNYDNTSKIKALDRQFKILNKSQTKILELGFIPSNWLIYIRDTMAKLHNISDPGKIHQKCHILGFDILFGSPPIGVSSIQGNIFSKLAHKNIINHFKEISWTQLRDKRQLESDIDPKSYFSREQDESMIIDKQIERIEAGLKNITMSDIKRQQLLDKRDSLLPDYRIDLILSDLSKPGYQQSGFYDLTETNPYHRYNNNKGLNHSILQPGKSNFEFLDAALLLSCDLLRPGGKFVARLNEIDPYDPEMYLLHEKLEKVFNDVLEIRNFGHTTATTTTTTITTNNNDNDMSFSVQPPIEKYYICNDKKNDDEYDLYDIFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YST6</accession>
    <name>C4YST6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_05155</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the clathrin heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YST6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05155"/>
    <dbReference type="HOGENOM" id="CLU_002136_0_0_1"/>
    <dbReference type="OMA" id="HCYDLLH"/>
    <dbReference type="OrthoDB" id="2113814at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000001">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000002">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000005">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000082">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.730:FF:000007">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.110:FF:000003">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015348">
        <property type="entry name" value="Clathrin_H-chain_linker_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016341">
        <property type="entry name" value="Clathrin_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09268">
        <property type="entry name" value="Clathrin-link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13838">
        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002290">
        <property type="entry name" value="Clathrin_H_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50989">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clathrin heavy chain linker core motif" evidence="9">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="539"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="688"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="835"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="981"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1130"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1276"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1425"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1624"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1624"/>
            <end position="1633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ46789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1671" mass="189547" checksum="C0205481176DFA36" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSW9</accession>
    <name>C4YSW9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSW9"/>
    <dbReference type="PaxDb" id="5476-C4YSW9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05664"/>
    <dbReference type="HOGENOM" id="CLU_099559_0_0_1"/>
    <dbReference type="OMA" id="NHCLIAN"/>
    <dbReference type="OrthoDB" id="4084730at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="222" mass="24881" checksum="4DB6E8270683DB3C" modified="2009-07-28" version="1">MLRSIIKSFKPSASFSSSIISPKSTTSLSTSSLKPLTVYHNSNLLVSHQLVAKLNNFNSTTDSPTNNKITFNLKTNEQLSESDYKFIIDECLYIHPDNKSILLQIFHNKYHMDKKKLIKDFTLHDSIFEYNNLINNNKSYPLIIDYNHCLIANDDASFDRIMMNYLTCGIQNTTSSNSTTASHGFTTNGNSSSSGNGGNNSTGTVKYNDLVHPHMAEFADLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT57</accession>
    <name>C4YT57_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_05756</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT57"/>
    <dbReference type="PaxDb" id="5476-C4YT57"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05756"/>
    <dbReference type="HOGENOM" id="CLU_069210_0_0_1"/>
    <dbReference type="OMA" id="YRIRTHI"/>
    <dbReference type="OrthoDB" id="342981at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000082">
        <property type="entry name" value="t-SNARE (ER)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019529">
        <property type="entry name" value="Syntaxin-18_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10496">
        <property type="entry name" value="Syntaxin-18_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="214"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ47193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="306" mass="35975" checksum="8AB6E592C6DBFE7F" modified="2009-07-28" version="1">MTDLTPLFRQCVDIVQQEYKTSPTTAKQPYYLNDTFIKETTDFFHVLTNLNQFINETKSSYLAINDDTKLAGSIDDKNKIDEEFNYKVQQMYKRLNHLETYETKRQSLLPKTSGWFSFLDEPNDQDIYFETLANHRMQILRFLMETLNHVNKRFENIQQKRLARERQLNLLNFQNFEDGEELEDVFTTLDQIQQVPELSQQQTQQLETENQEFLNMKTSQLKQVEKVQQSILDIVNIQNELAFKLQDQGQQIESLMDSHADVQTEVQMGNRTLSQATKKNKRGANMLVMLCIVLGVLLVLVDYVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTP9</accession>
    <name>C4YTP9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTP9"/>
    <dbReference type="PaxDb" id="5476-C4YTP9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05544"/>
    <dbReference type="HOGENOM" id="CLU_132733_0_0_1"/>
    <dbReference type="OMA" id="CMIERCL"/>
    <dbReference type="OrthoDB" id="4074735at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020233">
        <property type="entry name" value="Slm4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16818">
        <property type="entry name" value="SLM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="203" mass="22478" checksum="2174CE44B88ACF6E" modified="2009-07-28" version="1">MLQQKQISKILQQGLTPITLNSKSNSQSATPIPTSTHSIKSISLLSKQGIPLITVSSTTDSGSGIIDQDYKIYSIIAYNSLNKPNENDNDNDNDNSKNTNKLKSKENETWTIIQFEPGLKCMIERCLDMYLVLYYDGRVDNKDRDAGTDNKNNKLEGAANGDAGDVKTKETRQLEVEVDAFVKLKMDGLVSSLHDGLLGYNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTQ4</accession>
    <name>C4YTQ4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Allantoate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_05549</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTQ4"/>
    <dbReference type="PaxDb" id="5476-C4YTQ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05549"/>
    <dbReference type="HOGENOM" id="CLU_001265_2_2_1"/>
    <dbReference type="OMA" id="TFVAMLQ"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000247">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF29">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ46995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="65802" checksum="B922BB105F82C0BB" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTW5</accession>
    <name>C4YTW5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_05611</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="SMR" id="C4YTW5"/>
    <dbReference type="PaxDb" id="5476-C4YTW5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05611"/>
    <dbReference type="HOGENOM" id="CLU_004760_1_2_1"/>
    <dbReference type="OMA" id="TTMRETE"/>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
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        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF38">
        <property type="entry name" value="CHITIN SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="661"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="736"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="998"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="9">
        <location>
            <begin position="268"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="32"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
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        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ47056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1026" mass="116169" checksum="EA936AE60949644C" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCR9</accession>
    <name>C4YCR9_CANAW</name>
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        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_00303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00303"/>
    <dbReference type="HOGENOM" id="CLU_148322_0_1_1"/>
    <dbReference type="OMA" id="MKIYCAR"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000155">
        <property type="entry name" value="Ubiquitin-like protein SMT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rad60/SUMO-like_dom"/>
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    <dbReference type="InterPro" id="IPR000626">
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    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="24"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ42105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="102" mass="11149" checksum="FDD8427C2B3A2FE1" modified="2010-10-05" version="1">MSDTENTGGSPPAAEAGPKEEKGTHINVKVSDGTQEVFFKVKRNTKFRRLMEAFAKRQGTSPDTMRFLVDGGRVHADQTPEDLDMDDGDTIEAHRAQIGGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD19</accession>
    <name>C4YD19_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase I subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD19"/>
    <dbReference type="PaxDb" id="5476-C4YD19"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00407"/>
    <dbReference type="HOGENOM" id="CLU_090034_0_0_1"/>
    <dbReference type="OMA" id="HFPTGYG"/>
    <dbReference type="OrthoDB" id="4089784at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="6.20.250.70:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase I subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013240">
        <property type="entry name" value="DNA-dir_RNA_pol1_su_RPA34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053263">
        <property type="entry name" value="Euk_RPA34_RNAP_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28155">
        <property type="entry name" value="ACR243WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28155:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34.5-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08208">
        <property type="entry name" value="RNA_polI_A34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="27396" checksum="6DDE89F2F6CC2F10" modified="2009-07-28" version="1">MAPSYKSSEYIDDSDSELSAEEREYEPPKNFQKVTPESKEFSSNLKGKEVWLIKTPKGFPLTDLKKLPISFSGKSAESFKVNNLSYQVTEDLGASASDTNNKHTIFSSKKRSFRPLGEKISRFYSIHEVVDIPEIQLDKVVVPRRNVPKIKKLRMRHFPTGYGAEDYQFDKEEEEEEEESENDDVEAGKVLKKAKVEEKEEKEVKHKKDKKEKKDKKDKKDKKDKKDKKKSKKEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDG2</accession>
    <name>C4YDG2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate dehydrogenase assembly factor 2, mitochondrial</fullName>
            <shortName evidence="4">SDH assembly factor 2</shortName>
            <shortName evidence="4">SDHAF2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_00556</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with the flavoprotein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SDHAF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDG2"/>
    <dbReference type="PaxDb" id="5476-C4YDG2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00556"/>
    <dbReference type="HOGENOM" id="CLU_103054_0_1_1"/>
    <dbReference type="OMA" id="YGKPQNP"/>
    <dbReference type="OrthoDB" id="284292at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.250:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase assembly factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="entry name" value="Flavinator of succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03057">
        <property type="entry name" value="SDHAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028882">
        <property type="entry name" value="SDHAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469">
        <property type="entry name" value="PROTEIN EMI5 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="YgfY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ42348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="155" mass="18281" checksum="20868408B95C6B69" modified="2010-10-05" version="1">MLSKSYRAISKRSFSQSSVVFANYGKPQNPPIDTEIKLKIQPIVRTGETIEVKRARLLYQSRKRGILESDLLLSRFADKYLKTMTMEELDEYDKLLDEADWDIYYWATKNYKITPLPDKWKDSKILKEIQKIANNDEKVIMRMPELNLEPESNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDJ0</accession>
    <name>C4YDJ0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hcy-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_00585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDJ0"/>
    <dbReference type="PaxDb" id="5476-C4YDJ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00585"/>
    <dbReference type="HOGENOM" id="CLU_004914_3_2_1"/>
    <dbReference type="OMA" id="TECYEAQ"/>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008898">
        <property type="term" value="F:S-adenosylmethionine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033528">
        <property type="term" value="P:S-methylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.330:FF:000017">
        <property type="entry name" value="S-adenosylmethionine-homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051486">
        <property type="entry name" value="Hcy_S-methyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007020">
        <property type="entry name" value="PRK09485.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015:SF1">
        <property type="entry name" value="HOMOCYSTEINE S-METHYLTRANSFERASE-LIKE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015">
        <property type="entry name" value="ZGC:172121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ42376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="311" mass="34314" checksum="3FFECAC35FD4C02D" modified="2009-07-28" version="1">MGRVQDILEKRKLVIDGALGTELERLLPTTSTYLPSGSPLWSGQVLITNPELVEQVHLDYINAGADMIITSTYQTSYASLHKYIGYDMDQAIALWNSALNVAKNAVKKSGRDDVIIAGSIGPYATLLANGSEYNGDYQGVTDEELIEYHTPLFEFYENSDVDIICIETIPSFQELKVIIGLAKKYTSKEFFISINPQTGSALSDGTSLIEVAQLFAEINDPRFVAVGINCTSYENVDQISTYLTDFPLFIYPNLGFVYDTTVHKFVSKALQESTWSKSVAKWLAFPNVKAIGGCCSTTPAEIKQVAQLINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDP2</accession>
    <name>C4YDP2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-T/Histone H4 histone fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_00639</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDP2"/>
    <dbReference type="PaxDb" id="5476-C4YDP2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00639"/>
    <dbReference type="HOGENOM" id="CLU_392367_0_0_1"/>
    <dbReference type="OMA" id="YLKFFCK"/>
    <dbReference type="OrthoDB" id="4077024at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22920">
        <property type="entry name" value="HFD_CENP-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="6">
        <location>
            <begin position="656"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="63"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="294"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="358"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ42428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="756" mass="84875" checksum="DED8CAB310F859CD" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDT5</accession>
    <name>C4YDT5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein STU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_00683</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLASP family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDT5"/>
    <dbReference type="PaxDb" id="5476-C4YDT5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00683"/>
    <dbReference type="HOGENOM" id="CLU_261691_0_0_1"/>
    <dbReference type="OMA" id="AKECYWC"/>
    <dbReference type="OrthoDB" id="46159at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060172">
        <property type="term" value="P:astral microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF9">
        <property type="entry name" value="CLIP-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
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</entry>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Sakthikumar S."/>
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                <person name="Forche A."/>
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        </source>
    </evidence>
    <sequence length="354" mass="39783" checksum="C6FD30D10FE83B1C" modified="2009-07-28" version="1">MELTVDNTNTTSNIDDLSVATPTSLMTSTTTSPSISTSTSSHSNTLDIDPATFKSTLPPRKRAKTQEEKEQRKIERILRNRRAAHASREKKRKHVEYLENYVLKLETNLMKLNNNYNQAFELLTKDNQELLLSKLEVLDDVSDLKEQIHSNMSGTRRSHNKKSNDEDIEEEDEDEHQEEGHVEKQEIKKEEPVSKKRKLNTKTKSKTKSSNKTMTSTPSSSVSSLSPDVTNFSGTNTTMSSPIQIKKEFNIDNIFIKKEFSQSPLQPTHQPEQQEQQHEIYLKSESKDAFWNYPSPLSFHDSPLQIDIDTSSSSTSPSSSSSLISSSGPTNHSIADLAAISLASRANRIISVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEC0</accession>
    <name>C4YEC0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">26S proteasome regulatory subunit 7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_00875</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEC0"/>
    <dbReference type="SMR" id="C4YEC0"/>
    <dbReference type="PaxDb" id="5476-C4YEC0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00875"/>
    <dbReference type="HOGENOM" id="CLU_000688_6_0_1"/>
    <dbReference type="OMA" id="RSKYHIE"/>
    <dbReference type="OrthoDB" id="1937997at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000440">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="219"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ42656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="444" mass="49814" checksum="7E999D285AE7D18E" modified="2010-10-05" version="1">MPPKEDWDKYIPPSEEETSEKITPLTEGDIQVLKTYGTAPYADSLKEIEKDLKTIEERIKTNQGIKESDTGLAPPHLWDVLGDKQRMQEEQSLQVARCTKIIEASQPQQPTGLQNADTKSKYVINIKQIAKFVVGLGERLSPTDIEEGMRVGVDRHKYEIQLPLPPRIDPSVTMMTVEEKPDVTYSDVGGCKEQIEKLREVVELPLLSPERFVKLGIDPPKGILLYGPPGTGKTLCARAVANRTDATFIRVIGSELVQKYVGEGARMVRELFEMARTKKACIIFFDEVDAIGGARFDDGAGGDNEVQRTMLELITQLDGFDPRGNIKVMFATNRPNTLDPALLRPGRIDRKVEFSLPDLEGRANIFRIHSKTMSVEKDIRWELISRLCPNATGAELRSVCTEAGMFAIRARRKVANEKDFLKAVDKVIKGNLKFSSTSQYMQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEC6</accession>
    <name>C4YEC6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidyl synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_00882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEC6"/>
    <dbReference type="PaxDb" id="5476-C4YEC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00882"/>
    <dbReference type="HOGENOM" id="CLU_030880_1_0_1"/>
    <dbReference type="OMA" id="WPFHDLT"/>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF57">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ42662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="44932" checksum="FABF4824FFAD955B" modified="2010-10-05" version="1">MLIRRLPIIPTRAIPRISYSQFHTTVVNLNKRITGCDHKGHDFAFVFDIDGVLIRGKKPILQAKPALEILNSHKIPYILMTNGGGVSERRKAEEVSEITQLNPPISPLQIVQSHTPLKALALHHAFNRVLVLGGDGDNARHVAKQYGFQDIIMPIDIVYNNPSVSPHHRYTQEEFDKFAQPIDVTKPIEAIFVLNDPRDLNSDMQIVQDLLNSENGLIGTKRNIHHNRNLHDPSIPIIFSNNDYVYANDYPLPRFGQGAFRIITERLYKITNGLKKHQHLNSLILGKPFKIQYDFAHHVLIDWQNKLINEDFNSEQILPILGSEPTNTPFKKIYMVGDNPASDIKGANDHGWESVLLKTGVYRDEDAIDTEAAKPTAGIFNNVEDAVITILESHGIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEF4</accession>
    <name>C4YEF4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MRH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_00911</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="SMR" id="C4YEF4"/>
    <dbReference type="PaxDb" id="5476-C4YEF4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00911"/>
    <dbReference type="HOGENOM" id="CLU_2014932_0_0_1"/>
    <dbReference type="OrthoDB" id="4504960at2759"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028927">
        <property type="entry name" value="Man-6-P_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF0">
        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02157">
        <property type="entry name" value="Man-6-P_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ42690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="123" mass="14005" checksum="0B959B6BEC7E5C0D" modified="2010-10-05" version="1">MGKYSTVPKFRGRKLTLTYENGSYCDIIDKNTNQRLRKSTILTFTCDREMSARASVSYIGQANECTYFFEVRSHHACPTAAKANNLAAVWIFLFIFLAAVFVYFSGGLLYRQMKQASTTRSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEI0</accession>
    <name>C4YEI0_CANAW</name>
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            <fullName evidence="4">Chl4p</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00937"/>
    <dbReference type="HOGENOM" id="CLU_031572_0_0_1"/>
    <dbReference type="OMA" id="HPASLRW"/>
    <dbReference type="OrthoDB" id="6585699at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF05238">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ42716.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="53176" checksum="DC74CDCB37EE1F92" modified="2009-07-28" version="1">MSKLEQQTPSYKNILPNTYVPYLGHKVLYNILDRLSKNSILQFIILWTKLKNTQPKPPSKYTQHGFNKKITKEVSEFRKSINRTPKRKLIDKIIFEYWTQGLNLLQISQIDCQLIVDKSNSAQSWIYSTVKDMHDKIVPISINPREFLNNLVKNLSSLYLSYIYICKHPKLPIILIRIQVFDLNGMDITEKPHIISHKAYFFGIFVNSPHVVHSINNDAMVHGIVMEAFERSLPQSKNNLLKLITPEDQFPVKSIQSMHILKGCNRSGNSLGIWTPYADGTVDMLPLGAIEDHQVFKSEAEIDEEINETEDVDNLKLQRLKKIANLRFKGSLTGNKQSSSEEPNHHQQQQQPEQDSNLDQTEREGQTNDTEFDSIAPIQYAEFILKEKTIATRTEKSIGDDGRTNIKFKITGSDVFGGLHELSVKSTEPEEIILNPEEVPNWLTGEEGASIGEIRNGNFYNKING</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEJ2</accession>
    <name>C4YEJ2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_00949</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
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                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YEJ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00949"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_11_1"/>
    <dbReference type="OMA" id="SAYPRWG"/>
    <dbReference type="OrthoDB" id="153074at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05367">
        <property type="entry name" value="SPR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000281">
        <property type="entry name" value="Uncharacterized oxidoreductase YIR035C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF8">
        <property type="entry name" value="BENZIL REDUCTASE ((S)-BENZOIN FORMING) IRC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ42728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="28549" checksum="BA38815F5B785FEE" modified="2009-07-28" version="1">MNKIYDVETSNLNFSTNSNKGIGKAIAEILLKTPSSKVVIVARSQAPLESFQKQHGSDRVAFVAGDITDPATSKIAVETAISKFGQLNAVIANAGVLDPIGPIENTSVDQWKQLYDINVFSVVELIKHSLPHLKKTNGKVIGVSSIAAFTAFNGWYAYGSSKAALNHLMYSLASEEKEIQAIAVAPGVVDTEMQNDIREKFGKDMKEEALQQFVDLHKNEKLVSPEEPGTVYANLALKGWSEDLNGKYLDFDDALLKDYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C4YET9</accession>
    <name>C4YET9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Polyadenylate-binding protein</fullName>
            <shortName evidence="14">PABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_01047</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YET9"/>
    <dbReference type="SMR" id="C4YET9"/>
    <dbReference type="PaxDb" id="5476-C4YET9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01047"/>
    <dbReference type="HOGENOM" id="CLU_012062_22_4_1"/>
    <dbReference type="OMA" id="QQPGFMP"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12378">
        <property type="entry name" value="RRM1_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12380">
        <property type="entry name" value="RRM3_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1900.10:FF:000008">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000003">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000211">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000384">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000385">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034364">
        <property type="entry name" value="PABP_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01628">
        <property type="entry name" value="PABP-1234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 13 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="52"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="140"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="233"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="336"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="17">
        <location>
            <begin position="537"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="503"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="505"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ42825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="629" mass="70418" checksum="0B375DF3980C10D9" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF04</accession>
    <name>C4YF04_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Plasma membrane proteolipid 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_01113</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF04"/>
    <dbReference type="PaxDb" id="5476-C4YF04"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01113"/>
    <dbReference type="HOGENOM" id="CLU_107649_6_2_1"/>
    <dbReference type="OMA" id="VHAIWVI"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF42">
        <property type="entry name" value="UPF0057 MEMBRANE PROTEIN ZK632.10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ42890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="57" mass="6291" checksum="FA799F5A71176DE2" modified="2009-07-28" version="1">MPFTCSDIIKIIVAIILPPLGVFLERGCSSSLFINILLTILGYIPGIIHALYVILKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF33</accession>
    <name>C4YF33_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha-1,6-mannosyltransferase MNN11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_01144</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF33"/>
    <dbReference type="PaxDb" id="5476-C4YF33"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01144"/>
    <dbReference type="HOGENOM" id="CLU_021434_1_0_1"/>
    <dbReference type="OMA" id="IKTYNHF"/>
    <dbReference type="OrthoDB" id="205108at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000382">
        <property type="entry name" value="Alpha-1,6-mannosyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF10">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ42919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="51713" checksum="4853F42A17801FB7" modified="2009-07-28" version="1">MFGVGKSGTFKPKYGKNNPSSTSFLPLPATFHQINRKKRLPLILIVLFIIWYIFFNSFLSPFSYLFSKSISKIHYPRAHPLTSTQLIETSSKYIYPPIEHAPLLKQLTTRKLFIEHTYKENGIDKTGIKSLNFLDDPHENLQKAKEKEENDNSPLNAAKNYFKNQDKIVFKPKSGSSSSSSSSSKYPELVIVTAVDFNKYSLDGLTKIVQNRVDYAHLQNYGVYVRWSEEFLPILNNFQYLEDKERAKWIRVYCMKAAMFAFPKTKWFWYLDENGLIMNMNINIHDYMLKPEILNSIMLRDLPLIPPDGIIKTYKNARADSIRFILTQSNQKIETNSFLMKNDYIGKSMIDIWGDNLFFQYPNFPYGPDSALTHILQWHPFILSKTTIVPIKTIAASHKFKDNGLPGNSIYEDGDFVAQWSDCNNPTECENILNIYYNKLKKTPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFE2</accession>
    <name>C4YFE2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exosome complex exonuclease RRP40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_01259</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFE2"/>
    <dbReference type="PaxDb" id="5476-C4YFE2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01259"/>
    <dbReference type="HOGENOM" id="CLU_069847_1_0_1"/>
    <dbReference type="OMA" id="SYMAFPN"/>
    <dbReference type="OrthoDB" id="340500at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000127">
        <property type="entry name" value="Exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000139">
        <property type="entry name" value="Exosome complex exonuclease subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041054">
        <property type="entry name" value="Rrp40_N_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18311">
        <property type="entry name" value="Rrp40_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Exosome complex exonuclease Rrp40 N-terminal" evidence="6">
        <location>
            <begin position="23"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="158"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ43028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="270" mass="29882" checksum="C23842A24D7CA0ED" modified="2009-07-28" version="1">MSDTIILPGDKLPIDEDISTVKTTIGPGIYKKPKTQELIPSAAGILHYERAKSSSQQLIYIESNSKRYIPHTNDYVIGIITGAIGESYKVSLQSNSTPVLLSFWAFPNASKKNRPNLKNGQAVYARVSQDIPEIETELECIDPTSGKEGGFGVLDESGYIFDVHLNFARELLFNPKTIFLETLATRCQFEIAIGINGKIWIKCGNGVKKEANDGSNNNQDQGEDQEMIDVSEENLKDLKSTLAAATFLTRCQFVTQDKLKQELNNAFQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFH9</accession>
    <name>C4YFH9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Protein ROT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_01297</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for normal levels of the cell wall 1,6-beta-glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ROT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFH9"/>
    <dbReference type="PaxDb" id="5476-C4YFH9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01297"/>
    <dbReference type="HOGENOM" id="CLU_071622_0_0_1"/>
    <dbReference type="OMA" id="YKPPQML"/>
    <dbReference type="OrthoDB" id="5327821at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007118">
        <property type="term" value="P:budding cell apical bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019623">
        <property type="entry name" value="Rot1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090:SF1">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10681">
        <property type="entry name" value="Rot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017290">
        <property type="entry name" value="ROT1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944175" description="Protein ROT1" evidence="11">
        <location>
            <begin position="25"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ43060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="260" mass="29880" checksum="9A7FADC540AE4FFF" modified="2009-07-28" version="1">MIFSRYFIPIILTLLTSSPLFVDADPNMEELEGTWSSKSNTVFTGPGFYDPVEELLIEPDLPGICYSFTKDGHYEEALYRVKPNPKNHSCAVASVTYQHGKYELLSNGSLVLTPIAVDGRQLLSDPCNSEDPSKSTYTRYVQSTWFKTYQVYVDSYHGRWTLQIYQFDGSKMQPLYLAYKPPVMLPTIALNPTDEASETASTLGSVSHKIKRSRMRIKRSLENQYRTNAKREIYTEKFDKIWWSSVFCLALASSYFFLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFP6</accession>
    <name>C4YFP6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">oxaloacetate tautomerase</fullName>
            <ecNumber evidence="10">5.3.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_00022</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Tautomerase that converts enol-oxaloacetate, a strong inhibitor of succinate dehydrogenase, to the physiological keto form of oxaloacetate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>oxaloacetate = enol-oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:16021"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17479"/>
            <dbReference type="EC" id="5.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:16023"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.2" evidence="10"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFP6"/>
    <dbReference type="SMR" id="C4YFP6"/>
    <dbReference type="PaxDb" id="5476-C4YFP6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00022"/>
    <dbReference type="HOGENOM" id="CLU_028458_5_0_1"/>
    <dbReference type="OMA" id="NCRKVIC"/>
    <dbReference type="OrthoDB" id="74910at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000014">
        <property type="entry name" value="Uncharacterized mitochondrial hydrolase FMP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="12">
        <location>
            <begin position="11"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ41835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="231" mass="25761" checksum="01CD7FD2B9710463" modified="2010-10-05" version="1">MSLKYLDTARKILCIGRNYAAHIKELNNATPQQPFFFLKPSSSVLKPDSGPFLVPKGVIVHHEVELAFTLNKDLKNLPSTFSPEEAIDSIEGYALTIDMTARNVQDEAKKKGLPWSIGKGFDTFLPVSKFIAKEKIPDPYKVELVLKINGEVKQQDKTDLMLFPIHKILSHMSAIMTLEKGDLILTGTPKGVGQVKPGDKVEAQLLVNGKVIEEIKFDAEEKPGPYEYKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG28</accession>
    <name>C4YG28_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cysteine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_00144</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="2"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YG28"/>
    <dbReference type="PaxDb" id="5476-C4YG28"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00144"/>
    <dbReference type="HOGENOM" id="CLU_013528_3_1_1"/>
    <dbReference type="OMA" id="FHNDMKS"/>
    <dbReference type="OrthoDB" id="438179at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1910">
        <property type="entry name" value="Cysteine-tRNA ligase, C-terminal anti-codon recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="12">
        <location>
            <begin position="61"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="677"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ41952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="781" mass="89773" checksum="10DC96B8B9015BEA" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGH6</accession>
    <name>C4YGH6_CANAW</name>
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        <recommendedName>
            <fullName evidence="11">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="11">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_03153</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Polyol metabolism; glycerol degradation via glycerol kinase pathway; glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="11"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGH6"/>
    <dbReference type="PaxDb" id="5476-C4YGH6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03153"/>
    <dbReference type="HOGENOM" id="CLU_015740_3_1_1"/>
    <dbReference type="OMA" id="PHIVKPM"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.870:FF:000005">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000037">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="12">
        <location>
            <begin position="69"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-glycerophosphate oxidase C-terminal" evidence="13">
        <location>
            <begin position="474"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ44858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="650" mass="72488" checksum="B7357A28F434CE7D" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGL2</accession>
    <name>C4YGL2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxisomal trans-2-enoyl-CoA reductase</fullName>
            <ecNumber evidence="13">1.3.1.38</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CAWG_03191</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in chain elongation of fatty acids. Catalyzes the reduction of trans-2-enoyl-CoAs of varying chain lengths from 6:1 to 16:1, having maximum activity with 10:1 CoA. Has no 2,4-dienoyl-CoA reductase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>(2E)-decenoyl-CoA + NADPH + H(+) = decanoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:44960"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61406"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:44961"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2E)-dodecenoyl-CoA + NADPH + H(+) = dodecanoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:44964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57330"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:44965"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2E)-hexenoyl-CoA + NADPH + H(+) = hexanoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:44956"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:44957"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(2E)-octenoyl-CoA + NADPH + H(+) = octanoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:44952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62242"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:44953"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2E)-tetradecenoyl-CoA + NADPH + H(+) = tetradecanoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:44968"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61405"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:44969"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a (2E)-enoyl-CoA + NADPH + H(+) = a 2,3-saturated acyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:33763"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.1.38"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:33764"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with PEX5, probably required to target it into peroxisomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.3.1.38" evidence="13"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGL2"/>
    <dbReference type="PaxDb" id="5476-C4YGL2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03191"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_1"/>
    <dbReference type="OMA" id="AINYWEE"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019166">
        <property type="term" value="F:trans-2-enoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033306">
        <property type="term" value="P:phytol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052388">
        <property type="entry name" value="Peroxisomal_t2-enoyl-CoA_red"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24317">
        <property type="entry name" value="PEROXISOMAL TRANS-2-ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24317:SF7">
        <property type="entry name" value="PEROXISOMAL TRANS-2-ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EEQ44894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="262" mass="28504" checksum="15B3CCEB92EB239B" modified="2009-07-28" version="1">MSYNLANKIAIVTGGLTGIGLATTIKLLKQGSKVIVGDFLHEHEIDTVLNHIHKQVPKNNRNIKFLRINIANYQDNVNLVDFALDEYSDLHYVVTNTAITTTTATASNKTETIDQFKDMIDTNLNGVFALNKLAINYWEEFHKPGSIVNVSNILGLTTTKGLASYRVCQGGVQSLTQSLALAYANKDIRLNSVIPGYVKISPMLGQINQHIATTAIKQHPMARLGNPDEIANAIAFLLSDEASFVNGTSLVVDGGYSAQMGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGN7</accession>
    <name>C4YGN7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGN7"/>
    <dbReference type="PaxDb" id="5476-C4YGN7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03217"/>
    <dbReference type="HOGENOM" id="CLU_118655_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="199" mass="21941" checksum="233D935D438C81C7" modified="2009-07-28" version="1">MRRQLDNDCESDNSLTNCSLINFLILGTVLLTYHTVKLPLMSTTATFSSSLELKRTSASTFPAKQSADISPKTNSTTFGITSIYVSLSRQMFKMYTLAPVRTATNPTPSILSETSICNIGSQKSIWYAGDSTIQSSFDSYVVIFKIDRDSPVTNVIRSTYASSDLTKISNVCKRSPCIGSYAMLEVKDLDSNMYARIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGS8</accession>
    <name>C4YGS8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_03260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGS8"/>
    <dbReference type="PaxDb" id="5476-C4YGS8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03260"/>
    <dbReference type="HOGENOM" id="CLU_156033_0_0_1"/>
    <dbReference type="OMA" id="QGFLWTG"/>
    <dbReference type="OrthoDB" id="2430343at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140580">
        <property type="term" value="F:mitochondrion autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013898">
        <property type="entry name" value="Atg43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699:SF1">
        <property type="entry name" value="MITOPHAGY RECEPTOR ATG43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ44960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="153" mass="17490" checksum="2CD7A0757BCC0E0C" modified="2009-07-28" version="1">MSLPIPDLRFEQSFISQLNKYAGNKQPDQQKLQPLSSKKYNHIATLTDDDLKLMNEELDIEEEEEIDNYTDKPQPKPLAPITPSIVIYAIIKDQMLMPLLQGFLWTGVLLCVRPLLKLVVRNGQYAGHWVSNLLGLNRLATSRSSLHSRRSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH63</accession>
    <name>C4YH63_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HotDog ACOT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_03404</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YH63"/>
    <dbReference type="PaxDb" id="5476-C4YH63"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03404"/>
    <dbReference type="HOGENOM" id="CLU_032862_1_0_1"/>
    <dbReference type="OMA" id="RAESHNA"/>
    <dbReference type="OrthoDB" id="331699at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000032">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000038">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655:SF0">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="105"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="316"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ45095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="507" mass="57843" checksum="C5681B23BD4DD6A1" modified="2009-07-28" version="1">MIRLIRQSSIQKFVRPQPQSQLLLRFNSQKINFHKPDKAYSNERSDAADAAATILSELHDEKVHPNKATWLDALKQREKFQAEGKTLDSYSYIDPITTAVGEKTRSDSFSYLILPFKDDKWLCDAYINAFGRLRVGQLFQDLDALAGRIAYRHCSPAEPVNVTASVDRIYMIKKVDEITNYNFVLAGSVTWTGRSSMEITVKGYAFEEEEITHIENEESLSEENVFLSANFTFVARNPLTHKSFAINRLLPVNENDWIDYRRAESHNAKKKLMAKNLSLIEPTPEESKLIYDMWKSSKSLQNDVEKKLNDGIAFMKDTVMKSTLFMQPQYRNRHSYMIFGGYLLRQTFELAYCTAATFSSAGPRFVSLDSTTFKNPVPVGSVLTMNSSISYTEHLHDLDQIKEEIDNDSPFNFSLPPTNKISKSPNAFLSEPGTLIQVKVDTYIQQLEQNDKKPAGTFIYSFFVPKEGNSSFCSVIPQTYSEMMTYIGGRRRAQDTAQYVETLPTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHB0</accession>
    <name>C4YHB0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHB0"/>
    <dbReference type="PaxDb" id="5476-C4YHB0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03455"/>
    <dbReference type="HOGENOM" id="CLU_016174_1_0_1"/>
    <dbReference type="OMA" id="WECDCHE"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47186">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47186:SF61">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 57-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="656" mass="75161" checksum="524F03E4D75FC3AF" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHF6</accession>
    <name>C4YHF6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_03502</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YHF6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03502"/>
    <dbReference type="HOGENOM" id="CLU_000684_1_0_1"/>
    <dbReference type="OMA" id="GEASYMC"/>
    <dbReference type="OrthoDB" id="26387at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16482">
        <property type="entry name" value="RING-H2_UBR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19673">
        <property type="entry name" value="UBR-box_UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000002">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase ubr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="11">
        <location>
            <begin position="106"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="106"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ45188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1898" mass="219215" checksum="06D0DE3298B7E317" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHJ8</accession>
    <name>C4YHJ8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_03545</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YHJ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03545"/>
    <dbReference type="HOGENOM" id="CLU_007571_0_0_1"/>
    <dbReference type="OMA" id="FMPGGYS"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF28">
        <property type="entry name" value="REGULATORY PROTEIN ADR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="34"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="183"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="454"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1134"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1331"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="237"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="462"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1134"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1150"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1331"/>
            <end position="1347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ45230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1409" mass="159072" checksum="4E3B5B0EEDCDBFCE" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHM3</accession>
    <name>C4YHM3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Intradiol ring-cleavage dioxygenases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_03571</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHM3"/>
    <dbReference type="PaxDb" id="5476-C4YHM3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03571"/>
    <dbReference type="HOGENOM" id="CLU_046727_1_1_1"/>
    <dbReference type="OMA" id="AMGPKTT"/>
    <dbReference type="OrthoDB" id="5238185at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03461">
        <property type="entry name" value="1_2-HQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.130.10:FF:000005">
        <property type="entry name" value="Catechol 1,2-dioxygenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039390">
        <property type="entry name" value="1_2-HQD/HQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF7">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00083">
        <property type="entry name" value="INTRADIOL_DIOXYGENAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="7">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ45255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="303" mass="33786" checksum="51BA9A50612DBFBA" modified="2009-07-28" version="1">MSQAFTESVKTSLGPNATPRAKKLIASLVQHVHDFARENHLTTEDWLWGVDFINRIGQMSDSRRNEGILVCDIIGLETLVDALTNESEQSNHTSSAILGPFYLPDSPVYPNGGSIVQKAIPTDVKCFVRGKVTDTEGKPLGGAQLEVWQCNSAGFYSQQADHDGPEFNLRGTFITDDEGNYSFECLRPTSYPIPYDGPAGDLLKIMDRHPNRPSHIHWRVSHPGYHTLITQIYDAECPYTNNDSVYAVKDDIVVHFEKVDNKDKDLVGKVEYKLDYDISLATESSIQEARAAAKARQDAEIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHW2</accession>
    <name>C4YHW2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHW2"/>
    <dbReference type="PaxDb" id="5476-C4YHW2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03665"/>
    <dbReference type="HOGENOM" id="CLU_1578313_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="169" mass="20730" checksum="17CBD6C50CD54CA1" modified="2009-07-28" version="1">MKKKKWAEIVVLLLFTHPNTYNKWQHKNSTLTAFRFLHFSLSTSTSTSTLIHYIYIYYYYYLLLLLTNHLKFFYIYFYISFFLSLSNLFIFIFFNISLINSTSTYLLIFYKSFDYIHHHPITSFYSQKFFFPYLEILFLYKFGDQKKFINNFFLQPIHPLQSIHLLILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHW9</accession>
    <name>C4YHW9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHW9"/>
    <dbReference type="PaxDb" id="5476-C4YHW9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03672"/>
    <dbReference type="HOGENOM" id="CLU_021934_1_0_1"/>
    <dbReference type="OMA" id="YGFHASI"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF108">
        <property type="entry name" value="DAGKC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="46"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="381" mass="43062" checksum="8EED9C54B985A9E8" modified="2009-07-28" version="1">MTRYRLTYQLKNIALEFGENDGKYFIQSGHSSTGKILNLSTLLSYLTERKVIIIDSVKSGTGRTPGKDIYSDILDPLFKELSIEHEYHATKSATSISELASSLKDHKVTIIFISGDTSINEFINSLNDSEKGEIAIFPIPGGTGNSLSLSLNITNPLDAIIRLFSAGTTSPLNLYEVDFPQGSHYLIANELGSPVPSHLKFLVVLSWGFHASLVADSDTPELRKHGIKRFQLAAHQNLNRDQKYEGDFYINDVELNGPFAYWLVTASQRFEPTFEISPKGDILKDELYVVTFNTQNTQNYIMDIMKEVYDKGSHIKNPNVVYKKLDKNDKIQLKTKNSKPLIQRRFCVDGSIIALPETESHEIYIHVKDNSQHSWKLYIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI07</accession>
    <name>C4YI07_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_03713</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI07"/>
    <dbReference type="PaxDb" id="5476-C4YI07"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03713"/>
    <dbReference type="HOGENOM" id="CLU_002173_2_3_1"/>
    <dbReference type="OMA" id="DCFELQM"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="625"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ45389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="973" mass="113386" checksum="CC56DEF04D90C6EF" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YID1</accession>
    <name>C4YID1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04204</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YID1"/>
    <dbReference type="SMR" id="C4YID1"/>
    <dbReference type="PaxDb" id="5476-C4YID1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04204"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_2_1"/>
    <dbReference type="OMA" id="CERGHHS"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08254">
        <property type="entry name" value="hydroxyacyl_CoA_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="12"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ45866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="349" mass="38012" checksum="BA293622AD01374C" modified="2009-07-28" version="1">MPTQSGYGYVEGYSDIQKFTDIPIPTPKGNEVLLKVEAAGLCLSDPHVLIAGPIESKPPIPLATKFVMGHEIAGSVSAVGEQLVNDPNYKKGARFALQIAKACGMCDSCRKGYDGVCDSSHQAYGLNEDGGFQQYLLVKNLRTLLPIPEGVSFEQAAVTTDSVLTPFHAIQKVRHLLTPTSKVLVQGCGGLGLNAVQILKNYGCYIVASDVKGAVEKLALEYGANEFHTDIGKSKHEPMSFDVIFDFVGIQPTFNNSDKFIKRRGKIVMVGLGRSKLLIPNYKLGIREVEIIFNFGGHSAEQVECMEWVAKGLIKPNVHVADFNSLPQYLEDLANGKLTGRVVFRPNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YII9</accession>
    <name>C4YII9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_04265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YII9"/>
    <dbReference type="PaxDb" id="5476-C4YII9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04265"/>
    <dbReference type="HOGENOM" id="CLU_026673_29_2_1"/>
    <dbReference type="OMA" id="YNNREAS"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF19">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="9"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="2">
        <location>
            <begin position="182"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ45924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="40914" checksum="B6950E572F4EBDB3" modified="2009-07-28" version="1">MSLPSVATQIVLKNHPTGFINPEFNKLDSTFAVKHASFPKELKEGEVIVKTLYLSNDPTQRSWIRSKLEKRRHYAKPIEEGSPMRSLGLGQIVQSNSSRFKPGDTVYGIILWGDYSVLEDTSLYNSIDTSLGLPLEYYLSVLGMTSLTAFFGLTEAGDLKQYLNSPPGKGPIVCVSAASGATGSVVVQIAKNLLGASKVIGISGSSEKCQWVEKLGADICVNYKDPNYQDQIEKFLGNEFIDTYFDNVGGDILSFVLTKVKKFGNVVACGSIAGYNNREASKVSNWGEITVNSLTVRGFIVTDYQEHFPKAIGILTDAVKAGKIRTDGAYHVENLHGHDLIHRLENIPKIWNKLFEDNKPNGKMITKVALDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIL0</accession>
    <name>C4YIL0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_04286</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIL0"/>
    <dbReference type="PaxDb" id="5476-C4YIL0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04286"/>
    <dbReference type="HOGENOM" id="CLU_016922_4_0_1"/>
    <dbReference type="OMA" id="FWGWQAH"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005685">
        <property type="entry name" value="PRK07483.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094:SF1">
        <property type="entry name" value="AMINOTRANSFERASE CLASS-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ45945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="53669" checksum="13E4CF708C78BD9A" modified="2009-07-28" version="1">MTKKYSSTDLKSSKLLHRDLNSPPIVIDHANGNNLFTQDHHQLFDSVGGAAVISVGHNNKEVIDAITTQLQKVSYLHTGEFTVPIAEELAHELINNLDSSSGYSGGDVDPSKKIAKVYFANSGSEANEAAIKLVMQYFYEQGKHTKTQFISRHQSYHGNCLGGMSLSGHIARRKPYESIIDQSRFHKVDPCYEFRYKQSNDESNESSDQYVKRLLEQLENKILQIGPENVAAFFAETIVGATTGCVPATPGYFKGVREICDKYDILLVLDEIMCGSGRTGTFFAWQQEQEGEKGGQSIIPDITTCGKAITSGYCPLSCVFFNKKILDVLSNGSSCFNCGHTYQSFPIACAAAHAVQKIIKRDNLLDNVVKMGVILQELLMMKIDPLEIVANIRGRGLFWGIEFCKNKSTLEPFNPSCNVSTNIGEYTKRNGVVVYPGKGTIDGIKGDHILIAPSFTITKEEIEFIVDIVAKSIKEFIANEVNLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIS3</accession>
    <name>C4YIS3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_04350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ46008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIS3"/>
    <dbReference type="PaxDb" id="5476-C4YIS3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04350"/>
    <dbReference type="HOGENOM" id="CLU_000022_45_4_1"/>
    <dbReference type="OMA" id="EWIVRDS"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="147"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ46008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="717" mass="80336" checksum="3E2C9B9C2D759A98" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIU8</accession>
    <name>C4YIU8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_04377</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ46033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="C4YIU8"/>
    <dbReference type="PaxDb" id="5476-C4YIU8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04377"/>
    <dbReference type="HOGENOM" id="CLU_009646_8_2_1"/>
    <dbReference type="OMA" id="AICYTVC"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF349">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="136"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ46033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="535" mass="58820" checksum="5E6199DC399441F4" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIV8</accession>
    <name>C4YIV8_CANAW</name>
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        <recommendedName>
            <fullName evidence="8">Sphingoid long-chain base transporter RSB1</fullName>
        </recommendedName>
    </protein>
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        <name evidence="10" type="ORF">CAWG_04387</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ATP-dependent translocation of sphingoid long-chain bases (LCBs) from the cytoplasmic site toward the extracytoplasmic side of the membrane (flip-flop). Involved in the establishment of the functional lipid asymmetry of the plasma membrane. Regulates intracellular levels of LCBs, sphingolipid precursors that are growth inhibitory at increased levels.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lipid-translocating exporter (LTE) (TC 9.A.26.1) family.</text>
    </comment>
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        <property type="protein sequence ID" value="EEQ46043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="PaxDb" id="5476-C4YIV8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04387"/>
    <dbReference type="HOGENOM" id="CLU_033465_6_3_1"/>
    <dbReference type="OMA" id="THEWYFI"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="160"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ46043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="453" mass="50962" checksum="37107153E6F44C9C" modified="2009-07-28" version="1">MSEILNYLSSWTPTSTPTSTTLSSIATSHVSKLSQTVASVISQATTETDWYNLRSLSQAYRGAQASLTIISAEKVLATATDSQVQSRATQAIFEATLNLKDLSMEQNIYGYELNRAANIIYLVVYAIIFGYTLLMCIKSKYWWYNVTFVCGYGLEFVGFLGRVLSFNDTSNMSHYIMQSVALTIAPAFIMAGVYFLFGQLVVIHGRQYSVLKPMWYSYFFITADVVSLLIQAAGGGIASVASSNHKDSSVGTNIMIAGIAAQVVAMTIFLVFWFEFLNRLYFKNSRSDLIVDCPYGRRSISNYFKLLLNVKSVRGHRHTHLEKYYNEKFASIRQIPLFDYMVLAMTIAVIVVYIRCVYRVAELAEGWGGYLFTHEPYLMILDAAMIAIAGLIFIPFHPVWVFGKNNIVKLATIKKNLDENEKNQDVEYNDDVESQERSSSVVANDMHCLNSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIY2</accession>
    <name>C4YIY2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NDT80 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_03794</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIY2"/>
    <dbReference type="PaxDb" id="5476-C4YIY2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03794"/>
    <dbReference type="HOGENOM" id="CLU_032654_1_0_1"/>
    <dbReference type="OMA" id="IFYFDRG"/>
    <dbReference type="OrthoDB" id="2288358at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF2">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="248"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="2">
        <location>
            <begin position="248"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="150"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="565"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="191"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ45466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="592" mass="68431" checksum="FAA541791C059BB4" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ24</accession>
    <name>C4YJ24_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_03836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ24"/>
    <dbReference type="PaxDb" id="5476-C4YJ24"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03836"/>
    <dbReference type="HOGENOM" id="CLU_1669145_0_0_1"/>
    <dbReference type="OMA" id="RSSHEGW"/>
    <dbReference type="OrthoDB" id="4022470at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ45508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="158" mass="18291" checksum="CD7451F6F5D4989C" modified="2009-07-28" version="1">MNNSNDWSFSLCDDSLELFDAIEEEVGDNDTTIHPKSDDSNNGDKCTLSNQYNPFILTKMNYFKRKHPKTKSKMFDKKIKVKATDILKNIGSTPPENLNWDFTCSWIHRKGIPTEILKEGFCNRVVNSENYQFIRSRSSHEGWFIATTKKTSRPKSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ55</accession>
    <name>C4YJ55_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_03867</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ55"/>
    <dbReference type="PaxDb" id="5476-C4YJ55"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03867"/>
    <dbReference type="HOGENOM" id="CLU_023194_7_2_1"/>
    <dbReference type="OMA" id="CTSSFRY"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="6"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="152"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ45539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="359" mass="40748" checksum="701294906A48D0FB" modified="2009-07-28" version="1">MTVITLNWGILGAGNISSQFVHDLVLNNQRDTQFHHIVKSIGCSSHDKGLDFIKKNNITLENNFQTTPIVESYEDFYKNSDIDVVYIGTPHTFHKEQSIACLNNNKHVLCEKPVTVNKAELESILNVAKSKKKFFMEAMWTRFFPAITELKKKIYDEKVIGEIHRLFADLSYNCDISNIPLSSRIRNKDLAAGSLLDIGIYPLTYSRVLLDDSLGENHSPFQIKSYLTIDSQDQVDHLYSAIVKYQNGKHAVLTASELIDGPKAYVRLEGSQGHVEMYSDNPARVKHFKIFNAKGDEIFEYKDGSGYNGFIYEANAVAKDITEGKLSNDTMPHDESLLIMETMDQIRHENGLVYPQDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJB4</accession>
    <name>C4YJB4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LNS2/PITP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_03927</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lipin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJB4"/>
    <dbReference type="PaxDb" id="5476-C4YJB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03927"/>
    <dbReference type="HOGENOM" id="CLU_002546_3_1_1"/>
    <dbReference type="OMA" id="QDYSMKL"/>
    <dbReference type="OrthoDB" id="4567at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000063">
        <property type="entry name" value="Nuclear elongation and deformation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057124">
        <property type="entry name" value="Ned1-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24565">
        <property type="entry name" value="Ned1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="4">
        <location>
            <begin position="330"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="543"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="618"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="547"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="623"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="640"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="690"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="771"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ45598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="781" mass="88133" checksum="A74351FE2BB1C291" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJR4</accession>
    <name>C4YJR4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="2 12">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_04083</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="2 12"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJR4"/>
    <dbReference type="PaxDb" id="5476-C4YJR4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04083"/>
    <dbReference type="HOGENOM" id="CLU_000404_1_2_1"/>
    <dbReference type="OMA" id="IELPQHM"/>
    <dbReference type="OrthoDB" id="3000483at2759"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01679">
        <property type="entry name" value="RNR_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.70.20:FF:000001">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="14">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="784"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="796"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="811"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ45748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="854" mass="96240" checksum="9DE45439C00FE81D" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJZ2</accession>
    <name>C4YJZ2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-terminal Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_05784</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
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                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
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                <person name="Brunke S."/>
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                <person name="Hube B."/>
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                <person name="Logue M.E."/>
                <person name="Martin R."/>
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                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
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                <person name="Sherlock G."/>
                <person name="Shah P."/>
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                <person name="Staggs R."/>
                <person name="Stansfield I."/>
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                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
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                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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            <dbReference type="PubMed" id="19465905"/>
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</entry>
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</entry>
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    <sequence length="241" mass="27555" checksum="60485C8AC60B8BCE" modified="2010-10-05" version="1">MSKIPYPRLIFVRHGQTEWSKSGQHTSTTDIDLTPFGVEQMRNTGRALIGPSNLQMIKPENLTRIFVSPRQRAQQTLQLLLEDVDPEFKDKIPVEIDEDVREWDYGDYEGITSAEINELRKKKGLDDKDHKWSIWSDGCEGGEQHYDVAKRLDRFIEKVREFHRQAIAKKEPCDILVVAHGHILRCLGARWVQRELNVNPQLILDAGGVGTLSYEHHNIDEPSIFLSGAFTVPVAEQCADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKI3</accession>
    <name>C4YKI3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKI3"/>
    <dbReference type="PaxDb" id="5476-C4YKI3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05987"/>
    <dbReference type="HOGENOM" id="CLU_041160_0_0_1"/>
    <dbReference type="OMA" id="FNTYTIC"/>
    <dbReference type="OrthoDB" id="4022842at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944288" evidence="2">
        <location>
            <begin position="22"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ47412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="511" mass="58224" checksum="CE5F7B65DCCD68AB" modified="2009-07-28" version="1">MLLKQLIISISLLTSFTFALTSNPTILGFEKGVICGPISQRKGKGYIKVDGSKLPQDFKLPTLIFHYTDLLNFTNLPNVEKYFDDYAKHQISDSLFDDDKSKFNLKVASDFQIDDAKLYNGYIDTNKNVEYIVYDTGIYCVYIGKLEDKKIDIPVVFKNSYGNLTYIEYTIYSQMKYVIVLAIILFIYLLNYILKFKVGKDFKDLDSVSVISKAVIFLVLFPFILVNSYMWIGSFLENNFFDTSKDSMLMNLAKQGAQFLSIAFNTYTICILLLFSMGYGVIYYHNGNSHRYRLFPHQTFVRIVGFFVTNLVVIYIYLLLLNGSKSDTPFLTGFDQLEPPSSGSAVLNLFAGLTGLFSITWFILIVYFYFKTKKTISHFPPNPNDEDSTQRVVLAFKRSILIILILPIIVMFIAGLITASRVVRGIADSLPDYPSGDTVNFDSVIRMLALEKSMEVAVSPLLISNWIYFFSAVIGLFFIWIKDNNGLIIDRNVDDPIENADVSQFNISDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKJ5</accession>
    <name>C4YKJ5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Association with the SNF1 complex (ASC) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_06000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKJ5"/>
    <dbReference type="PaxDb" id="5476-C4YKJ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06000"/>
    <dbReference type="HOGENOM" id="CLU_033562_1_0_1"/>
    <dbReference type="OMA" id="MEQYYVA"/>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140767">
        <property type="term" value="F:enzyme-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000562">
        <property type="entry name" value="Snf1 kinase complex beta-subunit Gal83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="5">
        <location>
            <begin position="288"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="219"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="87"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ47424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="414" mass="46938" checksum="3E9619EAFDC0B17A" modified="2009-07-28" version="1">MLSPKSTNQEAPATAPLDDINTTKDVSMVDVSKAEGENQQPPRRKSTIILTDEIDLDRMNIDNKESDKSNEQGDKMHIDRSLSNLNQQQHSQSSQSEPSQPEQQQSQQQQQQQQQQQQQPVAPDANIAVPVDIKWVQGGQKVYVTGSFTGWRKMIGLVKQPDDNFMITLGLPVGTHRFRFVVDNELRFSDFLPTATDQMGNFVNYIEITPENVQQHLLQEKEESNNESQQQELEKQQAKTGDKTSSQQASRRSSVSRSRSNSMWGLTNDDDDMGDGYSRYHDDESNALDEKTYQYIKDIPPIFTDPKVMEQYYVAIDKQSRNNNGQQQAWLHPPQLPPHLESVILNNFNNTENNSGALPIPNHVVLNHLATTSIKHNTLAVASIVRYKRKYLTQVLYAPLQQASSSSTTQEQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKQ0</accession>
    <name>C4YKQ0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">MIND complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_06056</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mis12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKQ0"/>
    <dbReference type="PaxDb" id="5476-C4YKQ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06056"/>
    <dbReference type="HOGENOM" id="CLU_046437_0_0_1"/>
    <dbReference type="OMA" id="CTQAMET"/>
    <dbReference type="OrthoDB" id="1884855at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008685">
        <property type="entry name" value="Centromere_Mis12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527:SF2">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05859">
        <property type="entry name" value="Mis12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ47479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="36955" checksum="40159971CAC7A0ED" modified="2009-07-28" version="1">MSDKTLDERTTAILTEHLEFAPLTLIDDVINAVNEIMYKGTTAIETYLKEQKQLMKNGIFTKVTEDEIEIGMGKLESLLESTIDNNFDKFELYCLRNIFNIPKDLIPYIQLSHQQGIEFKSDNVEQKREFDQQIKNLQLKIMQELQLRKILKLQLVKVQKLIKVLIAIDNDFKKIDFASGGGGGNEESIRILKNLQPIDETLYFLISQIKNLINQIEQLSNKVNTNLKTQKFIPNLRDKFIDGRTFRVLQQTGIWKDLEKNDIKISVQGNDNNNNNNNNNNNNNNNNTLTDLQNQDDIDMIIPEQDDIDVDAIKNINAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKQ3</accession>
    <name>C4YKQ3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_06059</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKQ3"/>
    <dbReference type="PaxDb" id="5476-C4YKQ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06059"/>
    <dbReference type="HOGENOM" id="CLU_019699_1_0_1"/>
    <dbReference type="OMA" id="ISQCVYY"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098852">
        <property type="term" value="C:lytic vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034486">
        <property type="term" value="P:vacuolar transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000009">
        <property type="entry name" value="PQ loop repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000012">
        <property type="entry name" value="Vacuolar membrane PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF44">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="119"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ47482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="345" mass="39185" checksum="4198203879F91035" modified="2010-10-05" version="1">MSSIVYNMLTTAGSPITTIQPSTWRTQISGVMGSTSLACWIVLLMPQLIEQWRLKSAEGIAIGFITIWFMGDIFNLIGALWAKLLPEVIFLAVWFCIADFLMIFSYVYYTKIYPKHHHQHHHHEHGQGDNEENHHHHHHHHHNKRKSRGNDNESSPLLNTTRSRSSSTGHGDSTHKRTRRRSSTLTDIALEPEYHSIFIKYILPILFVIGCGTLGFFISGTSGENNSPDDNTPPSPPPSDDIIAIGPQVMGYCSALLYLGARIPQIIQNHQRKSVHGLSLLFFLFSTLGNLTYAGQILFYRNDSQYILLNLSWLLGSLGTIFEDSLIFLQFYMYRDNNKDEATVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKU3</accession>
    <name>C4YKU3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_06102</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for assembly of the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKU3"/>
    <dbReference type="PaxDb" id="5476-C4YKU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06102"/>
    <dbReference type="HOGENOM" id="CLU_001485_24_1_1"/>
    <dbReference type="OMA" id="LCTIHMG"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01374">
        <property type="entry name" value="KISc_CENP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000073">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF36">
        <property type="entry name" value="KINESIN HEAVY CHAIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 14" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9 13 14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="17">
        <location>
            <begin position="76"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="424"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="153"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ47522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="665" mass="74902" checksum="6B1CA1D24A0A9BCF" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKV1</accession>
    <name>C4YKV1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ERCC4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_06110</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPF family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKV1"/>
    <dbReference type="PaxDb" id="5476-C4YKV1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06110"/>
    <dbReference type="HOGENOM" id="CLU_002265_2_0_1"/>
    <dbReference type="OMA" id="THILDIM"/>
    <dbReference type="OrthoDB" id="361020at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000736">
        <property type="term" value="P:double-strand break repair via single-strand annealing, removal of nonhomologous ends"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20078">
        <property type="entry name" value="XPF_nuclease_XPF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000002">
        <property type="entry name" value="DNA repair endonuclease XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047520">
        <property type="entry name" value="XPF_nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150:SF0">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="10">
        <location>
            <begin position="731"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ47530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="970" mass="111683" checksum="36BB33A2C3293523" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKX9</accession>
    <name>C4YKX9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_06138</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
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    <dbReference type="PaxDb" id="5476-C4YKX9"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:nucleic acid binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Zn-ribbon_RPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
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        <property type="entry name" value="Zn_ribbon_RPC11_C"/>
    </dbReference>
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        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="13">
        <location>
            <begin position="67"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="5"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="8"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ47558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="111" mass="12671" checksum="F70F9E50A48156EE" modified="2009-07-28" version="1">MLTFCPNCSNMLLISAGDDGLNRFYCSTCPYEFKINGLQMYDRKKLNRKQVDDVLGGEGTWDNVDQTAAQCPIDSCGGDKAYFFQLQIRSADEPMTTFYKCVKCGHRWKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL54</accession>
    <name>C4YL54_CANAW</name>
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        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="N-TERMINAL KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="745"/>
        </location>
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        <location>
            <begin position="565"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="595"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="709"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="745" mass="84113" checksum="8639D0F4477A3AB5" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL56</accession>
    <name>C4YL56_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_01571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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        <lineage>
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            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL56"/>
    <dbReference type="SMR" id="C4YL56"/>
    <dbReference type="PaxDb" id="5476-C4YL56"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01571"/>
    <dbReference type="HOGENOM" id="CLU_091745_0_0_1"/>
    <dbReference type="OMA" id="YWDNLKF"/>
    <dbReference type="OrthoDB" id="4084459at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="158"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ43337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="241" mass="29018" checksum="9F3E7E387833A124" modified="2010-10-05" version="1">MHMTTNPKKHSRSDDDEEDSLHDYSGKRVKLDSLLKNLSLKDQENEKRYIINPKITYENIFSKSGSRYSSFTESQLASNLNEKLTRSFKNVLESGLRLIPWYNSKFLIMYRYQKWFIKLFNRFIKKYNERNRVSISTFHSFADIVKLVRDKLITLEDLANIINQENQLEMKRLELKQEMRRSEKRFEEVTAEQDAYQDLKYNYWDNLKFDKDLDMLDVSDDEPDNLKFEELDDDTVMVQDL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-03-08" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL78</accession>
    <name>CHO2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidylethanolamine N-methyltransferase</fullName>
            <shortName evidence="1">PE methyltransferase</shortName>
            <shortName evidence="1">PEAMT</shortName>
            <shortName evidence="1">PEMT</shortName>
            <ecNumber evidence="1">2.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CHO2</name>
        <name type="ORF">CAWG_01594</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11164"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.1.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.17" evidence="1"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL78"/>
    <dbReference type="PaxDb" id="5476-C4YL78"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01594"/>
    <dbReference type="HOGENOM" id="CLU_005987_0_1_1"/>
    <dbReference type="OMA" id="RIWYSVG"/>
    <dbReference type="OrthoDB" id="4583at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004608">
        <property type="term" value="F:phosphatidylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000016">
        <property type="entry name" value="Phosphatidylethanolamine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03217">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016219">
        <property type="entry name" value="Phosphatid-EA_MeTrfase_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138:SF0">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000383">
        <property type="entry name" value="PEAMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51598">
        <property type="entry name" value="SAM_CHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000405881" description="Phosphatidylethanolamine N-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="85"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="113"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="227"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="283"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="306"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="376"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="492"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="549"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="606"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="889" mass="102629" checksum="F7FFFEC8D31E4384" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-03-23" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL88</accession>
    <name>DRE2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fe-S cluster assembly protein DRE2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Anamorsin homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">DRE2</name>
        <name type="ORF">CAWG_01605</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Interacts with TAH18. Interacts with MIA40.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anamorsin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL88"/>
    <dbReference type="SMR" id="C4YL88"/>
    <dbReference type="PaxDb" id="5476-C4YL88"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01605"/>
    <dbReference type="HOGENOM" id="CLU_067152_0_0_1"/>
    <dbReference type="OMA" id="TMITCGK"/>
    <dbReference type="OrthoDB" id="311633at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11000">
        <property type="entry name" value="Fe-S cluster assembly protein Dre2, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03115">
        <property type="entry name" value="Anamorsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031838">
        <property type="entry name" value="Dre2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16803">
        <property type="entry name" value="DRE2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0001">2Fe-2S</keyword>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000392380" description="Fe-S cluster assembly protein DRE2">
        <location>
            <begin position="1"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal SAM-like domain" evidence="1">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="1">
        <location>
            <begin position="193"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site A" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site B" evidence="1">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 1" evidence="1">
        <location>
            <begin position="374"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 2" evidence="1">
        <location>
            <begin position="385"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="411" mass="46144" checksum="BA9481978C3EFFBC" modified="2009-07-28" version="1">MTSSINILLLLHPTVVTDAQLVEQIKSKIYQSHNNNNNNNGGTTTTTTGTVNINLNQQIIDRVTKGIIELPYDYYDEIIYINPNNESQYREIPISLMQLIYKLLKSNGKFKGDLPLDQNLDVLMTGFIIEEEEKEKEENNLEGELVNVWVKPIPVDEPVVTLLKKKTTTSNTTTKKKSLPLFKKLNKDEINNSDKDINNDNITNNNNNNNNNKRKLVETKLTYFSSDDENSSDGSVSENDDIDDDDELIDENDLLNFNNNNNNNTNGGSLLSDKLITPRKCDISLNGGKKRKKACKDCTCGLKELEELEVSNQQNLQDQILGKLAQSATLEAIKIEERLKQQQQQQQQQKVKVKFTEEDLSEIDFTVQGKTGGCGSCALGDAFRCDGCPYLGLPPFKPGEVVKLDGFGEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLG3</accession>
    <name>C4YLG3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bromodomain associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_01681</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLG3"/>
    <dbReference type="PaxDb" id="5476-C4YLG3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01681"/>
    <dbReference type="HOGENOM" id="CLU_039858_0_0_1"/>
    <dbReference type="OMA" id="NGFDKCK"/>
    <dbReference type="OrthoDB" id="5402929at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00576">
        <property type="entry name" value="BTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="6">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ43444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="364" mass="42313" checksum="076AAAE5CC975A5A" modified="2009-07-28" version="1">MDESFYFALLRISIAQILKANGFDKCKPSTLNVMTDLYLQTFQNAIRESLKCSNMRTNSNSPELQDITQALINISIFKANEATKIHDEYYEESRYNTKSIEAFYQWCKKSEPLAIEKKLNEVPNNLIKNLIEKRKLDIDDGESDLAKRKRKHKERQEFYNQLKLNDDQRHRVDEDELDENVITAKDKLTWLNYLIEKDLKLGHDLKFLHTDPIIAKEFLKFQNNYKFHPVGVRNDKETNTNWDRIQNHLKHLNKTDHIVGEVSPEKVAPNEGDRDILKSLANVSCLLPYNLKYDENLLEEDLTKLTKAEVIQNEEEGINDEHRAPDDEVEQTPNESTLNDGEINNDGLLIDDTGIGGENSLIFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLH6</accession>
    <name>C4YLH6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_01694</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLH6"/>
    <dbReference type="PaxDb" id="5476-C4YLH6"/>
    <dbReference type="HOGENOM" id="CLU_1651919_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ43457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="21822" checksum="CD516C5537967267" modified="2009-07-28" version="1">MRIAINTHDFPSRWFFLFSPLFGVLFCSIFRSTINYLPMSSVSSEKNSGLFGTDVYDETKENKPKYEHEEGLEFGSDFDFDGEFEKYAAMGAAEKQSGAWMTNFKNLEFPLGVSPSVLVQTLGIFAAFCGILSGVDQSLISGASIGMDKSLHFNSHENSLVSSLMPLGAVAGSILLTPLQRFGRKKALMASCILYTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLI4</accession>
    <name>C4YLI4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_01702</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLI4"/>
    <dbReference type="PaxDb" id="5476-C4YLI4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01702"/>
    <dbReference type="HOGENOM" id="CLU_014689_3_2_1"/>
    <dbReference type="OMA" id="HEQGNFR"/>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030697">
        <property type="term" value="F:tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025795">
        <property type="entry name" value="tRNA_(uracil-5-)_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="RNA M5U METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061:SF30">
        <property type="entry name" value="TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51622">
        <property type="entry name" value="SAM_MT_RNA_M5U_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="539"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="539"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ43465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="588" mass="67523" checksum="F6895CCF67FCCB26" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-01-11" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLS2</accession>
    <name>FEN1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flap endonuclease 1</fullName>
            <shortName evidence="1">FEN-1</shortName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">RAD27</name>
        <name evidence="1" type="synonym">FEN1</name>
        <name type="ORF">CAWG_01791</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with PCNA. Three molecules of RAD27 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="1">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated. Phosphorylation upon DNA damage induces relocalization to the nuclear plasma.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLS2"/>
    <dbReference type="SMR" id="C4YLS2"/>
    <dbReference type="PaxDb" id="5476-C4YLS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01791"/>
    <dbReference type="HOGENOM" id="CLU_032444_2_0_1"/>
    <dbReference type="OMA" id="MGIPWVQ"/>
    <dbReference type="OrthoDB" id="1937206at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000009">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000003">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000403566" description="Flap endonuclease 1">
        <location>
            <begin position="1"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-domain">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="I-domain">
        <location>
            <begin position="123"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with PCNA" evidence="1">
        <location>
            <begin position="339"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="372" mass="42158" checksum="B27A9317A1AFD5F8" modified="2009-07-28" version="1">MGVKGLNQLIKEHSPSAYKEFQLKNLFGRKVAIDASMCLYQFLIAVRQSDGQQLTNEDGETTSHLSGMFYRTIKMVENNIKPVYVFDGKPPVLKGGELEKRLLRREEAQKQKTALGDEGTVEEVLKFEKRLVRVTREQNEEAKKLLQLMGIPCVDAPCEAEAQCAELARGGKVYAAASEDMDTLCYEPPFLLRHLTFSEARKMPIDQIEYKDAIAGLDMTKEQFIDLCILLGCDYCESIKGIGQATAFKLIKEHGSLDNIVEWIKNNKTKYTLPENWPFDEARQLFMNPEVTNASEISLKWKEPDVDGLIEFMVKQKGFSEDRIRSGAEKLKKGLKGGVQGRLDGFFKVVKTDDKKRKADPKESKASKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM06</accession>
    <name>C4YM06_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_01881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM06"/>
    <dbReference type="PaxDb" id="5476-C4YM06"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01881"/>
    <dbReference type="HOGENOM" id="CLU_128307_0_0_1"/>
    <dbReference type="OMA" id="AQMASNY"/>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="158" mass="18894" checksum="EB32B36EE71AF30A" modified="2009-07-28" version="1">MLSDKEVSLDKQLNYWRKQKDTLTKATTYLKEQANIDQLIDKYSAIAQMASNYLYNEYCLKFTKLGGYANWQLQQWKENQSNNVDYELESLYSSYFDSEEFNQLSDLEKREIMLDYEEKFGHDDNNKENIPVFTDVFTMKDLYSILNLDYELVYPPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM62</accession>
    <name>C4YM62_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM62"/>
    <dbReference type="PaxDb" id="5476-C4YM62"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01938"/>
    <dbReference type="HOGENOM" id="CLU_750104_0_0_1"/>
    <dbReference type="OMA" id="IFLPLWF"/>
    <dbReference type="OrthoDB" id="4088947at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="359" mass="41198" checksum="A2F63930C0E30431" modified="2009-07-28" version="1">MITRNILRLSIRNWNCARPVTSFLPCRRFLNTTLPRQLRGRSTINQLIQSNTQSTMFPIQRNNRLPLRTIVILIAASSSLTMLLFVAVQYKKFQDELLPDGKSRKRSIFLPLWFNGNLLYQTTYGFPHGLKYFDPEFYEYIMTEVQQSNKDGEMQGHHDNSVKHFCHALQEKNIKYAVLEGLSANREIRQIFGLPLTVDTHPNSDGELKIWVESKYPSVSGLQIDITKTVDTNGSNNSKFDFHWIVKPINAVSVINSAMTSTGLGLDRLESSEANIKTHEQGSGKVHEVKMDKEKVNLNKQRDYAIQFRGKFMVSDKSMVRVGVVEYCGTIDFDHLMINRGVKITNMDMKHDGVLYKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YML4</accession>
    <name>C4YML4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ca3427-like PBP 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_02097</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein SsuA/TauA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YML4"/>
    <dbReference type="PaxDb" id="5476-C4YML4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02097"/>
    <dbReference type="HOGENOM" id="CLU_061316_1_0_1"/>
    <dbReference type="OMA" id="HFNLPWH"/>
    <dbReference type="OrthoDB" id="1363at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd13637">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054364">
        <property type="entry name" value="Ca3427-like_PBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024">
        <property type="entry name" value="ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024:SF47">
        <property type="entry name" value="TAURINE-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22384">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Periplasmic binding protein-like II"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ca3427-like PBP 2" evidence="4">
        <location>
            <begin position="88"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ43845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="269" mass="30522" checksum="B90424D08F914143" modified="2009-07-28" version="1">MPTLKVAYIPEHFSTPLFFAQQQGYYKAHDLSIEFVKVPEGSGRLINLLNSNEVDIAIGLTEAFIADIAKGNENIHVLDTYVKSPLLWAVSTGSNRDDVTDAKQLKRIGVSRIGSGSYVMSFVLAHQLGVPSFDQFQVLSNFKNLRDSVNLKDGVEGSDAFMWEYFTSKKYYDNHEIKQIDQIYTPWSSWVVATSSDSLQAKSDAIKNFIDAVNQAIQYYNEHVDEAIEYISSNLDYSAEDAKEWTKTVEFNFKDRKDAIGLGHYRRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMN7</accession>
    <name>C4YMN7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMN7"/>
    <dbReference type="PaxDb" id="5476-C4YMN7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02120"/>
    <dbReference type="HOGENOM" id="CLU_005210_0_0_1"/>
    <dbReference type="OMA" id="GWGANTK"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="291" mass="31621" checksum="6C7EF0D11CC34CA1" modified="2009-07-28" version="1">MKIAGGGNHTMVILDNGEVFTCGSNEFGQCGLPRGESLGVFHKVPGNDWLDISCGWEFSILVKRSGEVYVCGRGLKGELGLGKETPESELIYSTTVDGFKEIKSCMQHTIIQTTNGLVGWGNSRKGQLGETEDKIMWTPKTLRFGVVCKDFSLGREFTAIQTDTNRVKIFGKSSIKNIPESTVARVAAMWSSVHILSETNVLQSFGNNSHEQLFPNNSSVAVEEYAIGSEHGLVTSDNIVYAWGWSEHGNCGTSNASDKVTFDYLNKLYTGSAKVVLIGAGCATSWVVVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN07</accession>
    <name>C4YN07_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar RNA-associated protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_02245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN07"/>
    <dbReference type="PaxDb" id="5476-C4YN07"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02245"/>
    <dbReference type="HOGENOM" id="CLU_003783_0_2_1"/>
    <dbReference type="OMA" id="QVIEPMD"/>
    <dbReference type="OrthoDB" id="277439at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006709">
        <property type="entry name" value="SSU_processome_Utp14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150:SF12">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04615">
        <property type="entry name" value="Utp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="64"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="486"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="619"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="752"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="152"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="489"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="643"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="752"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ43988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="872" mass="100619" checksum="57525E3BA7D09310" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN43</accession>
    <name>C4YN43_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_02283</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN43"/>
    <dbReference type="PaxDb" id="5476-C4YN43"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02283"/>
    <dbReference type="HOGENOM" id="CLU_023936_0_0_1"/>
    <dbReference type="OMA" id="WVKWCLI"/>
    <dbReference type="OrthoDB" id="30195at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:003000">
        <property type="entry name" value="Utp5p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:003046">
        <property type="entry name" value="Utp5p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052414">
        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="5">
        <location>
            <begin position="449"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="587"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="592"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ44024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="636" mass="71326" checksum="D166FE49939D0770" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN84</accession>
    <name>C4YN84_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_02324</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN84"/>
    <dbReference type="SMR" id="C4YN84"/>
    <dbReference type="PaxDb" id="5476-C4YN84"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02324"/>
    <dbReference type="HOGENOM" id="CLU_012062_37_0_1"/>
    <dbReference type="OMA" id="EMEQNCN"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000029">
        <property type="entry name" value="peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000045">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="8 11" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="7"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="306"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ44065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="369" mass="40740" checksum="80664D1825F1C7E6" modified="2009-07-28" version="1">MTATPVYFDISCNGKPKGRVVFKLYDDVVPKTAANFRSLCTGDKGISPKSGKPLSYKDSIFHRVIKDFMCQGGDFTAPSDHLGTGGESIYGEKFEDENFKLNHNKPFLLSMANSGPNTNGSQFFITTVPTPHLDGKHVVFGEVIEGKSIVRQLERSEKGANDRPVEDWKIADCGELPANYEPVASGADDGTGDTYEEILTDNDTIDINNPQSVFAAVSKIKDIGTKLLKEGKLEKSYEKYTKANSYLNDYFPEGLSPEDLSTLHGLKLSCYLNAALVALKLKHGKDAIAAANNALEVEQIDDKSKTKALYRKGMGYILVKDEEQAQKILEEALELEPNDAAIQKGLQEAKHNIKLRRDKQKKAMAKFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YND9</accession>
    <name>C4YND9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_01398</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YND9"/>
    <dbReference type="PaxDb" id="5476-C4YND9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01398"/>
    <dbReference type="HOGENOM" id="CLU_515868_0_0_1"/>
    <dbReference type="OMA" id="MAHFEDF"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="6">
        <location>
            <begin position="38"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ43172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="463" mass="53185" checksum="6838C0EFBF50DF51" modified="2009-07-28" version="1">MQVWKNSFDENLMIEQTFTFAMRDFINGSNKRGPASVNAPELLSVYMDYFIKQLTKGSSSNKDISLKSGDQTEDLISNSIQFLRFIKDKDAFEANYANHFAKRFLNSKTGNSPSSNKDIEEIILAKLSEEMGTSSLDKVIKMNRDVRSSKDTTNDWKRYLNKQSKSTDLVEMELKICNVTDWPKSMTKDYKWFSRTENEETPFKWPRQLRNTIKQFDEFWSNGKKNDNKSLYWSPKFGSMDLRITYPSRTYEINLSTFAAIIMLLFAPQSTNADGSTVSAFDEMKELTYEEILELTGIPEPELKRHLQSIAVAPKSRLLVKVPMSKDVNKNDVFKLNAKFKSPSVKVKVLTVSASSSSSASSSSSSSKNTNKSVAKTEQEEELEEVNANIMEGRKIEVNAAIVRILKSRQSIKHNDLIEELLKQLSNRFQPSIILIKQRIEDLIDKEYLKRDTDDRNLYHYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNJ9</accession>
    <name>C4YNJ9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AP-1 accessory protein LAA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YNJ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01461"/>
    <dbReference type="HOGENOM" id="CLU_231988_0_0_1"/>
    <dbReference type="OMA" id="WEFKLFI"/>
    <dbReference type="OrthoDB" id="192608at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046837">
        <property type="entry name" value="Laa1/Sip1/HEATR5-like_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20210">
        <property type="entry name" value="Laa1_Sip1_HTR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2031" mass="232811" checksum="D788C6792F2BEB7A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNN1</accession>
    <name>C4YNN1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SANT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_01494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNN1"/>
    <dbReference type="PaxDb" id="5476-C4YNN1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01494"/>
    <dbReference type="HOGENOM" id="CLU_021041_0_0_1"/>
    <dbReference type="OMA" id="EDQHAKE"/>
    <dbReference type="OrthoDB" id="272624at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017174">
        <property type="entry name" value="Bdp1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037327">
        <property type="entry name" value="TFIIIB_Bdp1_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANT" evidence="2">
        <location>
            <begin position="500"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ43264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="660" mass="73778" checksum="036358F79FBC5E3E" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNP8</accession>
    <name>C4YNP8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_02830</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Lipid-anchor</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the small GTPase superfamily. Rheb family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNP8"/>
    <dbReference type="SMR" id="C4YNP8"/>
    <dbReference type="PaxDb" id="5476-C4YNP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02830"/>
    <dbReference type="HOGENOM" id="CLU_041217_9_8_1"/>
    <dbReference type="OMA" id="SARHNEN"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04137">
        <property type="entry name" value="RheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000273">
        <property type="entry name" value="GTP-binding protein Rheb homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ44557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="21120" checksum="BD01F91525157738" modified="2010-10-05" version="1">MSVKARKIAVVGSRSVGKSSITVRFVEDHFVESYYPTIENQFSKSIKFNNQDYAIEILDTAGQDEFSLMNEKHLIGIHGYLLIYSVTSQQSFETVEFIRDKILNSIGNESIPMVLVGNKNDLTYQRQVETTQGQELAKKFNCKFLETSVRENINVEKAFETLIDEIEKIQNPPIQKQQEKCIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP78</accession>
    <name>C4YP78_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_03023</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YP78"/>
    <dbReference type="SMR" id="C4YP78"/>
    <dbReference type="PaxDb" id="5476-C4YP78"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03023"/>
    <dbReference type="HOGENOM" id="CLU_110343_1_0_1"/>
    <dbReference type="OMA" id="CAEHQIP"/>
    <dbReference type="OrthoDB" id="10249311at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000019">
        <property type="entry name" value="40S ribosomal protein S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047860">
        <property type="entry name" value="Ribosomal_eS12_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00972">
        <property type="entry name" value="RIBSOMALS12E"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01189">
        <property type="entry name" value="RIBOSOMAL_S12E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="27"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ44737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="143" mass="15698" checksum="D45AB11AE511904E" modified="2010-10-05" version="1">MSDVEQEQIVEEVVVEEQSGAITIEDALKVVLRTSLVHDGLARGLREASKALSKREAQLCVLCDSVTEESIIKLVEALCNEPEEKIPLIKVSDAKLLGEWAGLCQLDRDGNARKVVGASCVVVKNWGADSDERNILLEHFSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP99</accession>
    <name>C4YP99_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="5">30S ribosomal protein S10, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_03048</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YP99"/>
    <dbReference type="SMR" id="C4YP99"/>
    <dbReference type="PaxDb" id="5476-C4YP99"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03048"/>
    <dbReference type="HOGENOM" id="CLU_051208_4_0_1"/>
    <dbReference type="OMA" id="LRKHQFY"/>
    <dbReference type="OrthoDB" id="366214at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="4">
        <location>
            <begin position="88"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ44758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="234" mass="27401" checksum="8A93F8C8F996A94A" modified="2009-07-28" version="1">MLRIGYRGFSTRSRVFKLSPQEYVNQVQQEKIENEQFKQALSQDQLEYNPKILSSHKLTKNRPIPINVELLKYKPLRLPKTHGDEVATLTIRGYDEDNLIRVGEFALRTAYYMGIPMSPLMALKTEKRLYTVIKSPFAQAKTKQNFHRVTYKKKLVAYDANPEIIDLWLSYINKNKFTDVEYKATVSSYESLNYHEELKSLKEFNLPDAYEGIEDPVAKKVQELLKSKSFKKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPD9</accession>
    <name>C4YPD9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_03092</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPD9"/>
    <dbReference type="PaxDb" id="5476-C4YPD9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03092"/>
    <dbReference type="HOGENOM" id="CLU_921321_0_0_1"/>
    <dbReference type="OrthoDB" id="4159781at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ44799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="302" mass="35496" checksum="4523E387F926F464" modified="2009-07-28" version="1">MEQSIVKHIWRSTDLFVSLRKLVEIISKTSEDTPLETVLELLAEVETKLQAFLATIDLEGTNVFYNDLVIFPVNFLLVYMYYSLYLFKGPTPLGNKYLLKSAQILFVDLARTRSTSLFLAYFNLNYIHLVLMITNFLRMRVDCIIHRHLRAQDSSVQDLQCCRYFLKIIFFSHVKELGNYSSSHKYAWQMRKVYLTLAKIMERSSDVLISNDPELVKSAAVDIPVKEINKLLEQYINFKGFTPTTLFDPTDNELIDEMQHENLWNAMENIEYSEKVYSGWIDAIKNVPSNWDWDYWDFLKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPH4</accession>
    <name>C4YPH4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_02374</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPH4"/>
    <dbReference type="SMR" id="C4YPH4"/>
    <dbReference type="PaxDb" id="5476-C4YPH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02374"/>
    <dbReference type="HOGENOM" id="CLU_028824_3_1_1"/>
    <dbReference type="OMA" id="DDFPSIC"/>
    <dbReference type="OrthoDB" id="19859at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ44113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="270" mass="29338" checksum="5B5DE2ECB1120C87" modified="2010-10-05" version="1">MTLVLIALPLVMFVATFVAGILPLKLTVAQHHLKYLSFLSMGILIGTAMMIILPEGIETISHETTDVASYVGFPILLGFLTMYILDCMFSTNVKAQESSVVESVVGSPITLGLIFHGIIDGISLGSSLASGEVMTLIIFAAIIIHKIPTSFSLSTILLQEGTSDSKLYWHILLFALSSPSACWFTFVLIKLVNAKSNLVIGVLFLYSAGTFLFVVNHVMHEFSSNDFYTLPTSVESDTTTVESHSKISRNELILSLIGILIPTLLSFAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPN1</accession>
    <name>C4YPN1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_02432</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPN1"/>
    <dbReference type="PaxDb" id="5476-C4YPN1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02432"/>
    <dbReference type="HOGENOM" id="CLU_012062_37_0_1"/>
    <dbReference type="OMA" id="QFFITTY"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00317">
        <property type="entry name" value="cyclophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000029">
        <property type="entry name" value="peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000102">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="11"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ44170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="374" mass="42606" checksum="F48817289D601223" modified="2009-07-28" version="1">MQIEKVQPKAYFDITNGSKKLGRVVFELYDDLAPKATENFLNLCKGITLNDKSYSYQDTIFDKVIKNFMIQGGSLNANVSTIYGDQGINKPILGENLSDDLSHPFKLCMANNGDVNCNGSQFFIITSKQSHMAGKYSIFGHVIHGKSIIREIERVKTNKDDVPESNVVIDQCGVWTDDMPVPIFNASYDTIGGDIYEEYPEDDNSNFNQESTEEAFSVASKIKESGTLLYKKGDKENARFKYIKALRYIMEFIPDPDQDPEWYKKFIDLKKKTYLNLSLCCLQLKDYHRCIDYCSYLLDMDDSVLTKQDKTKTLFRKGSANVGLKKYKLGLDDLKSANILTPDDVSIQKSIESTEKLLQQQKQNEKATYSKFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQC6</accession>
    <name>C4YQC6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Increased rDNA silencing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_02683</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the IRS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQC6"/>
    <dbReference type="SMR" id="C4YQC6"/>
    <dbReference type="PaxDb" id="5476-C4YQC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02683"/>
    <dbReference type="HOGENOM" id="CLU_020874_0_0_1"/>
    <dbReference type="OMA" id="WDLVDFR"/>
    <dbReference type="OrthoDB" id="10045710at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000326">
        <property type="entry name" value="IRS4p EH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="4">
        <location>
            <begin position="566"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="572"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="15"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="270"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="409"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00061579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ44415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="638" mass="71771" checksum="C772E05653727C55" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQE7</accession>
    <name>C4YQE7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">candidapepsin</fullName>
            <ecNumber evidence="4">3.4.23.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_02704</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 of insulin B chain. Activates trypsinogen, and degrades keratin.</text>
            <dbReference type="EC" id="3.4.23.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.24" evidence="4"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQE7"/>
    <dbReference type="MEROPS" id="A01.067"/>
    <dbReference type="PaxDb" id="5476-C4YQE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02704"/>
    <dbReference type="HOGENOM" id="CLU_013253_9_1_1"/>
    <dbReference type="OMA" id="IWGYDDV"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000023">
        <property type="entry name" value="Aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944872" description="candidapepsin" evidence="16">
        <location>
            <begin position="18"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="17">
        <location>
            <begin position="65"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="406"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ44436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="544" mass="58539" checksum="34F9F487F2EC497B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQN5</accession>
    <name>C4YQN5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hyaluronan/mRNA-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_02794</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQN5"/>
    <dbReference type="SMR" id="C4YQN5"/>
    <dbReference type="PaxDb" id="5476-C4YQN5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02794"/>
    <dbReference type="HOGENOM" id="CLU_043312_2_0_1"/>
    <dbReference type="OMA" id="KKWAGAK"/>
    <dbReference type="OrthoDB" id="5426471at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039764">
        <property type="entry name" value="HABP4/SERBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006861">
        <property type="entry name" value="HABP4_PAIRBP1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019084">
        <property type="entry name" value="STM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299:SF17">
        <property type="entry name" value="AT19571P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299">
        <property type="entry name" value="HYALURONIC ACID-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09598">
        <property type="entry name" value="Stm1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01233">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan/mRNA-binding protein" evidence="4">
        <location>
            <begin position="84"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="216"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ44524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="267" mass="29072" checksum="4A11447A892771E2" modified="2009-07-28" version="1">MSFQNKNLYDLLGNDVEEDAAPSAPSREVVKKNTSSKKSDAAPASADPAKAKKKKSPTGNEAALKNKNFNKDVAPPQSTATKHSKKPFDRHSRTGKTDSKKKLQQGWGQSDKRELEGEVEGTEDAEAELEAEAEENDESANAIPKKSLQEYLAELELSKQELEGSKKLRQANEGAEQKWTAEEKIEKQQEVFFASTHTKKAKSKAQKEKVFLDIDANFGDEQPQTTRGGFRGGKRGGARGGSRGGAKRGGARGAAKPEVNDKNFPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQP5</accession>
    <name>C4YQP5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_02804</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQP5"/>
    <dbReference type="SMR" id="C4YQP5"/>
    <dbReference type="PaxDb" id="5476-C4YQP5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02804"/>
    <dbReference type="HOGENOM" id="CLU_000134_18_2_1"/>
    <dbReference type="OMA" id="WAVAYNR"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF11">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ44534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="248" mass="27178" checksum="3F83E62FFF1E09FC" modified="2009-07-28" version="1">MSNASQSNKFAIHDAIKEGNTLLAKKLIDEQPASKLYISDDDERTPLHWAVSFNNPDLVQYILSKTPNDLDIDEYVDGSGWTPLHIAAALGNSTIFNQLMRRANGTTTTSNNSTQPELDVNLQTNSGTTCLHLAISKNNYDIVKELIETYKANCRIKDKKGYTPLHRAASIGSTPIIKLLVEKGKININAQDNDGWTSLHHALAEGHGDVAVLLVKLGADPNIVNNDGETPVKIAVDDKVAKYFTENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQQ8</accession>
    <name>C4YQQ8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_04405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQQ8"/>
    <dbReference type="SMR" id="C4YQQ8"/>
    <dbReference type="PaxDb" id="5476-C4YQQ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04405"/>
    <dbReference type="HOGENOM" id="CLU_087023_0_0_1"/>
    <dbReference type="OMA" id="WDSMDYR"/>
    <dbReference type="OrthoDB" id="4010386at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012470">
        <property type="entry name" value="Pup1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07954">
        <property type="entry name" value="DUF1689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="220" mass="25759" checksum="300BEC17BDBC2D96" modified="2010-10-05" version="1">MKKKNFAPLSFLWLIMSDNILRDRLGPEKFEKAVEFYDADQKLTPEDRVQIRDDLKSVLVGDNLASYGSGLIGFLMPTIYMRFFKKGSVNAKSFFQKPLLSGAIGVANMMVTHRIYSKKLFDEKVSSGLPERQLNVWKAMEQRSLGVYMFYYAKTAQDPKFKLEDPREYTEENRLKVRFDPEKYKEGHPHDELSTWDRIRLSNGYDITEEKSAWDEIRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQU7</accession>
    <name>C4YQU7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="17">ATP-dependent helicase NAM7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_04444</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs. Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQU7"/>
    <dbReference type="PaxDb" id="5476-C4YQU7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04444"/>
    <dbReference type="HOGENOM" id="CLU_001666_4_1_1"/>
    <dbReference type="OMA" id="QYMQMNG"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21407">
        <property type="entry name" value="1B_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18039">
        <property type="entry name" value="DEXXQc_UPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21400">
        <property type="entry name" value="ZBD_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000097">
        <property type="entry name" value="Regulator of nonsense transcripts 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040812">
        <property type="entry name" value="UPF1_1B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018999">
        <property type="entry name" value="UPF1_CH/ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF364">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18141">
        <property type="entry name" value="UPF1_1B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09416">
        <property type="entry name" value="UPF1_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51997">
        <property type="entry name" value="UPF1_CH_RICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Upf1" evidence="16">
        <location>
            <begin position="85"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="C3H" evidence="15">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="CC/SHH/C" evidence="15">
        <location>
            <begin position="107"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="C4" evidence="15">
        <location>
            <begin position="153"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ46100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1019" mass="114639" checksum="762D95EED9BDEA20" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR32</accession>
    <name>C4YR32_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_04531</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR32"/>
    <dbReference type="PaxDb" id="5476-C4YR32"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04531"/>
    <dbReference type="HOGENOM" id="CLU_715709_0_0_1"/>
    <dbReference type="OMA" id="DLFFCDE"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF23">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="109"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ46185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="405" mass="47798" checksum="0D3D657990FB9BAE" modified="2009-07-28" version="1">MIWSKEYLKKNYIKLLVPICVVLVLAYLNYAINYAVGYKLVYVHHSHAVAIILWVLLGFFQLELLVYWVLIFLVGPGKSPVFPPIDLYSENNKGLIPLPDLFFCDEKGFPYYCSNSNSIKLERSFFSKDVGYNVIKFDHYCIWIGQPIGQDNYLFFMKFMMGFLAFFIIVLIYCARFTRESIQQGEIDHNFIVLFVMSGFWIIMIGCLFGIHLRYVSINMTTLDEITINQRKRYNRWKDARKNPNMPSWMKPKHPPRKETGRRYVNVKHKTGRAIVRYYIDERPFDMGFRRNWINLVFNGNRNHGKDDEFYTLWRLAAAFVVFIIPFIDIPFSFRGKLQVKDDVEQELHEQENLLAKYTVYSSVVNDKFMNMIDEKLKKNSYSAPGYLVETTPQNNQSTIDKDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR84</accession>
    <name>C4YR84_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_04583</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR84"/>
    <dbReference type="PaxDb" id="5476-C4YR84"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04583"/>
    <dbReference type="HOGENOM" id="CLU_096561_1_0_1"/>
    <dbReference type="OMA" id="ADWMTKH"/>
    <dbReference type="OrthoDB" id="289247at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000309">
        <property type="entry name" value="Chromosome 21, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040250">
        <property type="entry name" value="Nucleobindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237">
        <property type="entry name" value="NUCLEOBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237:SF20">
        <property type="entry name" value="NUCLEOBINDIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946841" description="EF-hand domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ46237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="26337" checksum="B09D6AE95311A689" modified="2010-10-05" version="1">MKLSSVTPLLLTLLSFTTAHGGHGHEQESLKIKPQDLSWQDWHMKEEHGLEEYDGKTFFILHDLNNNGILESKEILNLYGLVHKIIIGDGSGMGQDKIEVTPELQKQVVENIFQLIPHGNPEGISQAEWLKFYENGGRLPDLGYGPGHHLGFEEEYEEHHWRKYHANDDPDVKIKHKEDIEHELLHHQQEIEETHDRSSRLKKFAGDYWSEINIDNLKPKYRKQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRJ3</accession>
    <name>C4YRJ3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_04693</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRJ3"/>
    <dbReference type="PaxDb" id="5476-C4YRJ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04693"/>
    <dbReference type="HOGENOM" id="CLU_030193_0_1_1"/>
    <dbReference type="OrthoDB" id="549017at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ46346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="302" mass="34671" checksum="98748F2A12D84FF4" modified="2009-07-28" version="1">MESIIQIVQYENIARSMISLAIASYLSFSPIYLLPSIIFSIGHVIIRDKAISLPIRQQEKKEGEEDKEQTNVKDLIVKLYVKGLAIFIICVILLIMISFIITASWQFLDNVYLTIILFKNPIPNIGLWWYIFIEMFENYTSFYLIVFNVYTWIFILPFTIRFFQYKNNKITSLLGDSFLAVILCLCWISFIKPYPILGDLGIVLSLLPILNDTIVQYCKLKYITGMTLIIGLLLAPIFYYIWIVLGTGNANFFYSITLIWGAIHGLILMDLIWTKLTLDYYNDNGIDINGEGGSLGLSLAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRR0</accession>
    <name>C4YRR0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_04764</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRR0"/>
    <dbReference type="PaxDb" id="5476-C4YRR0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04764"/>
    <dbReference type="HOGENOM" id="CLU_081098_0_1_1"/>
    <dbReference type="OMA" id="GMMDCLL"/>
    <dbReference type="OrthoDB" id="76105at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000004">
        <property type="entry name" value="rRNA-processing protein FCF1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="7">
        <location>
            <begin position="73"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ46413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="199" mass="22433" checksum="EFE9B1BEF37BAF5E" modified="2009-07-28" version="1">MGKAKKTRKFAAVKRTLNTKKDQRLTQNNANNNNTNKKKGGGGVVDDPELTRSVPQVSSALFFKYNESIKPPYQVLIDTNFINFSIQKKIDIIRGLMDCLMAKCIPIITDCVIAELEKLGSKYRIALKLAKDPRIQRLKCSHVGTYADDCLVNRVIQHKCYIVATNDADLKRRIRKIPGIPIMSVGGHSYVIERLPDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRT2</accession>
    <name>C4YRT2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">COMPASS (Complex proteins associated with Set1p) component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_04789</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRT2"/>
    <dbReference type="PaxDb" id="5476-C4YRT2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04789"/>
    <dbReference type="HOGENOM" id="CLU_115916_1_1_1"/>
    <dbReference type="OMA" id="QLPMHEI"/>
    <dbReference type="OrthoDB" id="417678at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22965">
        <property type="entry name" value="DD_DPY30_SDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007858">
        <property type="entry name" value="Dpy-30_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049629">
        <property type="entry name" value="DPY30_SDC1_DD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05186">
        <property type="entry name" value="Dpy-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ46435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14375" checksum="3FCD96588EA710C9" modified="2009-07-28" version="1">METPIPNQDTAKENLETHVNESIDNSDQTENKPTNGSVDEKPQSSNPMEIDTKEESTKSQINTPVPNENSQLPMHEIVGGSSVRRYLNQHLTKTLLEGLKEVAQIKPEDPLKYLGEYLISKSNESKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS02</accession>
    <name>C4YS02_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl hydrolase family 13 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_04860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS02"/>
    <dbReference type="SMR" id="C4YS02"/>
    <dbReference type="PaxDb" id="5476-C4YS02"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04860"/>
    <dbReference type="HOGENOM" id="CLU_006462_1_2_1"/>
    <dbReference type="OMA" id="MNNHDVP"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000064">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000004">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000087">
        <property type="entry name" value="Oligo-1,6-glucosidase IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000007">
        <property type="entry name" value="Sucrose isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="5">
        <location>
            <begin position="15"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ46505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="582" mass="67943" checksum="C3E5BB3354B3D960" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS53</accession>
    <name>C4YS53_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Est1p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS53"/>
    <dbReference type="PaxDb" id="5476-C4YS53"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04912"/>
    <dbReference type="HOGENOM" id="CLU_015710_0_0_1"/>
    <dbReference type="OMA" id="HYPIFKW"/>
    <dbReference type="OrthoDB" id="69928at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019458">
        <property type="entry name" value="Est1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF0">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10374">
        <property type="entry name" value="EST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomerase activating protein Est1-like N-terminal" evidence="2">
        <location>
            <begin position="94"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA-binding" evidence="1">
        <location>
            <begin position="260"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="612" mass="71828" checksum="467F23D795017BDC" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS72</accession>
    <name>C4YS72_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_04931</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YS72"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04931"/>
    <dbReference type="HOGENOM" id="CLU_002317_2_0_1"/>
    <dbReference type="OMA" id="EQPDYQW"/>
    <dbReference type="OrthoDB" id="308861at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09839">
        <property type="entry name" value="M1_like_TAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000011">
        <property type="entry name" value="Transcription initiation factor TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057345">
        <property type="entry name" value="Ig-like_TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057991">
        <property type="entry name" value="TPR_TAF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25316">
        <property type="entry name" value="TAF2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25577">
        <property type="entry name" value="TPR_TAF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 Ig-like" evidence="10">
        <location>
            <begin position="645"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 TPR repeats" evidence="11">
        <location>
            <begin position="812"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="298"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1359"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1360"/>
            <end position="1371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ46575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1423" mass="161594" checksum="F7A416E5B828666C" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSH7</accession>
    <name>C4YSH7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADPH-dependent 1-acyldihydroxyacetone phosphate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_05043</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSH7"/>
    <dbReference type="SMR" id="C4YSH7"/>
    <dbReference type="PaxDb" id="5476-C4YSH7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05043"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="OMA" id="IWFLNAV"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000261">
        <property type="entry name" value="NADPH-dependent 1-acyldihydroxyacetone phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ46680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="32804" checksum="4C7DE16E89441D34" modified="2009-07-28" version="1">MSPKYALVTGASSGIGYNLAIELSKKGYKVIGCSPQSVLFGQKPLEQEYGVISLPLDVTDIDNIKTVLKKVEEITGGRLDVLYNNAGISISGPAIEIDETQLNKVFQVNVIGQINMTKYFAPLIINAKGTILFTSSVAARVPLSWVSAYNATKAAIDAYALTLHGEMAPFGVRVHSVITGGVDTAICDGNIKTSLGDSFYDVDGVYESIRSSAMMSRDLNISPEQYAKEVVRDIVSWRDPGFNLYHGARSYFLHWVSRFLPLWLVEFGVQIHFKQRRVLQTIAKLIKVKKSQEKKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSK2</accession>
    <name>C4YSK2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_05070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSK2"/>
    <dbReference type="PaxDb" id="5476-C4YSK2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05070"/>
    <dbReference type="HOGENOM" id="CLU_014489_1_0_1"/>
    <dbReference type="OMA" id="YWFVSFE"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000101">
        <property type="entry name" value="Transcription factor with zinc cluster DNA-binding motif, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ46705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="592" mass="67303" checksum="E519B99068007255" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSN2</accession>
    <name>C4YSN2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_05100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the USE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSN2"/>
    <dbReference type="PaxDb" id="5476-C4YSN2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05100"/>
    <dbReference type="HOGENOM" id="CLU_093900_0_0_1"/>
    <dbReference type="OMA" id="YHESIQD"/>
    <dbReference type="OrthoDB" id="4008582at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019150">
        <property type="entry name" value="Vesicle_transport_protein_Use1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050">
        <property type="entry name" value="USE1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050:SF7">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09753">
        <property type="entry name" value="Use1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ46735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="280" mass="32078" checksum="9511F85C5B96B81A" modified="2010-10-05" version="1">MSLTSIHTIESILSQINKDVQELDIPSIYQLSTTTTTANTIPKTSPYITRFKLLQIKNSLTNLNDQFHANFTSSNNKHYHNVKQTLDKLYINEIDEKLYIVDKLITQYDDANSPTTLNGDDQQQQNQQGEQNLQRGNSGVITNDEELSSLRQRLLSSSKLHQINQDNTSESDSTKLNEYHESIQDDIVNELSELTSTLKSKAIEFSNKLLNQDSDILQQTHDNLSINRTMFDTLNKNLNDYLLNKTGWSISIWTLLKFAVALIVIFVVMLLFIIIVPRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C4YST0</accession>
    <name>C4YST0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein sorting-associated protein 68</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_05149</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YST0"/>
    <dbReference type="PaxDb" id="5476-C4YST0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05149"/>
    <dbReference type="HOGENOM" id="CLU_096876_0_0_1"/>
    <dbReference type="OMA" id="VHITFVD"/>
    <dbReference type="OrthoDB" id="268928at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ46783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="19828" checksum="6DE1BB6C076E5F2B" modified="2010-10-05" version="1">MDHNHSSNLFRFASIQLPKSAKLRSFGIYLSGALFAIGFWSLVDASIYSKTINASDVHVNFIDWIPFLASSMGMLIVNSIEKSNLMINPNNQNDFTGSGGNGGGHAWAARIILFMGFSLLAGGLAGSFMVFILKYLMNHYTFPTLGMGVANIVCNGCVMLSCIFLWLSQNIEDEYSYSLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT75</accession>
    <name>C4YT75_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_05361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT75"/>
    <dbReference type="PaxDb" id="5476-C4YT75"/>
    <dbReference type="HOGENOM" id="CLU_3379575_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="35" mass="3920" checksum="3F262973C7021605" modified="2009-07-28" version="1" fragment="single">MDIVLEIDKYCVRVGVVGEVTPVVVPVKYEWVGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTF4</accession>
    <name>C4YTF4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_05444</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTF4"/>
    <dbReference type="PaxDb" id="5476-C4YTF4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05444"/>
    <dbReference type="HOGENOM" id="CLU_012358_0_0_1"/>
    <dbReference type="OMA" id="CVHMNDS"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046098">
        <property type="term" value="P:guanine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="6">
        <location>
            <begin position="109"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="412"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="594"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="412"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="594"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ46895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="626" mass="72095" checksum="91470F28EA340552" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTN6</accession>
    <name>C4YTN6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="14">ATP-PFK</shortName>
            <shortName evidence="14">Phosphofructokinase</shortName>
            <ecNumber evidence="14">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_05531</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14 15">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14 15">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="14"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTN6"/>
    <dbReference type="SMR" id="C4YTN6"/>
    <dbReference type="PaxDb" id="5476-C4YTN6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05531"/>
    <dbReference type="HOGENOM" id="CLU_011053_0_0_1"/>
    <dbReference type="OMA" id="EWQDQMC"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055082">
        <property type="term" value="P:intracellular chemical homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000063">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000007">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000008">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03184">
        <property type="entry name" value="Phosphofructokinase_I_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 14 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="16">
        <location>
            <begin position="184"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="16">
        <location>
            <begin position="574"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal catalytic PFK domain 1" evidence="14">
        <location>
            <begin position="1"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interdomain linker" evidence="14">
        <location>
            <begin position="560"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal regulatory PFK domain 2" evidence="14">
        <location>
            <begin position="574"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="256"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="286"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="332"/>
            <end position="334"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="376"/>
            <end position="378"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="467"/>
            <end position="470"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="644"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="702"/>
            <end position="706"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="747"/>
            <end position="749"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="833"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="839"/>
            <end position="842"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="920"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ46977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="946" mass="104132" checksum="4DC8684F278181DA" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTW3</accession>
    <name>C4YTW3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTW3"/>
    <dbReference type="PaxDb" id="5476-C4YTW3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05609"/>
    <dbReference type="HOGENOM" id="CLU_624948_0_0_1"/>
    <dbReference type="OMA" id="TIQTTGH"/>
    <dbReference type="OrthoDB" id="4022940at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="512" mass="56888" checksum="BE2A66CFA6C28117" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C5K449</accession>
    <name>C5K449_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_06152</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG670279">
        <property type="protein sequence ID" value="EEQ43131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C5K449"/>
    <dbReference type="SMR" id="C5K449"/>
    <dbReference type="PaxDb" id="5476-C5K449"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06152"/>
    <dbReference type="HOGENOM" id="CLU_053359_3_0_1"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Unplaced Supercontig 1.11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF2">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="8">
        <location>
            <begin position="116"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ43131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="245" mass="27095" checksum="D37007AAEA676F56" modified="2009-07-28" version="1">MSTSSKRQSNQSLSSSYGSIQAESASPRPIFRTGSKTNTSNILSATTTTQNNDTSGPHSPSSLTSGHPLLNNNSDNDNDEIEDITDIKPEDELNDYHLDLLNYKSITLENKGSVARDHMANERTFLAWLRTSLAFITLGIGITQLFRLEKPNSKIQTSSAVIPLSRTPHNGENSQIITRFGKPLGSVFIVLGMLTLLFGMKRYFQVQYFLTKDYYPATRLSIFVLISIILAIVVVTFGLVLKTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCL5</accession>
    <name>C4YCL5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Vta1p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_00249</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCL5"/>
    <dbReference type="PaxDb" id="5476-C4YCL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00249"/>
    <dbReference type="HOGENOM" id="CLU_679712_0_0_1"/>
    <dbReference type="OMA" id="YCKIYVL"/>
    <dbReference type="OrthoDB" id="391137at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="10">
        <location>
            <begin position="17"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="11">
        <location>
            <begin position="360"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="199"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ42051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="46208" checksum="C6C12EAAFDAA5D7E" modified="2009-07-28" version="1">MTITTASVPEELKTDKSVTPFIIRSIELSQANPIVSYYCKIYVLEHILTNKLHTTSKEIELFTIELLDDTESIKNNTEDEDFHKILNNKQLSLNVVLSFTYKLFNSCLETLSNLTSSKQQQSALISKMKATLNFLSLMAVFKSSEDIDWEKISGGKANDWDSFDKLNKEKIKILKYQLSRLLKGEIQVKDELNHEELEKELDTELEEISGEDVEPEHHEQSGIEKETTEEINLPGAPNDMPKFIEEKDEHSPQLPRAPSTLNESNKGEEEDNDNDDSVKLPGVPHFPPDEEDDTVKLPGAPKYLPDDDLSHINKSSTIQVFPPTDGTQKKSDSPIKKPSATKHHPPLTKEGIKQILNRDDTITQVQKHAKFAQSALQFEDFSEAEKQLTQGLELLKILRKQEEEEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCN4</accession>
    <name>C4YCN4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_00268</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCN4"/>
    <dbReference type="PaxDb" id="5476-C4YCN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00268"/>
    <dbReference type="HOGENOM" id="CLU_652107_0_0_1"/>
    <dbReference type="OMA" id="QHHDELD"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="248"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="101"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="180"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="411"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="446"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ42070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="470" mass="52362" checksum="7CDC1C43095CD949" modified="2009-07-28" version="1">MYSPTFSTRTESSSRTTSSTTKTPPLEMGLNKLNNNRNNGSNNNVSDATNMEHSYSMPVTDIHGLMTDKDDISLDIFKMYNKKYLPQEHQQQHQRISNLAWRISSNKSKVNKPTRRSSSQSSASSIPLPTSGLASSAPPNKSTVRNNSITKSLNQTLLNDSSLDEFDYVAHIRKISQEEYSQQSSKLSPNNNNNNNNNNNNKNNTNFLSSYISSLESTLKQQKSQQQSQPPSQPQPQSSAPVSQSGQPKKVLQCTNCQTRTTPLWRKANNGDLLCNACGLFYKLHGVLRPINGDKKRKYTKRNDKMISTDNTNIFAGLSQQNHGSSQDIAKSQPSLHSFVSQNEQPWGFDNGAIPVFNSFDALVGSNINANNTSNNTTNANNNNNTDNNVDEIDKLLNMNIFQTDFSLNNNNNHHQHHDELDLLDPNGLPPGGGHFNNDPDRQNHTTNNDSNDNSTTNNSWNWLDFSPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCQ5</accession>
    <name>C4YCQ5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Inorganic phosphate transporter PHO84</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_00289</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCQ5"/>
    <dbReference type="PaxDb" id="5476-C4YCQ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00289"/>
    <dbReference type="HOGENOM" id="CLU_001265_46_14_1"/>
    <dbReference type="OMA" id="DKMWRVV"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17364">
        <property type="entry name" value="MFS_PhT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000421">
        <property type="entry name" value="Inorganic phosphate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004738">
        <property type="entry name" value="Phos_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00887">
        <property type="entry name" value="2A0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="57"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ42091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="554" mass="60239" checksum="4B3E9F884B41F088" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCR6</accession>
    <name>C4YCR6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribosomal protein L37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_00300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCR6"/>
    <dbReference type="PaxDb" id="5476-C4YCR6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00300"/>
    <dbReference type="HOGENOM" id="CLU_150908_0_0_1"/>
    <dbReference type="OMA" id="RMAYLKH"/>
    <dbReference type="OrthoDB" id="10259236at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000001">
        <property type="entry name" value="Ribosomal protein L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00547">
        <property type="entry name" value="Ribosomal_eL37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_eL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018267">
        <property type="entry name" value="Ribosomal_eL37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01077">
        <property type="entry name" value="RIBOSOMAL_L37E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ42102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="89" mass="10020" checksum="EDDCEE99F7CD4F34" modified="2009-07-28" version="1">MEGTPSLGKRHNKSHTLCNRCGRRSFHVQKKTCSSCGYPAAKMRSHNWALKAKRRRTTGTGRMAYLKHVTRRFKNGFQTGVAKAQTPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCU5</accession>
    <name>C4YCU5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Regulator of rDNA transcription protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_00329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCU5"/>
    <dbReference type="PaxDb" id="5476-C4YCU5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00329"/>
    <dbReference type="HOGENOM" id="CLU_042558_0_0_1"/>
    <dbReference type="OMA" id="IWIFRTR"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ42131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="31656" checksum="1DC2DB43A59EF75D" modified="2010-10-05" version="1">MDIILILLQRVNVLIPSYTIHFSRSGRHRPLGIAYAEFKTPEQIESVIKEFDGHVLKNRKIAVKKHMAYDPNNRRFSFKRKSSIKNGKRNQTGTLSSEMPVLVAKESLLHDDETVSIKQPKKTHSGKKELSMDTIMIQRVYGKVTDESLRDFFKEYNPSQIYIFKSRKPKLNPMNFTGSHVSVLAKLDASKIKLEDIIFNLKSRKLNGKHINMKPAYKSKVLEVEKAIAQSKSLENTEGCGDTSCNDSVVANEKTSIANKDGKNNDGENSAISLIGTVSNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD24</accession>
    <name>C4YD24_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein kinase CLA4</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_00412</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD24"/>
    <dbReference type="PaxDb" id="5476-C4YD24"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00412"/>
    <dbReference type="HOGENOM" id="CLU_000288_26_2_1"/>
    <dbReference type="OMA" id="NFTHRVH"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13279">
        <property type="entry name" value="PH_Cla4_Ste20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000139">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000761">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="73"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="15">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="686"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="298"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="560"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="371"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="455"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="560"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="623"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEQ42210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="977" mass="107379" checksum="A1AFD422AED879AC" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDF9</accession>
    <name>C4YDF9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_00553</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDF9"/>
    <dbReference type="SMR" id="C4YDF9"/>
    <dbReference type="PaxDb" id="5476-C4YDF9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00553"/>
    <dbReference type="HOGENOM" id="CLU_060138_1_0_1"/>
    <dbReference type="OMA" id="YFWRTLA"/>
    <dbReference type="OrthoDB" id="18786at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019465">
        <property type="entry name" value="Cog5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048485">
        <property type="entry name" value="COG5_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049176">
        <property type="entry name" value="COG5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228:SF3">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20649">
        <property type="entry name" value="COG5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10392">
        <property type="entry name" value="COG5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 N-terminal" evidence="5">
        <location>
            <begin position="17"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ42345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="391" mass="45065" checksum="42D2AA46C8CFDE35" modified="2010-10-05" version="1">MTSQTTEYPTNELEDFEAFLETNFDPQQFANELLLATNGQENPHLDLVTPIKKLKFDIQECDKRIEKISSSNYSSLISNFQKIAEYQKILTTQINPNLERINAPFKRIKQEVVEPFDEAMKLNKALKRIHLTLELLRGTSFFIFIIQQIEELTSVSNERDLVRLAKLHIQINQMYQDATSEKGAEVSVLSVKLIRDYQSIAISKRSNFLSQCINVVSGDFNHPSTLERKNQKLHSHLSALYILDSSEFFNVFDRSTITRKVQSASAQLSRALQSPRNFTAILTEVKEESSEYFTKLSDILSDWKSENDDDKLTFLEIVLKYYKSESLTELFWTKLNQKFKKSIVAAMARGGPIAKNLKIYSQGLKTSVSETFKSEEERNMLLDSLSMIDYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YE47</accession>
    <name>C4YE47_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chloroplast 30S ribosomal protein S12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_00800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YE47"/>
    <dbReference type="SMR" id="C4YE47"/>
    <dbReference type="PaxDb" id="5476-C4YE47"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00800"/>
    <dbReference type="HOGENOM" id="CLU_104295_3_0_1"/>
    <dbReference type="OMA" id="HYDPIKP"/>
    <dbReference type="OrthoDB" id="361013at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000099">
        <property type="entry name" value="Ribosomal protein S12, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ42583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="180" mass="20141" checksum="97F2E7B2CDB46278" modified="2010-10-05" version="1">MIRSLFNGIRLVKPNNTNINGITRPITSYMNSINSNIPILKNHNNNLSSFNQVRHSSLNQIQKYKHYDPIKPNVTKSPDLDNNPFKKGVVLRIMILKPKKPNSALRKCARVRLTNGNVISALIPGEGHNLQEHHVVLVRGGRVQDVPGVKYHLVRGAFDLVGVANRASSRSKYGAKKPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEG1</accession>
    <name>C4YEG1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C-5 sterol desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_00918</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEG1"/>
    <dbReference type="PaxDb" id="5476-C4YEG1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00918"/>
    <dbReference type="HOGENOM" id="CLU_047036_3_0_1"/>
    <dbReference type="OMA" id="GPGLWYN"/>
    <dbReference type="OrthoDB" id="6354873at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="214"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ42697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="386" mass="45447" checksum="E5CF1DBB0A12E83B" modified="2009-07-28" version="1">MDIVLEICDYYLFDKVYADVFPKDGAVHEFLKPAIQSFSQIDFPSLPNLDSFDTNSTLISSNNFNISNVNPATIPSYLFSKIASYQDKSEIYGLAPKFFPATDFINTSFLARSNIFRETLSLFIITTIFGWLLYFIVAYLSYVFVFDKKIFNHPRYLKNQMSLEIKRATTAIPVMVLLTIPFFLLELNGYSFLYLDINECTGGYKAILWQIPKFILFTDCGIYFLHRWLHWPSVYKVLHKPHHKWIVCTPFASHAFHPVDGFFQSLPYHLYPLLFPLHKVLYLFLFTFVNFWTVMIHDGSYWSNDPVVNGTACHTVHHLYFNYNYGQFTTLWDRLGNSYRRPDDSLFVKDVKAEEEKKIWKEQTRKMEEIRGEVEGKVDDREYVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEH9</accession>
    <name>C4YEH9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_00936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEH9"/>
    <dbReference type="PaxDb" id="5476-C4YEH9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00936"/>
    <dbReference type="HOGENOM" id="CLU_1012537_0_0_1"/>
    <dbReference type="OMA" id="FMRNTAP"/>
    <dbReference type="OrthoDB" id="4062597at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ42715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="275" mass="31533" checksum="7C74DEA0E05BA20C" modified="2009-07-28" version="1">MSFEVLALSYSWVHKDSVSSRFENLKHLINASYNKPRYRFGIIQSPRIKNNDTVLSDLAIDAYDEICIYLLLGKQESLDDLANEGYNRDLTKVATTFNQVFANDIPERYYSIFNLDDINTAKITFADSDFEFTDEILNRCIASVGLRSFHGKAKPATKDFELTAFTSFMRNTAPVFLDFIINQCLLDSERFEKISFQGSLNDFQTIIIHADVIKEHGLVEYYTKKCSFTKSSQEDILIKVDNGQKVDDGVLEKGILASKDFHLSFLERIIHIEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEP9</accession>
    <name>C4YEP9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_01007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
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    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL41 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YER6"/>
    <dbReference type="SMR" id="C4YER6"/>
    <dbReference type="PaxDb" id="5476-C4YER6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01024"/>
    <dbReference type="HOGENOM" id="CLU_1778531_0_0_1"/>
    <dbReference type="OMA" id="KHTKYGE"/>
    <dbReference type="OrthoDB" id="408933at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019189">
        <property type="entry name" value="Ribosomal_mL41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09809">
        <property type="entry name" value="MRP-L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ42802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="19308" checksum="D32A5E7FA518DEBB" modified="2010-10-05" version="1">MKVSQVLSFQGSVSSALRRPWQTFRDGTLYYGQLKSGSKRHALTGKQGNKHYYKGTRSTGIGSWDSRGRYHINWEKVRTYVVPEGLNNTELKALVSPKSPKFIQQVVGYRDHFKSPELAFHNAKDFIEYGANYSDVDLEQEGYIHRIVHPDILEAERKENMDVEGIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YES1</accession>
    <name>C4YES1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">General transcription factor TFIIB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_01029</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Associates with TFIID-IIA (DA complex) to form TFIID-IIA-IIB (DAB-complex) which is then recognized by polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YES1"/>
    <dbReference type="PaxDb" id="5476-C4YES1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01029"/>
    <dbReference type="HOGENOM" id="CLU_043736_1_0_1"/>
    <dbReference type="OMA" id="DHDQRMK"/>
    <dbReference type="OrthoDB" id="25790at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20551">
        <property type="entry name" value="CYCLIN_TFIIB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000008">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.170:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000036">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="16">
        <location>
            <begin position="19"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ42807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="344" mass="37968" checksum="76A9A23BE8E0F85F" modified="2009-07-28" version="1">MSPSTSTAVQEYIGPNLNVTLTCPECKIFPPDLVERFSEGDIVCGSCGLVLSDRVVDTRSEWRTFSNDDQNGDDPSRVGDAGNPLLDTEDLSTMISYAPDSTKAGRELSRAQSKSLVDKKDNALAAAYIKISQMCDGYQLPKIVSDGAKEVYKMVYDEKPLRGKSQESIMAASIFIGCRKANVARSFKEIWALTNVPRKEIGKVFKIMDKIIREKNAANPNAAYYGQDSIQTTQTSAEDLIRRFCSHLGVNTQVTNGAEYIARRCKEVGVLAGRSPTTIAATVIYMASLVFGFDLPPSKISDKTGVSDGTIKTSYKYMYEEKEQLIDPFWIESGKVKLEKIPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEV6</accession>
    <name>C4YEV6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_01064</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEV6"/>
    <dbReference type="PaxDb" id="5476-C4YEV6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01064"/>
    <dbReference type="HOGENOM" id="CLU_005663_0_0_1"/>
    <dbReference type="OMA" id="IWAEAST"/>
    <dbReference type="OrthoDB" id="2262349at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
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        <source>
            <dbReference type="EMBL" id="EEQ42842.1"/>
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    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1065" mass="118591" checksum="CC8B115DA1542F26" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF03</accession>
    <name>C4YF03_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_01112</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="EEQ42889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="HOGENOM" id="CLU_025086_2_0_1"/>
    <dbReference type="OMA" id="QIEGWVM"/>
    <dbReference type="OrthoDB" id="238316at2759"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:tRNA binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="17">
        <location>
            <begin position="226"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00015409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ42889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="496" mass="56482" checksum="B55055871CAAD8A1" modified="2009-07-28" version="1">MSDLHLQILKLVDDNNGVIENTLKSPELSKIDVSTLQANLTSLWAKEMIVFSKIETDRWVLTKEAEQYLKAGATPEVQVVDEVLKALEGLTISQLKEKLGPMGAVGQGKAFKNKWLSKDGDKLIAQVEKLPEDVVLNELKTISETGTLNDKKELTELKKRKLVTLTKIVGYKIEKGPKFALEIVNLETDITSDMVLNHTWKDAQFKPYNFNSEGVYPNSGALHPLNKVREEFRQIFFSMGFTEMPSNQYVETGFWNFDTLFVPQQHPARDLQDTFYLKDPKKAGEPEDKQYWENIKQVHQEGKYGSIGYRYPWKAEESLRMVLRTHTTAISAAMLHKLAQDPKPTRLFSIDRVFRNEAVDATHLAEFHQVEGVLAGYDITLGDLIGFMEDFFGKMGVDNLRFKAAYNPYTEPSLEIFAYHKGLKKWVEIGNSGMFRPEMLESMGLPKNLRVLGWGLSLERPTMIKYGVSNIRELLGHKVSLDFIESNPAARLDELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF77</accession>
    <name>C4YF77_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF77"/>
    <dbReference type="PaxDb" id="5476-C4YF77"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01189"/>
    <dbReference type="HOGENOM" id="CLU_051576_0_0_1"/>
    <dbReference type="OMA" id="FHCDEVV"/>
    <dbReference type="OrthoDB" id="10265310at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="334" mass="37858" checksum="F848FA40753BF316" modified="2009-07-28" version="1">MSVSKKIKLDNMVKICTHSGSFHADESLAVYLLKLLPKYSQAELVRSRNPEDWESSDIVVDVSGKYDGVKYFDHHQREFDTTFNENYKTKLSSAGLVYKHFGKEIIKKVLKLEDGNPNIELLYDKIYKEFVESLDANDNGISNYPKDVSPKFTDKNITLPSIVSRLNPSWNESCTDADYDRQFLKSSELMGTVFVSLLEGYGKSWLPAKSIVAKAFDNRFEVDKSGEILVLDQFCPWKEHLYNIEKEKNAEGLIKFVLFKDSSGKWRVSTVSVTSTSFEFRLGLPQELRGLRDQELSEKSGIDGCIFIHAAGFIGGANTKEAVLELSRLSLNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFB4</accession>
    <name>C4YFB4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial outer membrane protein OM14 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_01229</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFB4"/>
    <dbReference type="SMR" id="C4YFB4"/>
    <dbReference type="PaxDb" id="5476-C4YFB4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01229"/>
    <dbReference type="HOGENOM" id="CLU_1366067_0_0_1"/>
    <dbReference type="OMA" id="YTERHRI"/>
    <dbReference type="OrthoDB" id="3980970at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990593">
        <property type="term" value="F:nascent polypeptide-associated complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039454">
        <property type="entry name" value="OM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039453">
        <property type="entry name" value="OM14_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38402">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN OM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38402:SF1">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN OM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17304">
        <property type="entry name" value="OM14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial outer membrane protein OM14 C-terminal" evidence="3">
        <location>
            <begin position="130"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ43000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="200" mass="21856" checksum="4068BE8248BDE9E2" modified="2010-10-05" version="1">MSSKAPSNEQIKKDVKKDADNIAKKGKEESEHLKKQGKEAVDEASEKGKEFIDQANKKGKELLDEANDKSKEFLKEARKELNHLEEEGQNLLSQFVAYVKSTANSIGQSLNKAGAELQSATSAAVSRTSVELQNPVVIAQIAVAAGGAAAGYLAYLERYRINTDNKYVVGIHASIITGLVVLDGYLFSTYYPKYDKKVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFE6</accession>
    <name>C4YFE6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_01264</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YFE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01264"/>
    <dbReference type="HOGENOM" id="CLU_000443_2_0_1"/>
    <dbReference type="OMA" id="ACFWLFF"/>
    <dbReference type="OrthoDB" id="416585at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000118">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000079">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="633"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
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            <begin position="700"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
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            <begin position="827"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="905"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="938"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="978"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1034"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1074"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1114"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1336"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
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            <begin position="1368"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1405"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1463"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1577"/>
            <end position="1600"/>
        </location>
    </feature>
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        <location>
            <begin position="625"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="907"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="1338"/>
            <end position="1608"/>
        </location>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
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            <begin position="79"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="267"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
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            <begin position="79"/>
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        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ43032.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1652" mass="189853" checksum="67ACCDF03E188B7F" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFQ9</accession>
    <name>C4YFQ9_CANAW</name>
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        <recommendedName>
            <fullName evidence="2">Type 1 phosphatases regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_00035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
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                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
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                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
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                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ41848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="124" mass="14007" checksum="0F52F3A2FC2357AC" modified="2009-07-28" version="1">MSQQRENQRGIVSQTTTTTASPILKLRAQERQARDVSWDANVVDNEHLNKKKTKICCIFHPSDRNCDEEDSSSSSDSSSDSSDNEEDDKNTKIPPKSNNNKKKSKPNAYEVQPHYKNQSKVPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFR6</accession>
    <name>C4YFR6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_00042</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
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                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISP family.</text>
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        <property type="protein sequence ID" value="EEQ41855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFR6"/>
    <dbReference type="SMR" id="C4YFR6"/>
    <dbReference type="PaxDb" id="5476-C4YFR6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00042"/>
    <dbReference type="HOGENOM" id="CLU_035730_3_0_1"/>
    <dbReference type="OMA" id="WRTINIV"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05384">
        <property type="entry name" value="CAP_PRY1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000012">
        <property type="entry name" value="Secreted protein PRY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946742" description="SCP domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="7">
        <location>
            <begin position="122"/>
            <end position="252"/>
        </location>
    </feature>
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        <location>
            <begin position="59"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="67"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009923"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ41855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="271" mass="29078" checksum="7A453B25C4C10D67" modified="2010-10-05" version="1">MKITNTLLNAAALLAVTEAATITKFFTASTQTLFVTQTSQTVVATKSFVETIYSAPPKQLTSKTQDSTSPTTSSVNSLTSSSATSYVETTTPAPSSSTLTTSTISSSTASEDSDATPTADVEFAEEILKEHNVKRALHGVPALSWSNKLAEYAQDYANTGFDCSNLNLKHSGGPYGENLAAGYMGGISPVDAWYDEISMVDWNNVDFTESTGHFTQLVWRSTTQVGCAKMMCSTAWRQITVCEYLPRGNVIGLNVTSGHSYFVDNVLPPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFS0</accession>
    <name>C4YFS0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">U3 small nucleolar RNA-associated protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_00046</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Component of the ribosomal small subunit (SSU) processome.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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            <location evidence="2 12">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:snoRNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="UTP10p Nucleolar protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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    </dbReference>
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        <property type="entry name" value="ARM-like"/>
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="BP28_C_dom"/>
    </dbReference>
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        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056473">
        <property type="entry name" value="HEAT_Utp10/HEAT1"/>
    </dbReference>
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        <property type="entry name" value="U3snoRNP10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
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    </dbReference>
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        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08146">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23243">
        <property type="entry name" value="HEAT_HEATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12397">
        <property type="entry name" value="U3snoRNP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01036">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 12" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 12" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BP28 C-terminal" evidence="13">
        <location>
            <begin position="1534"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="11">
        <location>
            <begin position="1778"/>
            <end position="1816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010559"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00015399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ41859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1818" mass="204383" checksum="EAC1DD7E73816717" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFZ5</accession>
    <name>C4YFZ5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_00108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFZ5"/>
    <dbReference type="PaxDb" id="5476-C4YFZ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00108"/>
    <dbReference type="HOGENOM" id="CLU_474056_0_0_1"/>
    <dbReference type="OMA" id="KIRFFEN"/>
    <dbReference type="OrthoDB" id="4026422at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ41919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="575" mass="65454" checksum="5B05DE911F5658E2" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG70</accession>
    <name>C4YG70_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_119651_0_0_1"/>
    <dbReference type="OMA" id="YEAKFRI"/>
    <dbReference type="OrthoDB" id="2253354at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035213">
        <property type="entry name" value="DUF5321"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17254">
        <property type="entry name" value="DUF5321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ41994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="178" mass="20954" checksum="A03D8B955F9975E2" modified="2009-07-28" version="1">MFSTRVTFRWSLSIRPNILFSRFNSTTAKQYVRQKPKMMDLIRTPTTKSLILTLITSSMIIELMNSKKNLETLINSYNLKFEILLEIIDKLNNNKKFDITKELQLANSFTENKYSSKTDIQMDEQLEQFLKEITQDEGENNQLQQIEVETQVPKDQSIPDIINENIKNSTQEKPKSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGC7</accession>
    <name>C4YGC7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGC7"/>
    <dbReference type="PaxDb" id="5476-C4YGC7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03103"/>
    <dbReference type="HOGENOM" id="CLU_660552_0_0_1"/>
    <dbReference type="OMA" id="ETQGADT"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="416" mass="46192" checksum="87C95291F9703021" modified="2009-07-28" version="1">MKVFGTTYDNVGLFKLKHPAEKWNVKKCIKMFFNDDKSDYSDELLRLAYLPATDYNIEFTILDSEVHNAKRGTRKAYSSRKSTHSYFLIGYNGKSVPKQTRYFLDNHRLTLCSTTKFCTACRTIGHTRWSCVNSSSCLKCGDPSHSTGHHNAWYDRQETDNQDNNDGYTTVGKKRKRKRKSKSNTTSTATANTATATTATANTATATTATATKATATTSTATQATTQADTTKAVTTQATTQADTQPSAIQATTQADTQADTPPSAIQANTQADATEAVTTQADTQSTVQTSDKNNTQKISKVAPSQDVEQLDEINTPSWLASQAMLPIPEAPSQEVELNEGPDKLLFDENEYIETHDYFEPSDFYKSGDDDDYMDEDSEEEDSEEEDSEDDDEMSIDAVSENEIDDLQKENENDQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGM9</accession>
    <name>C4YGM9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homologous-pairing protein 2 winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_03209</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HOP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGM9"/>
    <dbReference type="PaxDb" id="5476-C4YGM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03209"/>
    <dbReference type="HOGENOM" id="CLU_063266_2_0_1"/>
    <dbReference type="OMA" id="RIICKLF"/>
    <dbReference type="OrthoDB" id="4015885at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120231">
        <property type="term" value="C:DNA recombinase auxiliary factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120230">
        <property type="term" value="F:recombinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010774">
        <property type="term" value="P:meiotic strand invasion involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010776">
        <property type="entry name" value="Hop2_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938:SF0">
        <property type="entry name" value="HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938">
        <property type="entry name" value="TBP-1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07106">
        <property type="entry name" value="WHD_TBPIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homologous-pairing protein 2 winged helix" evidence="7">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="82"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ44911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="175" mass="20095" checksum="3FCF3DBE5D1B88C5" modified="2009-07-28" version="1">MAPAKKNQLSTENALASVQVYMQQQYRPYSVSDILLNMHNVLTKPKLITILDTLVADQQLVCKTIGKASYYVYKKQECVLDNTSKTETSECLNQQIKDLKQEICHLKLKLQEIVTTPTNEELDNLIEVYTKKIENLSLELEKCRHNTSVTGAQNELKKYVVQLTKARKERITMVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGQ8</accession>
    <name>C4YGQ8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_03240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGQ8"/>
    <dbReference type="PaxDb" id="5476-C4YGQ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03240"/>
    <dbReference type="HOGENOM" id="CLU_2133155_0_0_1"/>
    <dbReference type="OMA" id="AFRFNTH"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ44940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="113" mass="13504" checksum="2FF6EC2CAB0FB7EC" modified="2009-07-28" version="1">MNFRTIPPILLMELNNMFSNIRWSIGPAFRFNTHSITENNVSRTRIASISEQKKTFRFPFWGNASSSNLHFLSHQKKKKRDYYFCRHLLSTYQSSEYDPRKSKSKYSFCTLFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH15</accession>
    <name>C4YH15_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_03356</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YH15"/>
    <dbReference type="MEROPS" id="M48.018"/>
    <dbReference type="PaxDb" id="5476-C4YH15"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03356"/>
    <dbReference type="HOGENOM" id="CLU_029002_1_0_1"/>
    <dbReference type="OMA" id="RFNCYSE"/>
    <dbReference type="OrthoDB" id="7464992at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M48" evidence="7">
        <location>
            <begin position="136"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ45047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="336" mass="39000" checksum="1198316D9FF5C403" modified="2009-07-28" version="1">MFGSKIFSRLFFKRTYATYKRFDNTTSSSSFTTSYAHLLTNRKTLYIGGGLLGFYVYNLHDAPYTHRSRFIWVPYWLETKIGDYSYRQIYQQFQSQILPHSNPLYNRVSTIMNKLLDVALNDNINDDLNARFLNHLKSLKWEINIIQNDSLPPNAFILPNGKIFIFSSIMPICKNEDGLATVLSHELSHQLAQHSSEQLSKQPIYMVLSTILYTITGVSWFNDLLINGVLTMPASREMESEADHIGCELLARACFNPQESINFWHRMSQAEKKAAGIVSQEGGYLNTWEFFSTHPATSRRIADIQKWMPQLLQIRESSGCYEYGRFYNFNKSYFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH56</accession>
    <name>C4YH56_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_03397</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YH56"/>
    <dbReference type="PaxDb" id="5476-C4YH56"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03397"/>
    <dbReference type="HOGENOM" id="CLU_083354_0_0_1"/>
    <dbReference type="OMA" id="YLICYIM"/>
    <dbReference type="OrthoDB" id="4018368at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ45088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="351" mass="37111" checksum="49086ED024FDF137" modified="2009-07-28" version="1">MKFHMRLQKKFFVLEYYINPDISSFSGKYLFLLFFLFQSHINQLFDYIYFIQRYLICYIMKFLTAASLLTLSSSALAAIKDIQLYAQSSNNEVNDFGISSRHEGAALNYLFLAAPGVAENLKYDDETKTVYTELKAGSSTVRQPLNVGNTVLQLGGSGDGTKVDIAEDGTLSFDGSDSVGAAKNINDPYNYSKDSYAVVKGGDGAIPIKLVAKFTGDDKESASSSSAAAPEPTASSSEAPKETPVYSNSTVTLYTTYCPLSTTITLTVCSDVCTPTVIETSGSVTVSSVQVPSKTASSEAAPPKTTVDSVSKPAPSGEKPTAAVTSFEGAANALTGGSVAIAVAAAIGLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH74</accession>
    <name>C4YH74_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_03416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YH74"/>
    <dbReference type="PaxDb" id="5476-C4YH74"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03416"/>
    <dbReference type="HOGENOM" id="CLU_1825038_0_0_1"/>
    <dbReference type="OMA" id="LALENWH"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ45106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="141" mass="16290" checksum="1F8C1FA49BCDBBA1" modified="2009-07-28" version="1">MLALENWHKVVLVTGNNRNLQDRCLSFQRWLSYFLLLRLTPCLKEMRCTMRRVSNLRGHTTFTSFSSDLLLPLNSTIHNIVTPIPQNILSYTIYTNNTIYKTVSSNPNKSQSFYNDKWVSISLMLGGHKTDQSSALLFTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHQ0</accession>
    <name>C4YHQ0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">F-actin-capping protein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_03599</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
            <location evidence="1 9">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the F-actin-capping protein beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHQ0"/>
    <dbReference type="SMR" id="C4YHQ0"/>
    <dbReference type="PaxDb" id="5476-C4YHQ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03599"/>
    <dbReference type="HOGENOM" id="CLU_045864_1_1_1"/>
    <dbReference type="OMA" id="WSNKYYP"/>
    <dbReference type="OrthoDB" id="9979678at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.570:FF:000001">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000006">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001698">
        <property type="entry name" value="CAPZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043175">
        <property type="entry name" value="CAPZB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019771">
        <property type="entry name" value="F-actin_capping_bsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA ISOFORMS 1 AND 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01115">
        <property type="entry name" value="F_actin_cap_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00192">
        <property type="entry name" value="FACTINCAPB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00231">
        <property type="entry name" value="F_ACTIN_CAPPING_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0117">Actin capping</keyword>
    <keyword evidence="6 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ45282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="291" mass="32925" checksum="4CEDB66A6A6E2D2F" modified="2010-10-05" version="1">MDKFDSSLDLIRRLDPRSITTNLSNICALISEDEELVADLLSSVDTPLTTSTCLKSGKDYLCCDYNRDGDSYRSPWTNVYYPELSSQDVNDAPYPSSILRDLEIKANDSFDIYRDLYYEGGISSVYLWDTSEEDEDVDSTTALQNGFAGVVLFKKETEDKSGNWDSIHVFEVVPQSKNKYLYKLTTSVVLNLENKKQVDGNLGLAGNLTRQLEQEQSIELDGAINPETSHLINLGQLVEKSEYNIRNLLQEVYFDKLKDIMLKDLRSIGDINDKKLDDLKQNAIIKGLQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHQ9</accession>
    <name>C4YHQ9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Phosphomevalonate kinase</fullName>
            <ecNumber evidence="3 14">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_03608</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP</text>
            <dbReference type="Rhea" id="RHEA:16341"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:16342"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 14">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="3 14"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHQ9"/>
    <dbReference type="PaxDb" id="5476-C4YHQ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03608"/>
    <dbReference type="HOGENOM" id="CLU_022059_1_0_1"/>
    <dbReference type="OMA" id="LVIHRTM"/>
    <dbReference type="OrthoDB" id="10262935at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000018">
        <property type="entry name" value="Phosphomevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000069">
        <property type="entry name" value="Probable phosphomevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016005">
        <property type="entry name" value="Erg8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035102">
        <property type="entry name" value="Phosphomevalonate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814:SF2">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017288">
        <property type="entry name" value="PMK_GHMP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="15">
        <location>
            <begin position="144"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR017288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEQ45291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="432" mass="48378" checksum="67F3D92EE74E229A" modified="2009-07-28" version="1">MSKAFSAPGKAFLAGGYLVLEPIYDAYVTALSSRMHAVITPKGTSLKESRIKISSPQFANGEWEYHISSNTEKPREVQSRINPFLEATIFIVLAYIQPTEAFDLEIIIYSDPGYHSQEDTETKTSSNGEKTFLYHSRAITEVEKTGLGSSAGLVSVVATSLLSHFIPNVISTNKDILHNVAQIAHCYAQKKIGSGFDVATAIYGSIVYRRFQPALINDVFQVLESDPEKFPTELKKLIESNWEFKHERCTLPYGIKLLMGDVKGGSETPKLVSRVLQWKKEKPEESSVVYDQLNSANLQFMKELREMREKYDSDPETYIKELDHSVEPLTVAIKNIRKGLQALTQKSEVPIEPDVQTQLLDRCQEIPGCVGGVVPGAGGYDAIAVLVLENQVGNFKQKTLENPDYFHNVYWVDLEEQTEGVLEEKPEDYIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHS6</accession>
    <name>C4YHS6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type 2A phosphatase-associated protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHS6"/>
    <dbReference type="PaxDb" id="5476-C4YHS6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03626"/>
    <dbReference type="HOGENOM" id="CLU_041824_2_2_1"/>
    <dbReference type="OMA" id="EYELCEA"/>
    <dbReference type="OrthoDB" id="10261753at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="45712" checksum="6E97F2648B1D6507" modified="2009-07-28" version="1">MEQLTVAERYKLAIQQYDNLQNISERQDSVSYQKRLTKLISEFKLILQLVEQLSLFSDNEQIEEISTKYIPFLNLWYYIGELYTKLLMKDDDDCDGDDGNIIINLNYKFENLKLGQRFIFTYLENLMNYDDILTLEQSKKLKILLKGESYQLNPMNKRQEKIDNYKLEKELLKKLSILNQEDQKEEDINKFDEEIIRTIYLDQLKYFVLKSFNLLESINMELQVLQHRPTNDDLNSSSSTSSNRLETQDSRSKNKSKKNGGGGDGGDDDDDDYGFTTKLESIPKISYQVSDLINKQGKILQPFTITSQRQKLKEKVFGTGQILPSMTVEEYLDYELANGKMLKDEVKDNNPANKDDNDSDTEDSEAEEEKRRWDDWKDENPKGAGNMKANIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI78</accession>
    <name>C4YI78_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GPI ethanolamine phosphate transferase 3, catalytic subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phosphatidylinositol-glycan biosynthesis class O protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_04150</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI78"/>
    <dbReference type="SMR" id="C4YI78"/>
    <dbReference type="PaxDb" id="5476-C4YI78"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04150"/>
    <dbReference type="HOGENOM" id="CLU_004298_1_0_1"/>
    <dbReference type="OMA" id="EDEYVIM"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000041">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="490"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="520"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="594"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="619"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="658"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="692"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="723"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="800"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="829"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="904"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="940"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="975"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ45813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1015" mass="114861" checksum="EC458BDF2E863211" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIM5</accession>
    <name>C4YIM5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_04301</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIM5"/>
    <dbReference type="PaxDb" id="5476-C4YIM5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04301"/>
    <dbReference type="HOGENOM" id="CLU_058492_0_0_1"/>
    <dbReference type="OMA" id="NMDKRGV"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000454">
        <property type="entry name" value="Ran-specific GTPase-activating protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF142">
        <property type="entry name" value="RAN-BINDING PROTEIN 3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="5">
        <location>
            <begin position="247"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="53"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="154"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="212"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ45960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="385" mass="43124" checksum="A69FBC50DCC8E532" modified="2009-07-28" version="1">MPDESPSKRKIDSDESTSVQLKRTKSIAHDDLRQSIVKEITKTFEERISKLEARISKLEEEFPNEEEEKSEEEKEEEKETKKENAASIDNQQPDRRILNKEPPPLPKRQATFGSNLFSFSPGKITPLNSFNDTNTVPNSPKPVFGATTSFGNMNKLSASSTPEPAKSTITTTSSSSTTLSKPTTSTPATFGSAFGSNTRFSNAFQDSIKKKSFLDKEDDKQSTVDNNNNDKDKENDNNTNNVSKPQEFKQVDLVPVEQTTGEEDEISHFNCTAKIFELNLSKISEGWKERGVGPLHLDQSKADKRQIRLVMRSQGLLRVVLNYKITADTEILKGLEASLTPGKFLRLNSVNSEGTPIQYLLKFGSENLRNELVDKIDALKEQIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIY1</accession>
    <name>C4YIY1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_03793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIY1"/>
    <dbReference type="PaxDb" id="5476-C4YIY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03793"/>
    <dbReference type="HOGENOM" id="CLU_2183566_0_0_1"/>
    <dbReference type="OMA" id="SHHIKRN"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ45465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="109" mass="13045" checksum="4799AB2DD3D156C1" modified="2009-07-28" version="1">MKRTKAKIFFLWRFSLSLQNSNCPKTFLCCSSFFLYKLNLYLILKIKFVFNRFFSHNSLSTLSPFLYHFIEFPFTSTSLSTFKKKEILTVVHTCSKKPNFQSHHIKRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ36</accession>
    <name>C4YJ36_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_03848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ36"/>
    <dbReference type="SMR" id="C4YJ36"/>
    <dbReference type="PaxDb" id="5476-C4YJ36"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03848"/>
    <dbReference type="HOGENOM" id="CLU_030508_1_0_1"/>
    <dbReference type="OMA" id="DSMPDNI"/>
    <dbReference type="OrthoDB" id="276515at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09083">
        <property type="entry name" value="EEP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000196">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF36">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944736" description="Endonuclease/exonuclease/phosphatase domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="45"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ45520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="303" mass="34444" checksum="70A6445A2397BA2A" modified="2010-10-05" version="1">MLSRVVFIILHWTLLVLADSRTTSALDITIYSNNVRYAASRRGRGRDELPWKIRKHGVVDAIKSQSGVDPILIGLQEVTHAQLKDILKGLNKKNSEDDRRWTFFGVGRDNGHKKGEYSPILYNTAEWNLLNGTYKWLSFTPDKPSKYPGASKKRIVTMGTFSHVKTGKVVNFVNTHLDHRSVKSREYSAKLIIQYIKSIPNYFPTFLCGDFNSLDTDKAYATFSHYMVDASHVAEKKYDTNLKTFSGFGNGTSYSIDFIWSPMDTNDNSGTNALSYTVLDNLFDEGHRFSDHRPVMARYSVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ73</accession>
    <name>C4YJ73_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">cAMP-dependent protein kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_03886</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8 9">Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ73"/>
    <dbReference type="SMR" id="C4YJ73"/>
    <dbReference type="PaxDb" id="5476-C4YJ73"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03886"/>
    <dbReference type="HOGENOM" id="CLU_018310_0_1_1"/>
    <dbReference type="OMA" id="SQTRCVG"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12098">
        <property type="entry name" value="DD_R_ScPKA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000039">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000118">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012198">
        <property type="entry name" value="cAMP_dep_PK_reg_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000548">
        <property type="entry name" value="PK_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00394">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0114">cAMP</keyword>
    <keyword evidence="4 9 10" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="220"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="338"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="78"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="125"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ45557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="459" mass="50306" checksum="68E22227601A1060" modified="2009-07-28" version="1">MSNPQQQFISDELSQLQKEIISKNPQDVLQFCANYFNTKLQAQRSELWSQQAKAEAAGIDLFPSVDHVNVNSSGVSIVNDRQPSFKSPFGVNDPHSNHDEDPHAKDTKTDTAAAAVGGGIFKSNFDVKKSASNPPTKEVDPDDPSKPSSSSQPNQQSASASSKTPSSKIPVAFNANRRTSVSAEALNPAKLKLDSWKPPVNNLSITEEETLANNLKNNFLFKQLDANSKKTVIAALQQKSFAKDTVIIQQGDEGDFFYIIETGTVDFYVNDAKVSSSSEGSSFGELALMYNSPRAATAVAATDVVCWALDRLTFRRILLEGTFNKRLMYEDFLKDIEVLKSLSDHARSKLADALSTEMYHKGDKIVTEGEQGENFYLIESGNCQVYNEKLGNIKQLTKGDYFGELALIKDLPRQATVEALDNVIVATLGKSGFQRLLGPVVEVLKEQDPTKSQDPTAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJC6</accession>
    <name>C4YJC6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CAWG_03939</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="CH672350">
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ45610.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="751" mass="85126" checksum="C5ADC0BD67714DD9" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK06</accession>
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        <submittedName>
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        <name type="scientific">Candida albicans (strain WO-1)</name>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
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                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
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                <person name="Staggs R."/>
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                <person name="Srikantha T."/>
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                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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</entry>
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    <accession>C4YK31</accession>
    <name>C4YK31_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
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        <name evidence="13" type="ORF">CAWG_05826</name>
    </gene>
    <organism evidence="13 14">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
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                <person name="Lorenz M.C."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 11">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_093932_1_1_1"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF14">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="12">
        <location>
            <begin position="80"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ47260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="123" mass="13528" checksum="B6D6D64AA162F290" modified="2010-10-05" version="1">MSVVGSLIFCNYCGNLLDSHSSSSEIKCTVCSAAYPKSKFANLKVVTKSSDDAFPSKLKSARSVVKTSLKKDELDEGATIKEKCPKCGNEEMQYHTLQLRSADEGATVFYTCTNCGYRFRTNN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-11-30" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKB8</accession>
    <name>RGI1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>Respiratory growth induced protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RGI1</name>
        <name type="ORF">CAWG_05915</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the control of energetic metabolism and significantly contribute to cell fitness, especially under respiratory growth conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RGI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKB8"/>
    <dbReference type="SMR" id="C4YKB8"/>
    <dbReference type="PaxDb" id="5476-C4YKB8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05915"/>
    <dbReference type="HOGENOM" id="CLU_118207_0_0_1"/>
    <dbReference type="OMA" id="HLKYYPP"/>
    <dbReference type="OrthoDB" id="4082176at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006112">
        <property type="term" value="P:energy reserve metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.40">
        <property type="entry name" value="Respiratory growth induced protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022554">
        <property type="entry name" value="RGI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038235">
        <property type="entry name" value="RGI1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10843">
        <property type="entry name" value="RGI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000402280" description="Respiratory growth induced protein 1">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="201" mass="23654" checksum="759CD16DEC7A47A9" modified="2010-10-05" version="1">MAGKKKSKSEALPLDLDNIKPMDHLQPVPKTRSSSITSIESADEPGTMKQVLLPPTIKEFDELEQFESFVRDETWDNDFDYFHGRLHYYPPFVMKSCQNNLEKIKPTMNKNSKKFRRDLQHHIQKHLIKDLEKCCGYELNFGKGEVVETDNKVTWKFKDETDHGFSKEEEDMYDRHWRLELDVSCTNESAMVDVEYKSIPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKG0</accession>
    <name>C4YKG0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptide hydrolase</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_05963</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M28 family. M28A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKG0"/>
    <dbReference type="MEROPS" id="M28.001"/>
    <dbReference type="PaxDb" id="5476-C4YKG0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05963"/>
    <dbReference type="HOGENOM" id="CLU_024336_0_1_1"/>
    <dbReference type="OMA" id="PNYEYEV"/>
    <dbReference type="OrthoDB" id="10013407at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03876">
        <property type="entry name" value="M28_SGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02130">
        <property type="entry name" value="PA_ScAPY_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000093">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041756">
        <property type="entry name" value="M28_SGAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF17">
        <property type="entry name" value="AMINOPEPTIDASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005125123" description="Peptide hydrolase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="10">
        <location>
            <begin position="189"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="11">
        <location>
            <begin position="299"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ47389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="550" mass="60869" checksum="DF8F7AA633889819" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKH3</accession>
    <name>C4YKH3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 28</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ESCRT-I complex subunit VPS28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_05977</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the VPS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKH3"/>
    <dbReference type="SMR" id="C4YKH3"/>
    <dbReference type="PaxDb" id="5476-C4YKH3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05977"/>
    <dbReference type="HOGENOM" id="CLU_076417_0_0_1"/>
    <dbReference type="OMA" id="CDEFPTV"/>
    <dbReference type="OrthoDB" id="2671at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017899">
        <property type="entry name" value="VPS28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037206">
        <property type="entry name" value="VPS28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017898">
        <property type="entry name" value="VPS28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038358">
        <property type="entry name" value="VPS28_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017535">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140427">
        <property type="entry name" value="VPS28 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51310">
        <property type="entry name" value="VPS28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51313">
        <property type="entry name" value="VPS28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS28 N-terminal" evidence="8">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 C-terminal" evidence="7">
        <location>
            <begin position="155"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ47402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="248" mass="28226" checksum="C7D64A9A52588DE4" modified="2010-10-05" version="1">MTSSPPEYAPTSTSSFTVSTSDVYNQEVTKSSLIKTPLHKSVYDSLAEIYSILPTLEMVENSYLKDYITDKERYTSTTYRLIHQYQMLIKVFTDDQTKFQLLQKEFLPGLLSDMSNFLDLLLSKFNDSYPHAVSRIKNGLPATIEQINGNQPTSASARLVAEITGNFITCMDAVKLNYKSKEQLHPLLSDLVVNLNELNEELQFTGKSKLVNWLIKINNLQTELTQEEADSFLNDLDIAYKGFYTTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKK9</accession>
    <name>C4YKK9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rrp15p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_06015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKK9"/>
    <dbReference type="PaxDb" id="5476-C4YKK9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06015"/>
    <dbReference type="HOGENOM" id="CLU_058264_0_1_1"/>
    <dbReference type="OMA" id="FVKQRFY"/>
    <dbReference type="OrthoDB" id="20949at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012459">
        <property type="entry name" value="Rrp15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245:SF14">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07890">
        <property type="entry name" value="Rrp15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ47438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="28593" checksum="399818840E83E784" modified="2009-07-28" version="1">MVSVNKSKKSTSIKQTNPNTEKKKTAKVVIEEEEQDQSNLSSQEVESEDESDSELEVADNDDLDQEIGSDDEVNIADASSSEGSDASEDENENEEEDFPKLKKRKTKSTEDGSESFADALNSIVNSKLKAYDRKDPILARNKVTLKKLESDKLEMKAKRALLQEKKVLHDNARVKNLLPTSNEPEKVRQVIEKEKALKKVAQRGVVRLFNAVLSTQIKTNQEVNKEKLGQTKKEEIMNEVSKNKFLDLIAAAGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKU0</accession>
    <name>C4YKU0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TRUD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_06098</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKU0"/>
    <dbReference type="PaxDb" id="5476-C4YKU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06098"/>
    <dbReference type="HOGENOM" id="CLU_005281_0_2_1"/>
    <dbReference type="OMA" id="WINYFGH"/>
    <dbReference type="OrthoDB" id="447290at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02576">
        <property type="entry name" value="PseudoU_synth_ScPUS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.20:FF:000011">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00094">
        <property type="entry name" value="tRNA_TruD_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRUD" evidence="4">
        <location>
            <begin position="410"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ47519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="758" mass="87042" checksum="7E9083007B7F11F2" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL57</accession>
    <name>C4YL57_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_01572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL57"/>
    <dbReference type="PaxDb" id="5476-C4YL57"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01572"/>
    <dbReference type="HOGENOM" id="CLU_1042056_0_0_1"/>
    <dbReference type="OMA" id="PMGPRGC"/>
    <dbReference type="OrthoDB" id="10670740at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946850" evidence="2">
        <location>
            <begin position="19"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ43338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="293" mass="25264" checksum="14826E839D19D9DD" modified="2009-07-28" version="1">MRVSTLVLSTSIIPIATALNISPFHNIEKKDILADAASAAGGAAAAVTSGAVGAANTVASGAAGAADTATSGAAGIANTVASGAAGAADTATSGAAGAAKTATSGAAGAADTATSGAVGAAKTATSGAAGAADTATSGAAGAAKTATSGAAGAASGAETAAGAAASGAETAAAGQETSGAGSLVGGSGSSNSTSPSGGSGSSNGTSSGSGSGSGAGVGSGSGSGSGSRGSITGNSVATGASSGPAGLGISSSISQSTTRQLQTSGSSNSSSSAGMGNVVVGMNAVALAALVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL60</accession>
    <name>C4YL60_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Karyogamy protein KAR4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_01575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MT-A70-like family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL60"/>
    <dbReference type="PaxDb" id="5476-C4YL60"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01575"/>
    <dbReference type="HOGENOM" id="CLU_046318_0_0_1"/>
    <dbReference type="OMA" id="FNSELYQ"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045123">
        <property type="entry name" value="METTL14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107:SF0">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51592">
        <property type="entry name" value="SAM_MTA70L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ43341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="369" mass="42448" checksum="C36D0603AFAF1642" modified="2010-10-05" version="1">MYTYNKFGSRASSSTSSTNNTISSSNYATRTSSRTTETNEKNNLVKIKKETVDYCNHYVHTGEPGVKFIRNVKNPLEGYPKLAKLHHLKRLQIKKHTSQAYGVRCTTGEIVPTLNRWIENYNIRFDVIMIGALVENQFILPILNSIPIHRLCSKPGFLFIWATTQKIQELTRLLNNDNFNKRFRRSEELIFLPIDDKSPYYPHDSGATEVIPLFERQQWHCWMCITGTVRRSTDNHLIHCNIDTDLQIESPSDKTKQKSTYNAVPEAIYRVAENFSNSNRRLHLVPSKLGYSTPIRLRAGWVIMGPDVLINNFDPVKYNEELYAKSMIKYKPNNGIAANTNTTTTTQFLVPQTNEIEDLRPKSPIISTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL69</accession>
    <name>C4YL69_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U three protein 23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_01584</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in rRNA-processing and ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UTP23/FCF1 family. UTP23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL69"/>
    <dbReference type="PaxDb" id="5476-C4YL69"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01584"/>
    <dbReference type="HOGENOM" id="CLU_053567_1_1_1"/>
    <dbReference type="OMA" id="CCMQALY"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09865">
        <property type="entry name" value="PIN_ScUtp23p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000006">
        <property type="entry name" value="rRNA-processing protein UTP23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057776">
        <property type="entry name" value="UTP23_sensor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24779">
        <property type="entry name" value="UTP23_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP23 sensor motif region" evidence="9">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="177"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ43350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="269" mass="30880" checksum="571167BC6BD2D013" modified="2009-07-28" version="1">MRQKRAKAYKKQMSVYVHAFKFREPYQIIVDNELITTCQSASFDINKGFTRTIQAENKPMITQCCIQALYDTKNQPAIDIAKSFERRKCNHREAIDPSQCIESIVNIKGQNKHRYIVASQDLQLRKKLRKIPGVPLIYMNRSVMVMEPISDVSNQYNMNYESKKLTGGLNDIEAGKLEKQNEGEDGDGDESEVKKKKRKGPKEPNPLSVKKKKTDNATAASTNQEQKKKPNRRKRHGKSKAEEKEDQEQEQVNIATTNEDEQETITATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL86</accession>
    <name>C4YL86_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_01603</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL86"/>
    <dbReference type="PaxDb" id="5476-C4YL86"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01603"/>
    <dbReference type="HOGENOM" id="CLU_091755_0_0_1"/>
    <dbReference type="OMA" id="ILHDQIT"/>
    <dbReference type="OrthoDB" id="332281at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="8">
        <location>
            <begin position="27"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ43367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="281" mass="32937" checksum="2B0E5AB4621FD142" modified="2009-07-28" version="1">MSQEFDILNGTDEFPYPTSIIQTDFKNFDSDSHEIDLFLYKNYRFSSIDSIIKELTELSTNLNQNLLDLVNDDYHDFIDLGKSINDGLDLINAIVEDLKNFEIELVNYYKKFSDLDNRLYQILQNRKFLNNLKTCIKLNLILHDQITEFDNCMNNQIQEENNIQGLNQLKTLTSLYLSINNIEIFLNKFIQLGNIDDVNNSIDNNDHDNNNGNHRVNSPFHDNYINNKIASIKLEFKSYLDQLIRKELKKKTRNSQIMIELLNIYKLIGEEKSVMSIISSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLG4</accession>
    <name>C4YLG4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLG4"/>
    <dbReference type="PaxDb" id="5476-C4YLG4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01682"/>
    <dbReference type="HOGENOM" id="CLU_542928_0_0_1"/>
    <dbReference type="OMA" id="HEYQPII"/>
    <dbReference type="OrthoDB" id="4093447at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="499" mass="54855" checksum="5B5232025D81F4F4" modified="2010-10-05" version="1">MINKNLNLSLKLNKLDFVPPNSNFGGSSSPFTPVDQTLKTPLEAPQHQTEFPLQHQFQSQQQGYHGNVNQSSLYQNPEVNESDDILTDIDEPCNLTRRNFTLFFTNQFDQVLISIYSTILSLPTTTPFSGNIPPSGLVSKVANETIKELIRVTSASKNTPIYDQFNIINSDCLRSHEYQPIILQLIRKRLLEICHSKNNSVNKLPESTSISLNSTVTRNSSVSNLSLSDMNLMNYNNSNQNNTAVNLARSRSSSINLRKQSLTRNNSNNWLHVGNINNLRPSGNPDFNMSTDSLQSFQDFVPQSIINRTSNGSGNANVTNNSNNLVSSSSNVGQLNSMMMDYHITPPTSHKGSISSTNSPYNIVHNPCTSDSEEFQFLQRSRSSSRGNNLPQALNINTDMSNLQALNSLQGNSGNSKYVQPGLSLDSPFLSATTPGDEYFSGPSFANPSNNSTTAVISAGSNSVENAEAGGDTSKANLPNQYSLSEKKRDSLKMKRGIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLU2</accession>
    <name>C4YLU2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerases I, II, and III subunit RPABC3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_01811</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the eukaryotic RPB8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLU2"/>
    <dbReference type="SMR" id="C4YLU2"/>
    <dbReference type="PaxDb" id="5476-C4YLU2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01811"/>
    <dbReference type="HOGENOM" id="CLU_103864_1_0_1"/>
    <dbReference type="OMA" id="KEDDKGW"/>
    <dbReference type="OrthoDB" id="20018at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000191">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005570">
        <property type="entry name" value="RPABC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03870">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000779">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00658">
        <property type="entry name" value="RPOL8c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ43573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="148" mass="16781" checksum="952FCF20CC0DE317" modified="2010-10-05" version="1">MSGILFEDMFIVDSTDPGRYNKVCRITGHSSTSKDITITLDINKELFPVQNHDSLTITLASSLGNESSMITSNGSWRPPKPDERSLADDYDYVMYGTVYKFEENADNDKMAVYISFGGLLMRLEGGYRSLSNLKQENAYILIRHYKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLY3</accession>
    <name>C4YLY3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_01855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLY3"/>
    <dbReference type="SMR" id="C4YLY3"/>
    <dbReference type="PaxDb" id="5476-C4YLY3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01855"/>
    <dbReference type="HOGENOM" id="CLU_042569_4_0_1"/>
    <dbReference type="OMA" id="ACMTAKC"/>
    <dbReference type="OrthoDB" id="2573163at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF21">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ43614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="352" mass="40528" checksum="E44F906E8AC5F37B" modified="2010-10-05" version="1">MVLIVVDVLRKKNFDTGVVMNNITTSQMQPFKNKVGGHTPIFSISKQEICKELNNTERNFYKKISKNHPLFYYMPRYKGSNGSQIILEDLTSQMRTPCILDLKMGTRQYGCNATITKQQSHRAKARSTTTRKLGVRICGLQIFNYQNKYFYQDKYLGRKITVGKQFGKILAKFLYNGHDIYSLLNRIPHLIDQLKELYTIFTGLPGYRMYGSSILLMYEGGEDNSENQVKVKIIDFANAVIAGEENIDNVTVPPQHPDSPDLGYLRGLNSLIVYFTLIFSILSRIKLNNTKEMVDWIQENKQTLKEQSCPWLDDYAELDGLKDGSIHQDMCDDPFDIEYPEYTPEEDEGLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM09</accession>
    <name>C4YM09_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_01884</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM09"/>
    <dbReference type="SMR" id="C4YM09"/>
    <dbReference type="PaxDb" id="5476-C4YM09"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01884"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_1_1"/>
    <dbReference type="OMA" id="IMIFTDT"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17955">
        <property type="entry name" value="DEADc_DDX49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="32"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="247"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="405"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEQ43640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="440" mass="48832" checksum="5A2483E47C9368DB" modified="2009-07-28" version="1">MSFNDLGVAKWLSESLDAMKIYTPTAIQSACIPAILKGHDCIGGAKTGSGKTIAFAAPMLTQWSEDPFGIFGLILTPTRELALQIAEQFAALGANMNIKVAVVVGGEDFVQQTLALQRKPHFVIATPGRLADHILNSGEETISGLRRVKYLVLDEADRLLSNSFGSDLQRCFDVLPTSDKRQTLLFTATITDAVRALKEKPPTPGKPPVFMHEVETVDKVAIPSTLQISYVFVPSYVKEAYLNSILHLEQFKDSTAVIFVNRTTTAEVLRRMLRKLDFRVASLHSEMPQSERTNSLHRFKAGAARILIATDVASRGLDIPTVELVINFDIPADPDDFIHRVGRTARAGRKGDAVSIIGEKDIDRIQSIEERINKKMELLEDVNDDNVIKESLSATSVAKRESLMEMDKENFGERKKINRKKHGLDKVKPERVTKPKKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM47</accession>
    <name>C4YM47_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Very-long-chain 3-oxoacyl-CoA reductase</fullName>
            <ecNumber evidence="12">1.1.1.330</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">3-ketoacyl-CoA reductase</fullName>
            <shortName evidence="12">3-ketoreductase</shortName>
            <shortName evidence="12">KAR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Microsomal beta-keto-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_01922</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="EC" id="1.1.1.330"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endoplasmic reticulum membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.330" evidence="12"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM47"/>
    <dbReference type="PaxDb" id="5476-C4YM47"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01922"/>
    <dbReference type="HOGENOM" id="CLU_010194_38_0_1"/>
    <dbReference type="OMA" id="LVAPGMM"/>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045703">
        <property type="term" value="F:ketoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141040">
        <property type="term" value="F:very-long-chain 3-oxoacyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000317">
        <property type="entry name" value="Very-long-chain 3-oxoacyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03107">
        <property type="entry name" value="3_ketoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027533">
        <property type="entry name" value="3_ketoreductase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0521">NADP</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ43678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="408" mass="45258" checksum="4B3143D4CA597156" modified="2009-07-28" version="1">MFLISDTLNVVCKFRTTTRASFPPTEKNCWCFSKKKRDGRKTHTHKSPSFLKHTTNNLKMPFTQFLDKYSDNLAIQYAIIFALLLGVFKLTVFSLKFASLIYDIFLAPATDFSKYGAASGKWAVVTGASDGIGKEYAFQLAKKGFSIVLVSRTQSKLELIATEIESKYKVNTKIVAFDASTDDEENYLKLEKAVFDLPVTILINNVGQSHSIPVPFLKTEKKELKDIITINTTATLRITQIVAPIIVSTVENPHPKQLRGLILTMGSFGGLLPTPYLATYSGSKSFLQTWSAALAGELQADHVDVELVISYLVASAMSKIKRTSLSIPNPKQFVTSTLNGVGRRNGAQERFATSTPYWTHALMHFAIDNTVGVYSKIANKLNLQMHQSIRQRALKKAARLAAAAEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM90</accession>
    <name>C4YM90_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2',3'-cyclic-nucleotide 3'-phosphodiesterase</fullName>
            <ecNumber evidence="3">3.1.4.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_01968</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the metabolism of ADP-ribose 1',2'-cyclic phosphate which is produced as a consequence of tRNA splicing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2H phosphoesterase superfamily. CPD1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.37" evidence="3"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM90"/>
    <dbReference type="PaxDb" id="5476-C4YM90"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01968"/>
    <dbReference type="HOGENOM" id="CLU_088289_0_0_1"/>
    <dbReference type="OMA" id="FEPHITI"/>
    <dbReference type="OrthoDB" id="514292at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009187">
        <property type="term" value="P:cyclic nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012386">
        <property type="entry name" value="Cyclic-nucl_3Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28141">
        <property type="entry name" value="2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28141:SF1">
        <property type="entry name" value="2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07823">
        <property type="entry name" value="CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ43721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="224" mass="25718" checksum="1891BE85A7FD28DB" modified="2009-07-28" version="1">MSSLNTLFPGSPPKFEPHITITTNISLDLADQSKTKDDVDRILSASAVAMNSLPKNHESLVKLGNVNSQRKFFKKLYFEVEKDPNLVSFARIIRELFVIVPQDIEKENIKQNPQLYTKDNNGNTIRRKPSKKKSKTTEVKEFDTSFIRQAAAYKAAEWSVQEFDPHISLVYSDLWPLHSALWRNINTRISDIDWDIEWEFGVLKLVLCEGDVNDWVVLGSVDIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YME3</accession>
    <name>C4YME3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_02022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YME3"/>
    <dbReference type="PaxDb" id="5476-C4YME3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02022"/>
    <dbReference type="HOGENOM" id="CLU_1106980_0_0_1"/>
    <dbReference type="OMA" id="TNKSWEQ"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF27">
        <property type="entry name" value="PHO85 CYCLIN CLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="29336" checksum="2C11D78943C937FE" modified="2009-07-28" version="1">MDKEYQEYQISDMPSFIGWACHGILKQNRTTSEFLLNSTQSLLFSTRLSIPTILAGLEYINQRFSNKEVYHLQDQEIFQILVVSFLLSNKMNDDATFTNKSWEQASGIPLSVLNREEREWLNEVKFNLAVTKYEANISVLDQCWKTWVNKYGSCHSEPPSSPTYYTPEVDAYYYSSHHHSYSSPISYSQHSYSNPYPQHQQCNYQYQYQPQYQPTYQSHTQYLVPQPPPPPPLSYYDPAIVSVNYGGFIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YML2</accession>
    <name>C4YML2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YML2"/>
    <dbReference type="PaxDb" id="5476-C4YML2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02095"/>
    <dbReference type="HOGENOM" id="CLU_362080_0_0_1"/>
    <dbReference type="OMA" id="GMHELVM"/>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="194"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ43843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="773" mass="86206" checksum="22CB013B730E228B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMS2</accession>
    <name>C4YMS2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3,2-trans-enoyl-CoA isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_02156</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMS2"/>
    <dbReference type="PaxDb" id="5476-C4YMS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02156"/>
    <dbReference type="HOGENOM" id="CLU_009834_6_2_1"/>
    <dbReference type="OMA" id="FQAIMDF"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000048">
        <property type="entry name" value="3,2-trans-enoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ43903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="34390" checksum="0B548DACFB1DF840" modified="2009-07-28" version="1">MKKNIYINSISYLYFSLSNSPKVSKLLYTMSDEEADVLYEVRDRTAIITFNIPSKLNALNGEQYLKLGKFMERANEEEGTVMTLIQSTGRFFSAGANFADNGLMDVDPQLLFTHEYWLGKFVARNVWLTNLFNDHKKILVAAVNGPSIGLSTGLLMLVDLVYVHDLSKFYLLAPFANLGLVAEGAASATLFARLGWSKASEALLLAKPISGADCYNVGLINKHYDGKFKSTEEFNQQVYKEVTDAFENLHEDSILQNKQLLKLNRDQYINHANSQEVMRGLGKWLEGVPQTRFVQLANKDVKHKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMW4</accession>
    <name>C4YMW4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-lysine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class V-like SAM-binding methyltransferase superfamily. RKM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMW4"/>
    <dbReference type="PaxDb" id="5476-C4YMW4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02201"/>
    <dbReference type="HOGENOM" id="CLU_030667_1_0_1"/>
    <dbReference type="OMA" id="FLWSHLI"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19180">
        <property type="entry name" value="SET_SpSET10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017119">
        <property type="entry name" value="Efm1/Rkm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044432">
        <property type="entry name" value="Set10/Efm1_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF147">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037136">
        <property type="entry name" value="Ribosomal_Lys-mtfrase-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="71"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ43945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="579" mass="67247" checksum="68C1B5A20D1636DD" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNQ8</accession>
    <name>C4YNQ8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_02840</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNQ8"/>
    <dbReference type="PaxDb" id="5476-C4YNQ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02840"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="OMA" id="KWAMYLF"/>
    <dbReference type="OrthoDB" id="648285at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:001249">
        <property type="entry name" value="Sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF73">
        <property type="entry name" value="METABOLITE TRANSPORT PROTEIN YDL199C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="495"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="554"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="620"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="200"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="28"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="672"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="672"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ44567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="750" mass="84153" checksum="A2D869A63F4D2740" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNT3</accession>
    <name>C4YNT3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_02866</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNT3"/>
    <dbReference type="SMR" id="C4YNT3"/>
    <dbReference type="MEROPS" id="T01.010"/>
    <dbReference type="PaxDb" id="5476-C4YNT3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02866"/>
    <dbReference type="HOGENOM" id="CLU_035750_5_2_1"/>
    <dbReference type="OMA" id="TFIYGYC"/>
    <dbReference type="OrthoDB" id="7854943at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03762">
        <property type="entry name" value="proteasome_beta_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000010">
        <property type="entry name" value="Proteasome subunit beta type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 11 12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ44592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="214" mass="23301" checksum="7CF114B886A29DF4" modified="2010-10-05" version="1">MNGISVDINHLKKGEVNLGTSIMAVTFKDGVILGADSRTTTGSYIANRVTDKLTQIHDTIYCCRSGSAADTQAVADMVKYYLQIYSSQLPPGETPTTNIAANVFQEICYNNKDNLTAGIICAGYDRKNGGSVYSIPIGGSIHKQNYAIAGSGSSYIYGWCDENYKPSMEQEQCVEFVKTALSQAIKWDGSSGGLIRMVILTKNGVERRVVYLHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNZ7</accession>
    <name>C4YNZ7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_02931</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NSE2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNZ7"/>
    <dbReference type="PaxDb" id="5476-C4YNZ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02931"/>
    <dbReference type="HOGENOM" id="CLU_088986_0_0_1"/>
    <dbReference type="OMA" id="IELICPI"/>
    <dbReference type="OrthoDB" id="756301at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16651">
        <property type="entry name" value="SPL-RING_NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026846">
        <property type="entry name" value="Nse2(Mms21)"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330:SF1">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11789">
        <property type="entry name" value="zf-Nse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="11">
        <location>
            <begin position="180"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ44656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="272" mass="31353" checksum="4C765CFA6A065503" modified="2009-07-28" version="1">MPQTLDDAPDEVLPSNLSLPASIPLKRELLREYEDQFRDTTTDSLFRDQILQTKQMAEYYIDYILENDHLNFSEKILQQYLNAFENFMKLEGKLNKLKQVRNLPTIEGYSSNLTSLTLDNLDNQHTLNQVYFPEAIKEEYAKLGVPTISDSTITKQGYQFLKQVLFSFKNPEDAIPDETEDDELNVSGGKISLKDPLTLNYFVKPVKSKRCNHVYEESSILLHLNTQRVCPISGCSAVLTRNDLILDKLMLIRIRSVNRVERHDDGNMETVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPB3</accession>
    <name>C4YPB3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPB3"/>
    <dbReference type="SMR" id="C4YPB3"/>
    <dbReference type="PaxDb" id="5476-C4YPB3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03065"/>
    <dbReference type="HOGENOM" id="CLU_150785_0_0_1"/>
    <dbReference type="OMA" id="HNYLANV"/>
    <dbReference type="OrthoDB" id="4094421at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="110" mass="12500" checksum="CEB26A69A13DFC44" modified="2010-10-05" version="1">MSTPKNNEDKPESSKDFDINDLVKLESITQKVLDPNNENPHMGEYIKGTFSYIANAMIKMQTTNDRQATAKEIAEDLSQKFDDWVKSREAAKENQSAEDTTANKIEESKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPC6</accession>
    <name>C4YPC6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_03079</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPC6"/>
    <dbReference type="SMR" id="C4YPC6"/>
    <dbReference type="PaxDb" id="5476-C4YPC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03079"/>
    <dbReference type="HOGENOM" id="CLU_642486_0_0_1"/>
    <dbReference type="OMA" id="NDQGSPK"/>
    <dbReference type="OrthoDB" id="1939603at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167:SF4">
        <property type="entry name" value="FUNGAL N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="186"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="261"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ44785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="401" mass="45319" checksum="6E08F8AADC0A45A7" modified="2010-10-05" version="1">MSSDKPEQEILDPKDSKNASLNSTTKKSQDSKLMLPPLGVKSEQQQPQQQQQTPLYGQQGSPQVQTQPQFQADYSYANYQPQAQFYDPYQRQVIMQQANFASPSQYPIQQPYSFANGMTNMAQFHPQTLTSHSDFDQQQMQQSTQPSQQVQVQVQIQPQSNSNSFPAEQKRGRRFRRRFNQIERKYPCSFPGCQKSYGSLNHLNTHIVTKKHGHRKSKADFQHSLQSKEENKPSEISQYVQPSNDYTAGNYWYGYAPHLRSTTSTTSSQSDSFNSQQIPQQPQQQQQQQPQQQNNSNNYLYYQGFQQPITNATTVSGATPATSTLTPAGTASASLSHQPQIQNPASASTVPQQRMVMGNMGYYQQQGAPQYFPAPQQSLLGINDVDSRNQIDDNKPTQPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPH6</accession>
    <name>C4YPH6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_02377</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPH6"/>
    <dbReference type="PaxDb" id="5476-C4YPH6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02377"/>
    <dbReference type="HOGENOM" id="CLU_006220_0_0_1"/>
    <dbReference type="OMA" id="MSHCKHT"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000156">
        <property type="entry name" value="Ribonuclease Z, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13691">
        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNase Z endonuclease" evidence="11">
        <location>
            <begin position="5"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ44114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="857" mass="97483" checksum="D24F2F15E61353C7" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPH8</accession>
    <name>C4YPH8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPH8"/>
    <dbReference type="PaxDb" id="5476-C4YPH8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02379"/>
    <dbReference type="HOGENOM" id="CLU_1326219_0_0_1"/>
    <dbReference type="OMA" id="GRRNCAS"/>
    <dbReference type="OrthoDB" id="4009884at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="209" mass="22806" checksum="E6E9FC931CA111AD" modified="2010-10-05" version="1">MAETNPNDNSPKSLPLRRHSDVLVNTGTTYSATTPNSLNEGNSISSHRELIIPSSAGGRQQSPVLDLVHPISSGNLTTTSQETRTRNCISWCSGLFNFRNSSQQTAENSSLLPVYHVRSNTSPTDSAGMTSNLSDFIRRLLPGLARDRYPNTFSWLLATLLTIVLIAATLGLYFSGNLSGLLVLFRALVCSVFRQFQPSDVALPLFCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPK4</accession>
    <name>C4YPK4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_02405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="RBBP5/Swd1"/>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
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        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040:SF1">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
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    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="EEQ44143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="447" mass="51416" checksum="86BA6AA566D67C90" modified="2009-07-28" version="1">MNLSLQDPFSVAKEFPETLTNTLNYGHSVAIQFNHKGDYLASGLSDGSIVIYEMVSSGVIAHLNQYCHIRPITSITWSKCGRYLLTSSQDWWVKLWDLSKVNITDAKDIDESPVIREVKFDGPIWSACMHPTNPFVFTASLFEDSPVYVDFTAKDQPPQITRLTTTPLEMNEPTEGDNEEEIARKRRKKMEKHMTLVSIFTHEGNYIFTGTSKGWLNIFDTTSSNLNLVRSIKIANPNIKNLMISQNGRKLAVNSSDRIIRQIDLPDLINVEDSNDWDFEIDHKYQDVVNRLQWNSVSFNHNAEFLVASTHGQSSHDLYLWETSMASLVKILEGSNEELVDVKWNYSRCTIGSIGLDSGIIYLWSVQFPQKWSALAPDFVEIEENIEYLEKEDEFDIIDEDELHKKRLEEEDYVADVLKMDTTDARGFDITQDSFIIPINYEKNFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPK6</accession>
    <name>C4YPK6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_02407</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
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            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="SMR" id="C4YPK6"/>
    <dbReference type="PaxDb" id="5476-C4YPK6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02407"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="term" value="C:cell septum"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="755"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="795"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="826"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="878"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1000"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1058"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="12">
        <location>
            <begin position="309"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="214"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ44145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1106" mass="125763" checksum="E16E9B3BFF1E3A30" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPN6</accession>
    <name>C4YPN6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPN6"/>
    <dbReference type="PaxDb" id="5476-C4YPN6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02437"/>
    <dbReference type="HOGENOM" id="CLU_2291291_0_0_1"/>
    <dbReference type="OMA" id="SIRKCHW"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="101" mass="11786" checksum="13448A51CA64037D" modified="2009-07-28" version="1">MTDTITFLRTCIVTTSSSIEQKDNIKFDVIALLLHHPIVILCRVTIVFAPPAVLFDSLLKPFFPTSIRKCHWKIYTLVHLNSLFQKRYTLTHLIRRSHHTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPP0</accession>
    <name>C4YPP0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPP0"/>
    <dbReference type="PaxDb" id="5476-C4YPP0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02441"/>
    <dbReference type="HOGENOM" id="CLU_1532330_0_0_1"/>
    <dbReference type="OMA" id="GATMIKL"/>
    <dbReference type="OrthoDB" id="4065753at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="143"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="175" mass="20009" checksum="E6189008C1DC293D" modified="2009-07-28" version="1">MNLFSKLDNNESNKESNLILFSDFLPEVLSFTTSENERIQDLYLQLCSLFNHHSYNEILFLLPQLSSFSMLPAIINLIIGATMIKLGRLDSGFRELAVAIIMSSRGEQRISFLIVAATLHAELNDRERVQGYLGEILDLSRQVVQSSEEFDIVKENLEELENTLLIKLENVKDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPV3</accession>
    <name>C4YPV3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CAWG_02507</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="17">Component of the 850 kDa m-AAA protease complex, a heterohexamer composed of YTA12/RCA1 and YTA10/AFG3. Associates with the prohibitin complex, composed of PHB1 and PHB2, inhibiting the activity of the m-AAA protease complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPV3"/>
    <dbReference type="MEROPS" id="M41.002"/>
    <dbReference type="PaxDb" id="5476-C4YPV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02507"/>
    <dbReference type="HOGENOM" id="CLU_000688_16_2_1"/>
    <dbReference type="OMA" id="YDKQGGG"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097002">
        <property type="term" value="C:mitochondrial inner boundary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000019">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1690.20:FF:000007">
        <property type="entry name" value="ATP dependent metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="20">
        <location>
            <begin position="319"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="43"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="754"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="754"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="778"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00065348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EEQ44242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="795" mass="88800" checksum="0252FCF753187E20" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ11</accession>
    <name>C4YQ11_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_02565</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ11"/>
    <dbReference type="PaxDb" id="5476-C4YQ11"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02565"/>
    <dbReference type="HOGENOM" id="CLU_054407_0_0_1"/>
    <dbReference type="OMA" id="NSEMTDY"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="276"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ44300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="392" mass="44676" checksum="81E1064EA4C4DB65" modified="2009-07-28" version="1">MIIPMTIECGHSFCYDCIYQWFSNKINCPTCRHDIENKPILNIHLKEICHKIIESIIENTSNGDGDGDSGGVDHLMNRKLECLKTYNLDVKNKSIFGDLFNNTVTTLIDCSDGVARCGNCHWEVHGSICSHCGTRFRRSTRNINGESEEDEDEEEDDDEDAFEDVVAGFRQSVEINEYDSDDSFIDSRTANEIPVGTDSDSEISIHINTNNNNNNNNNGNVYDNESNENNNTDDDDEEEEEYGNNHLGHTESFGNNSAIHDDWHGFESATSSVIDRAFSDDDEEEVVDEEEEDVSIQRSMNSPYNNDSIELSSSEHENIIQLSGDDEDDSYYDSEDIRDAMEEMDNFNIDNTDYSNEEDDDVVELSDYNSYSDNMISDVDNDNDDDDDECWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ18</accession>
    <name>C4YQ18_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxidase</fullName>
            <ecNumber evidence="14">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_02572</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 Fe(II)-[cytochrome c] + H2O2 + 2 H(+) = 2 Fe(III)-[cytochrome c] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.11.1.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Forms a one-to-one complex with cytochrome c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="14"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ18"/>
    <dbReference type="SMR" id="C4YQ18"/>
    <dbReference type="PaxDb" id="5476-C4YQ18"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02572"/>
    <dbReference type="HOGENOM" id="CLU_036959_1_1_1"/>
    <dbReference type="OMA" id="QRKWNGP"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004130">
        <property type="term" value="F:cytochrome-c peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000023">
        <property type="entry name" value="Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF58">
        <property type="entry name" value="CYTOCHROME C PEROXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 14 17" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="16">
        <location>
            <begin position="173"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ44307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="366" mass="40682" checksum="59860ED332DB3EDA" modified="2009-07-28" version="1">MATFAPHISKITKSSTKFNYGRIAKTFLGVAGSAAIATYFYNNGNPFNNNNNNNNNNGGSKNAAKALFGASAGANVKIAKVPEGKSASDYQKVYNDIATKISENLEFDENAGYYGQLLRLAWHTSGTYDKSDNSGGSYGGTMIFAPEEFDPENAGLQVGREFLMEFLVKYPWISRGDLWTLGGVAAVQESGGPKIEWRPGRVDDNTASKVPPNGRLPDASKDGKYVKDLFARMGFNERETVALLGAHVLGRCHKHNSGYDGPWGPSFNQFTNVFYTTLLGDWHVKKWDGKKQYEDDETGEFMMLPTDMALKEESYFLKYVKMYADDQDLFFKDFAKAFSKLISNGIKYPADSKPILFKTLDEQDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ59</accession>
    <name>C4YQ59_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Kre5p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_02613</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000310">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02613"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_transf_24"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
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        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UGGT_TRXL_3"/>
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        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946707" description="Kre5p" evidence="7">
        <location>
            <begin position="23"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="8">
        <location>
            <begin position="44"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="9">
        <location>
            <begin position="277"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="10">
        <location>
            <begin position="442"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="11">
        <location>
            <begin position="1137"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1420"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1420"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1438"/>
            <end position="1447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ44348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1447" mass="166137" checksum="65224AD984216740" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ70</accession>
    <name>C4YQ70_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_02625</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ70"/>
    <dbReference type="PaxDb" id="5476-C4YQ70"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02625"/>
    <dbReference type="HOGENOM" id="CLU_356374_0_0_1"/>
    <dbReference type="OMA" id="DATYGTC"/>
    <dbReference type="OrthoDB" id="4026800at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025928">
        <property type="entry name" value="Flocculin_t3_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052479">
        <property type="entry name" value="GPI-anchor_Adhesion_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185">
        <property type="entry name" value="SERINE/THREONINE-RICH PROTEIN ADG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185:SF1">
        <property type="entry name" value="UPF0619 GPI-ANCHORED MEMBRANE PROTEIN C1322.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13928">
        <property type="entry name" value="Flocculin_t3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944869" evidence="7">
        <location>
            <begin position="19"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="356"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="439"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="241"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="372"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="440"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ44359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="787" mass="78563" checksum="6E2A597F61BF0007" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQJ2</accession>
    <name>C4YQJ2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">13 kDa ribonucleoprotein-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_02750</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 13">Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the U3 snoRNP particle. Binds to the C'/D and B/C motifs in U3 snoRNA. Component of the 25S U4/U6.U5 tri-snRNP particle, a subcomplex of the spliceosome. Binds to the 5' stem-loop of U4 snRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
            <location evidence="1 13">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQJ2"/>
    <dbReference type="SMR" id="C4YQJ2"/>
    <dbReference type="PaxDb" id="5476-C4YQJ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02750"/>
    <dbReference type="HOGENOM" id="CLU_084513_4_1_1"/>
    <dbReference type="OMA" id="IKNQIYA"/>
    <dbReference type="OrthoDB" id="1924699at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21104">
        <property type="entry name" value="SNU13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="14">
        <location>
            <begin position="19"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ44481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="126" mass="13601" checksum="15E80E88AFC2AB14" modified="2009-07-28" version="1">MSAPNPKAFPLADSALTQQILDVVQQSQNLRQLKKGANEATKTLNRGISEFIIMAADTEPIEILLHLPLLCEDKNVPYVFVPSKAALGRACGVSRPVIAASVTSNDASSIKNQIYGIKDKIETLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQJ4</accession>
    <name>C4YQJ4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_02752</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the nucleoporin Nup85 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQJ4"/>
    <dbReference type="PaxDb" id="5476-C4YQJ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02752"/>
    <dbReference type="HOGENOM" id="CLU_019986_0_0_1"/>
    <dbReference type="OMA" id="VKHYSWM"/>
    <dbReference type="OrthoDB" id="17644at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011502">
        <property type="entry name" value="Nucleoporin_Nup85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373">
        <property type="entry name" value="FROUNT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373:SF21">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07575">
        <property type="entry name" value="Nucleopor_Nup85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU365073"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="EEQ44483.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="773" mass="89650" checksum="B284EE68DF9BECDE" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQK5</accession>
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            <fullName evidence="2">DUF2423 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">CAWG_02764</name>
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        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pichiomycetes</taxon>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
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                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
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                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="YBL028C_N"/>
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        </location>
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            <begin position="85"/>
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    </feature>
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    </evidence>
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            <dbReference type="Pfam" id="PF10338"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ44494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="100" mass="11809" checksum="2C4E57F0937C91C5" modified="2009-07-28" version="1">MAKSLRSKSKLQAKSTKRKGEFSKYVEERSKRIANRLAEETKKQEEAKKQQDPTQTQTEAMDIEDNKDKKVSTSGWRDSRSQVYKQRKLKNKNKKKTLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQV8</accession>
    <name>C4YQV8_CANAW</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">CAWG_04455</name>
    </gene>
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        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
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                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4095869at2759"/>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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    <feature type="region of interest" description="Disordered" evidence="2">
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    </feature>
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        </location>
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    </feature>
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    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="590"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="615" mass="69093" checksum="C92C1BD5EDA0CD38" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQX6</accession>
    <name>C4YQX6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04473</name>
    </gene>
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        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
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                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
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                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
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                <person name="Berriman M."/>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces N-formyl-kynurenine through the oxidation of tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
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            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04473"/>
    <dbReference type="HOGENOM" id="CLU_010089_0_0_1"/>
    <dbReference type="OMA" id="SNKIMEP"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:heme binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Indoleamine 2,3-dioxygenase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF5">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00876">
        <property type="entry name" value="IDO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ46129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="440" mass="49798" checksum="22420FDDB74016A0" modified="2010-10-05" version="1">MTIPNIEEFDVFPNSGFLPSKLPLERLPQEYYQPWENIVNNLPSLILTKRIRAIIDKLPVLETTHLTSDEEYRRAYQILGFLAHAYIWGTDTPTDKLPSQIATPWIKVSDHLGLPPIATYASLCLWNFKQIMPSDDIWDLDNLTTINTFTGSIDESWFYLVSVYFEHKGALAITTGLDAIKCAYDNNTKGLVENLQQLAEAIDSLGSVLMKMEEMCDPHVFYFRIRPYLAGWKNMTEVGLKGVYYGEEKTVRNYAGGSNAQSSLIQFLDILLGVKHYSTGERPLPFKASTGVGAENGFMNEMREYMPGNHQKFLSKIQEITNINQYVLDHKDSHPELVLSYDACLAMLKSFRDKHIQIVTRYVVLQAKKTEKMGSSSTLRSGLARKKKEERGTGGTSLLPFLKQCRDETGDPAAGNWGQRILSDGVMRLKFSKPNGINED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR33</accession>
    <name>C4YR33_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_04532</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR33"/>
    <dbReference type="ESTHER" id="canal-q59nw6">
        <property type="family name" value="Carboxypeptidase_S10"/>
    </dbReference>
    <dbReference type="MEROPS" id="S10.001"/>
    <dbReference type="PaxDb" id="5476-C4YR33"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04532"/>
    <dbReference type="HOGENOM" id="CLU_008523_10_4_1"/>
    <dbReference type="OMA" id="IYTDKEC"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006522993" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ46186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="498" mass="56308" checksum="3B0C9A49DD5164EA" modified="2009-07-28" version="1">MKALLLLYTVITVVLALPSQTPFSLSPLQQIKDELAGKVSQKQILDMERIWINYQRQYGLETILKEFNQFKSQFQYSLASQDKSESTYSIEVSKASPELLGFDTVKQYTGYFNVNDKDKNYFFWFFESRNDPKNDPLVIWLNGGPGCSSLCGLALELGPSIINATLQPEYNPHAWNSNASVLFLDQPANVGFSYGGNIPITSDQASQDFVEFIKLFYERFPEYVDLDLHISGESYAGHYVPSFANAVHKAGIPLNSILIGNGVTDPVVQLGEKSNMGCGQGGIGKIYTDKECTEYPEKYEKFVPYGELCYKNPNALTCFIAALASPKTPDTGDLNPYDSRVKCGNNSLCYDQTDYLNDYFNLQSVQEALGVEKTYTMCSSNVGSRFVSDFMRPYHTYVADLLDDGIPVLIYVGDKDLVCDWLGNLAWVNKLNYTGHDQFEKTEFKPWYTADGKLAGEVKNHDHFTYLRIYESGHMVPMDQPENSLDMVNRWVRGDFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRB0</accession>
    <name>C4YRB0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Threonine synthase</fullName>
            <ecNumber evidence="5">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_04609</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-homoserine + H2O = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:10841"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="5"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRB0"/>
    <dbReference type="PaxDb" id="5476-C4YRB0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04609"/>
    <dbReference type="HOGENOM" id="CLU_015170_1_0_1"/>
    <dbReference type="OMA" id="NFERYLY"/>
    <dbReference type="OrthoDB" id="5203861at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01560">
        <property type="entry name" value="Thr-synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000046">
        <property type="entry name" value="THR4p Threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1380.10:FF:000003">
        <property type="entry name" value="THR4p Threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="entry name" value="Threonine synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051166">
        <property type="entry name" value="Threonine_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690">
        <property type="entry name" value="THREONINE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690:SF1">
        <property type="entry name" value="THREONINE SYNTHASE-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24857">
        <property type="entry name" value="THR4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Threonine synthase N-terminal" evidence="14">
        <location>
            <begin position="8"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="13">
        <location>
            <begin position="97"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ46263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="510" mass="57681" checksum="EEA918A7D9647979" modified="2009-07-28" version="1">MPSSSQVYRSTRSSQPEELSFEDVVMTGLAPDGGLYLPSAIPQLPKDFLSKWADLSFNELAFEILRLYINENEIPNADLKDLITRSYSTFRSSEVTPLKKLDDNLYILELFHGPTYAFKDVALQFVGNLFEYFLTRRNAQKDLTKQPRDIITVVGATSGDTGSAAIYGLRGKKDVSVFILYPTGRISPIQEEQMTTVEDENVHTLSVNGTFDDCQDIVKSVFGDKEFNDKYHVGAVNSINWARILAQQTYYFYSYFQLQKQAKTTNKVRFVVPSGNFGDILAGYYAYRMGLPVDKLIIATNENDILDRFIKSGEYAKEQEVGVKATYSPAMDILISSNFERLLWYLIRDNVPEVNKSDEKAGQLLNDWIKQLKEQGKFKVPAEVIDAARQVFDSQRVDNDTTVQTIKQVYDKSADKYVIDPHTAVGVTTSYSFIAKDTEPIQYISLSTAHPAKFSEVVNKALDSFDGYSFDKDVLPAELKALSSKEKRIKLIDEASVEKVKQAIKDELKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRE2</accession>
    <name>C4YRE2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SLS1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YRE2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04641"/>
    <dbReference type="HOGENOM" id="CLU_012168_0_0_1"/>
    <dbReference type="OMA" id="LWFELDE"/>
    <dbReference type="OrthoDB" id="5392646at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048401">
        <property type="entry name" value="SLS1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20778">
        <property type="entry name" value="SLS1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLS1 C-terminal" evidence="2">
        <location>
            <begin position="420"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="766" mass="87990" checksum="A89747F1C586101E" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRE5</accession>
    <name>C4YRE5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04644</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRE5"/>
    <dbReference type="PaxDb" id="5476-C4YRE5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04644"/>
    <dbReference type="HOGENOM" id="CLU_024990_0_0_1"/>
    <dbReference type="OMA" id="RTHKGDI"/>
    <dbReference type="OrthoDB" id="79252at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012921">
        <property type="entry name" value="SPOC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462:SF3">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07744">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="6">
        <location>
            <begin position="74"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="324"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="606"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="340"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="634"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ46298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="670" mass="77617" checksum="D6588E710B01E82B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRL6</accession>
    <name>C4YRL6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial 54S ribosomal protein YmL20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_04717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRL6"/>
    <dbReference type="SMR" id="C4YRL6"/>
    <dbReference type="PaxDb" id="5476-C4YRL6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04717"/>
    <dbReference type="HOGENOM" id="CLU_089054_1_0_1"/>
    <dbReference type="OMA" id="PEKYTRK"/>
    <dbReference type="OrthoDB" id="6021263at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024388">
        <property type="entry name" value="Ribosomal_mL58"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12824">
        <property type="entry name" value="MRP-L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="20611" checksum="2FA1AC6739A1B52E" modified="2010-10-05" version="1">MIRTSIRRVSTKSIPYEPIPKNKYNQVRSAYNFKPAKNDGFVYSPPAAIIKPQMITPYIFLPENDPRRELAKQHRIDPKIVAEMPIIRQINAPHERQYNVDADTINKIKELRAADPERWTLKEISKEFNIEMDKLHFFLRSQFPKKPTEPVKVVSKKLLDRQKRKQLWLRNQY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRP9</accession>
    <name>RCF1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>Respiratory supercomplex factor 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RCF1</name>
        <name type="synonym">AIM31</name>
        <name type="ORF">CAWG_04752</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with the respiratory chain complex III/complex IV supercomplex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RCF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRP9"/>
    <dbReference type="SMR" id="C4YRP9"/>
    <dbReference type="PaxDb" id="5476-C4YRP9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04752"/>
    <dbReference type="HOGENOM" id="CLU_087356_1_0_1"/>
    <dbReference type="OMA" id="YYRTERT"/>
    <dbReference type="OrthoDB" id="6604018at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF3">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000399623" description="Respiratory supercomplex factor 1, mitochondrial">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="3">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="89"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="155" mass="18126" checksum="805F6B6B26BE205D" modified="2009-07-28" version="1">MSVRLPSSMSYGEEEEPDVLQKMWDKSKQQPFVPLGSLLTAGAVLLAARSMKRGEKLKTQRYFRYRIGFQLATLVALVGGGFYYGTETSQHKQTREDKLREKAKQREKLWIEELERRDAIIQARKQRLEESKKELRELAKQGFIEEKESNDKKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRV3</accession>
    <name>C4YRV3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_04810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRV3"/>
    <dbReference type="ESTHER" id="canaw-c4yrv3">
        <property type="family name" value="Steryl_acetyl_hydrolase"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YRV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04810"/>
    <dbReference type="HOGENOM" id="CLU_053543_0_0_1"/>
    <dbReference type="OMA" id="QSYWIVE"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010424">
        <property type="entry name" value="EutQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019436">
        <property type="entry name" value="Say1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169:SF1">
        <property type="entry name" value="ACETATE KINASE EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169">
        <property type="entry name" value="ETHANOLAMINE UTILIZATION PROTEIN EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10340">
        <property type="entry name" value="Say1_Mug180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="43097" checksum="15E8D58EDF8F146F" modified="2009-07-28" version="1">MYKDDLSNSLKMILYRTLIDFPKDDIHIFALMSTGFVINSVVGKLDSSLTSKLPNYGKKFDKQSYWIVEKPNRKPDDPVLIYLHGGGYFLGIVPQQIESMVTTYYLLDASKRENLSILVLDYNLTCQGYPIPHQLSQLVETYSNLVKNGAENLLLMGDSAGGNLAVTFTQYLRLSNSVNLPYPKSCVLISPWVKLIAETYQNTPGHSYYNYSKVDMLHFDTFSSADLYKHILGDTKLNSLTVSPGNCPYDPKDWDDISTYKQPGHSVFVLAGEHETFRDDILEWSKCVLDYPIDKLDFKDSNGEFDPKAHRYIRNDANSAYVDVTIVPWGPHDYLYFDHSLIGKLKSEPTLKLNSINKRKYFATISVVNFLNTVLPGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRZ2</accession>
    <name>C4YRZ2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRZ2"/>
    <dbReference type="PaxDb" id="5476-C4YRZ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04850"/>
    <dbReference type="HOGENOM" id="CLU_094334_1_0_1"/>
    <dbReference type="OMA" id="NNMYRIT"/>
    <dbReference type="OrthoDB" id="4068385at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022592">
        <property type="entry name" value="Nucleolar_19"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10863">
        <property type="entry name" value="NOP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="232" mass="26186" checksum="E71A7D05A556636B" modified="2009-07-28" version="1">MIHYCQLSSNSTSHPYLIMSRRSEIKQKQELQARFQLAMSANNQKALNWLKPLKSTASTTSTSSETPNANNPTSDDSFMDLQIIPQGASLSKLDNLQKIGDFINSKDITKMKQSTTTTTTASNLTSNRVTKSKPMLALMNKMRDSNRKNVRQNQHHHQQQQQSTSSINGKSNKPMIPNKSQSIVKNYNNEEEDDEDSRAIRSRTVKKGSSLLLENKLNNKNSGTKKKNVRPF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-11-30" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSG0</accession>
    <name>CCM1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>Mitochondrial 15S rRNA processing factor CCM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CCM1</name>
        <name type="ORF">CAWG_05026</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Involved in mitochondrial-nuclear incompatibility, a major determinant in reproductive isolation between species, through hybrid incompatibility of Ccm1 and its interacting partner 15S rRNA between yeast species.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSG0"/>
    <dbReference type="SMR" id="C4YSG0"/>
    <dbReference type="PaxDb" id="5476-C4YSG0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05026"/>
    <dbReference type="HOGENOM" id="CLU_019745_0_0_1"/>
    <dbReference type="OMA" id="ESSAIWA"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0508">mRNA splicing</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000402257" description="Mitochondrial 15S rRNA processing factor CCM1" evidence="2">
        <location>
            <begin position="91"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR 1" evidence="3">
        <location>
            <begin position="276"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR 2" evidence="3">
        <location>
            <begin position="311"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR 3" evidence="3">
        <location>
            <begin position="349"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR 4" evidence="3">
        <location>
            <begin position="384"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR 5" evidence="3">
        <location>
            <begin position="420"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR 6" evidence="3">
        <location>
            <begin position="636"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="588"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="588"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="599"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P48237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="770" mass="88722" checksum="754D6D37E32CBE9A" modified="2009-07-28" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSQ2</accession>
    <name>C4YSQ2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_05120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSQ2"/>
    <dbReference type="PaxDb" id="5476-C4YSQ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05120"/>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_1"/>
    <dbReference type="OMA" id="GHMAIMI"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="19"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ46755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="369" mass="40239" checksum="CE504707635D8F42" modified="2009-07-28" version="1">MTTDSVPAKFQGFASSNKNTWNKPKLVSYDRKQINPHDVVLENEVCGLCYSDIHTLQSNWGEYNRDDLVVGHEIVGKVIAVGDKVTEFKVGQRVGIGAASSACRECNRCKSDNEQYCAKAASTYNAPDVRSNNYVTQGGYSSHSIADEQFVFPIPDDLPSAYAAPLMCAGITVFSPLLRNLGSDAKGKTVGIIGIGGLGHLALQLAKALGAKVVAFSRTSSKKDQALKLGADEFIATNEEKDWSSKYHDTFDFILNCASGVDGLNLQDYLSVLKVDKKFISVGLPPATQQFGVSPFTFLKHGASFGSSLLGSKVEVLEMLKLAAKHNVKPWIEEVPLSEENCSKALNRCHDGDVRYRFVFTEFDKAFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSX8</accession>
    <name>C4YSX8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-dependent RNA helicase DOB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_05673</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSX8"/>
    <dbReference type="PaxDb" id="5476-C4YSX8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05673"/>
    <dbReference type="HOGENOM" id="CLU_002902_0_1_1"/>
    <dbReference type="OMA" id="IMLKNYN"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000003">
        <property type="entry name" value="ATP dependent RNA helicase (Dob1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="149"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="388"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="350"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ47114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1062" mass="120505" checksum="4CC17E0AF292242B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT13</accession>
    <name>C4YT13_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sla2p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_05711</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLA2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT13"/>
    <dbReference type="PaxDb" id="5476-C4YT13"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05711"/>
    <dbReference type="HOGENOM" id="CLU_004601_0_0_1"/>
    <dbReference type="OMA" id="FQMSVEM"/>
    <dbReference type="OrthoDB" id="10262320at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
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        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Myosin rod fragments"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="7">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
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        <location>
            <begin position="813"/>
            <end position="1058"/>
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        <location>
            <begin position="255"/>
            <end position="306"/>
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    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="323"/>
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    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="400"/>
            <end position="620"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ47149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1063" mass="120757" checksum="DC4BA705D7477F35" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTD1</accession>
    <name>C4YTD1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_05418</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTD1"/>
    <dbReference type="PaxDb" id="5476-C4YTD1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05418"/>
    <dbReference type="HOGENOM" id="CLU_001882_1_2_1"/>
    <dbReference type="OMA" id="FIHIPDG"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10306">
        <property type="entry name" value="GST_C_GluRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000004">
        <property type="entry name" value="Glutamyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000036">
        <property type="entry name" value="Putative glutamyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="entry name" value="Glutamyl-trna Synthetase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.800.10">
        <property type="entry name" value="Glutamyl-tRNA Synthetase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041103">
        <property type="entry name" value="GluRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18466">
        <property type="entry name" value="GluRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate--tRNA ligase N-terminal" evidence="16">
        <location>
            <begin position="23"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="14">
        <location>
            <begin position="215"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="15">
        <location>
            <begin position="523"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="17">
        <location>
            <begin position="625"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ46872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="725" mass="82525" checksum="4D378DA7612EF794" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTD4</accession>
    <name>C4YTD4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoinositide 5-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_05423</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptojanin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="3"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTD4"/>
    <dbReference type="PaxDb" id="5476-C4YTD4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05423"/>
    <dbReference type="HOGENOM" id="CLU_003016_2_0_1"/>
    <dbReference type="OMA" id="QHPCFEL"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000164">
        <property type="entry name" value="Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF257">
        <property type="entry name" value="PHOSPHOINOSITIDE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="6">
        <location>
            <begin position="152"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="909"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="920"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="970"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1008"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1054"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1070"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1107"/>
            <end position="1118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ46875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1143" mass="127995" checksum="405A8BBE71EC4659" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTI2</accession>
    <name>C4YTI2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_05475</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTI2"/>
    <dbReference type="PaxDb" id="5476-C4YTI2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05475"/>
    <dbReference type="HOGENOM" id="CLU_016218_0_2_1"/>
    <dbReference type="OMA" id="GDWESCK"/>
    <dbReference type="OrthoDB" id="10249309at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000017">
        <property type="entry name" value="eIF2B 34 kDa alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1070:FF:000002">
        <property type="entry name" value="Translation initiation factor eIF-2B subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ46923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="311" mass="35100" checksum="56EF4A92DDC112A6" modified="2009-07-28" version="1">MADFDIKETYLKFLEEDKDMTMPIAAIESLVSMLKAKSPSTSSELINLVSKNIDLLKSSIPNNISLSAGCDLFMRFVLRNTNVYSDWESFSQNLVENGELFVQRAKESRLKSAEYGVPFIKDDDVILVHSYSRVVYSLLLKAKQEKLIRFKVLVTESRPTGNGYYMARKLKEADIPVEVIVDNAVGYVLHKVDKILVGAEGVAESGGVINHIGTYQIGCLAKVNNKPFYVVTESHKFVRLFPLAPNDLPNSISHFDYDENRTEELNHGGQELFETRFVDFTPHEYITALITDLGVLTPSAVSEELIKIWYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTL9</accession>
    <name>C4YTL9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease</fullName>
            <ecNumber evidence="9">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_05514</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="9"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTL9"/>
    <dbReference type="PaxDb" id="5476-C4YTL9"/>
    <dbReference type="HOGENOM" id="CLU_036532_0_1_1"/>
    <dbReference type="OMA" id="RYSWQTA"/>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.460:FF:000001">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000016">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="10">
        <location>
            <begin position="150"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ46960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="427" mass="47787" checksum="BFCE044020CCB85B" modified="2009-07-28" version="1">MFSHYLGRRVLNCFRATTPACLFTLIPHSFLPQKLFFQIDLSDLVPSSFFCRSYIEKFDNMASAIALESPDTVLLDASLKRKVDEVTEDTPTTTESVEATESDTNKRSKLAISLDWLPPSVTNIEDPFKFASSTYHSEIPQSVLQNKTEPIVLGVDEAGRGPVLGPMVYGIAYSLESFSSKLQKEYGFADSKVLTDVKREELFKQIEDPDHELHKHIGWATTTMTARDISSGMLQSVNGKGAYNLNEQAHDTTINLIKQVLAKGVKISKIFVDTVGPPVTYQAKLKRFFPEIDVTVTKKADSIYPIVSTASVVAKVTRDTNIKFYNENLPLLQGQKLGSGYPSDPNTSKWLNSNVDPVFGWCYGFIRFSWQTAKDSLVKNNAAEVVYEDQGKGVEKGYQDVFAMIDKKKDNSKLKRNYFCSSNVNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTW9</accession>
    <name>C4YTW9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitochondrial peroxiredoxin PRX1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_05615</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTW9"/>
    <dbReference type="PaxDb" id="5476-C4YTW9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05615"/>
    <dbReference type="HOGENOM" id="CLU_042529_4_2_1"/>
    <dbReference type="OMA" id="HGPMNIP"/>
    <dbReference type="OrthoDB" id="2996783at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF4">
        <property type="entry name" value="PEROXIREDOXIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="49"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="7">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ47060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="265" mass="30062" checksum="58F6D2514C50CEB7" modified="2009-07-28" version="1">MQHHVTFSQQKKTIYIFLLILADERQKTNKKKKSFFFATHTTMSQQPHLRLGSTAPDFKADTTNGPISFHEYIGDSWAILFSHPAARTSVCSTELSAFARLEPEFTKRGVKLLAISADPVEANSDWIDDMEDFSGSRVKFPIIADAERKVATLYDMIDHQDATNLDDKGLQLTIRAVFIIDPSKKIRLIMTYPASTGRNTAEVLRVLDSLQLVDKQKVITPINWVPGDDVLVHMGVPDDEARVLFPKYRAIKPYIRLTPLEKEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTY8</accession>
    <name>C4YTY8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine amidotransferase type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTY8"/>
    <dbReference type="SMR" id="C4YTY8"/>
    <dbReference type="PaxDb" id="5476-C4YTY8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05636"/>
    <dbReference type="HOGENOM" id="CLU_042555_4_0_1"/>
    <dbReference type="OMA" id="SVHPAWN"/>
    <dbReference type="OrthoDB" id="14446at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061672">
        <property type="term" value="C:glutathione hydrolase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01908">
        <property type="entry name" value="YafJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000045">
        <property type="entry name" value="Glutamine amidotransferase DUG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052373">
        <property type="entry name" value="Gamma-glu_amide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187:SF1">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ47079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="344" mass="38666" checksum="A0ACC25D441DC464" modified="2010-10-05" version="1">MCRFMIYKGREEMVLSDLLTKPAHSIINQSFDSRLRLDMRNPVNGDGFGVGYYSENRHPCIFKAITPAWNNVNLNNLAECTESSLVFAHVRASTQGVLAETNCHPFSYGKIMFMHNGGVSAFNLIKKKLINHLEDKFFLHIQGSTDSECCFALFVDTLYKMGYDPEDLSVKFSHSILRKALLTTIDLIKTWQCQVTNEPSLLNFAATDGESIVVSRYITSKTDEAASLHFSTGSKFFEYQPGLFKMERLNRSQDVIFVSSEPLTFERGDWLCVPTNTILTITNRNTVLMHPIEDEFYDGEVQRSSGLAMSKGLIGGVPMKDVEVDSTLAEVPPLDREGRVAVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C5K454</accession>
    <name>C5K454_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_06157</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG670282">
        <property type="protein sequence ID" value="EEQ43136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C5K454"/>
    <dbReference type="PaxDb" id="5476-C5K454"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06157"/>
    <dbReference type="HOGENOM" id="CLU_013929_4_2_1"/>
    <dbReference type="OrthoDB" id="4033386at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="42"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ43136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="369" mass="42459" checksum="B13DEA52B2DAEF78" modified="2009-07-28" version="1">MAKAISDIKNGLLLSYRKAAKKYNLCHETIRKRMNGVLPKQIAHRGKQLFTPQQEKEIVKWIIESDEAGNGRSRHDIVEYAELFLSLDRQSASIGGSWFERFKKRHKEIHVVQGRKISSLRVKAATPDQIKEYFHKYDSIVRQHQIPNENIFNYDESGFIMGQGKSSRVAVPSYKNRTYVKSTEGRDSCTVIEAINMSGEKLIPGIIFKGQTLRTGWFNDDASDYYYSVSKCGYTSYWLSWRWLEEVFIPQVKEKTNQGKVLLIMDGHGSHKTKKFRETCEDNNIIPLYLPPHSTHLLQPLDLGIFGPIKYGYKVKLSKLAHALGTDPVKQQLFLSNYYEARQEKLDSKKESFDPGKSSALIHLMLTKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCT7</accession>
    <name>C4YCT7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_00321</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCT7"/>
    <dbReference type="PaxDb" id="5476-C4YCT7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00321"/>
    <dbReference type="HOGENOM" id="CLU_039466_2_1_1"/>
    <dbReference type="OMA" id="GEHFKYL"/>
    <dbReference type="OrthoDB" id="190958at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ42123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="227" mass="27105" checksum="A41A506B330F1108" modified="2009-07-28" version="1">MTENTTPYYKKQASYQDKRYTINKSNLIEPIIRHRIQDSLFYKQHLYLSNEATILPIIIEHVHYIGGTDSSNRPSTFISCLFRLLELEPSKEIIKTYLTQLDFNEFKYLTALTLIYIRLTYPSQEVYSIFDQYFQDFRKLRIKLKTPVFDSQKLPIHYKITFIDEWVDTLLVDERVIDLMLPRLIPRTTLVERGQLAPRQYYIDISDEEEKDAGEEEEDDDYESDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCX8</accession>
    <name>C4YCX8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_00362</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCX8"/>
    <dbReference type="PaxDb" id="5476-C4YCX8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00362"/>
    <dbReference type="HOGENOM" id="CLU_120080_0_0_1"/>
    <dbReference type="OMA" id="MVYYSIS"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF1">
        <property type="entry name" value="LOW AFFINITY AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ42164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="18063" checksum="FC25AE288EB68D51" modified="2009-07-28" version="1">MIPCGPMGVVAAIDGAILLMKVPSAVVMFLAMMAFFIGIVIMGTRPVGQIYWAQKFVSLLIQPIGMDMSFPAACILLSSSLPRHQQGIAGSLVSTFVNYSISIGLGFAGTVEYYTTKNKEPNLSTSIFGMRNAFRMGMGLAGVGVVLSSIFMLLQIINRRKSTRSQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD52</accession>
    <name>C4YD52_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_00442</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:12045"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD52"/>
    <dbReference type="SMR" id="C4YD52"/>
    <dbReference type="ESTHER" id="canal-LIP3">
        <property type="family name" value="Fungal-Bact_LIP"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YD52"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00442"/>
    <dbReference type="HOGENOM" id="CLU_029538_5_0_1"/>
    <dbReference type="OMA" id="SAWAAEM"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946699" evidence="5">
        <location>
            <begin position="17"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ42238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="471" mass="51195" checksum="44167CCF30A8470C" modified="2009-07-28" version="1">MKTLVVLCTLLSIIFASPLSLKSPLVDDFYNPPRGYESAKLGEILKLRKTPGKISSLFIPVEVKNSWQLLVRSEDSFGNAAAIVTTVIEPFNADPSKVVSYQSWEDAANIECSPSYGMQFGAPLSSVQTQVDMIFIVPLLDKGCFVVLPDYEGPKSTFGVGRQSGKATLDSIKAVLKTKDFSGINDDAQVAMWGYSGGTIAAGWAATLQPKYAQELKKNLIGAALGGFVINITATAEATDGTLFAGLIPNALNGLANEFPDFKKRMYEVVEKRYEGALQQGTQHCLGGAILHFAFDQVFTGDHRYFEQGYGLLEEEVFNRTISGNSLLYMGQEYLPDIPIFVYHGSLDGIVPIPDVHGVYKNWCDWGIDSFEFAEDSLNGYLTEIVVGAPAAITWLDARFDGQPVVEGCKKTTRITDFSYPNISDSTRNFFKGILDSLTASQLGPGVTSDNVTLSGLTGFMGGLSKFKKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD53</accession>
    <name>C4YD53_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_00443</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD53"/>
    <dbReference type="SMR" id="C4YD53"/>
    <dbReference type="PaxDb" id="5476-C4YD53"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00443"/>
    <dbReference type="HOGENOM" id="CLU_087132_1_1_1"/>
    <dbReference type="OMA" id="FGTSCIC"/>
    <dbReference type="OrthoDB" id="277109at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="BUD31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411:SF0">
        <property type="entry name" value="PROTEIN BUD31 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PROTEIN BUD31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="BUD31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00322">
        <property type="entry name" value="G10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ42239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="150" mass="17053" checksum="46169BB92E0AE8A7" modified="2010-10-05" version="1">MPKIKKPKKNGPPPEGYSKIEPTLTKYRNKLKSAQANPDPTKSKQSSLWIIYQLNYKITRYVYDTYVAKRISKELYDWLLLQNDINKDLIAKWKKPGYEKLCCINCISTNTNGGGTCVCRVPKAKLLEKDPEKVNIECITCGCRGCASSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDB7</accession>
    <name>C4YDB7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_00507</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDB7"/>
    <dbReference type="PaxDb" id="5476-C4YDB7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00507"/>
    <dbReference type="HOGENOM" id="CLU_025894_2_0_1"/>
    <dbReference type="OMA" id="GDVYAWY"/>
    <dbReference type="OrthoDB" id="10027823at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520:SF5">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="24"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ42303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="457" mass="49698" checksum="F7364974D9FB05A8" modified="2009-07-28" version="1">MSEGWISFLIDEIGLYTLSNAGTDVYIIILLRMIRLIGFGATSLILALFLKSLGIPEQYIGLFMTLTFIGDLVSSFLLSIITDQIGRKKMLLACSVLMTLTGAVFGLSENYYVLVVTAILGILTPSGGEVGPFRTVEQSSIASLVPHEKRSDIYAWYTFLGTFCAAFGSFLAGALIDIVQDNYGFTIVQSYKCVFWVYTLLSGICVILCLFITGNIEVKPDPGLEEPATTPEDNESEPTETSQLIPTTGNVTNKPKNKFRLLPHLSPDTYLLVIKLSLLFGLDSFASSLTPISWISYYIKNKFDVPSSYLGSVFFTTGFVSGFTSLGSTPLTKRFGAVVTMVFTHLPASILLALVPLPSSFSLTMGILVVRACTQTMDVAPKHVFLATLVSDSDRTAVFGFVNVVKTLAQVVGPSIVGVITQRGAQWISFVIAGSLKATYDIGMLVTFLTYNRHAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDF4</accession>
    <name>C4YDF4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Alkaline phosphatase</fullName>
            <ecNumber evidence="3 15">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_00548</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="3 15"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDF4"/>
    <dbReference type="PaxDb" id="5476-C4YDF4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00548"/>
    <dbReference type="HOGENOM" id="CLU_008539_6_0_1"/>
    <dbReference type="OMA" id="KAAGYMT"/>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019637">
        <property type="term" value="P:organophosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alkaline phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000063">
        <property type="entry name" value="Alkaline phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
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        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 13 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="12">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ42340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="551" mass="60663" checksum="1BEAE5EF0CA9CFA1" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDU5</accession>
    <name>C4YDU5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">4-nitrophenylphosphatase</fullName>
            <shortName evidence="5">PNPPase</shortName>
            <ecNumber evidence="3 5">3.1.3.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_00693</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21664"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57917"/>
            <dbReference type="ChEBI" id="CHEBI:61146"/>
            <dbReference type="EC" id="3.1.3.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Divalent metal ions. Mg(2+) is the most effective.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.41" evidence="3 5"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDU5"/>
    <dbReference type="SMR" id="C4YDU5"/>
    <dbReference type="PaxDb" id="5476-C4YDU5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00693"/>
    <dbReference type="HOGENOM" id="CLU_043473_0_0_1"/>
    <dbReference type="OMA" id="PPMHRET"/>
    <dbReference type="OrthoDB" id="413953at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000039">
        <property type="entry name" value="Phosphoglycolate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006349">
        <property type="entry name" value="PGP_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01452">
        <property type="entry name" value="PGP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ42481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="308" mass="34240" checksum="245E824BDE2F762F" modified="2010-10-05" version="1">MSIKITSKDQVNQLLDKYDYFLFDCDGVLWLGDHLLPSIPEAISLLRSKNKQVIFVTNNSTKSRNDYLKKFEKLGIPDISKQEIFGSSYASAIFIDKILKLPKDKKVWVLGEKGIEQELHELGYTTVGGSDPDLISSGVDFDSNDPRLNKLDNDVGCVLCGLVFNLNYLKLSLTLQYLLKDKKTIPFIATNIDSTFPANGKLLIGAGSIIETVSFASGRQPEAICGKPNQSMMNSIKADFPDLGKTPKRGLMIGDRLNTDMKFGRDGGLDTLLVLTGIETEENVKSLNENETPTYYINKLGDFHELNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDZ5</accession>
    <name>C4YDZ5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_00744</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">WO-1</strain>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="291" mass="33574" checksum="676447F77F38ED4E" modified="2009-07-28" version="1" fragment="single">MENEIVQVFSIVDESWWSGKLRRNGAEGIFPKDYVTILEDKLNHSMSSLSLQDGRTTPTKQMDDHSRRSAGTTPLGNFSKLKTSQSFANDSIEYDQDHSFNQSFDDRYSKPFTPTKGNVRSSKYMSSAMNHPKNKLTYQQQEELLRKKEKEIEYFRSMQQQQNYQVKPKVNDSKRLSFQHTHHSSPDVASRLHQMDYTSPTSIKSPSYGDVPHSQNGKYQHLLNNYVATSDSTPTKTSKRATMASYEPEFLDEFDEIAKKKAQLEIELERLKQLEKLSKKAAIRSPIQKDS</sequence>
</entry>
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    <name>C4YE03_CANAW</name>
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        </recommendedName>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
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                <person name="Sakthikumar S."/>
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                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
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                <person name="Brunke S."/>
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                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
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                <person name="Quail M.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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        </location>
    </feature>
    <feature type="short sequence motif" description="FFD box" evidence="1">
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        </location>
    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
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            <end position="106"/>
        </location>
    </feature>
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    </feature>
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        </location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51536"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ42539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="37741" checksum="88C8E6F67580EC0C" modified="2009-07-28" version="1">MSQYIGKTISLISNKGLRYVGLLENINADDATVALKSVRLFGTEGRMAAMGQPNLEVPPGVDVYDYVVFRGSDVKDLSVLDTPIDEVKPNIYRPPQQQQQGATTGQYYSGPTSTSSQNGTPQTQTQAPATTSTTTASQSYGQTSSSAPTQASPAQAVPAQPVQTSAPEASTSYQQPTKTVKEEQATKTVADDQPADAQPGSAPQPTATNPSSNQSQQQKQQPRKGSKVEIPTEEFDFEQANAKFSKELEQERELEHAGYNKSSSFFDNISSSTDERTNMRWHEERNLNMDTFGEASLQRGRGRGRGRGGRGNWRGRGNYRGRGGNWRGGNSNRGRNSDYNTKPEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEH0</accession>
    <name>C4YEH0_CANAW</name>
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        <recommendedName>
            <fullName evidence="5 14">Histone acetyltransferase type B catalytic subunit</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="19" type="ORF">CAWG_00927</name>
    </gene>
    <organism evidence="19 20">
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        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the HAT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="4 14"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEH0"/>
    <dbReference type="SMR" id="C4YEH0"/>
    <dbReference type="PaxDb" id="5476-C4YEH0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00927"/>
    <dbReference type="HOGENOM" id="CLU_036024_2_1_1"/>
    <dbReference type="OMA" id="WTCDAND"/>
    <dbReference type="OrthoDB" id="10253098at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.390:FF:000005">
        <property type="entry name" value="Histone acetyltransferase type B catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000114">
        <property type="entry name" value="Histone acetyltransferase type B catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.360.10">
        <property type="entry name" value="Histone acetyl transferase 1 (HAT1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037113">
        <property type="entry name" value="Hat1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013523">
        <property type="entry name" value="Hist_AcTrfase_HAT1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21184">
        <property type="entry name" value="HAT1_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038084">
        <property type="entry name" value="HAT-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="18">
        <location>
            <begin position="19"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="16">
        <location>
            <begin position="51"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="16">
        <location>
            <begin position="209"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="15">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="234"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with histone H4 N-terminus" evidence="17">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR038084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEQ42706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="413" mass="48355" checksum="94B7ACA991EA8747" modified="2009-07-28" version="1">MSSAKEQSSVTAALQPEQWTTSSNEALKLFVTNPEAALNFQPTFTYPIFGDAETIYGYKDLDIFLCFDHYTFKPFLNIKYSAKLTDDPEIIDIKKTIDEFLPKSTIFKDEVKWVDSIKEEKDNGYKIPGKLIDSFSENDKEYDIYKIDLKSDNGYELHQRLQILVLLFIEAGSFIDAKDELWNLYVLYEKDNKSTSNNEPSIVGFTTAYNYWKYPGAKKFDSTEQESRIKISQFIILPIYQGQGLGQLFYSHLFDKWLAQDDIIEVVVEDPNESFDDLRDRADLKRLNTSEQFDFKAVTPKVDKEWVEKTRRALKLEKRQFARLLEIILLYKLKHGYPGITKRDVRLFIKKRLYDKNKEGLATLDDNTKKDKLQTAYQALEDDYYRILGDLKLNIKRENDEEETDTVSKKQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C4YET5</accession>
    <name>C4YET5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YET5"/>
    <dbReference type="PaxDb" id="5476-C4YET5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01043"/>
    <dbReference type="HOGENOM" id="CLU_1120035_0_0_1"/>
    <dbReference type="OMA" id="CEIKVND"/>
    <dbReference type="OrthoDB" id="4015512at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="254" mass="29597" checksum="271A1DC1FDEB1D20" modified="2009-07-28" version="1">MKKEKKLLVSSQHIPGDRQHHAHHHKRQPLSNITSARINKPTSTTKTNLLSTRKLLSKFEKPKREIFSNKSYEFEVLNNRGSNNKYTKIENEFDSKNIISKDLTINSFLKKFKEMVNWYKLNKFQFEITNTTSKEGVNNNGYFEQVNKNVITGQIMQNIVKRNYIRPEYSKAKITATHKVNQIGKLSEFMYAVKVSGETSNDDNQTQTEKTVLLMNVGNCEIKVNDRLNLNDLCYLMDYQGGKLGVYLRWHVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YET7</accession>
    <name>C4YET7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_01045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YET7"/>
    <dbReference type="ESTHER" id="canal-q5ai12">
        <property type="family name" value="abh_upf0017"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YET7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01045"/>
    <dbReference type="HOGENOM" id="CLU_032487_1_0_1"/>
    <dbReference type="OMA" id="GCCRTKI"/>
    <dbReference type="OrthoDB" id="5954035at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000770">
        <property type="entry name" value="Medium-chain fatty acid ethyl ester synthase/esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF44">
        <property type="entry name" value="MEDIUM-CHAIN FATTY ACID ETHYL ESTER SYNTHASE_ESTERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="149"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ42823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="425" mass="48089" checksum="D86A1258EFC53D62" modified="2009-07-28" version="1">MGILGWGFRSNIKIHQSDDEGSAALSLKDKGTIKFSQFIKQDLPILDESQKLWLNPLLFNGTLQTLYYTSMDSSNKFLIYYGRELFTYSDGGICSLDWVIPKPEDEQKFETIRKETLPEGFPRLQPRCRYFTNEELAELHQEDSTSEKPIVVIIHGLGGGSHESLIRDFAETIEKKTSGWGVVVINSRGCGRTKLTSGKLFNAGSTNDIREVLQDFKKRWPNRPIYLVGFSFGGALTANFLGEEGEKENSESLVKAACTVGCPWDFVDGAYHLQKSWTGKYLLSPALAKFLAKIVTNNYKELETYAPDIVNKETLKVIKNCKTLWEFDDNVTCKTTPYKDAFEYYQELSPVKKLSQIKTPLLALNSTDDPAVGVKLPISQMKANPYFCLVETDLGGHLGYVQSNGEFWCVELVEQFFQKFEELVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF74</accession>
    <name>C4YF74_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRP9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_01186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF74"/>
    <dbReference type="PaxDb" id="5476-C4YF74"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01186"/>
    <dbReference type="HOGENOM" id="CLU_104695_0_0_1"/>
    <dbReference type="OMA" id="EPNSGKC"/>
    <dbReference type="OrthoDB" id="5419752at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039914">
        <property type="entry name" value="SRP9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039432">
        <property type="entry name" value="SRP9_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834:SF12">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05486">
        <property type="entry name" value="SRP9-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP9" evidence="2">
        <location>
            <begin position="67"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ42960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="231" mass="26053" checksum="D192226A569D66A4" modified="2009-07-28" version="1">MQYHYVQCLFDSKTSSWGSYTIELCHTTSNINLCENRNGKKKFFSTIKNLLTKAIIYNNYLPIMPKVTSIEKFIELSTELLANYPTTTTLSTTYTNVSKKSKKSTSESAATSKPKSNKISTHAVSFKLYEPNSGKCIRYTTTKSKELSRLLNFIGPKGLTNDNLHVVGLASLMTNVKYEKPIEPSLENTPIPESENLATKEIEQNKPDAKEEKTTTTTSSKKKNKKKKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFH1</accession>
    <name>C4YFH1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_01289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFH1"/>
    <dbReference type="PaxDb" id="5476-C4YFH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01289"/>
    <dbReference type="HOGENOM" id="CLU_1106979_0_0_1"/>
    <dbReference type="OMA" id="SWPERIN"/>
    <dbReference type="OrthoDB" id="10361879at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="251" mass="29134" checksum="9FB111EE965C31C3" modified="2009-07-28" version="1">MATPTTPTTTTATTATIATTTTPSDLDVKELWKPLLDVIIRTIEDEQRYIIRDVCDYVPNLTIKNYQKKHLSYFHGLRSFFKGRDFDEVAKFIRLPQDPNEFPQESWPERINTLVFDVLSLTAPDFYYQFQDDKSGQVNLYNLMITTGYVVPEYLARNELNKLTYSPRMNFSRFQRKVTEVTSLARRSNYPVKDRDVVMTIIGNMHKSPSTVEIALTAYRLKKYESLSVFFVFLKKTREYGTSATVLSVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFJ3</accession>
    <name>C4YFJ3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CBK1 kinase activator protein MOB2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_01311</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Interacts with protein kinase CBK1 to form the RAM CBK1-MOB2 kinase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MOB1/phocein family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFJ3"/>
    <dbReference type="SMR" id="C4YFJ3"/>
    <dbReference type="PaxDb" id="5476-C4YFJ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01311"/>
    <dbReference type="HOGENOM" id="CLU_038321_2_1_1"/>
    <dbReference type="OMA" id="CNHSSER"/>
    <dbReference type="OrthoDB" id="10261121at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000920">
        <property type="term" value="P:septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.30:FF:000004">
        <property type="entry name" value="CBK1 kinase activator protein MOB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ43074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="313" mass="35384" checksum="8554555198B9AAA8" modified="2010-10-05" version="1">MSFLNTIRGLGRGSKKNKKDLEPSNNAIYSHSNLSGNGLRRTQSPTKFSPSKLSSKGAQGSAAYTSSPTKRSRTGQSLQHQDSQSSLQYQQQSGSVSPSKRSSIQTTKSTTVNADPPLFLCEPYVKTALVKGSFKTIVQLPKYVDYCEWLALNIFELFNHLNRFYGVIQEYATPEAYPTMNAGPNTNYLWVNSSGQAVNLPACQYIEYVITWVTNKLNDQSVFPTKNGGAFPPNFIKDCKNISRQMFRIFAHIYHNHFDKIIHLSLEAHWNSFFAHFISFVKEFNLIDRTEMEPLLPLIENFEQQGKITQASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFK5</accession>
    <name>C4YFK5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Lactoylglutathione lyase</fullName>
            <ecNumber evidence="3 9">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_01323</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-S-lactoylglutathione = methylglyoxal + glutathione</text>
            <dbReference type="Rhea" id="RHEA:19069"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:57474"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="4.4.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glyoxalase I family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="3 9"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFK5"/>
    <dbReference type="SMR" id="C4YFK5"/>
    <dbReference type="PaxDb" id="5476-C4YFK5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01323"/>
    <dbReference type="HOGENOM" id="CLU_046006_0_0_1"/>
    <dbReference type="OMA" id="MGDAWGH"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF30">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00935">
        <property type="entry name" value="GLYOXALASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="VOC" evidence="10">
        <location>
            <begin position="23"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="10">
        <location>
            <begin position="176"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ43086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="342" mass="39525" checksum="D6245817F05D52C3" modified="2010-10-05" version="1">MFKRFFSYTPRTFKMATFNNSFLMNHTCLRIKDPKVSIPFYTEKFGMKLIATFPFADFTLYMLNYETEANKHLNWSAREGVLELCHNHGVENDSNYKLNNGNGEKDRGFGHICMSVDNIEAFQDQLLKSEVKFQKKLSDGRQKNIAFALDPDGYWIELIENGINKVANKTEVSSYKLNHTMIRVKDPKKSLEFYRDVLGFKLLSTSEHEGAKFTLYFLGYDHDPNFKQDTLVRNEQAKREGVIELTHNWGTESDPEFKGYHNGNSTENGALQGFGHTCVSCEDPAKFCQELEEKFGDKLDWSLKWDQGKIKKIAFIRDPDGYSIEILGHDLFADSFKEQANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFM2</accession>
    <name>C4YFM2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_01340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the VPS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFM2"/>
    <dbReference type="PaxDb" id="5476-C4YFM2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01340"/>
    <dbReference type="HOGENOM" id="CLU_063749_0_0_1"/>
    <dbReference type="OMA" id="IHGHQCI"/>
    <dbReference type="OrthoDB" id="10258130at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07394">
        <property type="entry name" value="MPP_Vps29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000078">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000100">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028661">
        <property type="entry name" value="Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="39"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="261" mass="29040" checksum="43EC468FEBBD5CD5" modified="2009-07-28" version="1">MLTLAIGDLFVPERAVDLPSKFRKLLAPQPNNTPSNSKINQVICLGNITNSSTILQFLTNISPQFNLVKGEFDNPVVLSQQLSSLNKSSNIPLYNRFVHDNLKIGYTNGFQVIPRGDPLALSAFARELDVDVLIWGGTHKVEAYTLDGKFFINPGSATGAFNFDWPENDEEEQEEADKSQDDDEATDKESHDTEEAEPKVENETSTSASDDFKQTLHEVSEINSNIPSFCLLDTHGSTCILYIYTQIDGEVKVDKVTYTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFS4</accession>
    <name>C4YFS4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MEMO1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFS4"/>
    <dbReference type="SMR" id="C4YFS4"/>
    <dbReference type="PaxDb" id="5476-C4YFS4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00050"/>
    <dbReference type="HOGENOM" id="CLU_038085_0_0_1"/>
    <dbReference type="OMA" id="MHLPYIH"/>
    <dbReference type="OrthoDB" id="417112at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ41863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="37451" checksum="50C78494775BCAEA" modified="2010-10-05" version="1">MSIRPATHAGSWYSNNPTKLKNQLDQFFAKARSLKTPLSGEDASNGIDGARILIGPHAGYTYSGERLAESFNAWDTSKVKRVFLLGPSHHVYFKNHALLSPFEYYETPFGNIPVDVSTIKELLDEQCKHGPVFKYMSEEIDEEEHSFEMHAPFIYYKGETAIHGLPKIIPILISGMDGKLQEGIVNSLLPYLDNEENHFIISSDFCHWGSRFGYTKYLSSGETTLDTLSDNITSLGSLHRPKGLQIYKSIELLDKIALQIATNGSSAAWSKYIDISGNTICGQKPILIVLKLLEKYNNNSSSRGNTFNWIGYSQSNPVQRTSESSVSYASGYVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFU7</accession>
    <name>C4YFU7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_00073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFU7"/>
    <dbReference type="PaxDb" id="5476-C4YFU7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00073"/>
    <dbReference type="HOGENOM" id="CLU_109462_2_0_1"/>
    <dbReference type="OMA" id="CLGGFGK"/>
    <dbReference type="OrthoDB" id="411584at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044572">
        <property type="term" value="P:[4Fe-4S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230:SF7">
        <property type="entry name" value="BOLA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ41886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="121" mass="13756" checksum="68FAB6EF53544DAA" modified="2009-07-28" version="1">MLRSFIRRMSSAKPPQISHSETPGPIESSIISKITNEFKPLYFKIDNDSHKHAHHAGIRGAKNKTESHFRLEIVSDVFEGKSLPARHRLVYSLLANELKNDGVHALQMKTKTPEEINKTQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG06</accession>
    <name>C4YG06_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_00119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YG06"/>
    <dbReference type="PaxDb" id="5476-C4YG06"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00119"/>
    <dbReference type="HOGENOM" id="CLU_017277_0_0_1"/>
    <dbReference type="OMA" id="LIWINDW"/>
    <dbReference type="OrthoDB" id="410651at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000167">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="188"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ41930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="625" mass="72291" checksum="F72425552D53C01A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGE3</accession>
    <name>C4YGE3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="2">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_03119</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="2"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGE3"/>
    <dbReference type="PaxDb" id="5476-C4YGE3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03119"/>
    <dbReference type="HOGENOM" id="CLU_034315_2_1_1"/>
    <dbReference type="OMA" id="GPMTNPA"/>
    <dbReference type="OrthoDB" id="427800at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1030.10:FF:000002">
        <property type="entry name" value="Anthranilate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.10">
        <property type="entry name" value="Transferase, Pyrimidine Nucleoside Phosphorylase, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285:SF2">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycosyl transferase family 3 N-terminal" evidence="11">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 3" evidence="10">
        <location>
            <begin position="87"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ44825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="369" mass="39498" checksum="EF4DFF776EDAE430" modified="2010-10-05" version="1">MTTSSKNALTPYLKKLVVEPPTLEPKDLSEALELIFSDIPSDIQTAAFLSCLRLRGLDQEADYIAAAVTTVLHFAKTIPPELVDSKGYIDIVGTGGDGQNTFNVSTSSAIVAAGMGLPVCKHGGKASTSSSGSGDLLKSLGVDLSHVNEVTTPEIVKKSKFCFLFAPSFHPGMGLVAHIRSQLGVPTIFNILGPLINPIPLRARVLGVYSEKLGESYAQAASILAKKNETHEKTMVVFGEVVLDEISPIGYTKTWTIDKSGKIERNRISPKDFGLPEHDLSTVKSGTPQQNAEILSHILNQDNDEFKVKQDSNNHPLVDYILMNSAAVAVVSGIADNWVDGVALAKESIVSGAAKKALEDFQNSSKEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGW8</accession>
    <name>C4YGW8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_03306</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YGW8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03306"/>
    <dbReference type="HOGENOM" id="CLU_003142_0_0_1"/>
    <dbReference type="OMA" id="HWLQEWT"/>
    <dbReference type="OrthoDB" id="20828at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019035">
        <property type="entry name" value="Mediator_Med12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med12" evidence="9">
        <location>
            <begin position="183"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="43"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="390"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="575"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1552"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="584"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1566"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1576"/>
            <end position="1602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ45000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1747" mass="199980" checksum="136D66FD000A8950" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGX0</accession>
    <name>C4YGX0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetylornithine aminotransferase, mitochondrial</fullName>
            <ecNumber evidence="5">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_03308</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="5"/>
    <dbReference type="EMBL" id="CH672349">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGX0"/>
    <dbReference type="PaxDb" id="5476-C4YGX0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03308"/>
    <dbReference type="HOGENOM" id="CLU_016922_10_1_1"/>
    <dbReference type="OMA" id="MVPGFKY"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002325">
        <property type="entry name" value="PRK01278.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="10 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ45002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="455" mass="50207" checksum="22A149A2E47C4536" modified="2009-07-28" version="1">MLRTYSKSLLKTSTTIKKSFSFNTATLSLPTNKKYSTSVPDANDESHTGKFINSISKPYSVTTYARPNLVLTHGKGSYIYDLEDRKYIDFTSGIAVTCLGHSYEPITQLIKDQSEKLIHCSNLYYNLPAGELSNKLIVKTKEFDGMKDASRVFLCNSGTEANEAALKFARKYGKSINPEKYEFITFENSFHGRSMGALSVTPNPKYQEPFSPLIPGVKIAKPNDIESVKQVINKDKTCAVIIEPLQGEGGVNIIDESFLIELRKLCDENNVLLIYDEIQCGLGRTGKLWAHSWLSPEAHPDIVTIAKALGNGFPIGATMITEKVEKSLNVGDHGTTYGGNPLASTVGSYIVDHIGDKEFLQQVENKSQIFLEGLNKIAEENPNLIEKVKGKGLLLGLQFKKNVDIGEIVAKCRQHGLLIITAGMNTIRLVPALNIPDQTIKDGLEILTQSIKEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHB2</accession>
    <name>C4YHB2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHB2"/>
    <dbReference type="PaxDb" id="5476-C4YHB2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03458"/>
    <dbReference type="HOGENOM" id="CLU_1467956_0_0_1"/>
    <dbReference type="OrthoDB" id="4027943at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946484" evidence="1">
        <location>
            <begin position="19"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="183" mass="19403" checksum="82EA774747D87F45" modified="2009-07-28" version="1">MKFSKVASIAILALSAQAAIVQSNQEPTKAKKDVIARDVDGAVGVNVLSKRENNYDALVKNDELSSILPILISAISAALPEIIKIVSGLLGDSSTASSTGSLNEQDVIGDIVDEVKKVLPQAISSVQQNAGNTKRDTTTELIQAIIQEGVKLTPEIISFLQKITPQVIEVLTKEAPQLLQGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHP7</accession>
    <name>C4YHP7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_03596</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHP7"/>
    <dbReference type="PaxDb" id="5476-C4YHP7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03596"/>
    <dbReference type="HOGENOM" id="CLU_069856_0_1_1"/>
    <dbReference type="OMA" id="FYENYNT"/>
    <dbReference type="OrthoDB" id="5512at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF7">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="56"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="107"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ45279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="224" mass="25852" checksum="D5FAA3C73E351987" modified="2009-07-28" version="1">MADKFPEIDTPAAGGNDDYEGDFLSREKELVGDEFTTDQDKQVFQDDEDEEINEFKEQFPEVDTKAQPSGISVTKSADKDDDDDEFEGFESSNGAAKELNLSESQAIKEWKQRRDLEIEEREKLNSKKKEEIIEKAKSTIDDFYENYNSKRDNHQKEILSEQEKFISKRDDFLKRGTLWDRVNELVTEVGELPGDESRDKTRFKELLTKLKGKENVPGAGGYQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHS2</accession>
    <name>C4YHS2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Survival protein SurE-like phosphatase/nucleotidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHS2"/>
    <dbReference type="PaxDb" id="5476-C4YHS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03621"/>
    <dbReference type="HOGENOM" id="CLU_007204_0_0_1"/>
    <dbReference type="OMA" id="TNTCFQE"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027746">
        <property type="entry name" value="TTL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="706" mass="80606" checksum="38074C4E2BC13BFC" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHS4</accession>
    <name>C4YHS4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_03623</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NHP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHS4"/>
    <dbReference type="SMR" id="C4YHS4"/>
    <dbReference type="PaxDb" id="5476-C4YHS4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03623"/>
    <dbReference type="HOGENOM" id="CLU_082854_10_3_1"/>
    <dbReference type="OMA" id="MKNMGGK"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01390">
        <property type="entry name" value="HMG-box_NHP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000016">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="10">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="8">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ45306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="92" mass="10509" checksum="DB27DD3566B5D6F6" modified="2009-07-28" version="1">MAPGERKKSSRKKKDPDAPKRSLSAYMFFANENRDIVRAENPGISFGQVGKLLGEKWKALNSEDKLPYENKAEADKKRYEKEKAEYAKKNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHV3</accession>
    <name>C4YHV3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SURP motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_03656</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHV3"/>
    <dbReference type="PaxDb" id="5476-C4YHV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03656"/>
    <dbReference type="HOGENOM" id="CLU_013259_0_1_1"/>
    <dbReference type="OMA" id="HYASIDW"/>
    <dbReference type="OrthoDB" id="447637at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045146">
        <property type="entry name" value="SF3A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022030">
        <property type="entry name" value="SF3A1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316">
        <property type="entry name" value="SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316:SF1">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12230">
        <property type="entry name" value="PRP21_like_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="18"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="110"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="298"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ45335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="425" mass="48956" checksum="D4D10BF13AEAA596" modified="2009-07-28" version="1">MTSIPSDIKLPPSDVKQTIDKTVGYVIKNGKSFEERLLKNNKNDKFTFIKPDNEYFPYYKWKLDTSKKNQGSTETSTENQHQEEDIIIAKPPDLPFLIDLPIISQHDLDVIKITALYIAQNGESKIPKLLQHETKLNNRAQFEFLNESHSLHGLFQKYIQQYKIVIELYQNSHGENVDQDQEYLQLRQLIKKPRGEYDILTQAYNRAQYIKQNKVIAKREQEESKARQLHYASIDWQDFSIVAKVDFNAIDAVKELSMPLKRDDLIKRSLDARSKDIELPKVAVAATTTSPVQVEVIDTKNQGSTQDQTDNNTSTPSSPPIKGMKIKAAGTSRLKKSSEANTSTTTTNTIKCPITGKLIPENEFDTHIKTLLRDPRYKKEQENYIRKNFSYASNITTDQVYENIKRFVKKRANVEDENPKKKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHY1</accession>
    <name>C4YHY1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_03685</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHY1"/>
    <dbReference type="PaxDb" id="5476-C4YHY1"/>
    <dbReference type="HOGENOM" id="CLU_004483_1_0_1"/>
    <dbReference type="OMA" id="HITRTIM"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000222">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="621"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="204"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="370"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ45363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="857" mass="98003" checksum="61C48CB5C62E0333" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHZ3</accession>
    <name>C4YHZ3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_03699</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
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        <property type="protein sequence ID" value="EEQ45375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="SMR" id="C4YHZ3"/>
    <dbReference type="PaxDb" id="5476-C4YHZ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03699"/>
    <dbReference type="HOGENOM" id="CLU_015166_3_2_1"/>
    <dbReference type="OMA" id="FFGVYEF"/>
    <dbReference type="OrthoDB" id="415315at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000095">
        <property type="entry name" value="Mitochondrial carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="139"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="245"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <end position="11"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ45375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="366" mass="40643" checksum="362B7B7C78BC6447" modified="2010-10-05" version="1">MSQVFTSSTIPLTFESREHKEHHSIRNKPPSSPPESTDNETLQQPIWQCMLAGGFGGVVGDSAMHSLDTVKTRQQGFPYKVKYKHMIPAYSTILKEEGFFRGLYGGYTPAALGSFPSTAAFFGTYEYSKRVMINQWHVNETLAYFIAGILGDLASSIFYVPSEVLKTRLQLQGKYNNPYTKECGYNYRGLGNAIVTIAKTEGPKTFVFGYKETLFRDLPFSALQFSFYETFRQWAIYSNNGSDDLSISMELLTGAAAGGLAGTLTTPLDVIKTRIQTATNTSELSSSISTKQTITNPIIRLLNRNATLKALVSIYKHEGILGAFSGVGPRFIWTGIQSSIMLLLYQVALKQLDVLSDDKDRDKLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI56</accession>
    <name>C4YI56_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI56"/>
    <dbReference type="PaxDb" id="5476-C4YI56"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03764"/>
    <dbReference type="HOGENOM" id="CLU_855293_0_0_1"/>
    <dbReference type="OMA" id="ICILYCI"/>
    <dbReference type="OrthoDB" id="4073891at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="35159" checksum="6464A1D416AC0401" modified="2009-07-28" version="1">MNKEEIYTIRPTRSKLLIVWSILELCTVSLLFAMSFFFLFANSKLIQRGSPAFQLRIQSDSIFAKNTFQLVQQGLKFATYLSNDLNIYINETIPETYLQQIDSNYDNNLYQFNVFGFCRKTQFDKILNCYNGQGINIAACFLQDIGTHLGNLTNQADPNNVSTKLVSFYYNLVDQICSDSDKKLCALQTYNTMSRIVQYLGISSLICLAVTTSTSFFEMIGYCVFAKSLTRVFFIFKVISMLVFVFTICILYCIIMVMKNFLTDLITQFQIGTLEFPSIKWITWGVLTLMCLIIVVKRYLIYQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI82</accession>
    <name>C4YI82_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_04154</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI82"/>
    <dbReference type="SMR" id="C4YI82"/>
    <dbReference type="PaxDb" id="5476-C4YI82"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04154"/>
    <dbReference type="HOGENOM" id="CLU_140672_0_0_1"/>
    <dbReference type="OMA" id="NKGHKTE"/>
    <dbReference type="OrthoDB" id="9616667at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000003">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01190">
        <property type="entry name" value="RIBOSOMAL_L36E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ45817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="99" mass="11067" checksum="CFE16D476375F6F7" modified="2009-07-28" version="1">MAKSGIAAGVNKGRKTTAKEVAPKISYRKGASSQRTVFVRSIVKEVAGLAPYERRLIELIRNAGEKRAKKLAKKRLGTHKRALRKVEEMTQVIAESRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YID3</accession>
    <name>C4YID3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TATA-binding protein-associated factor mot1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Modifier of transcription 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_04206</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YID3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04206"/>
    <dbReference type="HOGENOM" id="CLU_000315_1_2_1"/>
    <dbReference type="OMA" id="WYSDIAC"/>
    <dbReference type="OrthoDB" id="10252227at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17999">
        <property type="entry name" value="DEXHc_Mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000009">
        <property type="entry name" value="B-TFIID TATA-box-binding protein-associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000428">
        <property type="entry name" value="TATA-binding protein-associated factor 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044972">
        <property type="entry name" value="Mot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044078">
        <property type="entry name" value="Mot1_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022707">
        <property type="entry name" value="Mot1_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498:SF1">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12054">
        <property type="entry name" value="DUF3535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="1314"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="1676"/>
            <end position="1827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="178"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1845"/>
            <end position="1880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1850"/>
            <end position="1859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ45868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1917" mass="214132" checksum="81C89039441014A3" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIJ9</accession>
    <name>C4YIJ9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
            <location evidence="1 4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RPF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIJ9"/>
    <dbReference type="PaxDb" id="5476-C4YIJ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04275"/>
    <dbReference type="HOGENOM" id="CLU_049783_0_0_1"/>
    <dbReference type="OMA" id="VGLKPMF"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="28"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="293"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ45934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="327" mass="37945" checksum="A7D5EC5C711C890C" modified="2009-07-28" version="1">MIRTIKPKNARSKRALAKKEAKLVENTKSALFVPGSTGNKFLHDAMCDLMAFKKPFAKKFSKKNEIRPFEDSSQLEFFAEKNDSSLMVFSSNNKKRPKTLTFVRFFNFKVYDMIELSIQENHKLLQDFKKLTFTIGLKPMFVFNGPIFDSHPVYQHIKSLFLDFFRGEETDLQDVAGLQYVIALSAGEVEDLNNDKVLPLVHFRVYKLKSYKSGQKLPRIELDEIGPRFDFKIGRRITPTPDVEKEATKKPKQLEAKVKKNVTTDFMGDKVAQIHVGKQDLSKLQTRKMKGLKEKYDQESEEEDVYVSDEEYFGEDIEEPETKRQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIP5</accession>
    <name>C4YIP5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_04321</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NOP53 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIP5"/>
    <dbReference type="SMR" id="C4YIP5"/>
    <dbReference type="PaxDb" id="5476-C4YIP5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04321"/>
    <dbReference type="HOGENOM" id="CLU_035888_1_1_1"/>
    <dbReference type="OMA" id="TEKWTHK"/>
    <dbReference type="OrthoDB" id="5072at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017302">
        <property type="entry name" value="Gltscr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="240"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="292"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ45980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="416" mass="48542" checksum="62B224A8DD5ABFE2" modified="2010-10-05" version="1">MSEEIISKKPSKPQASRKGKRAWRKNIDIQEIEQNLQDKRDEEIVLGKEVTDDFVIDDTPSSKSGKLPKKLKTKEILTNKSKIPALTNQRHQKKGENTIQGVKKTDLLRLIQLNGGKFKSEDKYVNRLEQDGIVNGSSQDLWDDTDNNEKKKIPDFMKSTAEVTKASVVPKTLKVNPIKITSNELTDKKIHAGKSYNPSLESWKELINQEYDIEYKRELTRQQIEEHRNKIKELMITLDDNMLSDSDDDEDDEDNDKVEEEEQLNANGEKDYSLSINKPNKIKIKTKTKRNKELKHKERVKLEQEIKDLKKQLKDLSNLDEILEKQAVKDQSQPNEKKRKRREKLFKYSLVETPLEVKLSDELSGNLKNLKPEGNLYYDQMLSLQSSGKIESRVPVNKKRKYTKKITEKWTYKDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIW6</accession>
    <name>C4YIW6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_04395</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ46051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIW6"/>
    <dbReference type="PaxDb" id="5476-C4YIW6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04395"/>
    <dbReference type="HOGENOM" id="CLU_001265_46_12_1"/>
    <dbReference type="OMA" id="RGPIFIL"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001406">
        <property type="term" value="F:glycerophosphodiester transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17364">
        <property type="entry name" value="MFS_PhT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="50"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="487"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ46051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="519" mass="57177" checksum="245915C246109D9B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ71</accession>
    <name>C4YJ71_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-directed RNA polymerase I 49 kDa polypeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_03884</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ71"/>
    <dbReference type="SMR" id="C4YJ71"/>
    <dbReference type="PaxDb" id="5476-C4YJ71"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03884"/>
    <dbReference type="HOGENOM" id="CLU_034953_2_0_1"/>
    <dbReference type="OMA" id="DVYPFDE"/>
    <dbReference type="OrthoDB" id="532500at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009668">
        <property type="entry name" value="RNA_pol-assoc_fac_A49-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14440">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06870">
        <property type="entry name" value="RNA_pol_I_A49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ45555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="393" mass="44273" checksum="9323BD8F9E4231DB" modified="2010-10-05" version="1">MSSSIKVNSVTEKPVATVGSFFNGLRVSPEVEFDLYKHKKRDDYVLHGETDTLDYNGTSNNENEYVVAVFDPNSKSVELYKTPYISTKVTAKKNRVYKGPKVKSAGIRNVTQRNALGEAFGTKKAKSAITNLEKNRIDSEKLQDIEMDIVDTVKESTRDLPAQEDGVDRPAPLANVDATNVEDIYPLENIIPEKDWQYLRVSSILTAENPLEKLPFTKSEFIAKQLPILISQKNTEKLQMLFYASLLLGVYENRRVKDKQSLMTRLQNIPSEILVDGILDRFAISRATKFGKSKDKSFTIDPYHEDKLLTYLFILLLHINNFTVELVPLSKDLKLKNTRLVGLFRALGAIIKSATVGEAEALGIPKSAVGTYKIATLKVPFKLPELTRRGKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ92</accession>
    <name>C4YJ92_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_03905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ92"/>
    <dbReference type="PaxDb" id="5476-C4YJ92"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03905"/>
    <dbReference type="HOGENOM" id="CLU_042989_0_0_1"/>
    <dbReference type="OMA" id="ANKRTIT"/>
    <dbReference type="OrthoDB" id="1093at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="217"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ45576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="418" mass="48833" checksum="74C95A6BAF3D8C9D" modified="2009-07-28" version="1">MDIDTEVSTVLATIRSESDNSELNNIIYQLEDFYERKLWHQLTQVLDQIYYPIDPTNTTTSSLIITSNLKNRLYNLFIKQFQLKLNPIKVVDYLLESFENDPKETLSTLLTLKKDFINDLKRSHNYRVTDDDDDDNEEEEEENQDEELKQLIQDDEAVIYVKLQIARYYLKLHQLNKAEDILIDVAPKFESLNNNLNSKINSAYYLEKTEHAKILNNYNDYYSNGLLYLSSVTNLTDEEKNKLRYELCIAALLGDKIYNFGELILHDIFQEISQPSSSTTSSQYNWLYQLIINLNAGNVDNFNHWLSIAIKKAPILEQHQIFLKEKLTIMALLELVSADKKLSFDIISEKTNTPIDQVELIIIKTMSLHLIEGYINQDQQYVVVSWIQPRILNLDQVKNLIQNVEHLSKNISLVCKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJA2</accession>
    <name>C4YJA2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_03915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJA2"/>
    <dbReference type="PaxDb" id="5476-C4YJA2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03915"/>
    <dbReference type="HOGENOM" id="CLU_538594_0_0_1"/>
    <dbReference type="OMA" id="LSHENNH"/>
    <dbReference type="OrthoDB" id="10267903at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="144"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <begin position="355"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ45586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="538" mass="61660" checksum="3DD5DD77C8CA6B64" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJK2</accession>
    <name>C4YJK2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation-transporting ATPase</fullName>
            <ecNumber evidence="13">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_04017</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="13"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YJK2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04017"/>
    <dbReference type="HOGENOM" id="CLU_001828_1_1_1"/>
    <dbReference type="OMA" id="FSCFQYM"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022890">
        <property type="term" value="F:inorganic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098662">
        <property type="term" value="P:inorganic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07542">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000032">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000119">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000068">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047821">
        <property type="entry name" value="P5B-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="422"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="618"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="647"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1109"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1139"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1177"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1222"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1252"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1292"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="248"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="384"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="15">
        <location>
            <begin position="480"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ45686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1350" mass="154124" checksum="504E6E49EE130C3A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJN7</accession>
    <name>C4YJN7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit BET3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_04055</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJN7"/>
    <dbReference type="PaxDb" id="5476-C4YJN7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04055"/>
    <dbReference type="HOGENOM" id="CLU_087110_0_0_1"/>
    <dbReference type="OMA" id="MVQMQVQ"/>
    <dbReference type="OrthoDB" id="10262857at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000001">
        <property type="entry name" value="Trafficking protein particle complex subunit BET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ45721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="191" mass="21780" checksum="99B1F489CEEA8CF6" modified="2009-07-28" version="1">MSKKTTGDDIWKNNVEKINSELFTLTYGSVVAQLCRDFQNNYIEVNNQLDKMGYNIGLRLIEEFLAKTGIRRCQTFKETAEVISKLGFRIFLNIQPTVENWSNDGKSCSLIIPEPNPLTEFVELPITADSKIAKELWYSQILCGVLRGALQMVQLDCDVSFVKDVLRGDDRTEIRLKLNRILKDEVPAGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJP9</accession>
    <name>C4YJP9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TSR3</name>
        <name evidence="10" type="ORF">CAWG_04067</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63300"/>
            <dbReference type="Rhea" id="RHEA-COMP:13852"/>
            <dbReference type="Rhea" id="RHEA-COMP:16309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJP9"/>
    <dbReference type="PaxDb" id="5476-C4YJP9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04067"/>
    <dbReference type="HOGENOM" id="CLU_035060_0_0_1"/>
    <dbReference type="OMA" id="HHIRKGR"/>
    <dbReference type="OrthoDB" id="10262062at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002621">
        <property type="entry name" value="PRK02287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase L inhibitor RLI-like possible metal-binding" evidence="9">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="8">
        <location>
            <begin position="89"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="299"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ45733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="346" mass="39057" checksum="ED3B88403649495B" modified="2009-07-28" version="1">MAKGKNKTNDERPSKSRTSNGHKSKQHHIRKGRQEISASSTTSKSSTSFPAKLAMWDFDHCDPKRCSGKKLERLGLIKNLRVGQKFQGIVVSPNGKSIVCPNDKEIVETNGAAVVECSWARLDEIPFNKIGGKNERLLPYLVAANPVNYGRPWRLNCVEALAACFAIVRHTDWAELLLSNFSWGLTFLKINEELIELYQQCTDSESITKAQEQWLEKIEQEAKERKNQAHNEDVWMMGNVNRQEDNTEHDSDSNEEDAVDSESDIEYDNLGNIIQKKKYDSLGNEMIESKVKYDSLGNIISGEEGSSEEDNDEVSTNKEDNNTVYDNLGNVVTNESITKHRNSLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJS5</accession>
    <name>C4YJS5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoporin NSP1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Nuclear pore protein NSP1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoskeletal-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_04095</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nucleoporin NSP1/NUP62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJS5"/>
    <dbReference type="PaxDb" id="5476-C4YJS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04095"/>
    <dbReference type="HOGENOM" id="CLU_020542_0_0_1"/>
    <dbReference type="OMA" id="EMMSKQV"/>
    <dbReference type="OrthoDB" id="344345at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000040">
        <property type="entry name" value="Nuclear pore glycoprotein p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026010">
        <property type="entry name" value="NSP1/NUP62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007758">
        <property type="entry name" value="Nucleoporin_NSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084:SF0">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05064">
        <property type="entry name" value="Nsp1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin NSP1-like C-terminal" evidence="16">
        <location>
            <begin position="451"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="122"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="575"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="528"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="52"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="584"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ45759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="718" mass="74617" checksum="D950D3861D9B97A9" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJZ8</accession>
    <name>C4YJZ8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJZ8"/>
    <dbReference type="PaxDb" id="5476-C4YJZ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05790"/>
    <dbReference type="HOGENOM" id="CLU_069447_1_0_1"/>
    <dbReference type="OMA" id="DYIFREN"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053020">
        <property type="entry name" value="Smr_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417:SF1">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="99"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ47227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="241" mass="27325" checksum="813E68291C065C5E" modified="2009-07-28" version="1">MTEVFNRGAKLFDDNNQRDYNHATDSEYKRLRSEADRLFQKRQQLSQQSQNAYKQGDGQKAHELSEESKRILAQAEECNRKAAEYVFRENNEDSGPDEIDLHGLYVKEAEWILERRIYYAVKTNQSHLNVIVGKGLHSANGVAKIKPAVDELCDQVGLNHYIDKKNSGVLVIDLKGVNLDRLPSSWAQGTNNVAPPQQAYHGTGQPQYQQQQHQGDQQDIKTGNDLVDMVLKIVCGCLKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK11</accession>
    <name>C4YK11_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK11"/>
    <dbReference type="SMR" id="C4YK11"/>
    <dbReference type="PaxDb" id="5476-C4YK11"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05805"/>
    <dbReference type="HOGENOM" id="CLU_105491_0_0_1"/>
    <dbReference type="OMA" id="FESETGP"/>
    <dbReference type="OrthoDB" id="2536440at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42115">
        <property type="entry name" value="BETA-SYNTHASE (BETA-THIONASE), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42115:SF1">
        <property type="entry name" value="BETA-SYNTHASE (BETA-THIONASE), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="1">
        <location>
            <begin position="27"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="1">
        <location>
            <begin position="129"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="179" mass="20508" checksum="E42ECC500C73612B" modified="2010-10-05" version="1">MSETPLLFQTRDYRGATIEDLNIPLAVSINPTTSIYEAIGIAFENEFTYLPVIHERTKRLLGVINIEELKSNGDKLKRSILAPIVKSYMIWFNQSAKRKYEQENKEVLSSNRTAPKTTILKPRGKRYEVLTPMTPLEKLAEFFNSGNYFAIVTNGHGDFVYGVVTPQDLMKYEQSRPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK38</accession>
    <name>C4YK38_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription activator GCR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK38"/>
    <dbReference type="PaxDb" id="5476-C4YK38"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05833"/>
    <dbReference type="HOGENOM" id="CLU_069644_0_0_1"/>
    <dbReference type="OMA" id="LTWLMNG"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060963">
        <property type="term" value="P:positive regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052146">
        <property type="entry name" value="HOT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022210">
        <property type="entry name" value="TF_GCR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37784:SF2">
        <property type="entry name" value="HIGH-OSMOLARITY-INDUCED TRANSCRIPTION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37784">
        <property type="entry name" value="PROTEIN MSN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12550">
        <property type="entry name" value="GCR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription activator GCR1-like" evidence="2">
        <location>
            <begin position="243"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ47267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="343" mass="39533" checksum="128EFF4713A167B2" modified="2009-07-28" version="1">MDTDTIAYFDSKLDKVTSQLNIDNDKIVDLQQEIVLLKQYIDYQNSKIEKVTSLIGNLLEKKSQDEAVLNTIQALQEDVDVGDLQRQVDQLTSHHSLGQSQQQQQHQLLNSQHRQQPRQPNEQQSLQHHQQPHQQHQQQHLHQHQNQHQQQHSQRPSHMSQDISTQLESNMDPALHQVAVATAAVQQAQAHSQSNEPLGMASSSQQRVSKPTKKQSRKKSDITGSKGETAGAKSSPVRKVHITFMHNPTNVREIYDEFFKGYKGQEPLCELDEKYGKSEWRGDSRSKESKRFQRRKKLCDAIQRGMVKYGKNADEIIEYLESFRKDKSLTWLMNGHLPEDLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKB9</accession>
    <name>C4YKB9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_05917</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM22 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKB9"/>
    <dbReference type="PaxDb" id="5476-C4YKB9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05917"/>
    <dbReference type="HOGENOM" id="CLU_091077_1_0_1"/>
    <dbReference type="OMA" id="VNPNMAD"/>
    <dbReference type="OrthoDB" id="75343at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ47348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="184" mass="19608" checksum="E23230208452C70B" modified="2010-10-05" version="1">MSLWGVYTGPQPPKKPLQEMTQEEQAEEGARQMIGFMNSCPGKTVMAGVSGFALGGFFGLFMASMAYDTPIGTDAVKHISELPFKQQMKLQFTDMAKRSYSSAKNFGYIGMVYSGVECTIESLRAKHDIYNGVSAGCITGAGLAIKAGPQAALVGCAGFAAFSLAIDMYLNSDAAPPPKNDYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKD6</accession>
    <name>C4YKD6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_05938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKD6"/>
    <dbReference type="PaxDb" id="5476-C4YKD6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05938"/>
    <dbReference type="HOGENOM" id="CLU_074406_0_0_1"/>
    <dbReference type="OMA" id="PCDIVRS"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF94">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="1">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="1">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="1">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="1">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ47365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="40855" checksum="3524B5FD20269B0C" modified="2009-07-28" version="1">MEESNDYPSCSLQNSFISTLDHLPCDIVRSLWLIQSCNLKIDKYKQELNELLEKYATTTTTLTNEESYFLKRIVELKKRIEYLSRETIQESRSMNNQLITHKLNLLEEMNQLKKIEISKHNLIDDIEMKELRQQLKTHYNEHPLVSQMEAVQEQKDLMISSNDKSQTNDKNGGSSDSSSNTNGILKNKIKDEPEKSKLKLILRIPKQDKVIKPKNKKIVKKVQKKPTKRNTVISKDDKKSKTLRKKVPQLIELKEEPEKEEEQEDTTLYCFCKQPSFGNMISCDNESSCPNGEWFHYKCVGILNRVVALKYTTGKESWYCSENCKSMALQAKQSKKQKNGKRRKRRSHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKG4</accession>
    <name>C4YKG4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Multifunctional methyltransferase subunit trm112</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eRF1 methyltransferase subunit trm112</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_05967</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRM112 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKG4"/>
    <dbReference type="PaxDb" id="5476-C4YKG4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05967"/>
    <dbReference type="HOGENOM" id="CLU_086140_0_0_1"/>
    <dbReference type="OMA" id="NMLTSKC"/>
    <dbReference type="OrthoDB" id="2187549at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21089">
        <property type="entry name" value="Trm112-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000021">
        <property type="entry name" value="Multifunctional methyltransferase subunit trm112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039127">
        <property type="entry name" value="Trm112"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773:SF0">
        <property type="entry name" value="MULTIFUNCTIONAL METHYLTRANSFERASE SUBUNIT TRM112-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773">
        <property type="entry name" value="UPF0315 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158997">
        <property type="entry name" value="Trm112p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00083044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ47393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="130" mass="15033" checksum="3273F9C8FB87C380" modified="2009-07-28" version="1">MKFLTTNFVKCAVKSCQSSLDSFPLKYEECQLVQEEQDYNPEFIVHMLDRLDWNAIIQVAKDLGNESLPPNKPEDLDPIMEDNQAILKDLHTLLVETQIIEGKMICKNCQHIYYIKNSIPNFLLPPHLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKM3</accession>
    <name>C4YKM3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_06029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKM3"/>
    <dbReference type="PaxDb" id="5476-C4YKM3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06029"/>
    <dbReference type="HOGENOM" id="CLU_028981_1_0_1"/>
    <dbReference type="OMA" id="SEENWKD"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="302"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="711"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="711"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ47452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="747" mass="86599" checksum="899A80C45B38192D" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKQ5</accession>
    <name>C4YKQ5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DUS-like FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_06061</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKQ5"/>
    <dbReference type="PaxDb" id="5476-C4YKQ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06061"/>
    <dbReference type="HOGENOM" id="CLU_013299_3_2_1"/>
    <dbReference type="OMA" id="DESYTMT"/>
    <dbReference type="OrthoDB" id="10262250at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052582">
        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="11">
        <location>
            <begin position="11"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="386"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ47484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="433" mass="49250" checksum="409B745AEDB0D264" modified="2009-07-28" version="1">MIEYANKLCLAPMVRSGELPIRLLSLRYGCDLLWTPELVDKKILQSTRIINQELNTIDYIVSNHQQSDKKTVIFRKHPDETGRLILQLGSSDPQLAVDAARKVIDDVDGIDLNCGCPKNFSTHSGMGAELLKTPDKLCSILINLVEKIGIPNKKSISCKIRLFNNYDQSKNLIEKILQTGISNLTIHCRTPIMRNRQDPVWNFLPKLIPIIQTAGVNLVINGNMQNVADLKNLQSALNDNGGGKLSIMIAEAAEANPSVFSHSPKPQCLIIQELFEICQKYYQNFSATKFLMLNMIPGKSKYFQKLSQTKSFDQMGVILKEISQEYEKQKQMSTKGLDKIFTIMNRDCQKANFFNLDQFQKHIAQRGEYMTKFFHEWQESTMLEDFDDTPTKRPLSNDNNNNVSNQPSKRQKKKMAKSQTQPSSSIENPIKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKS2</accession>
    <name>C4YKS2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial 15S rRNA processing factor CCM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_06080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKS2"/>
    <dbReference type="PaxDb" id="5476-C4YKS2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06080"/>
    <dbReference type="HOGENOM" id="CLU_015498_0_0_1"/>
    <dbReference type="OMA" id="THLIMEL"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14596">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14596:SF72">
        <property type="entry name" value="ZINC FINGER PROTEIN MSN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="4">
        <location>
            <begin position="907"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="646"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ47501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="993" mass="114492" checksum="972D80AD400D00FC" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKV4</accession>
    <name>C4YKV4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CAWG_06113</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Preautophagosomal structure membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKV4"/>
    <dbReference type="PaxDb" id="5476-C4YKV4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06113"/>
    <dbReference type="HOGENOM" id="CLU_047751_0_0_1"/>
    <dbReference type="OMA" id="NKGNAID"/>
    <dbReference type="OrthoDB" id="29460at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.130.10:FF:000050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018939">
        <property type="entry name" value="Autophagy-rel_prot_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF13">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09451">
        <property type="entry name" value="ATG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-0732">Signal</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013039573" description="Autophagy-related protein 27" evidence="19">
        <location>
            <begin position="16"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="20">
        <location>
            <begin position="16"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EEQ47533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="252" mass="28308" checksum="092D9CD0E1FF5562" modified="2009-07-28" version="1">MILASLLTFATAALAFDCSDKELERYNFESIKGVHSYTTLKNTPPSQTNVTWNVGICQPISAIKDCPANSDICGVTSILRKDEKPVVSEVVSFKSDLQKTYESSDNGIKVIYKGANWGDVLVNAELNFQCDKDSQNNEFTLDQWDGTNLKLSMKTKAACITSKEDKKKEKHDNGESWGWFTWIFIFLVLFLSIYIIGGAWFQYNKGNAIDFQSALKEVVENFIELLKGLPSFGKEIIEKFTGRSNRGEYSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKZ1</accession>
    <name>C4YKZ1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 12">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_01504</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 12"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKZ1"/>
    <dbReference type="PaxDb" id="5476-C4YKZ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01504"/>
    <dbReference type="HOGENOM" id="CLU_014892_2_1_1"/>
    <dbReference type="OMA" id="CEVLYIC"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990467">
        <property type="term" value="C:NuA3a histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="14">
        <location>
            <begin position="240"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="697"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="697"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="735"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="761"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="785"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ43272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="799" mass="92031" checksum="7247B58CE59BDF41" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL59</accession>
    <name>C4YL59_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_01574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OMA" id="QILDKWF"/>
    <dbReference type="OrthoDB" id="10264848at2759"/>
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        <property type="component" value="Chromosome R"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF02204">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ43340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="793" mass="90298" checksum="3285B030A6F5382D" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL71</accession>
    <name>C4YL71_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_01586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL71"/>
    <dbReference type="PaxDb" id="5476-C4YL71"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01586"/>
    <dbReference type="HOGENOM" id="CLU_2170711_0_0_1"/>
    <dbReference type="OMA" id="AINMIRL"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="117" mass="13211" checksum="8D47CC34BDBD5779" modified="2009-07-28" version="1">MHIFIAPIQSETGSKSLTNQQPSSSKEQSYSLHYCIEVQNQLENLLNYIPEKLLAKAVAHTNSTSAINMIRLIFTSGAYKERQIYYTKASHKIKPNGSGRNRGSQLQDEIAIWLLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLE6</accession>
    <name>C4YLE6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_01664</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLE6"/>
    <dbReference type="SMR" id="C4YLE6"/>
    <dbReference type="PaxDb" id="5476-C4YLE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01664"/>
    <dbReference type="HOGENOM" id="CLU_000288_176_2_1"/>
    <dbReference type="OMA" id="HPCLVQI"/>
    <dbReference type="OrthoDB" id="2158884at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="27"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ43427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="520" mass="59082" checksum="9689B14FF64E5D9D" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLK6</accession>
    <name>C4YLK6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Hyphally-regulated cell wall protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_01724</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HYR1/IFF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLK6"/>
    <dbReference type="PaxDb" id="5476-C4YLK6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01724"/>
    <dbReference type="HOGENOM" id="CLU_006199_1_0_1"/>
    <dbReference type="OMA" id="CEVLTIY"/>
    <dbReference type="OrthoDB" id="4022214at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031573">
        <property type="entry name" value="Cell_wall_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021031">
        <property type="entry name" value="Hyphal-reg_cell_wall_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11765">
        <property type="entry name" value="Hyphal_reg_CWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15789">
        <property type="entry name" value="Hyr1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 13" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946608" description="Hyphally-regulated cell wall protein N-terminal domain-containing protein" evidence="13">
        <location>
            <begin position="21"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="Hyphally-regulated cell wall protein N-terminal" evidence="14">
        <location>
            <begin position="12"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ43487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="941" mass="98816" checksum="A68C67D5BDD6AA96" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLP8</accession>
    <name>C4YLP8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_01767</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
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        <property type="protein sequence ID" value="EEQ43529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="C4YLP8"/>
    <dbReference type="SMR" id="C4YLP8"/>
    <dbReference type="PaxDb" id="5476-C4YLP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01767"/>
    <dbReference type="HOGENOM" id="CLU_005316_4_3_1"/>
    <dbReference type="OMA" id="QLFTEYV"/>
    <dbReference type="OrthoDB" id="6093671at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytidine-5-)-methyltransferase activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:tRNA methylation"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
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        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
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        <property type="entry name" value="Pre-PUA_NSUN2"/>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25378">
        <property type="entry name" value="PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02011">
        <property type="entry name" value="RCMTNCL1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="64"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="425"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="667"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="450"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="667"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="684"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="181"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
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    </feature>
    <feature type="binding site" evidence="10">
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            <position position="239"/>
        </location>
        <ligand>
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        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
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        </ligand>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ43529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="713" mass="81257" checksum="3505C065C978D28D" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLR2</accession>
    <name>C4YLR2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
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                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
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                <person name="Srikantha T."/>
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                <person name="Lorenz M.C."/>
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            <dbReference type="PubMed" id="19465905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="57"/>
        </location>
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        <source>
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        <source>
            <dbReference type="EMBL" id="EEQ43543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLU6</accession>
    <name>C4YLU6_CANAW</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01815</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Yeast</name>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
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                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
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                <person name="Quinn J."/>
                <person name="Santos M.C."/>
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                <person name="Staggs R."/>
                <person name="Stansfield I."/>
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                <person name="Srikantha T."/>
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                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
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                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="HOGENOM" id="CLU_184882_0_0_1"/>
    <dbReference type="OMA" id="MYGQHFL"/>
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        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054415">
        <property type="entry name" value="SPO24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22044">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="102" mass="11562" checksum="95A40E3E2254AF93" modified="2009-07-28" version="1">MEQPTQFLQLSTESSEPFIIPNVSPVSSPKLLAKSTTDEQEEERNISGKLPKMGMMMNILKPLVVISEKEEEEQEEEEDAEKLIEDDAELISTRKLSILDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM03</accession>
    <name>C4YM03_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CAWG_01878</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM03"/>
    <dbReference type="SMR" id="C4YM03"/>
    <dbReference type="PaxDb" id="5476-C4YM03"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01878"/>
    <dbReference type="HOGENOM" id="CLU_000524_5_1_1"/>
    <dbReference type="OMA" id="LAYCSWC"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
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    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000009">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000020">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15 23" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="19">
        <location>
            <begin position="53"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="201"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="459"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="559"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="641"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="16">
        <location>
            <begin position="692"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="1068"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="EEQ43634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1157" mass="129327" checksum="4417C5CDB693A5E5" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM83</accession>
    <name>C4YM83_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pheromone alpha factor receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM83"/>
    <dbReference type="PaxDb" id="5476-C4YM83"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01961"/>
    <dbReference type="HOGENOM" id="CLU_038593_0_0_1"/>
    <dbReference type="OMA" id="MWMISKK"/>
    <dbReference type="OrthoDB" id="5402633at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038038">
        <property type="term" value="C:G protein-coupled receptor homodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004932">
        <property type="term" value="F:mating-type factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.920">
        <property type="entry name" value="Pheromone alpha factor receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="GPCR_STE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027458">
        <property type="entry name" value="STE2_TM1-TM2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28009">
        <property type="entry name" value="PHEROMONE ALPHA FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHEROMONE ALPHA FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02116">
        <property type="entry name" value="STE2"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="52791" checksum="D68B1E74CEC70A11" modified="2009-07-28" version="1">MNINSTFIPDKPGDIIISYSIPGLDQPIQIPFHSLDSFQTDQAKIALVMGITIGSCSMTLIFLISIMYKTNKLTNLKLNLKLKLKLKYILQWINQKIFTKKRNDNKQQQQQQQIESSSYNNTTTTSWGYKLFLFYLNSLILLIGIIRSGCYLNYNLGPLNSLSFVFTGWYDGSSFISSDVTNGFKCILYALVEISLGFQVYVMFKTSNLKIWGIMASLLSIGLGLIVVAFQINLTILSHIRFSRAISTNRSEEESSLSSSSSLSSDSVGYVINSIWMDLPTILFSISINIMTILLIGKLIIAIRTRRYLGLKQFDSFHILLIGFSQTLIIPSIILVVHYFYLSQNKDSLLQQISLLLIILMLPLSSLWAQTANNTHNINSSPSLSFISRHHSFDSSRSGGSNTIVSNGGSNGGGGGGNFPVSGIDAQLPPDIEKILHEDNNYKLLNSNNESVNDGDIIINDEGMITKQITIKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMG1</accession>
    <name>C4YMG1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_02041</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YMG1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02041"/>
    <dbReference type="HOGENOM" id="CLU_320537_0_0_1"/>
    <dbReference type="OMA" id="SFFSAHQ"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990526">
        <property type="term" value="C:Ste12p-Dig1p-Dig2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990527">
        <property type="term" value="C:Tec1p-Ste12p-Dig1p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002817">
        <property type="entry name" value="Transcriptional regulator MNL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052127">
        <property type="entry name" value="STE12_transcription_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="831"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="860"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="310"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="382"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="434"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="583"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="624"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="684"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="583"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="627"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="646"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="689"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ43792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="904" mass="100346" checksum="BE63926BC8B9AA94" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMJ4</accession>
    <name>C4YMJ4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitric oxide dioxygenase</fullName>
            <ecNumber evidence="4">1.14.12.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_02076</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 nitric oxide + NADH + 2 O2 = 2 nitrate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 nitric oxide + NADPH + 2 O2 = 2 nitrate + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="4"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMJ4"/>
    <dbReference type="PaxDb" id="5476-C4YMJ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02076"/>
    <dbReference type="HOGENOM" id="CLU_003827_12_0_1"/>
    <dbReference type="OMA" id="IMIGREK"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase NAD(P)H activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071500">
        <property type="term" value="P:cellular response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046210">
        <property type="term" value="P:nitric oxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19754">
        <property type="entry name" value="FHb_fungal-globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06184">
        <property type="entry name" value="flavohem_like_fad_nad_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.10:FF:000003">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000034">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000076">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0216">Detoxification</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin" evidence="16">
        <location>
            <begin position="17"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="17">
        <location>
            <begin position="164"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ43825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="400" mass="46667" checksum="16CFAADE98FABFF4" modified="2009-07-28" version="1">MTVASASIINNYFESKPLTPEHIQIIIDSVPILEHLDVQLTEKFYKRLLKQNPEFKPFFNETHQKLLRQPRIMIHFLIQYAKNIQDLTPMIDFIKKIASKHVGLQVKPEHYPKFGQVLINVIINLFPKQLVHDEFIEAWTLAYQNLANLLIKLESEQYVEKPWYGFKQFKVTRLQRECSDVKSLYITPVDGSPIPKPKRGQYLCMRWLLPGEKHEITREYSISEYPKNNEYRITIRYIPGGKVSNYIHNNINVGDIVYSGPPCGDCVYESSSKNLVFLAGGNGVTALLPMIEAGLTEGRQVKLLYSNRSTDSRSFGKLFQSYKLQYGDRFQVVEFLSRGRTIDPIDKFYRRSLTLEDLDFIVPEDDVYLIGPRTYMKMIEDYLKDRNITVKLDYFGPREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMQ2</accession>
    <name>C4YMQ2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bms1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_02136</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMQ2"/>
    <dbReference type="PaxDb" id="5476-C4YMQ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02136"/>
    <dbReference type="HOGENOM" id="CLU_009858_1_0_1"/>
    <dbReference type="OMA" id="MNLPRFK"/>
    <dbReference type="OrthoDB" id="119302at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="6">
        <location>
            <begin position="83"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="336"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="410"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ43883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="842" mass="94534" checksum="451FAA93DAB75218" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN01</accession>
    <name>C4YN01_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent rRNA helicase RRP3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP-dependent rRNA helicase rrp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_02239</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YN01"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02239"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_1_1"/>
    <dbReference type="OMA" id="NECTDRS"/>
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        <property type="component" value="Chromosome R"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17954">
        <property type="entry name" value="DEADc_DDX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044765">
        <property type="entry name" value="DDX47/Rrp3_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="14"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="212"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="370"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEQ43982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="399" mass="44380" checksum="1073D4EB5E05C6EA" modified="2009-07-28" version="1">MKFTKPTPIQSEAIPHALEGKDIIGLAQTGSGKTAAFAIPILQSLWHAQQPYFALVLAPTRELAFQIKDTFDALGSSMGLRSSCIVGGMDMMDQARDLMRKPHVIVATPGRIMDHLEHTKGFSLKNLKYLVMDEADRLLDMDFGPALDKILKVIPIKRTTYLFSATMTNKIEKLQRASLHNPVRVAVSSKYQTADNLVQSMMLVNDGYKNTILIHLLNEFMGKSIIVFTRTVAHAQRTALLARILGFNAVPLHGQLSQSQRLGSLNKFKSNQANILVATDVAARGLDIPSVDVVINYDIPTDSKAYIHRVGRTARAGRSGKSISLITQYDLEMYLRIESVLGKKLPKEDKPPKEVLDALHVHVDKATAEAIRQTKEIHDKRNGGGGRRRNRDDADREER</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN61</accession>
    <name>C4YN61_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial distribution and morphology protein 32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_02301</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MDM31/MDM32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN61"/>
    <dbReference type="PaxDb" id="5476-C4YN61"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02301"/>
    <dbReference type="HOGENOM" id="CLU_016236_3_0_1"/>
    <dbReference type="OMA" id="FAKEMVG"/>
    <dbReference type="OrthoDB" id="17678at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012571">
        <property type="entry name" value="Mdm31/Mdm32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068:SF0">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08118">
        <property type="entry name" value="MDM31_MDM32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ44042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="616" mass="69830" checksum="785BDAC0BA8BD222" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNB3</accession>
    <name>C4YNB3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="18">C-1-tetrahydrofolate synthase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_01369</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:23701"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:23702"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:22813"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:22814"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:20222"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:20223"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNB3"/>
    <dbReference type="PaxDb" id="5476-C4YNB3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01369"/>
    <dbReference type="HOGENOM" id="CLU_003601_2_0_1"/>
    <dbReference type="OMA" id="IKRVVDC"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000006">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001741">
        <property type="entry name" value="Formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001859">
        <property type="entry name" value="Formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF26">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00766">
        <property type="entry name" value="THF_DHG_CYH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="16">
        <location>
            <begin position="71"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="17">
        <location>
            <begin position="217"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ43146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1024" mass="111202" checksum="2B2D6F7F988D6FCE" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNK1</accession>
    <name>C4YNK1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase-assembly factor COX23, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_01463</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the COX23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNK1"/>
    <dbReference type="SMR" id="C4YNK1"/>
    <dbReference type="PaxDb" id="5476-C4YNK1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01463"/>
    <dbReference type="HOGENOM" id="CLU_153383_0_0_1"/>
    <dbReference type="OMA" id="NPENHRH"/>
    <dbReference type="OrthoDB" id="9971592at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051040">
        <property type="entry name" value="COX23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811:SF1">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="139" mass="16477" checksum="A2A05CD5C1BD90C8" modified="2009-07-28" version="1">MTEITETKKEADTPIIPKNTNTTATTTPTTKQQPTKLISDEVEKDTSKVDFTKGGVEEFKFYPDNPKSHRHKYKWSMKEPSKFYDPCEESRMASMDCLYRNQDDKYACQEFFDAYRECRKDFFRKKRQDNRDGAKGWGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNQ2</accession>
    <name>C4YNQ2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_02834</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required to maintain uniform nuclear distribution in hyphae. May play an important role in the proper orientation of the mitotic spindle into the budding daughter cell yeast. Probably required for normal progression of the cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YNQ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02834"/>
    <dbReference type="HOGENOM" id="CLU_000038_3_2_1"/>
    <dbReference type="OMA" id="LWANECT"/>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000235">
        <property type="term" value="C:astral microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000741">
        <property type="term" value="P:karyogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902850">
        <property type="term" value="P:microtubule cytoskeleton organization involved in mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000017">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000996">
        <property type="entry name" value="Cytoplasmic dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002357">
        <property type="entry name" value="Glutathione S-transferase class-mu 26 kDa isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF36">
        <property type="entry name" value="DYNEIN HEAVY CHAIN, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0415">Karyogamy</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="231"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="517"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="872"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="1214"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="1715"/>
            <end position="1742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ44561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="2058" mass="234330" checksum="A92DFE582B7C1E0C" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNQ9</accession>
    <name>C4YNQ9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_02841</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNQ9"/>
    <dbReference type="PaxDb" id="5476-C4YNQ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02841"/>
    <dbReference type="HOGENOM" id="CLU_017661_0_0_1"/>
    <dbReference type="OMA" id="WNQGLAY"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF169">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ44568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="353" mass="40646" checksum="ED08E1AF530BCC89" modified="2009-07-28" version="1">MLAKFKSPNAEVWKTFPPFDTPVPPSPFENEFLNKIYYASMNVTTPLTIAIIYFTSVHFINSIIRNKQIAKYNSKTSSESKVDITKLDDKKLQKILPTVPNSIAKTSIFKLFVFLHNVFLCLYSIWTFLGMSHTIATTMNLFEGNFLQSLVNYQPKKLDIFLHSVCDPKIGIFSRLLTNEKGLHNLEVFGWWFYISKFYEVLDTAIILLKGRPSSLLQSYHHAGAMMCMWAGIRYQSPPIWIFVVFNSFIHSLMYFYFSLSCLKIRVPNFFKRILTTMQITQFIVGGSIAILHSFVWIVDTSHVISPDNLKWVSCISTPDQALPILINVLYLLPLTALFTAFYIESYLKKKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNT5</accession>
    <name>C4YNT5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="12">General amino-acid permease GAP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_02868</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNT5"/>
    <dbReference type="PaxDb" id="5476-C4YNT5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02868"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_0_1"/>
    <dbReference type="OMA" id="INADAPF"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="11">
        <location>
            <begin position="6"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ44594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="467" mass="50823" checksum="C60C2B7C9D0D6586" modified="2009-07-28" version="1">METMDCCTVMSLGQLAVTFPVSGAFVTYNSRFIDPSWGFAMAWNYAMQWLVVLPLELVAAAMTVKYWDAKTNSAAFVVIFYVLIVAINFFGVRGYGEAEFIFSAVKVLAVLGFIILGIVLCAGGGPQGGYIGGKNWYIEGAPFPNGAKGVITVFVNAAFAFAGTELCGLAAAETENPRKSLPKACKQVFWRITLFYVICLTLVGLLVPWNDERLLGSSSADASASPFVISIRNAGIKGLPSVMNVVIMIAVLSVGNSSVYGSSRTLAALAASNQAPKIFGYIDKQGRPLVGIIAQLLVGLLCFLAASDKQGEVFNWLLALSGLSSIFTWGSINVCLIRFRRALAAQGRDTGELVFTSQVGVIGAIWGAFLNTVVLCLQFWIAVWPLHSSPSAEAFFSAYLTVPVVIVFYVGHKLWTKNWQVYIRAKDIDIDTGRRELDLDLVKQEVAEEKAYIASLPFYRRVYNAWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP22</accession>
    <name>C4YP22_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adherence factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2350934at2759"/>
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        <property type="component" value="Chromosome 3"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
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            <end position="143"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="179"/>
            <end position="273"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="612"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="203"/>
        </location>
    </feature>
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            <begin position="218"/>
            <end position="228"/>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="585"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="612" mass="68794" checksum="77B60E45C35C1B23" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPE4</accession>
    <name>C4YPE4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pseudouridine-5'-phosphate glycosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_03097</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
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                <person name="Srikantha T."/>
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                <person name="Berriman M."/>
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                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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                <person name="Cuomo C.A."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:pseudouridylate synthase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Indigoidine synthase domain"/>
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        <property type="entry name" value="Indigdn_synthA-like"/>
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        <property type="entry name" value="PsuG"/>
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        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="15694" checksum="0C935E925B5CB23D" modified="2009-07-28" version="1">MEYLETQGVFVGTYNPEKVDNLQVPGFYCRESGVPSPYGFESFAEAARVSYYQGMVGSGSVFCIPPPQETAMDSEYIRSVIEKANEKAKEVGVTGKKLTPFLLKEIAVATQGQSVESNIALVKNNARAAAEIAKELSQLVCKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPF0</accession>
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        <recommendedName>
            <fullName evidence="2">LsmAD domain-containing protein</fullName>
        </recommendedName>
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        <lineage>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
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                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
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                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
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                <person name="Logue M.E."/>
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                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
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                <person name="Sherlock G."/>
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                <person name="Silverstein K.A."/>
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                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
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                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="PaxDb" id="5476-C4YPF0"/>
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    <dbReference type="HOGENOM" id="CLU_009985_1_0_1"/>
    <dbReference type="OMA" id="YFTAPTW"/>
    <dbReference type="OrthoDB" id="2275718at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
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        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025852">
        <property type="entry name" value="SM_dom_ATX"/>
    </dbReference>
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        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="2">
        <location>
            <begin position="158"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="446" mass="50536" checksum="22FDD3187E92EA16" modified="2009-07-28" version="1">MKGQSKNGHRRSNSRFANDDKRLVYLTSKAMGKKCIATITDGSRYQGLLVGSDLSPLSVVLLKPQLVGSSLLNEKNNLDKLPENLIIQAKDLIDLEVDVDLSEPVKPPHEFKTDADISGKMQIKERELERWVPDDEVELTLEDDGSEWDQFKVNQEKFGVESSYDEHLYTTRIDTSAPDYHERVAKAERIAKEIEQQATTDRHILEERGVVVDDSGVDEEDKYSGVDRRGDELMAALRNASISKPAQQGTTTHHHHDPAIVSSSKQAKPESIPPKPPVPNESFRLNAQSEINSLREFSANFKIPHKMPQDLLPILAKDKMKQDEILKKQQDHTKKEPKTYKLNPKAAVFTPSSKHATISSPKKSPRPYSNGNVKKHYQISAADFFGVNKVPTKDGQTTKIKEFKCGFNMFVTTRRKHKEYEKSFQTPPTWECTVDDAHDKLLRRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPW8</accession>
    <name>C4YPW8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_02522</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPW8"/>
    <dbReference type="PaxDb" id="5476-C4YPW8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02522"/>
    <dbReference type="HOGENOM" id="CLU_1396120_0_0_1"/>
    <dbReference type="OMA" id="SFERDYW"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006838">
        <property type="entry name" value="ADTRP_AIG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989">
        <property type="entry name" value="ANDROGEN-INDUCED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989:SF16">
        <property type="entry name" value="AT02829P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04750">
        <property type="entry name" value="Far-17a_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ44257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="195" mass="23014" checksum="6FC2A939ADBC48BE" modified="2009-07-28" version="1">MTRQGLISLVSLAICCSGLYDCFQLELPPGLVKGGHFQFLTNVSLILTIIYILQTIVTPTSYNLRLQYNVVSNLEFTVTVSYWVMHLILPHWLNTNSFERDYWLDFKIHIWPYVYLIFDNQEQIKPKKSWTLTAIIIVVYWCYIERVVSVNDDGITRFPYPFLNNKTLVERFFRVTAMWLLSCLNYFVLGFRNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPY6</accession>
    <name>C4YPY6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPY6"/>
    <dbReference type="PaxDb" id="5476-C4YPY6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02540"/>
    <dbReference type="HOGENOM" id="CLU_002392_2_1_1"/>
    <dbReference type="OMA" id="STYITEW"/>
    <dbReference type="OrthoDB" id="8883818at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000896">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046351">
        <property type="entry name" value="UTP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="205"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="743" mass="85096" checksum="D8D81FF617A39B06" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ85</accession>
    <name>C4YQ85_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_02641</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ85"/>
    <dbReference type="PaxDb" id="5476-C4YQ85"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02641"/>
    <dbReference type="HOGENOM" id="CLU_063260_0_0_1"/>
    <dbReference type="OMA" id="FDDCGVY"/>
    <dbReference type="OrthoDB" id="5065855at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.395.10:FF:000008">
        <property type="entry name" value="Ulp1 protease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044613">
        <property type="entry name" value="Nep1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468:SF1">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="139"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="47"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ44374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="351" mass="40680" checksum="7B28A91C158B48AB" modified="2009-07-28" version="1">MASVIYDERKGYCVTNEPINKVNENEGIINNGLQTLPWDLYLPEETDDLSSASDNTSTSTPKPLTKQEKREAKQLKKINASRRRKLKREQELDNKRESKFPDFKPYLAKQELKALFSSIVKSTCQNSEADAKILQYHSIALYKSDLEHILPGEWLNDNNISLIYELIIQIFIKHGRKFSNQIQLLFPSLIQLLMHFPDDVESLLPVDELKSSKLIFLPINFIDEMDVDLEDANNGDHWSLGVLSLLDNTLYVYDSMQIDDDEISEIQLKKLVQKLQSCNTIVHGKLKVRHLKCDQQQNFDDCGVYVIMITCYLINQLLHQDEMSLDISRVKFNPLDARLYIMKLISRLIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ88</accession>
    <name>C4YQ88_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_02644</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ88"/>
    <dbReference type="SMR" id="C4YQ88"/>
    <dbReference type="MEROPS" id="T01.973"/>
    <dbReference type="PaxDb" id="5476-C4YQ88"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02644"/>
    <dbReference type="HOGENOM" id="CLU_035750_4_3_1"/>
    <dbReference type="OMA" id="YVLNDNM"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03752">
        <property type="entry name" value="proteasome_alpha_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000009">
        <property type="entry name" value="Proteasome subunit alpha type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 6 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="8">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ44377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="251" mass="27808" checksum="B5EE9A670D1D014B" modified="2010-10-05" version="1">MSRRYDSRTTIFSPEGRLYQVEYAQEAISNAGTAIGILSPEGVVLACEKKVTSKLLDDDGSAEKLYIINDQMICAVAGMTADASILVNNARIQAQQYLKLYDEEIPCEMLINRVCDVKQGYTQHGGLRPFGVSFLYAGYDDRYQFQLFTSNPSGNYSGWKATSIGANNSAAQTLLKKDYKDDLTLKDACELAIKVLSKTMDASNINSEKLEFATLSLGKDNKVLHKIWNDKDIDILIKASGVLNEKNSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ91</accession>
    <name>C4YQ91_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ91"/>
    <dbReference type="PaxDb" id="5476-C4YQ91"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02647"/>
    <dbReference type="HOGENOM" id="CLU_1034380_0_0_1"/>
    <dbReference type="OMA" id="HEDNEHE"/>
    <dbReference type="OrthoDB" id="4012581at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031426">
        <property type="entry name" value="DUF4667"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15700">
        <property type="entry name" value="DUF4667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="280" mass="31640" checksum="B9D95A7339A675FB" modified="2009-07-28" version="1">MSRHSSRKCSLAIESPIDDSCNNPLNAFLIYSGKTDTHSNNNNGADDEMATTDESMSPLASSTFLSPMTPPGSRNTTQLSNQQLTKPLRCHRRPSMIKCTSLPELTAMSTHTVTTSPPLSSLITNSTTHAILGNRRISICDLDNFTGEIDYVKQQQHEQHQQQLQSPDIANFMYCNLSTSDIDKTPRKFSFHHRPKTAPGMMTGGSDETPQNHDHEDNEHEYGPKQQEQESMEIDKEKEEVATQNTQLPHHYIENLASFQFRNHKRRNSTALKFEEPKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQG2</accession>
    <name>C4YQG2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Suppressor of toxicity of sporidesmin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_02720</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQG2"/>
    <dbReference type="PaxDb" id="5476-C4YQG2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02720"/>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="OMA" id="WHDVCYE"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="753"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="786"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="825"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="869"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="907"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1032"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="410"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ44451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1068" mass="121419" checksum="8CC8594F2B10C6C0" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQL6</accession>
    <name>C4YQL6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQL6"/>
    <dbReference type="PaxDb" id="5476-C4YQL6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02775"/>
    <dbReference type="HOGENOM" id="CLU_1982386_0_0_1"/>
    <dbReference type="OMA" id="NSEYQRE"/>
    <dbReference type="OrthoDB" id="3999982at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="136" mass="15618" checksum="61EAE4D32046B95E" modified="2010-10-05" version="1">MLNIAKSTESRNTILRKLGIFGSIAIGLFIIGKKHIAYQKNHRHELESDSSTLSSRHQDEEFGYVSSRPGFPLTNPNLDYSSPDRKSKYVGSGDAFSTRRPGDRLSLWNMVKMRWFPDEVEESKYYTPSRSDKLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQQ3</accession>
    <name>C4YQQ3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="9">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_02813</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="9"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQQ3"/>
    <dbReference type="PaxDb" id="5476-C4YQQ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02813"/>
    <dbReference type="HOGENOM" id="CLU_004585_4_0_1"/>
    <dbReference type="OMA" id="DYPDATT"/>
    <dbReference type="OrthoDB" id="1470711at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17932">
        <property type="entry name" value="DEXQc_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.486.10">
        <property type="entry name" value="PCRA, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF2">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE SRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="13">
        <location>
            <begin position="15"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="14">
        <location>
            <begin position="326"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="790"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="820"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="820"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ44542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="864" mass="98475" checksum="9D9ECFC8CA71FF75" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQX4</accession>
    <name>C4YQX4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Restriction of telomere capping protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_04471</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RTC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQX4"/>
    <dbReference type="PaxDb" id="5476-C4YQX4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04471"/>
    <dbReference type="HOGENOM" id="CLU_056041_0_0_1"/>
    <dbReference type="OMA" id="THVLANE"/>
    <dbReference type="OrthoDB" id="128308at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039024">
        <property type="entry name" value="RTC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028094">
        <property type="entry name" value="RTC4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391:SF1">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14474">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01312">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Restriction of telomere capping protein 4 C-terminal" evidence="9">
        <location>
            <begin position="170"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="86"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ46127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="350" mass="40481" checksum="FF7D154EB6DA9679" modified="2009-07-28" version="1">MFSPTKLSPQASKTYKKRPKGKILVHDNALETSKVKKLGEYQEIIAKPRKSLDPFDLIDINHIEKSTPSPVKMAKKRKTETGIKVEGLLEISDDDDNDNDKSKEKDKSQPKTLNEKFDSNNILHSLDQQNRSKYDDVLKKYKKKKIPKPIVSRKELLARANKYMDLIPKILGGKLNTSVYYEYAKAEQMKSDRETMPASDKWRIKWEKYYGGYYGFQRQSIIGAYILDRYEKKLTKFCKDNKTARYWNMSQFSTYVLANEIIIRMIMEDMNLDFDKAEKFCLETVDYGIVVADSIEVDYDNGLSQEKTTTKKSISSTKSKLLPISLNADDSSSDEESIFRVKKSGKTRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR02</accession>
    <name>C4YR02_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">G1/S-specific cyclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_04499</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">G1/S-specific cyclin essential for the control of the cell cycle at the G1/S (start) transition.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR02"/>
    <dbReference type="SMR" id="C4YR02"/>
    <dbReference type="PaxDb" id="5476-C4YR02"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04499"/>
    <dbReference type="HOGENOM" id="CLU_033561_0_0_1"/>
    <dbReference type="OMA" id="QFYPNIY"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000045">
        <property type="term" value="P:regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20559">
        <property type="entry name" value="CYCLIN_ScCLN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000080">
        <property type="entry name" value="G1/S-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014399">
        <property type="entry name" value="Cyclin_CLN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyclin_CLN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5 6" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="79"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ46155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="465" mass="53177" checksum="97CC07FB3A07C230" modified="2009-07-28" version="1">MFPNSPDAFHQVRMMQSSIKASNFKLQSMEFRCHSNNVCEYQMEMLHHLLSVEAKTLPSLSLIEQQPEIKLGMRPLLLDFLMEVITILNLSRSTFPLTVNLIDRYCSTRIVKKQHYQLLGLTSLWISCKNLDSKFKVPTLNDLRKICVDSYYKELFVEMEKHILKSLEWVVNAPTFDAFIDLYSNLLISNSSNFEVANIIKKSSHKIKLFSNYIGELFQFYPNIYYDYTSSQIALIAILITVLTLKIPVDLISLLNFYNGLVKTEMFKSNVEQGAEDQFEEILSVDSFKSLFNKSFFKNLIKIIDNPPSSLKIKYFAENGKYSVLMKQLVTTASNTLKCILDPVPTTPKANSFVKHQQQQHHYHPRPPMSINTSMIPLTPVSNSTSPNRFSPDQIFSENESTPGIAFGTMTPDSQSTSPGEKRSYECIDELEIGTSTIAGYTLKNHDTLKRSKSANYGTLFYLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR59</accession>
    <name>C4YR59_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_04558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR59"/>
    <dbReference type="PaxDb" id="5476-C4YR59"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04558"/>
    <dbReference type="HOGENOM" id="CLU_016884_0_0_1"/>
    <dbReference type="OMA" id="KLIVQHH"/>
    <dbReference type="OrthoDB" id="4094279at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="888" mass="103704" checksum="F57C3DCC90E81FA8" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRC6</accession>
    <name>C4YRC6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRC6"/>
    <dbReference type="PaxDb" id="5476-C4YRC6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04625"/>
    <dbReference type="HOGENOM" id="CLU_028918_0_0_1"/>
    <dbReference type="OMA" id="KWMNNPV"/>
    <dbReference type="OrthoDB" id="3598904at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="699" mass="79290" checksum="A3798BA44823EB9D" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRD2</accession>
    <name>C4YRD2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_04631</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRD2"/>
    <dbReference type="PaxDb" id="5476-C4YRD2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04631"/>
    <dbReference type="HOGENOM" id="CLU_026663_1_0_1"/>
    <dbReference type="OMA" id="YRYKMEK"/>
    <dbReference type="OrthoDB" id="10250831at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071074">
        <property type="term" value="F:eukaryotic initiation factor eIF2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11561">
        <property type="entry name" value="W2_eIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000031">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.350:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF7">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="7">
        <location>
            <begin position="254"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="165"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ46285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="419" mass="46518" checksum="086A366900563CBA" modified="2009-07-28" version="1">MSFINICRDNTDPFYRYKMPPIQSKTEGRGNGIKTAIVNLAEVARALNRPPAYLVKFFGYELGAQTQILNDRYLVNGAHDSNEFTDSLDGFINKFVLCGSCKNPETEIVLKGKDSLERDCKACGKISMIDPKHKLYSFIVKNPPDNKKGKKSATATANVVGGGKSISDIASGHNGQGGEPGNNNNNNNNGGGANGENGENGEGYEDDDEDDDLLAKKINAEVAQLKAMEIKDDEWAVDMSQEAIAARARELEGLSLQNNKFDEFGEWLLKESNGSKDDLPSDVEIYKRIVELEIADTPETLQVLGQVLFDDDIINQIEPHVGLLTKLINGDEEFEKALLGGLERFFGLEKPNLIPQIPKILHGFYDRDLISEEVLIKWGSKVSKKYVPKDVSKKVRKAAKPFVKWLQEAEEEEEESDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRF3</accession>
    <name>C4YRF3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_04652</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRF3"/>
    <dbReference type="PaxDb" id="5476-C4YRF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04652"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_1"/>
    <dbReference type="OMA" id="MRATTIH"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08284">
        <property type="entry name" value="FDH_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF2">
        <property type="entry name" value="DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="25"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="195"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ46306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="40245" checksum="37C20FCD083792AF" modified="2009-07-28" version="1">MKAIVFYAPYDVRTEERPTPKIKDPKDVIVKVRYSGLCGTDLHSYRGHIKGPVGTIIGHEFVGIVVATGDNITKFSIGDDVISNFSIECGECWYCKHGYSGQCNVTNTFGKVGLDGGQAEYVRVPYAETTLTKKPSTTNSNDDVDDSVYVLMADIFTTGYYGVKKIKDFLSILAAEGIKPQSFEETTILQLGAGPVGLCALRILKYFGFGKVVVVDNVPSRLEEAKRLGATKVINFETEPDGIKKYITEETDGVGFDAVLEVVGSAAAHKTSFDAVRRNGFISSIGMGHEPFPFNGLDVYLKNINMSFGRCHSWSLFPESLAIFEEMKGDLASFIDYKAKLEDSKEAFDMFDKHKVKKIVFDLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRG0</accession>
    <name>C4YRG0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Casein kinase II subunit beta</fullName>
            <shortName evidence="3">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_04659</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRG0"/>
    <dbReference type="PaxDb" id="5476-C4YRG0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04659"/>
    <dbReference type="HOGENOM" id="CLU_034027_3_2_1"/>
    <dbReference type="OMA" id="DADFGRC"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030291">
        <property type="term" value="F:protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000010">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF39">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ46313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="213" mass="24826" checksum="A8A518C743DAE939" modified="2009-07-28" version="1">MANEEYVTDSSSDFTEYWIDLFLGIKGNEYFCDIDDEYIRDRFNLTGLNSEVSKLPILIDIITDVIDIESQPEEHKDSLEHNARILYGLIHARYILTTRGLNKMFEKFRSGDFGYCPRVHCQLNPLLPVGLNDQPRMASVKLYCSKCEDLYNPKSGRHSAIDGAYFGTSFPAMFFQNFPNTVPIHAKETYVPRVFGFKLHEYSKLNRWRELQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRQ6</accession>
    <name>C4YRQ6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRQ6"/>
    <dbReference type="PaxDb" id="5476-C4YRQ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04759"/>
    <dbReference type="HOGENOM" id="CLU_082191_0_1_1"/>
    <dbReference type="OMA" id="PEDYITP"/>
    <dbReference type="OrthoDB" id="3063476at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF1">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="202" mass="21409" checksum="C31EA1EA8CA65CFD" modified="2010-10-05" version="1">MAYSTGRGGAGNIHSNKNKTSENNVLTPQKSTTFSPQQSNDDGSTPLQKVTSQNKRVYYSTGRGGAGNIKTSDQLPSPTLIPQGSNTPHLHTAKVSTGRGGYGNMVNNDDPELTRKLQDVDGEPASPKDDLYAITSNKSFSVGRGGFGNVISKSRSTDSQKDGNGGNGSGAIVPELYTVTSQPEKKVKKKQGFLGKIKEIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSL5</accession>
    <name>C4YSL5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease H</fullName>
            <ecNumber evidence="4">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_05083</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="4"/>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSL5"/>
    <dbReference type="PaxDb" id="5476-C4YSL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05083"/>
    <dbReference type="HOGENOM" id="CLU_587919_0_0_1"/>
    <dbReference type="OMA" id="HAITDWI"/>
    <dbReference type="OrthoDB" id="407198at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09280">
        <property type="entry name" value="RNase_HI_eukaryote_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000241">
        <property type="entry name" value="Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.970.10:FF:000002">
        <property type="entry name" value="Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF30">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="11">
        <location>
            <begin position="51"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="11">
        <location>
            <begin position="284"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ46718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="465" mass="53830" checksum="DF01D080E979D3C1" modified="2009-07-28" version="1">MPYYAVVNGREEGVFSSWQDCRPHVFAYKGAHFRKFEIRNEAEEYYQNDGDYFIYPIYVDGACRYNGCPHAEAGYGVYYGDGDSRNVSVPLDDVDPDGIIPTNQRAELWAMNHALRNIWNELQEDTEDGKAVIYSDSIYAIKCLTKWPNKWTQNGWLNVHGQTISNYDLVTKNYELYEWINDEYDDRGWGELDLIHVKGHSGNDGNEEADNLANLAADRYGYQSSSSSSVWTIMPYYAVARGREVGIYSSWRECRPQVYCCKGARYRKFENLIEAKEYCENDGRYYIYPVYVDGACRNNGRENAKGGYGVYYGDEDPRNVSVPLDRVDPNGIRPTNQRAELWAMNHALKNILNELQDETEKGKAIIYSDSIYAINCLTKWPEKWIYNGWQNSRGRTISNQELIEENYDLYESINEEYDDRDWGSLRFVHVKGHSGVEGNEEADRLANLAVDEYGQRSIFRSIFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSL6</accession>
    <name>C4YSL6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyrate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_05084</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3"/>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSL6"/>
    <dbReference type="PaxDb" id="5476-C4YSL6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05084"/>
    <dbReference type="HOGENOM" id="CLU_035117_6_1_1"/>
    <dbReference type="OMA" id="MGKKVWH"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000070">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001411">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="8">
        <location>
            <begin position="19"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="9">
        <location>
            <begin position="207"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ46719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="354" mass="39044" checksum="A8F6830813720063" modified="2010-10-05" version="1">MLRTSIRAFSTQPRLSTNYGFIGLGLMGQHMARHVYNQLEPSDKLYVYDVDPKHTTQFLTEVTSQTPQNAPLLTPLNSLKDFTTEVDSQLDFIVTMVPEGKHVKSVVSELVGHYKSTGNYDPSIKTTFLDSSTIDIPTSRDVHQLVKSSIPEFDFIDTPVSGGVAGARKGTLSFMLSRETHDDIDPSLTALLSKMGINIFPCGATHGTGLAAKLANNYLLAITNIAAADSFQLAKSFGLNLQNYAKLVAVSTGKSWASVDNCPIPGVYPDNNLPSDVNYEGGFITKLTRKDVVLATESAKFNNRFLMLGDIGRHWYDKACEREDIANRDLSVLFEWLGDLKQNEKGDVIDVKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YST7</accession>
    <name>C4YST7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_05156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YST7"/>
    <dbReference type="PaxDb" id="5476-C4YST7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05156"/>
    <dbReference type="HOGENOM" id="CLU_065604_0_0_1"/>
    <dbReference type="OMA" id="GYWLVDW"/>
    <dbReference type="OrthoDB" id="5582146at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="363" mass="42324" checksum="4697DE2DEC3E9D26" modified="2009-07-28" version="1">MENLYTALSISLITDDKRFVIVSDDSNKAIPKFTSMLVNTCSFDTSQYCVIDLLNVHTTIDLIHQMTNFRDNQYFLKNIIIWQNVQYLTTNQHKSLYKLILQIDQFGLRGVRGKPIDIAIGNDEIISINRPQLFTIIMAFDYKAFSKKLYIYLKEKFWFAVNYNNVEEEDEQESDGLPQDSQYQETILGLRNSLADVFISPDIKGYIYSLIVFTRCHRLASLSPKSTRLPTMAIDYMHDFCKCLALWKNQSKLNQELFITPAYVKLAFRKIGYWLVDWEYNEMFAKDTQSSVLVDDDSNTLNNEIDYQKRLEISMLTGDWYGSDYFFVNEYLKSSKSKLDKKSPTGYTNKIIEDVISSVRPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT15</accession>
    <name>C4YT15_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_05713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT15"/>
    <dbReference type="PaxDb" id="5476-C4YT15"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05713"/>
    <dbReference type="HOGENOM" id="CLU_101036_1_1_1"/>
    <dbReference type="OMA" id="TMQEDHE"/>
    <dbReference type="OrthoDB" id="2209940at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="entry name" value="Haem-degrading domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010371">
        <property type="entry name" value="YBR137W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255:SF1">
        <property type="entry name" value="UPF0303 PROTEIN YBR137W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="HbpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008757">
        <property type="entry name" value="UCP008757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="GlcG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ47151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="168" mass="19130" checksum="4F96EA4DA6F6E753" modified="2009-07-28" version="1">MTHEIYSYSLEDLDKLEQDLKFPKFNADIAWQLGSLARSLALEKYPQKPIIINITLSNGHNLFQTATINGTILDNDKWVNRKINTVIRFEKSSFYIGQKLRNKMKSLEEANFISSIDYATHGGSIPLRLINFDGIIGALTISGLAQEEDHLFAIEVVKQFLETLNLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTA7</accession>
    <name>C4YTA7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_05393</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTA7"/>
    <dbReference type="SMR" id="C4YTA7"/>
    <dbReference type="PaxDb" id="5476-C4YTA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05393"/>
    <dbReference type="HOGENOM" id="CLU_823854_0_0_1"/>
    <dbReference type="OMA" id="LDQYHKP"/>
    <dbReference type="OrthoDB" id="4026433at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007567">
        <property type="entry name" value="Mid2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04478">
        <property type="entry name" value="Mid2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Mid2" evidence="3">
        <location>
            <begin position="224"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ46848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="337" mass="36489" checksum="82A80BD065DD7D31" modified="2010-10-05" version="1">MEKLSINNNNNNRRYQSRRFDGITIIRIVVLVFIVTVSTYFVNSYTCNQPHHNHSTRPSHYLPINGTHGLMNNDDSLHNKGAIGHYNTTVSLERRADENNSTTNGLFPSTSSSTFIFTPSSSSSSTFQQSRSSPQTTSTSSFVATTSSFQQETSQTSIPDTTTDFSFSSFSEAPTTSTTSSTSEFSSTPQETSNTVTSTSSTSTSSSSSPTSSPATTSASQHVTTFSSVDNGKTIVVTRTSVISSSPTASNSNNNKNNDNGGGLSHTNRIVVGVVVGVGGSILIGLLAVLFYLRKRNNRDYEGGWTFWRKNEKLGSDEFFNGELGVRDRNINQGSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTC7</accession>
    <name>C4YTC7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribulokinase/uridine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTC7"/>
    <dbReference type="PaxDb" id="5476-C4YTC7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05414"/>
    <dbReference type="HOGENOM" id="CLU_067202_0_1_1"/>
    <dbReference type="OMA" id="QNAHYID"/>
    <dbReference type="OrthoDB" id="6362633at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="226" mass="25677" checksum="05756C0077356750" modified="2009-07-28" version="1">MVHQITYTSNEIPQLCDRVHKDYLSKRKSDSQPRYLISLAGVPGSGKTTFANAIAKRLSTFAKVVVLSQDGFHLYRSELTLMADPKEAFRRRGAPFTFNAQAFVNLISKLKDRSQTIKAPSFDHKLKDPIEDDIVIHGDVDIIIIEGNYVSLRDKYWDEIENFVDDTWFIKTPENLVRERIIKRHLNAGIAANEKEAAERADGSDMQNAHYIDGNSKPTKVLILSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTV3</accession>
    <name>C4YTV3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein FAM96A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_05599</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTV3"/>
    <dbReference type="PaxDb" id="5476-C4YTV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05599"/>
    <dbReference type="HOGENOM" id="CLU_075876_1_1_1"/>
    <dbReference type="OMA" id="NQCISAR"/>
    <dbReference type="OrthoDB" id="2746at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000004">
        <property type="entry name" value="cytosolic iron-sulfur assembly component 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ47044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="222" mass="24212" checksum="2BC208C22BACEC26" modified="2009-07-28" version="1">MSDPINANPTIIDVADLPTRLNNDNNNNNDNNYQTTNKLNLKKNKQIISQLVSLSLLNPDESPEAADDETSLSSNEENEDDDFDPIDEQEIFDLIATISDPEHPLTLAQLAVVNLSDIKITNPPNCGGDGGDGGGGGISEVLIKITPTITHCSLATLIGLGIRVRLDRSLPSRYRIKILIKEGTHQSENQVNKQLNDKERVAAACENDQLLNVISQMLSTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTV4</accession>
    <name>C4YTV4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trafficking protein particle complex subunit 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_05600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YTV4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05600"/>
    <dbReference type="HOGENOM" id="CLU_008469_0_0_1"/>
    <dbReference type="OMA" id="FHIVRGY"/>
    <dbReference type="OrthoDB" id="6278596at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021773">
        <property type="entry name" value="TPC11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374">
        <property type="entry name" value="FOIE GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11817">
        <property type="entry name" value="Foie-gras_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 11" evidence="3">
        <location>
            <begin position="332"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="703"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="947"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1031"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="717"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="950"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ47045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1298" mass="149669" checksum="F76DEA2F1CD3DAC9" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-12-14" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCU0</accession>
    <name>MTND_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="1">ARD'</shortName>
            <shortName evidence="1">Fe-ARD</shortName>
            <ecNumber evidence="1">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="1">ARD</shortName>
            <shortName evidence="1">Ni-ARD</shortName>
            <ecNumber evidence="1">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ADI1</name>
        <name type="ORF">CAWG_00324</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="1">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="1"/>
    <dbReference type="EC" id="1.13.11.53" evidence="1"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCU0"/>
    <dbReference type="SMR" id="C4YCU0"/>
    <dbReference type="PaxDb" id="5476-C4YCU0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00324"/>
    <dbReference type="HOGENOM" id="CLU_090154_1_1_1"/>
    <dbReference type="OMA" id="NNYIKLM"/>
    <dbReference type="OrthoDB" id="1867259at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000099">
        <property type="entry name" value="1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0223">Dioxygenase</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0486">Methionine biosynthesis</keyword>
    <keyword id="KW-0533">Nickel</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000414354" description="Acireductone dioxygenase">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <sequence length="178" mass="21008" checksum="F4F6A591F7D137CC" modified="2010-10-05" version="1">MVEFYFHDNKDTLENFTEDHNSGEPVSFDQLAEIGVIYKYITTQEELDALATEREYKNRDVVTLNLPAFNNDIDAYNAKMQQFYKEHYHEDEEIRYIAEGEGYFDVRDKQDRWIRAKLSPYDLLILPAGIYHRFTLTNAAKHVKAVRLFKDEPKWEAINRDTGKNTEARELYAKTIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD83</accession>
    <name>C4YD83_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_00473</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD83"/>
    <dbReference type="PaxDb" id="5476-C4YD83"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00473"/>
    <dbReference type="HOGENOM" id="CLU_028484_1_0_1"/>
    <dbReference type="OMA" id="LPFAPNM"/>
    <dbReference type="OrthoDB" id="17415at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12710:FF:000002">
        <property type="entry name" value="Protein arginine methyltransferase NDUFAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF5">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ42269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="540" mass="63006" checksum="543CAB7EF297755A" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDC3</accession>
    <name>C4YDC3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Alternative oxidase</fullName>
            <ecNumber evidence="17">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAWG_00514</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 17">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="16 17">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the alternative oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="17"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDC3"/>
    <dbReference type="PaxDb" id="5476-C4YDC3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00514"/>
    <dbReference type="HOGENOM" id="CLU_041974_3_0_1"/>
    <dbReference type="OMA" id="HREPRTF"/>
    <dbReference type="OrthoDB" id="16906at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098803">
        <property type="term" value="C:respiratory chain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009916">
        <property type="term" value="F:alternative oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01053">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.140:FF:000002">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.140">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002680">
        <property type="entry name" value="AOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038659">
        <property type="entry name" value="AOX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803:SF3">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01786">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005229">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="14 17 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 17 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005229-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEQ42309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="365" mass="41924" checksum="B38C21C002482074" modified="2009-07-28" version="1">MLTASLYKQLPVLTTTATSTYSFIRLSSTLAAPPHSTTTTSPSSPAFHQPNHPQQFANPNTSVFDVSTRIYTQEGIDNNNDTKFLTKAPYPHPVFPQDECENVTVTHRETKTLGDKISFRSIQFMRQCFDLVTGYAVPKTNNPEEFKGTRWEMTEGKWLTRCIFLESVAGVPGSVAGFLRHLHSLRMLRRDKAWIETLLDEAYNERMHLLTFIKIGKPSWFTRSIIYVGQGVFTNVFFLLYLLNPRYCHRFVGYLEEEAVRTYSHLLDELAVPGKLPAFETMKIPEVAVQYWPELTPKSSFKDLILRIRADEAKHREVNHTFANLEQKTDRNPFALKIEGLNKPQPNHGINVMRPTGWEKQDLQL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-06-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDC4</accession>
    <name>SHO1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>High osmolarity signaling protein SHO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Osmosensor SHO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SHO1</name>
        <name type="ORF">CAWG_00515</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity. Mediates resistance to oxidative stress. Controls the activation of the CEK1 MAP kinase. Influences the molecular weight and polymer distribution of cell wall mannan. Involvoved in invasive filamentation into semi-solid medium and plays a role in morphological dimorphic transition which is a differentiation program characteristic of C.albicans and which is known to play a major role in pathogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms homooligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SHO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDC4"/>
    <dbReference type="SMR" id="C4YDC4"/>
    <dbReference type="PaxDb" id="5476-C4YDC4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00515"/>
    <dbReference type="HOGENOM" id="CLU_043316_0_0_1"/>
    <dbReference type="OMA" id="KNGKWWQ"/>
    <dbReference type="OrthoDB" id="5983572at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11855">
        <property type="entry name" value="SH3_Sho1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000213">
        <property type="entry name" value="High osmolarity signaling protein SHO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035522">
        <property type="entry name" value="Sho1_SH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF20">
        <property type="entry name" value="HIGH OSMOLARITY SIGNALING PROTEIN SHO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0728">SH3 domain</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000410364" description="High osmolarity signaling protein SHO1">
        <location>
            <begin position="1"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="2">
        <location>
            <begin position="34"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="64"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="2">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="123"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="324"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="268"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="385" mass="40816" checksum="3A846D7FF4797BCB" modified="2009-07-28" version="1">MGFSLSNFTSDPFAISTVSFGIMAWVVAIAGAASSKQENFPHFSWWGISYQIVIILIIFVLYANNNIELYKFTLVGLVSIAFIYTTNSTNNLIYNSNSAGNLCCAAGCILLSILNLIWILYFGGHPESPTNQFIDSFSLRGQGHEQLGSGSHNHNANNANNNIPIGAGNAIIGKGEMSPYDDRFAASGVNQPTSESLRLASGPQMGNGPFTTTGAIINPNLQQPLSGSIGGSAHHTPTNINNNNNNNTGYMTSSHLTGLENFSSPHVPGSGTGAGLGVGAGRDLTHNSNGGGGSGGGPASANNSNNTNKRNTIYTDSETGTGITFRYKAKALYSYDANPDDINEISFVKDEILEVDDIDGKWWQARRANGQVGICPSNYVKLLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDC5</accession>
    <name>C4YDC5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_00516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDC5"/>
    <dbReference type="PaxDb" id="5476-C4YDC5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00516"/>
    <dbReference type="HOGENOM" id="CLU_451986_0_0_1"/>
    <dbReference type="OMA" id="GVNMPWD"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052942">
        <property type="entry name" value="LPS_cholinephosphotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43404">
        <property type="entry name" value="LIPOPOLYSACCHARIDE CHOLINEPHOSPHOTRANSFERASE LICD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43404:SF1">
        <property type="entry name" value="MNN4P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="2">
        <location>
            <begin position="376"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="2">
        <location>
            <begin position="495"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ42311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="708" mass="82803" checksum="341A7ECBCB2238E3" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDM3</accession>
    <name>C4YDM3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Ubiquitin-activating enzyme E1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAWG_00620</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">WO-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDM3"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <keyword evidence="6 11 13" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="8 11 14" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="6"/>
            <end position="416"/>
        </location>
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            <end position="624"/>
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            <begin position="219"/>
            <end position="249"/>
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            <begin position="569"/>
            <end position="582"/>
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            <begin position="588"/>
            <end position="610"/>
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            <position position="179"/>
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            <begin position="28"/>
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            <position position="52"/>
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        <ligand>
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            <begin position="60"/>
            <end position="63"/>
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        <ligand>
            <name>ATP</name>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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            <end position="128"/>
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            <name>ATP</name>
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            <position position="164"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        <location>
            <position position="167"/>
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            <position position="450"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF00899"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ42409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="624" mass="70954" checksum="F0CC60D9DFDE8F19" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDN1</accession>
    <name>C4YDN1_CANAW</name>
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        <recommendedName>
            <fullName evidence="6">EXS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_00628</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF46">
        <property type="entry name" value="PROTEIN ERD1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EXS"/>
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        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
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        <location>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="463" mass="54572" checksum="E1D4D655D494C2B3" modified="2009-07-28" version="1">MGEETPNQTHEILFNDFIPLSFRITVAIHFGLILWLILNLLLTNFTSINVLHLLKLSYTPHNYTHLDDLSHNQDTNVNTNNNHNHNQIESLGEYAAFLPSDPHENDRLIKGIWSNLKFVSIINITCWIIYKSIANISWLTPLFYTLPLVSLFMTIYKLFFKNSYSSPGQIRIFTTIKRIIKGNINSQTMRTNDILISDSLVSYSRVINDLGLVIWNYWFDSNIGYNYKFESMILSIPTCIRIKQCWYEYKLTGKTQHLFNLIKYSTGLGPLLINVLLKRMLLNATEQEKTSGELLLKLNHLNNWLYFALAVNSTYSFIWDIKMDWHLELFDGLFSVVSGKKTSHSVVSNYRFQILRKQLALPRSIYYIAIIIDFILRYIWILKLFIINEELKKEKIKFIYIFSTFLFGYDAYSLGYALIETLEIFRRWIWCFIKLESDWVELYNDQDLSNQDIELETRLPKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDQ7</accession>
    <name>C4YDQ7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YDQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00654"/>
    <dbReference type="HOGENOM" id="CLU_1959260_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="128" mass="13628" checksum="E04734B8079E31FE" modified="2009-07-28" version="1">MNQKKMPANTSADSSPNDCSFHSPASPLQAINPPPVNSISAPAAVAAADPMNAPPAGQTPTSPSATPKPNPIPTATIQLSDSGSNLEFQIQRIIEREIQKSCCKSNECNVTYYCTKFYCFVSLECCFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDT9</accession>
    <name>C4YDT9_CANAW</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
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    </organism>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YDT9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00687"/>
    <dbReference type="HOGENOM" id="CLU_1927291_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="131" mass="15524" checksum="E69EA0DA9CC739AE" modified="2009-07-28" version="1">MNVQIISGFLVLFSFIFGQTQFLRQDSFAIEDISIRKRSTMLVFNYFSVLISVEFFISGFFFFFGLLFLRVHYIIRIIRAKTTSNHIAAFRVQVPAASFIRLLIIKVAFLFKQLEWSDYLFTTKVFWNVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDU1</accession>
    <name>C4YDU1_CANAW</name>
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            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_00689</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDU1"/>
    <dbReference type="PaxDb" id="5476-C4YDU1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00689"/>
    <dbReference type="HOGENOM" id="CLU_011639_2_0_1"/>
    <dbReference type="OMA" id="DEFELWG"/>
    <dbReference type="OrthoDB" id="296793at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048685">
        <property type="entry name" value="COG3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048320">
        <property type="entry name" value="COG3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007265">
        <property type="entry name" value="COG_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302:SF8">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20671">
        <property type="entry name" value="COG3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04136">
        <property type="entry name" value="COG3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 N-terminal" evidence="10">
        <location>
            <begin position="120"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 C-terminal" evidence="11">
        <location>
            <begin position="292"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="797"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="803"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ42477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="839" mass="96520" checksum="BC58FECB428DA2F6" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDV5</accession>
    <name>C4YDV5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_00703</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDV5"/>
    <dbReference type="SMR" id="C4YDV5"/>
    <dbReference type="PaxDb" id="5476-C4YDV5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00703"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_0_1"/>
    <dbReference type="OMA" id="CLSIPIM"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF10">
        <property type="entry name" value="S-ADENOSYLMETHIONINE PERMEASE SAM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="497"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="534"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="12">
        <location>
            <begin position="107"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ42491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="607" mass="66478" checksum="88A2E3251053A030" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDX2</accession>
    <name>C4YDX2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 2 subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_00720</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDX2"/>
    <dbReference type="SMR" id="C4YDX2"/>
    <dbReference type="PaxDb" id="5476-C4YDX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00720"/>
    <dbReference type="HOGENOM" id="CLU_033458_0_1_1"/>
    <dbReference type="OMA" id="DVNEHQR"/>
    <dbReference type="OrthoDB" id="1685042at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1130:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000015">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.190:FF:000002">
        <property type="entry name" value="Translation initiation factor 2, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="10">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ42508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="300" mass="33882" checksum="E088A6F6B4B9071E" modified="2010-10-05" version="1">MSTTNCRFYENKYPEVDEVVMVNVQEIAEMGAYVKLLEYDNIEGMVLLSELSRRRIRSIQKLIRVGKNEVAVVLRVDKEKGYIDLSKKVVSAEDIVKCDERYNKSKAVHSILRHCAEKFNIPLERLYETIGWPLSRKYGHAYDAFKISITDPSVFDSVDVPSKDVLEELKLYISRRLTPQAINIRADVDVSCFSYEGIDAIKEALKAAESVSTSQMQVKAKLVAAPLYFITVQALDKNEGVKLLEKAIEKITESIEASGGNCKVSMPPKAVSANEDAELERMLQRREAEDKDSSDEEDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YE16</accession>
    <name>C4YE16_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_00766</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YE16"/>
    <dbReference type="PaxDb" id="5476-C4YE16"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00766"/>
    <dbReference type="HOGENOM" id="CLU_072439_6_3_1"/>
    <dbReference type="OMA" id="NINACFY"/>
    <dbReference type="OrthoDB" id="1677536at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044391">
        <property type="term" value="C:ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000018">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ42552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="92" mass="9725" checksum="7B0E1424F9F74BDE" modified="2009-07-28" version="1">MKVKADRDESSPYAAMLAAQDVAAKCKEVGITAVHIKLRATGGTKTKTPGPGGQSALRALARSGLRIGRIEDVTPVPSDSTRRKGGRRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YE48</accession>
    <name>C4YE48_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_00801</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YE48"/>
    <dbReference type="PaxDb" id="5476-C4YE48"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00801"/>
    <dbReference type="HOGENOM" id="CLU_108696_0_0_1"/>
    <dbReference type="OMA" id="IRCYSAF"/>
    <dbReference type="OrthoDB" id="448946at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000081">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002150">
        <property type="entry name" value="PRK00982.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 13" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="14">
        <location>
            <begin position="64"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ42584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="144" mass="16173" checksum="E9734E1725699C67" modified="2010-10-05" version="1">MFRTTLLKSLRASVSKPSMVKTIQSSSRSLFTITTITNNKNVTPLTSSMNFIRCYSAFPELTRDIAKERIIELLEGYDKVDQSKGEITEQNSFTSDLGLDSLDVVEVIMELEHEFNIQIPDNEADSLKTVGQTIDYILAQPDSC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-10-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YE90</accession>
    <name>GATB_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial</fullName>
            <shortName evidence="1">Glu-AdT subunit B</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">PET112</name>
        <name type="ORF">CAWG_00844</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Subunit of the heterotrimeric GatFAB amidotransferase (AdT) complex, composed of A, B and F subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">This protein may be expected to contain an N-terminal transit peptide but none has been predicted.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YE90"/>
    <dbReference type="SMR" id="C4YE90"/>
    <dbReference type="PaxDb" id="5476-C4YE90"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00844"/>
    <dbReference type="HOGENOM" id="CLU_019240_4_0_1"/>
    <dbReference type="OMA" id="ARKWWMG"/>
    <dbReference type="OrthoDB" id="1722066at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="GatB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004012">
        <property type="entry name" value="PRK05477.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="GLUTAMYL-TRNA GLN AMIDOTRANSFERASE SUBUNIT B MITOCHONDRIAL AND PROKARYOTIC PET112-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000413249" description="Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial">
        <location>
            <begin position="1"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03147"/>
        </source>
    </evidence>
    <sequence length="488" mass="55715" checksum="1EA6498816A67076" modified="2009-07-28" version="1">MSQISMFVRKLHKFSYNPNYKFKCGLEIHTQLKTKYKLFSLSPTSYNEPPNTKLSYFDVGLPGTQPLLNPEALLLALKASVALNCDIQSYSSFDRKHYFYADQPLGYQITQHYYPLAKNGYVQLNKFDDMPDKVISLEQVQLEQDTGKTVNYDDRINVDLNRANTPLIEVVTKPDFENIDQVQAFVRKYQLLVSHLDICTGDLETGAIRVDANISVNNNPRVEIKNLGSSGEIVDALKYEYNRQVTLLQNNGKIIQETRGWNGIATESLRKKENAVDYRYVPDSELPVIRLDKNIQAQLQNTLDELPDSVLDRLTKEPYNLQLAHARNLLFQPEILDYYENIFGRIRDANKWFFHELLAAFAKSDVEFQVDIVSPDMLVDIVSSVEKNEISLTGARIILKHIIRNKSTKTLPQLIKELDIGKPEASAELEEAINEICQQIINTNADVVEKIARGHTNALQVLIGQAMKATKGKVHAKEFRSKFMELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEK5</accession>
    <name>C4YEK5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylglucosamine-induced protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_00962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEK5"/>
    <dbReference type="PaxDb" id="5476-C4YEK5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00962"/>
    <dbReference type="HOGENOM" id="CLU_075862_2_0_1"/>
    <dbReference type="OMA" id="YHDWEDL"/>
    <dbReference type="OrthoDB" id="10053431at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022036">
        <property type="entry name" value="DUF3605"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020:SF2">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12239">
        <property type="entry name" value="DUF3605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ42741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="30124" checksum="9FBE31460BEA69EC" modified="2009-07-28" version="1">MNPATIITNFNNSQLQTPPTSPVSFDKYYAYYNIQLEQSKLMPQPSKIKNGDPFTWSDIQFIIKSNQLEIFARSRQQTIKYHKFKQWLKDNKLSINDYLLDYELHWKESELREQQHELVSDKEYSIDYPEDLIFHNPNDISILYNKFPYYFEPNVKHICIWSKLKIPVDKNSEVGDISVMTKKLINRYLEKTFVAKGISWDQIVWFKNWLSLQSVRSISHIHVILKDVDDKFVDELISGGSGEVLTLDDYRNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEM7</accession>
    <name>C4YEM7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_00984</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEM7"/>
    <dbReference type="PaxDb" id="5476-C4YEM7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00984"/>
    <dbReference type="HOGENOM" id="CLU_044487_0_0_1"/>
    <dbReference type="OMA" id="FMLGNKR"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="73"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ42763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="406" mass="46535" checksum="E7E398CC416CE613" modified="2009-07-28" version="1">MASRELTPIPTGATTGTGTAATNGSNTSTPLMPSIVQISRPFFTHKEISYLHNQTIPESLKPHYTNIKNNVFQFLFQIIKQLKFPLRVLATAMNYYQRYYLFNKFETNNNSGGGGNGGNGGATFDFSDDPHTIAITCLFLASKVEDCIKRLKDIQTIANKLRDQNIDENKIIESSGLSYIDHQRKHILSIEYKLLQIIKFDFNNGPITIRTSVDNLIIQFCKNMKINYKLSMLAWLINFDIMSTPLSLVVPPHCIALAIIIISLNLNPIEIKLNHEPQEEEEEGNYLSAQEILQSLDSDDFKCPEVLVNEAIIYILDYYIHQYQISILNVYLPLIDSESGKEQGYKFMKLKSEFNEIKIMDETSCSKLLNETDEYLNKWDYTISSKGSTRFMLSNKRRRFNKELEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF55</accession>
    <name>C4YF55_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_01166</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF55"/>
    <dbReference type="PaxDb" id="5476-C4YF55"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01166"/>
    <dbReference type="HOGENOM" id="CLU_007383_1_14_1"/>
    <dbReference type="OMA" id="WNEKPNL"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000304">
        <property type="entry name" value="UDP-glucose 4,6-dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="11"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ42941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="320" mass="36469" checksum="C4DBF1FC5F1EA62E" modified="2009-07-28" version="1">MTVSFDKRIVVSGGAGFIGIHFLCYMVKKYPNFHFTCIDKLNYASNATEIENLKSFSNFEFVHLDLSDNLEYLLKITKNTTDMINFAAESSVDRSFEDPVYFTKNNILATQNLLECHRLNPSIGYFLHISTDEVYGDVYEGDNKENAVMNPTNPYSASKAAIDLIIKSYQYSYKLPITILRPNNVYGPLQYPEKIIPLTIQCINEKKPIPVHGKGTNKRKYLYVLDLVLAIETVWIKNPMTTVNQIYNIGGTDELDNLSLIKLIMEIFGPGEIQFIKDRNYNDTNYSIDTTKIHNLGWSPKISLVQGLQLCKQSLDSPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF76</accession>
    <name>C4YF76_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_01188</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF76"/>
    <dbReference type="PaxDb" id="5476-C4YF76"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01188"/>
    <dbReference type="HOGENOM" id="CLU_000604_57_4_1"/>
    <dbReference type="OMA" id="AYFWYAF"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF119">
        <property type="entry name" value="ROA1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="618"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1063"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1108"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1135"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1172"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1249"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="18"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="692"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ42962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1274" mass="143848" checksum="8AE07AFA51F4CCD1" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFS1</accession>
    <name>C4YFS1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycoside hydrolase family 5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_00047</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFS1"/>
    <dbReference type="PaxDb" id="5476-C4YFS1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00047"/>
    <dbReference type="HOGENOM" id="CLU_004624_8_2_1"/>
    <dbReference type="OMA" id="KWYDEVL"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046557">
        <property type="term" value="F:glucan endo-1,6-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000100">
        <property type="entry name" value="Glycoside hydrolase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF43">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="7">
        <location>
            <begin position="88"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ41860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="502" mass="56953" checksum="3B0C7990FFEB5EA7" modified="2009-07-28" version="1">MQAAFSKLKLKSKASDIPQADSASTSGKPPSTKQIYQSRQNFGVNFGACFVLEKWIYHELFSETNGDAELDAVSSLFKKLGEYDTRSRFENHWKGYVNDDDWKWLSEHHVNSIRLPIGYWEVDGGAYTSGTNFDKYKGVYKNAWKIIKDDFIKKALDHKISVLVDIHGLPGGANNSGHSGESGAGGKFWKDEKKQIAIAKMMGWIANDLKSFDNIAGIQVVNEAEFSDPAKKQSTYYSACITEIRKSDKSVPIVISDGWWADQWVKWVQEKQGSDGYIGVVLDEHVYRCFSDDDKKKKPQQIIDDLQGDVLTNLNDNGKGVDFIVGEYSCVLDQQSWDNDKNADRDDLVKKFGQRQSEEFAQKTSGSYFWTFKFQSGNGGEWDFKTMTDKGALVPPPIPSNQPSDDKFEEALNNAYNGHVDFWKNEHPDGKFEHDNFKEGFTIAWKDADAFAQFDGSRIGRKEAWKRSRLQEFASSKGKSDFLWEWEQGFDQGLEGFYSAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFW4</accession>
    <name>C4YFW4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_01352</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFW4"/>
    <dbReference type="PaxDb" id="5476-C4YFW4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01352"/>
    <dbReference type="HOGENOM" id="CLU_007339_1_0_1"/>
    <dbReference type="OMA" id="YKFAEAK"/>
    <dbReference type="OrthoDB" id="10261632at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.110:FF:000009">
        <property type="entry name" value="Vps53p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="7">
        <location>
            <begin position="6"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="8">
        <location>
            <begin position="541"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ43115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="699" mass="80772" checksum="E3A4315D75D582A6" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG10</accession>
    <name>C4YG10_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_00123</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YG10"/>
    <dbReference type="PaxDb" id="5476-C4YG10"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00123"/>
    <dbReference type="HOGENOM" id="CLU_032651_0_0_1"/>
    <dbReference type="OMA" id="RLVMMEL"/>
    <dbReference type="OrthoDB" id="5591297at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285:SF0">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ41934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="298" mass="34291" checksum="815ECE022B3911F9" modified="2010-10-05" version="1">MSKGRFLKPLQEFLTSKSDFSIIYNTSTTGSTSSFINPTTQRVCILDSSFNPPHLGHYALIEESLTKNYDNIPITNKVVLLLLSVKNADKLHPKPESFDKRLDMMYLMANDLSKKYPVNIAIGLTNHAKFVDKSLSVLNYIKETQNHHQERNLIKLTFLVGFDTLIRIFDPKYYLPDKLSNSLENFMKNTDLFCLTRLDNSFSQLEQSKYIDDIKRGDHEEIPSHWSDNIYLLPPKKEIEINQRGGEINQEIDVATISSSSIRKQIEIGDHPDGKTWKSQVLPDIANYIIKEDLYKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG63</accession>
    <name>C4YG63_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YG63"/>
    <dbReference type="PaxDb" id="5476-C4YG63"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00181"/>
    <dbReference type="HOGENOM" id="CLU_088025_0_0_1"/>
    <dbReference type="OMA" id="LHKGPRV"/>
    <dbReference type="OrthoDB" id="2281895at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000052">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein YmL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040030">
        <property type="entry name" value="Ribosomal_mL57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L15, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="73"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ41987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="220" mass="24628" checksum="7D4E782CF3542448" modified="2009-07-28" version="1">MIGNIRQLSSRITGQQFTIFTRSIYLHKGPRVEGLKRDPEAAFINPKGIKYGLNETNISHIKSFLGDKYNIPDEIALQVITHKSFGNGIKPYNEKLAAMGSKLLSLYFAKYVTNQPCKHDNGVEGKNLDVLGSPMSRELPSLKTAAIFAKSNNINEIMFWHTRNSTLGFESSGELKVSGELLFSLVGAVNFYHGKDKAEQFITEKLVDQFEKISAQNVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGA2</accession>
    <name>C4YGA2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bul1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_00223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGA2"/>
    <dbReference type="PaxDb" id="5476-C4YGA2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00223"/>
    <dbReference type="HOGENOM" id="CLU_022027_0_0_1"/>
    <dbReference type="OMA" id="HINLNIV"/>
    <dbReference type="OrthoDB" id="2283785at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039634">
        <property type="entry name" value="Bul1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022794">
        <property type="entry name" value="Bul1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007519">
        <property type="entry name" value="Bul1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904:SF1">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04426">
        <property type="entry name" value="Bul1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04425">
        <property type="entry name" value="Bul1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bul1 N-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Bul1 C-terminal" evidence="2">
        <location>
            <begin position="527"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ42026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="722" mass="82918" checksum="5895570B5180289A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGI6</accession>
    <name>C4YGI6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_03163</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
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        <property type="protein sequence ID" value="EEQ44868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YGI6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03163"/>
    <dbReference type="HOGENOM" id="CLU_021752_0_0_1"/>
    <dbReference type="OMA" id="EKMAAVW"/>
    <dbReference type="OrthoDB" id="271164at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="project" value="GOC"/>
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        <property type="term" value="C:endosome"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:phosphatidylinositol binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:protein retention in Golgi apparatus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="BAR_Vps5p"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PX_Vps5p"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative Sorting nexin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000022">
        <property type="entry name" value="Sorting nexin 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037868">
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    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="270"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="48"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="179"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="568"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ44868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="672" mass="76310" checksum="A549AB0E89F1A1CE" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGJ6</accession>
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        <recommendedName>
            <fullName evidence="7">LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">CAWG_03174</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
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            <taxon>Saccharomycotina</taxon>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407:SF28">
        <property type="entry name" value="RIBITOL-5-PHOSPHATE TRANSFERASE FKTN"/>
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        <property type="entry name" value="LicD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="7">
        <location>
            <begin position="606"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="7">
        <location>
            <begin position="727"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="299"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="313"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ44878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="996" mass="116128" checksum="A19B78CE0218AC78" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGR2</accession>
    <name>C4YGR2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Trafficking protein particle complex II-specific subunit 130</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_03244</name>
    </gene>
    <organism evidence="11 12">
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        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="75"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="474"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ45083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="513" mass="57851" checksum="355BA1130AF7EDFD" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHD6</accession>
    <name>C4YHD6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 21">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="20">CPR</shortName>
            <shortName evidence="20">P450R</shortName>
            <ecNumber evidence="20 21">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CAWG_03482</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 26">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="20">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="20">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Endoplasmic reticulum membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Mitochondrion outer membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Cell membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20 21">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="20 21"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHD6"/>
    <dbReference type="SMR" id="C4YHD6"/>
    <dbReference type="PaxDb" id="5476-C4YHD6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03482"/>
    <dbReference type="HOGENOM" id="CLU_001570_17_3_1"/>
    <dbReference type="OMA" id="QKRYQRD"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000009">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000100">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000075">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000018">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03212">
        <property type="entry name" value="NCPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 20" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 20 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 20" id="KW-0274">FAD</keyword>
    <keyword evidence="3 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 20" id="KW-0288">FMN</keyword>
    <keyword evidence="2 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 20 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 20" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9 20 21" id="KW-0521">NADP</keyword>
    <keyword evidence="12 20 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 20" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="18 20" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 20" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="17 20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="22">
        <location>
            <begin position="60"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="23">
        <location>
            <begin position="264"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="66"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="117"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="439"/>
            <end position="442"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="457"/>
            <end position="459"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="473"/>
            <end position="476"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="537"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="599"/>
            <end position="600"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="606"/>
            <end position="610"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="642"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="680"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR000208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EEQ45168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="680" mass="76642" checksum="4A9D2A4910BD169F" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHD7</accession>
    <name>C4YHD7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MAGE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_03483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHD7"/>
    <dbReference type="PaxDb" id="5476-C4YHD7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03483"/>
    <dbReference type="HOGENOM" id="CLU_049350_0_0_1"/>
    <dbReference type="OMA" id="KFFLPKY"/>
    <dbReference type="OrthoDB" id="205198at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1200">
        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041898">
        <property type="entry name" value="MAGE_WH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF14">
        <property type="entry name" value="NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="2">
        <location>
            <begin position="60"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ45169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="339" mass="38319" checksum="424B67C35F21FBDF" modified="2009-07-28" version="1">MSSLKRKIPLDEIEDFIAEEEEEEEQNDDGSYEEDNEFVGPSGTATPLDESEIQHVVNQVVRLFLSRELNGRTTRPDVIRKHIKHNLGRKITTEKLIQQANIILTEVYGLKIEEVPTIKREDKKSSKSRKVTSDKNPYIVTSSLSSKSRAILGELWNKNLAKNVKKIDIGGNKFFLPKYSITSVPGSHYELVKTGIMLVIISHIILNENHVSESALLKTLHKFGISSNLNVKNSNFNLNSQELLKELVNKDYILKNAIKGRTESENIFDYSIGQRSLVEFSPQGVFDYIKVIYGNKFDSTIAERALVTIERAYGVALNNTEENNEREGSTEANSQEGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHI6</accession>
    <name>C4YHI6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_03533</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHI6"/>
    <dbReference type="PaxDb" id="5476-C4YHI6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03533"/>
    <dbReference type="HOGENOM" id="CLU_009281_10_1_1"/>
    <dbReference type="OMA" id="HKAMWHE"/>
    <dbReference type="OrthoDB" id="203824at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019150">
        <property type="term" value="F:D-ribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019321">
        <property type="term" value="P:pentose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07782">
        <property type="entry name" value="ASKHA_NBD_FGGY_D-RBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006003">
        <property type="entry name" value="FGGY_RbtK-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01315">
        <property type="entry name" value="5C_CHO_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435:SF4">
        <property type="entry name" value="FGGY CARBOHYDRATE KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435">
        <property type="entry name" value="RIBULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="5">
        <location>
            <begin position="30"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="6">
        <location>
            <begin position="328"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="555"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="617"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="623"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="644"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ45218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="742" mass="81065" checksum="C53DC317A53C32F9" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHK5</accession>
    <name>C4YHK5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_03552</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YHK5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03552"/>
    <dbReference type="HOGENOM" id="CLU_002414_2_1_1"/>
    <dbReference type="OMA" id="PMTKFKL"/>
    <dbReference type="OrthoDB" id="6109at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002440">
        <property type="entry name" value="Subunit of the mRNA cleavage and polyadenylation factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="6">
        <location>
            <begin position="13"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="6">
        <location>
            <begin position="236"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="7">
        <location>
            <begin position="558"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="5">
        <location>
            <begin position="1026"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="160"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="438"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="725"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ45237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1423" mass="162089" checksum="36A2E699DEA9F81B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHM4</accession>
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        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_03572</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
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                <person name="Staggs R."/>
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                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF1">
        <property type="entry name" value="ACTIVATOR OF STRESS GENES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="86"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="162"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ45256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="805" mass="92376" checksum="FA055A4257BC566D" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIE1</accession>
    <name>C4YIE1_CANAW</name>
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        <recommendedName>
            <fullName evidence="16">Farnesyl pyrophosphate synthase</fullName>
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        <alternativeName>
            <fullName evidence="15">(2E,6E)-farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Dimethylallyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Geranyltranstransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_04214</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.1" evidence="6"/>
    <dbReference type="EC" id="2.5.1.10" evidence="5"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIE1"/>
    <dbReference type="SMR" id="C4YIE1"/>
    <dbReference type="PaxDb" id="5476-C4YIE1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04214"/>
    <dbReference type="HOGENOM" id="CLU_028376_1_0_1"/>
    <dbReference type="OMA" id="CSWVVNQ"/>
    <dbReference type="OrthoDB" id="10257492at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000006">
        <property type="entry name" value="Farnesyl pyrophosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01017">
        <property type="entry name" value="Polyprenyl_Transferase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ45876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="351" mass="40712" checksum="C52EB77D6E5FBAF5" modified="2009-07-28" version="1">MSDKLAARERFLDVFEDLVEELKQILVSYNMPQEAIEWFVRSLNYNTPGGKLNRGLSVVDTFAILNNTTSDKLNDTEYKKVALLGWAIELLQAYFLVADDMMDQSKTRRGQPCWYLVEGVNNIAINDSFMLEGAIYILLKKHFRQDPYYVDLLDLFHEVTFQTELGQLLDLITADEEIVDLDKFSLEKHSFIVIFKTAYYSFYLPVALAMYMSGINDEKDLKQVRDILIPLGEYFQIQDDYLDCFGTPEQIGKIGTDIKDNKCSWVINQALLIATPEQRQLLDNNYGKKDDESEQKCKDLFKQLGIEKIYHDYEESIVAKLRKQIDQIDESRGLKKDVLTAFLGKVYKRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIN4</accession>
    <name>C4YIN4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Myb-like DNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_04310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIN4"/>
    <dbReference type="PaxDb" id="5476-C4YIN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04310"/>
    <dbReference type="HOGENOM" id="CLU_426985_0_0_1"/>
    <dbReference type="OMA" id="ASNWVKI"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050891">
        <property type="term" value="P:multicellular organismal-level water homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901002">
        <property type="term" value="P:positive regulation of response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902584">
        <property type="term" value="P:positive regulation of response to water deprivation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902806">
        <property type="term" value="P:regulation of cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032875">
        <property type="term" value="P:regulation of DNA endoreduplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000037">
        <property type="term" value="P:regulation of stomatal complex patterning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033993">
        <property type="term" value="P:response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000589">
        <property type="entry name" value="AEL176Cp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000355">
        <property type="entry name" value="Transcription factor MYB124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF25">
        <property type="entry name" value="MYB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="111"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="111"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="7">
        <location>
            <begin position="114"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="163"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="167"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="224"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="471"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="556"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="505"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="571"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ45969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="607" mass="67600" checksum="88EE6D0E49F94739" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIS0</accession>
    <name>C4YIS0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ46005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIS0"/>
    <dbReference type="PaxDb" id="5476-C4YIS0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04347"/>
    <dbReference type="HOGENOM" id="CLU_572363_0_0_1"/>
    <dbReference type="OMA" id="LSILMCE"/>
    <dbReference type="OrthoDB" id="4093184at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="477" mass="54479" checksum="8C1FA055E4DA1C3B" modified="2009-07-28" version="1">MSSESLPISSSSSSSSSNRKKANESVLEEAIVRSSIDTIDLITPKKLSNLSIKTTADDLQSNIEGYQEFLFNANTLFGERPLADYQYLWLETIYRLTFTLVKLKKSFSQLYLHAQPYEIESIGPKAIVLNAKLMQATEELSILMCEFFNNALSIVVAFENRVQSLIGQCLKLLLLEEMEDDRFDHISNAALQQIQVYLINHKVGIEILIRFSETVYKLGKSPLILPLLQEFDPELPMNLIASNAINLVDVMNFYRYVSFNLVSLSVNDKKYAKLAEIYFRILLAFPNLNLKLYVKDEDEKGMFRDKRDEFIINLSERQELSLMYVLNYLLAVGSLRKLLESSQLYQKELSFLVNSVSLSLSKDIDKLASQTTSTRSSMVSIPQYNMEIERKLEIEKKLASSKYKYSSLSSVIFNGSYKEKLRLVVNFGESLLAPNLLVKKLKNKSIDNNDSYVESNKVVERLIHAMNNIEDDLLAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ12</accession>
    <name>C4YJ12_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_03824</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ12"/>
    <dbReference type="PaxDb" id="5476-C4YJ12"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03824"/>
    <dbReference type="HOGENOM" id="CLU_011815_0_2_1"/>
    <dbReference type="OMA" id="LDNKSMY"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF219">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="17">
        <location>
            <begin position="33"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="105"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="13">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ45496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="352" mass="40733" checksum="5B479236C2B4F5BF" modified="2009-07-28" version="1">MSATTTTNIIKASPKRKTKTDTKDQDNSYYGQLNKRNINKVTFGKYEFPTWYGNAAYFYPHDLSHSSLGYEYANKVASEGSIARKIHKKDIFDENLHEFWLDHLFVCEYCFKYTSNETILNQHVTACTYNRKRPSKGKLLYHDQANGYIIREVRGFQDPLFCQNLCLFGKLFLDDKSVYYNIDHFDFYIVFGKDDSSYIPMGFFSKEVLSYDNDNNLACICVFPPFQRRHLGSLLIEFSYQLAAVTPGQLKSSGPEFPLSPYGKVTYLRFWSKRLATKIHELQGSFTLSQLSKETGFRKEDILLTLEYMQILVTDDLGNVTLSLERLENWCSQNKVVPGVDINILNSECLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ13</accession>
    <name>C4YJ13_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_03825</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ13"/>
    <dbReference type="SMR" id="C4YJ13"/>
    <dbReference type="PaxDb" id="5476-C4YJ13"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03825"/>
    <dbReference type="HOGENOM" id="CLU_014831_4_1_1"/>
    <dbReference type="OMA" id="WSKNTDE"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000025">
        <property type="entry name" value="FIZZY-related 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="10">
        <location>
            <begin position="284"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="329"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="412"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="542"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="137"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ45497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="597" mass="65953" checksum="17F4C76532314C56" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ30</accession>
    <name>C4YJ30_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">allantoicase</fullName>
            <ecNumber evidence="3">3.5.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_03842</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Utilization of purines as secondary nitrogen sources, when primary sources are limiting.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>allantoate + H2O = (S)-ureidoglycolate + urea</text>
            <dbReference type="Rhea" id="RHEA:11016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="3.5.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Nitrogen metabolism; (S)-allantoin degradation; (S)-ureidoglycolate from allantoate (aminidohydrolase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the allantoicase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.4" evidence="3"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ30"/>
    <dbReference type="SMR" id="C4YJ30"/>
    <dbReference type="PaxDb" id="5476-C4YJ30"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03842"/>
    <dbReference type="HOGENOM" id="CLU_038797_0_0_1"/>
    <dbReference type="OMA" id="MDDGWET"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000078">
        <property type="entry name" value="DAL2p Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000059">
        <property type="entry name" value="Probable allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00813">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02961">
        <property type="entry name" value="allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045">
        <property type="entry name" value="ALLANTOICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045:SF3">
        <property type="entry name" value="INACTIVE ALLANTOICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016516">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Allantoicase" evidence="8">
        <location>
            <begin position="27"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Allantoicase" evidence="8">
        <location>
            <begin position="201"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ45514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="342" mass="38204" checksum="E8CFB48D47CC4740" modified="2010-10-05" version="1">MTKILSQDDFQKQIVSQYTDVIGEKLGGKVLSFSDQWFADAENLIKPKPPIRDATRFTYAGAWYDGWETRRHNEAEADWVIFKLGVSSAKLIACEVDTAFFNGNHAPHISVEALQNFDASDENLQNVKEEDWEEVIAKVECGPSQKHFFSRGSLTNKNYTHARLRMYPDGGIARFRLYGQVIPVTDQSSSSVTDFASVQNGGVAIKFSDQHFGTADNLLLPGRGHDMSDGWETKRSREPGHTDWVIIRLGAPAKLSEIVVDTAHFRGNFPQKVNVKGINVDEESKIEANSDAWEVVVDDSKTSADKEHAFKVKDNSKVYSHIKLTIIPDGGVKRIRAFGVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJD8</accession>
    <name>C4YJD8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Prp39p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_03951</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
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                <person name="Forche A."/>
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                <person name="Arnaud M.B."/>
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                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
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                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
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                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
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                <person name="Quinn J."/>
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                <person name="Sherlock G."/>
                <person name="Shah P."/>
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                <person name="Staggs R."/>
                <person name="Stansfield I."/>
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                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
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                <person name="Lorenz M.C."/>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <text evidence="6">Belongs to the PRP39 family.</text>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
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        <property type="entry name" value="HAT"/>
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    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR17204">
        <property type="entry name" value="PRE-MRNA PROCESSING PROTEIN PRP39-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204:SF5">
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="EEQ45622.1"/>
        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="638" mass="75386" checksum="B7BF5148C150887E" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJF9</accession>
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        <name type="scientific">Candida albicans (strain WO-1)</name>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
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                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
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                <person name="Skrzypek M.S."/>
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                <person name="Staggs R."/>
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                <person name="Srikantha T."/>
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                <person name="Berriman M."/>
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                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="584"/>
        </location>
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            <end position="1119"/>
        </location>
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    </feature>
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    </feature>
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    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="1093"/>
            <end position="1111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ45643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1151" mass="127750" checksum="1FD21CB0982A039C" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJI9</accession>
    <name>C4YJI9_CANAW</name>
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        <recommendedName>
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    </protein>
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    </gene>
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            <taxon>Pichiomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Sakthikumar S."/>
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                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
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                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
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                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
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                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
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                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
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                <person name="Berriman M."/>
                <person name="Heitman J."/>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. RKM5 family.</text>
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    </dbReference>
    <dbReference type="GO" id="GO:0032991">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF109">
        <property type="entry name" value="RIBOSOMAL LYSINE N-METHYLTRANSFERASE 5"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
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    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ45673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="280" mass="31635" checksum="A6C59C22188531A2" modified="2009-07-28" version="1">MCSWTAVTEQLEPIQHNNIEDHIFELYSERQLQNNLGYVDRTANEITVTLPKNKIDLNITQSLTQLANQKSNASSTGFICWQSSIFFIDWLISPECPFQLSKTFTILELGSGSAGICASILSSKVQHFIATDQKHVLKLLRQNIENNVSNFTSTSNSKNSDGNPHKLIDVVEFDWENIEMGKFNIQSLNMQKEHPDIIIACDTIYNEYLIPHFVQSLNALMAGNQQTVALVAIQLRDSITFEVFVTEVVQSGELSLYNVPDHLLSDDLKNGYVVYCILKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJP8</accession>
    <name>C4YJP8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-oxoprolinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_04066</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="C4YJP8"/>
    <dbReference type="PaxDb" id="5476-C4YJP8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04066"/>
    <dbReference type="HOGENOM" id="CLU_002157_0_1_1"/>
    <dbReference type="OMA" id="PVVEFYM"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="10"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="242"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="5">
        <location>
            <begin position="669"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="744"/>
            <end position="1271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ45732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1303" mass="141965" checksum="6B6BAD39AE8E8800" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJQ5</accession>
    <name>C4YJQ5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6B homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_04073</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJQ5"/>
    <dbReference type="PaxDb" id="5476-C4YJQ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04073"/>
    <dbReference type="HOGENOM" id="CLU_000688_2_0_1"/>
    <dbReference type="OMA" id="QDIGGMD"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000020">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000046">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="188"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="34"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ45739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="411" mass="45897" checksum="3638B4F0ADDA48B6" modified="2009-07-28" version="1">MEDPVSLDNVNSVLSKLNNVSATNSNETDVYLKLKKLEKELDLLLLQEEYIKDEQRHLKRELVRAQEEVKRIKSVPLVIGQFLEPIDENTGIVSSTTGSNYVVRILSTLDRELLKASSSVALHRHSNALVDILPPEADSSISIVGEDQKPDITYADVGGLDMQKQEIKEAVELPLTQGDLYSQIGIDPPRGVLLYGPPGTGKTMLVKAVANSTTASFIRINGSEFVQKYLGEGPRMVRDVFRLARENSPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQTSTVKVIMATNRADTLDPALLRPGRLDRKIEFPSLKDRRERRLIFSTIASKMSLAPEADLDSLIIRNDPLSGAVIAAIMQEAGLRAVRKNRYMILQSDLEEAYTSQVKTGTEHDKFDFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJT8</accession>
    <name>C4YJT8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">SED5-binding protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_04108</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJT8"/>
    <dbReference type="PaxDb" id="5476-C4YJT8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04108"/>
    <dbReference type="HOGENOM" id="CLU_004589_1_0_1"/>
    <dbReference type="OMA" id="INPFMTF"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="8">
        <location>
            <begin position="264"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="9">
        <location>
            <begin position="344"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="11">
        <location>
            <begin position="603"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="10">
        <location>
            <begin position="705"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ45772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1011" mass="113786" checksum="6FE7EA9FE944BF61" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKH8</accession>
    <name>C4YKH8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKH8"/>
    <dbReference type="PaxDb" id="5476-C4YKH8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05982"/>
    <dbReference type="HOGENOM" id="CLU_305017_0_0_1"/>
    <dbReference type="OrthoDB" id="10414376at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946721" evidence="2">
        <location>
            <begin position="23"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="738"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="482"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="658"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="738"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ47407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="973" mass="105536" checksum="969CFF565B5F5EF3" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKY9</accession>
    <name>C4YKY9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_01502</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKY9"/>
    <dbReference type="PaxDb" id="5476-C4YKY9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01502"/>
    <dbReference type="HOGENOM" id="CLU_013173_4_2_1"/>
    <dbReference type="OMA" id="TKRPEYR"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF565">
        <property type="entry name" value="AT28366P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="12">
        <location>
            <begin position="23"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="56"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ43270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="340" mass="38132" checksum="8FB4B737A463B5B2" modified="2009-07-28" version="1">MGQILSQPVVEKHSDEHKDKYLAYGISCMQGWRINMEDAHATILNLYDLPLKKSLSSNSEQDEDEEDEEEEADSQDSTTTNTTKSQQQQNQKEDLQQNNDKQNSQQDIKDGDNDTQMSDSDENHHHAAPQQQHIAFFGVYDGHGGEKAAIFTGEKLHHLIKETKEFKQKDYINALKQGFLNCDQEILKDFYMRDDDSGCAATSAIITPDLIVCGNAGDSRTIMSTNGFAKALSFDHKPSNEGEKARICAAGGYVDMGRVNGNLALSRGIGDFDFKKNVDLPAEEQIVTCYPDVIQHNIDYKSDEFVVLACDGIWDCLTSQKCVECVRRGIYERKSLSIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL38</accession>
    <name>C4YL38_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphomutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_01553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL38"/>
    <dbReference type="PaxDb" id="5476-C4YL38"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01553"/>
    <dbReference type="HOGENOM" id="CLU_039184_0_2_1"/>
    <dbReference type="OMA" id="LHLCHKR"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="35864" checksum="12CC81C4B0D12471" modified="2009-07-28" version="1">MSLLIPTPRDRHDAHGDLEEDNAYYNLLTKEQNSTNNRYIWKFEPVKGFFKQTDEQTDDMAFRYTEQKLGRLDDWEKIVADLQQLNRDSPDNEIYKLIFLARHGQAKSNVASQKYSKEEWMRKWRFLGTDGELTWGPDADLTELGLKQAAENHQCWKQQLLEGAPYPKRFYVSPLQRSIKTHNITWPNTKPIVLENLRETIGLHLCHKRSNKSSLKEKFPNLVFEDGFTEEDLLFDKYLPRKEHLHEQFLRINGVLQDIFNSDEEDILCITSHAGTIRAFITVLGHRKFTIPTGGMIPVVIKATRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL62</accession>
    <name>C4YL62_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_01577</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL62"/>
    <dbReference type="PaxDb" id="5476-C4YL62"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01577"/>
    <dbReference type="HOGENOM" id="CLU_003181_2_0_1"/>
    <dbReference type="OMA" id="TDWVHDT"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000030">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF3">
        <property type="entry name" value="CLC CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0868">Chloride</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="561"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="592"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ43343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="859" mass="96584" checksum="24BEA11E0F165A1F" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL63</accession>
    <name>C4YL63_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="11">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_01578</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11 14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="11"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL63"/>
    <dbReference type="PaxDb" id="5476-C4YL63"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01578"/>
    <dbReference type="HOGENOM" id="CLU_023296_1_1_1"/>
    <dbReference type="OMA" id="EYPVYNF"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000002">
        <property type="entry name" value="Isocitrate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="6 11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 11 14" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11 15" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="16">
        <location>
            <begin position="12"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="97"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="312"/>
            <end position="317"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ43344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="412" mass="46354" checksum="6D3F532936DD4EC1" modified="2009-07-28" version="1">MGEIQKIKVKNPIVEMDGDEMTRIIWQFIKDKLITPYLDIDLKYYDLGIEYRDQTDDKVTTDAANAILKYGVGVKCATITPDEARVKEFNLKKMWLSPNGTLRNILGGTVFREPIVIDNIPRIVPSWEKPIIIGRHAFGDQYKATDIVVPGAGELKLVFRPKDGGEIQEYPVYNFEGPGVGLSMYNTDASIQDFAESSFQLAIERKLNLFSSTKNTILKKYDGRFKDIFEGLYASKYKTKMDELGIWYEHRLIDDMVAQMLKSKGGYIIAMKNYDGDVQSDIVAQGFGSLGLMTSVLVTPDGKAFESEAAHGTVTRHYRQHQQGKETSTNSIASIYAWTRGLIQRGKLDETPEVVKFAEDLEKAIIDTVGKDNIMTKDLALTQGKTDRSSYVTTEEFIDAVANRLNKNLGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLI8</accession>
    <name>C4YLI8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLI8"/>
    <dbReference type="PaxDb" id="5476-C4YLI8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01706"/>
    <dbReference type="HOGENOM" id="CLU_273098_0_0_1"/>
    <dbReference type="OMA" id="HEPTDEI"/>
    <dbReference type="OrthoDB" id="5595797at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1123"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1123"/>
            <end position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1181" mass="129869" checksum="0F21894A7F8DC51C" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLN5</accession>
    <name>C4YLN5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleolar protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_01754</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLN5"/>
    <dbReference type="PaxDb" id="5476-C4YLN5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01754"/>
    <dbReference type="HOGENOM" id="CLU_005316_3_2_1"/>
    <dbReference type="OMA" id="PIGSWTK"/>
    <dbReference type="OrthoDB" id="427002at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000192">
        <property type="entry name" value="NOP2p rRNA m5C methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1170:FF:000001">
        <property type="entry name" value="Ribosomal RNA methyltransferase Nop2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023273">
        <property type="entry name" value="RCMT_NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF30">
        <property type="entry name" value="28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02012">
        <property type="entry name" value="RCMTNOP2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="265"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="158"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="558"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="593"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="559"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="601"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="482"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="357"/>
            <end position="363"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ43516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="618" mass="69432" checksum="6ABCE402052DFE71" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLS5</accession>
    <name>C4YLS5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="7">1.4.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">PNP/PMP oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_01794</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>pyridoxamine 5'-phosphate + O2 + H2O = pyridoxal 5'-phosphate + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15817"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58451"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>pyridoxine 5'-phosphate + O2 = pyridoxal 5'-phosphate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:15149"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="7"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLS5"/>
    <dbReference type="PaxDb" id="5476-C4YLS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01794"/>
    <dbReference type="HOGENOM" id="CLU_032263_2_0_1"/>
    <dbReference type="OMA" id="AYFRTRP"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.110.10:FF:000010">
        <property type="entry name" value="Pyridoxine phosphate oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="16">
        <location>
            <begin position="77"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="17">
        <location>
            <begin position="204"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ43556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="247" mass="28734" checksum="F6FF2AB49059256E" modified="2009-07-28" version="1">MTLNSTSANPDTRREDPETTTQEPIIFAPATYQYTKGHLGDTEVDKDPLAQFNKWFKEAQDNLPANSDIIVEATNFSTARLPSGRVSSRIVLLKELDKYGFLVYSNWNTSKKAKDFESNKYASLTFFWPHVQRQVRVEGIMEHVTRETSERYFNTRPRGSKIGAWASPQSSVVQSRDDLDQIKDKYNDKFKDLQDHEIPCPDYWGGIRIEPLEVEFWQGGLSRLHDRITYRREKKEDPNWEIVRLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLW0</accession>
    <name>C4YLW0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLW0"/>
    <dbReference type="PaxDb" id="5476-C4YLW0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01830"/>
    <dbReference type="HOGENOM" id="CLU_057148_2_0_1"/>
    <dbReference type="OMA" id="LSFGTWC"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000956">
        <property type="entry name" value="Crg1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="229" mass="25974" checksum="892FC016A85EC62D" modified="2009-07-28" version="1">MVVVVVGSGGGGSIIGIEPTQELIDIANENKSKLVPELTNISFQIGSIYELPFDDDSFDLVHAHQVIIHLQNPIEALKELKRVTKPGGFICIRDADLESSIVSPVEKYESLREFYVIKAKNAISTDTKAGRKLRNKTLEAGYESKNLKTFSSSWLLADDLQIKKSWANATINRIKSDVEKLNVNDPMKNKQMNEKFIKLWQEWSEDETSLFTMIHFEIIYQKPTTTRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLX8</accession>
    <name>C4YLX8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="5 18">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CAWG_01850</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="18">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="18">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="18">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion inner membrane</location>
            <topology evidence="1 18">Peripheral membrane protein</topology>
            <orientation evidence="1 18">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5 18"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLX8"/>
    <dbReference type="SMR" id="C4YLX8"/>
    <dbReference type="PaxDb" id="5476-C4YLX8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01850"/>
    <dbReference type="HOGENOM" id="CLU_044838_0_2_1"/>
    <dbReference type="OMA" id="DGQYFGP"/>
    <dbReference type="OrthoDB" id="1696654at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase iron-sulfur subunit SdhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="16 18" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8 18" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15 18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="19">
        <location>
            <begin position="43"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="166"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EEQ43609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="263" mass="30114" checksum="1F6342FD4E52EAEA" modified="2010-10-05" version="1">MFRSILHQQKAVQFSVRSLATAAAEKAPRLKKFQIYRWNPDTPEVQPKMQTYEVDLNKCGPMVLDALLKIKNEQDATLTLRRSCREGICGSCAMNIGGRNTLACLCRIDQDESKDLKVYPLPHMFVVRDLVPDLTHFYKQYKSIEPYLQRESNPADGRENLQSIEDRAKLDGLYECILCACCSTSCPSYWWNQQQYLGPAVLMQAYRWLIDSRDQATANRKAMLQNSMSLYRCHTIMNCARTCPKGLNPGKAIAEIKKQLAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLY0</accession>
    <name>C4YLY0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_01852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLY0"/>
    <dbReference type="PaxDb" id="5476-C4YLY0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01852"/>
    <dbReference type="HOGENOM" id="CLU_134522_0_0_1"/>
    <dbReference type="OMA" id="PYHAKVH"/>
    <dbReference type="OrthoDB" id="4072889at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="139" mass="16252" checksum="B162200D3D023642" modified="2010-10-05" version="1">MSCFAKVKCFLACIVLYYISYLYNYKCPTLTPLQEGVETILHPLHSHHSVLCDYLHTGINTVEPYTAKVHGFLDDHVHSHPLFIEYKVEDKLTCAKNKFSTYVYPYIHQLYQFTDVAEVHAHEHLSQVYDKVQKTLKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM13</accession>
    <name>C4YM13_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_01888</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM13"/>
    <dbReference type="PaxDb" id="5476-C4YM13"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01888"/>
    <dbReference type="HOGENOM" id="CLU_076155_1_0_1"/>
    <dbReference type="OMA" id="DKWKQAY"/>
    <dbReference type="OrthoDB" id="5550281at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="87"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="87"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="165"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ43644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="223" mass="24785" checksum="56A59CFEF783D3F7" modified="2009-07-28" version="1">MSDLKTTKDTLVSTLFELSKAAQDAANAAIEFYKVASGGSDHVSAEQLKAVSEALNTVATLSSGNGAKIEATESKKKRKQEKDPNAPKKPLTMFFQFSYDLRKKIGIERKKKDLPSLSAIDMNSMIKDRWDSISEAEKAGYKKRYDDAMIIYNIEKKKYEESLKDGSAYYPPPSVQTPIVGHGIEQDFDDDATDIVSSPEEPKKKKKKAEKKEKKKKSGHGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMS4</accession>
    <name>C4YMS4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_02161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMS4"/>
    <dbReference type="PaxDb" id="5476-C4YMS4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02161"/>
    <dbReference type="HOGENOM" id="CLU_1309954_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="210" mass="26079" checksum="D0A284621C820FC7" modified="2009-07-28" version="1">MYFLPYKRLPYIFSHTKNYYVVHAQKIYYVFSHTKKYYIIHHTKKLLVFLPYKKLLCSARTKKLPYIFYYVFFPIQKITMYYTQKKLPYIFYYVFFPIQKNVSVFPIQKNYYVVHPYKKLPYIFSHTKKCYVIHAHKKLPYKKNVSVFSTHTKKYYVIHAKKLLVFFPIQKNYYVVHAQKNCHTFFTMYFFPYKKLLCITRKKNHIQKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMV4</accession>
    <name>C4YMV4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Cysteine dioxygenase</fullName>
            <ecNumber evidence="2 9">1.13.11.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_02191</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-cysteine + O2 = 3-sulfino-L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:61085"/>
            <dbReference type="EC" id="1.13.11.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="9">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.20" evidence="2 9"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMV4"/>
    <dbReference type="SMR" id="C4YMV4"/>
    <dbReference type="PaxDb" id="5476-C4YMV4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02191"/>
    <dbReference type="HOGENOM" id="CLU_079443_4_0_1"/>
    <dbReference type="OMA" id="YTENQVT"/>
    <dbReference type="OrthoDB" id="543511at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017172">
        <property type="term" value="F:cysteine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019448">
        <property type="term" value="P:L-cysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10548">
        <property type="entry name" value="cupin_CDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000273">
        <property type="entry name" value="Cysteine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="CYSTEINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918:SF1">
        <property type="entry name" value="CYSTEINE DIOXYGENASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0883">Thioether bond</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="cross-link" description="3'-(S-cysteinyl)-tyrosine (Cys-Tyr)" evidence="7">
        <location>
            <begin position="157"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ43935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="265" mass="29798" checksum="3E5AA4A66919F4BF" modified="2010-10-05" version="1">MLLNQYTFSAERCTTPTSISHPPLACPTSPPPTNSLNRYQHKPVTLAPTVDHGCEINGTTIDCIPKDSKFYQLIMDLKQLLAGKGLSNEDIDVEKVKQLMADYDSNEIDWQHLALHDPSRNYSRNGIINLNGNANLLILVWSPGKSSAIHDHADAHCCVKMLAGELIEHLYDFPDHEGEELQCRQETSMKRNDVGYINDSIGLHKMSNPLQNRVSVSLHLYTPPYASMYGCSMYEASSGRKHHVDMSKYYSWQGQLVNEKESSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN20</accession>
    <name>C4YN20_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_02259</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for 60S ribosomal subunit synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN20"/>
    <dbReference type="SMR" id="C4YN20"/>
    <dbReference type="PaxDb" id="5476-C4YN20"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02259"/>
    <dbReference type="HOGENOM" id="CLU_015495_4_0_1"/>
    <dbReference type="OMA" id="PDNYMFA"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000001">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000002">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="9">
        <location>
            <begin position="298"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="442"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="460"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ44001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="516" mass="57770" checksum="8879F9CFBE34F465" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNF4</accession>
    <name>C4YNF4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_01413</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNF4"/>
    <dbReference type="PaxDb" id="5476-C4YNF4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01413"/>
    <dbReference type="HOGENOM" id="CLU_047181_1_0_1"/>
    <dbReference type="OMA" id="MNPLVTE"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000009">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="2"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="152"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="8"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="122"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ43187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="337" mass="35988" checksum="ABBBE8FDC22CA0FE" modified="2009-07-28" version="1">MVKVAILGAAGGIGQPLSLLTKLNPNVDELALFDVVNVPGVGADLSHINSDSKTQSYLPKDKEDKTALAAALKGSDLVIIPAGVPRKPGMTRDDLFNINASIVQGLAEGIAANSPKAFVLVISNPVNSTVPIVAETLQAKGVYDPARLFGVTTLDIVRANTFISQLFPDQTKPSDFNINVVGGHSGETIVPLYSLGNSKQYYDILSEEQKKELIKRVQFGGDEVVQAKNGAGSATLSMAYAGYRLAESILAAVNGKTDIVECTFLNLDSSIKGASEARKLVKDLDFFSLPVQLGKNGITEVKYDILNQISDDEKKLLEVAIEQLQKNIEKGVSFAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNF6</accession>
    <name>C4YNF6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hexaprenyl pyrophosphate synthetase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_01416</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNF6"/>
    <dbReference type="PaxDb" id="5476-C4YNF6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01416"/>
    <dbReference type="HOGENOM" id="CLU_014015_1_0_1"/>
    <dbReference type="OMA" id="AFDYYLH"/>
    <dbReference type="OrthoDB" id="9927103at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF69">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ43189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="507" mass="55948" checksum="8A4649D1E986978B" modified="2009-07-28" version="1">MFSFKQFRVSTSSLLTRRIRSRHHSSSTFKTAVETAEKLVTPPTSKFSDPFSIVSHEMSNLAKSIANLIGSGHPTLNRVSSYYFEAEGKNVRPLIVLILSKALSKIPLEQRNRIPIDTIDVTEQKSFNGTPTKQNSTIAGKSIDDSLSPLAILHGINPKVILDPLSKPMDKLPIINGHNKPGDKDNSQGQLDILPKQRRLAEIVEMIHTASLLHDDVIDLSDSRRGRPSGNIAFTNKMAVLAGDFLLGRASVAIARLRNPEVIELLSTTIANLVEGEFMQLKNTVLQNNNNDEIFNDGDVKSIPQPTGKVPTKLHQYSVQQQQRTTNGGDSADAAVVVDHEINVEAAFEYYLHKTYLKTASLMSKSCRAAAVLSGAQDDIIENCYQFGRNLGLCFQIVDDMLDYTSSDKTIGKPSQADLKLGLATAPILFAWKQEPKLGDLIARKFNQPGDVEIARRAVEKYDGVAQTKEMATMYCHQALKNLRVLPESEARSALELLTNSVLTRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNF8</accession>
    <name>C4YNF8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_01418</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNF8"/>
    <dbReference type="PaxDb" id="5476-C4YNF8"/>
    <dbReference type="HOGENOM" id="CLU_002842_1_0_1"/>
    <dbReference type="OMA" id="DDRGPDF"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="CDD" id="cd14483">
        <property type="entry name" value="SPX_PHO81_NUC-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051616">
        <property type="entry name" value="Cul2-RING_E3_ligase_SR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224:SF64">
        <property type="entry name" value="IQ MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPX" evidence="3">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="492"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="568"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="602"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="668"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="669"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ43191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1144" mass="128382" checksum="FCB9EACC6FA7FE4E" modified="2009-07-28" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNV8</accession>
    <name>C4YNV8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Beta-glucan synthesis-associated protein KRE6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_02891</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNV8"/>
    <dbReference type="CAZy" id="GH16">
        <property type="family name" value="Glycoside Hydrolase Family 16"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YNV8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02891"/>
    <dbReference type="HOGENOM" id="CLU_010811_4_3_1"/>
    <dbReference type="OMA" id="AHIEAYT"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000140">
        <property type="entry name" value="Beta-glucan synthesis-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="348"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="175"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ44617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="737" mass="83708" checksum="E2850C1142F86C76" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNZ1</accession>
    <name>C4YNZ1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TGF beta-inducible nuclear protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_02925</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the pre-66S ribosomal particle. Interacts with NOP7 and RRP1. Interacts with RSA4 (via WD repeats).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNZ1"/>
    <dbReference type="PaxDb" id="5476-C4YNZ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02925"/>
    <dbReference type="HOGENOM" id="CLU_118231_0_1_1"/>
    <dbReference type="OrthoDB" id="1847590at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ44650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="129" mass="14273" checksum="2098585868C0ADE3" modified="2010-10-05" version="1">MFKVIKTGKSKSKSWKRMITKHTFVGEGFTRRPVKMERIIRPAALRQKKANVTHPELGVTVFLPILGVKKNPQSPMYTQLGVLTKGTIIEVNVSELGLVTAGGKVVWGKYAQITNEPDRDGCVNAVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP48</accession>
    <name>C4YP48_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_02986</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YP48"/>
    <dbReference type="SMR" id="C4YP48"/>
    <dbReference type="PaxDb" id="5476-C4YP48"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02986"/>
    <dbReference type="HOGENOM" id="CLU_167752_2_0_1"/>
    <dbReference type="OMA" id="KPDQKEY"/>
    <dbReference type="OrthoDB" id="2401875at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ44707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="68" mass="7628" checksum="57D6B59B8B636CAD" modified="2009-07-28" version="1">MAAEGLEKLTEVPVEFFKDGSAFVKKCQKPDEKEYLKIIRAVGIGFIMMGVVGYAVKLVHIPIRYLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP77</accession>
    <name>C4YP77_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ER-derived vesicles protein ERV14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_03021</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cornichon family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YP77"/>
    <dbReference type="PaxDb" id="5476-C4YP77"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03021"/>
    <dbReference type="HOGENOM" id="CLU_112942_0_0_1"/>
    <dbReference type="OMA" id="HKKECFI"/>
    <dbReference type="OrthoDB" id="434393at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01398">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ44736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="110" mass="13202" checksum="F6E5CEF8DAB91783" modified="2010-10-05" version="1">MYSDLECDYINPIELCNKLNPWFIPEAGLHGFITVLFLINGYWFCFLLNLPLFAYNANKFYNKNHLLDATEIFRTLSKHKKESFLKLGFHLLLFFFYLYRMIMALVNDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPI2</accession>
    <name>C4YPI2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="3">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Nuclear thiol peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_02383</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="3"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPI2"/>
    <dbReference type="SMR" id="C4YPI2"/>
    <dbReference type="PaxDb" id="5476-C4YPI2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02383"/>
    <dbReference type="HOGENOM" id="CLU_042529_2_1_1"/>
    <dbReference type="OMA" id="CGFRDNF"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000157">
        <property type="entry name" value="DOT5p Nuclear thiol peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF23">
        <property type="entry name" value="PEROXIREDOXIN DOT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="44"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="189"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEQ44121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="263" mass="29137" checksum="FBAA03F20D48907F" modified="2010-10-05" version="1">MPELRRSARVAARPAKEPEAVTEQPPTKKVKTAPTNTAKPDAGLGIGEKIPDVTLLNQDGEEISLTEVAKGSKYVVIFAFPRASTSGCARQVSGFRKLDKDYKDVSIFGVSSDSVKAQKNFQTKQNAEYDLLSDPEKKLIGALGAKKHPSGIIRSHWIFVDGVLKVKQIQVSPEVSFTSAEEEIKKFINENENGKEATENDVTKEEVKEESQQDDKEDNTEQTDEKATEQTQDEVKKVSDETKVEDETEEKPTEEQKTEAPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPI6</accession>
    <name>C4YPI6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NEDD8-conjugating enzyme UBC12</fullName>
            <ecNumber evidence="7">2.3.2.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NEDD8-conjugating enzyme Ubc12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">RUB1-conjugating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin carrier protein 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_02387</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.34" evidence="7"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPI6"/>
    <dbReference type="SMR" id="C4YPI6"/>
    <dbReference type="PaxDb" id="5476-C4YPI6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02387"/>
    <dbReference type="HOGENOM" id="CLU_030988_6_0_1"/>
    <dbReference type="OMA" id="CQVDFPD"/>
    <dbReference type="OrthoDB" id="10249039at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061654">
        <property type="term" value="F:NEDD8 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000005">
        <property type="entry name" value="NEDD8-conjugating enzyme Ubc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="41"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="12">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEQ44125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="194" mass="22166" checksum="0D52D15E81BD598D" modified="2010-10-05" version="1">MLKIRQLQKKKQEEAERLAKSQSTTPTPGDSTSTSNQRVSPAQIRVQKDISELDLPSSIRVTFPNPNDLFNFNLQLIPQAGYYKNGKFEFKIEINSNFPIDPPKIKCLQKIYHPNIDLQGNICLNILREDWSPVLSLTGVFMGLNFLFLDPNATDPLNKDAANVLVKNRKQFEINVFNSMRGGYLDSVYYDRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ14</accession>
    <name>C4YQ14_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_02568</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ14"/>
    <dbReference type="PaxDb" id="5476-C4YQ14"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02568"/>
    <dbReference type="HOGENOM" id="CLU_065214_0_1_1"/>
    <dbReference type="OMA" id="IHDSYSM"/>
    <dbReference type="OrthoDB" id="10253553at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009244">
        <property type="entry name" value="Mediatior_Med7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044888">
        <property type="entry name" value="Mediatior_Med7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428:SF11">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05983">
        <property type="entry name" value="Med7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="42"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="119"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ44303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="299" mass="34029" checksum="78BC919B41935F9C" modified="2009-07-28" version="1">MSTNNTTTNNEDLISSLYPPPPPYYKFFTKDNLQKLSTWQENNQTTTVSSEVKLEEENTDPDSNNSEENSIPPGELRFLIPPKQPEGPQYRGYGNIWLFEDKLPNLKDSQWEQLYNTSTSTSTSTANTNIITNTDTDINGNQEVDAGDSTGDENLTSETKIKELHKLMDSLLLNFLELIGILSIDPIKYDKKIHDINLILININHLLNTYRPHQSRESLIMLLKNQIDYKFLEIDQINKKCLDIKSKIKNLINERITVVSDDTTTNTTTTKTTGLGDGDSIDEKEQLKQDIINRLLSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ33</accession>
    <name>C4YQ33_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_02587</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ33"/>
    <dbReference type="PaxDb" id="5476-C4YQ33"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02587"/>
    <dbReference type="HOGENOM" id="CLU_017483_0_0_1"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF88">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="72"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="239"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="622"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="82"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="630"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ44322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="838" mass="95142" checksum="E24576D929F26D79" modified="2009-07-28" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ38</accession>
    <name>C4YQ38_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_02592</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ38"/>
    <dbReference type="PaxDb" id="5476-C4YQ38"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02592"/>
    <dbReference type="HOGENOM" id="CLU_031307_0_0_1"/>
    <dbReference type="OMA" id="KNWENTF"/>
    <dbReference type="OrthoDB" id="377083at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="383"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="515"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ44327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="586" mass="67169" checksum="8E5F59E5DB922875" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ47</accession>
    <name>C4YQ47_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_02601</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ47"/>
    <dbReference type="SMR" id="C4YQ47"/>
    <dbReference type="PaxDb" id="5476-C4YQ47"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02601"/>
    <dbReference type="HOGENOM" id="CLU_000022_45_4_1"/>
    <dbReference type="OMA" id="WYHSIGL"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="148"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ44336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="718" mass="80376" checksum="0FDD03C8212E834C" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQC5</accession>
    <name>C4YQC5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">20S-pre-rRNA D-site endonuclease NOB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_02682</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NOB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQC5"/>
    <dbReference type="PaxDb" id="5476-C4YQC5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02682"/>
    <dbReference type="HOGENOM" id="CLU_024666_2_1_1"/>
    <dbReference type="OMA" id="GYELECE"/>
    <dbReference type="OrthoDB" id="446759at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09876">
        <property type="entry name" value="PIN_Nob1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000020">
        <property type="entry name" value="20S-pre-rRNA D-site endonuclease NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.10">
        <property type="entry name" value="Nin one binding (NOB1), Zn-ribbon-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017117">
        <property type="entry name" value="Nob1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036283">
        <property type="entry name" value="NOB1_Zf-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014881">
        <property type="entry name" value="NOB1_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08772">
        <property type="entry name" value="Zn_ribbon_NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037125">
        <property type="entry name" value="D-site_20S_pre-rRNA_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144206">
        <property type="entry name" value="NOB1 zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ribonuclease PIN" evidence="11">
        <location>
            <begin position="10"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Nin one binding (NOB1) Zn-ribbon-like" evidence="10">
        <location>
            <begin position="296"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="121"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037125-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ44414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="466" mass="52544" checksum="EE42107C3BEA8117" modified="2009-07-28" version="1">MSETKNIESLILDAGPLITQPATTLQQYATAYYTTPGVHSELKDEYARQQLAIWGDSLKIKQPKQEYIDRVVKFAKLTGDYSVLSVNDLHIVALAYELECLNNGEDNLRSFPGEVLKNQQAENENGSNKMSNIIGDDDGFVVATKRRGGRRQREKAELRKKGLSPTFSPKPKGGSETEEPNESSNDKTIDETPQTDLIKGVDVQEQESQEEPASESNTVGLDEITEEYNEDDDDGEWITPENLQEEIIKDKNEQVQESNTNGPLIKVALATGDFACQNVAMQIGIKLLNAMSGKQITRVRNYMYRCHACFRLTPMSKDGRPKHFCPKCGGNTLLRCAVSVDNKTGKITPHLKQNFQWIRRGERYSLPSPLSKNQKKLQGNGGYQHNKENRHKSLQTPLILNEDQKEYQRALKNDEWERKQQDKMLQDWIGGGSADNFVSPFGNTIRNSGVKVGRGRYANSSKKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQE5</accession>
    <name>C4YQE5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQE5"/>
    <dbReference type="PaxDb" id="5476-C4YQE5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02702"/>
    <dbReference type="HOGENOM" id="CLU_1031205_0_0_1"/>
    <dbReference type="OMA" id="NYDTHME"/>
    <dbReference type="OrthoDB" id="3997968at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="238" mass="26660" checksum="8965568C7940482D" modified="2009-07-28" version="1">MSSSNDTPSSFVTPQTPPRQQQRRKSNTGAISTPVASSVLLTPSTTTKKPTRTPVSQKRKQGVQLSPPQANKFPFTPITPQKSPCKTRKNLDLFTSNEKFGLLLPSPSTIGSGRCHNSFTQAPPPLFDLKKVNEFKVPKTPAKQIIDNSRTKESENEDDWEVMDIDEVAKIPRAKLRNPFIDTFEPTSPVTPEESTGDRINYDTHMELINSKTGKKRVVKLTKNQMKIKPKRLSFDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQK9</accession>
    <name>C4YQK9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_02768</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQK9"/>
    <dbReference type="PaxDb" id="5476-C4YQK9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02768"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="OMA" id="RPKVQPC"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="27"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ44498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="415" mass="46837" checksum="CC9F0C4ADBC2315C" modified="2009-07-28" version="1">MTKTGKFTPWDETTGNKTTTANNTSYILSKKPLGDGSYSVVFECKNTSTGRHYAAKKYTKRLMYGFENMLKNEFKVLNRISLSHSHLLSLIDFFETEESFYLVTDLARGGDLWNKIAEEEKLNEQTTRTITRQLVESVEFLHKHQILHHDIKAENVFFQSKHQDTILLGDFGLAKILQPQEKLHEVAGTLSYMAPEMLDYKIGYDFPIDVWALGVCVYFMLCGYMPFDCDDDEETKDAIRNRKYLFEPSEYWVDVSSEAKDFILACLQVDPQKRLTASQLLQHSFLKINSTKPAITISSPLKRSFSNLSALQRDQIKNILQKVGGVSAPALSHSSSINEKLERGRFDSLNKDATLNGAICPSPECVSIFSSPANSTSVSRDGSGLNIFEESLKWDSSQKKALPLNTLRQGASFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR13</accession>
    <name>C4YR13_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glucose-6-phosphate 1-epimerase</fullName>
            <ecNumber evidence="3 5">5.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_04511</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
            <dbReference type="EC" id="5.1.3.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glucose-6-phosphate 1-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.15" evidence="3 5"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR13"/>
    <dbReference type="PaxDb" id="5476-C4YR13"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04511"/>
    <dbReference type="HOGENOM" id="CLU_048345_2_0_1"/>
    <dbReference type="OMA" id="TQALHSY"/>
    <dbReference type="OrthoDB" id="1659429at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09020">
        <property type="entry name" value="D-hex-6-P-epi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000023">
        <property type="entry name" value="Glucose-6-phosphate 1-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025532">
        <property type="entry name" value="G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF13">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016020">
        <property type="entry name" value="PHexose_mutarotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ46166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="299" mass="33825" checksum="635D701C2B3029D0" modified="2009-07-28" version="1">MPVEELEDRVIITDPNDSTNRATILKFGATVVSWKNNNQEKLWLSEGAHLDGSKAVRGGIPLVFPVFGKQKDSNHPTFKLPQHGFARNSTWEFLGQTQESPITVQFGLGPENVDPETLKLWNYDFTLILTVSLTKDKLVTSIDVENTGKEAFEFNWLFHTYYRIHDITDTLVTNLIDQQCYDQLIGESYIEKAPVISFHEEFDRIYSKVSLEKSIQVVDKGQVLFNLHRKNLPDSVVWNPWTKKAEGMADFQPKSGFHQMVCVEPGHVNSMVSLPPGGKWSGGQEITIGGEIKVQANIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR69</accession>
    <name>C4YR69_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_04568</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR69"/>
    <dbReference type="PaxDb" id="5476-C4YR69"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04568"/>
    <dbReference type="HOGENOM" id="CLU_298082_0_0_1"/>
    <dbReference type="OMA" id="ANHICAS"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="65"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="820"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="929"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="963"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="826"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="858"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="929"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="940"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="963"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ46222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1009" mass="115618" checksum="46658C09536A3E3B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRD8</accession>
    <name>C4YRD8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U3 small nucleolar RNA-associated protein 13 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04637</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRD8"/>
    <dbReference type="PaxDb" id="5476-C4YRD8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04637"/>
    <dbReference type="HOGENOM" id="CLU_009276_0_0_1"/>
    <dbReference type="OMA" id="PYVQRHF"/>
    <dbReference type="OrthoDB" id="5414888at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002462">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013934">
        <property type="entry name" value="Utp13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF15">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08625">
        <property type="entry name" value="Utp13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="139"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="185"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="239"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="377"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="423"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="474"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="516"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="558"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="601"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 13 C-terminal" evidence="6">
        <location>
            <begin position="654"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ46291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="799" mass="90139" checksum="E015FEA3758F906A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRE3</accession>
    <name>C4YRE3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04642</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRE3"/>
    <dbReference type="PaxDb" id="5476-C4YRE3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04642"/>
    <dbReference type="HOGENOM" id="CLU_029274_0_0_1"/>
    <dbReference type="OMA" id="QECMGFL"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000017">
        <property type="entry name" value="Proline dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF0">
        <property type="entry name" value="PROLINE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="6">
        <location>
            <begin position="207"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ46296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="492" mass="55575" checksum="FCAC4AEC41BE8C01" modified="2009-07-28" version="1">MSIRLYSKQSLNTFKKATFIPLTTTATTAITTTQFRYFHDTPNKQNVTVNNMMPRVTKPTPTNTFTTSPQLPSTEYLKAFNNKELISFFMIGLATLNKPILQLCIKLFPYVPMSIIKALVYRIYCGGETIDQVKKTGLRLHERGINNMMISLTIEACDGNDNVDPKYIVEETAKSIETILVPHTVAMIEQATDDINDIPPGYVALKPTGFAKDAANVLKNYNTTMIKEFDELVDKAIIVCQKIYDSNKELSQKYPERVSPFVVGVIDAEKHELQEGVYELQRRLYQKFNKLNQPISIVGTLQMYLSDSANLLTKEENLANENNYRLGLKLVRGAYIHSEKNRDIVIHKTKQDTDNNYNSGISYCIDSILNQNQNQNQNGSTIGHLVVASHNAESMRLASDKVYNPMNESNKNKTNVVLGQLLGMADNVTYDLITNNKIGNVIKYVPWGPPLETKEYLLRRLEENGDAVKNDNGWPLVKASFKMLTKRLFGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRF4</accession>
    <name>C4YRF4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_04653</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">WO-1</strain>
        </source>
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        <subcellularLocation>
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    </comment>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="116"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
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        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
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            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ46307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="831" mass="94951" checksum="434206C3417E6C1B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRJ9</accession>
    <name>C4YRJ9_CANAW</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YRJ9"/>
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    <dbReference type="OMA" id="MTIIFQP"/>
    <dbReference type="OrthoDB" id="4022940at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="512" mass="56547" checksum="79C41983C6CDEF88" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRK3</accession>
    <name>C4YRK3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YRK3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04703"/>
    <dbReference type="HOGENOM" id="CLU_011226_3_2_1"/>
    <dbReference type="OMA" id="MAIALYI"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="83"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="219" mass="25139" checksum="937F892B8F91B122" modified="2009-07-28" version="1">MSQGILYVLKLSPRSSILTDLIKYYKLDIEISTDTESESFIEKFPLRKTPTFIGNDGFQLTETIAIGIYFLSMIPNHDLLGDNDQEFASIIRFLSMLNQEGAMSWVGAFFRLSGRLPYNKEIIDENLITLDIIGQILDKRLANDRISGYLVGDKISYADLYGVKLFGIALYTLLGEPYLTKYPNFAKWFKRASDNEFFRGQYKDIKFPQQQLTYPGSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRS3</accession>
    <name>C4YRS3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_04780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CKS family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRS3"/>
    <dbReference type="SMR" id="C4YRS3"/>
    <dbReference type="PaxDb" id="5476-C4YRS3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04780"/>
    <dbReference type="HOGENOM" id="CLU_140546_0_0_1"/>
    <dbReference type="OMA" id="RPINYGQ"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.170.10:FF:000002">
        <property type="entry name" value="Cyclin-dependent kinases regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00944">
        <property type="entry name" value="CKS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00945">
        <property type="entry name" value="CKS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ46426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="102" mass="12157" checksum="7B5C96A096768B03" modified="2010-10-05" version="1">MTKPRFLTDIERAKVLEFQDMIHYSPRYSDDSYEYRHVMLPKNMLKAIPHDYFNQETGTLRILTEEEWRGLGITQSLGWAHYETHAPEPHILLFKRPLNPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRT7</accession>
    <name>C4YRT7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRT7"/>
    <dbReference type="PaxDb" id="5476-C4YRT7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04794"/>
    <dbReference type="HOGENOM" id="CLU_1085845_0_0_1"/>
    <dbReference type="OMA" id="DEANIHD"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28492" checksum="F3DB94CDC2E40562" modified="2009-07-28" version="1">MSSQAVTASIIRGSQVVVTTIILAVSIKALAVLGIYYDKSRPTFYITVVAELDIIYFCYTLLLTPLVFKKFSPSIIPTASEFILYTLNLAAMCISTINSPTVYCDEFYYSDTIDLCYIHQCLHGFSVTNWVLFTISFMMILYCTFIPEIKRHGVKHTLSPSQFYISCIIIDDNPKSIEVIASESASLDEANIHDESEIGMAPTVYATNNTSSLDANNAIADSNLESSEDEKSIQKIPIEAVYEKTDISKPYASKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS04</accession>
    <name>C4YS04_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS04"/>
    <dbReference type="PaxDb" id="5476-C4YS04"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04862"/>
    <dbReference type="HOGENOM" id="CLU_018929_0_0_1"/>
    <dbReference type="OMA" id="DHLFKQY"/>
    <dbReference type="OrthoDB" id="4068467at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="801"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="615"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="801"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="837" mass="92886" checksum="A0155AEBF2D91F30" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS33</accession>
    <name>C4YS33_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS7m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_04891</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS33"/>
    <dbReference type="SMR" id="C4YS33"/>
    <dbReference type="PaxDb" id="5476-C4YS33"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04891"/>
    <dbReference type="HOGENOM" id="CLU_049057_2_0_1"/>
    <dbReference type="OMA" id="HVTNMIM"/>
    <dbReference type="OrthoDB" id="9972728at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14868">
        <property type="entry name" value="uS7_Mitochondria_Fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000006">
        <property type="entry name" value="37S ribosomal protein S7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047988">
        <property type="entry name" value="Ribosomal_uS7m_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="9">
        <location>
            <begin position="98"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ46536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="251" mass="28479" checksum="383E0BA9DAC932A5" modified="2010-10-05" version="1">MSLIRAFTAASRVPRASLLSCVAVRFNSTSKASKQPLLAEIYPLNKDSITEKDLDNWIDAVKQLKSGKASHETPEEIYLGQLSQPQQFLKQTYEPTVDQIEETKKYANKKIPLRSDPTVDNLTNLIMRHGKKAKAQKVVSRALYIVQLKLRKDPIEVLRETLDKLGPLVNTKTMSTGVAKKRVVPIPLNEKQRNRFAIKWILEASNSRKSNDFSVRLAEEIINAYQGKSSGYDKKAQMHKQATQQRAYINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSC2</accession>
    <name>C4YSC2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_04985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSC2"/>
    <dbReference type="PaxDb" id="5476-C4YSC2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04985"/>
    <dbReference type="HOGENOM" id="CLU_065016_0_0_1"/>
    <dbReference type="OMA" id="CVCLDRS"/>
    <dbReference type="OrthoDB" id="10251741at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051510">
        <property type="entry name" value="SKI8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090:SF1">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="282"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ46625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="384" mass="41877" checksum="5341BC7603CB2DC8" modified="2009-07-28" version="1">MGKQYISTVSASQAHKSDILGVAITNKFTVSVSSDGYAKFWDNKQDEVHSPKEFVQSVFIDKSGIHAVAVYENVLPSSTLKVTLLAFACFNGSIIFRYYINDDFSTIESLTDDIKSFESNCWTPGFYRDPESKQDYFITTKTNGTTEVHLLNIVDENEKAVITFEKFGQLKGNSSSFPNSLAICPTENKKCAVGYINGDVLLYDFVSLKLIYTFRSSDLVTSRNSQSTSIPRVLAFSPGGTLLAVARDNQAAGSITLYDVEHGENVGSLATPSHSAKSVVGGFAHQGWILGLSFDEEGKHLASCGFDKCIRVWNLETSEREATISISISDLDDTTHNDQDESVASGVAFIKKGVRGGSGGDSNEGLCVVSFDRGIRWYREAGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSC4</accession>
    <name>C4YSC4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
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                <person name="Sakthikumar S."/>
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                <person name="Rheinbay E."/>
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                <person name="Forche A."/>
                <person name="Reedy J.L."/>
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                <person name="Logue M.E."/>
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                <person name="Lorenz M.C."/>
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    <sequence length="1159" mass="123119" checksum="174A60C68CB1503E" modified="2009-07-28" version="1"> </sequence>
</entry>
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    <accession>C4YSY0</accession>
    <name>C4YSY0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_05675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSY0"/>
    <dbReference type="PaxDb" id="5476-C4YSY0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05675"/>
    <dbReference type="HOGENOM" id="CLU_020178_0_2_1"/>
    <dbReference type="OMA" id="RDYNAVN"/>
    <dbReference type="OrthoDB" id="2140105at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF1">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="504"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="559"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="3">
        <location>
            <begin position="181"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ47116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="609" mass="68886" checksum="C6E1BDA61463FEAE" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSZ9</accession>
    <name>C4YSZ9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Histidinol-phosphatase</fullName>
            <shortName evidence="8">HolPase</shortName>
            <ecNumber evidence="3 8">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_05696</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-histidinol phosphate + H2O = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="3 8"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSZ9"/>
    <dbReference type="PaxDb" id="5476-C4YSZ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05696"/>
    <dbReference type="HOGENOM" id="CLU_054611_0_1_1"/>
    <dbReference type="OMA" id="DYDRPMY"/>
    <dbReference type="OrthoDB" id="5957391at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12110">
        <property type="entry name" value="PHP_HisPPase_Hisj_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000192">
        <property type="entry name" value="Histidinol-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="HISTIDINOL PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039:SF0">
        <property type="entry name" value="HISTIDINOL-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="9">
        <location>
            <begin position="4"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ47135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="318" mass="37005" checksum="D3D13D02E616C8C4" modified="2009-07-28" version="1">MHTHHSHSGDYVSHAVDTLNDMIELYYKKGFQIICLTEHMPRLDNKFLYPEEIDKSYTIDNLNGDFTRYLNHARDLQLKYATKDKSSSGNMKIIIGFEVEGINIDHINYSQELLNKVQMSVGSVHFVNEIPIDFNKELWLKARESTKSKTTRELYNDYFELQYKVITQLKPTVVGHFDLIRLLQPEDDIDPTTGKLTKDVNLEIDWPDIWQLVIRNIKFVKSYGGLFELNSSALRKGWDTPYPKRDIANAIIEYGDSRFCLSDDAHSLSQVGIFYSKAWEYVESLGMENIYHLDLDDNGEVVISSKKIQELNNSLFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT17</accession>
    <name>C4YT17_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar complex-associated protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_05715</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT17"/>
    <dbReference type="PaxDb" id="5476-C4YT17"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05715"/>
    <dbReference type="HOGENOM" id="CLU_012441_3_1_1"/>
    <dbReference type="OMA" id="HYCPQVR"/>
    <dbReference type="OrthoDB" id="10263597at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011501">
        <property type="entry name" value="Noc3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07540">
        <property type="entry name" value="NOC3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028977">
        <property type="entry name" value="Nucleolar_complex_p3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nucleolar complex-associated protein 3 N-terminal" evidence="8">
        <location>
            <begin position="138"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="CCAAT-binding factor" evidence="7">
        <location>
            <begin position="531"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="361"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="376"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="503"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR028977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ47153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="740" mass="84897" checksum="0D06ED0286955C6B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT69</accession>
    <name>C4YT69_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT69"/>
    <dbReference type="PaxDb" id="5476-C4YT69"/>
    <dbReference type="HOGENOM" id="CLU_1532329_0_0_1"/>
    <dbReference type="OMA" id="HRCKSTN"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="165" mass="19031" checksum="C56FE8F47054E583" modified="2009-07-28" version="1">MTKTFCDSCRGVGHSRWNCKSVKYCHRCKSTNHPTGKHNQFIKQQTKKQQQQNSKPSNNNTTKTNNNKRQRRDNPQSTRVGRGFILENSSTIEPTPRTYEQELDSFVRRNKAQQQQTQSQEEGDTTRVIGQQPIVPTQADEIVKIVEDENMSDDEPIRVVANARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTN8</accession>
    <name>C4YTN8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_05533</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 12">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Vacuole membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTN8"/>
    <dbReference type="PaxDb" id="5476-C4YTN8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05533"/>
    <dbReference type="HOGENOM" id="CLU_085752_1_1_1"/>
    <dbReference type="OMA" id="MSVCPPY"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000003">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="4 12" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="21"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="98"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ46979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="163" mass="16715" checksum="DCD6BFCA917D71BA" modified="2009-07-28" version="1">MSETLGDEYYPSFAPFLGFAGCAAAMVLSCVGAAIGTAKSGIGIAGIGTFKPELIMKSLIPVVMSGILSVYGLVVSVLIAGGLSPQENYSLFNGCMHLACGLAVGFACLASGYAIGIVGDEGVRQFMHQPRLFVGIVLILIFAEVLGLYGMIIALILNTKGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTX9</accession>
    <name>C4YTX9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTX9"/>
    <dbReference type="PaxDb" id="5476-C4YTX9"/>
    <dbReference type="HOGENOM" id="CLU_016174_1_0_1"/>
    <dbReference type="OMA" id="ELESFAC"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="551" mass="63289" checksum="CCA67B6FCB97E89A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-07-15" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>O13359</accession>
    <accession>C4YDD7</accession>
    <name>KEX2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>Kexin</fullName>
            <ecNumber>3.4.21.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>KEX2 protease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">KEX2</name>
        <name type="ORF">CAWG_00530</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="J. Biol. Chem." volume="272" first="28954" last="28961">
            <title>KEX2 influences Candida albicans proteinase secretion and hyphal formation.</title>
            <authorList>
                <person name="Newport G.R."/>
                <person name="Agabian N."/>
            </authorList>
            <dbReference type="PubMed" id="9360967"/>
            <dbReference type="DOI" id="10.1074/jbc.272.46.28954"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>Cleavage of -Lys-Arg-|-Xaa- and -Arg-Arg-|-Xaa- bonds to process yeast alpha-factor pheromone and killer toxin precursors.</text>
            <dbReference type="EC" id="3.4.21.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">O-glycosylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="6">
        <conflict type="frameshift">
            <sequence resource="EMBL-CDS" id="AAB80929" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="3.4.21.61"/>
    <dbReference type="EMBL" id="AF022372">
        <property type="protein sequence ID" value="AAB80929.1"/>
        <property type="status" value="ALT_FRAME"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O13359"/>
    <dbReference type="SMR" id="O13359"/>
    <dbReference type="GlyCosmos" id="O13359">
        <property type="glycosylation" value="6 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-O13359"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00530"/>
    <dbReference type="HOGENOM" id="CLU_002976_2_1_1"/>
    <dbReference type="OMA" id="AYEFDII"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="PHI-base" id="PHI:306"/>
    <dbReference type="PHI-base" id="PHI:9474"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007323">
        <property type="term" value="P:peptide pheromone maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000005">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000026">
        <property type="entry name" value="proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0106">Calcium</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0720">Serine protease</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000027041" evidence="2">
        <location>
            <begin position="21"/>
            <end status="unknown"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000027042" description="Kexin">
        <location>
            <begin status="unknown"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin status="unknown"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="775"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="796"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8" evidence="4">
        <location>
            <begin position="179"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="3">
        <location>
            <begin position="498"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="671"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="798"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="677"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="711"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="740"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="798"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="820"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="832"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="850"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="860"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="902"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="921"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="512"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="539"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="599"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="267"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="359"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAB80929." evidence="6" ref="1">
        <original>N</original>
        <variation>D</variation>
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAB80929." evidence="6" ref="1">
        <original>F</original>
        <variation>S</variation>
        <location>
            <position position="831"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAB80929." evidence="6" ref="1">
        <original>T</original>
        <variation>A</variation>
        <location>
            <position position="868"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAB80929." evidence="6" ref="1">
        <original>E</original>
        <variation>EEEE</variation>
        <location>
            <position position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="938" mass="105144" checksum="7E72BE8AD9FAA9FF" modified="2011-10-19" version="2" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCM3</accession>
    <name>C4YCM3_CANAW</name>
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        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
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    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_00257</name>
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    <organism evidence="17 18">
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        <name type="common">Yeast</name>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="17 18">WO-1</strain>
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    </reference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-0347">Helicase</keyword>
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        <location>
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            <end position="626"/>
        </location>
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        <location>
            <begin position="446"/>
            <end position="484"/>
        </location>
    </feature>
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        <location>
            <begin position="448"/>
            <end position="472"/>
        </location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ42059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="811" mass="93319" checksum="A5CBD33105233AE7" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD00</accession>
    <name>C4YD00_CANAW</name>
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        <recommendedName>
            <fullName evidence="3">Glycerophosphocholine acyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_00387</name>
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    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
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                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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                <person name="Cuomo C.A."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPC1 family.</text>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00387"/>
    <dbReference type="HOGENOM" id="CLU_018994_1_2_1"/>
    <dbReference type="OMA" id="YIDYYGK"/>
    <dbReference type="OrthoDB" id="406287at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021261">
        <property type="entry name" value="GPCAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201">
        <property type="entry name" value="OS01G0585100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10998">
        <property type="entry name" value="DUF2838"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="349"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ42186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="393" mass="45870" checksum="EACF38ED84A4BAB4" modified="2009-07-28" version="1">MSKLMFANDFDFGLNLNEMKTKTKQKLHTKNLELDKLQEIINQRLQNFDKRVHKQLESSATEKAFYATSVFLIFCAGFIIGKYPIYFPYFHTALFVVLMPIRFYTYFKSSFQYYLADLCYYVNLLLMLFIWVFPESPTLFVSVFSLSLGTLSWAVITWRNSLVLHSIEKTTSSFIHVMPPVTMFVMVHELPEEYIKSRYPGIAAIDNWNFVASIITTSIYYTIWQVSYHYFISIRKKDQIEKGKVTSFSYLKNKNKSTPLGKFVNGLPYLWMQTLAFTLIQFFYQVLTMTPCPIWFKYKHACGAFVVFIFLWASYNGATYYIDVFGKRLEKEVDKLKKEVINLQQENEKIKNSPVQRPVNGSVDDVGALDEDLNSESKEKEQVESTDDKGVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD15</accession>
    <name>C4YD15_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_00403</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD15"/>
    <dbReference type="PaxDb" id="5476-C4YD15"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00403"/>
    <dbReference type="HOGENOM" id="CLU_015387_0_0_1"/>
    <dbReference type="OMA" id="GHINGED"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000033">
        <property type="term" value="F:alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392:SF1">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ42201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="828" mass="97515" checksum="07020201A8EBD40F" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD22</accession>
    <name>C4YD22_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_00410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YD22"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00410"/>
    <dbReference type="HOGENOM" id="CLU_254915_0_0_1"/>
    <dbReference type="OMA" id="ITCTAQI"/>
    <dbReference type="OrthoDB" id="5559898at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038739">
        <property type="entry name" value="ARMC8/Vid28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651:SF7">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="677"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1146"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1289"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1347"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="677"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="721"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1154"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1175"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1309"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1347"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1375"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1403"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1420"/>
            <end position="1439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ42208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1439" mass="164565" checksum="73575A26DEDEDB18" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD41</accession>
    <name>C4YD41_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent RNA helicase DBP3</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP-dependent RNA helicase dbp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAWG_00429</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD41"/>
    <dbReference type="PaxDb" id="5476-C4YD41"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00429"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_5_1"/>
    <dbReference type="OMA" id="KKTHDMY"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="149"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="350"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEQ42227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="529" mass="58903" checksum="AD0A28A0592F983F" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD88</accession>
    <name>C4YD88_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein YTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">YTM1</name>
        <name evidence="9" type="ORF">CAWG_00478</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD88"/>
    <dbReference type="PaxDb" id="5476-C4YD88"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00478"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_0_1"/>
    <dbReference type="OMA" id="DHKYVEF"/>
    <dbReference type="OrthoDB" id="10251381at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDG1</accession>
    <name>C4YDG1_CANAW</name>
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    </protein>
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        <name evidence="6" type="ORF">CAWG_00555</name>
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        <name type="scientific">Candida albicans (strain WO-1)</name>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ42347.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1372" mass="153881" checksum="46AAC519232A4CE7" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDW7</accession>
    <name>C4YDW7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_00715</name>
    </gene>
    <organism evidence="11 12">
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        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
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            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EEQ42503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDW7"/>
    <dbReference type="PaxDb" id="5476-C4YDW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00715"/>
    <dbReference type="HOGENOM" id="CLU_006926_0_0_1"/>
    <dbReference type="OMA" id="CLVYCQV"/>
    <dbReference type="OrthoDB" id="2110361at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="205"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="773"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="205"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="778"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="794"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ42503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="941" mass="106047" checksum="6D432EEC1D7F3574" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDX3</accession>
    <name>C4YDX3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha,alpha-trehalase</fullName>
            <ecNumber evidence="4">3.2.1.28</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_00721</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="4"/>
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        <property type="protein sequence ID" value="EEQ42509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDX3"/>
    <dbReference type="PaxDb" id="5476-C4YDX3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00721"/>
    <dbReference type="HOGENOM" id="CLU_006285_4_0_1"/>
    <dbReference type="OMA" id="NHVDAGG"/>
    <dbReference type="OrthoDB" id="200349at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.40:FF:000003">
        <property type="entry name" value="Acid trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000032">
        <property type="entry name" value="Vacuolar acid trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="entry name" value="Glycoside hydrolase, family 65, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="GH65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11051">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11051:SF8">
        <property type="entry name" value="PROTEIN-GLUCOSYLGALACTOSYLHYDROXYLYSINE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 65 N-terminal" evidence="9">
        <location>
            <begin position="119"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 65 central catalytic" evidence="8">
        <location>
            <begin position="442"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ42509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1078" mass="120240" checksum="1CA27325C785F37A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YE27</accession>
    <name>C4YE27_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YE27"/>
    <dbReference type="PaxDb" id="5476-C4YE27"/>
    <dbReference type="HOGENOM" id="CLU_311219_0_0_1"/>
    <dbReference type="OMA" id="SFKMYND"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="809" mass="91493" checksum="DDD17DE398A80489" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YE34</accession>
    <name>MDM34_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial distribution and morphology protein 34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MDM34</name>
        <name type="ORF">CAWG_00785</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YE34"/>
    <dbReference type="SMR" id="C4YE34"/>
    <dbReference type="PaxDb" id="5476-C4YE34"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00785"/>
    <dbReference type="HOGENOM" id="CLU_476594_0_0_1"/>
    <dbReference type="OMA" id="PGCLERQ"/>
    <dbReference type="OrthoDB" id="17927at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21673">
        <property type="entry name" value="SMP_Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03105">
        <property type="entry name" value="Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027536">
        <property type="entry name" value="MDM34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058825">
        <property type="entry name" value="MDM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26545">
        <property type="entry name" value="Mdm34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0445">Lipid transport</keyword>
    <keyword id="KW-0446">Lipid-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1134">Transmembrane beta strand</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000384332" description="Mitochondrial distribution and morphology protein 34">
        <location>
            <begin position="1"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="442"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="572"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="622" mass="70115" checksum="60489BE132D3158B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YE72</accession>
    <name>C4YE72_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ERCC1-like central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_00825</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YE72"/>
    <dbReference type="SMR" id="C4YE72"/>
    <dbReference type="PaxDb" id="5476-C4YE72"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00825"/>
    <dbReference type="HOGENOM" id="CLU_041616_3_0_1"/>
    <dbReference type="OMA" id="HPEYIWQ"/>
    <dbReference type="OrthoDB" id="10262814at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000001">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="8">
        <location>
            <begin position="116"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="26"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ42608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="338" mass="37218" checksum="4C30F2A6589BEE6E" modified="2010-10-05" version="1">MSNTKDNANDIDASSFASILAGVQKMREDAGSIPSQDPTLAEVNHDTQPNASSLNAIQPPAPVPAPPPQTHTNVTNEKYQKATLNESTAKPIPPKRNNNSVKPSTKRTQTSGPSDILVSRSQEGNPLLSTPIMQATPWSFDKSLLSDYYINPKFQIIFLTLKYHKLHPEHIWNRWKKLNQGSSTVHTRGDDALRVLLVVVDVDSHQDLLRKLSDFCIKHDLSLVLAWSYEEAANYIALCKQLDKAPLKGRKIIEGTKGSDYNSSVVKAFTGIKSVNKTDVSNLLANCKSVKEIVLQSCQNDNDDGIGLASIPGLGAKKLENLKKVFSEPFISNKDYDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YE92</accession>
    <name>C4YE92_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="9">DMRL synthase</shortName>
            <ecNumber evidence="4 9">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_00846</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homopentamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 9"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YE92"/>
    <dbReference type="PaxDb" id="5476-C4YE92"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00846"/>
    <dbReference type="HOGENOM" id="CLU_089358_2_0_1"/>
    <dbReference type="OMA" id="CQGVTQG"/>
    <dbReference type="OrthoDB" id="2965at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.960:FF:000007">
        <property type="entry name" value="6,7-dimethyl-8-ribityllumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="entry name" value="Lumazine/riboflavin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058:SF0">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE DMRL SYNTHASE LUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="Lumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ42628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="182" mass="20399" checksum="B66AF065D244ADA9" modified="2009-07-28" version="1" fragment="single">SKIRWYVFYNSCSHKNSICPFNVHSITNILFPGSKLRIGILHARWNRKIIDALVAGAVKRLQEFGVKEENIIIETVPGSFELPYGSKLFVEKQKRLGKPLDAIIPIGVLIKGSTMHFEYICDSTTHQLMKLNFELGIPVIFGVLTCLTDEQAEARAGLIEGKMHNHGEDWGAAAVEMATKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEF5</accession>
    <name>C4YEF5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_00912</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cytoplasmic vesicle</location>
            <location evidence="13">COPI-coated vesicle membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the COPG family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEF5"/>
    <dbReference type="PaxDb" id="5476-C4YEF5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00912"/>
    <dbReference type="HOGENOM" id="CLU_010353_2_0_1"/>
    <dbReference type="OMA" id="DFIEDCE"/>
    <dbReference type="OrthoDB" id="1074925at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000368">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1480:FF:000001">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000008">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1480">
        <property type="entry name" value="Coatomer, gamma subunit, appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032154">
        <property type="entry name" value="Coatomer_g_Cpla"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017106">
        <property type="entry name" value="Coatomer_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013040">
        <property type="entry name" value="Coatomer_gsu_app_Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037067">
        <property type="entry name" value="Coatomer_gsu_app_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261:SF0">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16381">
        <property type="entry name" value="Coatomer_g_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08752">
        <property type="entry name" value="COP-gamma_platf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037093">
        <property type="entry name" value="Coatomer_gamma_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="15">
        <location>
            <begin position="22"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer gamma subunit appendage Ig-like subdomain" evidence="16">
        <location>
            <begin position="670"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer subunit gamma C-terminal" evidence="17">
        <location>
            <begin position="824"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="635"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="642"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR037093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ42691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="936" mass="104329" checksum="A120698BD90D060F" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEN2</accession>
    <name>NOP9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>Nucleolar protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Pumilio domain-containing protein NOP9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">NOP9</name>
        <name type="ORF">CAWG_00989</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOP9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEN2"/>
    <dbReference type="SMR" id="C4YEN2"/>
    <dbReference type="PaxDb" id="5476-C4YEN2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00989"/>
    <dbReference type="HOGENOM" id="CLU_008720_1_1_1"/>
    <dbReference type="OMA" id="CNSYGSH"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000407804" description="Nucleolar protein 9">
        <location>
            <begin position="1"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio 1">
        <location>
            <begin position="95"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio 2">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio 3">
        <location>
            <begin position="201"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio 4">
        <location>
            <begin position="285"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio 5">
        <location>
            <begin position="334"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio 6">
        <location>
            <begin position="374"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio 7">
        <location>
            <begin position="525"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio 8">
        <location>
            <begin position="567"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="651"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="657"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="715" mass="82775" checksum="FCDC01D123DE7FE3" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEQ1</accession>
    <name>C4YEQ1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SEC14 homolog 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_01009</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)</text>
            <dbReference type="Rhea" id="RHEA:38691"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:38692"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Microsome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEQ1"/>
    <dbReference type="PaxDb" id="5476-C4YEQ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01009"/>
    <dbReference type="HOGENOM" id="CLU_014001_1_1_1"/>
    <dbReference type="OMA" id="DIHARPC"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000013">
        <property type="entry name" value="Phosphatidylinositol transfer protein PDR16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0492">Microsome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="6">
        <location>
            <begin position="160"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00083195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ42787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="369" mass="42418" checksum="7ADFC7B5FAA89471" modified="2009-07-28" version="1">MFAKLRNKVSTPPPPVATTGSPTSSSSEITTTTNEKSSSTTSLSTVYIPFSTPSSESHIPSEPELTQEQKDKYLHVLNHFQQSDLKIAISEETHKHKQKTKELTIGEKSWITRECILRYLRATKWHESEAIDRIELTLSWRREFGISEPFDNENKVNGELVSEENETGKEVILGYDNDSRPCLYLKPGRQNTKTSERQVQHLVYMLERVIDYMPAGQDSLALLIDFKAHPVGTQSGKIPPVGIGRQVLHILQTHYPERLGKALLTNIPWLGWTFLKIIHPFIDPLTREKLVFDQPFINYVPKEQLDKDFEGLVNFEYDHKKYWDVMIKISQDKKHQYFERFEKFGGIVGLSEVDLRGNNEELIHPVGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF41</accession>
    <name>C4YF41_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit GON7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_01152</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GON7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF41"/>
    <dbReference type="PaxDb" id="5476-C4YF41"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01152"/>
    <dbReference type="HOGENOM" id="CLU_151420_0_0_1"/>
    <dbReference type="OMA" id="QDHLNIF"/>
    <dbReference type="OrthoDB" id="2288868at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014849">
        <property type="entry name" value="EKC/KEOPS_Gon7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08738">
        <property type="entry name" value="Gon7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ42927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="121" mass="13433" checksum="F6210D4D2708097B" modified="2009-07-28" version="1">MKLTPTAIYIAPDIDSPKHFHLSKNEDHSTNGKTTQISDIVIKAGGEDRDKPSDHKDTPLGNLRAELTTLQDHLNIFLTERMKLEKLKNGGGGGGGDNNKSNEQDLERRILDEGVEEEEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFA7</accession>
    <name>C4YFA7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar protein sorting-associated protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_01222</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the retromer complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFA7"/>
    <dbReference type="PaxDb" id="5476-C4YFA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01222"/>
    <dbReference type="HOGENOM" id="CLU_028982_1_0_1"/>
    <dbReference type="OMA" id="FYLGTME"/>
    <dbReference type="OrthoDB" id="9976382at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030905">
        <property type="term" value="C:retromer, tubulation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07625">
        <property type="entry name" value="BAR_Vps17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06891">
        <property type="entry name" value="PX_Vps17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014461">
        <property type="entry name" value="Retromer_complex_Vps17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053055">
        <property type="entry name" value="VPS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037907">
        <property type="entry name" value="Vps17_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011791">
        <property type="entry name" value="Vps17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="3">
        <location>
            <begin position="111"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Sorting nexin/Vps5-like C-terminal" evidence="4">
        <location>
            <begin position="242"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR011791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ42993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="519" mass="60016" checksum="3FDC61EEE275AE64" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFL1</accession>
    <name>C4YFL1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_01329</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFL1"/>
    <dbReference type="MEROPS" id="C19.079"/>
    <dbReference type="PaxDb" id="5476-C4YFL1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01329"/>
    <dbReference type="HOGENOM" id="CLU_017549_2_1_1"/>
    <dbReference type="OMA" id="RKVQFPF"/>
    <dbReference type="OrthoDB" id="333239at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02657">
        <property type="entry name" value="Peptidase_C19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF1">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="37"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="412" mass="46766" checksum="26AE9FAF0C994C29" modified="2009-07-28" version="1">MVLGTPDKNLPSKPVEKQVFLEDLNKNQLVKVSNEPSGLTNLGNTCYLNSSLQTIFHIDDVNNRLKNYTFGGANQANSAFVLSLKSMFQQMSKKQEVITPSTFLSLFRRSYPQFAEQQNGIYKQQDAEEAFSQILSSLRSELKIDDVFKITFNTKTQCLAIPEDVTEGFEEAYKLNCHIGVKTNFLRDGLLAGLKETIEKHNSTLNADTEYETTKTITRLPKYLTVHFIRFFWKRDINKKSKILRKVQFPFELDLAEMLDVSIKADKVSNRDTIRKVEKDNLDMIRDFKKTKNDTSLTPLEQQEEDEMKITSIKSKFKDDLNSALPNVDFNTTTENPSSVYELNAVITHAGSSADGGHYKAYVKDPTDLDGERWWLFNDDKVSSVNKEKIETLAGGGESDSALLLIYKGLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFL8</accession>
    <name>C4YFL8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_01336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFL8"/>
    <dbReference type="PaxDb" id="5476-C4YFL8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01336"/>
    <dbReference type="HOGENOM" id="CLU_685107_0_0_1"/>
    <dbReference type="OMA" id="RRDYIGM"/>
    <dbReference type="OrthoDB" id="4024719at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000805">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="405" mass="46071" checksum="3C4397E0883B2BD7" modified="2009-07-28" version="1">MARDLIKIEDFPEIMDGQKQGPRVGFCGLVVRFYPSRRDYIGMDVTDFTSHPRVCQNQEYYNGGLLLARNELLTIPVKIEALKRIQVSYPGIFGEQYNLAEEYYSASGVLDVHDKLLVVKMTLRTRLYQGFYEPYSYDEEIVDYEYLGNKDRLVVDDLFRNIVSRKEYFSKVSHLAPRLMPAKFLISTGHSSEVSDKVQHLNAISSVPDTKIKSPPHNSQYIHPPDPNTISSSPTQNLVPDIEHGDFDFCNSSTVGSPEEEQVFTISELKQLDMTIDNKTYMVSCKIIGCFPDDWMYLSGKEMDPKSNTAKDPIIRDLEWIIADANVDERTVLNSENTLSVISPAQDILEFSNYGSVEDFFIGCSGYRKKSNSIFNIPTKLEVRKIEIPINSSTTTVVWSPVESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFM5</accession>
    <name>C4YFM5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_01343</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Lipid-anchor</topology>
            <topology evidence="1 10">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFM5"/>
    <dbReference type="PaxDb" id="5476-C4YFM5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01343"/>
    <dbReference type="HOGENOM" id="CLU_021855_2_1_1"/>
    <dbReference type="OMA" id="QDHTECM"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030446">
        <property type="term" value="C:hyphal cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030445">
        <property type="term" value="C:yeast-form cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1040:FF:000005">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF2">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9 10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005125116" description="1,3-beta-glucanosyltransferase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="13">
        <location>
            <begin position="376"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="469"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ43106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="545" mass="58803" checksum="1F8C1A89CBB38B6D" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFN2</accession>
    <name>C4YFN2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_00008</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFN2"/>
    <dbReference type="PaxDb" id="5476-C4YFN2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00008"/>
    <dbReference type="HOGENOM" id="CLU_1147047_0_0_1"/>
    <dbReference type="OMA" id="MWSPHLF"/>
    <dbReference type="OrthoDB" id="10263353at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF16">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="6">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="5">
        <location>
            <begin position="123"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ41821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="242" mass="28043" checksum="C10391BF2ADAEB53" modified="2009-07-28" version="1" fragment="single">MSNPFSKRRRVDGEINREVLDFDFAKICSQTLSSTNVYACLMCGKYFEGRSPSSPAYKHAVSTNHQMYMSFATEKFYELPQDREVSPVQDVIDYYNPRYTPRDIDLLPRISFDLHKKYLVGYVGLNNIKKNDYANVVVQVLAHIEPVRNYYLLETPTNPLNVHLGLLIRKMWSPHLFKSHIAPHEFMNSVTEESKKRFTLEKGHPKSFLLWLLNRGGPYECLRGKVEVTSTPIVPHEGKDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFN4</accession>
    <name>C4YFN4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminopeptidase P N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_00010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFN4"/>
    <dbReference type="MEROPS" id="M24.A09"/>
    <dbReference type="PaxDb" id="5476-C4YFN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00010"/>
    <dbReference type="HOGENOM" id="CLU_017266_1_2_1"/>
    <dbReference type="OMA" id="DAHALFF"/>
    <dbReference type="OrthoDB" id="10261878at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000002">
        <property type="entry name" value="Xaa-Pro aminopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF1">
        <property type="entry name" value="XAA-PRO DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="6">
        <location>
            <begin position="7"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ41823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="450" mass="51280" checksum="8A41FF108B304B9F" modified="2009-07-28" version="1">MTTPSKYPARSHARKVYSHIKAPFFISGEDLVLYKYCDQTKPFRQNRYFFYLTGCNIPGSHVLYTHDKLVLYLPDVDHEDIMWSGLPLSPEQALAKYDVDEVKFAADIESDLKNLGTVYTTDTSHPHLKPYLTESDPAFFFALDESRLIKDDYEIELMRHAAKITDNCHLAVMSALPIETKETHIHAEFMYHALRQGAKNQSYDPICCSGETCSTLHWVKNDGDITPEKRSVLIDAGAEWECYASDVTRCFPVNGDWAKEHLEIYNLVLKMQSAAYDMMKPGVEWEDIHLQAHKVLIQGFLELGIFNSKYSAEELFAAKASARFFPHGLGHVLGMDTHDVGGRANYSDPDPLLCYLRIRRKLEPNMVVTNEPGCYFSPFLLEEVLNNPGQAKFINRDVLDKYWYVGGVRIEDDVLITPTGYEIFTKITKDPAEISKIVKAGLAKKFHNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFP0</accession>
    <name>C4YFP0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_00016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFP0"/>
    <dbReference type="PaxDb" id="5476-C4YFP0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00016"/>
    <dbReference type="HOGENOM" id="CLU_434755_0_0_1"/>
    <dbReference type="OMA" id="SFEQYIY"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ41829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="599" mass="69951" checksum="5C83A1F7F89F4030" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFP2</accession>
    <name>C4YFP2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_00018</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFP2"/>
    <dbReference type="PaxDb" id="5476-C4YFP2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00018"/>
    <dbReference type="HOGENOM" id="CLU_024893_2_1_1"/>
    <dbReference type="OMA" id="CPGYKDQ"/>
    <dbReference type="OrthoDB" id="2537459at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ41831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="444" mass="46750" checksum="F65590E365FE4166" modified="2009-07-28" version="1">MSNGLCRDTCSKDGYAVAVLSGNDCYCTNDVPADTTDMSNCEIGCPGYKDQENCAGDGYFGYLIIGQPSATVGGETSTSKSTQSSTSTSTSTSSTSTSSTTSSSSSTSTTSSSSSTSTSTTSEPSSSISPATTMVTKTTQITETHRSSNIVQVTQYSTEVLTVSPSTTSKSSTSSSSKSSSQTPIVSTKIEQTTAYSIKTVNGTQTQEIKTLYITQFTTQSTSDSTTGTTSFESASISNLRSQDASVAPTSSVSSSSTTDSPKTNKNAFFDDKGKVAGTFTAVGIVVVGIVGAMLYCCCCFGGAGGRHNDHDGYSDEENQYSSDELSVNHATVVAPYSKQSSFSTLKRDSSSKTLFAYFTGDNTNKESGVNRSSSRRKLMSRRSSQMSSSPNNNPEADGGAMFPINEIDSRLDPDTMFLNQNFSNKSLGDNQDYSRKLKITNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFP9</accession>
    <name>C4YFP9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-activated protein kinase glycogen-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_00025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFP9"/>
    <dbReference type="PaxDb" id="5476-C4YFP9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00025"/>
    <dbReference type="HOGENOM" id="CLU_032652_0_0_1"/>
    <dbReference type="OMA" id="TFDNWTK"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF94">
        <property type="entry name" value="MDG1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-activated protein kinase glycogen-binding" evidence="2">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ41838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="592" mass="63432" checksum="1CABE0352D1AEB99" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFZ6</accession>
    <name>C4YFZ6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">5'-3' exoribonuclease 1</fullName>
            <ecNumber evidence="10">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_00109</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the 5'-3' exonuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="10"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YFZ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00109"/>
    <dbReference type="HOGENOM" id="CLU_001581_1_2_1"/>
    <dbReference type="OMA" id="VASWPWF"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016078">
        <property type="term" value="P:tRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000001">
        <property type="entry name" value="5'-3' exoribonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.750:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016494">
        <property type="entry name" value="5_3_exoribonuclease_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047007">
        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006743">
        <property type="entry name" value="Exonuclease_Xnr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="3 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="13">
        <location>
            <begin position="191"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="15">
        <location>
            <begin position="651"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="16">
        <location>
            <begin position="843"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="14">
        <location>
            <begin position="1087"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1190"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1281"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1329"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1203"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1231"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1242"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1286"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1331"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1346"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1367"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1394"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1413"/>
            <end position="1422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ41920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1422" mass="162995" checksum="20C2A1540223F131" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG68</accession>
    <name>C4YG68_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Meiotic recombination protein DMC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_00186</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecA family. DMC1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YG68"/>
    <dbReference type="PaxDb" id="5476-C4YG68"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00186"/>
    <dbReference type="HOGENOM" id="CLU_041732_0_0_1"/>
    <dbReference type="OMA" id="ANPMKPV"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19514">
        <property type="entry name" value="DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000239">
        <property type="entry name" value="Meiotic recombination protein DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011940">
        <property type="entry name" value="Dmc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02238">
        <property type="entry name" value="recomb_DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF30">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN DMC1_LIM15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="10">
        <location>
            <begin position="112"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="11">
        <location>
            <begin position="290"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ41992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="353" mass="38692" checksum="A10A943690496DB4" modified="2009-07-28" version="1">MSVEDSIISIDSLQDQGINAGDINKLKSAGICSITVRIIKFTSCSFSDHSVLSTTRRNLTKIKGLSEIKVEKIKEAAGKIKVCKNLFVLICFNPRQKYGFLPATIVAELRTKVFHITTGSKQFNEILGGGIQSMSITEVFGEFRCGKTQLCHTLCVAAQLPTDMGGGEGRVAYIDTEGTFRPDRIRSIAERYGVDADTCLENISYARALNSEHQIELVEQLGNELAEGTFRLLIVDSIMACFRVDYSGRGELNERQQKLNQHLSNLTRVAEDYNIAVFLTNQVQSDPGASALFAAADGRKPVGGHVLAHASATRILLRKGRGEERVAKLQDSPNMPEKECVYVIGEGGIKDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGA9</accession>
    <name>C4YGA9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_00230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGA9"/>
    <dbReference type="PaxDb" id="5476-C4YGA9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00230"/>
    <dbReference type="HOGENOM" id="CLU_000288_5_10_1"/>
    <dbReference type="OMA" id="FRGHMCI"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14210">
        <property type="entry name" value="PKc_DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF22">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="378"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ42033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="732" mass="84129" checksum="B3EC16AF0DBF3188" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGJ5</accession>
    <name>C4YGJ5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Hyphally-regulated cell wall protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_03173</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HYR1/IFF family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YGJ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03173"/>
    <dbReference type="HOGENOM" id="CLU_006199_1_0_1"/>
    <dbReference type="OMA" id="CEECTEY"/>
    <dbReference type="OrthoDB" id="4022214at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031573">
        <property type="entry name" value="Cell_wall_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021031">
        <property type="entry name" value="Hyphal-reg_cell_wall_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11765">
        <property type="entry name" value="Hyphal_reg_CWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15789">
        <property type="entry name" value="Hyr1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 14" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946461" description="Hyphally-regulated cell wall protein N-terminal domain-containing protein" evidence="14">
        <location>
            <begin position="21"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="domain" description="Hyphally-regulated cell wall protein N-terminal" evidence="15">
        <location>
            <begin position="12"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF11765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEQ44877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1308" mass="136884" checksum="2676E8D66F0C7D2A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGZ0</accession>
    <name>C4YGZ0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_03331</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGZ0"/>
    <dbReference type="PaxDb" id="5476-C4YGZ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03331"/>
    <dbReference type="HOGENOM" id="CLU_014727_1_0_1"/>
    <dbReference type="OMA" id="KDHTHIH"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000661">
        <property type="entry name" value="paternally-expressed gene 3 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001465">
        <property type="entry name" value="Zinc finger protein 560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="473"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="502"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="530"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="558"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="586"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ45022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="612" mass="69996" checksum="864847E8DDB10E67" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHK1</accession>
    <name>C4YHK1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_03548</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHK1"/>
    <dbReference type="PaxDb" id="5476-C4YHK1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03548"/>
    <dbReference type="HOGENOM" id="CLU_035750_1_0_1"/>
    <dbReference type="OMA" id="CSGCWCD"/>
    <dbReference type="OrthoDB" id="268479at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03757">
        <property type="entry name" value="proteasome_beta_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000027">
        <property type="entry name" value="Proteasome subunit beta type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ45233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="244" mass="27139" checksum="F44CEA41C2EC82E5" modified="2009-07-28" version="1">MSSVQTTVASEYSSEIQTVPIEHRFNPYSDNGGTVLGIAGEDFAVLAGDTRQVEGYSIQSRYESKIHDVGDDILMTANGFAADGVALIDRFKQSLIWYKFDNNGKKLAIKSAARYIQQLLYGKRFFPYVSTLIAGLDEEGKGAVYSYDPVGSYEREQCRAAGAAASLIMPFLDNQVNFKNQFVPGTDGKEKKPLKFLTLEEVIQLVRDAFTSAGERHIYVGDGLEIKIVTKDGIRTEYYPLKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHP3</accession>
    <name>C4YHP3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Carnitine O-acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="16">2.3.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CAWG_03592</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-carnitine + acetyl-CoA = O-acetyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:21136"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57589"/>
            <dbReference type="EC" id="2.3.1.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.7" evidence="16"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHP3"/>
    <dbReference type="PaxDb" id="5476-C4YHP3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03592"/>
    <dbReference type="HOGENOM" id="CLU_013513_5_1_1"/>
    <dbReference type="OMA" id="KMDGTPT"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000007">
        <property type="entry name" value="Carnitine O-acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF103">
        <property type="entry name" value="CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 19" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="20">
        <location>
            <begin position="49"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EEQ45275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="632" mass="71373" checksum="6E8A38C6F4A89CAC" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI23</accession>
    <name>C4YI23_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">histidinol-phosphate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_03730</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="4"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI23"/>
    <dbReference type="PaxDb" id="5476-C4YI23"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03730"/>
    <dbReference type="HOGENOM" id="CLU_017584_3_1_1"/>
    <dbReference type="OMA" id="NFVQFGR"/>
    <dbReference type="OrthoDB" id="2015537at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885:SF2">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="28"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ45405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="388" mass="43165" checksum="679EC30BC800D8B9" modified="2009-07-28" version="1">MFDISAIIRPNILTLEPYRCARDDFKTGILLDANENTHGPLPSPDANEAALELNRYPDPHQHELKQQIIQFREQHPNKYATEKLSIENLCLGVGSDESIDMLLRCVCVPGKDKMLICPPTYGMYSICATVNDVAIEKVPLTIPDFQIDIDGILTKVKSDPTIKLLYLTSPGNPTGKLIDVEDIIKLLKESLKAWQGLIVVDEAYIDFTKPGSSMSTLVNQYPNLVVLQTLSKSFGLAGIRLGITFSSKQLSWYLNAMKYPYNISSLTSNVAIKATNKGLSVMENYVSKIVEQRELVLEKLLSLKYVGRNIGGLDSNFILIEILDKDGKPSNDVAKKLYNTLATDNSVVVRYRGSELNCVGGLRISIGTSEENKQMLTKFESVLNEINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI28</accession>
    <name>C4YI28_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_03736</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI28"/>
    <dbReference type="PaxDb" id="5476-C4YI28"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03736"/>
    <dbReference type="HOGENOM" id="CLU_011811_0_0_1"/>
    <dbReference type="OMA" id="PRWKKCP"/>
    <dbReference type="OrthoDB" id="302966at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000595">
        <property type="entry name" value="MAG2p Cytoplasmic protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="166"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="557"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="461"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="572"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="590"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ45410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="603" mass="69791" checksum="F4696B531099DFB8" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI81</accession>
    <name>C4YI81_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL28m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_04153</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI81"/>
    <dbReference type="PaxDb" id="5476-C4YI81"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04153"/>
    <dbReference type="HOGENOM" id="CLU_090033_0_0_1"/>
    <dbReference type="OMA" id="VQRDSYY"/>
    <dbReference type="OrthoDB" id="361870at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.40:FF:000003">
        <property type="entry name" value="54S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="entry name" value="Ribosomal protein L28/L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribosomal_bL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="Ribosomal_bL28/bL31-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribosomal_bL28_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="L28p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ45816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="265" mass="31422" checksum="F1AE37D0AAB31CAF" modified="2009-07-28" version="1">MNVFRGLISIPHISCVSQIYSARQLSSTLPLSTKRTYDKFYKITKQLQPIDKNVYEIGQERPDNISIPKDLPEFPKYEYEPRFFKRQNRGLYGGLQRKRSKSCSEYLNKTLRAHRPNAQWTKLWSETLNRRLRLRVATRVLKTISKEGGLDQYLLKSTPARVKTMGLKAWQLRYRILQEREQKQRGNVTLSDGTTKPIQYISSNGLKFHATKDAMLSELYEAVQRDSYYPIKPFHFERDYSWLSYEEIVKKLEQYNWDFSELATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI93</accession>
    <name>C4YI93_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI93"/>
    <dbReference type="PaxDb" id="5476-C4YI93"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04165"/>
    <dbReference type="HOGENOM" id="CLU_445499_0_0_1"/>
    <dbReference type="OMA" id="MMDDDAM"/>
    <dbReference type="OrthoDB" id="4095451at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="687" mass="79389" checksum="17F71E14C051B247" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIA3</accession>
    <name>C4YIA3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-aminobutyrate aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GABA aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Gamma-amino-N-butyrate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_04175</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23352"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="2.6.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer and homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="4"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIA3"/>
    <dbReference type="SMR" id="C4YIA3"/>
    <dbReference type="PaxDb" id="5476-C4YIA3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04175"/>
    <dbReference type="HOGENOM" id="CLU_016922_12_0_1"/>
    <dbReference type="OMA" id="ERIMTTW"/>
    <dbReference type="OrthoDB" id="10260828at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000029">
        <property type="entry name" value="4-aminobutyrate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004631">
        <property type="entry name" value="4NH2But_aminotransferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00699">
        <property type="entry name" value="GABAtrns_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF1">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ45838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="471" mass="52662" checksum="1574B63FD0EEB711" modified="2010-10-05" version="1">MSSKSVSSLYFPEEPKEPVVVDSHAKSKEIADRLGKVFDNRGVYFVADYEKSVGNYIADVDGNVYLDVYAQIASIPLGYNNPALIETAKSDKMIRAIVDRPAIGNFPGKDTDEIVSEILKVAPKGQDKVWSGLSGADANELAFKAAFFYYQAKKRGYTTQFSEEEMKSVMQNEAPGSPELAILSFERGFHGRLFASGSTTCSKPIHKLDMPSFKWPKAQFPSYKYPLDKYAEENKKEDERCLKIVDDIIQNNKIPVAAVLVEPIQSEGGDNHASAEFFQGLRDITLKHGSLLIMDEVQTGVGATGVMWAHERFNLQPPPDLVTFSKKFQSAGYFFHDPEIIPNFAYRQFNTWCGDPARMILAGAIGQEILKHDLVKRAAEVGDYLFKKLEQLQEKYPKYIKDLRGKDRATFIAWSLESGEARNKFLSDMKTVGVNIGGCAEDSVRLRPTLVFEEQHADILVSAIDKLLGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIZ5</accession>
    <name>C4YIZ5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_03807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIZ5"/>
    <dbReference type="PaxDb" id="5476-C4YIZ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03807"/>
    <dbReference type="HOGENOM" id="CLU_084558_0_0_1"/>
    <dbReference type="OMA" id="TIGWAPL"/>
    <dbReference type="OrthoDB" id="2103474at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="MEMBRANE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519:SF1">
        <property type="entry name" value="YALI0C06193P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ45479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="235" mass="26160" checksum="2A3403B4D63A7E33" modified="2009-07-28" version="1">MSQIQDQLENIPGYDVVMDYFNEYGEEHWNAKVNPFEDENGNKRRLPKDLATKHDQQVWKQIQSQAWTDDKCFLGSCAVGLDCGLGLAPLVVLIFPVLGPLIMYGVHTRVINIAQKNYNLPNTLIAKLQTNIMIDLLITFPPVIGSFFGWLHACSTRNAGMIYIYLEKMLKHKVSGQGVSYVGARMTAGTYEGQPNAGSSVQGSRPQTVKSTGLFKKKPTTNNSIRVGQQESGFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ02</accession>
    <name>C4YJ02_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">aromatic-amino-acid transaminase</fullName>
            <ecNumber evidence="9">2.6.1.57</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_03814</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2019" name="J. Struct. Biol." volume="205" first="26" last="33">
            <title>Crystal structures of aminotransferases Aro8 and Aro9 from Candida albicans and structural insights into their properties.</title>
            <authorList>
                <person name="Kiliszek A."/>
                <person name="Rypniewski W."/>
                <person name="Rzad K."/>
                <person name="Milewski S."/>
                <person name="Gabriel I."/>
            </authorList>
            <dbReference type="PubMed" id="30742897"/>
            <dbReference type="DOI" id="10.1016/j.jsb.2019.02.001"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH PYRIDOXAL 5'-PHOSPHATE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an aromatic L-alpha-amino acid + 2-oxoglutarate = an aromatic oxo-acid + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:17533"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:73309"/>
            <dbReference type="ChEBI" id="CHEBI:84824"/>
            <dbReference type="EC" id="2.6.1.57"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.57" evidence="9"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PDB" id="6HNB">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.96 A"/>
        <property type="chains" value="A/B=1-491"/>
    </dbReference>
    <dbReference type="PDB" id="6HNU">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.80 A"/>
        <property type="chains" value="A/B=1-491"/>
    </dbReference>
    <dbReference type="PDBsum" id="6HNB"/>
    <dbReference type="PDBsum" id="6HNU"/>
    <dbReference type="AlphaFoldDB" id="C4YJ02"/>
    <dbReference type="SMR" id="C4YJ02"/>
    <dbReference type="PaxDb" id="5476-C4YJ02"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03814"/>
    <dbReference type="HOGENOM" id="CLU_017584_0_5_1"/>
    <dbReference type="OMA" id="FMPGEPF"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008793">
        <property type="term" value="F:aromatic-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000074">
        <property type="entry name" value="Aromatic amino acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF21">
        <property type="entry name" value="AROMATIC_AMINOADIPATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="14 15" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="11">
        <location>
            <begin position="76"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ45486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="6HNB"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="6HNU"/>
        </source>
    </evidence>
    <sequence length="491" mass="54778" checksum="F4DB998855FDB382" modified="2009-07-28" version="1">MTSDTKPQAKDLTHLLSNESKARQTSPLKGIFKYYKQPGITFLGGGLPLSDYFPFEKVTADIPTPSFSGGIGAPIEGENKTTIEVFKKAADNVPDQIELARSLQYGSTFGSPEFLQFIKEHTDMVHKVPYENWDVIVSVGNTEAWDSTLRTFCSKGDTILVEEYTFSSALESANGQGVNTVPVTMDEFGIIPEKLEELMSRWVGNKPKFLYTICTGQNPTGSSLSAERRKQIYDIACKYDFLIIEDEPYYFLQMETYTKDKAAREGKAVHDHDEFLKALVPSFISLDVEGRVVRLDSFSKVLAPGLRLGWIVGQKDLLERYVRLHEVSVQNPSGFSEALANALLRKWGHSGYLDWLIGLRAEYTHKRDVAIDALDQFVPKEVSSFNPPVAGMFFTVTLDASKHPKYKEFLEDPLKVEAAVHEQAIKQGCLLAPGSWFKAEGQSSPPQKNLPANPSHKTHIFFRGTYAAVPLDQLVVGLEKFGKAVRAEFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ85</accession>
    <name>C4YJ85_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_03898</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ85"/>
    <dbReference type="PaxDb" id="5476-C4YJ85"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03898"/>
    <dbReference type="HOGENOM" id="CLU_041456_0_1_1"/>
    <dbReference type="OMA" id="QFFGQHY"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000052">
        <property type="entry name" value="Prolyl 4-hydroxylase alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF236">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="140"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ45569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="251" mass="29110" checksum="D87BB486FA470637" modified="2009-07-28" version="1" fragment="single">LHTFYLPFILSLSMPPKKKSSKTIYKFPQSFHDLPKSLSKNYYQPEPESIINDQIIIIKNFFNKDLCNELIKSFETQLNMETTPLIKSKEYAARFNDRSSMNDLLSANILWQYLQKILLDNPYNDEDLNEINQIFQDAVGLNPQLRVYRYTRGHHFGKHYDDSVICPIPPQGTKKGYTKWTLLIYLTGDEEFKGGGTIFYPEIKNIKPLNIHPNKGMALLHKHGVDCLKHEAEMVANGAKWVLRSDVVFPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJA6</accession>
    <name>C4YJA6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_03919</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YJA6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03919"/>
    <dbReference type="HOGENOM" id="CLU_242296_0_0_1"/>
    <dbReference type="OMA" id="FSRELWC"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009401">
        <property type="entry name" value="Med13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051139">
        <property type="entry name" value="Mediator_complx_sub13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021643">
        <property type="entry name" value="Mediator_Med13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041285">
        <property type="entry name" value="MID_MedPIWI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249:SF3">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06333">
        <property type="entry name" value="Med13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11597">
        <property type="entry name" value="Med13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18296">
        <property type="entry name" value="MID_MedPIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med13 N-terminal" evidence="14">
        <location>
            <begin position="5"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="MID" evidence="15">
        <location>
            <begin position="1082"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit Med13 C-terminal" evidence="13">
        <location>
            <begin position="1281"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="411"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="482"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="551"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="619"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="673"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="415"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="551"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="682"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="728"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEQ45590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1665" mass="186824" checksum="FF716A77772CCBF9" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJH1</accession>
    <name>C4YJH1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enhancer of mRNA-decapping protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_03986</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the EDC family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJH1"/>
    <dbReference type="PaxDb" id="5476-C4YJH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03986"/>
    <dbReference type="HOGENOM" id="CLU_097606_0_0_1"/>
    <dbReference type="OMA" id="NGNKNHH"/>
    <dbReference type="OrthoDB" id="4026794at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028322">
        <property type="entry name" value="PNRC-like_rgn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15365">
        <property type="entry name" value="PNRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
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        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00061292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ45655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="27940" checksum="F2400359ADAA8363" modified="2009-07-28" version="1">MLAQQQPPTPTPQQSQPQPQQMSQSRKSKSKKKQSYYDEEVRTLPSGAPVDFGHGKKSTSKPKSKSKPASSSTTNFKLTASPSLPSGAKPNFQPYKSTSPPPPPPSTQPSTSTSPTPRTSNGNKNHHNRHQSNHSDYDNDHPQLSLPNGKKPNFFNNNNNNNDKKFSTIPFDSSINLIRKQYNNPNTKAIKEKKLDNNNNNNSNSNNSNNSNNSNSAYYAGSSFHSSPDALNLPKPSFKSNNGSPRQSSGLRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJI5</accession>
    <name>C4YJI5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="8">PPIase</shortName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_04000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJI5"/>
    <dbReference type="SMR" id="C4YJI5"/>
    <dbReference type="PaxDb" id="5476-C4YJI5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04000"/>
    <dbReference type="HOGENOM" id="CLU_012062_4_2_1"/>
    <dbReference type="OMA" id="TWLTGKH"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000032">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="10">
        <location>
            <begin position="30"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ45670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="191" mass="20979" checksum="FEAB7D9C3C59F580" modified="2010-10-05" version="1">MFKTTLTKPLTFKSARFFSTTPRAWGTKVFFNTSINGEKQPPITFELYDDVTPITAENFRVLCTGEKGVGYKGSIFHRIIPQFMLQGGDFETGKGYGGYSPTHNNDKFNDENFIKKHDRPGLLSMANAGPNTNGSQFFITTVPCPWLDGKHVVFGEVVDGFDVVKKIESCGTSSGTPSASVVIEESGEAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJK4</accession>
    <name>C4YJK4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_04019</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="2"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJK4"/>
    <dbReference type="SMR" id="C4YJK4"/>
    <dbReference type="PaxDb" id="5476-C4YJK4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04019"/>
    <dbReference type="HOGENOM" id="CLU_033546_4_0_1"/>
    <dbReference type="OMA" id="YFGWARQ"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008361">
        <property type="term" value="P:regulation of cell size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF48">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="11">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ45688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="320" mass="35054" checksum="B26BB74103621D65" modified="2010-10-05" version="1">MSTNSIKLLASDVHRGLAELVSKRLGLRLTPSELKRESTGEVQFSIGESVRDEDIFIICQIGSGEVNDRVFELMIMINACKTASARRITVILPNFPYARQDRKDKSRAPITAKLMADMLTTAGCDHVITMDLHASQIQGFFDVPVDNLYAEPSVVRYIKETIDYSEAIIISPDAGGAKRAAGLADRLDLNFALIHKERARANEVSRMVLVGDVTDKICVIVDDMADTCGTLAKAAEVLLDNNAKDVIAIVTHGILSGNAIKNINNSKLKKVVCTNTVPFEDKLKLCPKLDTIDISAVIAESIRRLHNGESISYLFKNAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJN1</accession>
    <name>C4YJN1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_04049</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJN1"/>
    <dbReference type="PaxDb" id="5476-C4YJN1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04049"/>
    <dbReference type="HOGENOM" id="CLU_066247_11_3_1"/>
    <dbReference type="OMA" id="RDAKFKK"/>
    <dbReference type="OrthoDB" id="601405at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22905">
        <property type="entry name" value="HFD_Dr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000019">
        <property type="entry name" value="Negative cofactor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042225">
        <property type="entry name" value="Ncb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138:SF1">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="3">
        <location>
            <begin position="13"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ45715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="149" mass="16903" checksum="BFA460A2B2BA030E" modified="2009-07-28" version="1">MSEYSGSNSEDLSLPKATVQKIINEILPKDIGIAKEAREAITECSIEFIMMLSTQSNDIAEKEAKKTIASDHVVKALEELDFKIYLDIINKILDEHKELLKGKEKRNNKFQNSGLTEEELLRQQEELFKKSRARLQNQSGSPTAKPEPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJX3</accession>
    <name>C4YJX3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="1">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04144</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="1"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJX3"/>
    <dbReference type="PaxDb" id="5476-C4YJX3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04144"/>
    <dbReference type="HOGENOM" id="CLU_010289_2_1_1"/>
    <dbReference type="OMA" id="HCRLAQS"/>
    <dbReference type="OrthoDB" id="686384at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06155">
        <property type="entry name" value="eu_AANH_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06156">
        <property type="entry name" value="eu_AANH_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000145">
        <property type="entry name" value="ATP-binding domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1490.10:FF:000003">
        <property type="entry name" value="Diphthine--ammonia ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ45807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="627" mass="70865" checksum="3B07A2787E019082" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJZ0</accession>
    <name>C4YJZ0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_05782</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJZ0"/>
    <dbReference type="PaxDb" id="5476-C4YJZ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05782"/>
    <dbReference type="HOGENOM" id="CLU_005476_0_0_1"/>
    <dbReference type="OMA" id="SYYMHTY"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008796">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004780">
        <property type="term" value="F:sulfate adenylyltransferase (ADP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <source>
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        <source>
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        <source>
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        </source>
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    <sequence length="1159" mass="126803" checksum="3D2806B0FAEE76DE" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK21</accession>
    <name>C4YK21_CANAW</name>
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        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
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        <name evidence="15" type="ORF">CAWG_05816</name>
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    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
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        <subcellularLocation>
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    </comment>
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ47250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="112" mass="12876" checksum="292DDDF39F5FFEF0" modified="2010-10-05" version="1">MASFRFCAECNNMLYPKEDKEGQRLLYACRNCGYTELAENPKVYRHELMTNIGATAGVVEDIGNDPTLPRSDKECPDCGHHECVFFQSQQRRKDTSMILFFVCLNCKHVFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK30</accession>
    <name>C4YK30_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="10">DOHH</shortName>
            <ecNumber evidence="10">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LIA1</name>
        <name evidence="12" type="ORF">CAWG_05825</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="10">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="10"/>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK30"/>
    <dbReference type="SMR" id="C4YK30"/>
    <dbReference type="PaxDb" id="5476-C4YK30"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05825"/>
    <dbReference type="HOGENOM" id="CLU_053974_0_0_1"/>
    <dbReference type="OMA" id="LQEPCSI"/>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000099">
        <property type="entry name" value="Deoxyhypusine hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000292">
        <property type="entry name" value="Deoxyhypusine hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="11">
        <location>
            <begin position="245"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ47259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="318" mass="35802" checksum="1A1060D38E2A62EB" modified="2009-07-28" version="1">MSADEVNIDTASLEELRDILINKTGNTKLANRFRALFNLKSVGSEDSDKERAHKAIKYIAECFNDDSELLKHEVAYVLGQTKDLYAAPYLREVLENDNQQCMVRHEAAEALGALGDKESLPLLEKYFKEDPLLEIRQTCELAIERIHWENSEKAKNEVLEKSLYTSIDPAPPLATNDSTSKVEKLKEILNDQDKPLFERYRAMFRLRDIGTDEACLALASGFDDPSALFKHEIAYVFGQMCNPVTVPSLIKVLKDESEAGMVRHEAAEALGSIATDECLPVLQSFLNDSEPVVRDSAIVALDMYEYENSNELEYATVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKE5</accession>
    <name>C4YKE5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA polymerase II-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_05947</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKE5"/>
    <dbReference type="PaxDb" id="5476-C4YKE5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05947"/>
    <dbReference type="HOGENOM" id="CLU_021991_1_1_1"/>
    <dbReference type="OMA" id="LVCRIKY"/>
    <dbReference type="OrthoDB" id="10260285at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007133">
        <property type="entry name" value="RNA_pol_II-assoc_Paf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188:SF12">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03985">
        <property type="entry name" value="Paf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="416"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="431"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ47374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="54850" checksum="798BC0B0E1298719" modified="2009-07-28" version="1">MSSNKSSKPIRQDYIAKVRYTNNLPPPPLNPKFIEYNTTDPISTQQEGEYLISSLFRKENFQNLMERIDDQLGLDLNLINNRGFLSEDKMNESVGKLKYNQLHPNDRALLRDAGIGKISKNEPEVSFLRRTEYISDRPLSKGGNNLNTATEEIKVKEKLSKDEHFDADSQLQNVEESFTVANEALYDLKNIKHPKKKHLRAVNTWPLLPDTSMLDNVFLNLRFMGSASINRELNNLKQQQQQQEQNDKKFDEKLFDRALESSLFKPIKSEGGEWISMYSLDATNTSTTANDNDNEEQINDLYEKLHSTKKEQPINLLDEDEESLETYKFKYTKNYDMTYQPFEHENEELAIKFVSDEIEDPVSKGNFKRKRKMAYYYPINGKIELKKHRASTNSEINKFIKERTYDGINFILREPSTNELKRSDTIRSEYDPMEYEGEDEEEEEEEEEEEEQQEEEQQQQEVETKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKF6</accession>
    <name>C4YKF6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKF6"/>
    <dbReference type="PaxDb" id="5476-C4YKF6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05958"/>
    <dbReference type="HOGENOM" id="CLU_017271_0_0_1"/>
    <dbReference type="OMA" id="TINECKP"/>
    <dbReference type="OrthoDB" id="10265467at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051314">
        <property type="entry name" value="AAA_ATPase_RarA/MGS1/WRNIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779:SF7">
        <property type="entry name" value="ATPASE WRNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779">
        <property type="entry name" value="WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="60"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ47385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="552" mass="63170" checksum="C8FA20D0243C6BAF" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKJ0</accession>
    <name>C4YKJ0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">inositol phosphorylceramide mannosyltransferase</fullName>
            <ecNumber evidence="8">2.4.1.370</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_05994</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose = an alpha-D-mannosyl-(1&lt;-&gt;6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:64596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:155885"/>
            <dbReference type="ChEBI" id="CHEBI:155926"/>
            <dbReference type="EC" id="2.4.1.370"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:64597"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.370" evidence="8"/>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKJ0"/>
    <dbReference type="PaxDb" id="5476-C4YKJ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05994"/>
    <dbReference type="HOGENOM" id="CLU_036369_3_2_1"/>
    <dbReference type="OMA" id="EYLFYSW"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103064">
        <property type="term" value="F:inositol phosphorylceramide mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006676">
        <property type="term" value="P:mannosyl diphosphorylinositol ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000001">
        <property type="entry name" value="MIPC synthase subunit (SurA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF20">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE CSH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="351"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="441"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="378"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="473"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ47419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="542" mass="61635" checksum="51532C6B1C42F327" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKT9</accession>
    <name>C4YKT9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">calcium/calmodulin-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CAWG_06097</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.17" evidence="2"/>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKT9"/>
    <dbReference type="PaxDb" id="5476-C4YKT9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06097"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="OMA" id="HDWFESR"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000449">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000278">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="35"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="356"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="420"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EEQ47518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="477" mass="53748" checksum="0BF345584BEACFBF" modified="2009-07-28" version="1">MSTDHHSHPVEGHQFKKIFNRLSGQPESYSRKQNYTFGKTLGAGSFGIVRYARDNSTDEEVAVKIILKKALKGNESMIIDEMQLLEQLNSPHIVGFRDWFESKDKFYLVTQLATGGELFDRIVQKGRFTEHDASLVVLQMLEALEYLHNKDIVHRDIKPENILYLTSKDDSPIVLADFGIAKRLQNPNEKLTSSAGSFGYAAPEVILGTGHGKPCDIWSLGVVTYTLLCGYSPFRSENVQDFINEVKHNNAVIFHADYWKDVSKDARRFIIKALQFNPDNRPTATELLNDPWLVSIAKEYKETDLLPNFKQGFDAKKKFRQAIELVKLNNRIKKLKEWQTDEDDDPTEINLFNEHGSVEQRANPSTNDGLTIPGTTSPRRGESPLNTWKKFNDVINSLDTNRSKASLSSFKSPYDLAHSNRGTDVSNSGATNVGKSDTASSAFVQLVHAATANKEKVANYTEDEEGKEKKQKDGDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKY1</accession>
    <name>C4YKY1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">UDP-N-acetylglucosamine transferase subunit ALG14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Asparagine-linked glycosylation protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ALG14</name>
        <name evidence="12" type="ORF">CAWG_06140</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterodimer with ALG13 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKY1"/>
    <dbReference type="PaxDb" id="5476-C4YKY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06140"/>
    <dbReference type="HOGENOM" id="CLU_064541_2_0_1"/>
    <dbReference type="OMA" id="CRIVFIE"/>
    <dbReference type="OrthoDB" id="17098at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154:SF4">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ47560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="219" mass="24494" checksum="AED3C81078247641" modified="2009-07-28" version="1">MDIETAACFSIAFIATPILIVLVRLLFILPSLRLPTSVKKKKKLIQECQLSILLGSGGHTGEMMRIISKLDMGKVSRTWIYTSGDNASLAKAQDYERKSGTSSQYIPIPRARTVGQSYISSIPTTIYSFLFSAIAMLKHRPAVILLNGPGTCVPVAYILFFYKLLGLCNTKIIYIESLARVNKLSLSGLLLLPISDRFIVQWESLYQQYSRVEYYGILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLH5</accession>
    <name>C4YLH5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_01693</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLH5"/>
    <dbReference type="SMR" id="C4YLH5"/>
    <dbReference type="PaxDb" id="5476-C4YLH5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01693"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_4_1"/>
    <dbReference type="OMA" id="AIMYNMS"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ43456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="376" mass="41736" checksum="77670401B0B199FF" modified="2010-10-05" version="1">MYAGRFILGIGVGIEGGGVGVYISESVPSNKRGSLVSLYQLSIALGEVLGYAIAAIFYEVHGGWRFMVGSSLVFSTIVLIGLFFLPESPRYLVFKGKFGEAFNVFARLRDLGDRHSKIEFVQMVQAAEAERELRLTQNKSKVWFELVTIPRNRRALVYGIVMITLGQLTGINAVMYYLSTLMGRIGFSTKNSVFMSLVGGGSLLIGTIPAILYMDKFGRRVWGYNLVGFFVGLVLVGVGYSIDIETNLAAAEGVYLTGLILYMGFFGSYACLTWVVPAESFSLGTRSQGMTICSALLYLWAFTVTYNFNRMKVAMTYTGLTIGFYGGIAFLGFFYQVLFMPETKGKTLEEIDEIFEKPSRQLIKENLSGLKRFWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLJ8</accession>
    <name>C4YLJ8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mitochondrial escape protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_01716</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the YME2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLJ8"/>
    <dbReference type="PaxDb" id="5476-C4YLJ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01716"/>
    <dbReference type="HOGENOM" id="CLU_007861_1_0_1"/>
    <dbReference type="OMA" id="WTPEQAW"/>
    <dbReference type="OrthoDB" id="10267654at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12433">
        <property type="entry name" value="RRM_Yme2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018850">
        <property type="entry name" value="Mt_escape_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039627">
        <property type="entry name" value="Yme2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034260">
        <property type="entry name" value="Yme2_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198:SF2">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10443">
        <property type="entry name" value="RNA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Mitochondrial escape protein 2 C-terminal" evidence="12">
        <location>
            <begin position="390"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ43479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="867" mass="99345" checksum="0C7B8C8F17F41F74" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLQ3</accession>
    <name>C4YLQ3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_01772</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Common component of the spliceosome and rRNA processing machinery.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLQ3"/>
    <dbReference type="PaxDb" id="5476-C4YLQ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01772"/>
    <dbReference type="HOGENOM" id="CLU_084513_1_1_1"/>
    <dbReference type="OMA" id="EDNYEAR"/>
    <dbReference type="OrthoDB" id="5364946at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000015">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit NHP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="10">
        <location>
            <begin position="44"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ43534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="159" mass="17180" checksum="C5DBB8CEC4F9A64C" modified="2009-07-28" version="1">MGSKKESKSKSSSDDVSTEDNYEKRMSAILPFAKPLASKKLNKKILKTVKKASKAKHVKRGVKEVVKSLRKGEKGLVIIAGDISPADVISHIPVLCEDNSVAYIFIPSKEDLGSAGATKRPTSCVMIVPGGGKSKKNADKTDEYRDGFDDIVKEINASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YML0</accession>
    <name>C4YML0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_02093</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YML0"/>
    <dbReference type="PaxDb" id="5476-C4YML0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02093"/>
    <dbReference type="HOGENOM" id="CLU_034385_1_0_1"/>
    <dbReference type="OMA" id="KNWRYPG"/>
    <dbReference type="OrthoDB" id="2108at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050596">
        <property type="entry name" value="AspAT/PAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383:SF1">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="169"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="560" mass="63525" checksum="03017A42381F363C" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMR4</accession>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
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                <person name="Fitzpatrick D.A."/>
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                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
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                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
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                <person name="Sherlock G."/>
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                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
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                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </evidence>
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    </evidence>
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        </source>
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        </source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
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                <person name="Santos M.C."/>
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                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
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                <person name="Staggs R."/>
                <person name="Stansfield I."/>
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                <person name="Berriman M."/>
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                <person name="Lorenz M.C."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">WO-1</strain>
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    </dbReference>
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    </dbReference>
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        <ligand>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
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                <person name="Stansfield I."/>
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                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN00"/>
    <dbReference type="PaxDb" id="5476-C4YN00"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02238"/>
    <dbReference type="HOGENOM" id="CLU_026936_2_0_1"/>
    <dbReference type="OMA" id="KDYTVMT"/>
    <dbReference type="OrthoDB" id="10261452at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="25"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ43981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="450" mass="51377" checksum="737B27D3B3D5852F" modified="2009-07-28" version="1">MAKRRTKKRTHKKISEEELASIPKSMVLHLGTSLKNHSLTQLVNDFRNVMQPHTAINLRERKSNKLKDFIVMCGPLHVSDIFIFNQTDAGNITLRIGKLPRGPNLQFKINNYSLCKDVRKILKHPKSISKDNSIFQSPPLLVLNGFGKISEMSQHEKLMVTIFQNMFPPIQPQQTKVSSIKRVLLISKNKVTNEIELRHYAINTKLVDENRNVKKLIQSHHNLKKKLPKLTNNQDVSDLLLNPYSIGGLTSDSEIEDDAVVEIQQETFVKKEPTKAITTTITATTEKEVESQSQPQPQPQPQPQQGKSKRAIKLTELGPRLNMSLIKIEEGLIGSSKTIYHSSIQKTEDEIKSLEKKHLLKQQLKLERRSKQQAAVKAKLDKKEAKKARRKAREEGREKDNDDNNNEEEEEEEDSADEEQVDDDDSDSDAVDINPEDYENDSDLYSDVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN44</accession>
    <name>C4YN44_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="13">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_02284</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Oxidizes long-chain alcohols and, in the presence of glutathione, is able to oxidize formaldehyde. Also acts as a S-nitroso-glutathione reductase by catalyzing the NADH-dependent reduction of S-nitrosoglutathione, thereby regulating protein S-nitrosylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-nitrosoglutathione + NADH + H(+) = S-(hydroxysulfenamide)glutathione + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:78371"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:145544"/>
            <dbReference type="ChEBI" id="CHEBI:229723"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="13"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN44"/>
    <dbReference type="SMR" id="C4YN44"/>
    <dbReference type="PaxDb" id="5476-C4YN44"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02284"/>
    <dbReference type="HOGENOM" id="CLU_026673_14_0_1"/>
    <dbReference type="OMA" id="IKGRSEM"/>
    <dbReference type="OrthoDB" id="417550at2759"/>
    <dbReference type="PHI-base" id="PHI:4903"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106322">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106321">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080007">
        <property type="term" value="F:S-nitrosoglutathione reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0520">NAD</keyword>
    <keyword evidence="5 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="14">
        <location>
            <begin position="20"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ44025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="381" mass="40587" checksum="DA9D920D969C2063" modified="2009-07-28" version="1">MSESTVGKPITCKAAVAWEAAKPLVIEDVTVAPPKAHEVRIKVLYSGVCHTDAYTLSGVDPEGAFPVILGHEGAGIVESVGEGVTNVKPGDHVIALYTPECKECKFCKSGKTNLCGKIRATQGKGVMPDGTPRFTCKGKEILHFMGCSTFSQYTVVADISVVAINEKAEFEKACLLGCGITTGYGAATITANVQEGDNVAVFGGGCVGLSVIQGCKERKVNKIILVDINDKKEEWGKQFGATDFVNSTKLPEGTTIVDKLIEMTDGGCDYTFDCTGNVNVMRNALEACHKGWGTSIIIGVAAAGKEISTRPFQLVTGRVWKGAAFGGVKGRSQLPGIVEDYLDGKLKVEEFITHREPLDKINTAFDEMHGGDCIRAVVSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YND0</accession>
    <name>C4YND0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YND0"/>
    <dbReference type="PaxDb" id="5476-C4YND0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01389"/>
    <dbReference type="HOGENOM" id="CLU_026920_0_0_1"/>
    <dbReference type="OMA" id="QHDNQND"/>
    <dbReference type="OrthoDB" id="303107at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="407" mass="47916" checksum="7567AFB6667D24FA" modified="2009-07-28" version="1">MVSRSHSSTPVPIDAGHPIHSLNIGNQDQIASLSKQTPIILLNQQEENGFQTPELVALRNSNKYVFVINWLYNYRGYLKLQSELFDVDLFELELLGFFNAFDLSSLFINKLKLALITSVQNSKHVELEDFEFVFRSHFGSDSPLGGQTDNEQDSVKFDLLNITEKFDILYILINYISKYSKFRDWTEKQGLATRLDPLFKLSSTEYFSLFDDNRLYKRTITYYPLTIPKKRKLSPESPQDYFEEKVFDVKDVKFELIYKNIYEFNEYLTKIKKSSAHKLLYTKLAGKSSAIIDTIFNNEIKKRKYLINKRKEIQMVNLLAVRKRSSRLEAKKQRQEELDRQREEESKYAAERRFERRMKLKNTENIDTGKLSRDQRMKLRQLNNESTPETETNPTSEPEQPEVIVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YND2</accession>
    <name>C4YND2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">chitin deacetylase</fullName>
            <ecNumber evidence="10">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_01391</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Hydrolyzes the N-acetamido groups of N-acetyl-D-glucosamine residues in chitin to form chitosan and acetate. Chitosan is a component of the spore wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Prospore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polysaccharide deacetylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="10"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YND2"/>
    <dbReference type="PaxDb" id="5476-C4YND2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01391"/>
    <dbReference type="HOGENOM" id="CLU_030200_1_0_1"/>
    <dbReference type="OMA" id="QWSIWAM"/>
    <dbReference type="OrthoDB" id="2125469at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030476">
        <property type="term" value="P:ascospore wall assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.370:FF:000008">
        <property type="entry name" value="Chitin deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF133">
        <property type="entry name" value="CHITIN DEACETYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="3" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="9" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946661" description="chitin deacetylase" evidence="15">
        <location>
            <begin position="19"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="16">
        <location>
            <begin position="162"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ43165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="366" mass="41204" checksum="A761EA3A2569CED1" modified="2009-07-28" version="1">MITWLVFYLMLTIPMINGSDLSLRLQSKFMPTSFSPRNIFDTHGPATINSNKEDSSSSSGGGGGSGLPPSPMQFPPKLPFPKWLSDFTGLHEWPDLDPPYIPLDFIDFNKIVNIPIHKQGQCHDTGSNNNNNLTPLSILRTPKACSFDCFNCVEIDDVYTCPKLSQTFDDGPSTATLKLLQSFNQTGLKTTLFTLGVNIVRFPEIYQQSHSMGHIMGSHTWSHKFLPSLTNQEIISQIEWSIWAMNATSNHLPKWFRPPYGGIDNRIRSILRQFGMQAVLWDFDTFDWKMLGGGGGTSNIRKEEDVFSEVEKFKLTKNNKGLILHHDAIQKTVDVGIMIHEKLLNHDQLTVPLCVGGIDYIKTFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNN4</accession>
    <name>C4YNN4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_01498</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNN4"/>
    <dbReference type="PaxDb" id="5476-C4YNN4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01498"/>
    <dbReference type="HOGENOM" id="CLU_016739_0_0_1"/>
    <dbReference type="OMA" id="NCDYAAN"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00779">
        <property type="entry name" value="ProRS_core_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050062">
        <property type="entry name" value="Pro-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033730">
        <property type="entry name" value="ProRS_core_prok"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753:SF2">
        <property type="entry name" value="PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="56"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ43267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="575" mass="66211" checksum="97CDC78571E862BA" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNQ1</accession>
    <name>C4YNQ1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynein heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNQ1"/>
    <dbReference type="PaxDb" id="5476-C4YNQ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02833"/>
    <dbReference type="HOGENOM" id="CLU_526740_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000043">
        <property type="entry name" value="Dynein heavy chain, cytosolic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004602">
        <property type="entry name" value="Dynein heavy chain, cytosolic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF36">
        <property type="entry name" value="DYNEIN HEAVY CHAIN, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="1">
        <location>
            <begin position="217"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="2">
        <location>
            <begin position="349"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="59532" checksum="E127FD2D8FE572CF" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNU4</accession>
    <name>C4YNU4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNU4"/>
    <dbReference type="PaxDb" id="5476-C4YNU4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02877"/>
    <dbReference type="HOGENOM" id="CLU_2133157_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="113" mass="12530" checksum="7EF41D0A8DF271A6" modified="2010-10-05" version="1">MEHLKDNVARTKLFLWKKAKTPEKVVTPREQTQSYTVQDSTPVTITGHREAPTTPRAANTTARKTMTTDVSEMDTSKHTISSNDEASPRKKTNSTGQPRSPIKDPGLNLSPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNV6</accession>
    <name>C4YNV6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">SAGA-associated factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SGF11</name>
        <name evidence="14" type="ORF">CAWG_02889</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). Involved in transcriptional regulation of a subset of SAGA-regulated genes. Within the SAGA complex, participates in a subcomplex, that specifically deubiquitinates histones H2B.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">Component of the 1.8 MDa SAGA transcription coactivator-HAT complex. SAGA is built of 5 distinct domains with specialized functions. Within the SAGA complex, SUS1, SGF11, SGF73 and UBP8 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with SGF73, SUS1 and UBP8.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The C-terminal SGF11-type zinc-finger domain together with the C-terminal catalytic domain of UBP8 forms the 'catalytic lobe' of the SAGA deubiquitination module.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the SGF11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNV6"/>
    <dbReference type="SMR" id="C4YNV6"/>
    <dbReference type="PaxDb" id="5476-C4YNV6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02889"/>
    <dbReference type="HOGENOM" id="CLU_130538_0_0_1"/>
    <dbReference type="OMA" id="RYFSCEN"/>
    <dbReference type="OrthoDB" id="21557at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071819">
        <property type="term" value="C:DUBm complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03047">
        <property type="entry name" value="Sgf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013246">
        <property type="entry name" value="SAGA_su_Sgf11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08209">
        <property type="entry name" value="Sgf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0010">Activator</keyword>
    <keyword evidence="5 10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944358" description="SAGA-associated factor 11" evidence="13">
        <location>
            <begin position="19"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="SGF11-type" evidence="10">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="49"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU261113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ44615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="126" mass="14120" checksum="20DA4CB84BD1C195" modified="2009-07-28" version="1">MLFCFILTKICFFFFSKADSIFNDLINNIIKQHTLTSLTNIKDHSSLLNSSNSNTNSNTNGTIASNGGNGTTSDENNEIENSTIQDKSKLKQLETSRYFRCLNCGRNIAGGRFASHISKCLERKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNZ6</accession>
    <name>C4YNZ6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Agglutinin-like protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAWG_02930</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ALS family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="C4YNZ6"/>
    <dbReference type="PaxDb" id="5476-C4YNZ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02930"/>
    <dbReference type="HOGENOM" id="CLU_257941_0_0_1"/>
    <dbReference type="OMA" id="ASSNCQF"/>
    <dbReference type="OrthoDB" id="3981162at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030446">
        <property type="term" value="C:hyphal cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030445">
        <property type="term" value="C:yeast-form cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043710">
        <property type="term" value="P:cell adhesion involved in multi-species biofilm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043709">
        <property type="term" value="P:cell adhesion involved in single-species biofilm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1280:FF:000001">
        <property type="entry name" value="Agglutinin-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2430">
        <property type="entry name" value="Agglutinin-like protein, N-terminal domain, N2 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008440">
        <property type="entry name" value="Agglutinin-like_ALS_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024672">
        <property type="entry name" value="Agglutinin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043063">
        <property type="entry name" value="Agglutinin-like_N_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033504">
        <property type="entry name" value="ALS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011252">
        <property type="entry name" value="Fibrogen-bd_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793:SF2">
        <property type="entry name" value="AGGLUTININ-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793">
        <property type="entry name" value="ALPHA-AGGLUTININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05792">
        <property type="entry name" value="Candida_ALS"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11766">
        <property type="entry name" value="Candida_ALS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01056">
        <property type="entry name" value="Candida_ALS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="Bacterial adhesins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 17" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946789" description="Agglutinin-like protein N-terminal domain-containing protein" evidence="17">
        <location>
            <begin position="19"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="domain" description="Agglutinin-like protein N-terminal" evidence="18">
        <location>
            <begin position="54"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="583"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="758"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="804"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="874"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="928"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="996"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1081"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1158"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="758"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="805"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="875"/>
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            <dbReference type="Proteomes" id="UP000001429"/>
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    </evidence>
    <sequence length="1366" mass="142767" checksum="FC6F3A3A1D9E91C6" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPD5</accession>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
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        </location>
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    </evidence>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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                <person name="Brunke S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
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    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="OHCU_decarboxylase"/>
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        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37987">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR37987:SF1">
        <property type="entry name" value="OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF09349">
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        <property type="entry name" value="UraD-Like"/>
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            <begin position="11"/>
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    </feature>
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            <dbReference type="Pfam" id="PF09349"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="186" mass="21776" checksum="7DE5D68AEF4F9422" modified="2010-10-05" version="1">MALPTIESFKRLSSKDKRQVLDHLFEPCNTLSNFIFIKVLHQQYNTYPEFINLVRKELLEFLKQSETFQSQYQGEINPVINEIISAHPRLGEPKKETLSVHSNNEQKTLNNDPEIIKKLKELNAAYEKTFPGLRYVVFVNGRSRHEIMDNMQKRIERNDINLERVEAFNAMCDIALDRANKLGIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ15</accession>
    <name>C4YQ15_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="14">RING-box protein HRT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_02569</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RING-box family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ15"/>
    <dbReference type="SMR" id="C4YQ15"/>
    <dbReference type="PaxDb" id="5476-C4YQ15"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02569"/>
    <dbReference type="HOGENOM" id="CLU_115512_2_1_1"/>
    <dbReference type="OMA" id="NACPLDN"/>
    <dbReference type="OrthoDB" id="8962942at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031463">
        <property type="term" value="C:Cul3-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16485">
        <property type="entry name" value="mRING-H2-C3H2C2D_RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000273">
        <property type="entry name" value="E3 ubiquitin-protein ligase RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="56"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ44304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="123" mass="14226" checksum="1FA3AB7C52245A0E" modified="2009-07-28" version="1">MADDQDRMDVDEVESKEPTTEPTTEPTSKPSSKPRFEVKKWTAVAFWSWDMQIENCAICRNHLMEPCIECQPNAMGNIPSEECIPAWGVCNHAFHLHCIRRWLKTRNACPLDSTNWTYQKLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQE8</accession>
    <name>C4YQE8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar protein sorting 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQE8"/>
    <dbReference type="PaxDb" id="5476-C4YQE8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02705"/>
    <dbReference type="HOGENOM" id="CLU_031077_2_0_1"/>
    <dbReference type="OMA" id="FKWKFSS"/>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000010">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="347" mass="39418" checksum="7D22E4CDE3E8EE38" modified="2009-07-28" version="1">MSIFFKAPLDIEIRLDNEDTRKHVEVKTPQGRVEKLPIYKDGESVKGVVTLRTKEGRKLEHLGVRVQLLGSIETNTDGISSSEFLTLATELAAPAQLSHPESYPFEFKNVEKQYESYRGKNVRLRYYIKVTVLRKSSSEIIREKELWVYHYTTAVPKPVTGVSSSSTADSKLGAKKANEDTLQKPATPSSNDDASANTSKGSTISKRNESHSVKMDVGIENCLHIEFEYSRSRFSLKDAIIGKIYFLLVRLKIKHMELSLIRRETVGAPPNQVTDSETVVRFEIMDGAPVKGETIPIRLFLSGFDLVPTYRDVNKKFSTRTYLSLVLIDEDARRYFKQSEIILYRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQH2</accession>
    <name>C4YQH2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Allantoate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_02730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQH2"/>
    <dbReference type="PaxDb" id="5476-C4YQH2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02730"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OMA" id="RKIDMYM"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000245">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF1">
        <property type="entry name" value="ALLANTOATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ44461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="59393" checksum="FF53570F53A06447" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQY1</accession>
    <name>C4YQY1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">IMS import disulfide relay-system CHCH-CHCH-like Cx9C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQY1"/>
    <dbReference type="SMR" id="C4YQY1"/>
    <dbReference type="PaxDb" id="5476-C4YQY1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04478"/>
    <dbReference type="HOGENOM" id="CLU_160816_0_0_1"/>
    <dbReference type="OMA" id="LAFHQCM"/>
    <dbReference type="OrthoDB" id="276296at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052848">
        <property type="entry name" value="CHCH_domain-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031731">
        <property type="entry name" value="CX9C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016611">
        <property type="entry name" value="Mix14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47106">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47106:SF1">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16860">
        <property type="entry name" value="CX9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013232">
        <property type="entry name" value="UCP013232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMS import disulfide relay-system CHCH-CHCH-like Cx9C" evidence="1">
        <location>
            <begin position="14"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="105" mass="12076" checksum="2B750C420E6EA9BC" modified="2010-10-05" version="1">MDQTKPGFLDQFLLEDISRHCPHQFLSFHQCMTLPQPDPNQCFQQQVDLTKCIKTSVPSFAKIQNECFGKMQAYEACLKMNKSNTKSCSHELQNLRNCAFGTIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR97</accession>
    <name>C4YR97_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ribosome biogenesis ATPase RIX7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_04596</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR97"/>
    <dbReference type="PaxDb" id="5476-C4YR97"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04596"/>
    <dbReference type="HOGENOM" id="CLU_000688_8_2_1"/>
    <dbReference type="OMA" id="GLWSTHR"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19518">
        <property type="entry name" value="RecA-like_NVL_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19530">
        <property type="entry name" value="RecA-like_NVL_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000018">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000110">
        <property type="entry name" value="Ribosome biogenesis ATPase RIX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000156">
        <property type="entry name" value="Ribosome biogenesis ATPase RIX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000365">
        <property type="entry name" value="Ribosome biogenesis ATPase RIX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="226"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="555"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="139"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ46251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="827" mass="91952" checksum="2647469055AF25D2" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRF8</accession>
    <name>C4YRF8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_04657</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRF8"/>
    <dbReference type="PaxDb" id="5476-C4YRF8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04657"/>
    <dbReference type="HOGENOM" id="CLU_555744_0_0_1"/>
    <dbReference type="OMA" id="FPYHPLK"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF189">
        <property type="entry name" value="CYTOCHROME C MITOCHONDRIAL IMPORT FACTOR CYC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="171"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ46311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="552" mass="64072" checksum="53C74E5F91C28754" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRI9</accession>
    <name>C4YRI9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_04689</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRI9"/>
    <dbReference type="PaxDb" id="5476-C4YRI9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04689"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="OMA" id="LYAFWIN"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF315">
        <property type="entry name" value="TRANSPORTER MCH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="532"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="188"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="622"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ46342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="673" mass="75154" checksum="E8F1CBFCE43DCFBC" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRN8</accession>
    <name>C4YRN8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_04740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRN8"/>
    <dbReference type="SMR" id="C4YRN8"/>
    <dbReference type="PaxDb" id="5476-C4YRN8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04740"/>
    <dbReference type="HOGENOM" id="CLU_007695_1_0_1"/>
    <dbReference type="OMA" id="YHFAVII"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="641"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ46391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="787" mass="89732" checksum="7451575755F68D6C" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRV8</accession>
    <name>C4YRV8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="10">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_04815</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="10"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRV8"/>
    <dbReference type="MEROPS" id="C12.009"/>
    <dbReference type="PaxDb" id="5476-C4YRV8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04815"/>
    <dbReference type="HOGENOM" id="CLU_018316_1_0_1"/>
    <dbReference type="OMA" id="YIQYEIQ"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017390">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041507">
        <property type="entry name" value="UCH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18031">
        <property type="entry name" value="UCH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038120">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 9 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="11">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7 9">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7 9">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="8 9">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ46461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="300" mass="34326" checksum="B5BC914A720E2216" modified="2009-07-28" version="1" fragment="single">GVFTELVEKLGVENIEINDLYSIDSDTLRTLQPIHGLIFLFKYSKLDREFATSNQPITGEYEGNYLDKDIFFAHQTIQNACATQAVLNILFNLQDVSLGEELNNFKSFVTGFDSEMIGETISNSDLIRSIHNSFSAPHSFVDEDKPPPPPDRDDKDDGLFHFVGYIFKQGKIYELDGLKQYPISHGECSGQDEFIQKLPAIVQERISKYGNELRFSLLAVTNNKLEQAQAMGDQEEIASQLHKRELWKKENELRKHDYTGLIVQLLKNISKEKSDKEWEGFLQKGRNKTQQLIAQSIKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRZ5</accession>
    <name>C4YRZ5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proline-rich protein HUA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRZ5"/>
    <dbReference type="PaxDb" id="5476-C4YRZ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04853"/>
    <dbReference type="HOGENOM" id="CLU_078573_0_0_1"/>
    <dbReference type="OMA" id="GMVHFLF"/>
    <dbReference type="OrthoDB" id="2405700at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038910">
        <property type="entry name" value="Hua1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28031">
        <property type="entry name" value="PROLINE-RICH PROTEIN HUA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28031:SF1">
        <property type="entry name" value="PROLINE-RICH PROTEIN HUA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="29222" checksum="824407717180C149" modified="2009-07-28" version="1">MTNNKDFDLPPSYDEAVHSSSSSNSNRPNHSSQPPAPPARPQTNRPPPPPPPSHPPTSSSSSSNANLYTNNLNLPFTYKRGYYCSKCKNSGYKKNGDICHKCWQTLYLNQNAYNPNQKNLPFTYPKGYYCSKCRNTGYKLKNGKSCQNCWESFGPRNSYSFVSTNYQPSYFGNTTFVPMGGGPPVPNAKRVAPGSPELGGILCGNCRGQGMVHFLFDTELCPVCGGLGRVFTAPPPPLPQHPPMPQTPYMPQYQPQYTNYGSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS38</accession>
    <name>C4YS38_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Riboflavin synthase</fullName>
            <ecNumber evidence="5">2.5.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_04896</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) = 5-amino-6-(D-ribitylamino)uracil + riboflavin</text>
            <dbReference type="Rhea" id="RHEA:20772"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="EC" id="2.5.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.9" evidence="5"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS38"/>
    <dbReference type="SMR" id="C4YS38"/>
    <dbReference type="PaxDb" id="5476-C4YS38"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04896"/>
    <dbReference type="HOGENOM" id="CLU_034388_1_1_1"/>
    <dbReference type="OMA" id="HFVTGHV"/>
    <dbReference type="OrthoDB" id="10258924at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000004">
        <property type="entry name" value="Riboflavin synthase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000006">
        <property type="entry name" value="Riboflavin synthase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006767">
        <property type="entry name" value="PRK09289.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098:SF0">
        <property type="entry name" value="RIBOFLAVIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="RIBOFLAVIN SYNTHASE ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="Lumazine-binding" evidence="10">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="11">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="10">
        <location>
            <begin position="106"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="11">
        <location>
            <begin position="106"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ46541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="237" mass="25753" checksum="108F9DF70CF30CCE" modified="2009-07-28" version="1">MFTGLVETIGTVLDYSKHDDSSTGGDGVSITIGNCSEILEDVKLGDSISTNGVCLTVTEFNLGKTLFKVGVAPETLRRTNLGDLKHGAPVNLERAVTSEVRLGGHIVQGHVDTIAKIVDKKPDGNAIAYTFELRDKEFINYIVHKGFIAIDGASLTVTNVDPSKVQFSIMLISYSQEKVILAKKEVGDTVNIEVDLTGKFIEKQVEINLTGQIENSDSPLNKLISSLVEKKVKEYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS66</accession>
    <name>C4YS66_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable electron transfer flavoprotein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_04925</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 10">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS66"/>
    <dbReference type="PaxDb" id="5476-C4YS66"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04925"/>
    <dbReference type="HOGENOM" id="CLU_034178_0_0_1"/>
    <dbReference type="OMA" id="WRPYAEQ"/>
    <dbReference type="OrthoDB" id="1715808at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000041">
        <property type="entry name" value="Electron transfer flavoprotein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000001">
        <property type="entry name" value="Electron transfer flavoprotein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 9 10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="11">
        <location>
            <begin position="19"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="247"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="261"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="278"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000089-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ46569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="329" mass="34358" checksum="2CFF0DB2A18671ED" modified="2010-10-05" version="1">MASYIAKRLFSRTTVRLDTLALVEGVSNGISPASLSTITAATQIGEPVTAIVFGSNGDSVAEAVAKTEGVSKVLVAKDSEYDHYLAEKVSPLLKKIIEDQKFTHFLTAGSSIGKSILPRLGALLDVQPVSEIVKVVDPTTFVRPIYAGNALATVKSKDSIILASVRASAFPPAEIGGATAPVEQVTESVEFGNSAQFVSEQIVKSERPELGSATRVVSGGRGLKNKEMFDQLIDPLATKLNAAIGASRAAVDSGFCDNSLQVGQTGKIVAPDLYIAVGISGAIQHLAGMKDSKVIVAINKDADAPIFNVADVGLVGDLNEVIPELTNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS71</accession>
    <name>C4YS71_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Ile)-lysidine synthetase</fullName>
            <ecNumber evidence="1">6.3.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_04930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(34) in tRNA(Ile2) + L-lysine + ATP = lysidine(34) in tRNA(Ile2) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="1"/>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS71"/>
    <dbReference type="PaxDb" id="5476-C4YS71"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04930"/>
    <dbReference type="HOGENOM" id="CLU_015599_1_0_1"/>
    <dbReference type="OMA" id="MCLTHLL"/>
    <dbReference type="OrthoDB" id="434144at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032267">
        <property type="term" value="F:tRNA(Ile)-lysidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="TRNA(ILE)-LYSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033:SF1">
        <property type="entry name" value="TRNA(ILE)-LYSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="7">
        <location>
            <begin position="23"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ46574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="483" mass="55866" checksum="15790BC7165C12BF" modified="2009-07-28" version="1">MAITNVLFRKSLDRLFNGNAPKKVAVALSGGPDSMLLTWLLSQCKFEIYAITIDHKYRPEASREALSVYERVKNWNLNHIIKSLDYPAGVDPTKLNNFEEIAREKRYEAMAQVCYDKDIPVLFLGHHRDDQLETFIQRLQGNSSIFGLAGTHKVSPLPISKDLSPTSTFFNQANQVRILRPFWDYDKQDILETCQLNNIAYVTDPTNKDVSLTRRNYLRHLINDIIPAKNNQSHSPYLLIDKSQLIDSHTKCLEFATMFENRAMALSESLQSSGLIKEFPALGSLQVKFPRQCLDQTNGIVTSRFLYRILHPYSTLKHYHWAYAKLERQLIPRITKFLEQGQSGTFKLTMMNLVFEVTNNIQSEYVPIHIYRCPITTKDWSSMQETLTVSPEWSEWKLFDSRFWLRARSNSYSGQLSVIPYIHKKHKQLLHDNLDANKSFDTLPAIKANSGKIIAFPTLGAMCSDYGIVYEWRPKKNRFSYCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS97</accession>
    <name>C4YS97_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Iron-sulfur clusters transporter ATM1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Iron-sulfur clusters transporter atm1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CAWG_04958</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins. Hydrolyzes ATP. Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS97"/>
    <dbReference type="PaxDb" id="5476-C4YS97"/>
    <dbReference type="HOGENOM" id="CLU_000604_84_1_1"/>
    <dbReference type="OMA" id="VFHIIPI"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140466">
        <property type="term" value="P:iron-sulfur cluster export from the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18582">
        <property type="entry name" value="ABC_6TM_ATM1_ABCB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000004">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000287">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF402">
        <property type="entry name" value="IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="21">
        <location>
            <begin position="52"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="20">
        <location>
            <begin position="382"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="634"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EEQ46600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="666" mass="74787" checksum="2C59EC53A1FA25A5" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-10-19" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSF6</accession>
    <accession>P28872</accession>
    <accession>Q5A8N4</accession>
    <name>CARP1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>Candidapepsin-1</fullName>
            <ecNumber>3.4.23.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>ACP 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Aspartate protease 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Secreted aspartic protease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SAP1</name>
        <name type="synonym">PRA10</name>
        <name type="synonym">PRA3</name>
        <name type="ORF">CAWG_05021</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="J. Bacteriol." volume="176" first="1702" last="1710">
            <title>A fourth secreted aspartyl proteinase gene (SAP4) and a CARE2 repetitive element are located upstream of the SAP1 gene in Candida albicans.</title>
            <authorList>
                <person name="Miyasaki S.H."/>
                <person name="White T.C."/>
                <person name="Agabian N."/>
            </authorList>
            <dbReference type="PubMed" id="7907585"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1993" name="J. Bacteriol." volume="175" first="6126" last="6133">
            <title>Three distinct secreted aspartyl proteinases in Candida albicans.</title>
            <authorList>
                <person name="White T.C."/>
                <person name="Miyasaki S.H."/>
                <person name="Agabian N."/>
            </authorList>
            <dbReference type="PubMed" id="8407785"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 51-65</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1995" name="J. Bacteriol." volume="177" first="2953" last="2955">
            <title>The 'universal' leucine codon CTG in the secreted aspartyl proteinase 1 (SAP1) gene of Candida albicans encodes a serine in vivo.</title>
            <authorList>
                <person name="White T.C."/>
                <person name="Andrews L.E."/>
                <person name="Maltby D."/>
                <person name="Agabian N."/>
            </authorList>
            <dbReference type="PubMed" id="7751316"/>
        </citation>
        <scope>PARTIAL PROTEIN SEQUENCE</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 of insulin B chain. Activates trypsinogen, and degrades keratin.</text>
            <dbReference type="EC" id="3.4.23.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">O-glycosylated.</text>
    </comment>
    <comment type="miscellaneous">
        <text>Expressed exclusively in O (opaque) cells and not in W (white) cells of strain WO-1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.24"/>
    <dbReference type="EMBL" id="L12451">
        <property type="protein sequence ID" value="AAA34370.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="L12452">
        <property type="protein sequence ID" value="AAA34371.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSF6"/>
    <dbReference type="SMR" id="C4YSF6"/>
    <dbReference type="MEROPS" id="A01.014"/>
    <dbReference type="GlyCosmos" id="C4YSF6">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YSF6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05021"/>
    <dbReference type="HOGENOM" id="CLU_013253_9_1_1"/>
    <dbReference type="OMA" id="GIGYKTN"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000011">
        <property type="entry name" value="Aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000023">
        <property type="entry name" value="Aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0064">Aspartyl protease</keyword>
    <keyword id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000413046" description="Activation peptide" evidence="5">
        <location>
            <begin position="19"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000413047" description="Candidapepsin-1">
        <location>
            <begin position="51"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="64"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="305"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele 2.6.">
        <original>Y</original>
        <variation>N</variation>
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele 2.4.">
        <original>V</original>
        <variation>A</variation>
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="8407785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="391" mass="41630" checksum="2A076AB9FEF60F3D" modified="2009-07-28" version="1" precursor="true">MFLKNIFIALAIALLVDASPAKRSPGFVTLDFDVIKTPVNATGQEGKVKRQALPVTLNNEHVSYAADITIGSNKQKFNVIVDTGSSDLWVPDASVTCDKPRPGQSADFCKGKGIYTPKSSTTSQNLGTPFYIGYGDGSSSQGTLYKDTVGFGGASITKQVFADITKTSIPQGILGIGYKTNEAAGDYDNVPVTLKNQGVIAKNAYSLYLNSPNAATGQIIFGGVDKAKYSGSLIAVPVTSDRELRITLNSLKAVGKNINGNIDVLLDSGTTITYLQQDVAQDIIDAFQAELKSDGQGHTFYVTDCQTSGTVDFNFDNNVKISVPASEFTAPLSYANGQPYPKCQLLLGISDANILGDNFLRSAYLVYDLDDDKISLAQVKYTSASNIAALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSG3</accession>
    <name>C4YSG3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSG3"/>
    <dbReference type="PaxDb" id="5476-C4YSG3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05029"/>
    <dbReference type="HOGENOM" id="CLU_049915_1_0_1"/>
    <dbReference type="OMA" id="FARDPPD"/>
    <dbReference type="OrthoDB" id="10267950at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008796">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004780">
        <property type="term" value="F:sulfate adenylyltransferase (ADP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053364">
        <property type="entry name" value="Fork-head_TF_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42746">
        <property type="entry name" value="DIADENOSINE 5',5'''-P1,P4-TETRAPHOSPHATE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42746:SF2">
        <property type="entry name" value="DIADENOSINE 5',5'''-P1,P4-TETRAPHOSPHATE PHOSPHORYLASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="2">
        <location>
            <begin position="51"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="1">
        <location>
            <begin position="237"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="366" mass="41978" checksum="C6E653F3DE001379" modified="2009-07-28" version="1">MASKYQLSDDFYLKLSNKYDSAIKGEHILFNGDSAINEIEKIAITDENDNQSNTTATTTTTTTTIDVQSTLLKSLMHRPEIGTKPKIESSQNSNPFLKPEPELTIVDNYNDDEFKIVFNKFPVVPRHFMLITKEFKSQNTPLSPSELMATYKILQALKNQNQNQNQNQNSDQNTENWFAFYNCGPESGASQPHKHIQFMTLPSREQFKPYAETLFQNKEDDEQQQEPQKIEPKQNKDLPFAHFFIPIVADDVVDEEELPNLFSSILQKTLTELRETEQTHISYNFIMTLNYMLMIPRSKGKYGGDENKDEDEDKDKLGINSCGFQGLILCKNQELFDLVKSVGPLQILKDVGLPNSSHKTTTEYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSH2</accession>
    <name>C4YSH2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Antisense-enhancing sequence 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSH2"/>
    <dbReference type="PaxDb" id="5476-C4YSH2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05038"/>
    <dbReference type="HOGENOM" id="CLU_048756_0_0_1"/>
    <dbReference type="OMA" id="AHWTNLS"/>
    <dbReference type="OrthoDB" id="75169at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774:SF32">
        <property type="entry name" value="ANTISENSE-ENHANCING SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33330" checksum="B8ED409E7C83D2D3" modified="2009-07-28" version="1">MPRFKQVDVFTNVKYLGNPVAVIYDSDNLTTQEMQKIARWTNLSETTFILTPKSSIADYSIRIFTSGGNELPFAGHPTLGTAFALLEDGKIKPNDNGQIIQECGAGLVKISVEKTPNNNNNNSNELPFLLSFQLPYFKFHEIDDKVIEELQHSWNGTNIIGKPVLIDAGPKWAVFQLGSGKEVLDLNVDLAQIERLSLENGWTGIGVFGKHNENGDSVELRNIAPAVGVAEDPACGSGSGAIGAYLANHVFNEKEKFTIDISQGKPIERDAKIQVKVNRLTTKNGDLSIHVGGHAITCFEGTYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSI0</accession>
    <name>C4YSI0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_05046</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSI0"/>
    <dbReference type="PaxDb" id="5476-C4YSI0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05046"/>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="OMA" id="QGQMKEK"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ46683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="343" mass="37748" checksum="86657B300114361B" modified="2009-07-28" version="1">MSTPITVIVSGATGFIAQHVVKQLLAKNYQVIGTVRSTAKGDHLLKLFNNPQNLSYEIVEDVGTKGAFDKVLQQHGEAKVFLHLASPFHFNVTDVEKELLLPAVDGTKNVLQAIYSFGNNIEKVVITSSYAAISTASKEADKNAIITEKDWNKISWQDALLNPVNGYRGSKKFAEKAAWDFIKSNDNVKFSLSTINPSFVFGPQSFGSEIKQSLNTSSEIINSILKLKPNDSIPASKGGWVDVRDVAKAHIIAFENEDAKNQRILLNSGRFTSQSLVDIINDKFPDLKGKIPVGEPGSDKSVIAESLATIDDTKSRELLGFEYYDLEQSVYDTVEQIVNAHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSP3</accession>
    <name>C4YSP3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sec20 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_05111</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSP3"/>
    <dbReference type="PaxDb" id="5476-C4YSP3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05111"/>
    <dbReference type="HOGENOM" id="CLU_051527_0_0_1"/>
    <dbReference type="OMA" id="WSFFKIF"/>
    <dbReference type="OrthoDB" id="46868at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Sec20 C-terminal" evidence="11">
        <location>
            <begin position="148"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ46746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="332" mass="38691" checksum="22D4DFD68E4D4CA1" modified="2009-07-28" version="1">MSTVYYKKLDKLQFQIYDLFSSLLQLSETEDESVYKASFDDTVQEIDSLLIAFKDLLRLLRPKDKSNKFDTYELKFHSLKHKLRELQVFINDQQQDKLHEYRIKHFHLQDSPVDTINNEFARDQLFADRSTKKTKKETEASINQQIVSQNKQITKSLQASRQLLSAGILQSELNIDNIDQQTKDLYKLNEGFIQFNDLLNRSKKIVKFIEKQDKADRQRIYLSMGFFILCCSWVVYRRILRRPLKIFLWSFFKIFNIFNWLLGGGRSKGLSASDMIVSSVIAATTEIVDYEATKALLDTLSHAVDSNTAIDTLAMVVESFTTSSMERIVDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSS5</accession>
    <name>C4YSS5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CP-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_05144</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in the mitochondrial lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSS5"/>
    <dbReference type="PaxDb" id="5476-C4YSS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05144"/>
    <dbReference type="HOGENOM" id="CLU_011072_2_0_1"/>
    <dbReference type="OMA" id="VNKADMM"/>
    <dbReference type="OrthoDB" id="61815at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001151">
        <property type="entry name" value="Large subunit GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="8">
        <location>
            <begin position="191"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="592"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="649"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="598"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="665"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ46778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="685" mass="77991" checksum="0F578B1DA46DFFD3" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSU1</accession>
    <name>C4YSU1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSU1"/>
    <dbReference type="PaxDb" id="5476-C4YSU1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05160"/>
    <dbReference type="HOGENOM" id="CLU_2277143_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="102" mass="11903" checksum="0F34AA2B082FAF99" modified="2009-07-28" version="1">MSKVDRIQNLFHSVIIHALMISDLLIIRLFTQTSIISLFRQNSHASSNNYHFLFLSLFLLPKKHLILFLLVSNPIMLFSLSHYKNFSSHSLMICSITSSRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSZ1</accession>
    <name>C4YSZ1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Argininosuccinate lyase</fullName>
            <ecNumber evidence="4">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_05688</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="4"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSZ1"/>
    <dbReference type="PaxDb" id="5476-C4YSZ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05688"/>
    <dbReference type="HOGENOM" id="CLU_027272_2_1_1"/>
    <dbReference type="OMA" id="DFAIEFC"/>
    <dbReference type="OrthoDB" id="2561043at2759"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000001">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="7">
        <location>
            <begin position="17"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="8">
        <location>
            <begin position="375"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ47127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="468" mass="52793" checksum="D17136267DBF3222" modified="2009-07-28" version="1">MSQQQDKQPSENKLWGGRFTGATDPLMDLYNASLPYDKVMYDADLTGTKVYTQGLNKLGLITTEELNLIHQGLEQIRQEWHDNKFIIKAGDEDIHTANERRLGEIIGKNISGKVHTGRSRNDQVATDMRIFVRESLLNLSKILHQFITAILERAHKEIDVLMPGYTHLQKAQPIRWAHWLSSYATYFTEDYKRLQEIITRVNQSPLGSGALAGHPYGIDREFLAKGLGFDGVIGNSLTAVSDRDFVVESLFWSTLFMNHISRFSEDLIIYSSGEFGFIKLADAYSTGSSLMPQKKNPDSLELLRGKSGRVFGQLSGFLMSIKSIPSTYNKDMQEDKEPLFDALTTVEHSILIATGVISTLSIDKQNMEKALTMDMLATDLADYLVRKGVPFRETHHISGECVRKAEEEKLSGIDQLSFEQFQQIDSRFEKDVMETFDFEASVERRDAIGGTAKSAVLKQLENLKSILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTC1</accession>
    <name>C4YTC1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTC1"/>
    <dbReference type="PaxDb" id="5476-C4YTC1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05407"/>
    <dbReference type="HOGENOM" id="CLU_1686328_0_0_1"/>
    <dbReference type="OrthoDB" id="10449711at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="156" mass="16764" checksum="FB8DE9F91224258F" modified="2009-07-28" version="1">MFSLTIIVPFSINAERHLLQNSTNTSSGNCPTHHWHQINQYECSGCQSCIPISYIFPNLPLFFTSVNSLCICATKGLTGSNKSTESSTFQSKSRVILPMPAPISIVVLGTPSGHVISVASLRKNVEDPTMSALGTEVCSPYPPSTPSTDAGVLDQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTG8</accession>
    <name>C4YTG8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial 37S ribosomal protein MRPS16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_05460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTG8"/>
    <dbReference type="PaxDb" id="5476-C4YTG8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05460"/>
    <dbReference type="HOGENOM" id="CLU_100590_2_2_1"/>
    <dbReference type="OMA" id="RSKYWLG"/>
    <dbReference type="OrthoDB" id="407221at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1320.10:FF:000013">
        <property type="entry name" value="Mitochondrial ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_bS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_bS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020592">
        <property type="entry name" value="Ribosomal_bS16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_bS16_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919:SF20">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="Ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00732">
        <property type="entry name" value="RIBOSOMAL_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ46909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="16376" checksum="BA477480D39D0A8C" modified="2009-07-28" version="1">MSSPIMSVAEKTAYKRNMVKIRLARFGRKHQPIYNIVVMKAKKAQQKLPMEVIGTYNPIPVPSSGNDLGLKIKDVSLDLHRTKYWLGMGAVPTPRVTWLLKKVGLLPQFWPKTSALSQHIDKPVVEEIRETQELPVDYVRKRD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTH8</accession>
    <name>MDM12_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial distribution and morphology protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Mitochondrial inheritance component MDM12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MDM12</name>
        <name type="ORF">CAWG_05471</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="1">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTH8"/>
    <dbReference type="SMR" id="C4YTH8"/>
    <dbReference type="PaxDb" id="5476-C4YTH8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05471"/>
    <dbReference type="HOGENOM" id="CLU_026794_2_0_1"/>
    <dbReference type="OMA" id="KRAHFCF"/>
    <dbReference type="OrthoDB" id="3356905at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Mdm12"/>
    </dbReference>
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        <property type="entry name" value="SMP_LBD"/>
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    <dbReference type="PANTHER" id="PTHR28204">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0445">Lipid transport</keyword>
    <keyword id="KW-0446">Lipid-binding</keyword>
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    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
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        <location>
            <begin position="1"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
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        </location>
    </feature>
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            <begin position="81"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
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            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="427" mass="47943" checksum="6087EB7377A201ED" modified="2009-07-28" version="1">MSFDINWNQLTIDDTINQSIKEFLDQQFKNISLPSFISNLAVTDFNLGEIPPEVTIRHIGDPFEEFYEDENILGAMNEANNDSKDEHLKNHGDGINKDSGYNSQNLDDEDEDDEDDDEDDEDEEEEDEDDYDDHDLGTINEGISLLNFNENSTTPSANSFAGSAAPPLPPPLNPSRDSFHSILHPYGVNSIIGATGAGSETPTNILNQNYLSSRVLPKISVKQKQPHHDDNDIQLIVEINYKGDMHINLLVNLLVNYPSPNFISLPIKLHITDIVIHSIATIAYLKKSVFLSFLCDVDDTFPDFDSNVQTPTSTTGGNFVDYYSNDATINKERIDIVKKIKIESEIGEVENNILRNVGKVEKFLVEQLRNILRDEIAWPSWICIDMNDDDDEEEEEESEDNDGGNSDLNDNDGKHGDGRTDETEAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTN4</accession>
    <name>C4YTN4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_05529</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000313">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05529"/>
    <dbReference type="HOGENOM" id="CLU_007231_0_0_1"/>
    <dbReference type="OMA" id="KWGFFVQ"/>
    <dbReference type="OrthoDB" id="8436363at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DRC5"/>
    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107:SF30">
        <property type="entry name" value="GLC7-INTERACTING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107">
        <property type="entry name" value="YNEIN REGULATORY COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="527"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1204"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1314"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="119"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
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        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="232"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
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            <end position="390"/>
        </location>
    </feature>
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        <location>
            <begin position="466"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1210"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1227"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1322"/>
            <end position="1332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ46975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1362" mass="150317" checksum="01DB5BBEDAB1BE10" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-24" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>P0CC07</accession>
    <accession>Q5AI50</accession>
    <name>RS3A_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">40S ribosomal protein S1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">RPS1</name>
        <name type="synonym">PLC1</name>
        <name type="synonym">RP10</name>
        <name type="synonym">RPS10</name>
        <name type="ORF">CAWG_01075</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0CC07"/>
    <dbReference type="SMR" id="P0CC07"/>
    <dbReference type="PaxDb" id="5476-P0CC07"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01075"/>
    <dbReference type="HOGENOM" id="CLU_062507_0_0_1"/>
    <dbReference type="OMA" id="TRFKGHE"/>
    <dbReference type="OrthoDB" id="9834376at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000389562" description="Small ribosomal subunit protein eS1">
        <location>
            <begin position="2"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="modified residue" description="N-acetylalanine; partial" evidence="1">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="256" mass="28987" checksum="D0A5442E27FCA577" modified="2009-11-24" version="1">MAVGKNKRLSKGKKGLKKKVVDPFTRKDWFDIKAPTTFENRNVGKTLINRSTGLKNAADGLKGRVFEVCLADLQGSEDHSYRKIKLRVDEVQGKNLLTNFHGLDFTSDKLRSLVRKWQSLVEANVTVKTSDDYVLRVFAIAFTKRQPNQIKKTTYAQSSKLREVRKKMIEIMQREVSNCTLAQLTSKLIPEVIGREIEKSTQTIFPLQNVHIRKVKLLKQPKFDLGSLLALHGEGSTEEKGKKVSSGFKDVVLESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCM4</accession>
    <name>C4YCM4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_00258</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCM4"/>
    <dbReference type="PaxDb" id="5476-C4YCM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00258"/>
    <dbReference type="HOGENOM" id="CLU_061221_3_1_1"/>
    <dbReference type="OMA" id="QSNFVEY"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000010">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000804">
        <property type="entry name" value="Clathrin_sm-chain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00989">
        <property type="entry name" value="CLAT_ADAPTOR_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="7">
        <location>
            <begin position="3"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ42060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="145" mass="17362" checksum="D2460380BCB80E5C" modified="2009-07-28" version="1">MSIHFILVLNRQGKSRLVKWFDNSYTPQQKQQYISDIHRLISSRDSKHQSNFVEFQQNKLVYRRYAGLYFLCGIDLIDSELSYLESLHFFVEILDVYFDSVCEVDLVFNFYELYYILDEIYLGGEIQELSKKKILNRLSYLDGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCP0</accession>
    <name>C4YCP0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_00274</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCP0"/>
    <dbReference type="PaxDb" id="5476-C4YCP0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00274"/>
    <dbReference type="HOGENOM" id="CLU_719602_0_0_1"/>
    <dbReference type="OMA" id="DTTIYMT"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="315"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ42076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="384" mass="42544" checksum="174A3B279AD310A1" modified="2009-07-28" version="1">MKIADKRDDGDTTIYMTLTSTSTLGSKSSPNASPTNVIQIVSWVAQTIETTIVTSTPVLKVPSTSQVNTVTSKSITTVSNTAETKKVIGSSSADATTSPSQSDSLSPTASKKVGAVSTIPIQNSFSDVSYSTGNRSLQIGLAIGIPIAIFSIFFIVLGIWYYIRERKRKRKTLSFNEKYYKPRESDATLTADKPYPVLFSPGAYFKDERQYELPQKRDRLTSRLSKSFPIRKKEKEISSTVNFAKHMSVLTPIFLKKFNLKKTVEENNETVKPQILSIPENPRENAMKPTDNLNLPPVITIGSSGLDPVRGGISPEQSLYTVIRSYNKSLGDELNIEVGDKAVILEKHSDGWCKIRLVRMGKDYYNHQLSSDIGLVPKMCLQKI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD35</accession>
    <name>AIM21_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>Altered inheritance of mitochondria protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">AIM21</name>
        <name type="ORF">CAWG_00423</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in mitochondrial migration along actin filaments.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
        <text evidence="1">Cortical actin patches.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD35"/>
    <dbReference type="PaxDb" id="5476-C4YD35"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00423"/>
    <dbReference type="HOGENOM" id="CLU_336152_0_0_1"/>
    <dbReference type="OMA" id="FQQMFNQ"/>
    <dbReference type="OrthoDB" id="4096963at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021582">
        <property type="entry name" value="Aim21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11489">
        <property type="entry name" value="Aim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000399515" description="Altered inheritance of mitochondria protein 21">
        <location>
            <begin position="1"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="704"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="799"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="474"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="570"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="634"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="656"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="809"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="847" mass="93145" checksum="23DDF7914824D689" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDL1</accession>
    <name>C4YDL1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_00608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDL1"/>
    <dbReference type="PaxDb" id="5476-C4YDL1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00608"/>
    <dbReference type="HOGENOM" id="CLU_1377945_0_0_1"/>
    <dbReference type="OMA" id="QESDEIM"/>
    <dbReference type="OrthoDB" id="4024846at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018565">
        <property type="entry name" value="Nkp2/Cnl2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09447">
        <property type="entry name" value="Cnl2_NKP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ42397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="167" mass="19147" checksum="23848AB6E082CE18" modified="2009-07-28" version="1">MTTNTSSPDILKEYLIKRSEIRDHVSLDAFKKEFPSNVSIELIEKIYKEIERQQQHRFSKIKQNIESQFDIPISNLISEISTNSGTVKKSILLNLTKELELLMSKLATQESELNENIKQKINDLNSLIPLLPSIQFAEEQESDEIMDDVLQKIDTISGILSLNQSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDL9</accession>
    <name>C4YDL9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Suppressor of toxicity of sporidesmin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_00616</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YDL9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00616"/>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="OMA" id="RTSMRHD"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005285">
        <property type="entry name" value="Drug-R_PDR/CDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00956">
        <property type="entry name" value="3a01205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="551"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="593"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="628"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="659"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="764"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="151"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="846"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ42405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1299" mass="147438" checksum="AFBA101A85015D21" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YE84</accession>
    <name>C4YE84_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptide hydrolase</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_00838</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YE84"/>
    <dbReference type="MEROPS" id="M28.006"/>
    <dbReference type="PaxDb" id="5476-C4YE84"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00838"/>
    <dbReference type="HOGENOM" id="CLU_025866_0_0_1"/>
    <dbReference type="OMA" id="GMLQQDM"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03879">
        <property type="entry name" value="M28_AAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000042">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005125131" description="Peptide hydrolase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="10">
        <location>
            <begin position="198"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ42620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="417" mass="47312" checksum="52FAB6F1F2D64835" modified="2009-07-28" version="1">MRITVILGFTVCLTNAFPLGFPEWTTNAVSFFTNDGYSNSDRLIKLGPENYRIVSENEKLKLKRSKINFIDVTNQIPIESAIEQGLTLKPAPPSLWRKFQLMGSKQITTLKKKIPVYNYPKHPQYEKKVLSIFQSINVEFMQEKLSKFTSFYTRYYKSDYGAESAEWLYQQISDIIAPVKDTVTISKVEHKGWKQFSIIVSIPGKVTDKVVVGAHQDSANLILPNLMKAPGADDDGSGTVTILESLRLLIASYKDGTFKPYNTLEFHWYSAEEGGLLGSIDVFTRYSESNQVVVGMLQQDMTGYTQGSIDQGIEPHFGLIADYTSVELNNFLKQIITNYNSIPYHESECGYACSDHASALENGYPSSFLIESEMKYSNKYIHSTMDTIDRLDWAHIKEHVKLTVAYAYELSLARNLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF12</accession>
    <name>C4YF12_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar membrane-associated protein IML1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Vacuolar membrane-associated protein iml1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_01122</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IML1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YF12"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01122"/>
    <dbReference type="HOGENOM" id="CLU_000935_1_1_1"/>
    <dbReference type="OMA" id="RTWHFKR"/>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04449">
        <property type="entry name" value="DEP_DEPDC5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000707">
        <property type="entry name" value="Vacuolar membrane-associated protein iml1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045838">
        <property type="entry name" value="DEPDC5_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19418">
        <property type="entry name" value="DEPDC5_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="DEP" evidence="8">
        <location>
            <begin position="1077"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="687"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1166"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1175"/>
            <end position="1185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ42898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1385" mass="159806" checksum="A00A43B032AA15EF" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF21</accession>
    <name>C4YF21_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_01132</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF21"/>
    <dbReference type="PaxDb" id="5476-C4YF21"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01132"/>
    <dbReference type="HOGENOM" id="CLU_028610_0_0_1"/>
    <dbReference type="OMA" id="YDQPHEI"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053245">
        <property type="entry name" value="MitoProcess-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563:SF1">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="444"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ42907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="673" mass="77366" checksum="D4FF89834B255DBC" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF84</accession>
    <name>C4YF84_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rho GDP-dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_01196</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF84"/>
    <dbReference type="SMR" id="C4YF84"/>
    <dbReference type="PaxDb" id="5476-C4YF84"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01196"/>
    <dbReference type="HOGENOM" id="CLU_138077_0_0_1"/>
    <dbReference type="OMA" id="IWSYKWT"/>
    <dbReference type="OrthoDB" id="4005750at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.30:FF:000010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ42970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="21298" checksum="B201E1CBA269CB14" modified="2010-10-05" version="1">MSSTLQNSITVAPVGKKTREEVLADFENDLVRFESMSLKLYGHDQPLQFSRDMVPFPQRLHFRLPEYSIYLLTIRFKVKQRPLRNLTYHQTVKKKRIPVDDRNLEMKEEASVNNLDDEDDYHEVTFAPSGVPGGTFLRGKYKARSSVKENGVLIWSYKWTLEVIKKGSTPEIGGFGDEEEEPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFB8</accession>
    <name>C4YFB8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFB8"/>
    <dbReference type="PaxDb" id="5476-C4YFB8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01234"/>
    <dbReference type="HOGENOM" id="CLU_3207564_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="45" mass="4825" checksum="03F5DB278EF39EEF" modified="2009-07-28" version="1">MRLADGKANGQKLFMAGRLKVKGNLLKAVSIESLFKDLGPVPAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFC1</accession>
    <name>C4YFC1_CANAW</name>
    <protein>
        <recommendedName>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
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                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
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</entry>
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        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="271" mass="31762" checksum="D8F297B4D8538744" modified="2009-07-28" version="1">MTTNKDNSNNNDNPDNKEFTRRPNPKGWTPPKAPYNPYDPNDTRPPGGYPSEFKLPGQEPSGFSSLPKSPTQYQKVNETMERLNYTARPQSDLYPGQYKVLRRVDTNKRLDIGNRYFGTFIIGSVIVYGVFFHRWNDGRENVFSDFYRAQLKLKEKLMGGLNEQEYDDLYHPRDSGIVVRNVRDAQYIPEDIRKTSETNYNLNRPGERHVLEAQRIQQEQEEKMLKELDYHKKFAQSVLKEEGIDVKELQNQQEAMIITADKPKKKWFGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG26</accession>
    <name>C4YG26_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor G, mitochondrial</fullName>
            <shortName evidence="9">EF-Gmt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Elongation factor G 1, mitochondrial</fullName>
            <shortName evidence="9">mEF-G 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Elongation factor G1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MEF1</name>
        <name evidence="11" type="ORF">CAWG_00142</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YG26"/>
    <dbReference type="SMR" id="C4YG26"/>
    <dbReference type="PaxDb" id="5476-C4YG26"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00142"/>
    <dbReference type="HOGENOM" id="CLU_002794_4_0_1"/>
    <dbReference type="OMA" id="GQFAKVQ"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04091">
        <property type="entry name" value="mtEFG1_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000003">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000022">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000015">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000558">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047872">
        <property type="entry name" value="EFG_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009381">
        <property type="entry name" value="PRK12740.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636:SF2">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="66"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="75"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="146"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="200"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ41950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="761" mass="84387" checksum="42AC48D9EF5CF12E" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG96</accession>
    <name>C4YG96_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_00217</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YG96"/>
    <dbReference type="PaxDb" id="5476-C4YG96"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00217"/>
    <dbReference type="HOGENOM" id="CLU_009026_1_0_1"/>
    <dbReference type="OMA" id="SAVMVCD"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17781">
        <property type="entry name" value="CBS_pair_MUG70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17782">
        <property type="entry name" value="CBS_pair_MUG70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06409">
        <property type="entry name" value="PB1_MUG70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
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    <sequence length="605" mass="66267" checksum="1F36C896FBECB0A8" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
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                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
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                <person name="Sherlock G."/>
                <person name="Shah P."/>
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                <person name="Lorenz M.C."/>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
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    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </organism>
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                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
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                <person name="Logue M.E."/>
                <person name="Martin R."/>
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                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
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                <person name="Silverstein K.A."/>
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                <person name="Lorenz M.C."/>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
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    </dbReference>
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            <end position="37"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="14"/>
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        </location>
    </feature>
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        <location>
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            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ44834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="208" mass="23962" checksum="E8EA5502681AFD01" modified="2009-07-28" version="1">MMTSDNTSKISNQSISRSPSPVASSINRSNNSTPLSSCERPISLEIYRRVPTPPSPQLSLMSSFNVDFDSVNLDNDFQLQINPTTVPNDIIKESNVVEKVMGFFKKREDVDPKQSNIKPIKKKRSLGCLNFFKRDDANESIHQPTKSILKSKINKNYEAEQSKCKCEELLDFEEFMGRFEYTEQLKNSNDEALSMLRMEQVRNYFYHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGG5</accession>
    <name>C4YGG5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <gene>
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    <organism evidence="4 5">
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        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
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            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
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                <person name="Santos M.C."/>
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                <person name="Sherlock G."/>
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                <person name="Silverstein K.A."/>
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                <person name="Staggs R."/>
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                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGG5"/>
    <dbReference type="PaxDb" id="5476-C4YGG5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03141"/>
    <dbReference type="HOGENOM" id="CLU_141774_1_0_1"/>
    <dbReference type="OMA" id="TLWENNW"/>
    <dbReference type="OrthoDB" id="10370785at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ44847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="93" mass="10747" checksum="1D4EF95811EA6374" modified="2009-07-28" version="1">MSDATKLDSKPSTTIPSKHTSGLTEEEKNVIKTLEEDDEFEDFPEDDSKWSSNSTNKLSEQNLWEEDWDDDDGQDEVSNKLREELKKTIKPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGI3</accession>
    <name>C4YGI3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome maturation factor UMP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_03160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the POMP/UMP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGI3"/>
    <dbReference type="SMR" id="C4YGI3"/>
    <dbReference type="PaxDb" id="5476-C4YGI3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03160"/>
    <dbReference type="HOGENOM" id="CLU_100687_0_1_1"/>
    <dbReference type="OMA" id="MSMRIVP"/>
    <dbReference type="OrthoDB" id="15001at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008012">
        <property type="entry name" value="Ump1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828:SF3">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05348">
        <property type="entry name" value="UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ44865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="16649" checksum="1DC46105D334EE62" modified="2009-07-28" version="1">MSLRVVPSSTNKESSVNTTKFGQPAEHAPALQDSLRSQEGPLNIASKINNRHPLESQVTNWEKTQEENRMETYRRIFGAGAPIKRAMELEIVESSSFRPSLLGGVDSMHKDILLNKDSSVDWEDVYPGGFANGDNVKDFHSEMEKQMGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGP0</accession>
    <name>C4YGP0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGP0"/>
    <dbReference type="PaxDb" id="5476-C4YGP0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03221"/>
    <dbReference type="HOGENOM" id="CLU_070609_0_0_1"/>
    <dbReference type="OMA" id="WTWEKLV"/>
    <dbReference type="OrthoDB" id="2100128at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398:SF1">
        <property type="entry name" value="CSN8_PSMD8_EIF3K DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398">
        <property type="entry name" value="YALI0F14311P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="389" mass="45138" checksum="37B39D6801D155A9" modified="2009-07-28" version="1">MRFGQTQNSNNRTKRGTGSDNYLGSDTNITDNDFSNSSSSLASSIEKTPPEYINNKPFKSNNTQKGIYVPPHKSKRGASSYRKKGSNSNATLTPEEQEKNKQRLARFAKSKSAPKDEFGLVSRGNDTRLRNNEHDRVEFYRQILFQFVRFCSCSTPNSLHLGLSKLINEEDYQSIDNTDSDFPKPENITMDSILLSTRKLREALLCDPPSAFHKKVFMFSVRISSVLGHYQTYIPSINYLILHRAELDLSDSEFEEIATILILHLVHLNENIPRAIQLYFRYIPHKKEILTVIQSWINGNYYHWVRIYNEERNEAILSLMKLGHDKMVRRLIKTISCCYYTLQKSDLEQNYLPHDLNFDELVSKHKINWKLSDDGKTVIIRERKKKVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGX5</accession>
    <name>C4YGX5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_03313</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the PBS2 MAP kinase kinase by phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with by SSK1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGX5"/>
    <dbReference type="PaxDb" id="5476-C4YGX5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03313"/>
    <dbReference type="HOGENOM" id="CLU_001999_0_0_1"/>
    <dbReference type="OMA" id="PPCVDEN"/>
    <dbReference type="OrthoDB" id="1043025at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06626">
        <property type="entry name" value="STKc_MEKK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000482">
        <property type="entry name" value="MAP kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045801">
        <property type="entry name" value="MEKK4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF32">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19431">
        <property type="entry name" value="MEKK4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="790"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="951"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="738"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="819"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ45007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1096" mass="124995" checksum="7FBD7931FFD23B75" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHD3</accession>
    <name>C4YHD3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="4 10">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_03479</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="10">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPK1 type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="4 10"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHD3"/>
    <dbReference type="PaxDb" id="5476-C4YHD3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03479"/>
    <dbReference type="HOGENOM" id="CLU_046294_1_0_1"/>
    <dbReference type="OMA" id="FIELRCK"/>
    <dbReference type="OrthoDB" id="272370at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.110">
        <property type="entry name" value="Inositol-pentakisphosphate 2-kinase, N-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043001">
        <property type="entry name" value="IP5_2-K_N_lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ45165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="361" mass="42906" checksum="8A7FB98782C9E203" modified="2009-07-28" version="1">MEISKITSPEDWEYFAKGAANILFKYTGNNDYLKRKLLRLRLVKQEEEYISTCELYDFIELRCKDLFPNQIIDIQLTVLDSNFTNKLNSQGNKLMLNERYGLLLPNILDGDYRKISLSQKCQLYFNDNDQDINSVIFEIKPKWLYDNYTDNYCRTCSLNQLKKVPRHFCPLDLLYTETIEQGLNDLFAPIPQDIYAKIEKLIPLKKLTTIYFNNPDNVFQKLKQYQKINNKNDLIKNLTSYSDVSQNLSLVMTLRDVGLFIKIEKFDKNNHIHTSHNNIKNVYRINDNKSNGTKDQDQEIGTNDEEDNDEKFLITCNIYDLDLKSKMKYKHWLKVENDLQEIYNSSNPNWRYCIKYDQIHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHD8</accession>
    <name>C4YHD8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHD8"/>
    <dbReference type="PaxDb" id="5476-C4YHD8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03484"/>
    <dbReference type="HOGENOM" id="CLU_811318_0_0_1"/>
    <dbReference type="OMA" id="NEIYIDC"/>
    <dbReference type="OrthoDB" id="3981267at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="342" mass="38401" checksum="AE3012F5ABDAB082" modified="2009-07-28" version="1">MEDKTKRQHSILHPLANNNQLPVRTVDTSNTADNNYNNNNSGILSSSYNPQQQHQLQQQKRPIPKNVAYPPMYSFNISTANTLKNSVSTTKATSGLPVAPDGYIYVKGYGSGSAADHIPRNIPNYYPRRGTSITNNYTESSVVTPTPLHIPRPLAPPHLLQPPNLHQSLQQPQPQQHDNGETVAAAASSPTLEIFNTLNPRKAPNMTYKEKIMNWMSSIPQFNDSENNEIYIDCYPGVISTSVTPSTSDEEIDLADIEDILELQARKVTRYVTRLYIRESENWEEIAGDDEAGDVDGGVEYEVEEGDDDDDDVDDDDYDEDRVQPHNYVYRNANLNIAYETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHG7</accession>
    <name>C4YHG7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_03513</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="SMR" id="C4YHG7"/>
    <dbReference type="PaxDb" id="5476-C4YHG7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03513"/>
    <dbReference type="HOGENOM" id="CLU_006430_0_0_1"/>
    <dbReference type="OMA" id="ENFRHIS"/>
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    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000001429">
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    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Elongator acetyltransferase complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002123">
        <property type="entry name" value="Elongator subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="56"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="100"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="198"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="609"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="657"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ45199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="797" mass="89098" checksum="BB3CF2AF8E012433" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHH1</accession>
    <name>C4YHH1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_03517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHH1"/>
    <dbReference type="PaxDb" id="5476-C4YHH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03517"/>
    <dbReference type="HOGENOM" id="CLU_1594290_0_0_1"/>
    <dbReference type="OMA" id="RIAVCIY"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ45203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="167" mass="19169" checksum="4E583086829E2B4C" modified="2009-07-28" version="1">MNEDTTQSSIQDETFLDTACQRILSLDIKGSLFGASCLNVETKILQIYEDSQINHPEVYIESLVDEFNPTIVFISSRTTTTVVSLLEDIKDVYQFKFYIKIVADFTKFDTKRLVESFYNLENNNTVHMFSTSALKSLNLRIAVCIYSSRSSGFLQRLTFPHISVRHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHJ6</accession>
    <name>C4YHJ6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Potassium channel tetramerisation-type BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_03543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
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                <person name="Lorenz M.C."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
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    </dbReference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="490" mass="57189" checksum="57E431A0BF59FB0F" modified="2009-07-28" version="1">MSKQTTTSKSKAPNSQPPPPPPPPPSSREAALMVQSSEEYNPEVPPILPHEKIYSIQVGYRLYRLSGLSLSSDAPSYFTKFFQQPENEEKVLFFDRDPQIFEKIYNHLQGYSIHIENDHIFMNLWLDCFYFGLKNLQKNLNKHDYFAIIGNERFRIPKSLINMPGNNPNFFTINFDRLLIDNINIIERNNMLRPPPQTFPPVSNRSSKLFADLLEFFRGNHLVIMNDEHRQLLIKEARYYRFLELEQRLIKFKITFRNEIVINLNDISRKGLQNPSTSYNIELPLTYYRPYIKDEMTRDLIFELNAKDFDCQSEIKLILNKSTKLPTLKVTNKACHKLHQVFKDYFSQVLKDDKGLLFFVGFTNSKTFINGKEMNSNWVNDILGIEEEEEEEDKEGEEEDKQQEAKNKDGSNKEVNKKRKVSKEDKSDKTTTTNKFSETNDPPSLSPGDIIEICLSRSLWKVMMRGPLARLHAVTLEGFTRSNDTLIDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHK4</accession>
    <name>C4YHK4_CANAW</name>
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        </submittedName>
    </protein>
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    </organism>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
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                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
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                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
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        </subcellularLocation>
    </comment>
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    <dbReference type="OMA" id="CASTVFT"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="517" mass="53685" checksum="702ECF6D741455D3" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
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                <person name="Brunke S."/>
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                <person name="Logue M.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">WO-1</strain>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039634">
        <property type="entry name" value="Bul1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007519">
        <property type="entry name" value="Bul1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904:SF1">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
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    </dbReference>
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    </dbReference>
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            <end position="590"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="95"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="178"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="672"/>
            <end position="693"/>
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        <location>
            <begin position="1"/>
            <end position="16"/>
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            <end position="54"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04425"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ45310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="693" mass="78245" checksum="94AD85FEC2899620" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHT4</accession>
    <name>C4YHT4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit C</fullName>
            <shortName evidence="4">eIF3c</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 93 kDa subunit homolog</fullName>
            <shortName evidence="4">eIF3 p93</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Translation initiation factor eIF3, p93 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NIP1</name>
        <name evidence="7" type="ORF">CAWG_03635</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit C family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHT4"/>
    <dbReference type="SMR" id="C4YHT4"/>
    <dbReference type="PaxDb" id="5476-C4YHT4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03635"/>
    <dbReference type="HOGENOM" id="CLU_004304_0_2_1"/>
    <dbReference type="OMA" id="FRCGLIK"/>
    <dbReference type="OrthoDB" id="29647at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03002">
        <property type="entry name" value="eIF3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027516">
        <property type="entry name" value="EIF3C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008905">
        <property type="entry name" value="EIF3C_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05470">
        <property type="entry name" value="eIF-3c_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="598"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="797"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="813"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="864"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ45316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="876" mass="100039" checksum="0EDD06D7B74B4A5C" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI20</accession>
    <name>C4YI20_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_03727</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI20"/>
    <dbReference type="PaxDb" id="5476-C4YI20"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03727"/>
    <dbReference type="HOGENOM" id="CLU_131066_0_0_1"/>
    <dbReference type="OMA" id="TKYDPIY"/>
    <dbReference type="OrthoDB" id="29558at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ45402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="169" mass="19055" checksum="4BC9CB8031EFF691" modified="2010-10-05" version="1">MSQLKKTNLNSVNDLRQTTDDHLGLVFQQLGYNESFTLIDLKLGLGLSTVVIAGLLFLVDKKYAWKDSYNLTVIACVLYGIISGVLYLINFFNKNVKYIGYDNKGNKLSVATSSNKLDPIYNVTISLNDRSVNAAFGFNKFFDVVGFFNRDAFTKLVENELNKLNKKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIA7</accession>
    <name>C4YIA7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="16">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_04179</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2-oxocarboxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:31763"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:31765"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 6/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="16"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIA7"/>
    <dbReference type="PaxDb" id="5476-C4YIA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04179"/>
    <dbReference type="HOGENOM" id="CLU_031922_0_1_1"/>
    <dbReference type="OMA" id="LTEVFAC"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010326">
        <property type="term" value="F:methionine-oxo-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000005">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 16 17" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="10 16" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9 15" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 17" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ45842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="393" mass="43866" checksum="A3A3F51B2369DD71" modified="2009-07-28" version="1">MILKTSSLLRSAVQSRQWLRYTSTVAPLEASKLIVEKTNNPKPKLPKDKLVFGKTFTDHMLEIEWTKEKGWHAPKISPYHNLSLDPSTIVFHYAFELFEGMKAYKDTNGNIRTFRGDKNMIRMNKSAERIALPTFEGEELQKLIDKLLLLDQDFVPEGKGYSLYLRPTLIGTTASLGVGTPDRALLYVIASPVGPYYSSGFKPVSLEATDYAVRAWPGGVGDKKLGANYAPCVKPQLEAAQRGFHQNLWLFGDEGYVTEVGTMNCFVAFENDDGTKELVTAPLDGTILEGVTRDSILELARERLPSDEWTVSERKYTIYEIEEKANKGQLIEAFGAGTAAVVSPINNIGFRGKNIKVPVALGNSGELTATVAEWIRKIQYGEEEFKNWSRVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIB8</accession>
    <name>C4YIB8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Gluconokinase</fullName>
            <ecNumber evidence="3 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_04190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-gluconate + ATP = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate acid metabolism; D-gluconate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="3 9"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIB8"/>
    <dbReference type="PaxDb" id="5476-C4YIB8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04190"/>
    <dbReference type="HOGENOM" id="CLU_077168_5_0_1"/>
    <dbReference type="OMA" id="YEGDDYH"/>
    <dbReference type="OrthoDB" id="275177at2759"/>
    <dbReference type="UniPathway" id="UPA00792"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:005248">
        <property type="entry name" value="Gluconokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442:SF3">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ45853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="191" mass="21465" checksum="D1F9E6C8EAA9DD1A" modified="2009-07-28" version="1">MTTTTTNTTVIVVGGPAGTGKTTQGELISKHFQCPFIEGDALHSQENVDKMSQGIPLTDEDRWGWLKQLSQVSSSKAHELENTTNIAVVSCSILKKKYRDFIKENSVDPLIKFRFVFLYTTFEELMSRVENRKGHYMKSDMVKSQYDIMEIPHNGELLQNGGDAITVDTSGKSPEQIFKEIIDTDNILSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIS6</accession>
    <name>C4YIS6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_04353</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="14"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ46011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIS6"/>
    <dbReference type="PaxDb" id="5476-C4YIS6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04353"/>
    <dbReference type="HOGENOM" id="CLU_008438_0_0_1"/>
    <dbReference type="OMA" id="NCHLNAP"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23285">
        <property type="entry name" value="beta-trefoil_MIR_PMT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000044">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF51">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 14 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="595"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="640"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="667"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="708"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="325"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="396"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ46011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="755" mass="86682" checksum="301025C04B8790AD" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIT2</accession>
    <name>C4YIT2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_04359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ46017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="SMR" id="C4YIT2"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04359"/>
    <dbReference type="HOGENOM" id="CLU_171960_0_0_1"/>
    <dbReference type="OMA" id="SYNIRNR"/>
    <dbReference type="OrthoDB" id="4010849at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="102" mass="11969" checksum="D39D1833A7B3C814" modified="2010-10-05" version="1">MNYTKKQKEAILNHLRLERAKVAKRNEISKKKLADQTSQKVLRRLNGVSVTLWDIKLKDIFQVERSKKLVAKNLVRDVQDMRRKLLLEQKKSPSKTTHTSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIV1</accession>
    <name>C4YIV1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein MAK16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the MAK16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ46036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIV1"/>
    <dbReference type="PaxDb" id="5476-C4YIV1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04380"/>
    <dbReference type="HOGENOM" id="CLU_050888_0_1_1"/>
    <dbReference type="OMA" id="DKGQNFC"/>
    <dbReference type="OrthoDB" id="10251342at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000001">
        <property type="entry name" value="Protein MAK16 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006958">
        <property type="entry name" value="Mak16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF4">
        <property type="entry name" value="PROTEIN MAK16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04874">
        <property type="entry name" value="Mak16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003352">
        <property type="entry name" value="MAK16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="6">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="196"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR003352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ46036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="314" mass="36806" checksum="A777EA9E19951415" modified="2009-07-28" version="1">MSDDIVWQTINHQFCAFKVKTDKGQNFCRNEYNVSGLCNRQSCPLANSRYATVKNVGGKLYLYMKTAERTHMPNRWWERIKLSKNYNKALKQIDERLQYWQKFLIHKCKQRFTRLTQVAITERRLALQEGDNERHYVGVKNKVKRREQNRERKALAAAKIEKAIEKELLERLKSGAYGDKPLNVDENIWKKVMGKVDDEQEEEDEEEFEDDIDLVSGDEDDESDVGEVEYVEDSGDDELLDMEDVEKWLGDSSDEDDGESSSSSEEESSDEEESGSRKRKSESDEKAKKKKKRRPRVEIEYEQEEEPLHTNIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ01</accession>
    <name>C4YJ01_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein HIR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_03813</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ01"/>
    <dbReference type="PaxDb" id="5476-C4YJ01"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03813"/>
    <dbReference type="HOGENOM" id="CLU_004372_3_0_1"/>
    <dbReference type="OMA" id="YEFQMEH"/>
    <dbReference type="OrthoDB" id="1741719at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000290">
        <property type="entry name" value="Protein HIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031120">
        <property type="entry name" value="HIR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011494">
        <property type="entry name" value="HIRA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019015">
        <property type="entry name" value="HIRA_B_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831">
        <property type="entry name" value="MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831:SF0">
        <property type="entry name" value="PROTEIN HIRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07569">
        <property type="entry name" value="Hira"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09453">
        <property type="entry name" value="HIRA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10 11" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="14">
        <location>
            <begin position="30"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="33"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="91"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="133"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HIRA-like C-terminal" evidence="13">
        <location>
            <begin position="687"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ45485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="853" mass="96231" checksum="60B6C73908C018D1" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ51</accession>
    <name>C4YJ51_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADPH-dependent diflavin oxidoreductase 1</fullName>
            <ecNumber evidence="10">1.18.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">NADPH-dependent FMN and FAD-containing oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TAH18</name>
        <name evidence="13" type="ORF">CAWG_03863</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 oxidized [2Fe-2S]-[protein] + NADPH = 2 reduced [2Fe-2S]-[protein] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67716"/>
            <dbReference type="Rhea" id="RHEA-COMP:17327"/>
            <dbReference type="Rhea" id="RHEA-COMP:17328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:67717"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with DRE2; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="10">Relocalizes to mitochondria after H(2)O(2) exposure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ51"/>
    <dbReference type="SMR" id="C4YJ51"/>
    <dbReference type="PaxDb" id="5476-C4YJ51"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03863"/>
    <dbReference type="HOGENOM" id="CLU_001570_17_6_1"/>
    <dbReference type="OMA" id="DIMSIPR"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160246">
        <property type="term" value="F:NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000008">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000030">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03178">
        <property type="entry name" value="NDOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028879">
        <property type="entry name" value="NDOR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 10" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 10" id="KW-0521">NADP</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="11">
        <location>
            <begin position="5"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="202"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="60"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="380"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="412"/>
            <end position="415"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="507"/>
            <end position="508"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="514"/>
            <end position="518"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="589"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ45535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="589" mass="67441" checksum="6CFDD5108E023292" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ67</accession>
    <name>C4YJ67_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_03880</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ67"/>
    <dbReference type="PaxDb" id="5476-C4YJ67"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03880"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="OMA" id="YCISIGA"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000044">
        <property type="entry name" value="Hexose transporter Hxt3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
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    </dbReference>
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        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ45797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="848" mass="98905" checksum="E615900E2CA54363" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJX8</accession>
    <name>C4YJX8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_05770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJX8"/>
    <dbReference type="PaxDb" id="5476-C4YJX8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05770"/>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="OMA" id="KNEECWA"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ47207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="392" mass="43043" checksum="679981E75CEF1008" modified="2009-07-28" version="1">MTDKTNFPTTVFVSGASGFIAQELIKQLIIKGYNVIGSVRSTTKGESIKSNLTSSSTTQSLNSDLFNYTIIKDISSPGAFDNVLKQYPEIEIFLHTASPFHFKAGNIEQELLIPAINGTKNALLAIKQFGHKIKHVVITSSVVAVGKFGKFPRTSTGSTSLSSSVVVVADENSWNPITWEMSLKNPFYGYFGSKTFAEKEVWKFLQIENPKFNITTINPGMVLGPQAFPINNHNGIGGGAGGGGGTNNLELNTSSQEIVRLLNLSTVDDVNKVKISTKVENTFIDVRDVAKAHIIAFEKPQQTKNKRLLLIEDIYNEQTLLNIINNNFPQLNLPKGEPITGQIDESKLNNTWNTTQTKTIFGDKYIGIEKSVIDSVNQILEAKNEGNPQCKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJY4</accession>
    <name>C4YJY4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_05776</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Interacts with G-actin; ADP-actin form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJY4"/>
    <dbReference type="PaxDb" id="5476-C4YJY4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05776"/>
    <dbReference type="HOGENOM" id="CLU_031995_0_2_1"/>
    <dbReference type="OMA" id="YLFKHTH"/>
    <dbReference type="OrthoDB" id="10006997at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11285">
        <property type="entry name" value="ADF_Twf-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000118">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028458">
        <property type="entry name" value="Twinfilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759:SF1">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ADF-H" evidence="9">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="ADF-H" evidence="9">
        <location>
            <begin position="212"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="367"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ47213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="406" mass="45470" checksum="72DD700505213816" modified="2009-07-28" version="1">MSTQSGITISSQLNDAYKNLSTNSALIIKISSDSTELIPDQIITGSDNTTSTTKDITILEPIFEKLTNQISQEFPHPSYIVISYNSNQYFISFIPDIAPIKQKMLYASTKNSLITSLGGNKLIKKFAWTELDELTLNYFIKSIDDDQGSNIKKEKEEELNSLLTEDEITLQKLNNLSLYSTTNHHYHGFKKKLPSMTNDDGSTTGSGNADQDILYKFTPELTEQLQSIIENSSPESSNDNDNKKSLISFNIDTTKELLTLKSIDTQIEINQLIDTLNNHTSSRISPQYILYNYQIGKLAFIYSCPSGSSVKDRMIYASFKNSLINHLNQLIKSTNIDDDIIIDKNIEVGDLDEIELSQLQDANELIHDTNTNGNNNSSSNSLSSNNSSLSSKNGLKFNKPKGPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKB6</accession>
    <name>C4YKB6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_05913</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKB6"/>
    <dbReference type="PaxDb" id="5476-C4YKB6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05913"/>
    <dbReference type="HOGENOM" id="CLU_019279_1_0_1"/>
    <dbReference type="OMA" id="GRGWDYK"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000160">
        <property type="entry name" value="Casein kinase I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="24"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="326"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="354"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ47345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="462" mass="53099" checksum="C9C9E08CCF59C2DC" modified="2009-07-28" version="1">MNFGTSHSSSSKNSHNNNVVGLHYKIGKKIGEGSFGVIFEGVNILNNAQVAIKFEPRKCEAPQLRDEYRAYKQLQGSKGIPNAYYFGQEGVHNILVIDLLGPSLEDLFDWCGRRFSIKTVIQVAIQMIRLVEQVHQQNLIYRDIKPDNFLIGKPDTPEANQIFFVDFGMAKQYRDPRTKQHIPYREKKALSGTARYMSINTHLGREQSRRDDLESLGHVFMYFLRGALPWQGLKAPTNKQKYEKIGMKKQTTSINELCYGFPIQFAQYLTYVRNLKFDETPDYQYLVGLMEKASISAGIELDGHFDWMDLNGGKGWDAALNKKANLHGYGNPYPHPSQGQRRQQQQQQEQFKQPLSSPKSQQYNSPHQPLLGNSRSRDNSLSSPRNNNKLGYQSIQQQQQDSRNAKFFNSNNAQQQQQQQAYLQQNGMIPIRDNDVELHSDMSSYTRKRSGTWLSWIFCCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKK0</accession>
    <name>C4YKK0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_06006</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle</location>
            <location evidence="6">COPII-coated vesicle membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the VMA21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKK0"/>
    <dbReference type="PaxDb" id="5476-C4YKK0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06006"/>
    <dbReference type="HOGENOM" id="CLU_154717_1_0_1"/>
    <dbReference type="OMA" id="VMAFMED"/>
    <dbReference type="OrthoDB" id="160405at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03058">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019013">
        <property type="entry name" value="Vma21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792:SF3">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09446">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ47429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="79" mass="8759" checksum="25F1B302B9049E49" modified="2009-07-28" version="1">MPAPDIPKSVIQKLMFFTALMVVFPLLTFFILQYFTDNSIISGGVAALAANVVLISYIIVAFTEDTTKLDEKDESKKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKK6</accession>
    <name>C4YKK6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_06012</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the taffazin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKK6"/>
    <dbReference type="PaxDb" id="5476-C4YKK6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06012"/>
    <dbReference type="HOGENOM" id="CLU_046747_1_1_1"/>
    <dbReference type="OMA" id="IMRYFKW"/>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00979">
        <property type="entry name" value="TAFAZZIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ47435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="410" mass="47210" checksum="A7B9FAA936067378" modified="2009-07-28" version="1">MSFQDVLKRGDEFLNDYPRTNPFWNLASHATCLFMITGSKIILNTFYKPVLHNIEKLDNALQRARDENRGLLTVMNHMSVVDDPAFYASLPWRYHLDIDTIRWGFGAHNICFSNVFQSWFFNLGKILGTKRFGEGPFQGSLDAAIRILSPDDTLDLEFTPGIKDEQKAVVLQTVNNITDCRNKELVKFIKPAPESTNVLMSKNPFIRTKTSWFHVFPEGFVLQLQEPHNNSMRYFKWGVSRLILESTRTPIVIPLFSFGFEKVAPEDSAEEGLKRWLPANFGAEIHVCIGDPIKDDVLESYREQWRSLVSKYVDKSNPTDLSDELKTGSKAQSLRSDLAGYLREKVLEIRNEIGLFNPEDKRFKDPKFWKLFTNTEGLSDPSVKFVGKNWAIKRLQSHLPEYDPSEDTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKL9</accession>
    <name>C4YKL9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="10">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAWG_06025</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="10"/>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKL9"/>
    <dbReference type="PaxDb" id="5476-C4YKL9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06025"/>
    <dbReference type="HOGENOM" id="CLU_013299_5_1_1"/>
    <dbReference type="OMA" id="MPHWLAQ"/>
    <dbReference type="OrthoDB" id="272303at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000234">
        <property type="entry name" value="DUS1p Dihydrouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="18">
        <location>
            <begin position="62"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="436"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEQ47448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="467" mass="53142" checksum="3D4D4C08D1460474" modified="2010-10-05" version="1">MKSVNSQTISNLLKVSKVMTTTKATSTTTSVSTSVATDSAFVKTKLTGRQLYNAIGQPKTIVAPMVDQSELAWRILSRRYGAQLCYTPMFHAKLFATQEKYRNSMWTTNLDGNKDLDRPLVVQFCANDPDYLLQAAKLIENECDAIDLNLGCPQGIARKGKYGAFLMDDWDLVYKLIKNLHDNLSIPVTAKIRIYDDYEKSLKYAKMVLDAGAQFITVHGRTREMKGQATGLANWKILKYLRDNLPQDQVFFSNGNILYPSDIQRCQSETACDAVMSAEGNLYNPGVFWTLDDNKDKQFPRVDKILREYFEIVKENYDSLASRHAMKSHFFKLLHAFLEVHKELRPIIGKANVNGPLDQWESIVVKIESLVQEIYSNNPDIEKLDVITNGPIEDWGGHYKTVPYWRCQPYFRKVDGVKQNTALLKMAGENELIKSIPQANNKRQLEDESNDDEGHSKLKKQATLVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKN8</accession>
    <name>C4YKN8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_06044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKN8"/>
    <dbReference type="PaxDb" id="5476-C4YKN8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06044"/>
    <dbReference type="HOGENOM" id="CLU_036827_2_1_1"/>
    <dbReference type="OMA" id="YGSVHRQ"/>
    <dbReference type="OrthoDB" id="10068368at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14232">
        <property type="entry name" value="GAT_LSB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16980">
        <property type="entry name" value="VHS_Lsb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044103">
        <property type="entry name" value="GAT_LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045007">
        <property type="entry name" value="LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789:SF1">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VHS" evidence="2">
        <location>
            <begin position="20"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ47467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="466" mass="52181" checksum="4889BB99D4BC3D0B" modified="2009-07-28" version="1">MPLFSDHAYTSITIKINQLADPKRNDEIDDSIELYLSDLIELIKVQSNSGAVEAARAIRKKIKYGDSRAEQLRALQILELLILNGGPSIGPIIARDDKLLDVLKGIINGTARTGVGVEYDCKVQKRVVAMAIGWKTELDGLDGYKYMQSLYKAIPRRKRVSSSHSGHRDRDVHDNDSDENSEDVLDPYADDAQLDSHASNRNVSSPRTPRSPPPPRPSTKSPYASGKKNDDKDKKKNKKKKKKKRGLVYADEEFEIPQINYKVEAPKIRELIANCYTHTTALNNLLLQLPADESPLDNDKTLEEFAKCKKIRRKVLSYLQYVGAGLPEAKSSEVAALDEEFLGSLIGANEQLVESFKRFDFRAGYSKDNPAPNYDDESDSDESYYTSEESEEEPDDVEEQDENSISARLQNATLQSKSPPPPRPSKPSNLQSSFQPRPKLDKVETSESIEGNPFGDRNAVTKSVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL30</accession>
    <name>C4YL30_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">biotin synthase</fullName>
            <ecNumber evidence="3">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_01544</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="13">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL30"/>
    <dbReference type="PaxDb" id="5476-C4YL30"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01544"/>
    <dbReference type="HOGENOM" id="CLU_033172_1_2_1"/>
    <dbReference type="OMA" id="NICTTHT"/>
    <dbReference type="OrthoDB" id="2414104at2759"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="BIOTIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976:SF2">
        <property type="entry name" value="BIOTIN SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01060">
        <property type="entry name" value="BATS_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00272">
        <property type="entry name" value="biotin_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01278">
        <property type="entry name" value="biotin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="14">
        <location>
            <begin position="85"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ43311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="374" mass="41694" checksum="909E8E6B6DCFF8C7" modified="2010-10-05" version="1">MSVKRFFSMNAKALRAFGSTVTSTASGFKPMPMTVSNAADTLAKARSSKPRSDWTKDEISKIYNAPLMDLIFNAQLKHREYQKPAEVQLCTLVNIKQGGCTENCSYCSQSSKHDTGVQAEKLDLDAVMDIARDAKARGGTRVCLGSAWRDMQGRKSALDKISKVVKQINDELKLETCVTLGMINEKQAEILKQNGLTAYNHNIDTSREHYPNVVTTRTYDERLETIKNVQKAGIKACTGGILGLGETAQDHVSFLYTLSNMSPHPESLPINRLVPIQGTPIVEVLKNAPKERQLEFDAILRTIATARLIMPESIIRLAAGRYTMKEHEQFLCFMSGVNAIFTGKRMLTTMCNGWDEDIAMLKKWGLKPMESFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLB1</accession>
    <name>C4YLB1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_01628</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLB1"/>
    <dbReference type="SMR" id="C4YLB1"/>
    <dbReference type="PaxDb" id="5476-C4YLB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01628"/>
    <dbReference type="HOGENOM" id="CLU_020019_1_4_1"/>
    <dbReference type="OMA" id="LALNTMH"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000014">
        <property type="entry name" value="Aquaporin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ43392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="29299" checksum="9A0CADD1C2840777" modified="2010-10-05" version="1">MVAESSSIDNTPNDVEAQRPVYEPKYDDSVNVSPLKNHMIAFLGEFFGTFIFLWVAFVIAQIANQDPTIPDKGSDPMQLIMISFGFGFGVMMGVFMFFRVSGGNLNPAVTLTLVLAQAVPPIRGLFMMVAQMIAGMAAAGAASAMTPGPIAFTNGLGGGASKARGVFLEAFGTCILCLTVLMMAVEKSRATFMAPFVIGISLFLGHLICVYYTGAGLNPARSFGPCVAARSFPVYHWIYWVGPILGSVIAFAIWKIFKILKYETCNPGQDSDA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-04-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLH0</accession>
    <name>MIC60_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MIC60</name>
        <name type="ORF">CAWG_01688</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLH0"/>
    <dbReference type="SMR" id="C4YLH0"/>
    <dbReference type="PaxDb" id="5476-C4YLH0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01688"/>
    <dbReference type="HOGENOM" id="CLU_008024_2_0_1"/>
    <dbReference type="OMA" id="RLDHQMQ"/>
    <dbReference type="OrthoDB" id="10261039at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000406649" description="MICOS complex subunit MIC60">
        <location>
            <begin position="26"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="2">
        <location>
            <begin position="26"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="2">
        <location>
            <begin position="86"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="282"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="565" mass="62596" checksum="08B8A419B90AA3B8" modified="2009-07-28" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLK1</accession>
    <name>C4YLK1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication licensing factor MCM2</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">DNA replication licensing factor mcm2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Minichromosome maintenance protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CAWG_01719</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLK1"/>
    <dbReference type="SMR" id="C4YLK1"/>
    <dbReference type="PaxDb" id="5476-C4YLK1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01719"/>
    <dbReference type="HOGENOM" id="CLU_000995_0_1_1"/>
    <dbReference type="OMA" id="TYERVTT"/>
    <dbReference type="OrthoDB" id="844at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17753">
        <property type="entry name" value="MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008045">
        <property type="entry name" value="MCM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF44">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12619">
        <property type="entry name" value="MCM2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01658">
        <property type="entry name" value="MCMPROTEIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="20">
        <location>
            <begin position="523"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="76"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="156"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="736"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="755"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00078186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EEQ43482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="903" mass="101296" checksum="08C3A4153CEFD106" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLK9</accession>
    <name>C4YLK9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TBP-associated factor 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_01728</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLK9"/>
    <dbReference type="PaxDb" id="5476-C4YLK9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01728"/>
    <dbReference type="HOGENOM" id="CLU_021602_1_0_1"/>
    <dbReference type="OMA" id="INMAIPK"/>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07981">
        <property type="entry name" value="HFD_TAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000011">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037794">
        <property type="entry name" value="TAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264:SF21">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="9">
        <location>
            <begin position="631"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="74"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="159"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="336"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="336"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="429"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="507"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="532"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ43490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="742" mass="82035" checksum="DBFF55FBAFF53FE0" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLS1</accession>
    <name>C4YLS1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_01790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLS1"/>
    <dbReference type="SMR" id="C4YLS1"/>
    <dbReference type="PaxDb" id="5476-C4YLS1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01790"/>
    <dbReference type="HOGENOM" id="CLU_035750_4_0_1"/>
    <dbReference type="OMA" id="ICMLDHH"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03755">
        <property type="entry name" value="proteasome_alpha_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000004">
        <property type="entry name" value="Proteasome subunit alpha type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="4"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ43552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="250" mass="27444" checksum="3C3477BAD1DA6A71" modified="2009-07-28" version="1">MSGYDSALSIFSPDGHVFQVEYASEAVKRGTCAVGVKGKNTVVLGCEKRTALKLQDPRITPSKICKVDHHILLAFAGLNADARILVDKARVEAQSHKLTLEDPVSVEYLTKYVAGVQQKYTQSGGVRPFGIATLIAGFDVRDDVPKLFQTEPSGVFNAWKAHAIGRSSKTVKEFLEKHYEEDLSEEETIKLTVKSLLEVVQTGAKNIEVSVLKPGAVIKKLDVDEIKKYVDAIEAEKAAEAEKKKQKSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLT3</accession>
    <name>C4YLT3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLT3"/>
    <dbReference type="PaxDb" id="5476-C4YLT3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01802"/>
    <dbReference type="HOGENOM" id="CLU_2072815_0_0_1"/>
    <dbReference type="OMA" id="NETCWTT"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="96" mass="11211" checksum="054131DD37AECCD6" modified="2009-07-28" version="1">MSNETCWTTHKHVVSQHCLRVFGIDNQIFFNREIKNRRELGLKLGSPMVGLSSLVVLLISRHLCLYLHVCLTYSNFFLIFLCIPFTPFFCRKTFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM33</accession>
    <name>C4YM33_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_01908</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ELOF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM33"/>
    <dbReference type="SMR" id="C4YM33"/>
    <dbReference type="PaxDb" id="5476-C4YM33"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01908"/>
    <dbReference type="HOGENOM" id="CLU_105983_0_3_1"/>
    <dbReference type="OMA" id="CLDANKK"/>
    <dbReference type="OrthoDB" id="445983at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.190:FF:000001">
        <property type="entry name" value="Transcription elongation factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF0">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="81"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ43664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="128" mass="14370" checksum="8343DD478C105F3D" modified="2010-10-05" version="1">MGKRKSSSRKPAKKIKQTLDTTFTCLFCNHEKSVICTIDKKNLLGELHCKICGQSFQTAIHSLSQPVDIYSDWIDACEDLAEEAEKHGNDEEGDVYSDGDDNTATNNNSGRHEKDPILDSEDEDDENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMK8</accession>
    <name>C4YMK8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_02090</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMK8"/>
    <dbReference type="PaxDb" id="5476-C4YMK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02090"/>
    <dbReference type="HOGENOM" id="CLU_005947_0_0_1"/>
    <dbReference type="OMA" id="MLRLMIW"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 10" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="632"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="698"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="761"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="826"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="910"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="180"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="304"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="404"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="524"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="540"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR002450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ43839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1058" mass="119718" checksum="A2926F173871FDB0" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMV9</accession>
    <name>C4YMV9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Striatin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_02196</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMV9"/>
    <dbReference type="PaxDb" id="5476-C4YMV9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02196"/>
    <dbReference type="HOGENOM" id="CLU_497120_0_0_1"/>
    <dbReference type="OMA" id="MKYKIVQ"/>
    <dbReference type="OrthoDB" id="727118at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="4">
        <location>
            <begin position="39"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="270"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="338"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ43940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="606" mass="68529" checksum="BE4033D09589827A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMZ6</accession>
    <name>C4YMZ6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Lysophospholipase</fullName>
            <ecNumber evidence="2 10">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_02234</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the release of fatty acids from lysophospholipids. Phospholipase B may well contribute to pathogenicity by abetting the fungus in damaging and traversing host cell membranes, processes which likely increase the rapidity of disseminated infection.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="2 10"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMZ6"/>
    <dbReference type="SMR" id="C4YMZ6"/>
    <dbReference type="PaxDb" id="5476-C4YMZ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02234"/>
    <dbReference type="HOGENOM" id="CLU_014602_0_0_1"/>
    <dbReference type="OMA" id="FARYCWN"/>
    <dbReference type="OrthoDB" id="4084751at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07203">
        <property type="entry name" value="cPLA2_Fungal_PLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000010">
        <property type="entry name" value="Lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF33">
        <property type="entry name" value="LYSOPHOSPHOLIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 9 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005125120" description="Lysophospholipase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="610"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="12">
        <location>
            <begin position="34"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ43977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="632" mass="69717" checksum="CCBCD4BDE09E0EE6" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN87</accession>
    <name>C4YN87_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_02327</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN87"/>
    <dbReference type="SMR" id="C4YN87"/>
    <dbReference type="PaxDb" id="5476-C4YN87"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02327"/>
    <dbReference type="HOGENOM" id="CLU_042324_0_1_1"/>
    <dbReference type="OMA" id="SCNYSSQ"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000015">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000107">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="41"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ44068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="323" mass="36271" checksum="AD18E753C0D05E50" modified="2010-10-05" version="1">MSKPVTLELPWVEKYRPKKLEDIVGNEETVERLKLIVQDGNMPNMIISGLPGIGKTTSIHCLAYELLGDEHYHQATMELNASDDRGIDVVRNKIKQFAQTKISLPPGRQKIIILDEADSMTPGAQQALRRTIEIYSNTTRFAFACNQSSKIIEPLQSRCAILRYNRLSDEEVLARLLEIIKMEDVKYNTEGLQALIFTAEGDMRQAINNLQSTVAGFGFVNDVNVFKIVDQPHPLVIQSILLSCLKDKDIDKALGLLDGLWYKGYSAIDIVTSTFKVAKTIPNISEQKRLDVIKEIGFAHMRVLEGVATYLQLCGLYAKICDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNC4</accession>
    <name>C4YNC4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 52D1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_01383</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNC4"/>
    <dbReference type="PaxDb" id="5476-C4YNC4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01383"/>
    <dbReference type="HOGENOM" id="CLU_001570_27_0_1"/>
    <dbReference type="OMA" id="PPAFSYI"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ43157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="538" mass="61857" checksum="2DAE55C6295D9DC4" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNF2</accession>
    <name>C4YNF2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Exportin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_01411</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNF2"/>
    <dbReference type="PaxDb" id="5476-C4YNF2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01411"/>
    <dbReference type="HOGENOM" id="CLU_011906_0_0_1"/>
    <dbReference type="OMA" id="WAFKHNN"/>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051170">
        <property type="term" value="P:import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000490">
        <property type="entry name" value="CRM1p Major karyopherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1055"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1055"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1079" mass="124043" checksum="EE1E0A3FC5F46219" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNI3</accession>
    <name>C4YNI3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Palmitoyltransferase</fullName>
            <ecNumber evidence="12">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_01445</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family. SWF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="12"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNI3"/>
    <dbReference type="PaxDb" id="5476-C4YNI3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01445"/>
    <dbReference type="HOGENOM" id="CLU_042181_2_0_1"/>
    <dbReference type="OMA" id="HIYLIWA"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF489">
        <property type="entry name" value="PALMITOYLTRANSFERASE SWF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="145"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ43216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="353" mass="40903" checksum="86CA7AEE8589D255" modified="2009-07-28" version="1">MLFTLIVCLTIISSLATFLLLFGDSPSFRNTPIQKLRNSLLSISRDIFQFYHWLDEKLNGQLLKILNWLVPVGYVMVVTVCFQQFLTHTLPMLSSPGLFRLFTIYFSMVLIYASTILATFSDPGRITTINLKSYPYTPNQLIFFDGKTCSTCHIAKPARSKHCSVCNQCFLLYDHHCVWINNCVGYYNYKWFMLFLISNINMLGYGGWLCYWALTPVSWRKITSTNNANKITGIFLILCSIFIVITTLFTFLHLRYIYLGVTTNELDKWSEIDHLVGLGVLYQIEPSIANENYVERAILDGNAVHISLKDERILIDNNNVKNFKLQLIQSVEDDLVNIYDHGFWNNLIERLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNI9</accession>
    <name>C4YNI9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flavoprotein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_01451</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNI9"/>
    <dbReference type="PaxDb" id="5476-C4YNI9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01451"/>
    <dbReference type="HOGENOM" id="CLU_014402_0_0_1"/>
    <dbReference type="OMA" id="HILLGCT"/>
    <dbReference type="OrthoDB" id="1532798at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="4">
        <location>
            <begin position="364"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="246"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="592"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="600"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ43222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="712" mass="78131" checksum="6ED5BAC7D5E45D23" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNL3</accession>
    <name>C4YNL3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_01475</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNL3"/>
    <dbReference type="SMR" id="C4YNL3"/>
    <dbReference type="PaxDb" id="5476-C4YNL3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01475"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_6_1"/>
    <dbReference type="OMA" id="FMYLNGR"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF92">
        <property type="entry name" value="AGL026WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="74"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ43246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="521" mass="57757" checksum="4D647665C0513680" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNP5</accession>
    <name>C4YNP5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine(10)-N(2))-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.214</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_02826</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.214" evidence="9"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNP5"/>
    <dbReference type="PaxDb" id="5476-C4YNP5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02826"/>
    <dbReference type="HOGENOM" id="CLU_029646_3_0_1"/>
    <dbReference type="OMA" id="AFNKWSR"/>
    <dbReference type="OrthoDB" id="296065at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160102">
        <property type="term" value="F:tRNA (guanine(10)-N2)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000260">
        <property type="entry name" value="RNA methylase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016691">
        <property type="entry name" value="TRMT11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059073">
        <property type="entry name" value="TRMT11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25904">
        <property type="entry name" value="Tmrp11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017259">
        <property type="entry name" value="tRNA_mtfrase_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00507">
        <property type="entry name" value="N12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51627">
        <property type="entry name" value="SAM_MT_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA (guanine(10)-N(2))-methyltransferase TRMT11 N-terminal" evidence="12">
        <location>
            <begin position="11"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="11">
        <location>
            <begin position="192"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ44554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="446" mass="51467" checksum="ADD1486AB5A20228" modified="2009-07-28" version="1">MDSSLANPIMKDYLIHLASTFPKFRIAELEALADLYNIDVDLSSHNEDSTFLVVSLENDEQARQLISRSVMSFGIYELWGYGETYDKLHEDVRAKSADKFEKYKDVSFKFDFKNFRGRPSNKGKVRIIESFSYLPFEGKIDLKNPDEIFTVVEEYKYNDRAKSETPTRIWFTRQLQLSERSNGLVETYDLKKRNYIGTTSFEAELSLVTCNLAQIAPGKITYDPFTGTGSFLVAAAHFGGYPIGSDIDVRMLNGKGNDKNVKSNFKQYGTSGNFIDVLTMDFTHNALRKDFQIDSIVCDPPYGVREGLRVLGAKNEEKAAGREHDVFDGEIAYLRREFIPPKKPYSLANLLEDLLQFASERLPVGGRLAFWMPTANDNFEETQIPQHERLELLHCLEQSFNQWSRRLLVYVKRDESYKGITSNGLKEKNIRDFRVRYFKRFIDKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP52</accession>
    <name>C4YP52_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_02991</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YP52"/>
    <dbReference type="SMR" id="C4YP52"/>
    <dbReference type="PaxDb" id="5476-C4YP52"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02991"/>
    <dbReference type="HOGENOM" id="CLU_047042_0_0_1"/>
    <dbReference type="OMA" id="LWCKFLQ"/>
    <dbReference type="OrthoDB" id="27198at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14351">
        <property type="entry name" value="UBA_Ubx1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF31">
        <property type="entry name" value="DCN1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DCUN1" evidence="3">
        <location>
            <begin position="66"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ44711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="304" mass="35861" checksum="933C52FDE0CEE386" modified="2009-07-28" version="1">MSKLLTSFKSSKTQLRQQFCELTGTSNTTATKYLESVRYDLARAIDNYYNKHPNKAQVTKKPVKVKIDDRLIQIFDKYKDSEDPNKIDIEGTLTYLGDLGISPDQIESLSLALLLKSPKTGVFTRENFLHIWQYYQCFDIGAMSEFITRFNKDLVNNIGGFKDISTVSDDENKSVPLKFQDLYNFTFKFSLETESQKFLDLDTAIEYWKLLLPIITETYSKDNKLDEEFKNHVNERVEQWFKFLTDTEYMTKKSISYDSWSMFYLFFKEIVLIDPIKFKDYDEMAAWPSVVDEFLEYLHDFELL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-06-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPB0</accession>
    <name>GEP3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>Genetic interactor of prohibitins 3, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Found in mitochondrial proteome protein 38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">GEP3</name>
        <name type="synonym">FMP48</name>
        <name type="ORF">CAWG_03061</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in the mitochondrial lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class YlqF/YawG GTPase family. GEP3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPB0"/>
    <dbReference type="SMR" id="C4YPB0"/>
    <dbReference type="PaxDb" id="5476-C4YPB0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03061"/>
    <dbReference type="HOGENOM" id="CLU_025792_0_0_1"/>
    <dbReference type="OMA" id="IIPPFYG"/>
    <dbReference type="OrthoDB" id="1696305at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050896">
        <property type="entry name" value="Mito_lipid_metab_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434:SF1">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000409629" description="Genetic interactor of prohibitins 3, mitochondrial">
        <location>
            <begin position="20"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="CP-type G" evidence="3">
        <location>
            <begin position="171"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="104"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="629" mass="72517" checksum="FF8644D0DB5D1E2A" modified="2009-07-28" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPP3</accession>
    <name>C4YPP3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YPP3"/>
    <dbReference type="HOGENOM" id="CLU_1932494_0_0_1"/>
    <dbReference type="OrthoDB" id="4096130at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="131" mass="14665" checksum="6451545CF7D2288C" modified="2009-07-28" version="1" fragment="single">RNDIVGVSKTVDLNQSTPIKKLPPTIPSAAPAPIPLRNKKSDNLACHADNILRMAIDSTIISSNSFTINSFEEDDDDEEGEGVDDHDHDHDFLQENSLIQLLKYKNSKRELRFKPPVIKFNINADDINSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPQ1</accession>
    <name>C4YPQ1_CANAW</name>
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        <recommendedName>
            <fullName evidence="2">DUF7082 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPQ1"/>
    <dbReference type="PaxDb" id="5476-C4YPQ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02452"/>
    <dbReference type="HOGENOM" id="CLU_009852_0_0_1"/>
    <dbReference type="OMA" id="SNGISCR"/>
    <dbReference type="OrthoDB" id="1751210at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055509">
        <property type="entry name" value="DUF7082"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463:SF1">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23305">
        <property type="entry name" value="DUF7082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7082" evidence="2">
        <location>
            <begin position="158"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
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        <location>
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            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
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            <begin position="405"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="666"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="733"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="756"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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            <end position="828"/>
        </location>
    </feature>
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        <location>
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            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="858"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="953"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1078" mass="117163" checksum="4321B26875D1ED98" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPU8</accession>
    <name>C4YPU8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Serine/threonine-protein phosphatase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_02502</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:20630"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="15"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPU8"/>
    <dbReference type="PaxDb" id="5476-C4YPU8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02502"/>
    <dbReference type="HOGENOM" id="CLU_004962_5_2_1"/>
    <dbReference type="OMA" id="CERIMHQ"/>
    <dbReference type="OrthoDB" id="445564at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000036">
        <property type="entry name" value="Serine/threonine protein phosphatase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="17">
        <location>
            <begin position="257"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ44237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="479" mass="54272" checksum="2E2F6542BFAF2277" modified="2009-07-28" version="1">MAILNHKQALENFKFILKKLPNDKLTLENYKQCTNYLKRQAFEKAIAGNDDNESIFNKIDYQSIQIEKSWSGPELNITTNTTTTTTTTTTTTTTTAGDNNNKKKSDVIVNIEGLDHDYLKYMIKLFKNGGKLPKRHVFAIIAKVYEILKQENTMTEISLLHSQIDFNNDNDDTINNPHGKGKGKGDQIIGGKKLTVVGDTHGQFFDLLNLFDKFGHVTQDHIYLFNGDFVDRGSWSCEVALYLYVLKILYPKSIFINRGNHETNDMNKTYGFTDECEFKYSKKIFEAFNQSFGALPLACLINQTYLCMHGGLFSNDKVTLKDIKSINRFPSNGSSQPPKEGLAMELLWTDPQEINGRSPSKRGIGMQFGPDITERFCLSNKIRKIIRSHEVRMNGIENEQNGRLMTVFSAPNYCDSTGNLGGVIHIEENSNYKKDLDDGQGYKTVEEKNCPWILTTETFEAVPHPDLKPMAYSKGGFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPX5</accession>
    <name>C4YPX5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_02529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPX5"/>
    <dbReference type="PaxDb" id="5476-C4YPX5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02529"/>
    <dbReference type="HOGENOM" id="CLU_059043_1_0_1"/>
    <dbReference type="OMA" id="RSKFSEW"/>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF70">
        <property type="entry name" value="PROTEIN MUM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ44264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="224" mass="26297" checksum="476A01B30C4D197F" modified="2009-07-28" version="1">MSILGDDYSPMRQCEQFSLPIINFFSWFLVWRVPTVKILLHMLKSDENWELESKSLSFVFSRLLRSKFSEWVVLFPEVNIWTPNGAALQGQVSNKYFLPKFNHLLYPRFSAFFNIISILNQSKPHAYLNMYDITILYTRNGHGTISNQYKPPTLLDIFASAEPITVIVYVKIRSVSRIPTKRKKLEKYLEHLWIHKEKVISQLKAENDTHIQSRILKDNFSVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPZ3</accession>
    <name>C4YPZ3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_02547</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
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                <person name="Stansfield I."/>
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                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">WO-1</strain>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
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        <text evidence="2">Belongs to the MAK10 family.</text>
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    <dbReference type="PaxDb" id="5476-C4YPZ3"/>
    <dbReference type="HOGENOM" id="CLU_022669_0_0_1"/>
    <dbReference type="OMA" id="ITWEFAD"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
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                <person name="Rasmussen M.D."/>
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                <person name="Sakthikumar S."/>
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                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
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                <person name="Hube B."/>
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            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
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    <sequence length="128" mass="14535" checksum="038878210A582ADF" modified="2009-07-28" version="1">MVHGVAKKKAPFGARFLMGLLMGSIDDAFYIPDLKKNLKYLENIIHKQHEKGSKYFVGDKLSGADIILEFPVITNIFQNKRGAEQLGAGDVEKEYPHLNQWAEDIKKEPKYIKAQELVAKHETVKPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
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            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
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    </organism>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
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                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
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                <person name="Fitzpatrick D.A."/>
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                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ44375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
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    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="63380" checksum="7DD443416B27216C" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ94</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
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            <taxon>Candida</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
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                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
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                <person name="Silverstein K.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">WO-1</strain>
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    </reference>
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    <proteinExistence type="predicted"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="271" mass="29528" checksum="6FDA283D6C91CB96" modified="2009-07-28" version="1">MISKLIGVTYFKNKLSKHSSKHDDNTSNNNSSNDTSFPTTNSTALPSKRSSICLSHRIKSKRNSSTSSTTSSSSSSPPPTPTTLTSSSTRKVVTRSQIRRSNTISSASALRHSLNVSNSNTIPTSIPKKSFSLPNSPSLTSDSTLNEPIDDIPHFYNTTMDINGAGNKYYGLISSTNNLMGRDGLLTLDLTTGNDTNSLFTTATREKLDNDSIIIDQQEQEEYNKGNEHMYGYGYGYELTNNTAVAAVEGTKIASLARSISKMKKKNVRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQH6</accession>
    <name>C4YQH6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_02734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQH6"/>
    <dbReference type="PaxDb" id="5476-C4YQH6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02734"/>
    <dbReference type="HOGENOM" id="CLU_1461119_0_0_1"/>
    <dbReference type="OMA" id="RCATDIN"/>
    <dbReference type="OrthoDB" id="10301422at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031426">
        <property type="entry name" value="DUF4667"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15700">
        <property type="entry name" value="DUF4667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ44465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="172" mass="19536" checksum="EE1C843057994EB4" modified="2009-07-28" version="1">MTCQTGRKCSLGIEEPIDISSKNVPLNAFLIYTMSSTLPDHNSTNSWNEYHNNLSITNNTQVTTSCADNVKTTSNVPRCATDINSKMTTSELETLHRCRFSVCDFNNLENYLYQSEREECSRVIEQLETHNGKSISTCCNSNTDINAQCNQMKNHKRRKSIALKFKKPQTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQN7</accession>
    <name>C4YQN7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Fatty acid synthase subunit alpha</fullName>
            <ecNumber evidence="19">2.3.1.86</ecNumber>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="19">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
                <ecNumber evidence="19">1.1.1.100</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">3-oxoacyl-[acyl-carrier-protein] synthase</fullName>
                <ecNumber evidence="19">2.3.1.41</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="27" type="ORF">CAWG_02796</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The alpha subunit contains domains for: acyl carrier protein, 3-oxoacyl-[acyl-carrier-protein] reductase, and 3-oxoacyl-[acyl-carrier-protein] synthase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 19">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 19">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 19">Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.86" evidence="19"/>
    <dbReference type="EC" id="1.1.1.100" evidence="19"/>
    <dbReference type="EC" id="2.3.1.41" evidence="19"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YQN7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02796"/>
    <dbReference type="HOGENOM" id="CLU_000114_0_0_1"/>
    <dbReference type="OMA" id="FPTLPDW"/>
    <dbReference type="OrthoDB" id="4251012at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00828">
        <property type="entry name" value="elong_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08950">
        <property type="entry name" value="KR_fFAS_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.20:FF:000005">
        <property type="entry name" value="Fatty acid synthase alpha subunit FasA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2490:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.25.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040899">
        <property type="entry name" value="Fas_alpha_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047224">
        <property type="entry name" value="FAS_alpha_su_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026025">
        <property type="entry name" value="FAS_alpha_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041550">
        <property type="entry name" value="FASI_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18325">
        <property type="entry name" value="Fas_alpha_ACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18314">
        <property type="entry name" value="FAS_I_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000454">
        <property type="entry name" value="FAS_yeast_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 22" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 19 23" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="25">
        <location>
            <begin position="127"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="26">
        <location>
            <begin position="1099"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="20">
        <location>
            <position position="1282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="1749"/>
            <end position="1751"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="1749"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="1750"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="1751"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1775"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1785"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="1794"/>
            <end position="1810"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="1818"/>
            <end position="1821"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="1848"/>
            <end position="1850"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="1849"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="1850"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="23">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00060261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="EEQ44526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1863" mass="205643" checksum="D8099DEA1F674B07" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQQ7</accession>
    <name>C4YQQ7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coatomer subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_04404</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the COPE family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQQ7"/>
    <dbReference type="PaxDb" id="5476-C4YQQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04404"/>
    <dbReference type="HOGENOM" id="CLU_058871_0_0_1"/>
    <dbReference type="OMA" id="SWVGMRE"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001863">
        <property type="entry name" value="Coatomer subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016478">
        <property type="entry name" value="Coatomer_esu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ46060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="311" mass="35620" checksum="B79C307C0A8D24C7" modified="2009-07-28" version="1">MDAFSDSGELYTIRNQFYTNQHNKVKAYSLDEFSPENQLKVLEFQIRSTIALEQDASKMIEDGKTRFPENEPLFQLLSAWNDLKDFGVDDSTYFEDVKKASFELQAVLTALYLVKFDKDIDQAITFLSDYIDNVNSLAKYNELEPFLVLVQLYLIKGNLTGATKVLQNLNQFPESARDNIVYQVLESWILSVTGGSDNINNSYYFYDEILSSDFDQDIQGKFKILNVLFALTLQLKHFPEAQELLEQIKGLGVVDANFIANQITFDQLQNDGANTAELLNELKRLDASHELLKEQDLKTSIFDDIVTKYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQW7</accession>
    <name>C4YQW7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">S-adenosylmethionine decarboxylase proenzyme</fullName>
            <ecNumber evidence="12">4.1.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_04464</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>S-adenosyl-L-methionine + H(+) = S-adenosyl 3-(methylsulfanyl)propylamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:15981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="4.1.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="12"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQW7"/>
    <dbReference type="PaxDb" id="5476-C4YQW7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04464"/>
    <dbReference type="HOGENOM" id="CLU_023050_0_0_1"/>
    <dbReference type="OMA" id="CYQRKNE"/>
    <dbReference type="OrthoDB" id="1068353at2759"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.90.10:FF:000011">
        <property type="entry name" value="S-adenosylmethionine decarboxylase proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001985">
        <property type="entry name" value="S-AdoMet_decarboxylase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018166">
        <property type="entry name" value="S-AdoMet_deCO2ase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00535">
        <property type="entry name" value="SAM_DCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001355">
        <property type="entry name" value="S-AdenosylMet_decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01336">
        <property type="entry name" value="ADOMETDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 16" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="4 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10 12" id="KW-0704">Schiff base</keyword>
    <keyword evidence="6 12" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5042322442" description="S-adenosylmethionine decarboxylase beta chain" evidence="17">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042322441" description="S-adenosylmethionine decarboxylase alpha chain" evidence="17">
        <location>
            <begin position="81"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="13">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for catalytic activity" evidence="13">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="13">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="13">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autolysis" evidence="16">
        <location>
            <begin position="80"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="15">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ46120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="384" mass="43999" checksum="2C8E90F8983CE1A7" modified="2009-07-28" version="1">MVAPALIYSNHELSTAIDSTHAFEGPEKLLEIWFYESKELSPINLRDIKFDTWIEILNLVHCEVLSKVSSNLCDAFLLSESSLFVFPHKIILKTCGTTTTLACLDLLFETVNKELLQNEGLKATFQSKNIYQIFYSRRSFMFPDRQIHVHGNWQEEVKLLNQYFNNGKSYIVGNNTNWHLYVGGNGKTKNPVASTTTTTTTTTPVVNDCTLEIIMTQLSLEASQQFYTTRKPGDTAIDSNHDLGHDLGQEILKQTGLNELFKFKKQPTMPRLSSFPVKEIHDGFAFTPCGFSSNSINESNYYTIHVTPEPGWSYASFETNMIGDYKAIVDKCINVFQPGQFMVTFLTNTDMEKFECCLDNYKVNHREELDVEDYKLYFVEFVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR10</accession>
    <name>C4YR10_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADP-ribose 1''-phosphate phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_04508</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ADP-alpha-D-ribose 1''-phosphate + H2O = ADP-D-ribose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:25029"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:58753"/>
            <dbReference type="EC" id="3.1.3.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the POA1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.84" evidence="2"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR10"/>
    <dbReference type="PaxDb" id="5476-C4YR10"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04508"/>
    <dbReference type="HOGENOM" id="CLU_054419_1_2_1"/>
    <dbReference type="OMA" id="CQGSWGK"/>
    <dbReference type="OrthoDB" id="2155246at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140291">
        <property type="term" value="P:peptidyl-glutamate ADP-deribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02901">
        <property type="entry name" value="Macro_Poa1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050892">
        <property type="entry name" value="ADP-ribose_metab_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12521:SF0">
        <property type="entry name" value="ADP-RIBOSE GLYCOHYDROLASE OARD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12521">
        <property type="entry name" value="PROTEIN C6ORF130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="5">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ46163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="156" mass="17458" checksum="27BAE14A72423F20" modified="2009-07-28" version="1">MIQYIKSDLFTHAIPAGKKVILAHACNTRGSWGGGIAAVFRKKFPKANNEYSQYCHKNSNLLGTSFIIESDQPNILIACLFTSDFNQTPEQIVHFTKQSIADLARKVSDYKEVEKCDGKAAINMPKINAGIFGVPWEDTESALQEFDNLHFNVYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR65</accession>
    <name>C4YR65_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR65"/>
    <dbReference type="PaxDb" id="5476-C4YR65"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04564"/>
    <dbReference type="HOGENOM" id="CLU_172679_0_0_1"/>
    <dbReference type="OMA" id="NTIMTEL"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="134" mass="16047" checksum="C77705373BFF16CB" modified="2009-07-28" version="1">MKVLLLLLYAYLFVSYTSFFFFLIKCYFILYNRNTIMTELQCLTVKFKYEVLFLIHCPATMTSFVCTYRLFGHAFLICCITTCVKDFKCYGRTKCLFLNSITVFYWYQRNNSSIQIIKIYLVSIYFENSNIPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRC8</accession>
    <name>C4YRC8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRC8"/>
    <dbReference type="PaxDb" id="5476-C4YRC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04627"/>
    <dbReference type="HOGENOM" id="CLU_017832_0_0_1"/>
    <dbReference type="OMA" id="YPLPISW"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="781" mass="87879" checksum="285599A6FBA82ABA" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRF0</accession>
    <name>C4YRF0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">JAB1/MPN/MOV34 metalloenzyme domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRF0"/>
    <dbReference type="PaxDb" id="5476-C4YRF0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04649"/>
    <dbReference type="HOGENOM" id="CLU_027018_0_0_1"/>
    <dbReference type="OMA" id="QDVIMIE"/>
    <dbReference type="OrthoDB" id="25498at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000149">
        <property type="entry name" value="Translation initiation factor eIF3 subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF6">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JAB1/MPN/MOV34 metalloenzyme" evidence="2">
        <location>
            <begin position="27"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="337" mass="37482" checksum="292A356BF22D5215" modified="2009-07-28" version="1">MSQTNSFMHLVRPNVIAPAAGSANGPASIKIHAPAMLTILEIISQQVLNKRIIGTLLGSRSDDGLEMEIKDGFMVPINETGDSIAIEDQVHKSLYQLYKKAHPKETVLGWFGSSNQIDDITSLIHDFYSKGVDRAFPFPAIYLNVEFLNEKNQIIEPKITTYIGAAVGKPVSNTQQIGWKTTNVNNSYIFTPIPNEVINATITEKIAFKTLIDQKINQQNDNTNTNTNTNNNNGNNNNTDDLSYLSQQLNKATDNVGQLLSYIENNGNKDQDIDLLRLLSNQLLNKPAILTNLPELEKLFKDHNQDVIMIEYLTKAVKDQIELSARLTASAEADKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRH2</accession>
    <name>C4YRH2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidant-induced cell-cycle arrest protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04672</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OCA5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRH2"/>
    <dbReference type="PaxDb" id="5476-C4YRH2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04672"/>
    <dbReference type="HOGENOM" id="CLU_412174_0_0_1"/>
    <dbReference type="OMA" id="FHLRDYM"/>
    <dbReference type="OrthoDB" id="206700at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000173">
        <property type="entry name" value="GTPase-activating protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1310:FF:000013">
        <property type="entry name" value="Gyp8p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045913">
        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913:SF7">
        <property type="entry name" value="RE60063P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="657"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="6">
        <location>
            <begin position="78"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="614"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="614"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ46325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="757" mass="86168" checksum="DCD6071B4A727D8A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRI2</accession>
    <name>C4YRI2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U4/U6.U5 tri-snRNP-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04682</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNU66/SART1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRI2"/>
    <dbReference type="PaxDb" id="5476-C4YRI2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04682"/>
    <dbReference type="HOGENOM" id="CLU_018358_0_0_1"/>
    <dbReference type="OMA" id="FNGRHYR"/>
    <dbReference type="OrthoDB" id="5583at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000481">
        <property type="term" value="P:maturation of 5S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045347">
        <property type="entry name" value="HIND"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005011">
        <property type="entry name" value="SNU66/SART1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152">
        <property type="entry name" value="SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNISED BY CYTOTOXIC T LYMPHOCYTES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152:SF5">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19252">
        <property type="entry name" value="HIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03343">
        <property type="entry name" value="SART-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="444"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="633"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="635"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="648"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ46335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="675" mass="77166" checksum="FD932EC947098D0F" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRW1</accession>
    <name>C4YRW1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Arginase</fullName>
            <ecNumber evidence="2 12">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_04818</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>L-arginine + H2O = urea + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9 12">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="2 12"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRW1"/>
    <dbReference type="SMR" id="C4YRW1"/>
    <dbReference type="PaxDb" id="5476-C4YRW1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04818"/>
    <dbReference type="HOGENOM" id="CLU_039478_6_1_1"/>
    <dbReference type="OMA" id="YKEFRYA"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000012">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="242"/>
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        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ46464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="317" mass="34329" checksum="787507A7270BC30A" modified="2010-10-05" version="1">MSSIQYKYHPDKKASIITAPFSGGQPKGGVELGPDYILKAGFQKQIESLGWTTDLKEPLEGTDYEKMKTNDKDDFGVKNSKIVSESCQKIHDAVKGSLAEGKLPITIGGDHSIGTATVSASLVHDPSTCVVWVDAHADINTPKTTDSGNLHGCPLSFIMGIDRDSYPPEFSWVPQVLKSNKLVYIGLRDVDDGEKEILRKHNIAAFSMYHVDKYGIGKVVEMALDKVNPNRDCPVHLSYDVDAIDPSFVPATGTRVEGGLSLREGLFIAEEIAQSGLLQSLDIVETNPMLAETEEHVLDTVSAACAIGRCALGQTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS24</accession>
    <name>C4YS24_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcineurin subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Calcineurin regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Protein phosphatase 2B regulatory subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_04882</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="4275" last="4275">
            <title>Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents.</title>
            <authorList>
                <person name="Juvvadi P.R."/>
                <person name="Fox D."/>
                <person name="Bobay B.G."/>
                <person name="Hoy M.J."/>
                <person name="Gobeil S.M.C."/>
                <person name="Venters R.A."/>
                <person name="Chang Z."/>
                <person name="Lin J.J."/>
                <person name="Averette A.F."/>
                <person name="Cole D.C."/>
                <person name="Barrington B.C."/>
                <person name="Wheaton J.D."/>
                <person name="Ciofani M."/>
                <person name="Trzoss M."/>
                <person name="Li X."/>
                <person name="Lee S.C."/>
                <person name="Chen Y.L."/>
                <person name="Mutz M."/>
                <person name="Spicer L.D."/>
                <person name="Schumacher M.A."/>
                <person name="Heitman J."/>
                <person name="Steinbach W.J."/>
            </authorList>
            <dbReference type="PubMed" id="31537789"/>
            <dbReference type="DOI" id="10.1038/s41467-019-12199-1"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) IN COMPLEX WITH CA(2+)</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Composed of a catalytic subunit (A) and a regulatory subunit (B).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PDB" id="6TZ6">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.55 A"/>
        <property type="chains" value="B/E=1-173"/>
    </dbReference>
    <dbReference type="PDBsum" id="6TZ6"/>
    <dbReference type="AlphaFoldDB" id="C4YS24"/>
    <dbReference type="SMR" id="C4YS24"/>
    <dbReference type="PaxDb" id="5476-C4YS24"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04882"/>
    <dbReference type="HOGENOM" id="CLU_061288_10_1_1"/>
    <dbReference type="OMA" id="DTNFDRD"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
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    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="13" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="1 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="130"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="67"/>
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        <ligand>
            <name>Ca(2+)</name>
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            <label>1</label>
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        <ligand>
            <name>Ca(2+)</name>
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            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
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    </feature>
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            <label>2</label>
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        <ligand>
            <name>Ca(2+)</name>
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            <label>2</label>
        </ligand>
    </feature>
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        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
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            <name>Ca(2+)</name>
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            <label>3</label>
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        <location>
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        <ligand>
            <name>Ca(2+)</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
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        <ligand>
            <name>Ca(2+)</name>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023754"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ46527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="6TZ6"/>
        </source>
    </evidence>
    <sequence length="173" mass="19435" checksum="72BC8F26E58CF109" modified="2009-07-28" version="1">MGANASILDGFIEDTNFSIEEIDRLRKRFMKLDKDGSGQIDKQEFLSIPGISSNPLATRLMDVFDKDGDGSIDFEEFITGLSAFSGKSDNLNKLRFAFNIYDIDRDGYIGNGELFIVMKMMVGKNLKDEELQQIVDKTLMEADLDGDGKLNFEEFKNAVNTDTIANTLTLNMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS56</accession>
    <name>C4YS56_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_04915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS56"/>
    <dbReference type="PaxDb" id="5476-C4YS56"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04915"/>
    <dbReference type="HOGENOM" id="CLU_3147149_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="49" mass="5405" checksum="C57843AB86F72AB3" modified="2009-07-28" version="1" fragment="single">IISNMYPDDFNISSSELCSLVWRFSGMVGGNKGVIKLFLLVYATFVSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSB2</accession>
    <name>C4YSB2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Reduced viability upon starvation protein 167</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04975</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSB2"/>
    <dbReference type="PaxDb" id="5476-C4YSB2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04975"/>
    <dbReference type="HOGENOM" id="CLU_025518_0_1_1"/>
    <dbReference type="OMA" id="QEYDYYN"/>
    <dbReference type="OrthoDB" id="2159336at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07599">
        <property type="entry name" value="BAR_Rvs167p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000048">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000100">
        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="6">
        <location>
            <begin position="17"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="382"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="286"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="337"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ46615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="440" mass="49190" checksum="2C4E9EA93EAFEA18" modified="2009-07-28" version="1">MSFKGFKKGVLRAPQTMRQKFNMGEITQDAVYLDAERRFKEIETETKKLSEESKKYFNAVNGMLDEQIDFAKAVAEIYKPISGRLSDPSATVPEDNPQGIEASESYQAVVKDLKDTLKPDLELIEKRIVEPAQELLKIIQAIRKMSVKRDHKQLDLDRHKRNLSKYESKKERTVKDEEKMFSAQAEVEIAQQEYDYYNDLLKNELPVLFQMQSDFIKPLFVSFYYMQLNIFYTLYTRMEELKIPYFDLSTDIVEAYTAKKGNIEEQTDAIGITHFKVGHAKSKLEATKRRHAAMNSPPPTGASSIASTGTGGELPAYSPGGYNQPYGDSKYQPPSSPATYQSPVVAATAQSPATYQSPVATGQPPSYLPQTPASAPPPQVGSGLPTCTALYDYTAQAQGDLTFPAGAVIEIIQRTEDANGWWTGKYNGQTGVFPGNYVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSM9</accession>
    <name>C4YSM9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pep3/Vps18 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_05097</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSM9"/>
    <dbReference type="PaxDb" id="5476-C4YSM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05097"/>
    <dbReference type="HOGENOM" id="CLU_003488_0_0_1"/>
    <dbReference type="OMA" id="WIQREKW"/>
    <dbReference type="OrthoDB" id="1845386at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007810">
        <property type="entry name" value="Pep3/Vps18_beta-prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF26">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05131">
        <property type="entry name" value="Pep3_Vps18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pep3/Vps18 beta-propeller" evidence="5">
        <location>
            <begin position="39"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="4">
        <location>
            <begin position="512"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ46732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="810" mass="94406" checksum="622960246DDF7733" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSR6</accession>
    <name>C4YSR6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aurora kinase</fullName>
            <ecNumber evidence="9">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_05135</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="9"/>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSR6"/>
    <dbReference type="PaxDb" id="5476-C4YSR6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05135"/>
    <dbReference type="HOGENOM" id="CLU_000288_20_0_1"/>
    <dbReference type="OMA" id="ESRFPEW"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001230">
        <property type="entry name" value="Spindle assembly checkpoint kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="235"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="42"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="53"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="180"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="362"/>
            <end position="363"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="8">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ46769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="521" mass="59517" checksum="CF414AC6AFF8B93F" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT11</accession>
    <name>C4YT11_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL27m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">54S ribosomal protein L2, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_05709</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT11"/>
    <dbReference type="PaxDb" id="5476-C4YT11"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05709"/>
    <dbReference type="HOGENOM" id="CLU_063752_0_0_1"/>
    <dbReference type="OMA" id="YLDPFHP"/>
    <dbReference type="OrthoDB" id="1867012at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000042">
        <property type="entry name" value="50S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_bL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_bL27_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041244">
        <property type="entry name" value="Ribosomal_bL27m_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL27M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18471">
        <property type="entry name" value="Ribosomal_L27_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL27m C-terminal" evidence="10">
        <location>
            <begin position="139"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ47147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="389" mass="44540" checksum="8869DFE100BDD9CA" modified="2009-07-28" version="1">MSSFVKGLFSHTRKSIDLTSNPLHTSIQIRTAKKRVSGSRTNNKDSAGRRLGPKKNEGHFVNPGQIIMRQRGTKIHPGDNVKIGVDHTIFAVEPGYVRYYFDPFHPLRKYVGVSLKKNLKLPRPHFEPRLRRFGYVQITDPIEAQEEEASQSRKEMLAQPELEKLKEKKLNEKIQFIESTKTALVNEFGFDSEPSSKQLEDASERLYNIYQLRASGQSLSEARIQTTFNTLYDLKLQAQKNNIDSLPNLLNEAKEFITKIDSIVGIEPTGELFKNLTKEEQLNLQKEISSELDTLYQTKALEKDYRIEAKKLINTPGVFEPLQREELMAKYLPQVLPMDYPGSVIEISDSDSKNKNKKLSENIVIQRIFDETTRKVKLIGRPKEAFASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT23</accession>
    <name>C4YT23_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_05721</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT23"/>
    <dbReference type="SMR" id="C4YT23"/>
    <dbReference type="PaxDb" id="5476-C4YT23"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05721"/>
    <dbReference type="HOGENOM" id="CLU_027543_3_1_1"/>
    <dbReference type="OMA" id="GYAQEYL"/>
    <dbReference type="OrthoDB" id="238681at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000040">
        <property type="entry name" value="8-oxoguanine glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.40:FF:000001">
        <property type="entry name" value="N-glycosylase/DNA lyase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000005">
        <property type="entry name" value="N-glycosylase/DNA lyase OGG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="12">
        <location>
            <begin position="131"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ47159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="353" mass="40945" checksum="56F97B8C42D9B0DC" modified="2010-10-05" version="1">MTVETIWKSLPITEVEVSLQKVLRCGQTFRWKNINNVWSFTIQDRIVLLKQDSTHIHYSQVMKKDTNGNHKQTLDFINDYFVLDTKLTDLYTHWKLQHEPFRSKKISPFDSFAGIRILRQDPWECLISFICSSNNNVKRISKMCENLCINFGDYINDFEGHEYYTFPTPEALSKPNVEAKLRDLGFGYRAKYIYQTACKFTDNNKYPDITIENLNLLREAKYTTAHEFLLQLTGVGPKVADCICLMSLDKHDVVPIDTHVYQIAVRDYKFKGNKSMKTLNKETYAAIRLFFKDIFGEYAGWAQSVLFAADLADLNNGTNITDTTTTTTTTTISDQIEPSRKRIKVERQIKVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT27</accession>
    <name>C4YT27_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone-binding protein RBBP4-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_05725</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT27"/>
    <dbReference type="SMR" id="C4YT27"/>
    <dbReference type="PaxDb" id="5476-C4YT27"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05725"/>
    <dbReference type="HOGENOM" id="CLU_020445_3_1_1"/>
    <dbReference type="OMA" id="CEADWHP"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="8">
        <location>
            <begin position="74"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="340"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="443"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="451"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="468"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ47163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="485" mass="55308" checksum="6E9EA57F05298F24" modified="2010-10-05" version="1">MFSRPLEEMSKEQDMTKEKKMDYKTNNFRKTISQHLLSFRYQQLHIMPSSTNEFAKAERELVEEQQLQEKIVNEEFKIWKKTVPLLYDFIHTFALDNPSLVFQWLPTTSVSQSDLELKFLIGTNAINKSENYLKLTSISLPSTLVGATDSIPVPSDGIDTSNFKVVTQWKQTQEINKLKVSPNGSLAVGFSADGVIRSYNLDNFDSVDYKYHKQGGIALDWVDNNGFLSGSNDAQIALWQVDKSSTPLQLFKGHHGAINDISSIKEKHLFGSVSDDSTTQFHDTRVNATDINPVITVENSHIQNCIQFHPDIQTLYATGGKDNVVSLYDIRNYSTPFRKFYGHNDSVRQLQWDWNNPDILVSCGLDKRIIFWDLKNLDEDFTYPDATSNGKDTNSKRKQAVKTDPCLKYVHGGHTRRTNDFDIHPKVKNIFGSVGDDKLLEIWKPKSLPGDEPEQESTEVQEDEEMKDAETKGVKDGEEDTKMKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT71</accession>
    <name>C4YT71_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT71"/>
    <dbReference type="PaxDb" id="5476-C4YT71"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05357"/>
    <dbReference type="HOGENOM" id="CLU_000680_27_2_1"/>
    <dbReference type="OMA" id="DCHADIC"/>
    <dbReference type="OrthoDB" id="4097129at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="156" mass="17552" checksum="C9307ECB9D2AB1ED" modified="2009-07-28" version="1">MINSKIWHNNQHGFIPGRTIQDVTQKLATTIDAIRRHTSSNHAVILIDFRKAFDNINCLYLLLTLTKLNIDDDTIRYCMAVTADHFGQIQLNNRLSSSFKLRQGNPLSPALFNIGLEPLLHKIDQTLTAVKLENGYSVNVLAYADDITIFVDNEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT94</accession>
    <name>C4YT94_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_05380</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT94"/>
    <dbReference type="PaxDb" id="5476-C4YT94"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05380"/>
    <dbReference type="HOGENOM" id="CLU_009646_8_2_1"/>
    <dbReference type="OMA" id="MKWTHIA"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF692">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="530"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="565"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="192"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ46835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="588" mass="64463" checksum="0624D8920D011E9D" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTS8</accession>
    <name>C4YTS8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fmp45p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTS8"/>
    <dbReference type="PaxDb" id="5476-C4YTS8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05573"/>
    <dbReference type="HOGENOM" id="CLU_059603_2_0_1"/>
    <dbReference type="OMA" id="FPFHIIA"/>
    <dbReference type="OrthoDB" id="5419460at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032185">
        <property type="term" value="P:septin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36414">
        <property type="entry name" value="PROTEIN SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36414:SF1">
        <property type="entry name" value="PROTEIN SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ47019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31183" checksum="BD2332CD47FC3B39" modified="2009-07-28" version="1">MRALNIIPVFFLVGSVLLLILTIINGAGTSSVLGKFYWSETDTSGLTGVPYNKTRWTFYRMCGVDHNKNAHCGKSQAAFPYSPEDNFGRNSGIPQNFIDDRDTYYYLSRVGWAFILVGLFFGVAAMVAAPLNFCYFVAGIVGSTTAFVSLLFTITAACCITAAHTKGRREWNRAGFPTVLGAKAFGILWTAVACLLISFVSLVVLTCLSRTSTRRRNRGVGVTNGSEVTPRGEQETYAKESSGEIPRGEYESGNHPVTGPGEGERLSNASKFRFFRVKRAKSEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTU7</accession>
    <name>C4YTU7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peroxisomal ATPase PEX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peroxin-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Peroxisome biosynthesis protein PAS1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_05593</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the PEX1-PEX6 AAA ATPase complex involved in peroxisome biosynthesis. The complex acts as a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling. Specifically recognizes PEX5 monoubiquitinated at 'Cys-6', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel. Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTU7"/>
    <dbReference type="PaxDb" id="5476-C4YTU7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05593"/>
    <dbReference type="HOGENOM" id="CLU_000688_1_1_1"/>
    <dbReference type="OMA" id="LSASWCA"/>
    <dbReference type="OrthoDB" id="2187at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19526">
        <property type="entry name" value="RecA-like_PEX1_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000432">
        <property type="entry name" value="AAA family ATPase peroxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000024">
        <property type="entry name" value="AAA family ATPase peroxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000149">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015342">
        <property type="entry name" value="PEX1-N_C-lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF12">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09262">
        <property type="entry name" value="PEX-1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="490"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="764"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="185"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1067"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ47038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1087" mass="121075" checksum="A4A6FFEA348BA6AF" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTY5</accession>
    <name>C4YTY5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_05633</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF48">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1032"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="281"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="612"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="768"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="901"/>
            <end position="953"/>
        </location>
    </feature>
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        <location>
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            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
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            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
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            <end position="387"/>
        </location>
    </feature>
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        <location>
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            <end position="639"/>
        </location>
    </feature>
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            <end position="790"/>
        </location>
    </feature>
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    </feature>
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    </feature>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ47076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1320" mass="148044" checksum="48C8E56D889A1E3C" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C5K452</accession>
    <name>C5K452_CANAW</name>
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        <recommendedName>
            <fullName evidence="2">Argininosuccinate lyase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06155"/>
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    <dbReference type="OrthoDB" id="2561043at2759"/>
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        <property type="component" value="Unplaced Supercontig 1.13"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
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    </dbReference>
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        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="125"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ43134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="150" mass="16905" checksum="080FA82ED5FEFD61" modified="2009-07-28" version="1">MSIKSIPSTYNKDMQEDKEPLFDALTTVEHSILIATGVISTLSIDKQNMEKALTMDMLATDLADYLVRKGVPFRETHHISGECVRKAEEEKLSGIDQLSFEQFQQIDSRFEKDVMETFDFEASVERRDAIGGTAKSAVLKQLENLKSILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCS0</accession>
    <name>C4YCS0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
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</entry>
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                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD36"/>
    <dbReference type="PaxDb" id="5476-C4YD36"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00424"/>
    <dbReference type="HOGENOM" id="CLU_067891_3_0_1"/>
    <dbReference type="OMA" id="RIEVKCM"/>
    <dbReference type="OrthoDB" id="10267305at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21372">
        <property type="entry name" value="cwf21_CWC21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CWF21" evidence="9">
        <location>
            <begin position="69"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="109"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="130"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ42222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="162" mass="18889" checksum="8907180B792E703D" modified="2009-07-28" version="1">MSYNGIGLQSVRGSATSGHIQKNIANKISKPGHYESRKNQKSLMSKRADEAKQSQNKREAYKQIKSELTKHEQLRRIEVKCMDLHDELEEQGVEPDEIKARVDELRKKLNNKEFDENDAKSPTTTAPQPSRKDKQLKEDLENENKNKDGVFEYKRRYTDKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD51</accession>
    <name>C4YD51_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD51"/>
    <dbReference type="PaxDb" id="5476-C4YD51"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00441"/>
    <dbReference type="HOGENOM" id="CLU_070630_0_0_1"/>
    <dbReference type="OMA" id="CEIKCTP"/>
    <dbReference type="OrthoDB" id="4002732at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990444">
        <property type="term" value="F:F-box domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062026">
        <property type="term" value="P:negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070372">
        <property type="term" value="P:regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052449">
        <property type="entry name" value="STYX-Interacting_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588">
        <property type="entry name" value="SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588:SF1">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="254" mass="29393" checksum="AE360474030C722F" modified="2009-07-28" version="1">MFFNPETPQQICPRVWLGPHNALLNNTDNYGSNFLVQRNIKIIINCGTTLPFLDLIENNRDVAISSDVLILSLDPFFQSHDELAANFTRKYSRILANYLNYFYKSNPNAAKLIHQLPNSTDRIQISSPILCGANLMMQFFSLIRLINLFKSINQEMEVLIISQDGNDNLSTGLMIAYLMDTYRYNLLNSFNMIKSRRPSIYDWSSVEYDALLKQFYTQNCEIKCTPLMDTIKRSSQEDDSELMAGGDRKRRFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDA9</accession>
    <name>C4YDA9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_00499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDA9"/>
    <dbReference type="SMR" id="C4YDA9"/>
    <dbReference type="PaxDb" id="5476-C4YDA9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00499"/>
    <dbReference type="HOGENOM" id="CLU_006033_1_2_1"/>
    <dbReference type="OMA" id="YYDEQLA"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF25">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 14 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="59"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ42295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="297" mass="32637" checksum="261860A6405002C0" modified="2009-07-28" version="1">MTPAPTSTLATTEKPNTKTSSKGYQIDENSFHKLAIGGSLPNQYPKFTDKLQERKFILEHTAATFRIFARNGFNEGVAGHCSVRDPLEPNTFWINPLGLHFALIRAEDLVHVDEDGNILPDGNQDPINAAGFAIHSSLHKARPDVNAACHTHSLYGRAYSAFGKPLEMINQDSCTFFNNQAVYNSFGGVAIEKDEGKAIAEAAGDARAVILQNHGLLTMGKTIDEAAYLFMLMEKTCHAQLLADAAESKDKPKQYIADSEAEYTARITSNPAILYTVFQSDYKLEERLSNGDFKFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDB2</accession>
    <name>C4YDB2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDB2"/>
    <dbReference type="PaxDb" id="5476-C4YDB2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00502"/>
    <dbReference type="HOGENOM" id="CLU_486581_0_0_1"/>
    <dbReference type="OMA" id="KECMIRI"/>
    <dbReference type="OrthoDB" id="4016411at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="33"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="561" mass="63467" checksum="5ADD02268A0989AF" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDH2</accession>
    <name>C4YDH2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Squalene monooxygenase</fullName>
            <ecNumber evidence="4 10">1.14.14.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_00567</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>squalene + reduced [NADPH--hemoprotein reductase] + O2 = (S)-2,3-epoxysqualene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25282"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the squalene monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.17" evidence="4 10"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDH2"/>
    <dbReference type="SMR" id="C4YDH2"/>
    <dbReference type="PaxDb" id="5476-C4YDH2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00567"/>
    <dbReference type="HOGENOM" id="CLU_026390_0_0_1"/>
    <dbReference type="OMA" id="AKRTFYW"/>
    <dbReference type="OrthoDB" id="1678617at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004506">
        <property type="term" value="F:squalene monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013698">
        <property type="entry name" value="Squalene_epoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040125">
        <property type="entry name" value="Squalene_monox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835:SF0">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08491">
        <property type="entry name" value="SE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene epoxidase" evidence="11">
        <location>
            <begin position="192"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ42358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="496" mass="55298" checksum="C844CE43A679B920" modified="2009-07-28" version="1">MSSVKYDAIIIGAGVIGPTIATAFARQGRKVLIVERDWSKPDRIVGELMQPAGIKALRELGMIKAINNIRAVDCTGYYIKYYDETITIPYPLKKDACITNPVKPVPDAVDGVNDKLDSDSTLNVDDWDFDERVRGAAFHHGDFLMNLRQICRDEPNVTAVEATVTKILRDPSDPNTVIGVQTKQPSGTVDYHAKLTISCDGIYSKFRKELSPTNVPTIGSYFIGLYLKNAELPAKGKGHVLLGGHAPALIYSVSPTETRVLCVYVSSKPPSAANDAVYKYLRDNILPAIPKETVPAFKEALEERKFRIMPNQYLSAMKQGSENHKGFILLGDSLNMRHPLTGGGMTVGLNDSVLLAKLLHPKFVEDFDDHQLIAKRLKTFHRKRKNLDAVINTLSISLYSLFAADKKPLRILRNGCFKYFQRGGECVNGPIGLLSGMLPFPMLLFNHFFSVAFYSVYLNFIERGLLGFPLALFEAFEVLFTAIVIFTPYLWNEIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEB7</accession>
    <name>C4YEB7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Golgi pH regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_00872</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
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    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
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            <end position="25"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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            <dbReference type="Pfam" id="PF12537"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ42653.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="582" mass="65288" checksum="228143D7E8E326BC" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEG9</accession>
    <name>C4YEG9_CANAW</name>
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        <name evidence="3" type="ORF">CAWG_00926</name>
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        <lineage>
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    </organism>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
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        </source>
    </evidence>
    <sequence length="308" mass="34561" checksum="9F6E204FB441232A" modified="2009-07-28" version="1">MHRTYSLRSSKAPTASQLQSPPPPPSSTKNKFFGSGGLSSTIRKAAAGATGPELSRKLSQFIKMEKNFMRAVEVTSRERKDVAKQLSAWGEDNEDDISDVTDKLGVLIYEIGELEDQYIDKYDQYRITLKSIRDIEGSVQPSRDRKQKITDEIAHLKYKDPQSPKIPVLEQELVRAEAESLVAEAQLSNITREQLKAAFNYQFDATRELAEKYALIAGYGKALLELLDDSAVTPGETRPAYDGYEASKQIIIDAENALASWTLDSAAVKPTLSLHQEYDEDELEHEHGEIDDAAQEEFNKHDENVEHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEN1</accession>
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        <recommendedName>
            <fullName evidence="2">Mating factor alpha precursor N-terminal domain-containing protein</fullName>
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    </organism>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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                <person name="Rasmussen M.D."/>
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                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
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                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
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                <person name="Brunke S."/>
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                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
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                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42767.1"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946569" description="Mating factor alpha precursor N-terminal domain-containing protein" evidence="1">
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            <begin position="19"/>
            <end position="143"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ42767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="143" mass="15495" checksum="BD967FEB82374753" modified="2010-10-05" version="1">MKFSLTLLTATIATIVAAAPAQYTGQAIDSNQVVEIPESAVEAYFPIDDELTPVFGEIDNKPVILIVNGTTLTSGANNEKREAKSKGGFRLTNFGYFEPGKRDANADAGFRLTNFGYFEPGKRDANAEAGFRLTNFGYFEPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YET8</accession>
    <name>C4YET8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trehalose-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_01046</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YET8"/>
    <dbReference type="SMR" id="C4YET8"/>
    <dbReference type="PaxDb" id="5476-C4YET8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01046"/>
    <dbReference type="HOGENOM" id="CLU_002351_3_0_1"/>
    <dbReference type="OMA" id="VHPMPIE"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1020:FF:000003">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000131">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF123">
        <property type="entry name" value="TREHALOSE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="852"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="872"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ42824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="888" mass="100407" checksum="157ABDDAA26C64C9" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEZ7</accession>
    <name>C4YEZ7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEZ7"/>
    <dbReference type="SMR" id="C4YEZ7"/>
    <dbReference type="PaxDb" id="5476-C4YEZ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01106"/>
    <dbReference type="HOGENOM" id="CLU_054590_1_0_1"/>
    <dbReference type="OMA" id="CATCFFP"/>
    <dbReference type="OrthoDB" id="58297at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562:SF2">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="252" mass="28382" checksum="C3A960F0ABD162F9" modified="2010-10-05" version="1">MRIYVYHPKIPNYPKVKFPGVLVYSEIYQVTGPVSRFAKDIAGQGFIVACPSSYHNFVGPEPLAYDVEGTDIGNQYKIEKELKSYDEDTNLTIEYLLSLPTCNGKLGATGMCLGGHLAYRAALDPRVQATVCFFATDIHSKSLGKGKNDDSLERCGEIKGEIILIFGCKDNHVPLEGRDLIRGELRKKNVEMTFIEINDAQHAFVRDELSKGRYDPATTKLCFEWLFELFNRKLKLDYGDHDGKDVVIENVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFL3</accession>
    <name>C4YFL3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_01331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFL3"/>
    <dbReference type="PaxDb" id="5476-C4YFL3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01331"/>
    <dbReference type="HOGENOM" id="CLU_048444_0_0_1"/>
    <dbReference type="OMA" id="HNRTRTY"/>
    <dbReference type="OrthoDB" id="2152248at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF0">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="37285" checksum="4A80C326ECCFC2E9" modified="2010-10-05" version="1">MKEFQFDPESFSKVTYNIGGISTYIYNSDKLASYVEKFNKFDHPIEAIPINVIYLIHHRGGSHKHTEAIAYNYLKQFYDKKSQDYDIPLICVTFDNPNHGQRLVNEHSNSDWAENNETHGADMMSIIEGTIQNIRLIMDYLPSYLNLDSYLSDKFKRINPGTEIKFHNILTGYSLGGHVVIRYGIDYPHDVKIIGPVVGCSDLTSLLVTRLKSITNNDKKYFYFNYDELDLTDEQKKQYPETLHKRISKQDQAIFENYPMNKIKMFASFGSEDKLVPHSLSSVWCDFYLSTNSAASIYVAEGVGHDVTDEMIDRFTTWLAKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFN3</accession>
    <name>C4YFN3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="9">26S proteasome regulatory subunit RPN11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_00009</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFN3"/>
    <dbReference type="SMR" id="C4YFN3"/>
    <dbReference type="MEROPS" id="M67.A10"/>
    <dbReference type="PaxDb" id="5476-C4YFN3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00009"/>
    <dbReference type="HOGENOM" id="CLU_052991_0_1_1"/>
    <dbReference type="OMA" id="KTGRHEM"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="8">
        <location>
            <begin position="33"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ41822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="312" mass="34956" checksum="83BF94B781B8B5E2" modified="2010-10-05" version="1">MERLQRLLGQGAGLGGAAPTQSDGPAIDNSETVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDFTIHVHDVFAMPQSGTGVSVEAVDDVFQTKMMDMLRQTGRDQMVVGWYHSHPGFGCWLSSVDVNTQQSFEQLNKRAVAVVIDPIQSVKGKVVIDAFRTIDTTTLMMGQEPRQSTSNVGHLNKPSIQALIHGLNRHYYSLNIDYHKTEYETNMLLNLHKKNWQSGLKLVDYNHKEVENLDNTEKMVSIAKLYNQRVQEEKELTEDQLKTRYVGKQDPKKHLSDTAEKLIDENVSSLLTSNIDAVAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFU3</accession>
    <name>C4YFU3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_00069</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Eukaryotic pyruvate dehydrogenase (PDH) complexes are organized as a core consisting of the oligomeric dihydrolipoamide acetyl-transferase (E2), around which are arranged multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide dehydrogenase (E3) and protein X (E3BP) bound by non-covalent bonds.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFU3"/>
    <dbReference type="PaxDb" id="5476-C4YFU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00069"/>
    <dbReference type="HOGENOM" id="CLU_035825_2_1_1"/>
    <dbReference type="OMA" id="NRFEVYD"/>
    <dbReference type="OrthoDB" id="202158at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.320.10:FF:000017">
        <property type="entry name" value="Pyruvate dehydrogenase complex protein X component, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF82">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE COMPLEX PROTEIN X COMPONENT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="10">
        <location>
            <begin position="26"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="11">
        <location>
            <begin position="165"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="116"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ41882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="413" mass="45556" checksum="B347EAB024C69215" modified="2009-07-28" version="1">MLRAAFTRRTVNQIRAFHGSSIYYAASVFKMPAMSPTMSEGGIVSWKVKPGDTFSAGDPILEVETDKATIDVEAADDGKLWEILVNEGTSGVPVGKPIAFLAEQDDDLSTLEKPSIEDVKQETQAPAPQEKKPEEKTTKKEVKQSAPREVSTGSSVLQKANPNQKLSPAVELLLHENNISNEDAFAKIQASGPKGRILKGDVLAYLGKIDTGVVVELTEFLKSREHLDLSKIVLAEPSKTEESTESKSSKEEKAKVEKPKPKNILSVELTSNLGEDISQSKFKFAFEKSISAAIRQTYASKFPQFAQSPTASSIYDKYDVFDEILSAPVTKNRFEVFDIKYKFYGEESSKNKVSADSFDELLGLSTPVQYLETGSSNVNVSFKIKFDDKLQDSKLFVENFENSLLSQIPANKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFX1</accession>
    <name>C4YFX1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14 15">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="3 14 15">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_01359</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:23733"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="3 14 15"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFX1"/>
    <dbReference type="SMR" id="C4YFX1"/>
    <dbReference type="PaxDb" id="5476-C4YFX1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01359"/>
    <dbReference type="HOGENOM" id="CLU_040369_4_2_1"/>
    <dbReference type="OMA" id="LTLHAMM"/>
    <dbReference type="OrthoDB" id="10253702at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000018">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 15" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="17">
        <location>
            <begin position="8"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="16">
        <location>
            <begin position="191"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR015950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ43122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="362" mass="39544" checksum="C1E3FE2AC040C8D3" modified="2009-07-28" version="1">MYSASVTAPVNIATLKYWGKRDKSLNLPTNSSISVTLSQDDLRTLTTASASESFEKDQLWLNGKLESLDTPRTQACLADLRKLRASIEQSPDTPKLSQMKLHIVSENNFPTAAGLASSAAGFAALVSAIAKLYELPQDMSELSKIARKGSGSACRSLFGGFVAWEMGTLPDGQDSKAVEIAPLEHWPSLRAVILVVSDDKKDTPSTTGMQSTVATSDLFAHRIAEVVPQRFEAMKKAILDKDFPKFAELTMKDSNSFHAVCLDSYPPIFYLNDTSKKIIKMVETINQQEVVAAYTFDAGPNAVIYYDEANQDKVLSLLYKHFGHVPGWKTHYTAETPVAGVSRIIQTSIGPGPQETSESLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGL9</accession>
    <name>C4YGL9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGL9"/>
    <dbReference type="PaxDb" id="5476-C4YGL9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03198"/>
    <dbReference type="HOGENOM" id="CLU_026673_16_1_1"/>
    <dbReference type="OMA" id="RICGVTH"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="11"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="358" mass="39198" checksum="C251C7130B99B73D" modified="2009-07-28" version="1">MKAAVVPISIKDNYLTEIKDISKPEIKDDQILIKAKACAINPIDWKHIVYQMSKPGDVAGSDVSGIVEQVGANVTNFKKGDLVSSFVMGNMSPMSGAFAEYVAAFPQATIKYDHDLDNPPKAKASMIDSFEGAASITMGLTTVAQSFSHSLNIPKHKKPGDSILIWSGATATGIVAIQVAKLVYNLKVITTASPRNHEYLKELGADFTLDYKDPKIVDKLKSLGHIKFGLDTIATPQTFQKLYDATQGTPEVYLDSLLGMDGNSIKTDPARETTVHWGHTMGYLCVLKTKTLGSTTYVQSTELLNDYNKWWENVMPTIIDKIKHANLKILPNGLESANEGLQMSRESKVSGEKIVFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGR6</accession>
    <name>C4YGR6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U2 small nuclear ribonucleoprotein A'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_03248</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the U2 small nuclear ribonucleoprotein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGR6"/>
    <dbReference type="SMR" id="C4YGR6"/>
    <dbReference type="PaxDb" id="5476-C4YGR6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03248"/>
    <dbReference type="HOGENOM" id="CLU_061027_3_0_1"/>
    <dbReference type="OMA" id="PNYREYM"/>
    <dbReference type="OrthoDB" id="433501at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001728">
        <property type="entry name" value="Component of U2 snRNP, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044640">
        <property type="entry name" value="RU2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552:SF6">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ44948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="233" mass="27168" checksum="4B207D7EBAADBD1C" modified="2009-07-28" version="1">MRLTAQVINEAPEILNPEGKLTLLLRDLQITELENLAITQNKYQVIDLSNNDLISLGNIPKRFNNLQCLLLSNNNISYIDDESFPSDNHITSITLFNNNIYQFQKSFKDKFPKLETLILLGNPITEMENYRYFIIWLIPSLKVLDFKKVKQAERKTSEDMFGTNRDEFNSLAQQMFKNENTEIKLDGKSDRQVKNFVKKMTDEERQQLLKKLETATSIEEIERIENDLKEGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGV1</accession>
    <name>C4YGV1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aminodeoxychorismate synthase</fullName>
            <ecNumber evidence="4">2.6.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Para-aminobenzoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">p-aminobenzoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_03285</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11672"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58406"/>
            <dbReference type="EC" id="2.6.1.85"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.85" evidence="4"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGV1"/>
    <dbReference type="MEROPS" id="C26.958"/>
    <dbReference type="PaxDb" id="5476-C4YGV1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03285"/>
    <dbReference type="HOGENOM" id="CLU_006493_0_0_1"/>
    <dbReference type="OMA" id="DWSVNIR"/>
    <dbReference type="OrthoDB" id="64220at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008153">
        <property type="term" value="P:4-aminobenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF18">
        <property type="entry name" value="AMINODEOXYCHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="10">
        <location>
            <begin position="3"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="12">
        <location>
            <begin position="285"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="11">
        <location>
            <begin position="502"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="11">
        <location>
            <begin position="602"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ44983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="802" mass="92160" checksum="CAD829F1B3461A34" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGY8</accession>
    <name>C4YGY8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA decay factor PAT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_03329</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PAT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGY8"/>
    <dbReference type="PaxDb" id="5476-C4YGY8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03329"/>
    <dbReference type="HOGENOM" id="CLU_012622_1_0_1"/>
    <dbReference type="OMA" id="YLEHSGH"/>
    <dbReference type="OrthoDB" id="74835at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039900">
        <property type="entry name" value="Pat1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019167">
        <property type="entry name" value="PAT1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551:SF0">
        <property type="entry name" value="PROTEIN ASSOCIATED WITH TOPO II RELATED-1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551">
        <property type="entry name" value="TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09770">
        <property type="entry name" value="PAT1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="mRNA decay factor PAT1" evidence="8">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA decay factor PAT1" evidence="8">
        <location>
            <begin position="64"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA decay factor PAT1" evidence="8">
        <location>
            <begin position="523"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="93"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="273"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="302"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF09770"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ45020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="800" mass="90179" checksum="B833C0720C5CCD66" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGZ6</accession>
    <name>C4YGZ6_CANAW</name>
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        <submittedName>
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    <organism evidence="2 3">
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        <name type="common">Yeast</name>
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            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
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                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
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                <person name="Lorenz M.C."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000001429">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="607" mass="70820" checksum="80EB165484EBCAED" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH18</accession>
    <name>C4YH18_CANAW</name>
    <protein>
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        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein pxr1</fullName>
        </alternativeName>
    </protein>
    <gene>
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    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
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                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
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                <person name="Sherlock G."/>
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            <dbReference type="PubMed" id="19465905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINX1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EEQ45050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03359"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0003676">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF31">
        <property type="entry name" value="PROTEIN PXR1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="G-patch" evidence="10">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="152"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="173"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ45050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="273" mass="31021" checksum="53CECFF446F94024" modified="2009-07-28" version="1">MGLAGTKIKQRFGNDPRNTNWSNDTSRFGHQYLAKMGWQQGSGLGLVSHALTTHVKVSIKDDNLGLGAKLHKRKANGDGGLEEEGTAGLDAFQRILGRLNGKENVVNKVLDNVRDDDIINGKWGMRFVKGETLSSTWDKESKKLISYKNIEDDGKKSRKRKADESETKEDKKTLKKHKKEKKDKKEKKEKKKKKEKKDKKDKKNKKDKKDKKDKKDKKDKIRTGSDETLVSKESSATPPPIATRLSARSKWIKQKRASVMDSKALNEIFMITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHB5</accession>
    <name>C4YHB5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ECE1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHB5"/>
    <dbReference type="SMR" id="C4YHB5"/>
    <dbReference type="PaxDb" id="5476-C4YHB5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03461"/>
    <dbReference type="HOGENOM" id="CLU_1019397_0_0_1"/>
    <dbReference type="OMA" id="HAPEFNM"/>
    <dbReference type="OrthoDB" id="4024249at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="29101" checksum="B8EE966A35F0CCE9" modified="2009-07-28" version="1">MKFSKIACATVFALSSQAAIIHHAPEFNMKREVVPAGQGDPAPGPEPQLAPAPQDVNTAITKRSIISIIMGILTNIPQVIQIIMSIVRAFKGNKREDIDSVVAGIIADMPFVARAVDTAMTSVASTKRDGVNDDVANAVVRLPEIVARVATGVQQSVENAKRDGVPDIGLNLVANAPRLFSDVFDGVSETVQQAKRDGIEDALNELLEQLPKLITRSAESALKDSQPVKRDAGSVALSNLIKKSIETVGVENVAQIVSERDIASLIEEYFGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHM0</accession>
    <name>C4YHM0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHM0"/>
    <dbReference type="PaxDb" id="5476-C4YHM0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03568"/>
    <dbReference type="HOGENOM" id="CLU_061859_0_0_1"/>
    <dbReference type="OMA" id="YGYHVRI"/>
    <dbReference type="OrthoDB" id="361029at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase-C9orf114-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150">
        <property type="entry name" value="CLASS IV SAM-BINDING METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150:SF13">
        <property type="entry name" value="METHYLTRANSFERASE C9ORF114-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="41510" checksum="C8448EAF9D034F73" modified="2009-07-28" version="1">MAKRKATESEPLPTKKPTKSVSETTISICIPSTVISSKNAYNLQQITNIIYQIAKACTIYKVAEIIVFDVPQSNNDKEDDKSTVVVGSKVKFVEDEPEKTLANPSKKSNVNGDKVSPSLLVASLLQFFITPPYLVKTMFSSHLNSKFKNILPKFTYAFKLPKITTLPFMQNNQVYKDFKEGMIIPRETPLMKKKNKKTKSDHKITVSKYVNIGEKEALKLDIKREIPIYSRVTVDLKNKTVVSPLQAYGVVGHKAAFGYHVRMASEFNKIFTQSPISDGYSSTIYVNCDDYFGNNNKISELDNLSTFKEATGNVLMVLGNYKDLQAGFKADTSNVFENIDSVAHLFDSKLNIPDGCRIEDAILISLAKVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHN2</accession>
    <name>C4YHN2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_03580</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHN2"/>
    <dbReference type="PaxDb" id="5476-C4YHN2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03580"/>
    <dbReference type="HOGENOM" id="CLU_162151_1_0_1"/>
    <dbReference type="OMA" id="VGENMQK"/>
    <dbReference type="OrthoDB" id="274922at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038:SF16">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="14">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ45264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="91" mass="10052" checksum="EAD59FBF981153E4" modified="2009-07-28" version="1">MFGLGGTTPQISSQQKLQAAEAELDMVTGMFNALVSQCHTKCINKSYNEADISKQESLCLDRCVAKYFETNVQVGENMQKLGQSGQFIGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHQ1</accession>
    <name>C4YHQ1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_03600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHQ1"/>
    <dbReference type="SMR" id="C4YHQ1"/>
    <dbReference type="PaxDb" id="5476-C4YHQ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03600"/>
    <dbReference type="HOGENOM" id="CLU_015355_3_0_1"/>
    <dbReference type="OMA" id="MQAFCIA"/>
    <dbReference type="OrthoDB" id="260807at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="566"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ45283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="600" mass="65322" checksum="997D25A7BE20973D" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHU7</accession>
    <name>C4YHU7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHU7"/>
    <dbReference type="PaxDb" id="5476-C4YHU7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03650"/>
    <dbReference type="HOGENOM" id="CLU_2263357_0_0_1"/>
    <dbReference type="OMA" id="MKFTTNC"/>
    <dbReference type="OrthoDB" id="10325600at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946505" evidence="1">
        <location>
            <begin position="25"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="109" mass="11587" checksum="AAEFF3335AD64D70" modified="2009-07-28" version="1">MKFTTNCLSFLLLTTLLLSESTNGLINPHTLIANTANIKRNAVTAADDPVDRTITHYGVPQTDSATRFQSSMTVETANSTVSAHNNGNQLQIVTGAPIIAVMGLVLGLF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI11</accession>
    <name>MMM1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Maintenance of mitochondrial morphology protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MMM1</name>
        <name type="ORF">CAWG_03718</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MMM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI11"/>
    <dbReference type="SMR" id="C4YI11"/>
    <dbReference type="PaxDb" id="5476-C4YI11"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03718"/>
    <dbReference type="HOGENOM" id="CLU_032730_2_0_1"/>
    <dbReference type="OMA" id="WSFTQGL"/>
    <dbReference type="OrthoDB" id="5599157at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21671">
        <property type="entry name" value="SMP_Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03103">
        <property type="entry name" value="Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027537">
        <property type="entry name" value="Mmm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019411">
        <property type="entry name" value="MMM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF0">
        <property type="entry name" value="SMP-LTD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10296">
        <property type="entry name" value="MMM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0445">Lipid transport</keyword>
    <keyword id="KW-0446">Lipid-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000384220" description="Maintenance of mitochondrial morphology protein 1">
        <location>
            <begin position="1"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="98"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="1">
        <location>
            <begin position="165"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="439" mass="49026" checksum="2DA845B53E62F56C" modified="2009-07-28" version="1">MSQDLIETTATTTKIVEARELGHQIHDSLLEQLKLQQEELLQQQRDLFFQEQQLQLQQQVTQPVSNNGNTWSFTQGLVIGQVSVIFIIIVFVKFFVFADSSSHIPTKPGLDGAIGVIVKRNKNKKHSNGQFANDGENEDDTSLDSNQSKISSILEKTYYDVNNHASESLDWFNVLVAQTISQLRSEALLKDNIYHSLNNFLTNAKLPDFIDTINLTEIDIGDDFPIFSNCRIKYGEDLKRLEAKIDVDLSDTLTLGIATKLLLNQPRPLTAVLPVSLTVSIVRFSGCLTVSLINTKDIDLKNVDKTSNMNGYSKENANGDGASSSNNDEDEDDGGTALMFSFSPDYRLEFIVKSLIGSRAKLQDVPKISSLIENQLRTWFIERCVEPRFQVVRLPSLWPRTKNTREPVTKKTTTTPSTTVNGTSAATITTPGEYVNSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIE7</accession>
    <name>C4YIE7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_04220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIE7"/>
    <dbReference type="PaxDb" id="5476-C4YIE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04220"/>
    <dbReference type="HOGENOM" id="CLU_000288_88_4_1"/>
    <dbReference type="OMA" id="CQPDKPD"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000087">
        <property type="entry name" value="Dual specificity tyrosine-phosphorylation-regulated kinase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="436"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="22"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="148"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="715"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="719"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ45882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="819" mass="93088" checksum="94513F5A5817A28F" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIE9</accession>
    <name>C4YIE9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit TIM17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_04222</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Mitochondrion inner membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIE9"/>
    <dbReference type="PaxDb" id="5476-C4YIE9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04222"/>
    <dbReference type="HOGENOM" id="CLU_087811_3_0_1"/>
    <dbReference type="OMA" id="FDCTFQY"/>
    <dbReference type="OrthoDB" id="2261329at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005678">
        <property type="entry name" value="Tim17"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00980">
        <property type="entry name" value="3a0801so1tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF0">
        <property type="entry name" value="AT05822P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ45884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="154" mass="16299" checksum="B842C8F0472456B4" modified="2010-10-05" version="1">MSADHTRDPCPIVILNDFGGAFAMGVIGGCVWHGIKGFRNSPYGERSYGALSAIKARAPVVGGNFGVWGGLFSTFDCTVKAVRKREDAWNAVIAGFFTGGALAIRGGWKHTRNSAITCACLLGVFEGVGMMMQRLQAQPTMAPVYPEEPTALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIF9</accession>
    <name>C4YIF9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_04232</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIF9"/>
    <dbReference type="PaxDb" id="5476-C4YIF9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04232"/>
    <dbReference type="HOGENOM" id="CLU_009125_2_1_1"/>
    <dbReference type="OMA" id="WAMQLIS"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000421">
        <property type="entry name" value="Serine/threonine-protein kinase PAK 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="372"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="553"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="615"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="484"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="555"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="662"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="684"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="736"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ45894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="809" mass="87195" checksum="6E896B413B355A5A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIL2</accession>
    <name>C4YIL2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gag1-like clamp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIL2"/>
    <dbReference type="PaxDb" id="5476-C4YIL2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04288"/>
    <dbReference type="HOGENOM" id="CLU_049905_0_0_1"/>
    <dbReference type="OMA" id="RTYNIHI"/>
    <dbReference type="OrthoDB" id="5576875at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053274">
        <property type="entry name" value="Fluconazole_resistance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025124">
        <property type="entry name" value="Gag1-like_clamp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28065:SF1">
        <property type="entry name" value="DUF4050 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28065">
        <property type="entry name" value="FREQUENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13259">
        <property type="entry name" value="clamp_Gag1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gag1-like clamp" evidence="2">
        <location>
            <begin position="280"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ45947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="372" mass="42791" checksum="F4CD08E0B867A090" modified="2009-07-28" version="1">MTNEVQSVNNFPISTKSKQELLRKSKSTPRLRGISSPVTSSSTLPTSTPTTNTKKKQKRKQSTTTNNSSGGIPGFFRKISTEWNSFVSKLKSISDDVLTTDDIAEEFFIEEDSDDTGFDRLMRSHRGYTSTEEKFLQEYKKYKSLDTMAAAYQKNQHNKNNNNNNSGYSNDIRTYNIHISDPTNMSSNFTGSSNKVHYTLQDIMRQQQSQSQQQQPQRPFSETPLLPNGEEFEILDEDDEDGESTAAEIVYNDIDMIELRKEFEMWVNNKNTSDTDSKSTLFSQSNIGTTLWEYRRNKWLICNDPEKTETRLKETSITHIPKESYAKIYNNLIEKNKTLKHNKHINLSDLVKIINAGWIAEEKWDRAARGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIQ7</accession>
    <name>C4YIQ7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="11">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_04333</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11 14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="11"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIQ7"/>
    <dbReference type="SMR" id="C4YIQ7"/>
    <dbReference type="PaxDb" id="5476-C4YIQ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04333"/>
    <dbReference type="HOGENOM" id="CLU_023296_1_1_1"/>
    <dbReference type="OMA" id="HGTVQRH"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000002">
        <property type="entry name" value="Isocitrate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="6 11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 11 14" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11 15" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="16">
        <location>
            <begin position="38"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="104"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="123"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="338"/>
            <end position="343"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ45992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="433" mass="48589" checksum="7C43600E70553A41" modified="2009-07-28" version="1">MIRTTTTRAINRTAMLQNHIRGFSSTASILDKIKVKNPIVELDGDEMTRIIWQKIKDQLILPYLDVNLKYYDLGIESRDATNDQITIDAANAIKEHGVGVKCATITPDEARVKEFNLKKMWLSPNGTIRNILGGTVFRESIIIPCIPRLIPGWKEPIVIGRHAFGDQYKATDLVINEPGKLELRFTPENGGETQTHKVYDYTGPGVGLAMYNTDESISGFARASFNMALSKNLPLYMSTKNTILKKYDGRFKDIFQDIYENEYASEFEKKGLWYEHRLIDDMVAQMIKSKGGFVMALKNYDGDVQSDIVAQGFGSLGLMTSALMTPDGKAYEAEAAHGTVTRHYRQHQQGKETSTNSIASIFAWTRGLAQRGRLDETPEVVDFADKLEKATIDTVEVDRIMTKDLALAMGKTDRSAYVTTTEFLDAVADRLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ10</accession>
    <name>C4YJ10_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_03822</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ10"/>
    <dbReference type="PaxDb" id="5476-C4YJ10"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03822"/>
    <dbReference type="HOGENOM" id="CLU_087338_1_0_1"/>
    <dbReference type="OMA" id="IAHVHAN"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15843">
        <property type="entry name" value="R-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000203">
        <property type="entry name" value="Synaptobrevin (V-SNARE), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="113"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ45494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="208" mass="23983" checksum="3A49989D3AE4ACB2" modified="2009-07-28" version="1">MYFMKKLLSNQDGSRDLITVVAIAHVHANKTLVLNVLKNIMDKYIEYKREFDSNKSASGQSSKAKLGEFKLYMNQIIKYEEMNYDSNQHIYNYGSTNENNEDGHPADQINPNQLLLANEEVDEVRQLMLENINKLLSRGDKINSLVDQTDRLNTSSSVFQKRAQQIKRKMWFMKTKFLLSITGGVLLILYLFIGSECGFPAFSHCIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ26</accession>
    <name>C4YJ26_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_03838</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ26"/>
    <dbReference type="PaxDb" id="5476-C4YJ26"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03838"/>
    <dbReference type="HOGENOM" id="CLU_020088_4_2_1"/>
    <dbReference type="OMA" id="PWMQFYQ"/>
    <dbReference type="OrthoDB" id="409173at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037982">
        <property type="entry name" value="Nramp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF29">
        <property type="entry name" value="IRON TRANSPORTER SMF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="485"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ45510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="514" mass="56376" checksum="1BFF5198A9705A49" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ59</accession>
    <name>C4YJ59_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ59"/>
    <dbReference type="PaxDb" id="5476-C4YJ59"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03871"/>
    <dbReference type="HOGENOM" id="CLU_1245191_0_0_1"/>
    <dbReference type="OMA" id="WELNAGV"/>
    <dbReference type="OrthoDB" id="4017608at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944737" evidence="1">
        <location>
            <begin position="21"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="222" mass="25264" checksum="5EED2B6F73F6FA26" modified="2009-07-28" version="1">MYKLILLTWLCLLPIQMVSSSDSTKKLFPKTDVNDLVYFNQVFDMATKQTSDPDPDSYVENSNKTITLITLDKPPNNDTNAVDAQFKKKKGKLKPKWELNAGVYLEKKVNKKLLKKSKKKNSKKFGILTKDNGDAERILIPAELMVSRATPGTHNLFSQNSSNYPFQLTKINVTSIRKAPVLSTSIAHEVSDINHGIVEFSIASKVFDKFWNQIFWAFLYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJJ0</accession>
    <name>C4YJJ0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aspartate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="4">1.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_04005</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the NADPH-dependent formation of L-aspartate 4-semialdehyde (L-ASA) by the reductive dephosphorylation of 4-phospho-L-aspartate. Mediates the second step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-aspartate 4-semialdehyde + phosphate + NADP(+) = 4-phospho-L-aspartate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:24286"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="4"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJJ0"/>
    <dbReference type="PaxDb" id="5476-C4YJJ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04005"/>
    <dbReference type="HOGENOM" id="CLU_049966_1_0_1"/>
    <dbReference type="OMA" id="CEEEMKM"/>
    <dbReference type="OrthoDB" id="1894490at2759"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18130">
        <property type="entry name" value="ASADH_C_arch_fung_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02315">
        <property type="entry name" value="ScASADH_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000200">
        <property type="entry name" value="Aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000016">
        <property type="entry name" value="Probable aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051823">
        <property type="entry name" value="ASADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006416">
        <property type="entry name" value="PRK08664.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718:SF1">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000148">
        <property type="entry name" value="ASA_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01103">
        <property type="entry name" value="ASD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="14">
        <location>
            <begin position="5"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="13">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000148-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ45674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="365" mass="39224" checksum="7AC13D5BB2236541" modified="2009-07-28" version="1">MSVKKAGVLGATGSVGQRFILLLSKHPEFEIHALGASSRSAGKKYKDAASWKQTETLPETEQDIVVQECKPEGNFLECDVVFSGLDADVAGDIEKSFVEAGLAVVSNAKNYRREKDVPLVVPIVNPEHIDVVENKVKQAVSKGGKKPGFIICISNCSTAGLVAPLKPLVEKFGPIDALTTTTLQAISGAGFSPGVSGMDILDNIVPYISGEEDKLEWETKKILGGVNAEGTEFVPIPESEMKVSAQCNRVPVIDGHTECISLRFANRPAPSVENVKQCLREYECAASKLGCHSAPKQTIHVLDQPDRPQPRLDRDRDSGYGVSVGRIREDSLLDFKMVVLSHNTIIGAAGAGILIAEILKAKNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJJ7</accession>
    <name>C4YJJ7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_04012</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VAM6/VPS39 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJJ7"/>
    <dbReference type="PaxDb" id="5476-C4YJJ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04012"/>
    <dbReference type="HOGENOM" id="CLU_290702_0_0_1"/>
    <dbReference type="OMA" id="YECESYD"/>
    <dbReference type="OrthoDB" id="5325112at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019453">
        <property type="entry name" value="VPS39/TGFA1_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF49">
        <property type="entry name" value="VAM6_VPS39-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10367">
        <property type="entry name" value="zf-Vps39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CNH" evidence="4">
        <location>
            <begin position="23"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ45681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1033" mass="118576" checksum="168C375AC62DFA18" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJM9</accession>
    <name>C4YJM9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GABA-specific permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04047</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJM9"/>
    <dbReference type="PaxDb" id="5476-C4YJM9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04047"/>
    <dbReference type="HOGENOM" id="CLU_004495_0_3_1"/>
    <dbReference type="OMA" id="RMIWGVV"/>
    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF6">
        <property type="entry name" value="GABA-SPECIFIC PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ45713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="59162" checksum="DDC74C3632F5CDC8" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJU2</accession>
    <name>C4YJU2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_04112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YJU2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04112"/>
    <dbReference type="HOGENOM" id="CLU_706188_0_0_1"/>
    <dbReference type="OMA" id="DVTVGHP"/>
    <dbReference type="OrthoDB" id="4089405at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ45776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="419" mass="47727" checksum="250578697299247D" modified="2009-07-28" version="1">MFFLIQLQPSKTYIQIMLRPIRWNPRMVGIRSFSITRLNFNTNNNTRASPSSSSLFAYIHDYNTLLEKVKSTITSNSSESDILEAMNGIKNLQNNYPIQDQINDTSKLTKQSISIINTIFKNDDDRKFSSKLLHDILILNLPSSLNIKVIKHYYKSNPTDVISKEVALIPLRNAIFNAEFMKAIKLTDLTVGHENYINHMNQILKSGVIKLISTAIIVTLFTKLGVSSLIDAGVISQSWQSIGAINSIILTYLINSSFFISIVKLGRTLINAGGDYLTWQKGTFYTHWFKHADEMLFSSKIIEADRELNQGESNPDIIEELCRRPPDDRDSMRGLKPGVDRDGNKIRLLQLKDDLNKVTFQAYWMTGGDGFEWIEPDQDPADIQWRKHLELYNKPALKQGEFGALGWADDLIQKSTKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJU7</accession>
    <name>C4YJU7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein LST4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_04117</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LST4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YJU7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04117"/>
    <dbReference type="HOGENOM" id="CLU_007917_0_0_1"/>
    <dbReference type="OMA" id="NWLEFKD"/>
    <dbReference type="OrthoDB" id="4063558at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037545">
        <property type="entry name" value="DENN_FNIP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041153">
        <property type="entry name" value="LST4_longin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18639">
        <property type="entry name" value="Longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51836">
        <property type="entry name" value="DENN_FNIP12"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="63"/>
            <end position="967"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
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        <location>
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            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="914"/>
            <end position="937"/>
        </location>
    </feature>
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        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="478"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="741"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="917"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="927"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ45781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1019" mass="114272" checksum="9275D647157D4B3A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJW0</accession>
    <name>C4YJW0_CANAW</name>
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        <recommendedName>
            <fullName evidence="5">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_04130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04130"/>
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    <dbReference type="OMA" id="KDESIAW"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
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        <property type="entry name" value="Pepsin-like_dom"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF75">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="17"/>
        </location>
    </feature>
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        <location>
            <begin position="18"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
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            <end position="350"/>
        </location>
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        <location>
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        </location>
    </feature>
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        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ45794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="363" mass="39104" checksum="E2126654ED1621B0" modified="2009-07-28" version="1">MLFNVLSLICLAIITNAAVVKRDEPKVIRMDVKQGVSELVKRGDATGSSELTQVFYSYADLKIGSNKDPVSLSIDTGSWLTHIFDSNVTCSGCKNTGLYNSSQSSTVVKSGKRGQSFFGAHAYYIGELVSDSIQIGDLNVPEVLFNDVHNTSGFGNGILGLAKPSTKDESIAWVAKNHGLINKAAYSLIIQHLDGSDGSLVIGGYDAAKVNGEINWTSIKNSNIHALLSEVKINGQTIPVNKQYTLDTGGGTGFLPEAAYNQVIANLPEDPKFGTDRSQITCSLLEGKTFTYNLNGVEYEIPLRDFYTPKETNGVCKLGLQKGNAAQLGAWIFRNLLLAVDLEGDLFGLASLKNTTETNITSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK90</accession>
    <name>C4YK90_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_05887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK90"/>
    <dbReference type="PaxDb" id="5476-C4YK90"/>
    <dbReference type="HOGENOM" id="CLU_139870_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ47318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="160" mass="15089" checksum="D91F19A0C85171BB" modified="2009-07-28" version="1">MLELVLGVPFSSFEVPIAGSGGAIGGAGGAGGAGGAGGMFGMRDAFDDELFAIEGGNDPGTDGLAAELELCAELMTFLSSLLAFISDKNGNPPDESGGAVGTFPSFRFCDCSGTVGAGGAGSGGGGGMSFGKGGADVGTGGGPLGNGGGFDEGSCAILLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK98</accession>
    <name>C4YK98_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK98"/>
    <dbReference type="PaxDb" id="5476-C4YK98"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05895"/>
    <dbReference type="HOGENOM" id="CLU_1524941_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="176" mass="19462" checksum="398DBB992BEBF0C0" modified="2009-07-28" version="1">MVRVVDILVVEPAEAENTMDVVGTALREAVARYYIVAVEEHSDMVVGNLLVVVHENDQVLVDSILVEVVYYIVDIAVVVVLVVAVVLVGSVVRVVVVAVVVEEEAVYMIPYIAVVLVEDTFYSDYYDGSDGWVESHDVAVAGRIAEVWVEEANRPCLYKKKIGIGHSTKWINKRVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKB2</accession>
    <name>C4YKB2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_05909</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKB2"/>
    <dbReference type="PaxDb" id="5476-C4YKB2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05909"/>
    <dbReference type="HOGENOM" id="CLU_018300_0_0_1"/>
    <dbReference type="OMA" id="QKKRTDN"/>
    <dbReference type="OrthoDB" id="444809at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029190">
        <property type="entry name" value="Rrp14/SURF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007019">
        <property type="entry name" value="SURF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369:SF0">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04935">
        <property type="entry name" value="SURF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal" evidence="5">
        <location>
            <begin position="158"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="221"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="327"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ47341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="380" mass="43608" checksum="7CD5D9874F759D3F" modified="2009-07-28" version="1">MDNKAKKATSVSLPKKLPKPITQESDEEEEESGDDDDSDEDVEIPDMDVSDDEDDEKQAKEDDDSDIINSNNQLIFDDDGNEVELSSYKKQEVQSTNNNSSDSNNKSKKKQLSDEEQRKRQENLAKLREKLESKINNLKEKRKAIGSKSNGALKSREQILAERQRREELKKQQKRKHDELDNDDEEDSDSGSDSGSDSDSDIDDDKNVLFGNIVFNDGSQVTSDLSKIRNSAEKKKQKGPANKDIKAHLQKLEKKKQKLASMSAEDQEKQREKDKWQRVMAQAEGIKIKDDEKLLKRALKRKEKKKLKSEIEWKERKQVVKDTVAARAKRREENLKARRDNKGKKHQPKLKKFTGTVNKAQLKKKRAGFEGSAKVKSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKC0</accession>
    <name>C4YKC0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKC0"/>
    <dbReference type="PaxDb" id="5476-C4YKC0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05919"/>
    <dbReference type="HOGENOM" id="CLU_933824_0_0_1"/>
    <dbReference type="OMA" id="ANYNAVE"/>
    <dbReference type="OrthoDB" id="4026741at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ47349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="332" mass="37545" checksum="12016E26AB108636" modified="2009-07-28" version="1">MTVRKARTASFFIDIEKNGFLDDDDVAYKQQLEKQLQLHQQRGGNGNGKGRRGESVTLTILVLCILSLTYFIYGYGSTILMNNNLQLDKSILLSSGLGSPEISILTQELINNYDEMNNGGIGLMISDELKEELKQQQQYYSQPKVANVLSSGGDGNAKQENQGYPTTNNNDIDNEDEDYTRKTLMNNNEANNNVNNNYKDDNNNSNNNVDDNDTQNANYNAVETIQANLKEMFAISPMVVISQTNQIDELQTILTKLNINPQPKFINLSKHPNYLNIKHYLKKIYNIDEDDHIPRVFLAGIPIGDSDKIIEMYKENQLISHLREKGQGLINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKE6</accession>
    <name>C4YKE6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protoplast secreted protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_05948</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Flavodoxin-like protein (FLP) that plays a role in cell wall integrity, oxidative stress protection and virulence. FLPs act as NAD(P)H quinone oxidoreductases. Reduces ubiquinone (coenzyme Q), enabling it to serve as an antioxidant in the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WrbA family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKE6"/>
    <dbReference type="SMR" id="C4YKE6"/>
    <dbReference type="PaxDb" id="5476-C4YKE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05948"/>
    <dbReference type="HOGENOM" id="CLU_051402_0_1_1"/>
    <dbReference type="OMA" id="GMFELEQ"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="7">
        <location>
            <begin position="6"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ47375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="201" mass="21728" checksum="1FD5872BC287E2D5" modified="2010-10-05" version="1">MSKPRVAIIIYSLYHHVYTLAESAKIGIEAAGVKPDLFQVPETLTPEILKLVKAPPKPDIPIAEPKILNNYDAFLFGIPTRFGNMPAQWKGFWDGTGGQWARGDLRGKYAGVFVSTGTPGGGQETTVINTLSTLAHHGIVYVPFGYGSPRLADLNEVHGGSPWGAGTFAGADGSREVTELEKSIAQQQGEDFIKTITQFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKH0</accession>
    <name>C4YKH0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_05974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKH0"/>
    <dbReference type="PaxDb" id="5476-C4YKH0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05974"/>
    <dbReference type="HOGENOM" id="CLU_1805919_0_0_1"/>
    <dbReference type="OrthoDB" id="3918848at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ47399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="17034" checksum="6F1C72D1984A9584" modified="2009-07-28" version="1">MFYCGLIFGFFSCARHQTYPIYYLHLDRLTFPNEKKKNNQRNYKNSNNDDNTTTKIINVRKYLKDELRSTIILIKQQTFTKPKHYPGTMLQSINGLRILTLSDIQGNFDIFTKLYNQHQPIDLIIHTGNFGFWDINTIQEYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKR4</accession>
    <name>C4YKR4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Oligomycin resistance ATP-dependent permease YOR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_06071</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YKR4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06071"/>
    <dbReference type="HOGENOM" id="CLU_000604_27_3_1"/>
    <dbReference type="OMA" id="CPQDWPS"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008559">
        <property type="term" value="F:ABC-type xenobiotic transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001750">
        <property type="entry name" value="ATP-binding cassette transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="874"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="917"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="994"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1106"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1130"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="154"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="549"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="882"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1195"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="489"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="773"/>
            <end position="835"/>
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            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="545"/>
            <end position="558"/>
        </location>
    </feature>
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        <location>
            <begin position="780"/>
            <end position="806"/>
        </location>
    </feature>
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        <location>
            <begin position="1322"/>
            <end position="1335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ47493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1488" mass="168187" checksum="C58E8924ECC92625" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKV2</accession>
    <name>C4YKV2_CANAW</name>
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        <recommendedName>
            <fullName evidence="2">RecQ mediated genome instability protein 1 OB-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_06111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="13"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ47531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="168" mass="19164" checksum="1975B83783F0C52A" modified="2009-07-28" version="1">MEELKLDRSTKFLVVSIENISKSRLNQLEEWKQLDNPNKSSVDRLNRKIITEVNLNNDDEDNDESGRPSRANTQDTYKLYLEDVSTKKITQAYENEPLRFLRTENTGTPLPIKLGGRLTVLKGASIYNGVLLLTNKNCEYHGIHADDASYVSILNDGVIKKQIELLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLA4</accession>
    <name>C4YLA4_CANAW</name>
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        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
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            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
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                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
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                <person name="Berriman M."/>
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                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01621"/>
    <dbReference type="HOGENOM" id="CLU_027626_0_0_1"/>
    <dbReference type="OMA" id="HVLQTHQ"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
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        <property type="component" value="Chromosome R"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Asd-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
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        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="126"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="399"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="586"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="14"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
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            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="210"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
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            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
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            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="425"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
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            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="620"/>
            <end position="656"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ43385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="701" mass="74647" checksum="EB3ECAB320C48F77" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLU1</accession>
    <name>C4YLU1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_01810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLU1"/>
    <dbReference type="PaxDb" id="5476-C4YLU1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01810"/>
    <dbReference type="HOGENOM" id="CLU_1315245_0_0_1"/>
    <dbReference type="OrthoDB" id="4026482at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ43572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="189" mass="21553" checksum="6462D93966E8E42D" modified="2010-10-05" version="1">MFGNQITERKGLDLTIPHNNTTKKKSIFKILFITLLIISSGIFLYSSTTTITSYFCYHKQQSTNSISNIPAKIDIDVPLSIEQTNVDINVAVRELIDKKNVESIGLEYIIKREDKKGDNTDDNNKDDNNNDDSKKKSKPIYDQPGMRFVFALFAFVFLNMIAICIHHIYMKITNAANAYKTVDDEISPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLV9</accession>
    <name>C4YLV9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED5</name>
        <name evidence="11" type="ORF">CAWG_01829</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLV9"/>
    <dbReference type="PaxDb" id="5476-C4YLV9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01829"/>
    <dbReference type="HOGENOM" id="CLU_012200_0_0_1"/>
    <dbReference type="OMA" id="MVINICG"/>
    <dbReference type="OrthoDB" id="5322661at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014801">
        <property type="entry name" value="Mediator_Med5_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08689">
        <property type="entry name" value="Med5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="551"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="930"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="930"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="967"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ43590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1038" mass="120509" checksum="BA804452C911185D" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLZ2</accession>
    <name>C4YLZ2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protoplast secreted protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_01865</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Flavodoxin-like protein (FLP) that plays a role in cell wall integrity, oxidative stress protection and virulence. FLPs act as NAD(P)H quinone oxidoreductases. Reduces ubiquinone (coenzyme Q), enabling it to serve as an antioxidant in the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WrbA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLZ2"/>
    <dbReference type="SMR" id="C4YLZ2"/>
    <dbReference type="PaxDb" id="5476-C4YLZ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01865"/>
    <dbReference type="HOGENOM" id="CLU_051402_0_1_1"/>
    <dbReference type="OMA" id="QAGGLWM"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="7">
        <location>
            <begin position="5"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="199" mass="21174" checksum="6FDE77F8382BF092" modified="2010-10-05" version="1">MAPKVAIIIYSLYHHIAQLAEEEKKGIEAAGGVADIYQVPETLSDDVLKLLHAPAKPNYPIATNDTLTGYDAYLFGIPTRFGNYPAQFKAFWDATGGLWAQGALAGKQAGIFVSTSGQGGGQETTAVNALSVLVHHGIIFVPLGYAKAFPLQTNLEEIHGGSPYGAGTFAGVDGSRQPTKLEKEIAFIQGKSFYETVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YME6</accession>
    <name>C4YME6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_02025</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YME6"/>
    <dbReference type="PaxDb" id="5476-C4YME6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02025"/>
    <dbReference type="HOGENOM" id="CLU_001265_12_1_1"/>
    <dbReference type="OMA" id="ASHHESK"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF34">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ43777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="284" mass="32130" checksum="BB2ECBE7660D17B8" modified="2009-07-28" version="1">MENIIKDVEDKKSKLANDGFFAPILKLFLSKKLLYRLLLSTSLFPMQNGAGINAITYYSPAIFASFGITGSKAGLLSTGIFGILKAFAALVWMFCIVDRLGRRTALIYFSFPCSICMWYIGAYIKIAKPGLRVANGDTHQDAGGKAAQAMLYIWTIFYGSSWNGTPWVINSEIFSQEVRTLTQAINSMSNWFWAFIMGRFSGEAVKAIGYKFYFIFATCMAVFPIVIFFLYPETKGVPLEAVDYLFEVPAWRARPYAMAKYQKEYQKQNLSTSIPEEQLEKRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMI7</accession>
    <name>C4YMI7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Quinate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_02069</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMI7"/>
    <dbReference type="PaxDb" id="5476-C4YMI7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02069"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OMA" id="PADHIYM"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF34">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="52"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ43818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="574" mass="64347" checksum="F4DD60AB358DB3DE" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMM3</accession>
    <name>C4YMM3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_02106</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMM3"/>
    <dbReference type="SMR" id="C4YMM3"/>
    <dbReference type="PaxDb" id="5476-C4YMM3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02106"/>
    <dbReference type="HOGENOM" id="CLU_122625_0_0_1"/>
    <dbReference type="OMA" id="IHKRVIH"/>
    <dbReference type="OrthoDB" id="10248551at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000004">
        <property type="entry name" value="30S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_uS10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="6">
        <location>
            <begin position="22"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ43854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="119" mass="13345" checksum="6DE54D3EE2AD43B2" modified="2010-10-05" version="1">MSAPINKEKVEQEAEQQIHKIRITLTSTKVKQLENVSANIIRNAAQYNIVKKGPVRMPTKVLKITTRKTPNGEGSKTWDAYEMRIHKRVIDLQAPASTVKRITQITIEPGVDVEVTIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMN5</accession>
    <name>C4YMN5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Lysophospholipase NTE1</fullName>
            <ecNumber evidence="3 16">3.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Intracellular phospholipase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAWG_02118</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the NTE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="3 16"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMN5"/>
    <dbReference type="PaxDb" id="5476-C4YMN5"/>
    <dbReference type="HOGENOM" id="CLU_000960_1_0_1"/>
    <dbReference type="OMA" id="CTLITCN"/>
    <dbReference type="OrthoDB" id="421051at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000013">
        <property type="entry name" value="Lysophospholipase NTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056556">
        <property type="entry name" value="NTE1_P-loop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF29">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE SWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24179">
        <property type="entry name" value="NTE_Ploop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 15 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 16" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11 15 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="17">
        <location>
            <begin position="131"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="17">
        <location>
            <begin position="239"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="18">
        <location>
            <begin position="623"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="15">
        <location>
            <begin position="627"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="15">
        <location>
            <begin position="654"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="15">
        <location>
            <begin position="774"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="15">
        <location>
            <position position="656"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEQ43866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="928" mass="103838" checksum="44D1E55518B7B66C" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMW9</accession>
    <name>C4YMW9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vitamin B6 transporter TPN1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Transport of pyridoxine protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_02206</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Thiamine-regulated, high affinity import carrier of pyridoxine, pyridoxal and pyridoxamine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMW9"/>
    <dbReference type="PaxDb" id="5476-C4YMW9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02206"/>
    <dbReference type="HOGENOM" id="CLU_026016_2_1_1"/>
    <dbReference type="OMA" id="YERWAWV"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000007">
        <property type="entry name" value="Pyridoxine transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF17">
        <property type="entry name" value="VITAMIN B6 TRANSPORTER TPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ43950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="528" mass="59142" checksum="D53699394F155A7A" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMY4</accession>
    <name>C4YMY4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-ubiquinone oxidoreductase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMY4"/>
    <dbReference type="SMR" id="C4YMY4"/>
    <dbReference type="PaxDb" id="5476-C4YMY4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02221"/>
    <dbReference type="HOGENOM" id="CLU_087364_1_0_1"/>
    <dbReference type="OMA" id="TVPWFNF"/>
    <dbReference type="OrthoDB" id="196140at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053229">
        <property type="entry name" value="NADH-Q_oxidrdct_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024549">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019721">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 21KDA SUBUNIT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10785">
        <property type="entry name" value="NADH-u_ox-rdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12853">
        <property type="entry name" value="NADH_u_ox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit N-terminal" evidence="1">
        <location>
            <begin position="16"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit C-terminal fungi" evidence="2">
        <location>
            <begin position="115"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ43965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="23915" checksum="032585461633630A" modified="2010-10-05" version="1">MSYTATNQPVRAPPLNSDYELIDGDPYFTRVVSYFRFSDYVNWAVITASFPLGMKLWEKIVPSQGKGLKPSVVNPVTLRVSTLLGFFGGFCLNYVKSSQRFLGWRENSREVKLDRFEIKQKLSQGVLPYNEHLSKLDDRNKDISNRNSQYSHALLFVIPWFNTTYHPYHQVDLKKYYINREGEENWGFELKPLDEIYAKYGKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN83</accession>
    <name>C4YN83_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Casein kinase II subunit alpha</fullName>
            <shortName evidence="11">CK II alpha</shortName>
            <ecNumber evidence="11">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_02323</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Phosphorylates YTA7 during S-phase to promote transcription of histones.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="11"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN83"/>
    <dbReference type="PaxDb" id="5476-C4YN83"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02323"/>
    <dbReference type="HOGENOM" id="CLU_000288_70_4_1"/>
    <dbReference type="OMA" id="ECHMIEW"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007535">
        <property type="term" value="P:donor selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060962">
        <property type="term" value="P:regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006356">
        <property type="term" value="P:regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000459">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="43"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ44064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="335" mass="39947" checksum="671A288BEB1E2311" modified="2009-07-28" version="1">MSSHRHNTVQSVSRVYADVLSTKPQSYWDYDDLNIKWNPQENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPVKRKKIKREISILKNLVDGPNIIAMLDVVREPQSKTPGLIFEHINNIDFRSLYPTFTDYDIRFYMYELLKALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEYNVRVASRYFKGPELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEKYNVSLGEEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLTAKEAMKHAYFDPIRVAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNH1</accession>
    <name>C4YNH1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_01431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNH1"/>
    <dbReference type="PaxDb" id="5476-C4YNH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01431"/>
    <dbReference type="HOGENOM" id="CLU_2209689_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="107" mass="11861" checksum="030D21D8990907C7" modified="2010-10-05" version="1">MHSPFNFVSCNILIASFATDSTRTRFISAMTLFPISVSLTNPGINALILIFPLNSFDRLLVNPNKPALDAAYTEVPGIKCSVIDNTEEIFNIVGSDPFWRSIFFTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNI6</accession>
    <name>C4YNI6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cruciform cutting endonuclease 1, mitochondrial</fullName>
            <ecNumber evidence="11">3.1.21.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_01448</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="11"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNI6"/>
    <dbReference type="PaxDb" id="5476-C4YNI6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01448"/>
    <dbReference type="HOGENOM" id="CLU_880308_0_0_1"/>
    <dbReference type="OMA" id="YPQIVIP"/>
    <dbReference type="OrthoDB" id="5552842at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000402">
        <property type="term" value="F:crossed form four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000160">
        <property type="entry name" value="Cruciform cutting endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039197">
        <property type="entry name" value="Mrs1/Cce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015242">
        <property type="entry name" value="Ydc2_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28072">
        <property type="entry name" value="CRUCIFORM CUTTING ENDONUCLEASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28072:SF1">
        <property type="entry name" value="CRUCIFORM CUTTING ENDONUCLEASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09159">
        <property type="entry name" value="Ydc2-catalyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Mitochondrial resolvase Ydc2 catalytic" evidence="13">
        <location>
            <begin position="66"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ43219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="330" mass="38292" checksum="26E09A458720E807" modified="2009-07-28" version="1">MIQKSYLIERLRSCKISTLNDLAILTGSPIISTNKSCRIEGLTAGYYFYLNHYHKFLSTQKQRTTLSIDVGIKNFSYCKSKSSSSSSTLTTSNFPIIITKWDKLNLDTQYGGDNYSSILHKDSILDNKRYLNQLTKSLVNELQPNEYDVVIMEIQRTRSAGNTSTLPTVLLNYTLENLIFGNIYPQIVIPMTSFKMTNFWLHRFITRSTTNTKQLKSNNNNKGIRFELMKLWLNKLFILPKYPQNELTKLDLLKYLKLDKSEKIDDLIDSLLYNLTINCQFQHLAEFHQLMVSNNGDIAQFVHDKNKYHLQLIQPIIDKYELELKPGSID</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-09-21" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNJ0</accession>
    <name>SEC11_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="1">3.4.21.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Signal peptidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SEC11</name>
        <name type="ORF">CAWG_01452</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1 2">Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3 (By similarity). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity). SPC associates with the translocon complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The C-terminal short (CTS) helix is essential for catalytic activity. It may be accommodated as a transmembrane helix in the thinned membrane environment of the complex, similarly to the signal peptide in the complex substrates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S26B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="1"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNJ0"/>
    <dbReference type="SMR" id="C4YNJ0"/>
    <dbReference type="MEROPS" id="S26.010"/>
    <dbReference type="PaxDb" id="5476-C4YNJ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01452"/>
    <dbReference type="HOGENOM" id="CLU_089996_0_1_1"/>
    <dbReference type="OMA" id="ILMNEYP"/>
    <dbReference type="OrthoDB" id="10257561at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0735">Signal-anchor</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000412319" description="Signal peptidase complex catalytic subunit SEC11">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="3">
        <location>
            <begin position="1"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Signal-anchor for type II membrane protein" evidence="3">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="3">
        <location>
            <begin position="31"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal short (CTS) helix" evidence="2">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P15367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P67812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="166" mass="18867" checksum="9620CF24C3827A6D" modified="2010-10-05" version="1">MNIRQQITQFLSLAYVFSSAFMLWKTLSVIANSHSPIVVVLSGSMEPAFQRGDILFLWNRDHQQKVGDIVVYEIDGKSIPIVHRVLREHHNSEKQLLLTKGDNNAVDDLSLYAKKQQYLNQKQDLVGTVKGYLPFIGYVTILISENVYFKYGMLGLLGLSSLFSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNM8</accession>
    <name>C4YNM8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_01491</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNM8"/>
    <dbReference type="SMR" id="C4YNM8"/>
    <dbReference type="PaxDb" id="5476-C4YNM8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01491"/>
    <dbReference type="HOGENOM" id="CLU_057217_0_0_1"/>
    <dbReference type="OMA" id="PHRHQAI"/>
    <dbReference type="OrthoDB" id="201635at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.22.10:FF:000002">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.20.20:FF:000011">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ43261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="242" mass="27235" checksum="6513CB2CB4320E9F" modified="2010-10-05" version="1">MHRALYNSLTKTANACCVSRSVRFVAPQVSVCNPQRLAFRFNSTNASKEAAKEEAPKEEVKSEEEQSSGAESEAQEADPLAELKDKLEKKDKELASMKNHYARAIADFRHLQETTKTEVQKAKDFALQKFAKDLLDSLDNFNLALGHVKEDTLKLNDEVRSLYEGVDMTKTVFEKTLNKYGIEKIDPIDQVFDPNLHEATFQMANPGKEPGTVFHVQQVGYTLNERVLRPAKVGVVKSEDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNN8</accession>
    <name>C4YNN8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-oxoacyl-[acyl-carrier-protein] synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_02819</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 11">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNN8"/>
    <dbReference type="PaxDb" id="5476-C4YNN8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02819"/>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_1"/>
    <dbReference type="OMA" id="QIGHCLG"/>
    <dbReference type="OrthoDB" id="5334845at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000009">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005589">
        <property type="entry name" value="PRK07314.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712:SF336">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="POLYKETIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="12">
        <location>
            <begin position="1"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="10">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ44547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="441" mass="47111" checksum="3479D4A9EF0DA46A" modified="2009-07-28" version="1">MTRVVVTGMGMVSPLGVGLSHNWKQLIANKSGLISHQTLPDYESAGWDKIPSKVIGKVPHGTISEGHWQVGDHIPASEARRMATFSHYALASTHEALKDARLLTEDNNALNMDTNKVGVAVGSGIGSFEDIYNNSIAYNASGYKKVQPLFIPKLLNNMAAGNISIKYQTKGPLHSVSTACATGLQAIGDGFNFLKMGYGQVMICGGTESSIHPLALAGFARARSVVTDSKFNSNPTKASRPFDKSRNGFVLSEGCGILVLETLSHALERGVTPDQIYGEILGYGVSGDAYHITAPHEDGTGAYNAMNQAIERSGIDPEQIDYVNAHATSTVIGDRAENNAMMRLFNPQKTKVSSTKSSIGHLLGAAGAVESIFTLNAIKTGQVPATLNLDNVGQHEGDEQSQFKFDYVANKSITMDVNYAVCNSFGFGGVNSSLCFAKYHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNQ6</accession>
    <name>C4YNQ6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_02838</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNQ6"/>
    <dbReference type="SMR" id="C4YNQ6"/>
    <dbReference type="PaxDb" id="5476-C4YNQ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02838"/>
    <dbReference type="HOGENOM" id="CLU_055193_0_1_1"/>
    <dbReference type="OMA" id="AICVQNV"/>
    <dbReference type="OrthoDB" id="29563at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="8">
        <location>
            <begin position="126"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00063735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ44565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="262" mass="28498" checksum="F7E6A2450DDBE5F5" modified="2010-10-05" version="1">MAPKGKKVAPAPLATKSAKSSESKNPLFESTPKNFGIGQSIQPKRNLSRFVKWPEYVRLQRQKKILSLRLKVPPSIAQFSQTLDKNTAAQAFKLLNKYRPETSAEKKERLTKEAAAIAEGKTAKDVSPKPVVVKYGLNHVVSLIENKKAKLVLIANDVDPIELVVFLPALCKKMGVPYAIVKGKARLGTLVHKKTSAVAALTEVNSADEAELSKLISTINANYIEKYEENRKHWGGGIMGSKANDKIAKKAKAAAAAVSTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNR9</accession>
    <name>C4YNR9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNR9"/>
    <dbReference type="PaxDb" id="5476-C4YNR9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02852"/>
    <dbReference type="HOGENOM" id="CLU_007914_3_1_1"/>
    <dbReference type="OMA" id="CFWPVQY"/>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="501"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="533"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="647" mass="76853" checksum="99AEC8D9A4AC004F" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNT0</accession>
    <name>C4YNT0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_02863</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Endoplasmic reticulum membrane</location>
            <topology evidence="2 10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the OST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNT0"/>
    <dbReference type="PaxDb" id="5476-C4YNT0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02863"/>
    <dbReference type="HOGENOM" id="CLU_031381_1_0_1"/>
    <dbReference type="OMA" id="RYEYARE"/>
    <dbReference type="OrthoDB" id="310030at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007676">
        <property type="entry name" value="Ribophorin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049">
        <property type="entry name" value="RIBOPHORIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04597">
        <property type="entry name" value="Ribophorin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005125142" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1" evidence="10">
        <location>
            <begin position="18"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ44589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="470" mass="54209" checksum="916CABC4F5A27D35" modified="2009-07-28" version="1">MWKFFITLGVIFSICSAQLLDTVSFDSNWENLHYIRNVDLNKGFVKETDLIDIKNINSKPQDEYYFTINDGFDSVNELSVFSAFLNDNLLEVKVDEIVANKVFKLKLPVPIAPNSNVELKINYVYIDTLVPIPTKISMDAVQQLLFKTNKFPYSPYLTKEYTLSLTGMSKGQEMQLHIDVNATEGTPDLKPRVDNQTLKYGPIAEDIQAFTLSPMGLLYDHNRPVTKAVNLNRSIWLPASDVNKVSIEEYYELTHVGAALDSGFSRIDWMKGRYEGTRNHWALSHLELPLLNRDLDGYYYTDKVGVVSSHKVIKNHLLLSPRYPLFGGWNYNFTFGWSEDLSRFLHKLHDTSDEYIIKFPILNSLRDVTYGDVYLEFYLPENAEFQNVSSPIPFESITIDNELSYLDVSKGHTKVTVHYKNLFDDLHKLDVFVKYKYTKINFVYKIVRISGFVFIGLISYYLLGLLDLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPL6</accession>
    <name>C4YPL6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_02417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPL6"/>
    <dbReference type="PaxDb" id="5476-C4YPL6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02417"/>
    <dbReference type="HOGENOM" id="CLU_1895920_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ44155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="134" mass="15000" checksum="75D92E45D86FE42F" modified="2009-07-28" version="1">MELNSILGVVLDTEEDAVEVARCKLLKNECDDFETTSVIERVKEFVNCFVFDLTDEGITKLDKFLNGARERFDNGEPDVAFVFEKVGDGDLELLFNVFEDDFLNALFLIKVGEEQFASSTFVSSCDASGEKSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPQ3</accession>
    <name>C4YPQ3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UvrC family homology region profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YPQ3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02454"/>
    <dbReference type="HOGENOM" id="CLU_000327_0_0_1"/>
    <dbReference type="OMA" id="EGLMAMF"/>
    <dbReference type="OrthoDB" id="360653at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057525">
        <property type="entry name" value="UTP20_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23099">
        <property type="entry name" value="UTP20_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrC family homology region profile" evidence="2">
        <location>
            <begin position="2378"/>
            <end position="2485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2477"/>
            <end position="2499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="2499" mass="285803" checksum="FB0736D2165D6B55" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPS8</accession>
    <name>C4YPS8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_02480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPS8"/>
    <dbReference type="SMR" id="C4YPS8"/>
    <dbReference type="PaxDb" id="5476-C4YPS8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02480"/>
    <dbReference type="HOGENOM" id="CLU_088621_1_2_1"/>
    <dbReference type="OMA" id="AAYHKVQ"/>
    <dbReference type="OrthoDB" id="1724687at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047861">
        <property type="entry name" value="Ribosomal_eS7_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00948">
        <property type="entry name" value="RIBOSOMAL_S7E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ44217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="186" mass="21247" checksum="DE472A1A4D42A5D7" modified="2010-10-05" version="1">MSSKILSENPTELELKVAQAFVDLESQADLKAELRPLQFKSIKEIDVNGGKKALAVFVPPPSLQAYRKVQTRLTRELEKKFPDRHVVFLAERRILPKPARKARKQQKRPRSRTLTAVHDKILEDLVFPTEIIGKRVRYLVGGNKIQKVLLDSKDSTAVDYKLDSFQQLYSKLTGKQVVFEIPGESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPX1</accession>
    <name>C4YPX1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPX1"/>
    <dbReference type="PaxDb" id="5476-C4YPX1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02525"/>
    <dbReference type="HOGENOM" id="CLU_1517681_0_0_1"/>
    <dbReference type="OMA" id="FSEYIFT"/>
    <dbReference type="OrthoDB" id="4021331at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="175" mass="21082" checksum="B447A6995410D373" modified="2009-07-28" version="1">MGNSIDEQTWKNATIDYKNLHKLVENSHSIRSFAFKCQDVIINRSTVDNAYYQSAKRFLLIINLLGFGTEIRRLLIDDLKKIPNFHLNYHSLSPEEQENMVSHVKSIQKWAAHYGINLELAFLLEFSEYIFTKQFIYNSHILYQLLKKEEKIWERRVEFLRLEQQQYEKNRENHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ77</accession>
    <name>C4YQ77_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Allantoate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_02632</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ77"/>
    <dbReference type="PaxDb" id="5476-C4YQ77"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02632"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OMA" id="AYGLYIH"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000245">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF1">
        <property type="entry name" value="ALLANTOATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ44366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="58746" checksum="C69EB16DF053AE5C" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQE3</accession>
    <name>C4YQE3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_02700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQE3"/>
    <dbReference type="PaxDb" id="5476-C4YQE3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02700"/>
    <dbReference type="HOGENOM" id="CLU_030733_0_0_1"/>
    <dbReference type="OMA" id="SWIKINA"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0697">Rotamase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ44432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="358" mass="40742" checksum="A7D45D58B1585588" modified="2009-07-28" version="1">MSYITPTKRIFTPEDLSKWVGSPTYNTVLDFIMELQSSVTGKSNDSSYETSSIIDKLSKLLSKVDNLITLHPAHDSVSRFGKIEFRDFYSDLSSKAEEYISEITATAIQETSAYFIESWGNSTRIDYGSGHELNFICFLLCLKELGQITSADYEGLVLKVFTQYMSIMRKLQKEYWLEPAGSHGVWGLDDYHFLPFLFGAAQLSTHPHMKPKSIHNDELVEMYSTKYMYFECINFINKIKTIPNHQGKLSLRWHSPMLDDISAAKNWDKIREGMVKMYKVEVLGKLPIMQHFMFGSLLKCPEGIPEHTDENGHGENPEDHCGHAHVNTWGDCCGIKIPSGIAASESLKHERKGNIPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQH5</accession>
    <name>C4YQH5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Agmatinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_02733</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQH5"/>
    <dbReference type="PaxDb" id="5476-C4YQH5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02733"/>
    <dbReference type="HOGENOM" id="CLU_039478_1_0_1"/>
    <dbReference type="OMA" id="RNDIRCG"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000001">
        <property type="entry name" value="Agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF28">
        <property type="entry name" value="HYPOTHETICAL ARGINASE FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0745">Spermidine biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ44464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="46398" checksum="111BCA16DC7E1DF8" modified="2009-07-28" version="1">MKLYIFALVACVSSQTIFRSPSLLDQLYGELHGRTNTAPNLQVQAEDPNQMVTQKVLAMRSKLTLPDKDDTSDIAIDQNMFGGILTYAHFNHFNCFISDDFDKHSTTDQQTTKNIDIAIVGAPFDTGTSYRPGARFGPESIRSNSRRLGSAWKSTKKRFNYPVDPYDETTHNYSIIDCGDVAMTPFDNRIALNQLYRGHRSISKHPGNVNQHPKIITLGGDHTITLMAIKNAHEQLRTKIRVFHFDSHIDTWDPRKLGGGITDYMSLNHGTFLHYATELGYIETKGNYHVGIRAPYIDANYDKQHDANCGFHIIQANDIDMIGVQGIIDELAKDPNIPTYISVDIDVLDPAYAPGTGTMEAGGFTTRELLSILDGLKNKVNVIGGDVVEVSPPYDTNSEITSLAATSVVDSLLKLMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQL5</accession>
    <name>C4YQL5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQL5"/>
    <dbReference type="PaxDb" id="5476-C4YQL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02774"/>
    <dbReference type="HOGENOM" id="CLU_009044_0_0_1"/>
    <dbReference type="OMA" id="MLPDQIH"/>
    <dbReference type="OrthoDB" id="66409at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000282">
        <property type="term" value="P:cellular bud site selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052809">
        <property type="entry name" value="Actin_polarity_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012860">
        <property type="entry name" value="Afi1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245:SF1">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07792">
        <property type="entry name" value="Afi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08616">
        <property type="entry name" value="SPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="1">
        <location>
            <begin position="5"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="629" mass="72705" checksum="FC190D15B604780F" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQM0</accession>
    <name>C4YQM0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_02779</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQM0"/>
    <dbReference type="PaxDb" id="5476-C4YQM0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02779"/>
    <dbReference type="HOGENOM" id="CLU_015166_16_3_1"/>
    <dbReference type="OMA" id="PIDCFRQ"/>
    <dbReference type="OrthoDB" id="2139348at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000099">
        <property type="entry name" value="Mitochondrial carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF31">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="16"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="125"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="220"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ44509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="317" mass="35200" checksum="FF74CC8B85F05B5F" modified="2009-07-28" version="1">MDQEITSPNTSHHETLHPLKEITFGATSGMVGKVVEFPLDTIKVRLQSAGSSGGITTLQMIKTTYHNEGIFNGFYKGLKAPMIGACLENAILFSSYNFGSTVITNYLNKNNDKNQYTHETLPFSGKILAGGFAGFMASFVLTPVELVKCQLQVSNLSSDKSHHTYGTIIKSTIRDRGIIGLWKGLNSTIVREVIGTAIWFGTFEYVNDYYKKVKDPWVSNKDVQLLIAGAMAGVTFNFSMFPVDTIKSNIQTHDLFNNNRNSNSMGKHMGFWQTTRSIITKPGGILNLYNGLGITMVRCIPANALIFYTYELLKQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQX1</accession>
    <name>C4YQX1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_04468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQX1"/>
    <dbReference type="PaxDb" id="5476-C4YQX1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04468"/>
    <dbReference type="HOGENOM" id="CLU_444876_0_0_1"/>
    <dbReference type="OMA" id="RNYCYQK"/>
    <dbReference type="OrthoDB" id="449382at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000301">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF1">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="660" mass="74072" checksum="0666A3336F9034E9" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQY2</accession>
    <name>C4YQY2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial inner membrane protease subunit</fullName>
            <ecNumber evidence="11">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_04479</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S26 family. IMP2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="11"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQY2"/>
    <dbReference type="MEROPS" id="S26.012"/>
    <dbReference type="PaxDb" id="5476-C4YQY2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04479"/>
    <dbReference type="HOGENOM" id="CLU_028723_4_1_1"/>
    <dbReference type="OMA" id="WIPVIAW"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.109.10:FF:000005">
        <property type="entry name" value="Mitochondrial inner membrane protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037730">
        <property type="entry name" value="IMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041:SF2">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3 11 14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946831" description="Mitochondrial inner membrane protease subunit" evidence="12">
        <location>
            <begin position="23"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="13">
        <location>
            <begin position="19"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="13">
        <location>
            <begin position="107"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ46135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="162" mass="18178" checksum="95535965BE0F755A" modified="2010-10-05" version="1">MGISRGVKTTLLTLTWFPVLYSFTNHGYQPYQITGSSMTPTFNPGTSTMTKDIVLVQKYNIKKPGSLSRGDIIMFRSPENPEKLLTKRVVGIQGDIIRPKSPPYPKSEVKIPRNHFWVEGDNSFHSIDSNKFGPVSQGLVIGKVVTIIWPPSRFGSELKRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR22</accession>
    <name>C4YR22_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Carbon catabolite-derepressing protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_04520</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Essential for release from glucose repression. It interacts and has functional relationship to the regulatory protein SNF4. Could phosphorylate CAT8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR22"/>
    <dbReference type="SMR" id="C4YR22"/>
    <dbReference type="PaxDb" id="5476-C4YR22"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04520"/>
    <dbReference type="HOGENOM" id="CLU_000288_59_3_1"/>
    <dbReference type="OMA" id="SKTKWHF"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12122">
        <property type="entry name" value="AMPKA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14079">
        <property type="entry name" value="STKc_AMPK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14334">
        <property type="entry name" value="UBA_SNF1_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000544">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000236">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.80:FF:000017">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013896">
        <property type="entry name" value="SNF1_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08587">
        <property type="entry name" value="UBA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="53"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ46175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="618" mass="69763" checksum="17C20B65B433E948" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR23</accession>
    <name>C4YR23_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04522</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR23"/>
    <dbReference type="PaxDb" id="5476-C4YR23"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04522"/>
    <dbReference type="HOGENOM" id="CLU_021544_4_0_1"/>
    <dbReference type="OMA" id="THKFIAH"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF8">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="15"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="397"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="448"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ46176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="487" mass="55120" checksum="AB571E62CE446A06" modified="2009-07-28" version="1">MISIDLLDNSGTSMPAETSIKLHEVIKFISKSKKMTVLTGAGISCNAGIPDFRSSDGLYNMVKAKHPKAVVRGQDLFDISLFRDEMSLSVFCTFMESLYKSSLNAKPTETHKFIKILKDKNKLLRCYTQNIDCIEQHINLKLGINLQEFDNNKFKQVWNQLDVVQLHGNLHKLSCTNCFSQFNWNEEFQTLLANGLNPECSKCMDKYQQRLYSGKRLTGQTIGLLRPDIVLYGEHHPQMEILTQGLNSDLKSRPDCLIIMGTSLKVAGVKSLVKSLSKIIHDKGGKVIYVNKTKLSASSWKNYIDYEVVSDCDEFVRMLKTEIPDLFLTQEQLDSEKLNQVAVKGSNLNKPIVKPEVKVKIEPGIKQEDAIQYSPEREVTIKQEVNIKQEPIVKREVESVSVKEEPIPTPPTTPHKPKQAAKLKRKSPDEISANEVHSRVKRLRPRNDQLSSPASSINGSEEEEEEDEPVAKVLFENARKGITLDQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRN9</accession>
    <name>C4YRN9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_04741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRN9"/>
    <dbReference type="SMR" id="C4YRN9"/>
    <dbReference type="ESTHER" id="canal-q59nx4">
        <property type="family name" value="Steryl_acetyl_hydrolase"/>
    </dbReference>
    <dbReference type="ESTHER" id="canaw-c4yrn9">
        <property type="family name" value="Steryl_acetyl_hydrolase"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YRN9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04741"/>
    <dbReference type="HOGENOM" id="CLU_053543_0_0_1"/>
    <dbReference type="OMA" id="EWCKYAL"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010424">
        <property type="entry name" value="EutQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019436">
        <property type="entry name" value="Say1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169:SF1">
        <property type="entry name" value="ACETATE KINASE EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169">
        <property type="entry name" value="ETHANOLAMINE UTILIZATION PROTEIN EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10340">
        <property type="entry name" value="Say1_Mug180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="47527" checksum="AD4E87E87415A753" modified="2010-10-05" version="1">MLSFKGWKVLLSIPIKLLAVLLKYPFAGGVNKKFKYDLLNSLKLILYRTALHMPVRESALLSIMSNHFIINKLIKNLYPTLTKLPSYGKKYDKQSYWLVKNRDRKPNDPILIFLHGGGYFFETMPCQIESLLSIYHVLDAPKRSSLSILVLDYKLASRGYKIPYQLTQLIETYTNLVKDGNTNMMLMGDSAGGNLALTFLQHLRLDHVNLPYPTSTILISPWVKLAPDEIQNTPGYSYHDNTPVDMIQVDFFRDVEKQNAILGDIEHTELTISPGNCLYRHEDWEDIPSLVEPGHSVFVIVGEHECFRDDVLEWCHFALKSPLTSQRDDSRGVFNPKIHEYIRNGNDFAYVEVVVEPWGVHDSVLYFENTIISKVKKNPKLKVNLLNSHEYFGFIKLVNFLNNVLPGSSQTKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRQ2</accession>
    <name>C4YRQ2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04755</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRQ2"/>
    <dbReference type="PaxDb" id="5476-C4YRQ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04755"/>
    <dbReference type="HOGENOM" id="CLU_068315_3_0_1"/>
    <dbReference type="OMA" id="WNMKDEW"/>
    <dbReference type="OrthoDB" id="341924at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000064">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ46405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="231" mass="25981" checksum="CE671D59AD7569F8" modified="2009-07-28" version="1">MSVSAPEDIRPSTSNGDQSNRDTNTPTTSTSASTTAPPPPPPPPQQQQQQPSSSITTTDNNNNNQTSQQSQEKKEKIIPRDVRLLHLIFATHAVHNYQDHVPLQLMDFAHRYTKSVLKDALVYNDHSKPINANTNLNSNTNATVNTDDIRLAIAARSNYQFKPVPPKELLLELAQERNSRPLPPVIPRWGLNLPPEKYCLTAKDWDSIYDEPDEDNNNQSSQQKNKKLKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRR3</accession>
    <name>C4YRR3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRR3"/>
    <dbReference type="ESTHER" id="canaw-c4yrr3">
        <property type="family name" value="Steryl_acetyl_hydrolase"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YRR3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04769"/>
    <dbReference type="HOGENOM" id="CLU_053543_0_0_1"/>
    <dbReference type="OMA" id="WIHESPN"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000754">
        <property type="entry name" value="Protein of uncharacterized function (DUF2424)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010424">
        <property type="entry name" value="EutQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019436">
        <property type="entry name" value="Say1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169:SF1">
        <property type="entry name" value="ACETATE KINASE EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169">
        <property type="entry name" value="ETHANOLAMINE UTILIZATION PROTEIN EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10340">
        <property type="entry name" value="Say1_Mug180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="57377" checksum="4D25B9EF481C257D" modified="2009-07-28" version="1">MNIYIYIYIYIKKSILISITISVPFLFHFSFYKKLIFFILFHFTSLHFISLPIMLTFKGLLLILLLPSRLLSFIIKYPFIKGIPGKYQHNFSKSLFIKLCRLIQLLPVSDKGTLNFISTNFLLNKIMKLYHTRYFLGELNNFGKKFDDQSYWIHESPNRNRNKNKSDDPIIVYLHGGSYYFDNSLNQMESLIGIYQLLQNTTTITTTTTTNDDSTSVERKKNLSILVLDYKLASKGYKMPYQLNQLISTYKNLIYQGNTNLILMGDSAGGNLAITFLQHLRLTNNNNNNNNNSPANLPYPKSLILISPWCKIVPEISDYTKGHSMYDNNQYDIIEWKAVKKLIDNTSPLIRDDLSPQNLIISPGNLPYNIDDWIDIDTLQKSNYSTFVIMGEYETLRDDILNWCQYAVNSTLSSPIKHTQGIFDKNIHQFVSTKNDGAYVKCIIEPKGIHDASMIFENDILKEFQKHPKMNLQTINKDKYFGIYQIVEFLNEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRU9</accession>
    <name>C4YRU9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRU9"/>
    <dbReference type="SMR" id="C4YRU9"/>
    <dbReference type="PaxDb" id="5476-C4YRU9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04806"/>
    <dbReference type="HOGENOM" id="CLU_059951_0_0_1"/>
    <dbReference type="OMA" id="QVASVNC"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03002">
        <property type="entry name" value="PDI_a_MPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944437" description="Thioredoxin domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="12"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="299" mass="34633" checksum="67CB18F5B0A83FE0" modified="2010-10-05" version="1">MIFNYLLALFQILVLASARAQADEYASDPNIFELTPSNFDKVVHKSNYTTLVKFYAPWCGYCQKLQPVYHKLGKYINKDAKYSINIASVNCDKDYNKQLCSQYQVRGFPTLMVFRPPKYEKGKQVKLQKHASEVYQGERTVKSITKFLTSRLKNYVKKFHNIRSDGIAEWLAEDIPSVLLISNANSVSPLLKSIAIDFLDRVNVGMISKFNDESHKFVIGDKEIEVPATSKSSLFYFNKEKGELVAYTKSDKLNDKIKITEWIIEQTQQQPIEGPLSKKEKKYYYKYRTGKKKIEHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRW0</accession>
    <name>C4YRW0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRW0"/>
    <dbReference type="PaxDb" id="5476-C4YRW0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04817"/>
    <dbReference type="HOGENOM" id="CLU_074138_2_0_1"/>
    <dbReference type="OMA" id="IEMRSET"/>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="3"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="273" mass="30138" checksum="A767D46463B73FD0" modified="2009-07-28" version="1">MSSVIASNIPSDVSPVKVREFFSFCGKIIDLKPLDDNGKVKKYEVVFASPKAVSTALLLSDAELENTFIKVEEVPEITEGETGLAPEQGGGAAAAATTTTTTEKDIKEEPVLTGDKTYDEVDQEEKPKYAIFAQLLADGYVISDQVIAKGIEFDKKNGVSSRFNEFITGLDKKYVHSQDPNSKVNQQLQKAQASYEKSGIDQKLRKYFEDAAKSPLGLKIHEYYKSFAKDVTDVHQEAVRLANIKKRELEEKKQAESGSTTTETKDTSIPQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSA5</accession>
    <name>C4YSA5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSA5"/>
    <dbReference type="PaxDb" id="5476-C4YSA5"/>
    <dbReference type="HOGENOM" id="CLU_042614_0_0_1"/>
    <dbReference type="OrthoDB" id="4023732at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030446">
        <property type="term" value="C:hyphal cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030445">
        <property type="term" value="C:yeast-form cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043710">
        <property type="term" value="P:cell adhesion involved in multi-species biofilm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043709">
        <property type="term" value="P:cell adhesion involved in single-species biofilm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033504">
        <property type="entry name" value="ALS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793:SF2">
        <property type="entry name" value="AGGLUTININ-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793">
        <property type="entry name" value="ALPHA-AGGLUTININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="324" mass="32014" checksum="DC8F50C41BDD0836" modified="2009-07-28" version="1">MSKPVDIPSSDVVTSTNDNSLTSLTGSENGETSVAISTTFCDDENGCQTSIPQGSVVRTTATTTATTTTIIGDNNGSGKSKSGELSSTGSVTTNTATPDVPSTKVPSNPGAPGTGVPPPLAPSTETQTTNNVPGSPNIPATGTTDIIRESTTVSHTVTGNGNTGVPMNPNPALTTSTSLTGATNSATNPSHETGVNTGSGGSTNIVTPPSSATATVVIPGTDNGATTKGQDTAGGNSNGFTATTNTQGGNNEPGNQPGTNTTGEPVGTTGTQSVESTSQPTTLSQQTTSSLISTPLASTFDGSGSIVQHSGWLYVLLTAISIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSB7</accession>
    <name>C4YSB7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_04980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSB7"/>
    <dbReference type="SMR" id="C4YSB7"/>
    <dbReference type="PaxDb" id="5476-C4YSB7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04980"/>
    <dbReference type="HOGENOM" id="CLU_022670_9_0_1"/>
    <dbReference type="OMA" id="MQVVPYS"/>
    <dbReference type="OrthoDB" id="1937934at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="158"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="241"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="440"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ46620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="529" mass="58406" checksum="C2205A180E588F97" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSE8</accession>
    <name>C4YSE8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSE8"/>
    <dbReference type="PaxDb" id="5476-C4YSE8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05013"/>
    <dbReference type="HOGENOM" id="CLU_101043_0_0_1"/>
    <dbReference type="OMA" id="FANFIQC"/>
    <dbReference type="OrthoDB" id="4011213at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="240" mass="28156" checksum="5993CC82894A5647" modified="2009-07-28" version="1">MSKNWDINTYKPREFSDSFYHHCCFLLFYIDPFIAWLSFDFFVSITTTMLFPIILILSIFANFIQCLFKSSSEPFILAAYDPDYSPYDDNKIMNQNIQRFGYNKTKVILSKHINTTNIYLEGRILDNSSYQIDATLKGMFIRVDKFTHRLKLCPNGKTSKYFSIEKDMLFYKNDTIWSVCYDEFEDVSYIYHGSIDDNKKYCCPDNGKEIILRTLGKYDASGALPDYTKHPHKKNSNVLG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-11-30" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSJ2</accession>
    <name>ASA1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>ASTRA-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ASA1</name>
        <name type="ORF">CAWG_05058</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ASTRA complex involved in chromatin remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ASTRA chromatin remodeling machinery complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat ASA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSJ2"/>
    <dbReference type="SMR" id="C4YSJ2"/>
    <dbReference type="PaxDb" id="5476-C4YSJ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05058"/>
    <dbReference type="HOGENOM" id="CLU_045414_0_0_1"/>
    <dbReference type="OMA" id="LVCCNTQ"/>
    <dbReference type="OrthoDB" id="7668193at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0156">Chromatin regulator</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000402205" description="ASTRA-associated protein 1">
        <location>
            <begin position="1"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="10"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="53"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4">
        <location>
            <begin position="263"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5">
        <location>
            <begin position="342"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="377" mass="42551" checksum="58A321EBAF24F267" modified="2009-07-28" version="1">MLSTKFTLRSHKSSVTYIYQDPRTPFNLFTADSSGLIINWDLTIRRPKKSWQAHTDTILTISTIHNHLLTHSRDNTIKIWDESYSCILEIPCNALNFSNICVINDLLITPASINSNNLDVYKIDKDWQITRLIFDFDVYKLVNKGEIIEEIGSSGTSRNDFGIIMQMKIIHTNTTTTTSENNSDYIIYVGFESGDIVGLQLILPRARILSTTGNTNDKTLINQSAKFILQYHNSTHVPNPVICLSNLDSVLVSGSTTNKVIIHSDPIEIMKMDHSGIQAIVNFKNDRLIFGYWNGYIQYGDISINQSLPKLGNTEQEKSKLTKKLTFMTILNESNQETLQSPTGKSKYSVLLKSKRNLVSPLLLAGYEDGSILAYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSK8</accession>
    <name>C4YSK8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_05076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSK8"/>
    <dbReference type="PaxDb" id="5476-C4YSK8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05076"/>
    <dbReference type="HOGENOM" id="CLU_1713010_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="153" mass="18077" checksum="34A41D9B774A767F" modified="2009-07-28" version="1">MFLEQDAYLSQFTVRPFNYVCEMIRLQGHPTPYPAFQPPPLPPFLQRDARVCQNCNTVILDAFNEMKRYSCCARCLMNDALSHGYSLALSNTVKILALKQVLEGNSLEDNQFVLKFLFDRFLEQYKGKKFDYEIELLKYKTREDDNYYEIKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSN6</accession>
    <name>C4YSN6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_05104</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSN6"/>
    <dbReference type="PaxDb" id="5476-C4YSN6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05104"/>
    <dbReference type="HOGENOM" id="CLU_041954_1_0_1"/>
    <dbReference type="OMA" id="KWQALET"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="115"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="320"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ46739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="350" mass="38661" checksum="D7F753D3B3A1BBBE" modified="2009-07-28" version="1">MPQLPTSSDREYRYNYNQDSSFSTLRNVLTTKLAAVSDIIQQARTWYLEQSTIKQILLGGALVVIGVISVLMVIFHIHIIRFLIYLSDEWHNLKYGSLIIFALVFMVGFPPLIGFSALSFLTGMIYGCPQGWPLIASASVLGSTCSFIVYRYVLHNQAVKLMNHNDTFRAFAEILGEGNSLFLLILIRLCPLPYSLSNGALAAIPELPLLTYFLATLITSPKILIHLFVGSKLKQIGDDKSSGGTKIVDIISIVITGTAATLAAYLIYAKMQQKLASYHSRGIAADDVMVFGNFEDDLELGSNEIELNSADFDADNFIIEDDDNEDDPNQQGNGNNVKKDNGVQTSEEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT62</accession>
    <name>C4YT62_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT62"/>
    <dbReference type="PaxDb" id="5476-C4YT62"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05761"/>
    <dbReference type="HOGENOM" id="CLU_1906463_0_0_1"/>
    <dbReference type="OMA" id="CERCPEC"/>
    <dbReference type="OrthoDB" id="10340547at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946886" evidence="1">
        <location>
            <begin position="19"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="133" mass="15144" checksum="A73CA38F1228A420" modified="2009-07-28" version="1">MMFARIFMIILMLGGVWCERCPECAEPARILRNECGVPTKTDLGGYFDCVCGLNGTFFDMYESCLKHCKALDYITFNTNNSTLREFYCQEAQKASTTEVTDTFPDAELQRYVTRNGGTHKKPSFVLTILMCMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTE6</accession>
    <name>C4YTE6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sorting nexin MVP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_05435</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTE6"/>
    <dbReference type="PaxDb" id="5476-C4YTE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05435"/>
    <dbReference type="HOGENOM" id="CLU_399000_0_0_1"/>
    <dbReference type="OMA" id="CCHEELT"/>
    <dbReference type="OrthoDB" id="10064318at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07597">
        <property type="entry name" value="BAR_SNX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028662">
        <property type="entry name" value="SNX8/Mvp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045734">
        <property type="entry name" value="Snx8_BAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554:SF1">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19566">
        <property type="entry name" value="Snx8_BAR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="10">
        <location>
            <begin position="312"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Sorting nexin 8/Mvp1 BAR" evidence="11">
        <location>
            <begin position="514"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="203"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ46887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="690" mass="78753" checksum="797681CDA9242427" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTJ5</accession>
    <name>C4YTJ5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTJ5"/>
    <dbReference type="PaxDb" id="5476-C4YTJ5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05488"/>
    <dbReference type="HOGENOM" id="CLU_681516_0_0_1"/>
    <dbReference type="OMA" id="CRVEIRD"/>
    <dbReference type="OrthoDB" id="4019982at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="485" mass="56749" checksum="981B7F3ACD3924CD" modified="2009-07-28" version="1">MKYQQIPKSIRLLFDIYKQLSNKQNSVYHPQVGKYLSQTNDLNLIYQQWQILTNNRKKGDSIKNITERQFYSPSISFGDYELSSTKKLFIKPTKNHFSFITGLPLEDPIFSSKSHDKNRHGQFINNIENNLLSYYSPFTQYPQNSKSQLAYKYYLRKFDESIPIMIILKKKYQMFSIFSMNHWDKIYFDMKRQTRRQNILTNVDDLTIPSRRNMMKLSQRQFEFTSINRIDLFKLALGSYNYFKSLSNPTTIFSNKFNLNKNLQIASWNGNEFTSQSYNNNNNNNNDDDELIKMIDKNCRVEIRDQSTGDIISPDDSKLLEYVNKEKSYVKQLDQDEVMDYSQQIPYQLNFDKYYMLNILNFDSGDTRLSSFSRILNTATRTTTTTTTGGGGDKNSSNSDISPSDLEIVGVRLSLDNPQVNRMINEMSDIKLNNKDDDVFAYEDILKLVHTPKRNVLRSLMDILAVKGIIKVRQSADKRGLYLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTL3</accession>
    <name>C4YTL3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nucleoside permease that transports adenosine and guanosine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NUP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTL3"/>
    <dbReference type="PaxDb" id="5476-C4YTL3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05508"/>
    <dbReference type="HOGENOM" id="CLU_031475_0_1_1"/>
    <dbReference type="OMA" id="GRFVMTN"/>
    <dbReference type="OrthoDB" id="2331083at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009486">
        <property type="entry name" value="Pur_nuclsid_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643:SF1">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06516">
        <property type="entry name" value="NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013171">
        <property type="entry name" value="Pur_nuclsid_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005668209" evidence="2">
        <location>
            <begin position="18"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR013171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="378" mass="42396" checksum="1E1A17B768F2B3C6" modified="2009-07-28" version="1">MITLLIFIFAFLGNVLCYPQAIISHQISPKVMIVSMFQPEEEAWTSKVDFQHNITVPGLHPLYPNVHCTSNFDICQFTTGEGEINAASSVAFLISNSKFDFSNTYWLLAGIGGGDPAKVTTGSVTFAKYAIQVGLQYQIDSRELTNTNHKEGWTSGYFSYGTKHPQDYPDSVYGTEVFEVNEKLRDRAMELSRKNEKLLKLGDDDNVSLRKLYSSPANKSPTILACDVLTSDNYFTGHVLNDYFSSYSQLITNSSANYCSSAQEENATLESFIRVAKNGLIDYERIVIMRTISNFVAKPKDLSIDPIEFFNEYPKGGIQHALDNLYIGGWPFVEDVVNNWDSLYKDGQSFKAENYLGDILNTLDGQGKDFGKDSYHIS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-31" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTQ0</accession>
    <name>PRM10_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>Pheromone-regulated membrane protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">CAWG_05545</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Membrane</location>
            <topology>Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTQ0"/>
    <dbReference type="TCDB" id="2.A.79.1.10">
        <property type="family name" value="the threonine/serine exporter (thre) family"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YTQ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05545"/>
    <dbReference type="HOGENOM" id="CLU_007078_1_0_1"/>
    <dbReference type="OMA" id="FVYFPGT"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000409251" description="Pheromone-regulated membrane protein 10">
        <location>
            <begin position="1"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="782"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="809"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="835"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="860"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="903"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="938"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="963"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1075"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="592"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="1105" mass="120738" checksum="816C0448D6A8670D" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTT7</accession>
    <name>C4YTT7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Metal resistance protein YCF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_05582</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cooperates for the ATP-dependent vacuolar transport of bilirubin and glutathione conjugates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YTT7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05582"/>
    <dbReference type="HOGENOM" id="CLU_000604_27_6_1"/>
    <dbReference type="OMA" id="CFETGMR"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042592">
        <property type="term" value="P:homeostatic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000020">
        <property type="entry name" value="ABC metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000450">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000001">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="592"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="989"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1030"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1116"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1220"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="17">
        <location>
            <begin position="327"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="653"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="17">
        <location>
            <begin position="990"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="1310"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="883"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="938"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="941"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ47028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1576" mass="177178" checksum="A59737F9FDEA2961" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCQ6</accession>
    <name>C4YCQ6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_00290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCQ6"/>
    <dbReference type="PaxDb" id="5476-C4YCQ6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00290"/>
    <dbReference type="HOGENOM" id="CLU_021458_6_1_1"/>
    <dbReference type="OMA" id="EDTIPMW"/>
    <dbReference type="OrthoDB" id="10030083at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000017">
        <property type="entry name" value="Diacylglycerol pyrophosphate phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="99"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ42092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="261" mass="29510" checksum="4590198BB7A62D51" modified="2010-10-05" version="1">MLQIYFTSSKFRKFIPDWIVVILLVIIFFQVTEVAQPFARQFYINDPTISHPFATQEQVTDNQLYLYSVLIPSLIISLISLYLGESNFEKLHNLQVSCLGLWLSVCVTSVLTDVLKCWISNPRPDFLERCGPQKGTPENKLVGIEVCTSPLGPMYLSDGLKSTPSGHSSMAFSGLLYLSLWLVGQFKLIQKRKSIGYVLIAGLPILVAAYIALSRTQDYRHHFFDIGFGSAIGIVFAVIFYYKYFNSLSDESCNVPIDYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD98</accession>
    <name>C4YD98_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD98"/>
    <dbReference type="PaxDb" id="5476-C4YD98"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00488"/>
    <dbReference type="HOGENOM" id="CLU_1992301_0_0_1"/>
    <dbReference type="OMA" id="HINPRRK"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="125" mass="15162" checksum="7D45202E34DE76C0" modified="2010-10-05" version="1">MLSTRLSLRIKFLPTYFLLLFCNISQYSKLLLFQAFKKRNIIVLKVCKKFMLIYFFVWFFKVIIREGGEPTIRLSTFKRFMDCLDDIKAHYQIHINPRRKFSCIYLPLVPLFLVKGLFLMKNEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDA6</accession>
    <name>C4YDA6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation machinery-associated protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_00496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMA16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDA6"/>
    <dbReference type="SMR" id="C4YDA6"/>
    <dbReference type="PaxDb" id="5476-C4YDA6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00496"/>
    <dbReference type="HOGENOM" id="CLU_106785_0_0_1"/>
    <dbReference type="OMA" id="WAYIATI"/>
    <dbReference type="OrthoDB" id="270284at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.170">
        <property type="entry name" value="Translation machinery-associated protein 16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021346">
        <property type="entry name" value="Tma16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038356">
        <property type="entry name" value="Tma16_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349:SF2">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11176">
        <property type="entry name" value="Tma16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ42292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="23335" checksum="AB93F083B8D9AF6D" modified="2010-10-05" version="1">MPLAHNLNKVTKNISKSTGSLHIKGRKFKQLNRATLRDKKLQQRKSQSLERKSNELSIVFFIQSLLQEKNTANDGGDEDEEEGENFKEFSNKKQFTLDEMKQIIEKFIHQNDDELQRLQSERRKGRPPTNRQTILEEKLKYDLEIYRTGFKIPDLTDQLTVERIKEWNGTTGATTTMKFIRVSKDMTELPTTTNEIEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDG4</accession>
    <name>C4YDG4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_00558</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDG4"/>
    <dbReference type="PaxDb" id="5476-C4YDG4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00558"/>
    <dbReference type="HOGENOM" id="CLU_390837_0_0_1"/>
    <dbReference type="OMA" id="WIPYDKA"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000775">
        <property type="entry name" value="Cell-cycle-regulation transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF3">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="4">
        <location>
            <begin position="55"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="310"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="433"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ42350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="726" mass="82153" checksum="24428967B165A9F3" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDN5</accession>
    <name>C4YDN5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 11">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_00632</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 11"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDN5"/>
    <dbReference type="PaxDb" id="5476-C4YDN5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00632"/>
    <dbReference type="HOGENOM" id="CLU_010467_0_0_1"/>
    <dbReference type="OMA" id="CCPELIG"/>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000009">
        <property type="entry name" value="Glutamate--cysteine ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="487"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ42421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="685" mass="78694" checksum="09263992EBDE48FD" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDR3</accession>
    <name>C4YDR3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_00660</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDR3"/>
    <dbReference type="PaxDb" id="5476-C4YDR3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00660"/>
    <dbReference type="HOGENOM" id="CLU_003824_1_0_1"/>
    <dbReference type="OMA" id="PVLMHRY"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017104">
        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003164">
        <property type="entry name" value="Clathrin_a-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02296">
        <property type="entry name" value="Alpha_adaptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="3 7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="10">
        <location>
            <begin position="790"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="751"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="756"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="56"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ42449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1042" mass="117808" checksum="2C4D4657C73ED8BC" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDV4</accession>
    <name>C4YDV4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDV4"/>
    <dbReference type="PaxDb" id="5476-C4YDV4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00702"/>
    <dbReference type="HOGENOM" id="CLU_1219553_0_0_1"/>
    <dbReference type="OrthoDB" id="4081922at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="227" mass="26641" checksum="4708B0B5D34617D0" modified="2009-07-28" version="1">MFEYDHTGKLIPTYNNVAEKLREMELNGDKFLERAHEQTNSKKRGKKSKHKNKKPLASKKDKGNKSKPLKEEDVLSSKDDNDEEVSTITPISKSNHLEIIREIEIPHDSSRNQPTTIPIDYFGLIPSISNECCLICQYQAIYGTEPRQMKKWYDQRVHAEEKRRRDFKKKLQNAKSKVLKRQKDWRQKDPDTAQKQKQTKYVIRGKDSDSRTQPNNETLANRIDEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDV7</accession>
    <name>C4YDV7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription initiation factor TFIID subunit 1 histone acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_00705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YDV7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00705"/>
    <dbReference type="HOGENOM" id="CLU_467676_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 1 histone acetyltransferase" evidence="4">
        <location>
            <begin position="491"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="201"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="414"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ42493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="583" mass="67453" checksum="27FB878C77CB296D" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDY0</accession>
    <name>C4YDY0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pcl7p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00729"/>
    <dbReference type="HOGENOM" id="CLU_017199_0_0_1"/>
    <dbReference type="OMA" id="PTTNVHN"/>
    <dbReference type="OrthoDB" id="1060854at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF94">
        <property type="entry name" value="PHO85 CYCLIN-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="549"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="681" mass="76065" checksum="29BB3732E7DCEA62" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEP6</accession>
    <name>C4YEP6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cell wall mannoprotein PIR1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_01004</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PIR protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEP6"/>
    <dbReference type="PaxDb" id="5476-C4YEP6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01004"/>
    <dbReference type="HOGENOM" id="CLU_061202_1_0_1"/>
    <dbReference type="OMA" id="HERHECD"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054508">
        <property type="entry name" value="PIR1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051153">
        <property type="entry name" value="Yeast_CWMannoprotein_PIR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254:SF1">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22799">
        <property type="entry name" value="PIR1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall mannoprotein PIR1-like C-terminal" evidence="8">
        <location>
            <begin position="234"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="328"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ42782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="356" mass="41087" checksum="7E7DE43B17D73DD9" modified="2009-07-28" version="1">MLSLTKPPTATATATTHTETKTINTAQISLQIFSFFFFSFHHYLIKYQINQLTNSIIMRFSIATLSLAAFTVVSAGYISRGEGLTRGEKHERHECDFDSFEWKFGLAVKELKHHGDKNWDRDVDLDLVYESDDGQLYHGCKEVYKASKCRNCYETFEFSDNESSDDEGSGSDCEDDVCRERRKKVHRNYNVGGYGSERRQSDCESDCERSERCNYPFCELYEDNCDLLLTLCDGVLHDDRHATGEIVANHQFQFDKPPQKDALHKKGFSIVYTHGNYYLALDNKIKFWHCKVDDNGLYKIYDKSIGEQCCEIELIILKSDKKAEFEFTDRESDSEGSDCDDDCKKNKKHGKKHSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YES3</accession>
    <name>C4YES3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein ILM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YES3"/>
    <dbReference type="PaxDb" id="5476-C4YES3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01031"/>
    <dbReference type="HOGENOM" id="CLU_117796_1_0_1"/>
    <dbReference type="OMA" id="CDLMWQF"/>
    <dbReference type="OrthoDB" id="5299849at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018815">
        <property type="entry name" value="Incr_loss_mito_DNA_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28029">
        <property type="entry name" value="PROTEIN ILM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28029:SF1">
        <property type="entry name" value="PROTEIN ILM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10311">
        <property type="entry name" value="Ilm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15533" checksum="4F2C0AAB36D19793" modified="2009-07-28" version="1">MTGFIVLLGQAMQVPLIRLTPTNPLLGMASIVFISLALSDLIPLLAENWSYFENLVPIRLSGYFCLAAYIYFVPTSIVSNSLVITYVLFEIWGNFLIYNNLRDEKYYRMKKFVEENSEAIRTAHDEQVRVVELDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF70</accession>
    <name>C4YF70_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_01182</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PER33/POM33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF70"/>
    <dbReference type="PaxDb" id="5476-C4YF70"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01182"/>
    <dbReference type="HOGENOM" id="CLU_065417_3_0_1"/>
    <dbReference type="OMA" id="NVQYLIM"/>
    <dbReference type="OrthoDB" id="5581259at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051645">
        <property type="entry name" value="PER33/POM33_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005344">
        <property type="entry name" value="TMEM33/Pom33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03661">
        <property type="entry name" value="TMEM33_Pom33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ42956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="333" mass="38162" checksum="48A81C9F81D615EA" modified="2009-07-28" version="1">MAIFISRKSNGKAKKKYNLLSIKSNQILFAFRQCHLFHHPCFPYYSLHTSMPPTQPTPTNSANLRYRTPLQQLVTLAKTQQFYWFLGHVFAVLFFILSTLTGFWNRHSSLKYYRFSLLSIILTYLIVIRQIHFKSTFKLSSINIRLLRDENVQYLLLAVIFYVSSFIIGQTGSSLYSFAIFAVFHVLTYFQNHLLSVFIGDIATQSRISSMISNFTSKFNQPALIAASNAEIVLLVVSGFQLIPSALLLLFRRNIVEVSVQVLVFVAIVVFNKLRFDSNQYTKVVVEQMDLKVNQTLAQINSPQLSQLYQNARAGALKYLSLIKLPKESGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFM7</accession>
    <name>C4YFM7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFM7"/>
    <dbReference type="SMR" id="C4YFM7"/>
    <dbReference type="PaxDb" id="5476-C4YFM7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01345"/>
    <dbReference type="HOGENOM" id="CLU_2108678_0_0_1"/>
    <dbReference type="OMA" id="EHVVIIE"/>
    <dbReference type="OrthoDB" id="4020293at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="66"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="115" mass="13277" checksum="BC2F401C9F0A5D2A" modified="2010-10-05" version="1">MIKYIISNNINNILIRLLPQLSELTYINSTSPEVLLKIEGLDHSLINYEFSNNLQQMVGVINRDTIVIENLSKYNLDEFSLVQLFKKLGDIKQCYIVDNRKIGFIELLCDEVVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFQ4</accession>
    <name>C4YFQ4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Chromatin structure-remodeling complex protein RSC8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_00030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFQ4"/>
    <dbReference type="PaxDb" id="5476-C4YFQ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00030"/>
    <dbReference type="HOGENOM" id="CLU_004447_3_2_1"/>
    <dbReference type="OMA" id="PSFSKWF"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02336">
        <property type="entry name" value="ZZ_RSC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041984">
        <property type="entry name" value="Rsc8/Ssr1/Ssr2_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802:SF150">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX PROTEIN RSC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802">
        <property type="entry name" value="SWI/SNF COMPLEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SWIRM" evidence="8">
        <location>
            <begin position="63"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="305"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="9">
        <location>
            <begin position="308"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="515"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="419"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ41843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="64303" checksum="7AA2E7A3FEEF5925" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFV5</accession>
    <name>C4YFV5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_00081</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFV5"/>
    <dbReference type="PaxDb" id="5476-C4YFV5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00081"/>
    <dbReference type="HOGENOM" id="CLU_142427_2_1_1"/>
    <dbReference type="OMA" id="RLWSTFY"/>
    <dbReference type="OrthoDB" id="5566853at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013958">
        <property type="entry name" value="DASH_Dad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28025">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28025:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08649">
        <property type="entry name" value="DASH_Dad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ41894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="98" mass="11370" checksum="C83C65C3804DAAAE" modified="2009-07-28" version="1">MSNSSSNPSKNEYFIKQRDLLIQEISNNLSIVQTNLETLNRSLHESKQIGKEFDDVARLWSTFYDGMNGMNHQTRENTRDENNKISSSDTEDENNNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG32</accession>
    <name>C4YG32_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Formin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_00148</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the formin homology family. BNI1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YG32"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00148"/>
    <dbReference type="HOGENOM" id="CLU_001313_1_0_1"/>
    <dbReference type="OMA" id="TPSIKMK"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000142">
        <property type="term" value="C:cellular bud neck contractile ring"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001411">
        <property type="term" value="C:hyphal tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000920">
        <property type="term" value="P:septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.2220:FF:000006">
        <property type="entry name" value="Cytokinesis protein sepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.30.50:FF:000001">
        <property type="entry name" value="Cytokinesis sepA protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000898">
        <property type="entry name" value="Formin BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="10">
        <location>
            <begin position="111"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="11">
        <location>
            <begin position="1130"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="9">
        <location>
            <begin position="1565"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1543"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1603"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="578"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="895"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="12"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="765"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="780"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="992"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1029"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1050"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1078"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1101"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1695"/>
            <end position="1713"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ41956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1734" mass="196839" checksum="90A7066E02DDA16B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG83</accession>
    <name>C4YG83_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome chaperone 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_00204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Psm_Assembly_Chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018854">
        <property type="entry name" value="Psome_chaperone_3/4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10448">
        <property type="entry name" value="POC3_POC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ42007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="18501" checksum="5F714062564EF7A6" modified="2010-10-05" version="1">MTTKLIQDPTGFSKSFETTYPNDTSSSSTNEFFFHIINYSDKQILNISINGLMDTTFELPVSTKSAITYASALEIPMDQFDDEHEQEEVREREVIPEPILLIGDHSNMKLSIVATQISKLISNNCPKPTILSIGSKWFGKGDEVDDNDFEKLMFILANVKTLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGF6</accession>
    <name>C4YGF6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CipC-like antibiotic response protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGF6"/>
    <dbReference type="SMR" id="C4YGF6"/>
    <dbReference type="PaxDb" id="5476-C4YGF6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03132"/>
    <dbReference type="HOGENOM" id="CLU_1815522_0_0_1"/>
    <dbReference type="OMA" id="MAWGWEQ"/>
    <dbReference type="OrthoDB" id="9895617at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022234">
        <property type="entry name" value="DUF3759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450:SF1">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12585">
        <property type="entry name" value="DUF3759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="15832" checksum="07274A24AD3C1DD9" modified="2009-07-28" version="1">MSEILKANHRKVYGNVSNSSSSSSISMSPSGSATNKRSTRSAGDNRSKLSHDMVAGAASFEATRLFEDRHRRNGKPVSHAFARKTLIALAASEVDKLFEVKELTHLDKDQIKSEAIKAIEKEYETHYGGQRHWSPNFKPISW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGQ1</accession>
    <name>C4YGQ1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGQ1"/>
    <dbReference type="PaxDb" id="5476-C4YGQ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03232"/>
    <dbReference type="HOGENOM" id="CLU_694441_0_0_1"/>
    <dbReference type="OMA" id="HNAHIVA"/>
    <dbReference type="OrthoDB" id="3981234at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="401" mass="42583" checksum="AD31BEF3D7F819C0" modified="2009-07-28" version="1">MSENITSTTSATATAANTNTNTNTNTNTPTSTTTTTTTTVTHSKSNYYNPSLIHHSIYNNNNNNNGTAGSTGPIKTIAAATSTSAAPTTNTDSGKTSVSSISTSNSIFSEAPEVNSHHYYSHPPHQHFPFMTNNNHHHHSNVNVGGIPTSGYPFPQPNASPTTTIAGTITSHSNGTPESQQQQPLVAPPPQSQPTVSASLPQFQNQIVSGTGASTNPPLNPRISAKFTNNDIQILRQLLLAGEKHKWKQITKELNSSTNHNAHIVAAISAAAIKSRSLVNNYDSNNNINDNTPTTNLHHSFGYHHLQQQQHSLEQKSLGHRVGNGTTGSSSSASSGSISGNSPSTIPAKNVSPTFVVKQYQQLLGLPNNALYFGTLGSSLPYVVAENGWDDIGPEAVNYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGU1</accession>
    <name>C4YGU1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SIS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGU1"/>
    <dbReference type="PaxDb" id="5476-C4YGU1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03275"/>
    <dbReference type="HOGENOM" id="CLU_040681_2_0_1"/>
    <dbReference type="OMA" id="FKWELIK"/>
    <dbReference type="OrthoDB" id="1872003at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05014">
        <property type="entry name" value="SIS_Kpsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035474">
        <property type="entry name" value="SIS_Kpsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38418">
        <property type="entry name" value="SUGAR ISOMERASE, KPSF/GUTQ (AFU_ORTHOLOGUE AFUA_6G08860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38418:SF2">
        <property type="entry name" value="SUGAR ISOMERASE, KPSF_GUTQ (AFU_ORTHOLOGUE AFUA_6G08860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="52"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="392" mass="43157" checksum="2DD667AA7F798042" modified="2009-07-28" version="1">MSNPISQYLASVSLNSVQSTLKYETDAVTNLFNQYQQDEFAINNIIQSITIMYNTIVANNGKIVITGVGKSYKLGLKLVATLNSLSIQSSSLHPTEALHGDLGLIDQNRDCLIMVTSSGNTPELIQLLPHLSSNLPILLLTCSKNSKLSQYNQINSLILAELLSCHKEEIIHGIPAPTVSFTLSMMLADAVILALSELIETDSLKRKKLFGLKHPGGSIGANLAQEFNQNNTNRSGDNTITTTTTTNTNTNNSSSITVQAPIIPPSNLMSATTSTTTRLSSNSSSMLSLKEMELESYSSVDDTDERGQAQKSCKEITYQDLLKLQELSLLQWIVRYDSIRLIETDNKGGSSNSSSSSSNNYVSCDFIQSLYKKHYDGLNWDKFKWELIKKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH36</accession>
    <name>C4YH36_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_03377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YH36"/>
    <dbReference type="SMR" id="C4YH36"/>
    <dbReference type="PaxDb" id="5476-C4YH36"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03377"/>
    <dbReference type="HOGENOM" id="CLU_169796_0_0_1"/>
    <dbReference type="OMA" id="KWPIANT"/>
    <dbReference type="OrthoDB" id="4023341at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ45068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="111" mass="13443" checksum="B5132D44F71ABC21" modified="2010-10-05" version="1">MRNTLIKRSIITPKRFHTIKLPHQINQDPVKPRLSQFSHALYNTLMISLSTFFLFNIVYNNLQYQEIEQELKLKSTTLENQIQTIVDEKDKQLKQEQESSNKRWIHKLKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH93</accession>
    <name>C4YH93_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_03438</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YH93"/>
    <dbReference type="SMR" id="C4YH93"/>
    <dbReference type="PaxDb" id="5476-C4YH93"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03438"/>
    <dbReference type="HOGENOM" id="CLU_036856_0_1_1"/>
    <dbReference type="OMA" id="DHRVGFK"/>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000004">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="5">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00067174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ45125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="394" mass="44809" checksum="DA5A3A66B43BCAE4" modified="2010-10-05" version="1">MHLLLRIPPRFGLSSWGSIRPILPRRIPNFPRFNSSTGSSLTIPTLSPSLLQRAQTIQQEHKELSEKLADKYIPDLQVKFDNYTNILSMFDKLETLTQEYIELTEITDDPDLYKEAQEELKSIVIPQIEKLVSELRVKLRPPVKYADKGCIIELRPGVGGNEASLFTGDLLNMYMNFASEMNWKYKIISEGKNSSGFINEAILSIDTLGSYDIMRHESGVHRVQRIPETETKGRVHTSTAAVVVLPKLSEGNESSLKDDERVFAPGEVRIDTMRAGGKGGQHVNTTDSAVRLLHIPTGMIVIQQDERSQPLNKAKAFAILRSRLAQKEQEEEMLKQKKLRTDQVSSTDRSDKIKTYNYKENRVTDHRINYSMHDLEGVLEGRKLGQLIDVYRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHH4</accession>
    <name>C4YHH4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_03520</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHH4"/>
    <dbReference type="SMR" id="C4YHH4"/>
    <dbReference type="PaxDb" id="5476-C4YHH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03520"/>
    <dbReference type="HOGENOM" id="CLU_008891_9_1_1"/>
    <dbReference type="OMA" id="HPAANMI"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03338">
        <property type="entry name" value="TCP1_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000010">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012717">
        <property type="entry name" value="Chap_CCT_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
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    </dbReference>
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        <property type="entry name" value="TCOMPLEXTCP1"/>
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        <property type="entry name" value="GroEL apical domain-like"/>
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    </dbReference>
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        <property type="entry name" value="GroEL equatorial domain-like"/>
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    </dbReference>
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        <property type="entry name" value="GroEL-intermediate domain like"/>
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    </dbReference>
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        <property type="entry name" value="TCP1_1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ45206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="544" mass="59286" checksum="D8209BFDC3849210" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHL3</accession>
    <name>C4YHL3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_03561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="95"/>
        </location>
    </feature>
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        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ45245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="152" mass="18016" checksum="F38682CBB6F3075A" modified="2009-07-28" version="1">MYTIIERYYTPIDRFINKLRRKGFWLYTGLITVSFVYVIFSISNLPSLPPPPPSSSPKSKRKKDKMVSKSTKERIENEDEVELGPSDPVVPLEQTHSNDHIINSWSKRQLYQFLFEEKIYPDVDEELNTIKKQVIEIYEFKKQHGTLDKKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHL9</accession>
    <name>C4YHL9_CANAW</name>
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        <recommendedName>
            <fullName evidence="5">Bfr1p</fullName>
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    </gene>
    <organism evidence="3 4">
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        <name type="common">Yeast</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OMA" id="AHWKEDQ"/>
    <dbReference type="OrthoDB" id="2195113at2759"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027:SF2">
        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="NUCLEAR SEGREGATION PROTEIN BFR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
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            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="164"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ45251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="53498" checksum="12E024107AD6DC17" modified="2009-07-28" version="1">MSSVKSATTSTSAAPRRREIKRPDDKAIKEEIEKLKDEIKKLDLTNNEINAQIAKAQIDQKVMDKRNKLQTELKSLIAKQSQGKNERQLINDQIKAIDASMKKRIAEIQQQTSKNNFKNVAEIDSRINYLDGLIDAGNLKLADERRFVKEMSSLRKLRKDFGSIEKTQELIDQDKAKIAELKKKLSATHNKEVQAQFETIQKELDAINESNKTIISKRDELRDKRTEIKKQKDAKYEQIRKIRSDFDEKFASFKKQLAEEKKRRDEEYKQRLLEEKQQKKKEQAEKELAEASIPAFTEEINSIHTLLSYFDPSYVKPTKKTETNGALPINNNIRKVEFPEDFVVIKKEQEEFFAGTKGKKGKQHQKKSTKHKNFTVAPEVVVALSDLTIAFPTKEEEVPETIKTLKETLTALEEKQEEQTKINIERAKARIAKLEAEEDKEEEFETTAEEKDQKVEEQSTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHV0</accession>
    <name>C4YHV0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_03653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHV0"/>
    <dbReference type="PaxDb" id="5476-C4YHV0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03653"/>
    <dbReference type="HOGENOM" id="CLU_037761_0_0_1"/>
    <dbReference type="OMA" id="CCITIGN"/>
    <dbReference type="OrthoDB" id="4095311at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ45332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="628" mass="72701" checksum="81D33CF4613FBD82" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHY2</accession>
    <name>C4YHY2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_03686</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHY2"/>
    <dbReference type="PaxDb" id="5476-C4YHY2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03686"/>
    <dbReference type="HOGENOM" id="CLU_065390_0_0_1"/>
    <dbReference type="OMA" id="GEYLKMI"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000215">
        <property type="entry name" value="Ptc8p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13672">
        <property type="entry name" value="PP2C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="142"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ45364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="419" mass="46960" checksum="01BFA791C101D63D" modified="2009-07-28" version="1">MLSSARKILLQSPKQLTTLIRPTNSFIIKRRNYSGSSIFKGARNYFLGFRNNSEDSQINNNNNNNNNNSSMHYDSVDESIPYVKYPLFTKEQLKKIATDKFKLQVGHASFGYHSDSIVPSINSLSDLTDPTRLNSLLPRRRPQGSPSDTLSIKAGDDTMLVSPSVIAVADGVSGWESDGITSSSGIWSRSMVETFSRLMTEYKLNHFPHYLNQRDIQEILDDSYLHTSHLMDLQKLNGSSTLILGMLNGDLLSIVSIGDSKIFIIRDGEIVLTNEEQTKAGLCPEQIGTHTLDHLPSDIAWIKSFKLMEGDYILMCSDGISDNLYEWEILNYLNEWINTKRNNNNNVKNIASKLLIKAKEVAFDDYAYTPYNEKVNSLNNTNGGSNGTNHSQGGKVDDMSVIIAKVELNKKDNTKLVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI91</accession>
    <name>C4YI91_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DOCKER domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_04163</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YI91"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04163"/>
    <dbReference type="HOGENOM" id="CLU_238900_0_0_1"/>
    <dbReference type="OMA" id="KPIFFDP"/>
    <dbReference type="OrthoDB" id="18896at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11684">
        <property type="entry name" value="DHR2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057500">
        <property type="entry name" value="C2_DCK1_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25338">
        <property type="entry name" value="C2_DCK_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOCKER" evidence="3">
        <location>
            <begin position="1389"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1831"/>
            <end position="1914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1831"/>
            <end position="1840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1844"/>
            <end position="1863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1888"/>
            <end position="1914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ45826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1914" mass="216033" checksum="576C416DB887ADD8" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIA2</accession>
    <name>C4YIA2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_04174</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIA2"/>
    <dbReference type="PaxDb" id="5476-C4YIA2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04174"/>
    <dbReference type="HOGENOM" id="CLU_015166_10_1_1"/>
    <dbReference type="OMA" id="YKMSVPK"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="26"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="126"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="231"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ45837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="326" mass="36410" checksum="3A6154134B348D80" modified="2009-07-28" version="1">MEEYKLQPIAKESNHLLSDIKNFIKIDSNASFIAGGIAGAVSRTVVSPFERAKILLQLQGPGSQQAYQGMFPTILKMYREEGWKGLFRGNLLNCIRIFPYSAVQFATFEKCKDIMLHYNPRDTQQLNGYERLIAGSVGGIVSVAVTYPLDLVRARITVQTASLSKLNKGKMIRAPKVMETLKDVYKNEGGILGLYRGIIPTTLGVAPYVAINFALYEKLREMMDSSPRDFSNPVWKLSAGAVSSFIGGVLIYPLDLLRKRYQVASMAGGELGFQYRSVAHALHSIFTTEGFFGAYKGLTANLYKIVPSMAVSWLCYDTLKDWINRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIA6</accession>
    <name>C4YIA6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription initiation factor TFIID subunit 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_04178</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIA6"/>
    <dbReference type="PaxDb" id="5476-C4YIA6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04178"/>
    <dbReference type="HOGENOM" id="CLU_078004_0_0_1"/>
    <dbReference type="OMA" id="GEFDMTI"/>
    <dbReference type="OrthoDB" id="1741717at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16905">
        <property type="entry name" value="YEATS_Taf14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.220:FF:000005">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016665">
        <property type="entry name" value="Sas5/TAF14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23195">
        <property type="entry name" value="YEATS DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016551">
        <property type="entry name" value="SAS5/TFIID_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YEATS" evidence="4">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="117"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ45841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="236" mass="25946" checksum="250CBB805374C43F" modified="2010-10-05" version="1">MRKWSVQISMLDSQGKEHPAKILDKVTYTLHPTFANPIRTLKQQPFRVEEQGWGEFDIPIAVHILGIPGKAGERKIQHDLNFLQEKYVNDHVISIPVSPTRNPALNKLLAETGSLPFEESGAGASSANSGSIGTKRKLESSNGATATAATSADNKSKKSKGAMKGNIDLEKLSQGLTKLSEDDLIVVVQMVTDNRTNEMNIKNDVDNGEFTMDLYTLPDSLLKSLWDYVKKHTGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIP9</accession>
    <name>C4YIP9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Replication factor C subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_04325</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the activator 1 large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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</entry>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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                <person name="Sakthikumar S."/>
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                <person name="Grabherr M."/>
                <person name="Forche A."/>
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                <person name="Logue M.E."/>
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</entry>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="21 22">WO-1</strain>
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            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)</text>
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            <begin position="2282"/>
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            <begin position="2230"/>
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            <begin position="2295"/>
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            <begin position="2305"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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            <dbReference type="ARBA" id="ARBA00012009"/>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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            <dbReference type="ARBA" id="ARBA00022753"/>
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            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00075294"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EEQ45638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="2615" mass="294919" checksum="304C69A86A72F91F" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJR0</accession>
    <name>C4YJR0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Amine oxidase</fullName>
            <ecNumber evidence="15">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAWG_04079</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a primary methyl amine + O2 + H2O = an aldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16153"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:228804"/>
            <dbReference type="EC" id="1.4.3.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="15">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="14">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="14 15">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="15"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJR0"/>
    <dbReference type="PaxDb" id="5476-C4YJR0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04079"/>
    <dbReference type="HOGENOM" id="CLU_011500_3_2_1"/>
    <dbReference type="OMA" id="VHVGFNY"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000019">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000014">
        <property type="entry name" value="Peroxisomal primary amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049947">
        <property type="entry name" value="Cu_Am_Ox_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF86">
        <property type="entry name" value="COPPER AMINE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01165">
        <property type="entry name" value="COPPER_AMINE_OXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 15" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="18">
        <location>
            <begin position="23"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="19">
        <location>
            <begin position="114"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="17">
        <location>
            <begin position="248"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="13">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="14">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEQ45744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="709" mass="79814" checksum="BC5D04CB106B9AA5" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJU4</accession>
    <name>C4YJU4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Cytochrome c oxidase subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Cytochrome c oxidase polypeptide VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_04114</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJU4"/>
    <dbReference type="PaxDb" id="5476-C4YJU4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04114"/>
    <dbReference type="HOGENOM" id="CLU_099086_1_1_1"/>
    <dbReference type="OMA" id="MEKWPAD"/>
    <dbReference type="OrthoDB" id="5778907at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.40:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0349">Heme</keyword>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ45778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="150" mass="17405" checksum="4E4ED4EEAB94719C" modified="2009-07-28" version="1">MFSATVRSALRSRLSAQVPRASNTLRAVTISKPLTSQIRSYSSNHHEETFEEFTARFEKEFENAYDLFEVQRILNNCFAYDLVPAPAVIEKALQACRRVNDYPTAVRTFEALKFKVETPEQYQAYLEELKDIRKELGIDLKEDLYAEDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK15</accession>
    <name>C4YK15_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Replication factor A protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_05809</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EEQ47244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="SMR" id="C4YK15"/>
    <dbReference type="PaxDb" id="5476-C4YK15"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05809"/>
    <dbReference type="HOGENOM" id="CLU_051033_0_0_1"/>
    <dbReference type="OMA" id="SFGNKRY"/>
    <dbReference type="OrthoDB" id="25571at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04478">
        <property type="entry name" value="RPA2_DBD_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014646">
        <property type="entry name" value="Rfa2/RPA32"/>
    </dbReference>
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        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036949">
        <property type="entry name" value="RPA32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB" evidence="6">
        <location>
            <begin position="73"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A C-terminal" evidence="7">
        <location>
            <begin position="174"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ47244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="29376" checksum="99A1424014CEC7B3" modified="2010-10-05" version="1">MSDFEYDNNNTGAFGNISQGGFNTEHAGSSQRQTTTQVRQSLTPVTIKQINDATQPVPDGEFKVNNVELNMISFVGVVRNVENTNASIAVTIEDGTGSIDVRKWVDETISSAEEDFEKYNEMKGKYVYVGGSLKQFNNRKTVQNASISLITDSNQIVYHHLSAIEHHLKAQGITAADAASAGAGQATNSTASAGSGLFMDNPTSLSKDTGSLTDQVIAVLKEASRTMPDGVPVDYVAEKLSITKEESQFQLLKLNDEGKAYAGYDDNSYLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK20</accession>
    <name>C4YK20_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial 54S ribosomal protein MNP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_05815</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK20"/>
    <dbReference type="SMR" id="C4YK20"/>
    <dbReference type="PaxDb" id="5476-C4YK20"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05815"/>
    <dbReference type="HOGENOM" id="CLU_086499_0_1_1"/>
    <dbReference type="OMA" id="LEDKWGV"/>
    <dbReference type="OrthoDB" id="250175at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="50S ribosomal protein L7/L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_bL12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_bL12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_bL12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="Ribosomal protein L7/12, oligomerisation (N-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL12 oligomerization" evidence="5">
        <location>
            <begin position="43"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein bL12 C-terminal" evidence="4">
        <location>
            <begin position="107"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ47249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="18707" checksum="751ACACE8A988B62" modified="2010-10-05" version="1">MSAIIRQAIRPALRSVSSKRIAVTALRYNSTAAEPAKAPVDAKITTIVDQISTLTLLETSQLINELKERLNISDISLPVGGAQAAPVAQAAPAEEEVKEEVEEKTIFSIKLESFDAKSKPKIIKEVKGMLGLSLVESKKFVESAPKVLKENVAKEDAEKIKATLEGLGAKVSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK49</accession>
    <name>C4YK49_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ferrochelatase</fullName>
            <ecNumber evidence="12">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_05845</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ferrochelatase family.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="12"/>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK49"/>
    <dbReference type="SMR" id="C4YK49"/>
    <dbReference type="PaxDb" id="5476-C4YK49"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05845"/>
    <dbReference type="HOGENOM" id="CLU_018884_1_0_1"/>
    <dbReference type="OMA" id="DPYHCEC"/>
    <dbReference type="OrthoDB" id="1323at2759"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1400:FF:000003">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ47278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="386" mass="44067" checksum="C87E52080B53EC65" modified="2010-10-05" version="1">MMFRSTFKPTCIARRGFFRFNSSNSSKPPTGIVFMNMGGPSKVEETYDFLLRLFSDGDLIPFGRFQNILAKFIAKRRTPKIEEHYREIGGGSPIRKWSEYQCKKVCEILDKTSPETAPHKPYVAFRYANPLTEETLNDMKKDGVTKAVAFSQYPQFSYSTSGSSMNELYRQTLIHDPERTIDWSFIDRWPQQPGLVKAFANNIKEKLAEFPPQDRDDIVILFSAHSLPMEIVNLGDSYPAEVAATVYKIMEELKFSNPYRLVWQSQVGPKPWLGGQTSKIIDKLEKRDDIKGIVLVPVAFTSDHIETLHELDIEILEDATNPHKIKRAESLNGNETFIEGLADLVKSHLKSGEKYSKQLELDCILGSERAQGTFKHPNEIFGNRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK74</accession>
    <name>C4YK74_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein RHO2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_05871</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK74"/>
    <dbReference type="PaxDb" id="5476-C4YK74"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05871"/>
    <dbReference type="HOGENOM" id="CLU_041217_21_2_1"/>
    <dbReference type="OMA" id="NDNVMRR"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000573">
        <property type="entry name" value="RHO family GTPase Rho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ47303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="186" mass="20781" checksum="A90205A0FD3F52B0" modified="2009-07-28" version="1">MSESVRRKLVIVGDGACGKTSLLYVFTLGEFPTEYHPTVFENYVTDCRIDGKPVQLALWDTAGQEEYERLRPLSYNNSHVILIAFSLDTPDSLDNARSKVVEVKKYCPNTPYLLCGLKKDLRTDKSDRVNFVQFDMGQAMADVIGAKKYLESSALTGEGVDDIFEYAVRTSLLKNDKANTGCCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK86</accession>
    <name>C4YK86_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_05883</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="3"/>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK86"/>
    <dbReference type="PaxDb" id="5476-C4YK86"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05883"/>
    <dbReference type="HOGENOM" id="CLU_033546_0_1_1"/>
    <dbReference type="OMA" id="MMLVGDI"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000014">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000056">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF36">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="13">
        <location>
            <begin position="5"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="308"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ47315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="446" mass="48571" checksum="0DC8B88912A92711" modified="2009-07-28" version="1">MRDLIVLGGSSHPNLTKSICRSLTLEQGLVDSRKFSNGEISIEVKNSVREKDVFIIQSGCGHVNDNFLELLITIAACKTASAKRVTAVSPLFPYSRQPDIPYLANATGAPSISTKKEEYTFESAPATPNPLSKSSSEKSFLSQASSSIVSENKAATTGVNNISSGNRIKSPVPKKYTPKLIHTNASATNFLPQVDAYGKTESGYKQWISPNGTLIANLLTTAGADRVITMDLHDPQFQGFFNIPVDNLYSKPILKHYILNFIPNYKDCVIVSPDSGGAKRATAIADSLGCPFALIHKERRAKLPKNPPSTSMSNSHSHNHYNSQHKPTMVATTMLVGDVASKVCVLVDDLVDTSYTITRAAKLLKDQGAEYVYALVTHGIFSGDAINRIQQSAIDKLVVTNSTPQSEHVEILGDRMEVLDVSRVFAESIRRINNGESVSMLFDHGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKQ9</accession>
    <name>C4YKQ9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TUG ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_06065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKQ9"/>
    <dbReference type="PaxDb" id="5476-C4YKQ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06065"/>
    <dbReference type="HOGENOM" id="CLU_521749_0_0_1"/>
    <dbReference type="OMA" id="ERIMLIW"/>
    <dbReference type="OrthoDB" id="440781at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021569">
        <property type="entry name" value="TUG-UBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467:SF1">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11470">
        <property type="entry name" value="TUG-UBL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TUG ubiquitin-like" evidence="3">
        <location>
            <begin position="79"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="537"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="269"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="537"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ47488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="582" mass="67428" checksum="58D93787B70B6A31" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKR0</accession>
    <name>C4YKR0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_06066</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the bZIP family. GCN4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKR0"/>
    <dbReference type="PaxDb" id="5476-C4YKR0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06066"/>
    <dbReference type="HOGENOM" id="CLU_068501_0_0_1"/>
    <dbReference type="OMA" id="IDHTPMF"/>
    <dbReference type="OrthoDB" id="5419235at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12193">
        <property type="entry name" value="bZIP_GCN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12192">
        <property type="entry name" value="GCN4_cent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001491">
        <property type="entry name" value="Cross-pathway control protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050946">
        <property type="entry name" value="AP-1_TF_bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462">
        <property type="entry name" value="JUN TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462:SF35">
        <property type="entry name" value="TRANSCRIPTION FACTOR JRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="11">
        <location>
            <begin position="268"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="273"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ47489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="322" mass="35287" checksum="B88B530E6622B0EB" modified="2009-07-28" version="1">MPATTPIIYEDSLFESQDLFASPVKQPHQKVDTVATKNEIGLELNLGLPEMQKASETVSTPFQIHSSVLESVFSTNLDGVNDIDHTPMFDELDLIMDGAKVNSSEDWVALFGDDNDDGVAIAGATSKEPMLSLNEDNENNDDDADDDDDDESLVPREDTIEALLLEPSPNRTISAATSASTSSLNSPESTIATTVTAGGEVVVASKKQFQLVTPNPSSTLPTPLLDSKNSKKRVKVDHLGCVTYSKKHRSQPLQPIVVDDIKDAAALKRAKNTEAARRSRARKMERMSQLEDKVENLINEKQALQDQVERLQELLRVNGIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKT5</accession>
    <name>C4YKT5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_06093</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKT5"/>
    <dbReference type="PaxDb" id="5476-C4YKT5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06093"/>
    <dbReference type="HOGENOM" id="CLU_031900_2_1_1"/>
    <dbReference type="OMA" id="HEIDAKC"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17016">
        <property type="entry name" value="ING_Pho23p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000016">
        <property type="entry name" value="Inhibitor of growth protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="432"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="202"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="329"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="363"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="445"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ47514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="483" mass="51944" checksum="1B029115F78350C2" modified="2009-07-28" version="1">MRTKQQQQQQQQSNSSSGVANNQKSYGYTTKTKSNSSVTNGGNVGATLTESRIITNINELLPGLNDISDAFEALPIDLIRYFTLLKEIDAKCINTIPQINHLINQYITNLHQDKNVTTTTTTTTTTNDDNTIDLNKKLETRRLNLIKNKINEVIPCLEEKMHVTSVASDLLKKHMYRINQDYKLILLNNEIPQSIRIGPLNHPAMINDTHTTSSSSTTSTGNGTGGGGGTNNNHGGNNSVQSQRSESRREALAARKANKEDDRENNTATGGSGRKKKKEQNNNNNSTASGADGNNGSNGKKRNRDDKSNNAGSGNDLKKKKKPNNNDQLDNRRRGEDENGKGDGETSFNSGNAKNDPHGKLKTTTTGNLVGGSSTTTTVSSSSTTSSSATTTTTSSTTTTKNSGSTGASTATATGASGAKGSSSSSSGNNEPTYCYCNQVSFGEMVGCDGDDCKREWFHLPCIGFKNPPKGKWYCDDCLKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKT6</accession>
    <name>C4YKT6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_06094</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKT6"/>
    <dbReference type="PaxDb" id="5476-C4YKT6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06094"/>
    <dbReference type="HOGENOM" id="CLU_033908_0_0_1"/>
    <dbReference type="OMA" id="CPMSFRR"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF31">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR_REPRESSOR MOT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="51"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="128"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="231"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="405"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="509"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="232"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="514"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ47515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="583" mass="65356" checksum="3891941B139389EF" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKU7</accession>
    <name>C4YKU7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="6">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_06106</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="6"/>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKU7"/>
    <dbReference type="SMR" id="C4YKU7"/>
    <dbReference type="PaxDb" id="5476-C4YKU7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06106"/>
    <dbReference type="HOGENOM" id="CLU_000022_3_6_1"/>
    <dbReference type="OMA" id="AIKASWP"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000004">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="10">
        <location>
            <begin position="40"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="8">
        <location>
            <begin position="104"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="9">
        <location>
            <begin position="553"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ47526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="675" mass="75100" checksum="32CD1F462F789B90" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKX0</accession>
    <name>C4YKX0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_06129</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKX0"/>
    <dbReference type="PaxDb" id="5476-C4YKX0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06129"/>
    <dbReference type="HOGENOM" id="CLU_024798_0_0_1"/>
    <dbReference type="OMA" id="NICISNF"/>
    <dbReference type="OrthoDB" id="2193813at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08049">
        <property type="entry name" value="TAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019473">
        <property type="entry name" value="TFIID_su8_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10406">
        <property type="entry name" value="TAF8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="8">
        <location>
            <begin position="4"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor TFIID subunit 8 C-terminal" evidence="9">
        <location>
            <begin position="128"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="302"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="302"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="319"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ47549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="403" mass="47421" checksum="66FDAA79D637EBE3" modified="2009-07-28" version="1">MDTVLERIVGTLLETRNYTFTEQFLDQLTELTLQFVNELSADLSKYTRIQRRQQPSLSDIKLLLKLKHISTNELIREIELSKKFTYRKQLASLLDQLVEEPIKEQSRPFFDQSSITELVPRLNVKPDYIPSYLPDLPPDYTYQSTPEYMETLTDLKKLRMKLVEESRMTENSLYKLIEYDDIEWRQKFEQELVELSPDSSANETTEVPIPTTNGKSEDFKFDIVEYARMRKRLLIKRDRDLENRRKAREENMFMKAEMYYSPYSTLKPTAEVKQYFSDALSDGFKSVIVSVRNAEKLKEQNIKRQMEENARREQELQKQNESISFSFPTINQLESESESDNDFEQEVKDNIELNFDGSDNERESRNLVVVQNSDEKALQQDPPPSKFAEDVSDMSSDDMDTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKX2</accession>
    <name>C4YKX2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_06131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKX2"/>
    <dbReference type="PaxDb" id="5476-C4YKX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06131"/>
    <dbReference type="HOGENOM" id="CLU_897154_0_0_1"/>
    <dbReference type="OMA" id="YNYPYVH"/>
    <dbReference type="OrthoDB" id="21266at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070692">
        <property type="term" value="C:CTDK-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032786">
        <property type="term" value="P:positive regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042326">
        <property type="entry name" value="Ctk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024637">
        <property type="entry name" value="Ctk3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024638">
        <property type="entry name" value="Ctk3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291:SF1">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12243">
        <property type="entry name" value="CTK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12350">
        <property type="entry name" value="CTK3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="1">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="290" mass="34112" checksum="41D96D678DAB3CB9" modified="2009-07-28" version="1">MDSFDAANQLLQMLRSLSPQLQHLSKAVYFALKNSDKEDYLLPTILDVINDKQLPTSIKANILQFVDLLINESLSSDKYKQAYVQGLKDNLPLIITQVTDNKSNLYSTYLSLFNISQHFKMDCHGFVSQFDSNMLTDKDIDLIKRNEEFTKSDINDDEPLVRAWKILLQCKHECQFERAKLLEHSEYIDDIVDEDSLFSIREKSNPSTTLLSKRQILVRMEDDREAHKRSKENFWVVNRDKEKGNHITEDEFVSHYWNKFQPLNDQENKEFLNSLQELNVIVENSYKDKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL16</accession>
    <name>C4YL16_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_01530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL16"/>
    <dbReference type="PaxDb" id="5476-C4YL16"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01530"/>
    <dbReference type="HOGENOM" id="CLU_002472_7_3_1"/>
    <dbReference type="OMA" id="KMTMLYK"/>
    <dbReference type="OrthoDB" id="276261at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03282">
        <property type="entry name" value="ABC_MSH4_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004070">
        <property type="entry name" value="MutS protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="6">
        <location>
            <begin position="630"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ43297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="803" mass="90840" checksum="AF97C9B8C01063BE" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL21</accession>
    <name>C4YL21_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_01535</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL21"/>
    <dbReference type="PaxDb" id="5476-C4YL21"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01535"/>
    <dbReference type="HOGENOM" id="CLU_2527222_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ43302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="84" mass="9629" checksum="87897C592F23AA0C" modified="2009-07-28" version="1">MSYRDSQYLPISSTGSFDRFQQTYNVSKIIDHKALSFNEAEYKKYSPLFLSTTFAISYGLSFASILVTITHTEYKTNDELGHNV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-02-08" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLF2</accession>
    <name>ATP25_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>ATPase synthesis protein 25, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ATP25</name>
        <name type="ORF">CAWG_01670</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable mitochondrial mRNA stabilization factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATP25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLF2"/>
    <dbReference type="SMR" id="C4YLF2"/>
    <dbReference type="PaxDb" id="5476-C4YLF2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01670"/>
    <dbReference type="HOGENOM" id="CLU_454918_0_0_1"/>
    <dbReference type="OMA" id="WLREQMM"/>
    <dbReference type="OrthoDB" id="107372at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140053">
        <property type="term" value="P:mitochondrial gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040152">
        <property type="entry name" value="Atp25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28087">
        <property type="entry name" value="ATPASE SYNTHESIS PROTEIN 25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28087:SF1">
        <property type="entry name" value="ATPASE SYNTHESIS PROTEIN 25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02410">
        <property type="entry name" value="RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000404464" description="ATPase synthesis protein 25, mitochondrial">
        <location>
            <begin position="39"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="580" mass="66837" checksum="4F0223950A05604B" modified="2009-07-28" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLG5</accession>
    <name>C4YLG5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLG5"/>
    <dbReference type="PaxDb" id="5476-C4YLG5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01683"/>
    <dbReference type="HOGENOM" id="CLU_010103_2_1_1"/>
    <dbReference type="OMA" id="FPIITHE"/>
    <dbReference type="OrthoDB" id="2684236at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF7">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="708" mass="79310" checksum="6CDDE6F1EDE99170" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLG7</accession>
    <name>C4YLG7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_01685</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLG7"/>
    <dbReference type="PaxDb" id="5476-C4YLG7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01685"/>
    <dbReference type="HOGENOM" id="CLU_022049_2_1_1"/>
    <dbReference type="OMA" id="VLEWLFK"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010109">
        <property type="entry name" value="Citrate_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01793">
        <property type="entry name" value="cit_synth_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF8">
        <property type="entry name" value="CITRATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="3">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ43448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="467" mass="52000" checksum="4B1385CDFF6CB7B7" modified="2009-07-28" version="1">MSAFRSIQRSTNVAKSTFKNSIRTYASAEPTLKQRLEEILPAKAEEVKQFKKEHGKTVIGEVLLEQAYGGMRGIKGLVWEGSVLDPIEGIRFRGRTIPDIQKELPKAPGGEEPLPEALFWLLLTGEVPTDAQTKALSEEFAARSALPKHVEELIDRSPSHLHPMAQFSIAVTALESESQFAQAYAKGANKSEYWKYTYEDSIDLLAKLPTIAAKIYRNVFHDGKLPAAIDSKLDYGANLASLLGFGDNKEFVELMRLYLTIHSDHEGGNVSAHTTHLVGSALSSPFLSLAAGLNGLAGPLHGRANQEVLEWLFKLREELNGDYSKEAIEKYLWKTLNSGRVVPGYGHAVLRKTDPRYTAQREFALKHMPDYELFKLVSNIYEVAPGVLTKHGKTKNPWPNVDSHSGVLLQYYGLTEQSFYTVLFGVSRAFGVLPQLILDRGIGMPIERPKSFSTEKYIELVKNINKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLK0</accession>
    <name>C4YLK0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_01718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLK0"/>
    <dbReference type="PaxDb" id="5476-C4YLK0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01718"/>
    <dbReference type="HOGENOM" id="CLU_949940_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="293" mass="34180" checksum="45986EE8A5DE2D3C" modified="2009-07-28" version="1">MIQSTNNPLISTQRIEINDEYEPENNSECSHKPTDSNIFRLFYNILKYLKVYILSTLFRRIEPSNRHLQSEENKEEDDEYINLSSEASSDIEIIAVNYKPTNDFHLINKTTRIQDNSILIDDTEETPFNIANNDSTTDLLRQLAKDRLKNRKTVTTQYGTDLTISKPIKYSSSRYQQWPVTQAETTTSIPEENFDHQPTLLDIEPITNKYQESILNYYVPTKPLSINSYSVIDNVISNFYIDKISSIYHKSHETLQQLITKERIDSQSKIKTLPSEQLNQVLKIWSQFSSINH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLM5</accession>
    <name>C4YLM5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_01744</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLM5"/>
    <dbReference type="SMR" id="C4YLM5"/>
    <dbReference type="PaxDb" id="5476-C4YLM5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01744"/>
    <dbReference type="HOGENOM" id="CLU_013985_5_3_1"/>
    <dbReference type="OMA" id="ICCRLET"/>
    <dbReference type="OrthoDB" id="47374at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000374">
        <property type="entry name" value="N-terminal acetyltransferase complex subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ43506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="175" mass="20010" checksum="D4FF0E9F66C3379D" modified="2009-07-28" version="1">MVRDIIALDDLTPNNLGVLKKINEVTLPIKYPESWYKQILESSNSIVQLAYYSELPVGGIKARTFHNNHNLKFNDFVNNKSSQVLSKTPNTVYIESFAVLEAYRGLGIGKKLLNYLIEETKKRFIHEIIIHVSVANHEAISWYKKQGFSQGELVPDYYKDQGLESPEAYIFTIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLM6</accession>
    <name>C4YLM6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_01745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLM6"/>
    <dbReference type="SMR" id="C4YLM6"/>
    <dbReference type="PaxDb" id="5476-C4YLM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01745"/>
    <dbReference type="HOGENOM" id="CLU_014210_0_0_1"/>
    <dbReference type="OMA" id="RAILHAH"/>
    <dbReference type="OrthoDB" id="1734229at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF0">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="115"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ43507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="673" mass="76586" checksum="C346BE425336A0DC" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLN1</accession>
    <name>C4YLN1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromatin modification-related protein EAF7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_01750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLN1"/>
    <dbReference type="PaxDb" id="5476-C4YLN1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01750"/>
    <dbReference type="HOGENOM" id="CLU_615372_0_0_1"/>
    <dbReference type="OMA" id="PKITHNE"/>
    <dbReference type="OrthoDB" id="5595141at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012423">
        <property type="entry name" value="Eaf7/MRGBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581">
        <property type="entry name" value="MRG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581:SF5">
        <property type="entry name" value="MRG_MORF4L-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07904">
        <property type="entry name" value="Eaf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="85"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="225"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="393"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ43512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="445" mass="50718" checksum="D5281A9D3D2FB08C" modified="2009-07-28" version="1">MATLDENNPSKQTHRHWSIENEIKLFSLLCDYKPAGKNKQHNIKIIINNINESLDSKEEPFSEYDVWNKLRSLYDLEKIDQIEELSTENTSTEETTNQVSSGSANITKDTKNAKTTLDAKEPIQDKKEMDKEKSESSSLSTPEPPQRRTRSARDTTKSKRNLRDTPKEKSQYNDEEITSGGAEKSKVEVSSTSDHTDDQSPTPGSTKKGLDEQTNDDMSDIEDVDKDKGDETIAKIKKENTSEQEEDKNKKQTEEEAEEEEEEGDHVSGDERESKNKDTSEDEDGEDNEDQDEDDVEVIEDSHTDKENESSSEESSPEPMTKRTRQRTRSTHEKTEHTSPNIKKRTRQSVKFDDKPAEPSDTGSRKRRAPPGSVSPPHPPKTRRRTRSVTHEIEEEDASTQSADDAEPEIIKVETRHTTRRSSRISMEPSSSTPNVRVRRSSRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLN9</accession>
    <name>C4YLN9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_01758</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">MFS antiporter that does not display functional linkage as drug transporter and performs functions that significantly affect biofilm development and virulence. No substrate for transport has been identified yet, but plays an important role in the growth in the host.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. CAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLN9"/>
    <dbReference type="PaxDb" id="5476-C4YLN9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01758"/>
    <dbReference type="HOGENOM" id="CLU_008455_8_4_1"/>
    <dbReference type="OMA" id="NWNYRRR"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001765">
        <property type="term" value="P:membrane raft assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000172">
        <property type="entry name" value="MFS multidrug resistance transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="43"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ43520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="509" mass="55407" checksum="A222B25933E0A498" modified="2009-07-28" version="1">MPGNREEFDIEKVLKSKKLEAIETSTEKKAPYTVFESTDKLLLIIVLSLVGFWSAISSPIYFPALPTLTKYFNTTPSVMNISVVAYLIFQGIAPTISSNLADTFGRRPVILGSIIVFCAVCIAISQTNVYWLLALLRCFQAAGIAPVFAISSGVAGDICTPANRGGMVGAVSGLQLAGNGIGGLVGAALISGFHTWRAIFIFLAIGGGVTFIFAFLVLAETSRRIVGNGSIMPKNVLNKAVLIYLPHFKNKITNDYSTLQPKGPFDILGPFKIFFQKEVFCTLLPSGMHFAAWTVSLTSLSTELESAKYNYSVMKVGLVYLPQGIACFIGSLIAGRCLNWYYRYRKNLYDKQMNDVPLNDRPPFNLVASRLTLTIVPLAMMVIGLSAFGWCLEYKKPIISIIISTILISFSASVMMSICTTMLVDLYPKQSGASASCVNLMRCWLAALFTGVLDKIISALGLGGTYTLLTGICLLTDLGLVYVLYTANQRFVNYVSPNQTAVNSDAEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLZ8</accession>
    <name>C4YLZ8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Armadillo-like helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_01873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLZ8"/>
    <dbReference type="PaxDb" id="5476-C4YLZ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01873"/>
    <dbReference type="HOGENOM" id="CLU_363686_0_0_1"/>
    <dbReference type="OMA" id="QINEYKW"/>
    <dbReference type="OrthoDB" id="2012278at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="856" mass="98559" checksum="DF5AECA4875D8FC8" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM35</accession>
    <name>C4YM35_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 9">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1 9">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_01910</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1 9"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM35"/>
    <dbReference type="PaxDb" id="5476-C4YM35"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01910"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OMA" id="FINNHPY"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000046">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000098">
        <property type="entry name" value="Mitogen-activated protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ43666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="372" mass="43317" checksum="B2EEC8F990EEECB3" modified="2009-07-28" version="1">MKKSTGPTQTRQVVFNISQNFKVLKILGEGAYGIVALAVHLPTETKVAIKKIEPFERPLFCLRTLREIKLLTKFKNHDNIVRLYDVQKPMNYDSFNEVYLIQEYMPSDLHNIIHTHLLSDQHVQYFIYQILKGLKMIHSARVIHRDLKPSNILVNEKCDLKICDFGLARLDTKHYNFDEAPRISMLTEYVATRWYRAPEIMLSASNYSTAIDLWSVGCILAELLTYRALFPGSDYINQLKLIFEVLGTPTDEDLQIIKSERAQKFIRSLPTKVKIDLSEFINNHPYRNIKHRGRDQVNPLAIDLLEKLLVFDPAKRITVQEALEHPYLNSYHDQLDEPITSPIPIEEFDFDIDKKNLDTNDLKKQIFEIVMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM41</accession>
    <name>C4YM41_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_01916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM41"/>
    <dbReference type="PaxDb" id="5476-C4YM41"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01916"/>
    <dbReference type="HOGENOM" id="CLU_637765_0_0_1"/>
    <dbReference type="OMA" id="EEHIFTQ"/>
    <dbReference type="OrthoDB" id="4026697at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ43672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="426" mass="47063" checksum="5A02EF2FA8FBA7C9" modified="2009-07-28" version="1">MLGIISSILRWSISPVIFIYNLIHSIISHTIIIPLKIFFKISIYIPFLKIPVIIPLVYLLELHEIKSTDWILAQIELFSITTLHFLIVCIFLGGIVGTIAGINMSAISIVLSGEPIVSTPATTTTTTSIASGKPSVKTAGVDKSKLEQVWEKSLGTGFNNENEGLGIKKKLEEVIIPDILPNISKSRIQLKLKQQQQQHQQIQKLKEQQGITLRNPEFNDTQKLRNVTINEELGGGIDNDNNKINEIHDIDDIESTGIEVVGLEDDGYAYTGGLRNRNQYPSKQKITARASGHASLNSPQIVSATTGRKSKDVNDETSTDSKTVKFADELVQDQPTGTSSSKRKAASTVIFEEEQTEMEQRNLPRGVNILQESEEVSSTDEGALSNIPEETETETETENETGTGTEEIEEHIFTQGESVTEDTSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM71</accession>
    <name>C4YM71_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_01949</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Polynucleotide 5'-kinase involved in rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Clp1 family. NOL9/GRC3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM71"/>
    <dbReference type="PaxDb" id="5476-C4YM71"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01949"/>
    <dbReference type="HOGENOM" id="CLU_010345_1_1_1"/>
    <dbReference type="OMA" id="EHVWKVR"/>
    <dbReference type="OrthoDB" id="4054781at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003052">
        <property type="entry name" value="Polynucleotide 5'-hydroxyl-kinase nol-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF3">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Clp1 P-loop" evidence="13">
        <location>
            <begin position="265"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ43702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="686" mass="77510" checksum="7FB64691B54C3146" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMK7</accession>
    <name>C4YMK7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">U3 small nucleolar ribonucleoprotein protein IMP4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMK7"/>
    <dbReference type="SMR" id="C4YMK7"/>
    <dbReference type="PaxDb" id="5476-C4YMK7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02089"/>
    <dbReference type="HOGENOM" id="CLU_040063_2_0_1"/>
    <dbReference type="OMA" id="IGTMSEQ"/>
    <dbReference type="OrthoDB" id="10253204at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000001">
        <property type="entry name" value="IMP4, U3 small nucleolar ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF2">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="79"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00040513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ43838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="283" mass="32923" checksum="7F3CA52A17FBEA0B" modified="2010-10-05" version="1">MIRKQARERREYLYRKALQLQESSLTEKRQQLKAALASGKSLSKELAEDEKLQRDFIYDESEQIEIDDEYSRLSGISDPKVVITTSRDPSVKLLQFSKEIKLMFPNSLKLNRGNYIISDLVSTCNRVQVSDMILLHEHRGVPSSLTVSHFPHGPTAIFTLHNVKLRHDLPNLGNVSESYPHLIFENFQSDLGKRVVKILQHLFPPGVKKDSSRVITFVNNDDYISVRHHVYVKTKDSVELSEIGPRFEMRLYEIRLGLPDNKDADVEWQMRRFIRTANRKNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN03</accession>
    <name>C4YN03_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_02241</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN03"/>
    <dbReference type="SMR" id="C4YN03"/>
    <dbReference type="PaxDb" id="5476-C4YN03"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02241"/>
    <dbReference type="HOGENOM" id="CLU_094271_0_1_1"/>
    <dbReference type="OMA" id="LTTYHDH"/>
    <dbReference type="OrthoDB" id="526653at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.10">
        <property type="entry name" value="Mediator complex, subunit Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021384">
        <property type="entry name" value="Mediator_Med21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381">
        <property type="entry name" value="RNA POLYMERASE II HOLOENZYME COMPONENT SRB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11221">
        <property type="entry name" value="Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="36"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ43984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="178" mass="20289" checksum="58297C735ADF5795" modified="2009-07-28" version="1">MADRLTQLQICLDQLIQQFNSTINYVNTSAEPSLLDDDDVNSYSNMAANAPLPQSQQQRQQQKKQQEPQQEIEQPQQQSNPESKSISPPKEKVSFDNVINELCTDLILKSRQIKMLIDSLPGIGVTPNEQMNLINELSDKLQAIEEERIQKIKEKDNLLNLLESMIKEVVNGITETRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN49</accession>
    <name>C4YN49_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">proteasome endopeptidase complex</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_02289</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN49"/>
    <dbReference type="SMR" id="C4YN49"/>
    <dbReference type="MEROPS" id="T01.011"/>
    <dbReference type="PaxDb" id="5476-C4YN49"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02289"/>
    <dbReference type="HOGENOM" id="CLU_035750_3_0_1"/>
    <dbReference type="OMA" id="KQHLFRH"/>
    <dbReference type="OrthoDB" id="429533at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03763">
        <property type="entry name" value="proteasome_beta_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000005">
        <property type="entry name" value="Proteasome subunit beta type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024689">
        <property type="entry name" value="Proteasome_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF4">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12465">
        <property type="entry name" value="Pr_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0888">Threonine protease</keyword>
    <feature type="domain" description="Proteasome beta subunit C-terminal" evidence="12">
        <location>
            <begin position="222"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ44030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="272" mass="29407" checksum="6B130ABB9EF9AC76" modified="2010-10-05" version="1">MPGLNFDNYQRNAFLTSKGFATPKATSTGTTIVGCKFKDGVVIAADTRATSGPIVADKNCEKLHRLAPKIWCAGAGTAADTEMVTQLIASNLELHALSQNRQPRVIAALTMLKQHLFKYQGHLGAYLIVAGVDPTGAHLMSVQAHGSTDIGKYQSLGSGSLNAMAVLETNFKEDMTRDEAIKLCSDAILAGVWNDLGSGSNVDVCVMEVGKDAELYRNYITPNVRIKKCKDYKFPRGTTAVLKQSIRDICDVEETVVNFNDNGDNMEVDTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN57</accession>
    <name>C4YN57_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN57"/>
    <dbReference type="SMR" id="C4YN57"/>
    <dbReference type="PaxDb" id="5476-C4YN57"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02297"/>
    <dbReference type="HOGENOM" id="CLU_823856_0_0_1"/>
    <dbReference type="OrthoDB" id="10409449at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="341" mass="38786" checksum="407BEBBF98E8C00B" modified="2010-10-05" version="1">MLIPQPKITISKRPHNQKSLTKAKKFSSNQLQDIFHEETTEIKSFVETSTPQPKQKAPRRKWPSYKSIEKTTFKKQKQKNTFASKHRAAHTPEEPNSYQGVHASPPLLIKDILNPVSLQQPCQAHENLCQNQYLDSNFHVSEAKCSNFIPISSSYKPPHNTFTRSYTCKSFSAAENHQSKPIHSDSENEYASTHKLPVNIPSIDELRRNIYLKKCSLNYILNPKRTAIDLSSNMQLSTTAPCYSVSSCSFDHELFSFSDKLSENISTLTNSDGKEQDYTLNDISSYINGTSVRMSSLANGNTNNKNDWLNQIKHVCNLHPPANSNDPLDLLCYDKYMIILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN77</accession>
    <name>C4YN77_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="10">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="10">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">4-hydroxybenzoate hexaprenyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="10">PHB:PPT</shortName>
            <shortName evidence="10">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">COQ2</name>
        <name evidence="11" type="ORF">CAWG_02317</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Mitochondrion inner membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
            <orientation evidence="2 10">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="10"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN77"/>
    <dbReference type="SMR" id="C4YN77"/>
    <dbReference type="PaxDb" id="5476-C4YN77"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02317"/>
    <dbReference type="HOGENOM" id="CLU_034879_2_2_1"/>
    <dbReference type="OMA" id="WCMIYDT"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000003">
        <property type="entry name" value="4-hydroxybenzoate polyprenyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ44058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="348" mass="39005" checksum="F443FE668C4F1CDA" modified="2010-10-05" version="1">MLVFRRPVYQLFTRGFAYSRIIRNEAKVPKFSPVELEAARLAREAGLGWLKHFPRKVIPYLELMRLEKPVGTWLLLLPCYWGITMASYSIAAPLWVTTKAIALFSVGALVMRGAGCTINDIWDRNLDNQVARTMERPITSGRVSVPQAVAWLGVQCFAGLAVLLSLPFECFYLGALSLPFVAAYPLFKRFTYYPQAMLSICFSWGCLLGFPAVGAPLNLWVAVPLFISNWIWCLTYDTIYAHQDKKFDIKAGIKSTALAWGDKTKPIMKGLTVAQAGFYGFAGFMNSMGPGFYIAGAYAIARLYNQILKVDLDNPKSCWSAFTSNIGTGFIFWYGIVFDYILLLLGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN78</accession>
    <name>C4YN78_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_02318</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN78"/>
    <dbReference type="SMR" id="C4YN78"/>
    <dbReference type="PaxDb" id="5476-C4YN78"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02318"/>
    <dbReference type="HOGENOM" id="CLU_115512_0_0_1"/>
    <dbReference type="OMA" id="QWRWDTG"/>
    <dbReference type="OrthoDB" id="1681166at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16456">
        <property type="entry name" value="RING-H2_APC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000469">
        <property type="entry name" value="Anaphase-promoting complex subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024991">
        <property type="entry name" value="RING-H2_APC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12861">
        <property type="entry name" value="zf-ANAPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="40"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ44059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="133" mass="15420" checksum="BC74DA9A470A9655" modified="2010-10-05" version="1">MKVEIVEWKSYCTWHWDLASSDGYVDELCGICRVSYDGTCPNCKYPGDQCPIVLGSGCTHNFHLHCILKWLEQETSKGLCPMCRQIFTFKEQKKQTPEEVAKLKKLIDGHKVMRERPEQADQEFEEYVPETIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN89</accession>
    <name>C4YN89_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="8">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_02329</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="8"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN89"/>
    <dbReference type="SMR" id="C4YN89"/>
    <dbReference type="PaxDb" id="5476-C4YN89"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02329"/>
    <dbReference type="HOGENOM" id="CLU_004585_7_0_1"/>
    <dbReference type="OMA" id="ENGWRGL"/>
    <dbReference type="OrthoDB" id="1470711at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17932">
        <property type="entry name" value="DEXQc_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.486.10">
        <property type="entry name" value="PCRA, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF46">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE HMI1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="11">
        <location>
            <begin position="4"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="12">
        <location>
            <begin position="266"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ44070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="637" mass="72129" checksum="4196D4A2D6B8562A" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNA7</accession>
    <name>C4YNA7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNA7"/>
    <dbReference type="PaxDb" id="5476-C4YNA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01363"/>
    <dbReference type="HOGENOM" id="CLU_660552_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="401" mass="44827" checksum="BA0C5134A2472F9F" modified="2009-07-28" version="1">MKVFGTTYDNVGLFKLKHPAEKWNVKKCIKMFFNDDKSDYSDELLRLAYLPATDYNIEFTILDSEVHNAKRGTRKAYSSRKSTHSYFLIGYNGKSVPKQTRYFLDNHRLTLCSTTKFCTACRTIGHTRWSCVNSSSCLKCGDPSHSTGHHNAWYDRQETDNQDNNDGYTTVGKKRKRKRKSKSNTTSTATANTATATKATATTSTATQATTQADTTKAVTTQATTQADTQPSAIQATTQADTQADTPPSAIQANTQADATEAVTTQADTQSTVQTSDKNNTQKISKVAPSQDVEQLDEINTPSWLASQAMLPIPEAPSQEVELNEGPDKLLFDENEYIETHDYFEPSDFYNSGDDDDYMDEDSEEENSEEEDSEDDDEMSIDAVSENEIDDLQKENENDQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNE4</accession>
    <name>C4YNE4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_01403</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNE4"/>
    <dbReference type="PaxDb" id="5476-C4YNE4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01403"/>
    <dbReference type="HOGENOM" id="CLU_021993_0_2_1"/>
    <dbReference type="OMA" id="ALQLLYW"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:001061">
        <property type="entry name" value="Bypass of stop codon protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="73"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ43177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="529" mass="58587" checksum="3C4868877CE391D3" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNE7</accession>
    <name>C4YNE7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U3 small nucleolar ribonucleoprotein protein IMP3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">U3 small nucleolar ribonucleoprotein protein imp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_01406</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNE7"/>
    <dbReference type="PaxDb" id="5476-C4YNE7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01406"/>
    <dbReference type="HOGENOM" id="CLU_097281_0_0_1"/>
    <dbReference type="OMA" id="FRIKHEQ"/>
    <dbReference type="OrthoDB" id="10248812at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000006">
        <property type="entry name" value="U3 small nucleolar ribonucleoprotein IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="12">
        <location>
            <begin position="4"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="11">
        <location>
            <begin position="109"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ43180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="183" mass="21591" checksum="35315749D6E8986B" modified="2009-07-28" version="1">MVRALKHHEKKLLKKVDFLDWKQDQGHRDTQVMRTYHIQNREDYHKYNKICGDIRKLAHKLSLLQPTDPFRIKHEQLLLEKLYNMGVLSTKSKISDLENKVTVSSLCRRRTGVVMCRLKMAETISDAVKFIEQGHVRVGPNVITDPAYLITRNLEDYLTWVDNSKIKRNVLKYKNKIDDFDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNJ4</accession>
    <name>C4YNJ4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_01456</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNJ4"/>
    <dbReference type="PaxDb" id="5476-C4YNJ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01456"/>
    <dbReference type="HOGENOM" id="CLU_006632_0_1_1"/>
    <dbReference type="OMA" id="HIFAFNW"/>
    <dbReference type="OrthoDB" id="2264294at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="777"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="791"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="817"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="830"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="845"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="875" mass="98194" checksum="AF3A314B621B70D0" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNK4</accession>
    <name>C4YNK4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WDR59/RTC1-like RING zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_01466</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YNK4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01466"/>
    <dbReference type="HOGENOM" id="CLU_001497_0_0_1"/>
    <dbReference type="OMA" id="HRRETCL"/>
    <dbReference type="OrthoDB" id="311712at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16488">
        <property type="entry name" value="mRING-H2-C3H3C2_Mio-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049567">
        <property type="entry name" value="WDR59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049566">
        <property type="entry name" value="WDR59_RTC1-like_RING_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17120">
        <property type="entry name" value="zf-RING_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="110"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="198"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="WDR59/RTC1-like RING zinc finger" evidence="7">
        <location>
            <begin position="1362"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="526"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="828"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="913"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="538"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="550"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="847"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="864"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="913"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1417" mass="160597" checksum="24085C111A1E3F34" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNR8</accession>
    <name>C4YNR8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_02851</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNR8"/>
    <dbReference type="PaxDb" id="5476-C4YNR8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02851"/>
    <dbReference type="HOGENOM" id="CLU_017517_2_0_1"/>
    <dbReference type="OMA" id="VYGPMYS"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
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    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ44577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="608" mass="67352" checksum="BF95F4AFFBD647AE" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP85</accession>
    <name>C4YP85_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="21">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CAWG_03031</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 21">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 21">Membrane</location>
            <topology evidence="2 21">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 21">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="21"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YP85"/>
    <dbReference type="PaxDb" id="5476-C4YP85"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03031"/>
    <dbReference type="HOGENOM" id="CLU_000846_3_2_1"/>
    <dbReference type="OMA" id="KMYYSRS"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140346">
        <property type="term" value="F:phosphatidylserine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000047">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000010">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
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        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
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        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="569"/>
            <end position="596"/>
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            <end position="666"/>
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        <location>
            <begin position="678"/>
            <end position="698"/>
        </location>
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            <end position="713"/>
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    <sequence length="788" mass="89380" checksum="CC20AD017868CD3C" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPB6</accession>
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        <recommendedName>
            <fullName evidence="1">Rit1 N-terminal domain-containing protein</fullName>
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        <name evidence="2" type="ORF">CAWG_03068</name>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">WO-1</strain>
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</entry>
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    <name>C4YPE6_CANAW</name>
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        <recommendedName>
            <fullName evidence="4">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">CAWG_03099</name>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPE6"/>
    <dbReference type="PaxDb" id="5476-C4YPE6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03099"/>
    <dbReference type="HOGENOM" id="CLU_056966_0_0_1"/>
    <dbReference type="OMA" id="ACADMSV"/>
    <dbReference type="OrthoDB" id="198885at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="36988" checksum="36451F2B53348785" modified="2009-07-28" version="1">MARLGPSTKMGDSNIGTVTNSIGGVGYNIARASGYVCDSTKFVSRVGNDAAGKTIQESVPGLDVGSGDTAQYVSMHDSSGELVVACADMSVIEEEFEVDHKASVAVYDCNLSPKTVSKALDNNEYNIIEPTSHVKARRIGEMELAVFPNNKVKLITPTVEELASIYDSMKDQFDDEWFGVLDAMKVDQIRERLDKKWYDKGVYQQCFQLLPFFQNILVKLGKDGVLLVSLCSTVEDYKSIPTTSPYRPKSIIYSKGNQVGAVVEYFPVPKDVEVVNVTGAGDTLVGYLAAKISELNWLHHEIGSAEQVWGKWESIYKAQLAAGLTLGCADSVSQEIANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPG2</accession>
    <name>C4YPG2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kynurenine 3-monooxygenase</fullName>
            <ecNumber evidence="11">1.14.13.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Biosynthesis of nicotinic acid protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Kynurenine 3-hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BNA4</name>
        <name evidence="14" type="ORF">CAWG_02361</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:20545"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the aromatic-ring hydroxylase family. KMO subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.9" evidence="11"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPG2"/>
    <dbReference type="PaxDb" id="5476-C4YPG2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02361"/>
    <dbReference type="HOGENOM" id="CLU_023210_0_1_1"/>
    <dbReference type="OMA" id="REFMFIA"/>
    <dbReference type="OrthoDB" id="10053569at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004502">
        <property type="term" value="F:kynurenine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070189">
        <property type="term" value="P:kynurenine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000129">
        <property type="entry name" value="Kynurenine 3-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01971">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027545">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028:SF2">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0274">FAD</keyword>
    <keyword evidence="2 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 11" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 11" id="KW-0521">NADP</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 11" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="13">
        <location>
            <begin position="10"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ44101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="456" mass="51555" checksum="1FA4A7AF6F5BDCF0" modified="2009-07-28" version="1">MSEEESQKTIGIVGAGLVGCLAALAFVKKGYDVTLFEYRPDPRTVDSSKRNLRSINLAVSSRGIRALQYVDPAMADRILEHVIPMKGRMIHDITGTKQESQVYGLNGESINSIDRSFLNNCLLDELDKSNVKILFKHKLVKLDTSNACRMTFIDGHNDAKTSTFDFVVGCDGAHSQFRYHLQKTMRMDYSQKYIDMQYLELYIPPSEDANNKFSIDANHLHIWPRHNFMLIALANKDGSFTSTFFSPWSVIEGISSSQEFVEFFRHNFPDAVGLIGEDALSSAFKSNPRGSLMQVSCYSYSNGKGIILGDAAHSMVPFYGQGMNCGFEDVRILMELIDTNNGDIEEAFKQYSAARKNDLDAICKLALDNYYEMSSKVVDIGYLIKKKLDYTLGKIFKNKWLPLYTMISFRDDIPYAMAIEIEKRQNRIMNNVGLGVLGTAAVYGLVKLGQYWNRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPI5</accession>
    <name>C4YPI5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_02386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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                <person name="Lin M.F."/>
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                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
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                <person name="Hoyer L.L."/>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPP9</accession>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
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                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
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                <person name="Nikolaou E."/>
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                <person name="Quinn J."/>
                <person name="Santos M.C."/>
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                <person name="Silverstein K.A."/>
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                <person name="Lorenz M.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="703"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ44188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
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    </evidence>
    <sequence length="711" mass="81126" checksum="C6CB2924638A80B9" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ75</accession>
    <name>C4YQ75_CANAW</name>
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        <recommendedName>
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        </recommendedName>
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        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ75"/>
    <dbReference type="PaxDb" id="5476-C4YQ75"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02630"/>
    <dbReference type="HOGENOM" id="CLU_033254_0_0_1"/>
    <dbReference type="OMA" id="NWLIKDI"/>
    <dbReference type="OrthoDB" id="10264870at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22933">
        <property type="entry name" value="HFD_HFI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024738">
        <property type="entry name" value="Hfi1/Tada1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12767">
        <property type="entry name" value="SAGA-Tad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="382"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="432"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ44364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="54831" checksum="6EC5A7420AF8E3BA" modified="2009-07-28" version="1">MTSQIADGSSTTTINPLKNGLAALKPTHQAHGTSTTTHLTNGSPKKIKSYKRLELERLIREFQNKLGKNWEKYHETLSLFLIGKLSRAELISTITPILKGKNLLKYHNKLLLLNFANSLKDNSSDLSTEFAGFWNKKAGKVTKNKNTQFERFKSVIMGLPVKERKRIIDISRDSGKKGKIATDIILTRHAILPKIPMIQDKEQQQLQVNNLVQWQQDVLNGINTPIATENYEIPDYDNLSRMMLMIMREHGLTGGLNPGVMEVMLLGLESHLKNIVETAIDVAKYRKNKYTNDNYIPYIKPNEDAQNISNENALPSSKDITLCIEDLHDTLEMYPHLVESEGPKLRLSNVMLENDDMINDDLNYYLPPKSIEYLAKERQAATTNNASTGTTKPGNNKGSSAGGSSAGATTNSPVVNKTDSMAAVSEKTDTNQPLQTPTATQTPVQTSAQAPASAPAQTPAPAQTPAPVSTPILRPDAHIGTTDELKWVLHDLVSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQA9</accession>
    <name>C4YQA9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_02666</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQA9"/>
    <dbReference type="SMR" id="C4YQA9"/>
    <dbReference type="PaxDb" id="5476-C4YQA9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02666"/>
    <dbReference type="HOGENOM" id="CLU_062828_2_1_1"/>
    <dbReference type="OMA" id="MNKKGAP"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000021">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="19"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="12">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ44398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="133" mass="14424" checksum="843E7BD7CE0546CA" modified="2009-07-28" version="1">MSGKGKVHGGKGKSSEIAKSSTSHSARAGLQFPVGRVKRYLKRNAQNKIRVGSKAAIYLTAVLEYLTAEVLELAGNAAKDLKVKRITPRHLQLAIRGDEELDNLIKATIAYGGVLPHINKALLLKVEKKKGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQL7</accession>
    <name>C4YQL7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_02776</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQL7"/>
    <dbReference type="SMR" id="C4YQL7"/>
    <dbReference type="PaxDb" id="5476-C4YQL7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02776"/>
    <dbReference type="HOGENOM" id="CLU_015166_6_3_1"/>
    <dbReference type="OMA" id="QFMMYEL"/>
    <dbReference type="OrthoDB" id="2019556at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080122">
        <property type="term" value="F:AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044610">
        <property type="term" value="F:FMN transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000285">
        <property type="entry name" value="Peroxisomal membrane protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="131"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="243"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ44506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="363" mass="39556" checksum="657BC0164EA80608" modified="2010-10-05" version="1">MSNQELAHAVSGAVGGALALGITYPLITLSTIAQTAAKKKEAEEASTTEDGKKPQPTVSLTTLEKIAHVIQNNAAYIAAKEILKEKGPLGLYSGLESALYGITLTNFIYYYFYELTSNVFLRANGKKRNGLSTIQSIITGAIAGAFTCVGSNPFWVANTRMMTEKKKEKTATAGDAADAKEENDNSSNSTFKALVNIVEQDGVGALFAGVLPALVLVINPIIQYTIFEQIKNIIIAKDGPKAFTAVKAFFIGAFGKLIATSLTYPYITLKSRMHIKRKKLNIDNQQQDEEKQLSMIQEIRKIVKEEGLEGLYAGLAVKLTQSIATAAFLFYFKEELFSGSVKLIEILRVFSFKKSLKSPVVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQN0</accession>
    <name>C4YQN0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">UvrD-like helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_02789</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YQN0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02789"/>
    <dbReference type="HOGENOM" id="CLU_000459_2_0_1"/>
    <dbReference type="OMA" id="PWHQSEL"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001147">
        <property type="term" value="F:transcription termination site sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21408">
        <property type="entry name" value="1B_Sen1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18042">
        <property type="entry name" value="DEXXQc_SETX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001152">
        <property type="entry name" value="tRNA-splicing endonuclease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044340">
        <property type="entry name" value="Helicase_Sen1_1B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024481">
        <property type="entry name" value="Helicase_Sen1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056474">
        <property type="entry name" value="SEN1_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23576">
        <property type="entry name" value="SEN1_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12726">
        <property type="entry name" value="SEN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="11">
        <location>
            <begin position="1298"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="876"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="954"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1829"/>
            <end position="2018"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="567"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1456"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="954"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1010"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1871"/>
            <end position="1881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1885"/>
            <end position="1895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1929"/>
            <end position="1948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1963"/>
            <end position="1982"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="1319"/>
            <end position="1326"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ44519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="2018" mass="227920" checksum="A82DFA4F3443EDD0" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQS8</accession>
    <name>C4YQS8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_04425</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YQS8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04425"/>
    <dbReference type="HOGENOM" id="CLU_001042_4_1_1"/>
    <dbReference type="OMA" id="CPALDNM"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000481">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000585">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="679"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="393"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="505"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="840"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="903"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1001"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1154"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ46081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1368" mass="155204" checksum="3B6F5DA23C30B8D9" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQT3</accession>
    <name>C4YQT3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Type I HSP40 co-chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_04430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQT3"/>
    <dbReference type="PaxDb" id="5476-C4YQT3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04430"/>
    <dbReference type="HOGENOM" id="CLU_017633_10_0_1"/>
    <dbReference type="OMA" id="THCFKHL"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="5"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="149"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="149"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ46086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="49678" checksum="4A1894959401B4A2" modified="2009-07-28" version="1">MLETDLYDVLEIDRSATNAEIKKAYRKLALKYHPDKVAEEEREYSETKFKEISFAYEILIDDVKRDEYDRYGTTDGLNGMPDFEFAGNPFDQFYGAGAGAQFNEYGGDDFYNFFNNMNGGGGARHQTKTNRTEDAHIEVDLTLEDLYKGKVIKTTSTRNIICTQCKGSGVKSSSVVSKQCSTCKGEGQVRKIKRVGPGMVAQTYVDCSTCQGIGKIYRTKDKCKLCHGARVIEETKILEFEIPKGSPDHGLIYKNGESDQFPGKVTGDVILEYKCKPHKVFTRKDDDLYIKVKVPLVDSICGFSKLVAVHLDGRGIKITTPKGKVIRPGDYLKLPGEGMPKSTPKKSWFNSTDSSKGDLYLKVEIEFPRDNWYVEKNDLTKIRNILPTKLTQEEKEVDVPEASIELFTDFSIIDSNQLPKYNHDRKYEQQGYEQSCAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQZ1</accession>
    <name>C4YQZ1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase SET5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">SET domain-containing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_04488</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl-[histone] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10024"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:9846"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:10025"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQZ1"/>
    <dbReference type="PaxDb" id="5476-C4YQZ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04488"/>
    <dbReference type="HOGENOM" id="CLU_031650_0_0_1"/>
    <dbReference type="OMA" id="LMAMYQQ"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042799">
        <property type="term" value="F:histone H4K20 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-TRIMETHYLTRANSFERASE SMYD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="7">
        <location>
            <begin position="107"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ46144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="473" mass="53852" checksum="8B1FEB4A8EC38EB1" modified="2009-07-28" version="1">MTQDISEKIEVISINDSQPEDSSPVVPHERQVVDCVIEIWKEDPSTESLGMSKLHALVKQKHPNWSISEKRVKSLLKQFGLAFNNQEQFTYAKEITSVMTPDIELPANVHIIMTSKRGKGLYAKRDIAKGDLIWSEEPLFFIPPLANVNLMKTASACTYCGKLLQRTESATVLKGLDCNVCSEVWCSIKCKHLDGNLHSLLKHNLYNPGSKKHKLIDAEAFLELQDYCLEEQWNALYAITLIYANCITDKSGVKQKQFDAMARVSQDVRYKALNSSAGTFDSLNGGALFVQEQQEHLWKIGYEKFLRVFPKKPVEYREFLFMMGTYNINNLDSNVFLTQSHLNHNCASNTSVETELNRTAGLKVIAGRDIKSGEELTTTYVNPSHTVHQRQRELRVNWGFICACAKCKDDLKQNERRKSSHNQQQNANNIRDMLKETKDAVGEEGIELEIPTEFNGERRKSVRFDEKVVAVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRE0</accession>
    <name>C4YRE0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alpha-1,3-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_04639</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRE0"/>
    <dbReference type="PaxDb" id="5476-C4YRE0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04639"/>
    <dbReference type="HOGENOM" id="CLU_015387_0_0_1"/>
    <dbReference type="OMA" id="CHEANNI"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000033">
        <property type="term" value="F:alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392:SF1">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ46293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="765" mass="89845" checksum="E6CCB806F914AED7" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRE1</accession>
    <name>C4YRE1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRE1"/>
    <dbReference type="PaxDb" id="5476-C4YRE1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04640"/>
    <dbReference type="HOGENOM" id="CLU_136352_0_0_1"/>
    <dbReference type="OMA" id="YRIANNV"/>
    <dbReference type="OrthoDB" id="5331396at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849:SF1">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="101" mass="11105" checksum="74E8F78A4189C6A4" modified="2009-07-28" version="1">MFSTSLQLIKSSLIHRSYSTTTTTNGAPIKVTTTTTRKKVGAFRGGFIGFLLGVTTTGGLSYYYLLDQYKLANTVVIADIVALQNSITNLEKHIKSLEERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRI0</accession>
    <name>C4YRI0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_04680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRI0"/>
    <dbReference type="SMR" id="C4YRI0"/>
    <dbReference type="PaxDb" id="5476-C4YRI0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04680"/>
    <dbReference type="HOGENOM" id="CLU_067876_2_0_1"/>
    <dbReference type="OMA" id="TAQWHQW"/>
    <dbReference type="OrthoDB" id="10255576at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052618">
        <property type="entry name" value="ComplexI_NDUFA12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470">
        <property type="entry name" value="ADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="117"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ46333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="22876" checksum="2F688803E6254C4D" modified="2010-10-05" version="1">MDIIKKKYPFWKRLLHKWQSRRDIPFRKKFFIGYDLYGNTYWEFTIDGNMSRLRRKLEPFRKELFEVDYFKTIPPQWLQWLRRTREHSPSLNELIEDQIRQQRIKILAQQADENWKLEKLRLEREQQLKLSNELNKVKLENEKFIEKQKRKEKEALLRVEDPWKQAEESKNENPIESTTIKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRS8</accession>
    <name>C4YRS8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Inositol oxygenase</fullName>
            <ecNumber evidence="4 14">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 14">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_04785</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="13 14">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4 14"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRS8"/>
    <dbReference type="PaxDb" id="5476-C4YRS8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04785"/>
    <dbReference type="HOGENOM" id="CLU_050259_0_0_1"/>
    <dbReference type="OMA" id="RYNTKYG"/>
    <dbReference type="OrthoDB" id="5151075at2759"/>
    <dbReference type="UniPathway" id="UPA00111">
        <property type="reaction ID" value="UER00527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050113">
        <property type="term" value="F:inositol oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF0">
        <property type="entry name" value="INOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="141"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="197"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="274"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ46431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="340" mass="40046" checksum="C2D2382E2307799D" modified="2010-10-05" version="1">MVNKVGKSTHDKSTNLDKSKGNILEKLDDDILHVNRIRGSLTNKTPITKTHSIDDELKLEEQSETAADENWQIASEYYKNIDIKAFRQYELACDRVKQFYEEQHEKQTVAYNIQARINFKTKTRARMTVWEGLEKLNKLLDDSDPDTELSQIDHALQTAEAIRRDGKPRWFQLVGLIHDLGKLLYFFDSRGQWDVVGDTFPVGCKFSKRIIFPDSFKNNPDFLNPLYNTKYGIYSKHCGLDKVMLSWGHDEYMYHVAKKNSTLPPEALAMIRYHSFYPWHQELAYSYLMDEHDKEMLKAVKAFNSYDLYSKIDQQYDVEELKPYYLELIDEFFPNKVIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRX2</accession>
    <name>C4YRX2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Membrane insertase YidC/Oxa/ALB C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_04830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRX2"/>
    <dbReference type="PaxDb" id="5476-C4YRX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04830"/>
    <dbReference type="HOGENOM" id="CLU_029282_2_1_1"/>
    <dbReference type="OMA" id="WQRKRIV"/>
    <dbReference type="OrthoDB" id="2148490at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF65">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="8">
        <location>
            <begin position="107"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ46475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="294" mass="33812" checksum="D988AC4BAB6CBE44" modified="2009-07-28" version="1">MTSSFQTVHEFSGLPWWALIPLTTFTLRSVWTLPLAILQRKRIQKQSQLRPLVSAMNPILKLNLARRVQQAKKKLENNSNTKEDITSIQASSTLSNMKYEQILLLSAKEARKRQKELFAKNGVQLWKNFILPAFQVPLWIMMSITMRDLSGWSSWDNTHNKALDPSLYEEGILWFQDLSIADPMHVFPVILGITALCNIEWTLKTLELSRLTKKLKFRPTLTDAFGNLTKMSIVFMMAISLHAPAALTIYWISSQLYSLLQNVMMDLMLPISFTPKKRINYAKIKNDNAVNVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS20</accession>
    <name>C4YS20_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_04878</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS20"/>
    <dbReference type="SMR" id="C4YS20"/>
    <dbReference type="PaxDb" id="5476-C4YS20"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04878"/>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_1"/>
    <dbReference type="OMA" id="CGGSTIR"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03337">
        <property type="entry name" value="TCP1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000037">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000073">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000005">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012719">
        <property type="entry name" value="Chap_CCT_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02344">
        <property type="entry name" value="chap_CCT_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ46523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="529" mass="58642" checksum="4814F37339C41E56" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSM2</accession>
    <name>C4YSM2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSM2"/>
    <dbReference type="SMR" id="C4YSM2"/>
    <dbReference type="PaxDb" id="5476-C4YSM2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05090"/>
    <dbReference type="HOGENOM" id="CLU_025462_2_0_1"/>
    <dbReference type="OMA" id="TYRYPIQ"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="360" mass="42199" checksum="776BB11A0473FD64" modified="2010-10-05" version="1">MLLNLVIIVVIILIGYLTVSHFWFNPSHSSVINNIPPVASNFKWETQQPLPIRPFVNKKNFNPSMAIKNISDTPQDWLLIENTYYNNVRQRQKHIALEPEILTFIHNNNRTKQAVGEFYDMVTQFLLSRYPMYFKYDFWSGIVTNTITNDKFPKYSKSLIPNYQSMVEILGRNIEEDFLILIKNNPHDKEEEYIMRASLNGFPAGFDPRVNFNQPISFIHQPVPQYKSRLQFSMTKFFNNSQPDKLWVRHNWGIQTHNSYFNMDTNHGRPGDKIHQLSMNEIDFDNEGCCLRCERQLFTRMPQSGAIIMTIRTYLTPIKTIKQEGLGKELSRAIDGLPDDLAFYKKRNSWGEAVKEYLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSN3</accession>
    <name>C4YSN3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_05101</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSN3"/>
    <dbReference type="PaxDb" id="5476-C4YSN3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05101"/>
    <dbReference type="HOGENOM" id="CLU_024893_1_1_1"/>
    <dbReference type="OMA" id="DAHNISK"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="7">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="173"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="324"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="72"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="173"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ46736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="431" mass="44596" checksum="9CFEAAF05C11A2C8" modified="2009-07-28" version="1">MYQSSGYCEQQCAGYRVAALKNGNECYCGDVDPTSQSNGCNIKCSGWPSDTCGGSSAYMVYINADADSQAQSSSTSSTSTSSTSSSKSTSSSSSSTSSSSTSTEQPSTTTIQATTTEQTTAEPESTEQPETTEKPETTSSSSRTTTQPRTTTVVSTSVQNGTPSVVYKTIVATPSSNPSTSSSSSSSSSSSTIPPSTSTSSSPSETGSNDKGKNQSKSSVSGGTIAGAVVGSVAGTALVAGLVFLFCWYRRKKQDEYDDDVDDQFTLSGPKQEMEQHPYSTIGGGGAGGGGGAAMLDPNPFLIAGGYNNFDTSQQQTPRQQIISNGTVTGSGGYGHNHKISSSGTSGDGNHSFGSQTDTEFAFYDYSNSNNNNNNNNTTTSPNINNNNNNANNGLLHTDSPNPEFGRRRLSNGSLPDMIARNPGSLKVVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTQ8</accession>
    <name>C4YTQ8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-dependent molecular chaperone HSP82</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_05553</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EEQ46999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="SMR" id="C4YTQ8"/>
    <dbReference type="BindingDB" id="C4YTQ8"/>
    <dbReference type="ChEMBL" id="CHEMBL1293251"/>
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    <dbReference type="HOGENOM" id="CLU_006684_1_3_1"/>
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        <property type="component" value="Chromosome 7"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
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    <dbReference type="GO" id="GO:0051082">
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        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="9">
        <location>
            <begin position="29"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="216"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="676"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
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        <location>
            <position position="82"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="102"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="122"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
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            <position position="174"/>
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        <ligand>
            <name>ATP</name>
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            <position position="377"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="SMART" id="SM00387"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ46999.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="707" mass="80823" checksum="3BF614C70F2E5446" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pichiomycetes</taxon>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
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                <person name="Arnaud M.B."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
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                <person name="Hoyer L.L."/>
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                <person name="Logue M.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
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        <property type="match status" value="7"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="50"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="51"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="110"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="191"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="245"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="298"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="357"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="421"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ47057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="493" mass="54023" checksum="4E8C34226384C450" modified="2009-07-28" version="1">MVALKREAEPRENGKSKKAKTSLATSSFVLHSYSKLPNINEYAKAKSTPLDVFVWGTGSMCELGLGPSAKNKEVKRPRLNPYLTEEKLGGTKIVDFAVGGMHTLALDGKNRIWSWGGNDSGVLGRDTSQAKEVLKDIDGKNGNDDDDDDDDEDGDLNEAESTPALVENLPEGEIVQLAATDNLSAALLSNGDVYAWGCFRCNEGLLGFLRDEIKLQKTPLKIKELKNIVQLAAGKDHLLALDSKGIVYAWGNGQQYQLGRRILERHRYRSLEPQQFGLYNIKYIASGDFHCFAIDHSDNVYAWGLNQYGQCALTGDNGELEDGSVLMKPTLIPELSHKGIKEIAAGEHHTLALTEDGQVYAWGRYDMKEIGIPKDKLPKSTFKDQHGNPRSVPVPTKLEFAVKIKTIGVGSHHSFAVTEDGVVYAWGFAETYGPGLGPSIDDVEKPTRIVNTATKNEDILLIGAGGQFSVSGGVKIEDEEKAEVKLDKYEDLE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1992-12-01" modified="2026-01-28" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>P28868</accession>
    <accession>C4YS30</accession>
    <name>GPA1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>Guanine nucleotide-binding protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CAG1</name>
        <name type="ORF">CAWG_04888</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1992" name="Mol. Cell. Biol." volume="12" first="1977" last="1985">
            <title>A G-protein alpha subunit from asexual Candida albicans functions in the mating signal transduction pathway of Saccharomyces cerevisiae and is regulated by the a1-alpha 2 repressor.</title>
            <authorList>
                <person name="Sadhu C."/>
                <person name="Hoekstra D."/>
                <person name="McEachern M.J."/>
                <person name="Reed S.I."/>
                <person name="Hicks J.B."/>
            </authorList>
            <dbReference type="PubMed" id="1569935"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Involved in the mating pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text>G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="M88113">
        <property type="protein sequence ID" value="AAA34324.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A44384">
        <property type="entry name" value="A44384"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P28868"/>
    <dbReference type="SMR" id="P28868"/>
    <dbReference type="PaxDb" id="5476-P28868"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04888"/>
    <dbReference type="HOGENOM" id="CLU_014184_6_0_1"/>
    <dbReference type="OMA" id="QVIWADA"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000015">
        <property type="entry name" value="G protein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000563">
        <property type="entry name" value="Guanine nucleotide-binding protein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0519">Myristate</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0807">Transducer</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000203595" description="Guanine nucleotide-binding protein subunit alpha">
        <location>
            <begin position="2"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="G-alpha" evidence="4">
        <location>
            <begin position="40"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1 motif" evidence="4">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Not present in other G-proteins">
        <location>
            <begin position="125"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2 motif" evidence="4">
        <location>
            <begin position="249"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3 motif" evidence="4">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4 motif" evidence="4">
        <location>
            <begin position="341"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5 motif" evidence="4">
        <location>
            <begin position="399"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="lipid moiety-binding region" description="N-myristoyl glycine" evidence="2">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-palmitoyl cysteine" evidence="2">
        <location>
            <position position="3"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAA34324." evidence="5" ref="1">
        <original>D</original>
        <variation>S</variation>
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAA34324." evidence="5" ref="1">
        <original>F</original>
        <variation>V</variation>
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAA34324." evidence="5" ref="1">
        <original>E</original>
        <variation>V</variation>
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P08539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P18064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="429" mass="49203" checksum="82EE05F3682CB5F0" modified="2011-10-19" version="5">MGCGASVPVDDDEIDPFLQDKRINDAIEQSLQLRQQNSKKGVKLLLLGAGESGKSTVLKQLKLLHKGGFTQQERRQYSHVIWCDVIQSMKVLIIQARKLKIKLDCDQPNNSLIPYKQIILRSDPLKQIDADVAGGTDFLNDFVVKYSEENKNKRRLKSTGTTDIWGKDDDSNINSDAINQALESSLNKDSEQFTRLSIAEAIHKLWKLDSGIKKCFDRSNEFQLEGSADYYFDNVFNFADTNYLSTDLDILKGRIKTTGITETDFLIKSFQFKVLDAGGQRSERKKWIHCFEDITAVLFVLAISEYDQNLFEDERVNRMHESIVLFDSLCNSKWFANTPFILFLNKIDIFENKIKKNPLKNYFPDYDGKPDDTNEAIKFFETNFLKINQTNKPIYVHRTCATDSKSMKFVLSAVTDMIVQQNLKKSGIM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2026-01-28" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>Q92211</accession>
    <accession>C4YP56</accession>
    <name>G3P_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <shortName>GAPDH</shortName>
            <ecNumber>1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">TDH1</name>
        <name type="synonym">GAP</name>
        <name type="synonym">TDH3</name>
        <name type="ORF">CAWG_02997</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="J. Bacteriol." volume="179" first="4992" last="4999">
            <title>The glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase of Candida albicans is a surface antigen.</title>
            <authorList>
                <person name="Gil-Navarro I."/>
                <person name="Gil M.L."/>
                <person name="Casanova M."/>
                <person name="O'Connor J.E."/>
                <person name="Martinez J.P."/>
                <person name="Gozalbo D."/>
            </authorList>
            <dbReference type="PubMed" id="9260938"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location>Secreted</location>
            <location>Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12"/>
    <dbReference type="EMBL" id="U72203">
        <property type="protein sequence ID" value="AAC49800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="PDB" id="7U4S">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.68 A"/>
        <property type="chains" value="A/B/C/D=1-335"/>
    </dbReference>
    <dbReference type="PDBsum" id="7U4S"/>
    <dbReference type="AlphaFoldDB" id="Q92211"/>
    <dbReference type="SMR" id="Q92211"/>
    <dbReference type="MoonDB" id="Q92211">
        <property type="type" value="Curated"/>
    </dbReference>
    <dbReference type="MoonProt" id="Q92211"/>
    <dbReference type="PaxDb" id="5476-Q92211"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02997"/>
    <dbReference type="HOGENOM" id="CLU_030140_0_3_1"/>
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    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0030312">
        <property type="term" value="C:external encapsulating structure"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="GAPDH_I_N"/>
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        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
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    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
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        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
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        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
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    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
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    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
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        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GAPDH"/>
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    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
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            <begin position="1"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
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            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="13"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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    <feature type="binding site" evidence="1">
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            <position position="79"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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    <feature type="binding site" evidence="1">
        <location>
            <begin position="150"/>
            <end position="152"/>
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        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
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    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
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        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
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    <feature type="binding site" evidence="1">
        <location>
            <begin position="210"/>
            <end position="211"/>
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        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="233"/>
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        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="315"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
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    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="1">
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            <position position="178"/>
        </location>
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    <feature type="sequence conflict" description="In Ref. 1; AAC49800." evidence="3" ref="1">
        <original>L</original>
        <variation>V</variation>
        <location>
            <position position="104"/>
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    <feature type="sequence conflict" description="In Ref. 1; AAC49800." evidence="3" ref="1">
        <original>V</original>
        <variation>L</variation>
        <location>
            <position position="234"/>
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    <feature type="sequence conflict" description="In Ref. 1; AAC49800." evidence="3" ref="1">
        <original>Q</original>
        <variation>P</variation>
        <location>
            <position position="259"/>
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    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAC49800." evidence="3" ref="1">
        <original>R</original>
        <variation>K</variation>
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAC49800." evidence="3" ref="1">
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            <begin position="332"/>
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    <feature type="strand" evidence="4">
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    <feature type="helix" evidence="4">
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            <begin position="12"/>
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    <feature type="strand" evidence="4">
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            <begin position="151"/>
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            <begin position="169"/>
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            <begin position="195"/>
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        <location>
            <begin position="317"/>
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    <evidence type="ECO:0000250" key="1"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10009"/>
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    </evidence>
    <evidence type="ECO:0000305" key="3"/>
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        <source>
            <dbReference type="PDB" id="7U4S"/>
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    <sequence length="335" mass="35833" checksum="24353A29CD3E332E" modified="2011-10-19" version="2">MAIKIGINGFGRIGRLVLRVALGRKDIEVVAVNDPFIAPDYAAYMFKYDSTHGRYKGEVTASGDDLVIDGHKIKVFQERDPANIPWGKSGVDYVIESTGVFTKLEGAQKHIDAGAKKVIITAPSADAPMFVVGVNEDKYTPDLKIISNASCTTNCLAPLAKVVNDTFGIEEGLMTTVHSITATQKTVDGPSHKDWRGGRTASGNIIPSSTGAAKAVGKVIPELNGKLTGMSLRVPTTDVSVVDLTVRLKKAASYEEIAQAIKKASEGPLKGVLGYTEDAVVSTDFLGSSYSSIFDEKAGILLSPTFVKLISWYDNEYGYSTRVVDLLEHVAKASA</sequence>
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<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
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    <name>C4YCR0_CANAW</name>
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        <recommendedName>
            <fullName evidence="3 11">KRR1 small subunit processome component</fullName>
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        <alternativeName>
            <fullName evidence="11">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_00294</name>
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    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Essential for vegetative growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with MPP10, KRI1 and with ribosomal proteins RPS1A, RPS4A, RPS4B, RPS8A, RPS8B, RPS11A, RPS11B, RPS13, RPS24, RPS25, RPL4A, RPL7B, RPL8, RPL23, RPL25 and RPL28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the KRR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCR0"/>
    <dbReference type="SMR" id="C4YCR0"/>
    <dbReference type="PaxDb" id="5476-C4YCR0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00294"/>
    <dbReference type="HOGENOM" id="CLU_040185_0_2_1"/>
    <dbReference type="OMA" id="TPDIDKW"/>
    <dbReference type="OrthoDB" id="441223at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000011">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 11" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="13">
        <location>
            <begin position="122"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="280"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="343"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ42096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="358" mass="41988" checksum="A4975D7D45E476D5" modified="2010-10-05" version="1">MPSTHNRDKPWDTPDIDKWALEEFKPEHNASGLHFAEESSFMTLFPKYREQYLRSIWSDVTKALDKHFIKCELDLVEGSMTVKTTTKTFDPAMIIKARDLIKLLARSVPFPQAVKILQDDIACDVIKIGNFVANKDRFIKRRQRLVGPNGNTLKALELLTKCYILVQGNTVSAMGPFKGLKEVRRVVEDCMKNIHPIYYIKELMIKQELSKNPALANEDWSRFLPSFKKRNVARKKKTSKKSVEKKVYTPFPPAQQPRKIDLQIESGEYFLGKKEKELKKLQEKRSKQEEVSETKRQERAKDFEAPEEEVYENKLLKKEKKEKKEKKDKKEKKDKKDKKKKRSHDDEDHSPEPKKSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD07</accession>
    <name>C4YD07_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L44</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_00394</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD07"/>
    <dbReference type="SMR" id="C4YD07"/>
    <dbReference type="PaxDb" id="5476-C4YD07"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00394"/>
    <dbReference type="HOGENOM" id="CLU_114645_2_1_1"/>
    <dbReference type="OMA" id="CKKHTIH"/>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ42193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="106" mass="12226" checksum="6744A27ED05A9818" modified="2009-07-28" version="1">MVNVPKTRKTYCKGKECRKHTQHKVTQYKAGKASLFAQGKRRYDRKQSGYGGQTKQIFHKKAKTTKKVVLRLECVVCKTKAQLPLKRCKHFELGGDKKQKGQALQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD42</accession>
    <name>C4YD42_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_00430</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YD42"/>
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    <dbReference type="HOGENOM" id="CLU_040438_0_0_1"/>
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    <dbReference type="OrthoDB" id="515401at2759"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Siderophore transcription factor SreA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
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        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF335">
        <property type="entry name" value="IRON-SENSING TRANSCRIPTIONAL REPRESSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="54"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="178"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="222"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="354"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="472"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="364"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="476"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ42228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="517" mass="56330" checksum="6F449830A5975D59" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD48</accession>
    <name>C4YD48_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_00436</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PET100 family.</text>
    </comment>
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        <property type="protein sequence ID" value="EEQ42234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00436"/>
    <dbReference type="HOGENOM" id="CLU_156745_3_0_1"/>
    <dbReference type="OMA" id="DKDEIHA"/>
    <dbReference type="OrthoDB" id="18175at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018625">
        <property type="entry name" value="Pet100"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968:SF1">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ42234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="76" mass="9057" checksum="CA004AAF17CED037" modified="2009-07-28" version="1">MYYVGLDTDKKFNLPGFWPDPSTLNQIPKEPHEIQAEIARIKRARLEKRKRLEEKARELGISEEDFEEEQQQEILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD71</accession>
    <name>C4YD71_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Malate synthase</fullName>
            <ecNumber evidence="3 10">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_00461</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the malate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="3 10"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00461"/>
    <dbReference type="HOGENOM" id="CLU_018928_3_0_1"/>
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    <dbReference type="OrthoDB" id="186072at2759"/>
    <dbReference type="UniPathway" id="UPA00703">
        <property type="reaction ID" value="UER00720"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="malate_synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.360:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="entry name" value="Malate synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Malate synthase, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019830">
        <property type="entry name" value="Malate_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048355">
        <property type="entry name" value="MS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048356">
        <property type="entry name" value="MS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01344">
        <property type="entry name" value="malate_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902:SF1">
        <property type="entry name" value="MALATE SYNTHASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20659">
        <property type="entry name" value="MS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20656">
        <property type="entry name" value="MS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="MS_TIM-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001363">
        <property type="entry name" value="Malate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="Malate synthase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00510">
        <property type="entry name" value="MALATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Malate synthase N-terminal" evidence="12">
        <location>
            <begin position="13"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase TIM barrel" evidence="11">
        <location>
            <begin position="170"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase C-terminal" evidence="13">
        <location>
            <begin position="423"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001363-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ42257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="551" mass="62529" checksum="442BA311D205ADC6" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDQ6</accession>
    <name>C4YDQ6_CANAW</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_00653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="HOGENOM" id="CLU_1570414_0_0_1"/>
    <dbReference type="OrthoDB" id="10295318at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ42442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="170" mass="18573" checksum="56D99D27DEFBDFEF" modified="2009-07-28" version="1">MSAMLPTIAPNFTVSSPSSVASANGTTNETVVIPRPDLTDNTVTSAPSTVASSTSHLATNIMSQPQSSTVTLSDAPASKLVTIRKRLQDLDQKLAPKSVKLTDIARIHEHLAVIHDPNSKIKQLYGEYYDLLWSISASERSKEEKNALKQFEIGSLPSYRTIDSRISFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDR6</accession>
    <name>C4YDR6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_00663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDR6"/>
    <dbReference type="PaxDb" id="5476-C4YDR6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00663"/>
    <dbReference type="HOGENOM" id="CLU_847296_0_0_1"/>
    <dbReference type="OMA" id="WEVGNCK"/>
    <dbReference type="OrthoDB" id="4011186at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ42452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="319" mass="37553" checksum="D3FB9C047A7B5953" modified="2009-07-28" version="1">MNNSIWQFLNKSKADVISHSVKCIIPQQVSLPTNLHPPTSAFNSYTNKFKNAQDFYDHIQPIPFQTNTLPKDRSEIRGVDSSIHRFLFNKFKWKEYPPILKNEFMMIQFFSHHHIISNFRKSNIAFAVNIYTIPLFNSIRLRDAMNRYRGRYSNLQFFKTKTSPIQSACGRSQTKKLFRELFVKALQTSGVINKERNDNTSVTDKLKGVYAIHIYKVPITTEQKDKVVQDYSAMINKIVNDKNIWNTLNQAARRSKSVNLQRVLPNVRFSWEVGNCKDDRIRFPFINMTEIQSKKSEYTKRFKKNANKQRNQNQQDIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDS5</accession>
    <name>C4YDS5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDS5"/>
    <dbReference type="PaxDb" id="5476-C4YDS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00672"/>
    <dbReference type="HOGENOM" id="CLU_1970241_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="127" mass="14229" checksum="B446E0D17A25330B" modified="2009-07-28" version="1">MTLLTFQEMRESSKRFGVNEVTKRRNSFNENHKGGNKKFKKGNNNGKGKNNKNENDNGNGTEDKETKLEKVEEIDSTKENTEEVAAKETAPESTEKTETKEAPAPTTETETETKTEVTEATEAAKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YE33</accession>
    <name>C4YE33_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_00784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YE33"/>
    <dbReference type="PaxDb" id="5476-C4YE33"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00784"/>
    <dbReference type="HOGENOM" id="CLU_016097_0_0_1"/>
    <dbReference type="OMA" id="RERHIDD"/>
    <dbReference type="OrthoDB" id="4027577at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="614"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ42569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="741" mass="86263" checksum="C1804C236A5575FC" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YE71</accession>
    <name>C4YE71_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_00824</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YE71"/>
    <dbReference type="PaxDb" id="5476-C4YE71"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00824"/>
    <dbReference type="HOGENOM" id="CLU_049344_1_2_1"/>
    <dbReference type="OMA" id="RTWSAYH"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000981">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="43"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ42607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="306" mass="36174" checksum="A354831F209C05D6" modified="2009-07-28" version="1">MATYSEMTFNSQHYDDSRPNYPEPFYKELIKYHTKRGDTKLAIDIGCGSGFVAFQLVNYFDSIIGTDPSSTMIEQCNSNIPPEWLRNSPKKISFMKGTAEHHPVSIKKNSVDLITGAECCHWVNHKQFFDESYRVLKSNGTLAYWFYKDPVFIGYPEANKVYTNYIYNSSFDESPDEEFERYMGPYYQQPGHDYLRSLMKEIEVPTDKFYDIVRHEYISDIHGAPKENEDPYITKTPLFIKKTITMKWFLDYVKSWSAYHTWMTHHGDKYDIAEKFVAELKQKMNWNDDTEIDVIWDTVYTFARKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEA1</accession>
    <name>C4YEA1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Raptor N-terminal CASPase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_00855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat RAPTOR family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YEA1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00855"/>
    <dbReference type="HOGENOM" id="CLU_001136_0_2_1"/>
    <dbReference type="OMA" id="TEVCTND"/>
    <dbReference type="OrthoDB" id="10262360at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001718">
        <property type="entry name" value="AaceriADR331Cp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000947">
        <property type="entry name" value="Ubiquitin-binding TORC1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001464">
        <property type="entry name" value="Ubiquitin-binding TORC1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="6">
        <location>
            <begin position="64"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1299"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="907"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="907"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ42637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1409" mass="160015" checksum="C1482C739BEDBCB0" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEL1</accession>
    <name>C4YEL1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEL1"/>
    <dbReference type="PaxDb" id="5476-C4YEL1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00968"/>
    <dbReference type="HOGENOM" id="CLU_1651925_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="160" mass="19266" checksum="8853CB80532C72A4" modified="2009-07-28" version="1">MFLCGEVKEEREIKRKRKRRERDQKVAYNSRSQIYNKQNKNDTKKEKVYCFVCAWCEMEPKRQEGMELELEWFLFYSSPSCDKKTLLSRTKDKNSFHFSSSLLSCSLLLTLSVRNLHHQIPFLFFFLQELFFLYSPLLFYFHFSLSSLSLSLLVSFTSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YER9</accession>
    <name>C4YER9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial inner membrane protease subunit</fullName>
            <ecNumber evidence="9">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_01027</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase S26 family. IMP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="9"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YER9"/>
    <dbReference type="SMR" id="C4YER9"/>
    <dbReference type="MEROPS" id="S26.010"/>
    <dbReference type="PaxDb" id="5476-C4YER9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01027"/>
    <dbReference type="HOGENOM" id="CLU_028723_4_3_1"/>
    <dbReference type="OMA" id="LCKGPSM"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.109.10:FF:000018">
        <property type="entry name" value="Mitochondrial inner membrane protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 9 11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S26" evidence="10">
        <location>
            <begin position="14"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ42805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="183" mass="20587" checksum="5776F94EA81486AD" modified="2010-10-05" version="1">MTFFESLKFVGSTLSWTLRAGCIAHLIHENVYEFTETRGESMLPTLQNQHDYVHALKKYKYGRNLVMGDCIVAIKPSDPSHRICKRITGMPGDMILVDPSSSSELTNSPNEIIQHDGYNKYIRIPEGHVWCTGDNLCHSLDSRSYGVVPMGLITGKIVAANSMSEGISTLYNFRWITNTLQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF11</accession>
    <name>C4YF11_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homoserine dehydrogenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_01121</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF11"/>
    <dbReference type="PaxDb" id="5476-C4YF11"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01121"/>
    <dbReference type="HOGENOM" id="CLU_2291337_0_0_1"/>
    <dbReference type="OrthoDB" id="67851at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009067">
        <property type="term" value="P:aspartate family amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011147">
        <property type="entry name" value="Bifunc_Aspkin/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070:SF5">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homoserine dehydrogenase catalytic" evidence="3">
        <location>
            <begin position="15"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ42897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="101" mass="10899" checksum="3DFD2DD16C008004" modified="2009-07-28" version="1">MEKLPNYDADIQKVKDEAFAENKVLRFVGKVDLNTNKVSVEIGKYGFDHPFASLKGSDNVVSIKTGRYPNPLIVQGAGAGAEITAHGVLADTIKIAERIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF45</accession>
    <name>C4YF45_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="3">1.3.1.124</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_01156</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="3"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF45"/>
    <dbReference type="SMR" id="C4YF45"/>
    <dbReference type="PaxDb" id="5476-C4YF45"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01156"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_1"/>
    <dbReference type="OMA" id="MQAHVCA"/>
    <dbReference type="OrthoDB" id="2136131at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ42931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="292" mass="30672" checksum="2FB9986B0E4C0B9A" modified="2009-07-28" version="1">MPNTLDQSYVEKGAWKQDLFRGKVVFITGGAGSICRVQAEALVLLGANAAIIGRNQEKTTTAAKEIASLRSDAKVLGIGNIDVRKVQNLKEAVDKTVEELGRIDFVIAGAAGNFLCDFNHLSSNAFKSIVDIDLLGSFNTVKATFEQLRKNKGAILFVSATLHYYGVPFQIGVGAAKAGVDALSNALAVELGPLGIRSNAIAPGPIDGTEGMSRLSRSSKDETIKNVPLQRMGTTQDIADGTVYLFSPAASYVTGDVLVVDGGSWQVSSGVGAKDYPVTLLNAINAPKGGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF83</accession>
    <name>C4YF83_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_01195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF83"/>
    <dbReference type="SMR" id="C4YF83"/>
    <dbReference type="PaxDb" id="5476-C4YF83"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01195"/>
    <dbReference type="HOGENOM" id="CLU_028601_0_1_1"/>
    <dbReference type="OMA" id="NEYEIMG"/>
    <dbReference type="OrthoDB" id="15688at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="42"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ42969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="276" mass="31220" checksum="B00FBBE88CC37CDC" modified="2010-10-05" version="1">MYRNWLYFGRDSIDNLLNNYSFLLPRIRKTRQLKLNMDSKSTCVSIGKFPFDYTEEQVRDIARSVGPVLDVKLLFDELTGKSKGYAIINYGDNETASSAVRNLNYMTLPNGRFLKCSFVTDYDMSSKESVKLPPLPLGIQIHPNQNASQVISTILSNIDSNSALQILKEIKVMSIDNPKSTKVLLERFPQLSLALVELGLLSNTTNQELIELTLNKRPVDLTELSLDHVRLLQSVEKLTDEEIDELDESQQEIVRKVKEEIAKGTYGEVSAVKDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF85</accession>
    <name>C4YF85_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin-conjugating enzyme E2-21 kDa 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_01197</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF85"/>
    <dbReference type="SMR" id="C4YF85"/>
    <dbReference type="PaxDb" id="5476-C4YF85"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01197"/>
    <dbReference type="HOGENOM" id="CLU_030988_7_1_1"/>
    <dbReference type="OMA" id="KFYVRFK"/>
    <dbReference type="OrthoDB" id="269518at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23797">
        <property type="entry name" value="UBCc_UBE2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000016">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="3"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ42971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="190" mass="21549" checksum="BBC13C4B5437816F" modified="2010-10-05" version="1">MTSPKRRIEKDVMELMMSDHDVTLIDDSIQQFFVIFHGPPDTPYEGGVWKIRVELPDQYPIKSPSIGFTNKIYHPNIDEGSGSVCLDVINQTWSPMFGLLNIFENFLPHLLRYANPSDPLNTEASNLMTKDEAKYNDTVKKYVQQYAKNNFDITGKDDNEDNDDDDDELSDVGSLSSDDDNEDVAGSMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFC3</accession>
    <name>C4YFC3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_01239</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFC3"/>
    <dbReference type="SMR" id="C4YFC3"/>
    <dbReference type="PaxDb" id="5476-C4YFC3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01239"/>
    <dbReference type="HOGENOM" id="CLU_167122_2_0_1"/>
    <dbReference type="OMA" id="GESDACM"/>
    <dbReference type="OrthoDB" id="278325at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000461">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1230.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018279">
        <property type="entry name" value="Ribosomal_eS21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002148">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00996">
        <property type="entry name" value="RIBOSOMAL_S21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ43009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="87" mass="9639" checksum="E744C3540B02A11C" modified="2009-07-28" version="1">MENDKGQLVELYVPRKCSATNRIIKAKDHASVQISIAKVDEDGRAIAGENITYALSGYVRGRGEADDSLNRLAQQDGLLKNVWSYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFQ8</accession>
    <name>C4YFQ8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein GMH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_00034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-50 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFQ8"/>
    <dbReference type="PaxDb" id="5476-C4YFQ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00034"/>
    <dbReference type="HOGENOM" id="CLU_066239_1_2_1"/>
    <dbReference type="OMA" id="YRNFMYR"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007881">
        <property type="entry name" value="UNC-50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841:SF6">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05216">
        <property type="entry name" value="UNC-50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ41847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="37653" checksum="773EC781094C6B15" modified="2010-10-05" version="1">MSKRGNYPYLSADMFPQNPNITTSSRITSTTSRTGSVISNQSSSIYIPRPTINYGYSSSSTLVSRLKNIKVMVKRLFKPKTLDFETAIWEIFHLIVNPKKMYRSHYYYKQQQHEQLGNGNSYTRDDPSFLILLTGFLSLSAIAWGLAYQPSFKEIIKLIVYMVLVDFYLTGIVISTVTWILVNRLFNPGVQFSSYNINYISWGFCFDIHCNSFLIIWCLLYVVQFILLPVIRIKHSIFALLVGNSLYFGSIGYYFVVSFYGYNSLPFISANFGNYSSFSSSANNNNKNNPARTLQLVVVAGILPILALGWLVTLLFRINVADSMVDIYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGD9</accession>
    <name>C4YGD9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YGD9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03115"/>
    <dbReference type="HOGENOM" id="CLU_253414_0_0_1"/>
    <dbReference type="OMA" id="NPYHLYI"/>
    <dbReference type="OrthoDB" id="4025819at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="550"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="747"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="806"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="832"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="890"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="917"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="941"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="981"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1138"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1154"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1202"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1229"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1252"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1270"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1305"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1339"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1386"/>
            <end position="1401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1437" mass="157015" checksum="B83E4A410523A311" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGN8</accession>
    <name>C4YGN8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="1">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_03218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.2.9" evidence="1"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGN8"/>
    <dbReference type="PaxDb" id="5476-C4YGN8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03218"/>
    <dbReference type="HOGENOM" id="CLU_033347_0_1_1"/>
    <dbReference type="OMA" id="KEWWNGV"/>
    <dbReference type="OrthoDB" id="10268103at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138:SF5">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="2">
        <location>
            <begin position="28"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="359" mass="40789" checksum="5B54D874D462EE3E" modified="2009-07-28" version="1">MITPIYLCRGAFSHYRRYISQSTHDPLKIAFFGSDNFSVASLNKLIQYQKKNPDKVDSVHVITRSLKPQGRYMKTVQDLPVGKFSSQQGLSIMRADTSQEIRQLSEQYLFNLVIAVSYGRLIPSTFIQHCKYGGLNVHPSLLPKYSGSSPLQYALLNDDKFTGCTVQTLHPTKFDHGDIIIQSSEILISDDDNSVSLFKKFGEIGGDLLVKSIDQGLFVNPTPIENNYTRSMAPKIPKAKSQVFWNKYSAREIKRLYDALGPIFTFLNVNVIRKRKQICEKQRVILSCVKEYQLTDSFEQLKEPGDFMLVEEGLLVKAKKGGVLVERIKMQAQEEESPEKFIGTYSKKVGPDMPKHFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGW1</accession>
    <name>C4YGW1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase S59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_03297</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="S59.002"/>
    <dbReference type="PaxDb" id="5476-C4YGW1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03297"/>
    <dbReference type="HOGENOM" id="CLU_005908_0_0_1"/>
    <dbReference type="OMA" id="PMGKGLN"/>
    <dbReference type="OrthoDB" id="3797628at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021967">
        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12110">
        <property type="entry name" value="Nup96"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="12">
        <location>
            <begin position="483"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="113"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="453"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="421"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ44993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1360" mass="149911" checksum="1E4E84D7029D00CB" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH40</accession>
    <name>C4YH40_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_03381</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YH40"/>
    <dbReference type="PaxDb" id="5476-C4YH40"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03381"/>
    <dbReference type="HOGENOM" id="CLU_011752_0_0_1"/>
    <dbReference type="OMA" id="RCERMIL"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000638">
        <property type="entry name" value="Transmembrane GTPase Fzo1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF0">
        <property type="entry name" value="SARCALUMENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="217"/>
            <end position="505"/>
        </location>
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        </location>
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        </location>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    <sequence length="874" mass="99340" checksum="AF1EB1170B55CB39" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHT1</accession>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
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                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
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                <person name="Quail M.A."/>
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                <person name="Sherlock G."/>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="172" mass="20352" checksum="70521B6541FFF24E" modified="2009-07-28" version="1">MSRLNEYQVIGRNLPTESIPEPKLFRMRIFAPNTVVAKSRYWYFLQKLHKVKKASGEIVSVNIISEAKPTKVKTFGIWLRYESRSGIHNMYKEYRDVTRVGAVETMYQDLAARHRARFRSIHILKVVELEKTDDVKRQYVKQFLTKDLKFPLPHRVQKSKKLFQATAPTTFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
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                <person name="Munro C.A."/>
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                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
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                <person name="Brunke S."/>
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                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
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                <person name="Sherlock G."/>
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                <person name="Silverstein K.A."/>
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                <person name="Staggs R."/>
                <person name="Stansfield I."/>
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                <person name="Zeng Q."/>
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                <person name="Berriman M."/>
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                <person name="Lorenz M.C."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
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        <location>
            <begin position="7"/>
            <end position="27"/>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="EEQ45360.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="23247" checksum="3DD95D69851B0992" modified="2009-07-28" version="1">MGTTRVGVSVVFRFFQFVANIGCFATSLHTDPLNTFILTVTVLNFIYNCYIWFGVPIMGMRAYHGILFSGEILFFLLYIGSSVYQLVYPYSYDWTANDSDNFSIDIRVVSCSLGFSCVGLYYITFIMYVCWGVIPASWHGFCKRFFERQPFRFGCIVFNDSNLDNESKNENVNCLEQTQNYPINNFEEKQSEIVNKDPIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI22</accession>
    <name>C4YI22_CANAW</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
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                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
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                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
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                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
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                <person name="Staggs R."/>
                <person name="Stansfield I."/>
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                <person name="Berriman M."/>
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                <person name="Lorenz M.C."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1524940_0_0_1"/>
    <dbReference type="OMA" id="ENNCTMA"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ45404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="176" mass="20292" checksum="4A1307135EE9F603" modified="2009-07-28" version="1">MEDRAIHTSPTRWLHHYSSTTDTANSGLQKVDTRWSNKTYFPKQAIQLESFEGDNLITQSKPSMFSRLLSKFRSIGKKEIVPPNYRSSSILSEKIHKNHSVSAFFPSTTSKETPYENIFSPSVDKPMDTIDTIQENNCTMAFIKHDCRTESNFFSSDFFRDSVRPVIDYDESEITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI55</accession>
    <name>C4YI55_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein MET17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_03763</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI55"/>
    <dbReference type="PaxDb" id="5476-C4YI55"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03763"/>
    <dbReference type="HOGENOM" id="CLU_018986_4_0_1"/>
    <dbReference type="OMA" id="NAFQIIQ"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071269">
        <property type="term" value="P:L-homocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000035">
        <property type="entry name" value="O-succinylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797">
        <property type="entry name" value="HOMOCYSTEINE/CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797:SF2">
        <property type="entry name" value="HOMOCYSTEINE_CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ45437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="339" mass="37017" checksum="4DF3851A501D6F93" modified="2009-07-28" version="1">MPSHFDTLQLHAGQPVEKPHQPRAPPIYATTSYVFNDSKHGAQLFGLETPGYIYSRIMNPTNDVFEQRIAALEGGIGALATSSGQSAQFLAIAGLAHAGDNIISTSYLYGGTYNQFKVAFKRLGIETKFVNGDAAEDFAKLIDDKTKAIYIETIGNPKYNVPDFEKITKLAHEHGIPVVVDNTFGAGGFLVNPIAHGADIVVHSATKWIGGHGTTIAGVIVDSGNFPWTEYPEKYPQFSKPSEGYHGLVLSDALGKAAYIGHLRIELLRDLGPALNPFGSFLLLQGLETLSLRVERQSENALKLAQWLEKNPNVESVSYLGLPSHESHELSKKYLNNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIB3</accession>
    <name>C4YIB3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycogen synthase kinase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_04185</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Protein kinase that acts downstream of the MPS1 MAPK cascade as a highly conservative signal modulator that dictates growth, conidiation and pathogenicity. Phosphorylates HAT1 at 'Ser-8' to block its translocation from the nucleus to the cytoplasm where HAT1 positively regulates appressorium development and pathogenicity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIB3"/>
    <dbReference type="SMR" id="C4YIB3"/>
    <dbReference type="PaxDb" id="5476-C4YIB3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04185"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_20_1"/>
    <dbReference type="OMA" id="MKTTMPM"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000009">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000082">
        <property type="entry name" value="Shaggy-related protein kinase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0309">Germination</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="25"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ45848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="409" mass="47289" checksum="E683C007BCCB8FDF" modified="2009-07-28" version="1">MSAKIELVTENVTNGHSGASETIQYTKSQMVGHGSFGVVFQIQLQPSNEIGAVKRVLQDKRFKNRELQIMKLVHHRNIADLKYYFYTNNEKNELYLNLILEFVPETLYKASHYYVSKRLNMPPLEVKLYTYQMFRALNYIHSQGICHRDIKPQNLLINPDTGELKLCDFGSAKILNPSEPNVSYICSRYYRAPELIFGATNYTTKIDVWSAGCVMAELILGQPLFPGESGIDQLVEIIKILGTPSREQIKNMNPNYMEHRFPQIKPIPLQKIFKKMSPDCIQFLIKVLQYSPIDRISCIEGLIDPYFDELRNENTKLPNYRKIFSQQFHSNNSSGFGNAANYQLYNSQPDLRDLPELFDFDDRELSVAPRLNKQLVPNWAYSHLRLNQHINSLDEFSPMSADELKVTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIC8</accession>
    <name>C4YIC8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIC8"/>
    <dbReference type="PaxDb" id="5476-C4YIC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04201"/>
    <dbReference type="HOGENOM" id="CLU_073356_0_0_1"/>
    <dbReference type="OMA" id="MCHLSTN"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="275" mass="31495" checksum="8931CDAD19C46D3E" modified="2009-07-28" version="1">MCHLSTNLQQLHLIANESGKIHSTTKMVAWPSSLNDFVFQNLNIDYRTLELLNLRESRLEKINIQKGDIKTLNADLFPASVKDLSLRGMGIQQLSDSFENLENLQKLSLAGNELRELTSVKLPMATLEFLDVRHCNLRFISPFLVSMIDEKNKKAKLRVEATGNWNVSVVDIRRALKASKGLSLYLSKLDEDLVEISKRSSRLHFNGELLDTYIKKPKTDDLYNGSDSNLDEQSDVGVMKSLSSEQFPVANQQRRNRNRNRNRKKQSFDVRTFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIE8</accession>
    <name>C4YIE8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIE8"/>
    <dbReference type="PaxDb" id="5476-C4YIE8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04221"/>
    <dbReference type="HOGENOM" id="CLU_152671_0_0_1"/>
    <dbReference type="OMA" id="LSIKLWQ"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="133" mass="15289" checksum="452F498F34B71C38" modified="2009-07-28" version="1">MLKLCKNHSKSFKVPFGGEQERKKERENGVIFFFSFASAPSFPLSLTFLSPFLSVSSRLNHHSLSFHSIPHSVPPHHHHHHLPPRSYFDSFPPFQPLSLSLFLSYSLHFLLLLSIKLWQPTKTKRITTQGIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIL9</accession>
    <name>C4YIL9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial</fullName>
            <ecNumber evidence="4">2.1.1.201</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ubiquinone biosynthesis methyltransferase COQ5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">COQ5</name>
        <name evidence="6" type="ORF">CAWG_04295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="EC" id="2.1.1.201"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.201" evidence="4"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIL9"/>
    <dbReference type="PaxDb" id="5476-C4YIL9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04295"/>
    <dbReference type="HOGENOM" id="CLU_037990_0_1_1"/>
    <dbReference type="OMA" id="MNDVMSM"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008425">
        <property type="term" value="F:2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000133">
        <property type="entry name" value="2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="4" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="175"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ45954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="306" mass="34317" checksum="52BF9FCA03707022" modified="2009-07-28" version="1">MIQNTVRRSILRSAKFTAPRSLLSISRSLTTENTPSKSTPPPKKDETTHFGFKTVNKDDKEKLVGGVFSSVASNYDVMNDVMSMGVHRLWKHHFIQRLDAGMRPGSTQPLEFLDVAGGTGDIAFGLLDHAEKKYGDIMSKMTIADINPDMLKEGEVRFAKTKWANTDRVNFLVQNGETMDQIPDNSKDVYTIAFGIRNFTDIQAGLNTAYRVLKPGGIFACLEFSQVENPLLDYAYQAYSFSLLPLMGQLIANDRDSYQYLVESIRKFPKQEEFKGMIEKAGFYVPEPGYENLTFGVASIHIGVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIP2</accession>
    <name>C4YIP2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIP2"/>
    <dbReference type="PaxDb" id="5476-C4YIP2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04318"/>
    <dbReference type="HOGENOM" id="CLU_012334_0_2_1"/>
    <dbReference type="OMA" id="SSYWTEH"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008142">
        <property type="term" value="F:oxysterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000010">
        <property type="entry name" value="Oxysterol-binding protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF184">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ45977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="48289" checksum="29A40EDB751B4D71" modified="2009-07-28" version="1">MSNSKSSSEETAKSSSWTSFLKSIASFNGDLSSLTAPPFILSPTSLVEYSQYWAEHPDLFIAPSLIKTTENPAKEEIEAINLQQMIAVTRWFISTLKSQYCSRNESMGSEKKPLNPFLGEVFVGKWQDDKTGETDLVSEQVSHHPPVTAYAIKNKKHGVVLQGYNGITSSISTTSINIKQYGHALLKYPEIDETFLITLPPLHIEGLITAAPFVELEGISYIQASSGHIAVIEYSGRGWISGKKNTFKARIYRDAYASASKENALVTISGQWSGKSYIGKGSSTPTSKNDVFYDASKTPTHHLQVKPIEEQHKLESRKAWFKVAEAIKKSDYNLIATEKTLIENEQRELRKQEKDAGITWETRWFDKIDYLNKDADAPIKDEFTNLTNISNLSIHNAPSGTLKDSKYDHGEAKHWRVNLKKLEDEKEIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIS9</accession>
    <name>C4YIS9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chromosome segregation in meiosis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_04356</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an important role in the control of DNA replication and the maintenance of replication fork stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the fork protection complex (FPC) consisting of TOF1 and CSM3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the CSM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ46014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIS9"/>
    <dbReference type="PaxDb" id="5476-C4YIS9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04356"/>
    <dbReference type="HOGENOM" id="CLU_068092_0_0_1"/>
    <dbReference type="OMA" id="ADMDDMW"/>
    <dbReference type="OrthoDB" id="437078at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012923">
        <property type="entry name" value="Csm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040038">
        <property type="entry name" value="TIPIN/Csm3/Swi3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220">
        <property type="entry name" value="TIMELESS INTERACTING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220:SF11">
        <property type="entry name" value="TIMELESS-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07962">
        <property type="entry name" value="Swi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation in meiosis protein 3" evidence="10">
        <location>
            <begin position="59"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="237"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ46014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="316" mass="35732" checksum="7195338FEC70791F" modified="2009-07-28" version="1">MSYVMDKTEEGINIDNTQHDLELDRDSSTQQPAQTHEDDGDLLGLDKPIKLKTRAKIAKVDNQRIFNHNGIPLLVKTHSKLLRTLKKNDKNFYSEPRSSISKSQKFEHEYENLSSVLQFYQLWCHGLFPKATFKDCIHLIRALGARSPQLRLYRRELIAAELHKLKVARGIITDENQDAPSIPEEENTTDPSNEEWNSMHMSALVPGSSNKNGLFVDSNSNEDFDTTNEVNAAASLADKDALSTDDKAEQTNAITSDTHNNDVDSDDPFSDDDDINIDAHTENLHPASGTQHQDRPKETTEENEDLELELMREYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIU7</accession>
    <name>C4YIU7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_04376</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ46032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIU7"/>
    <dbReference type="PaxDb" id="5476-C4YIU7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04376"/>
    <dbReference type="HOGENOM" id="CLU_285123_0_0_1"/>
    <dbReference type="OMA" id="PIEYCKM"/>
    <dbReference type="OrthoDB" id="6407164at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001712">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018835">
        <property type="entry name" value="RNA-binding_domain_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF8">
        <property type="entry name" value="RNA-BINDING PROTEIN MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10378">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="534"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="644"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="65"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="447"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="742"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="808"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1060"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="760"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="808"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="848"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="875"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="903"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1070"/>
            <end position="1087"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ46032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1087" mass="122192" checksum="80D1BE2BBCEF0728" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ45</accession>
    <name>C4YJ45_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acetyl-CoA C-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_03857</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ45"/>
    <dbReference type="PaxDb" id="5476-C4YJ45"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03857"/>
    <dbReference type="HOGENOM" id="CLU_031026_1_1_1"/>
    <dbReference type="OMA" id="DIIMGCV"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF9">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="8">
        <location>
            <begin position="9"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="9">
        <location>
            <begin position="271"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ45529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="41448" checksum="AF91C86E85CABD36" modified="2009-07-28" version="1">MFKKSANDIVVIAAKRTPITKSIKGGLSRLFPEEILYQVVKGTVSDSQVDLNLIDDVLVGTVLQTLGGQKASALAIKKIGFPIKTTVNTVNRQCASSAQAITYQAGSLRSGENQFAIAAGVESMTHDYFPHRGIPTRISESFLADASDEAKNVLMPMGITSENVATKYGISRKQQDEFALNSHLKADKATKSGHFAKEIIPIQTADENNQHVSITKDDGIRGSSTIEKLGGLKPVFKDDGTTTAGNSSQISDGGSAVILTTRQNAEKSGVKPIARFIGSSVAGVPSGLMGIGPSAAIPQLLSRLNVDTKDIDIFELNEAFASQSIYCIEKLGLDYDKVNPYGGAIALGHPLGATGARVTATLLNGLKGQNKELGVISMCTSTGQGYAALFANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJF7</accession>
    <name>C4YJF7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 15">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="11 15">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAWG_03970</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 15">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11 15"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJF7"/>
    <dbReference type="MEROPS" id="C19.A65"/>
    <dbReference type="PaxDb" id="5476-C4YJF7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03970"/>
    <dbReference type="HOGENOM" id="CLU_009884_1_0_1"/>
    <dbReference type="OMA" id="FVPCEHT"/>
    <dbReference type="OrthoDB" id="361536at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02658">
        <property type="entry name" value="Peptidase_C19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14385">
        <property type="entry name" value="UBA1_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14298">
        <property type="entry name" value="UBA2_scUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000118">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000396">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033864">
        <property type="entry name" value="UBA2_scUBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF664">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016308">
        <property type="entry name" value="UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11 15" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11 15" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10 11 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="19">
        <location>
            <begin position="162"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="18">
        <location>
            <begin position="312"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="17">
        <location>
            <begin position="581"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="17">
        <location>
            <begin position="651"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="629"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="634"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="748"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEQ45641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="795" mass="89783" checksum="35DD537BA185E89C" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJH9</accession>
    <name>C4YJH9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJH9"/>
    <dbReference type="PaxDb" id="5476-C4YJH9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03994"/>
    <dbReference type="HOGENOM" id="CLU_062048_0_0_1"/>
    <dbReference type="OMA" id="NWNVDMT"/>
    <dbReference type="OrthoDB" id="4097133at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="265" mass="29914" checksum="30CED111CD129D5A" modified="2009-07-28" version="1">MSDSEKEFTVEDTNVSDTELSKEERLEAARKKFEELKKKNKKKKSKKSKKSETTEIEDSAEGTPVPEDKPEDKSEEKAEDKSENKAEDKKDGDVKEDTKETKEKTTEETKTEKEDQPKVSEEAIPESSSSSSTSELEKQIEELKQTIEQQKSTIKKLRDENTDLKLSKMDLNDKISSLELENKNLKALTSSTSSVPGGSPIATYKETFKPAKPVFTKNDYASSSQQSFSKSNATEDFREKLMVWKGWQVDMTNWNGSGATQKVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJP1</accession>
    <name>C4YJP1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04059</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJP1"/>
    <dbReference type="PaxDb" id="5476-C4YJP1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04059"/>
    <dbReference type="HOGENOM" id="CLU_010412_4_1_1"/>
    <dbReference type="OMA" id="FCKDNAH"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF20">
        <property type="entry name" value="ZINC FINGER AN1-TYPE CONTAINING 2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="5">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="6">
        <location>
            <begin position="116"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ45725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="185" mass="20443" checksum="7B2822623EF0F82B" modified="2010-10-05" version="1">MKVTIRLSTESSFSVTIPDNATVDDLKQSIKVGLPADITLPPDFKVIYNGSKLQPYYAELQSFGMKSAEDNSYTVIVMSDNVDTPPITPQQSVESLAKSSTTTTTTTTTNATIKKTKKKSRCAFHNCNSAPLRMVGTCTHCQGKFCAKHRLLEDHMCTGLQYCKDNAHEKNAMKLQSERTIANRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJS1</accession>
    <name>C4YJS1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_04090</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJS1"/>
    <dbReference type="PaxDb" id="5476-C4YJS1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04090"/>
    <dbReference type="HOGENOM" id="CLU_048483_6_1_1"/>
    <dbReference type="OMA" id="CRFPMGW"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF134">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ45755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="292" mass="33497" checksum="2AE1AF765AE64F1B" modified="2010-10-05" version="1">MSLPIPTWETPFGIQLWPIFDFVASKLSQGKFVPSEFLFINGVTPLSTFPEAAVIIVIYYIVIFGGRFVISTLNLPVIKLNGLFQIHNLFLTSLSLTLLVLILEQIIPIFHSGGSYHSICSPNAYTSKLVVLYYLNYITKFIELIDTVFLVLRQKKLTFLHTYHHGATAWLCYTQLTGYTSVQWVPITLNLAVHVVMYWYYFLAARGIRVWWKEWVTRFQIIQFIIDLGVVYYSTFTHFVYKYSGKMRDCSGTETAAVVGCSILTSYLILFISFYITVYKKSGNASKKVKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJU3</accession>
    <name>C4YJU3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial inner membrane i-AAA protease complex subunit MGR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_04113</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJU3"/>
    <dbReference type="PaxDb" id="5476-C4YJU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04113"/>
    <dbReference type="HOGENOM" id="CLU_871878_0_0_1"/>
    <dbReference type="OMA" id="EFEMVWL"/>
    <dbReference type="OrthoDB" id="4087899at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013911">
        <property type="entry name" value="i-AAA_Mgr1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08602">
        <property type="entry name" value="Mgr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ45777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="41548" checksum="FFC240F2B45CE19E" modified="2009-07-28" version="1">MGVYIPPPNDKDDGDKKKQDTNSNTNQPTPPSSSSPSGSTTIYIPNPASLIPRNPKVGLIWGPLTPASDNLPALYSMIGLQFVIGCGFFKYARTLSRLRPIGGFQQQPHAHMAPKLVRTGPIWKIALSVITGSALSFGSGLELCRVTLPYDPWYDEAQHYRRMAVKNGDKPSSWFGAYRYYKPMDFKTWIDKVGDWIENVEKEIKIDDPANFANLSLELGKNSNVINVQRQPQTSGGILNKLNNKGKYLEIYTKLNENNTKRWEKLLHEDLNEVTELNKAPRLDLILEGKSDLINPEFTKSAIILGNHTMDDDDQFEMVWLNFEPWDELKLDTEYDIRLVPSYAGATEEIENEDQESPLTDNVVAKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJU6</accession>
    <name>C4YJU6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJU6"/>
    <dbReference type="PaxDb" id="5476-C4YJU6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04116"/>
    <dbReference type="HOGENOM" id="CLU_052364_0_0_1"/>
    <dbReference type="OMA" id="MFIREAT"/>
    <dbReference type="OrthoDB" id="4096888at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="424" mass="48100" checksum="934413F94118430A" modified="2009-07-28" version="1">MCPIDFEDEFSILTSPQPAISQSFASFTNVPIIHSTSTTVPSNNNARAQRRTSNFFPPTNDNSVLSTPNIQVSTDSYQFPDISCSTTTTAITESAMSPFTTFNKTALSEPPQSPFYVKTPSSMTTSNLGSPVINKLNQANFNAMNYQLTNSLHDLHLQSSLDSSLTSLAHQHQQQHMHDVYHNGNFHIRLPNISHQESIYNTEQHNILNQQNNYYERSQNHTQESENGFMLSTNSIDTPKLSPVLSQSIWNSEIIPELPKVEKRENRYSNKVNNPAFIPSEHPAEAKNASTDNNSQSPKNTTLDNDDIPPPQPQNQNIKFPKQVKYTPRHNHFVEDMLNHDLTNRYSEGYSTTFYKRNKHGYMFIREATNTLHVHQNSWVQLKIKLPTTSSTVTGNKNNSSSKKLLSKKLKVNIKELPIWKPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK27</accession>
    <name>C4YK27_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Catabolic 3-dehydroquinase</fullName>
            <shortName evidence="3">cDHQase</shortName>
            <ecNumber evidence="3">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">3-dehydroquinate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">DQD1</name>
        <name evidence="7" type="ORF">CAWG_05822</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Is involved in the catabolism of quinate. Allows the utilization of quinate as carbon source via the beta-ketoadipate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Aromatic compound metabolism; 3,4-dihydroxybenzoate biosynthesis; 3,4-dihydroxybenzoate from 3-dehydroquinate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homododecamer. Adopts a ring-like structure, composed of an arrangement of two hexameric rings stacked on top of one another.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="3"/>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK27"/>
    <dbReference type="SMR" id="C4YK27"/>
    <dbReference type="PaxDb" id="5476-C4YK27"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05822"/>
    <dbReference type="HOGENOM" id="CLU_090968_1_0_1"/>
    <dbReference type="OMA" id="VIECHIS"/>
    <dbReference type="OrthoDB" id="8191625at2759"/>
    <dbReference type="UniPathway" id="UPA00088">
        <property type="reaction ID" value="UER00178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046279">
        <property type="term" value="P:3,4-dihydroxybenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019631">
        <property type="term" value="P:quinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="entry name" value="Dehydroquinase, class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018509">
        <property type="entry name" value="DHquinase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01088">
        <property type="entry name" value="aroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003804">
        <property type="entry name" value="PRK05395.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003805">
        <property type="entry name" value="PRK05395.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003806">
        <property type="entry name" value="PRK05395.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003807">
        <property type="entry name" value="PRK05395.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="CATABOLIC 3-DEHYDROQUINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272:SF3">
        <property type="entry name" value="CATABOLIC 3-DEHYDROQUINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="Type II 3-dehydroquinate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01029">
        <property type="entry name" value="DEHYDROQUINASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 3" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3 4">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <begin position="105"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3 6">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ47256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="146" mass="16032" checksum="471929C1A72CD91E" modified="2010-10-05" version="1">MVKKVLLINGPNLNLLGTREPEKYGTTSLSDIEQAAIEQAKLKNNDSEVLAFQSNTEGFIIDRIHEAKRQGVGFVVINAGAYTHTSVGIRDALLGTAIPFIEVHITNVHQREPFRHQSYLSDKAVAVICGLGVYGYTAAIEYALNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK28</accession>
    <name>C4YK28_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_05823</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK28"/>
    <dbReference type="SMR" id="C4YK28"/>
    <dbReference type="PaxDb" id="5476-C4YK28"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05823"/>
    <dbReference type="HOGENOM" id="CLU_059021_3_0_1"/>
    <dbReference type="OMA" id="GNLIICE"/>
    <dbReference type="OrthoDB" id="10250990at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798:SF5">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798">
        <property type="entry name" value="FLAVOPROTEIN OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="6">
        <location>
            <begin position="137"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ47257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="339" mass="38197" checksum="B88746D38D40164D" modified="2010-10-05" version="1">MNRISSISGLTPNRFSQQVRSNKLREFPHFFISRQFITSSINHKSKMTNSQKPNEEPKRFGLENQVKRNPHPDFNKVENSRPPFDFENTWTYTQIPNKDWKVGSGANDPSWKDHKKLEIDPYGEGRNPVDNYKTLISAIVPRPIGFVSTVSKTGERNLAPFSYFTMVNHDPPIFTLGFSGGKGTPKDTCNNILETGELTINIISEWFVEAANYCSTNAPPGIDEWKLSGLTPLESAKVKPQHVAESAFSVEAKLVMSHEWKSKTDPNRATGVLCIVEGVNFHVREDVINSDLNNLDIGRLKPVSRLGGITYGRTVDGYERLRPDFGKESATNEVKQLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK72</accession>
    <name>C4YK72_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_05869</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK72"/>
    <dbReference type="PaxDb" id="5476-C4YK72"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05869"/>
    <dbReference type="HOGENOM" id="CLU_014123_0_0_1"/>
    <dbReference type="OMA" id="YQKCIKY"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF5">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="3">
        <location>
            <begin position="261"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ47301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="678" mass="77758" checksum="C5B9C3C73087E00A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKH6</accession>
    <name>C4YKH6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Polyprenal reductase</fullName>
            <ecNumber evidence="5">1.3.1.94</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_05980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol. Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a di-trans,poly-cis-dolichal + NADP(+) = a di-trans,poly-cis-polyprenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:80727"/>
            <dbReference type="Rhea" id="RHEA-COMP:19536"/>
            <dbReference type="Rhea" id="RHEA-COMP:19537"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:231623"/>
            <dbReference type="ChEBI" id="CHEBI:231637"/>
            <dbReference type="EC" id="1.3.1.94"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:80729"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the steroid 5-alpha reductase family. Polyprenal reductase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.94" evidence="5"/>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKH6"/>
    <dbReference type="PaxDb" id="5476-C4YKH6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05980"/>
    <dbReference type="HOGENOM" id="CLU_044409_0_0_1"/>
    <dbReference type="OMA" id="RFYETNF"/>
    <dbReference type="OrthoDB" id="541710at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003865">
        <property type="term" value="F:3-oxo-5-alpha-steroid 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160198">
        <property type="term" value="F:polyprenal reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102389">
        <property type="term" value="F:polyprenol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016095">
        <property type="term" value="P:polyprenol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039698">
        <property type="entry name" value="Dfg10/SRD5A3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624">
        <property type="entry name" value="DFG10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624:SF0">
        <property type="entry name" value="POLYPRENOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="151"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ47405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="282" mass="32600" checksum="7067057339AF196E" modified="2009-07-28" version="1">MAIYDSQLTVVALYSLIIIAIYSAKFITPLNELLQYGKTVSQDVREHARLENNLIKQTIGFISKYFVVPKAWFVHFYITLFALSSLIFLASFNEPISSDPEKFKNLILIHRLLWVQGIRRLTECLTITNFSKTSKMNVSHYVVGLSHYILVTWATYLGLSTYGSHQVPNNYTVFDIVLIIGFAICSLLQFQAHYHLSTLVKYTLPDFNFVSSPHYFYEILIYTILLSFAIKDGFDMVSVTFFTAWLFVISNLSISSLETFSYYQKKYKEEFKLKWAVLPGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKI0</accession>
    <name>C4YKI0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Stb3p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKI0"/>
    <dbReference type="PaxDb" id="5476-C4YKI0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05984"/>
    <dbReference type="HOGENOM" id="CLU_020170_0_0_1"/>
    <dbReference type="OMA" id="FAKIGWG"/>
    <dbReference type="OrthoDB" id="5391991at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000432">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018818">
        <property type="entry name" value="Stb3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28164">
        <property type="entry name" value="PROTEIN STB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28164:SF1">
        <property type="entry name" value="PROTEIN STB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10330">
        <property type="entry name" value="Stb3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="54844" checksum="F29B71E94429FB5A" modified="2010-10-05" version="1">MTSRSPISLASLMNDPTPPPQPQSQSQPRSQFPTTTTQTSMQQQSQEPSLQQSDSKKTLLSTSSPEGIQVASKITPTRLANLLIRKGPLPIRHITSQLALEVPSFELLSLSKQRRLIMAAMEQTDTVNNVVFEKIGWGQWAVRKIDSDYIVTEGTEKSSNANTSGSSGNGSANEKLINVNDLRNQSNLKLGWSKKKKSVSASAGAGSGAGLNSRRESITNHVKSLHNIKLPNESIDNAIASESSDDDDDDDQEGIDEYALSDTESSDEEMFAFDEKNRASSSVSNPITAISEHTVLGSPPIKFARRVPIKISPPPEVGAINGSGNMASSASRRRKSSSSVSNSITKPYRQHLFNTRSRLNSIENLDNYIVSSAKNSSVSISSPPPPISFSSSPATSVAYDEHYNLNQQQSSSFQQKLQQQQQQQKNQRRKSSFNESHVRSTLSNVKTSSDDTDEEDWAAMGPESLRKNRKNSIPAALRNDIDSSGVDEEEKSAAFALVDLMSV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-10-19" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKT4</accession>
    <accession>Q9UQX7</accession>
    <accession>Q9UVU4</accession>
    <name>RAS1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>Ras-like protein 1</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Ras homolog type B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RAS1</name>
        <name type="ORF">CAWG_06092</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2001" name="Mol. Microbiol." volume="42" first="673" last="687">
            <title>Ras links cellular morphogenesis to virulence by regulation of the MAP kinase and cAMP signalling pathways in the pathogenic fungus Candida albicans.</title>
            <authorList>
                <person name="Leberer E."/>
                <person name="Harcus D."/>
                <person name="Dignard D."/>
                <person name="Johnson L."/>
                <person name="Ushinsky S."/>
                <person name="Thomas D.Y."/>
                <person name="Schroeppel K."/>
            </authorList>
            <dbReference type="PubMed" id="11722734"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.2001.02672.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>VARIANTS ASN-216 INS AND GLN-SER-251 INS</scope>
        <scope>FUNCTION</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the regulation of both a MAP kinase signaling pathway and a cAMP signaling pathway. The activation of these pathways contributes to the pathogenicity of the cells through the induction of the morphological transition from the yeast to the polarized filamentous form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text>Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="AF134251">
        <property type="protein sequence ID" value="AAF03566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF134252">
        <property type="protein sequence ID" value="AAF03567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKT4"/>
    <dbReference type="SMR" id="C4YKT4"/>
    <dbReference type="PaxDb" id="5476-C4YKT4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06092"/>
    <dbReference type="HOGENOM" id="CLU_041217_9_0_1"/>
    <dbReference type="OMA" id="CEFTEAS"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="PHI-base" id="PHI:507"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-0636">Prenylation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000413060" description="Ras-like protein 1">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000413061" description="Removed in mature form" evidence="1">
        <location>
            <begin position="286"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Effector region">
        <location>
            <begin position="33"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="178"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="246"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="58"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="117"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Cysteine methyl ester" evidence="1">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-palmitoyl cysteine" evidence="1">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-farnesyl cysteine" evidence="1">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele A." evidence="4">
        <original>N</original>
        <variation>NN</variation>
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In allele B.">
        <original>S</original>
        <variation>SQS</variation>
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P01112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="11722734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="288" mass="32237" checksum="25A85F4B93D2DDBC" modified="2009-07-28" version="1" precursor="true">MLREYKLVVVGGGGVGKSALTIQLIQSHFVDEYDPTIEDSYRKQCTIDDQQVLLDVLDTAGQEEYSAMREQYMRTGEGFLLVYSINSLNSFQELNSFYDQILRVKDSDNVPVLVVGNKCDLEMERQVSYEDGLALANSFNCPFLETSAKQRINVEEAFYGLVRNINQYNAKIAEAEKQQQQQQQQQNANQQGQDQYGQQKDNQQSQFNNQINNNNNTSAVNGGVSSDGIIDQNGNGGVSSGQANLPNQSQSQRQQQQQQQEPQQQSENQFSGQKQSSSKSKNGCCVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKW5</accession>
    <name>C4YKW5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_06124</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKW5"/>
    <dbReference type="SMR" id="C4YKW5"/>
    <dbReference type="PaxDb" id="5476-C4YKW5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06124"/>
    <dbReference type="HOGENOM" id="CLU_060400_1_0_1"/>
    <dbReference type="OMA" id="GHIQLNL"/>
    <dbReference type="OrthoDB" id="1109245at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="9">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ47544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="262" mass="29364" checksum="66E2C9A11692BF9B" modified="2010-10-05" version="1">MGRGPKKHLKRLAAPSHWMLDKLSGTYAPRPSAGPHKLRESLPLVVFLRNRLKYALNGREVKAIMMQQHVQVDGKVRTDTTYPAGFMDVITLEATNEHFRLVYDVKGKFAVHRISAEEAAYKLGKVKKVQLGKKGVPYVVTHDGRTIRYPDPLIRANDTVKIDLATGKIDDFIKFDTGRLVMVTGGRNLGRVGVIVHREKHEGGFDLVHIKDALENTFVTRLSNVFVIGTEAGKPWVSLPKGKGIKLSISEERDRRRAQQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKX3</accession>
    <name>C4YKX3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 1A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 4C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_06132</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 9">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the eIF-1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKX3"/>
    <dbReference type="SMR" id="C4YKX3"/>
    <dbReference type="PaxDb" id="5476-C4YKX3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06132"/>
    <dbReference type="HOGENOM" id="CLU_109098_0_1_1"/>
    <dbReference type="OMA" id="RRVMMHA"/>
    <dbReference type="OrthoDB" id="274995at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000071">
        <property type="entry name" value="Eukaryotic translation initiation factor 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="11">
        <location>
            <begin position="24"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ47552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="154" mass="17376" checksum="4546298833966CF2" modified="2010-10-05" version="1">MGKSSGKGKGGKNRRRGKNVNSGQKRELIYKEEGQEYAQITKMLGNGRIEVSCFDGIKRMGHIRGKLRKKVWMGQGDIILVSLRDFQDDQCDVVHKYNSDEARTLKNVGELPENAKINETDTFGADDDEEVNFEFGGADEDESEEDEELDIDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKX7</accession>
    <name>C4YKX7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_06136</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKX7"/>
    <dbReference type="PaxDb" id="5476-C4YKX7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06136"/>
    <dbReference type="HOGENOM" id="CLU_011638_1_0_1"/>
    <dbReference type="OMA" id="GIYEMHK"/>
    <dbReference type="OrthoDB" id="2018507at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001480">
        <property type="entry name" value="Serine/threonine-protein kinase AKL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF65">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE AKL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="522"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="654"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="544"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="662"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="676"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="694"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="710"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ47556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="734" mass="81816" checksum="210E30A21A7A8CAD" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL00</accession>
    <name>C4YL00_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cation-transporting P-type ATPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_01514</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL00"/>
    <dbReference type="PaxDb" id="5476-C4YL00"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01514"/>
    <dbReference type="HOGENOM" id="CLU_002360_4_1_1"/>
    <dbReference type="OMA" id="FVNLVIC"/>
    <dbReference type="OrthoDB" id="158672at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000114">
        <property type="entry name" value="H /K ATPase alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="397"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="11">
        <location>
            <begin position="113"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ43281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="879" mass="96840" checksum="58CC782309BC6385" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL50</accession>
    <name>C4YL50_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_01565</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL50"/>
    <dbReference type="PaxDb" id="5476-C4YL50"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01565"/>
    <dbReference type="HOGENOM" id="CLU_010150_0_0_1"/>
    <dbReference type="OMA" id="LVWCVHE"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000003">
        <property type="entry name" value="C6 transcription factor (Leu3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF6">
        <property type="entry name" value="TRANSCRIPTION FACTOR SEF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
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                <person name="Lin M.F."/>
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                <person name="Sakthikumar S."/>
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                <person name="Grabherr M."/>
                <person name="Forche A."/>
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                <person name="Brunke S."/>
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                <person name="Hube B."/>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
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                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
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                <person name="Brunke S."/>
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    <dbReference type="GO" id="GO:0015031">
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR28199:SF1">
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    </dbReference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ43373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="15214" checksum="CFB7063EB5788708" modified="2009-07-28" version="1">MAAFDEIFDYVDRDTFFQYFRLTLVVCTYLIFRKYYSSWAIKRQTATQLEQDKREQSEKSEREAKESKEKFDTISNEAKEFGWGKKTRNNVKLTEAVLAEYSEQQRQRNQTSYDAQEDADIDDLLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLN7</accession>
    <name>C4YLN7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Adenylyl cyclase-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_01756</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CAP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLN7"/>
    <dbReference type="PaxDb" id="5476-C4YLN7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01756"/>
    <dbReference type="HOGENOM" id="CLU_015780_1_0_1"/>
    <dbReference type="OMA" id="KSQQTHK"/>
    <dbReference type="OrthoDB" id="77251at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.330:FF:000001">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.330">
        <property type="entry name" value="Adenylate cyclase-associated CAP, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013992">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018106">
        <property type="entry name" value="CAP_CS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053950">
        <property type="entry name" value="CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036222">
        <property type="entry name" value="CAP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF0">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21938">
        <property type="entry name" value="CAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01213">
        <property type="entry name" value="CAP_N-CM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101278">
        <property type="entry name" value="N-terminal domain of adenylylcyclase associated protein, CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01088">
        <property type="entry name" value="CAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="6">
        <location>
            <begin position="380"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="266"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="334"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ43518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="543" mass="59449" checksum="49309011F8EB130E" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLX4</accession>
    <name>C4YLX4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 14">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_01846</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLX4"/>
    <dbReference type="PaxDb" id="5476-C4YLX4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01846"/>
    <dbReference type="HOGENOM" id="CLU_1209709_0_0_1"/>
    <dbReference type="OMA" id="PKIAKHT"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="15"/>
            <end position="39"/>
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            <begin position="51"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="14">
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            <begin position="77"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
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            <begin position="174"/>
            <end position="194"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
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    <sequence length="237" mass="27732" checksum="D16745F8FD57D878" modified="2009-07-28" version="1">MASLYPLKFNEKLAFFYNTVAATLWFCCLGRFLILLPLVGRKFLPGGMADFFHVVSLLPIIESLFVKSVLRKKFTITSLWGISNGLKMVWLCYGVIFPHPKIAKHTSYSLLITSWCLQNFIHYFYYAFKVKTKSSFHFLFWLEYNNFYLTYPLGLVSEMILLFLSLAFVEQDSIYDYVLRAAFLAYIPIAYFAWGHLKSRKKKRYTEIMNKRNVRQVATLESTTTGTKNTSIELRNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
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                <person name="Sherlock G."/>
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                <person name="Berriman M."/>
                <person name="Heitman J."/>
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                <person name="Lorenz M.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="671" mass="75446" checksum="CE61D9D241732F75" modified="2009-07-28" version="1"> </sequence>
</entry>
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                <person name="Santos M.A."/>
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                <person name="Munro C.A."/>
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                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
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                <person name="de Groot P.W."/>
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                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
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                <person name="Santos M.C."/>
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                <person name="Sherlock G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <dbReference type="OMA" id="EPEEINC"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="192"/>
        </location>
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    </feature>
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        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN34</accession>
    <name>C4YN34_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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            <taxon>Candida</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
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                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
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                <person name="Quail M.A."/>
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                <person name="Silverstein K.A."/>
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                <person name="Srikantha T."/>
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                <person name="Berriman M."/>
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                <person name="Lorenz M.C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02274"/>
    <dbReference type="HOGENOM" id="CLU_110348_0_0_1"/>
    <dbReference type="OMA" id="YCIGTKD"/>
    <dbReference type="OrthoDB" id="1894652at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21203">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27615" checksum="8D16A7579C3A82E5" modified="2010-10-05" version="1">MGMDKKKNVGFGFQNSTHEYLANHFKLHQMFIPGFLTLLLTILASVEAKKINLYIKPIDSPSKGDSIGFINDDSVYLIDSTTTLQPDQFYCVGTKDLDNHECFTLINGVESLNGTVIDAFMDENGVTISRLSLNFDESYNNKSKLRKHKFTTSPIPNLNPDSLKKQRQKQGNKGGQGNNKQVEIIKQKKLVKYIDDDGNEAEKEIEEEIVVEVDNRSWVQKNWMYIVPPLLLFLIVGGGDQPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN56</accession>
    <name>C4YN56_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit J</fullName>
            <shortName evidence="4">eIF3j</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 30 kDa subunit homolog</fullName>
            <shortName evidence="4">eIF-3 30 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">HCR1</name>
        <name evidence="6" type="ORF">CAWG_02296</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit J family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN56"/>
    <dbReference type="SMR" id="C4YN56"/>
    <dbReference type="PaxDb" id="5476-C4YN56"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02296"/>
    <dbReference type="HOGENOM" id="CLU_085412_0_0_1"/>
    <dbReference type="OMA" id="KPHYALW"/>
    <dbReference type="OrthoDB" id="20381at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.60">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03009">
        <property type="entry name" value="eIF3j"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023194">
        <property type="entry name" value="eIF3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="232"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ44037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="285" mass="32047" checksum="8DB6F540AB43E288" modified="2009-07-28" version="1">MSWDDEDFDIPSNSKKTVAASWEDEEDDGPVLESWDVDPEEEEKKKKEAKLQEAKRKAELKAKEDAEKAKKDAKRKELEQFDQLDERTRKELLKKAELNADLNNAADLFGGLGVADDNDDDDFDINEHPRERITKQQLAAAAASKRPALTKDTPLEEHPLFQPTNKQEYEKLRKTVGTSLTRLNEDSSLLYASSLAVDLIRDLSQPLSVENLRKVISTLNVVIKDKERQERQARLKKAGGTATGGAGKKKAKPLARPNVGGGFKKDAFDDMDDGQFDDLDDDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNT7</accession>
    <name>C4YNT7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Acetate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_02870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNT7"/>
    <dbReference type="SMR" id="C4YNT7"/>
    <dbReference type="PaxDb" id="5476-C4YNT7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02870"/>
    <dbReference type="HOGENOM" id="CLU_051062_0_0_1"/>
    <dbReference type="OMA" id="IYLWAWF"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ44596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="30639" checksum="5E4A084A3165BAB6" modified="2010-10-05" version="1">MSSLESISSELKAVPIADEIENVVLPYKTCTITGEGNEFVVIGDHKYYRHELMQAFGGTFNPGLAPYPKHSFGNPAAIGLVSTGMNILIFGLFFAHAMGIHIPNAGIGLCMFMGGLVEILAGIWGFFVGSQVGTFVLTVFTSYGAFWLSFGAIFIPSFGIIQAYEEDPEQLNHAIGLMLIGWAIFTTMLLMCVVKSTLSFFWALLTYDLTIILFAAGFLSDNDKVKVAGGIMGVINAFADWFEAFAGVANRQNSYMVPREIPLPDLSVWLKRKKAVSKTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNT9</accession>
    <name>C4YNT9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_02872</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNT9"/>
    <dbReference type="PaxDb" id="5476-C4YNT9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02872"/>
    <dbReference type="HOGENOM" id="CLU_051062_0_0_1"/>
    <dbReference type="OMA" id="INTFAGW"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ44598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="280" mass="30403" checksum="66F8030E26E26717" modified="2009-07-28" version="1">MSSSASITSDIKALEASSEIENVEPYKTCTITGDGNEFVVIGDHKYYRHELMQAFGGTFNPGLAPYPKHSYGNPAAIGLVATSMNIFILGLFFAHAMGIHAPNVAVGLFVFMGGVVQFLVGIWGFFIGSQVGTFIFIVFTSYGAFWLSFGAIFIPAFGIGEAYAEHPEQLNQGIGLMSVGWAIFTTMLVLCVMKSTLSFFWALFTLDLTIILLAAGFLLDSDKVKIAGGIMGVINTFAGWFEAFAGVANTHNSYLVPKEIPLPDLSLWFKRKKSENQPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNV4</accession>
    <name>C4YNV4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bacterial surface antigen (D15) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_02887</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNV4"/>
    <dbReference type="PaxDb" id="5476-C4YNV4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02887"/>
    <dbReference type="HOGENOM" id="CLU_014798_3_1_1"/>
    <dbReference type="OMA" id="KHPVARF"/>
    <dbReference type="OrthoDB" id="1724197at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="7">
        <location>
            <begin position="179"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ44613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="507" mass="58073" checksum="FCD58B063A1EFBDA" modified="2009-07-28" version="1">MSLDNEHDQFMDNLKPAVPSSSSSLSSSDLSQAEKELNQLQQDKQNLMIQQNQQYLESLFQDHKHQPIKIRNVQITNGQLYRDEFLKYQFRNLLNGEIMSLGNYVKNVNQISKDLINSGIIDNLQVVNNLVNPPMFSKSQAYHVVPVFNIVPSKRFFAKTGTNIGNGEGDGYIQFQFKNLFGGGENLIFDAITGTKTKSSYLLNYNQPIGNNLQYMNENLLLINTRNLDWLQSNVTTRGMINKLYTRFHGDITCLNHEVILENSWKILNNHQSKSMQVLQQSGSQFKSSISYNLNYDTRDNKHLPTKGKFFQIGLEYNDPSILFFKLKNQYPFIKTVTQSQFIHRFPFINSNLIITNKFGLLYPLTKDKNSSLLDRFYIGGPNDVRSFLLNGLGPKDYNSCIGGDLFLNGGISLITDIPKYNESNFKIHNFINFGRLVGFNKDISLFNNLQNLNLTLTSQYSISYGFGILFNHPMARFELNFVLPLVTHERDSLRKGIQYGIGVSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP80</accession>
    <name>C4YP80_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Beta-mannosyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_03026</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BMT family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YP80"/>
    <dbReference type="PaxDb" id="5476-C4YP80"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03026"/>
    <dbReference type="HOGENOM" id="CLU_013841_1_1_1"/>
    <dbReference type="OMA" id="DWKGPED"/>
    <dbReference type="OrthoDB" id="3631276at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021988">
        <property type="entry name" value="BMT1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12141">
        <property type="entry name" value="BMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ44739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="695" mass="80961" checksum="0D09456B0A96828F" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP97</accession>
    <name>C4YP97_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YP97"/>
    <dbReference type="PaxDb" id="5476-C4YP97"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03046"/>
    <dbReference type="HOGENOM" id="CLU_1408556_0_0_1"/>
    <dbReference type="OMA" id="GDENQHY"/>
    <dbReference type="OrthoDB" id="4013061at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="193" mass="21663" checksum="8D92C0010B4DFAEA" modified="2009-07-28" version="1">MSSSPKDILPLTHRPFGDENQHYVDHPEPELLATSVGKEVDGRLIPSSSTISLLSLNQSPSLRNSTTTSYTNLQHLQRMQPYHNQKVTASPADYTHSFSTSRFIPIQQQPTPDSPNLAPISLGSSPSRFWLSSPPKSMNRIGDEPVIRPVQTPLEEPPMTPLYLNRPNVTRSDYFSRVSTVSEEEERRSMGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPA0</accession>
    <name>C4YPA0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.205</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2'-O-ribose RNA methyltransferase TRM7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_03049</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42396"/>
            <dbReference type="Rhea" id="RHEA-COMP:10246"/>
            <dbReference type="Rhea" id="RHEA-COMP:10247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.205"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.205" evidence="7"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPA0"/>
    <dbReference type="SMR" id="C4YPA0"/>
    <dbReference type="PaxDb" id="5476-C4YPA0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03049"/>
    <dbReference type="HOGENOM" id="CLU_009422_1_2_1"/>
    <dbReference type="OMA" id="FIVCLNF"/>
    <dbReference type="OrthoDB" id="289250at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106340">
        <property type="term" value="F:tRNA (guanosine(34)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000176">
        <property type="entry name" value="tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03162">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028590">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="8">
        <location>
            <begin position="21"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ44759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="293" mass="32760" checksum="652E35B4DAE1BCD4" modified="2010-10-05" version="1">MGKASKDKRDLYYRRAKEEGWRARSAFKLLQLNEEFNLFKDITRVVDLCAAPGSWSQVLSQKLGPDSTIVAVDLQPMTPIDGVTTIQADITHPKTLQRIRDCFGGEPADFVCSDGAPDVTGLHDLDEYIQSQLILSALQLTTCLLKPGGSFVAKIFRGRDIDLLYSQLSYLFDKVICAKPRSSRGTSLEAFIVCLGYKPRPGWKPTLDLTKSTEEFFEGADIGKQTTTQILEYSEEERKIAPFIACGDINDIDSDATYSLDLSTLTLDPVQKPTAPPYKKALEMKRRGDLHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPB8</accession>
    <name>C4YPB8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_03071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
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                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
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    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_395326_0_0_1"/>
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    <dbReference type="OrthoDB" id="4017072at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ44777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="626" mass="73127" checksum="198DD69DDC606AC4" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPE5</accession>
    <name>C4YPE5_CANAW</name>
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        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">CAWG_03098</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
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                <person name="Hube B."/>
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                <person name="Kodira C."/>
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                <person name="Neiman A.M."/>
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                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
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                <person name="Silverstein K.A."/>
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                <person name="Lorenz M.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ44805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="105" mass="10934" checksum="6462951546A27DC1" modified="2009-07-28" version="1">MSAHATTSSPLLSCIDTYCAVSPLPTSNPGTLSWIVFPAASLPTRETNLVSSQTYPLALAILYPTPPIEFVTVPIFESPILVLGPSLAIVSSATDPTTKTDASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
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            <taxon>Saccharomycotina</taxon>
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            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
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    </organism>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
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                <person name="Hoyer L.L."/>
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                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
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                <person name="Quail M.A."/>
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                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
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                <person name="Staggs R."/>
                <person name="Stansfield I."/>
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                <person name="Lorenz M.C."/>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
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    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
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        <property type="match status" value="1"/>
    </dbReference>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22858" checksum="8512DD2CCFC27806" modified="2009-07-28" version="1">MSDSTLSKISELIKLEDDLAKIGSIRQQFLKEKSSVDVKLSSTTQVQIDSIMKNLANLHNTMERLDSIKGSIGEVQQVHDSTIGEVREYDTIKKMTMVNQFLHQVGSLYEDISGFKRFVGALNEEIQRELQGLQNDLKYPLPNFVRIHHAYTQARNFVDYLEVYSTRLSDDLQSIVYKVVSPIKTTIKLFDELLNEGIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
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            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
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                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
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                <person name="Staggs R."/>
                <person name="Stansfield I."/>
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                <person name="Berriman M."/>
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                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">WO-1</strain>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="178" mass="18814" checksum="1194A810B30933DD" modified="2010-10-05" version="1">MVACFDDGVNTAAFGFNLYVFGSFLVWSCCFFKISSCFILSLAKIGNKSCGILCGILKLALNSRNELISLCAFNLNDSFGTGGFGGIDSGFACFELDTIAGSWWWCVVVPCCAGFEISAFLNAAINSSPLLSTPEYLSSSSTPLSSTTTPLSSKMCRSVVACCSISLAILSALATRSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ12</accession>
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            <taxon>Eukaryota</taxon>
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            <taxon>Candida</taxon>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
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                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
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                <person name="Schmitzberger F.F."/>
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                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
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                <person name="Stansfield I."/>
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                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
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                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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                <person name="Cuomo C.A."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ12"/>
    <dbReference type="PaxDb" id="5476-C4YQ12"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02566"/>
    <dbReference type="HOGENOM" id="CLU_018775_0_0_1"/>
    <dbReference type="OMA" id="PYYNFIN"/>
    <dbReference type="OrthoDB" id="4015271at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="794"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="794"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="875" mass="104290" checksum="E7DCD2A4CC90E8D7" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ82</accession>
    <name>C4YQ82_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ82"/>
    <dbReference type="PaxDb" id="5476-C4YQ82"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02638"/>
    <dbReference type="HOGENOM" id="CLU_011226_15_7_1"/>
    <dbReference type="OrthoDB" id="2098326at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="140" mass="16165" checksum="7AA0CAEF4C69D367" modified="2010-10-05" version="1">MALLINSVAKHVAPFATKAVVKIITKAINNGYYKHEWYLNFQYLEDRLAQNGTGFFVGNKLTGADVILSFPVYENVFDNPGGVREICGEKRDLRKVYPHLAKWSRMIKNNPTYKRVTEMMNEEVEDLIAMNPRFDYGKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ97</accession>
    <name>C4YQ97_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VPS37 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_02653</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ97"/>
    <dbReference type="PaxDb" id="5476-C4YQ97"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02653"/>
    <dbReference type="HOGENOM" id="CLU_1518435_0_0_1"/>
    <dbReference type="OMA" id="LYRWEEE"/>
    <dbReference type="OrthoDB" id="10260857at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="7">
        <location>
            <begin position="111"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ44386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="199" mass="23626" checksum="65EEFD30852ED461" modified="2009-07-28" version="1">MTEIHLDQTSQKIPDPVKFVSIEELHAFPLPKALESLPPSVFQQFLESKDLLQGYLKQLKAYQEKQSEIIDQLGELDNILENVIHKQLIKDYAALVDKINQQIKSINIIYQEFLNLETYQYQLLSNNFNQDILKLKFKKLLEKTNQDSLNIVKNYHEKGESTDDDFNNMIENFKESRKLYHSRKEKLYRWEEERVSGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQA7</accession>
    <name>C4YQA7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase small domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_02663</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQA7"/>
    <dbReference type="SMR" id="C4YQA7"/>
    <dbReference type="PaxDb" id="5476-C4YQA7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02663"/>
    <dbReference type="HOGENOM" id="CLU_018398_6_0_1"/>
    <dbReference type="OMA" id="DVNRNAC"/>
    <dbReference type="OrthoDB" id="406152at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000345">
        <property type="entry name" value="S-adenosylmethionine-dependent methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004557">
        <property type="entry name" value="PrmC-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00537">
        <property type="entry name" value="hemK_rel_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase small" evidence="5">
        <location>
            <begin position="47"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ44396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="221" mass="24631" checksum="891DB5876BC757C5" modified="2009-07-28" version="1">MLPTPTVKNIDYDEVYEPSEDSFLLLDCFEKEKDYLQSKFKTVVPLVTEIGTGSGIVTTFVAKHIVPNGIFLTTDINPHACETVLQTVKHNNDIGSSNCLLDSTQMDLTSAIKEREVDLLIFNPPYVPSSEIPEIPRTNNDPVWLDLALVGGEDGMVITWKVLNNLTNVLSKSGVAYILFCARNKPETVTSIMQSKGWNVEVVINRKAGWEVLSVLKFTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQJ7</accession>
    <name>C4YQJ7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQJ7"/>
    <dbReference type="PaxDb" id="5476-C4YQJ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02756"/>
    <dbReference type="HOGENOM" id="CLU_005049_0_3_1"/>
    <dbReference type="OMA" id="EMIPFIW"/>
    <dbReference type="OrthoDB" id="3162439at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="393" mass="45445" checksum="8E3E89327FFE2F9C" modified="2009-07-28" version="1">MIELLGLVNSGLEDMAPLAWRIYTSWEYAGQPVIHSENKTSTMAKEFKEIFFSYRCKSAFYGGCGDSVNSVGILWDRMFPYTIKTANVDHIRHAISIDEKRSKYKQQLFSPIESSDVGSKGSNTYSSPISYGSFTSVRSLVDILKRFVERFNRRKSRPLPAINDLIEVYFPGNHGDIGGGWKASSDNQVLSSVSLRWMLAHAIKYGVRFQPQSISQWSSDHPPISSFLSPNHDILSFSSKSPDSRSDIVLPEFPIKLFAGRGEESFLYVLFWWILELIPFLRITEIQEDGYWKRAFVPNLGKHRVLPSTSLFHWSVFYRLHYAADYNPKNLHNLSLGEKFIESLMQFKIFKFNEIYSYSENLTVKKIKNDWTPRFWKKVPDELSEYLEKDANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQL2</accession>
    <name>C4YQL2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_02771</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQL2"/>
    <dbReference type="PaxDb" id="5476-C4YQL2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02771"/>
    <dbReference type="HOGENOM" id="CLU_036916_0_0_1"/>
    <dbReference type="OMA" id="IFPVNCA"/>
    <dbReference type="OrthoDB" id="9439903at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002194">
        <property type="entry name" value="STP1p Transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051643">
        <property type="entry name" value="Transcr_Reg_ZincFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24396:SF19">
        <property type="entry name" value="FI01119P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24396">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="204"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="230"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ44501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="435" mass="49036" checksum="32D0DF34AE370631" modified="2009-07-28" version="1">MLILSIGLIHHTSNKSLYTISPNKGKRYEPFTTTSLGNFQFHVVRFLHRLIYGTQRYQELFPPIQKIKNINNVKQQRIFPVNCAADDLDLGFGESDQIELFNHPSKDTYGQFNLIQLIDIFDPPQVHAPSSADEFFKSNKDSEHIDIFDMITRQPPPFHQHQLNIETPYFEDFATPLVLPPHEVSSDDVESYFSGSVSTVSSIEPLDDEFVPPPQPPRTHTSRKRKHDSISPPASSDSSSSSYVPQLIPSSSSSVTSNGDSPVSPTTKRKYTKKKQPVFSNVDEPIVITTTTKTNNIDVKKITTTKNGTVENRFDCPSCDASFKVKGYLTRHLKKHSTSKAFECPFFDNHGVHGSKCHPTGGFSRRDTFKVHLRALHFIYPAGVKASQRNSFSGRCAGCFQYFDNNSEWLENHIEAGKCTGTVQYKQNVSNLLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQU1</accession>
    <name>C4YQU1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DOA4-independent degradation protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="SMR" id="C4YQU1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04438"/>
    <dbReference type="HOGENOM" id="CLU_069208_1_0_1"/>
    <dbReference type="OMA" id="KMAKMNQ"/>
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    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="235" mass="26443" checksum="4BCBFE19C55CD81A" modified="2010-10-05" version="1">MSQLFEWAFGKKLTPQERLRKNQRALEKTQRELSREITKLQQQEKKLISDIKKSAKSGQISSAKIQAKDLIRTKSYVSKFTSMKTQLQAISLRIQSVRSNQQMAMSMRDATRVLGGMNRSMNLPQLSRIAQEFAKESDMMDQKQEFMDDAIDDAMAMDEDELGEEEQVDEILSKVLDEIGVDLNTTLKDTPTGINAGNIEQADRARVAEAVGANGASSHDADEDDLQARLDSLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR28</accession>
    <name>C4YR28_CANAW</name>
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        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04527</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04527"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="prtT"/>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF6">
        <property type="entry name" value="TRANSCRIPTION FACTOR SEF1-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="26"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ46181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="661" mass="77412" checksum="A9CEF720AE68E342" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRB1</accession>
    <name>C4YRB1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ataxin-10 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Copper transport protein 86</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_04610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a role in the regulation of cytokinesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ataxin-10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRB1"/>
    <dbReference type="PaxDb" id="5476-C4YRB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04610"/>
    <dbReference type="HOGENOM" id="CLU_043683_0_0_1"/>
    <dbReference type="OMA" id="HFLFRQF"/>
    <dbReference type="OrthoDB" id="379794at2759"/>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051374">
        <property type="entry name" value="Ataxin-10/CTR86_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255:SF0">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ataxin-10" evidence="7">
        <location>
            <begin position="364"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ46264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="463" mass="54108" checksum="CEECEA0F98FA488C" modified="2009-07-28" version="1">MTDIDIDTIINRSLYALENSEYSEFDLLLNQLSYLIKQSVDSNNKTASKEQITRILDYTPNSFNQVESLRLYRGLLILVRNFAPLLDIDLFPIVANSFEKFLKALNQTSDWTDRIIEVYWQILANFQRNEFIEVTNELFGQWECKYKWKDIPVSVMSPVIHFLFRQFNTQDPHITNENLLSLLKLFETNHVMNAVYEIFTMIDFADTNNIGHDNKMFIHLLYDIITHESFQKWIEQQNEEETITKWLSLTSVIVQTKTDWNNYELIAFLSWNGSLFMKYAPLINSNRNTTVNGEDDLGYVEDDISAIIAIFAELSQFNATKQYFEHYEDLLPKLIFVFKWIHDNIEPITIKSSKIEEVGRYSSVKTNIITILSYLSYDSFQFQEKIRELGGLSLVLSNCIIDNNNPFIKEQAIVCLKYLLQKNPKNQQFVADLEAKKVVDDQVLSEVGYQVEVIDGKVAVKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRD9</accession>
    <name>C4YRD9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_04638</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRD9"/>
    <dbReference type="PaxDb" id="5476-C4YRD9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04638"/>
    <dbReference type="HOGENOM" id="CLU_006533_2_0_1"/>
    <dbReference type="OMA" id="MERCAQD"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF37">
        <property type="entry name" value="ABC1 FAMILY PROTEIN C10F6.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="175"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ46292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="439" mass="51213" checksum="DC7CF7BD09E5530E" modified="2009-07-28" version="1">MFRQSLIYINRPKKSVKSIYFHRYMNTKIPITSFKPIPTPIKPKPKPKPKPKLKFKLKPQGKFRPLVYGVAIVATGLGTAYYIDNHYYSSLMTRSVRAVYVLLWIAYAYGFNSNSYQNIDDLHEIASDKLLHLLTTNKGLYIKLGQAIANQGNLFPLAYQKKFPQLYDQAPVQSWQDVDRILKENLGDDYQIRLFETINHEPIASASIAQVHYGKLKNGEEVAIKVQHGYIEKQVVVDLMIYRFISKVYEKVFDIPLSMFMKYISEQLIKETDFVHEMQNSEKLKKFIDKDSSLKYDNIKLPKNYPHLTTKQVLTAEWINGIPLTNKQTLLDQNYDLTLIMKQYIKLFGRQIFEYGFIHSDPHPGNLLVRFDSKNKQQLVLIDHGLYITLSDSFRLQYCNLWRYLFSLNTKGIEQIGREWGISSTLLFGTVVQLRPRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRZ1</accession>
    <name>C4YRZ1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_04849</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRZ1"/>
    <dbReference type="PaxDb" id="5476-C4YRZ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04849"/>
    <dbReference type="HOGENOM" id="CLU_015115_0_0_1"/>
    <dbReference type="OMA" id="NTFALYP"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="7">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="219"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="564"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="574"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="610"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="640"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="663"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="707"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ46494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="718" mass="78701" checksum="C43852796DE39BBB" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS92</accession>
    <name>C4YS92_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 1</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">E2 ubiquitin-conjugating enzyme 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_04951</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS92"/>
    <dbReference type="PaxDb" id="5476-C4YS92"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04951"/>
    <dbReference type="HOGENOM" id="CLU_030988_13_1_1"/>
    <dbReference type="OMA" id="HWTFVYA"/>
    <dbReference type="OrthoDB" id="9993688at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14311">
        <property type="entry name" value="UBA_II_E2_UBC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23800">
        <property type="entry name" value="UBCc_UBE2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000080">
        <property type="entry name" value="UBC1p Ubiquitin-conjugating enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000037">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015368">
        <property type="entry name" value="UBA_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09288">
        <property type="entry name" value="UBA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="2"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ46595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="228" mass="25168" checksum="D7C42BB01E64C699" modified="2009-07-28" version="1">MSRVKRIAKELEECRQDTQSGVSLNLNNENDLTHLTGYFKGPPGTPYEGGLFQVAIDIPQEYPFKPPQMKFITKIYHPNISSVTGAICLDILKDAWTPILTLKSSLISLQSLLQSPEPSDPQDAEVAKHYLSNKSGFEETAAYWTKIYASDGVDGSGSSNNNGGGAKLSDSALYGIDDEIVGQYESMGFPRDKTIQVLRRMGIKSFKGVGNKSELENKILEELLRECQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS96</accession>
    <name>C4YS96_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alanine--glyoxylate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_04957</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.44" evidence="3"/>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS96"/>
    <dbReference type="PaxDb" id="5476-C4YS96"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04957"/>
    <dbReference type="HOGENOM" id="CLU_027686_5_2_1"/>
    <dbReference type="OMA" id="YEWDTPA"/>
    <dbReference type="OrthoDB" id="7403325at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004760">
        <property type="term" value="F:L-serine-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019265">
        <property type="term" value="P:glycine biosynthetic process, by transamination of glyoxylate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000049">
        <property type="entry name" value="Alanine-glyoxylate aminotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000027">
        <property type="entry name" value="Serine--pyruvate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152:SF24">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152">
        <property type="entry name" value="AMINOTRANSFERASE CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="11">
        <location>
            <begin position="78"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ46599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="425" mass="46497" checksum="8E6A985D6D36E1B3" modified="2009-07-28" version="1">MFKTLTTSKVIINKFNYKLIKPISLTNFKSISTTTTNLFNTNNNKMSFQYKQPEHKLTLIPGPIEFSDDVLASMATPSQAHTSPEFISTFQSVLKSLRKVFKSTDTNTQGYVLSGSGTLGWDVASSNLLNPDEKVLVLSTGFFSDSFAECLKVYGADVDVLTAEVGDVVPLDKIEQQLQKEKYSAITITHVDTSTSVVSDVEAISKVVKKVSPDILIIVDGVCSIAVEDLEFDKWGIDFALTASQKAIGVPAGLSIFYASERALAKALNKEKESTFFASLKRWTPIMKAYESGNGAYFATPAVQTITALKTSLDEILSQPIDERFAKHAQVSDKFKSNVEKLGLKILPVDHKVAAHGLTAVYFPDGINGPDLLKKLSEKGFVVAGGIHKKLVGKYFRVGHMGYSVYAGHVDKLTKALEESLNELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSC8</accession>
    <name>C4YSC8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MoaB/Mog domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSC8"/>
    <dbReference type="PaxDb" id="5476-C4YSC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04991"/>
    <dbReference type="HOGENOM" id="CLU_030805_0_0_1"/>
    <dbReference type="OMA" id="MARMPRG"/>
    <dbReference type="OrthoDB" id="448496at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047884">
        <property type="term" value="F:FAD diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042726">
        <property type="term" value="P:flavin-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675:SF1">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="1">
        <location>
            <begin position="32"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="316" mass="35809" checksum="23EBB40A491164CE" modified="2009-07-28" version="1">MGVSRRYLYHTLSRMTQLTATTIKNKPIRNAGCLIIGDEILNGKILDTNSYNFARFCFNNLSIPLKRTIVCGDDEQDIINSLNILLKQDKLDLIITSGGLGSTHDDITYKVISDYFQLDYQLDQEVVDRMKSIRGDYLDKLNPEQLNAFYRMATLPVSPQPSSLAQNSTTTTPATTVEKYFIDDKLWFPIVGLNEQVYILPGVPQLFTQLIKDMEPMLKPRVISSDLIRRYVVTKSGETQLAPYLTNLQEKCDKKYGKGVLKLGSYPHMNLHINTISIIGQKLTSQDLDWIVKALIENIGGDAKEITQAQEDEYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSE2</accession>
    <name>C4YSE2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSE2"/>
    <dbReference type="SMR" id="C4YSE2"/>
    <dbReference type="PaxDb" id="5476-C4YSE2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05005"/>
    <dbReference type="HOGENOM" id="CLU_027974_3_2_1"/>
    <dbReference type="OMA" id="WQFNFLY"/>
    <dbReference type="OrthoDB" id="1164111at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000107">
        <property type="entry name" value="Poly(A) ribonuclease POP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="485" mass="54643" checksum="3955FAA8512FF88B" modified="2009-07-28" version="1">MNVNPHLQYLQQQQQQQQQQQSQPSQSNQSQSNQSPQFSQLQLQQLQRQQLLNQHLQQQQSQSQSSQVPPQLTQQSMGTPTSTNPLLAVLNGGANSNATSTGNGSLSSNPVLQQLQLQQLQQQVQLQQLQAQQQQQQQQQQQAIPIIKEVWSSNLEHEFQALRTFINDKTSKVFIAIHQEIPGIVARPVGTFKSSSDYHFQTLRANSDLLNLIQLSLCVIKISKNETISTPVIWQFNFLYDLTKEMYNEEHLAMLAQTSQINFQLLSTHGIPHFEFAELMIESGLILDDNINWVSFHAGYDLGFFVSLLSNDDLPVDEPDFYWWCAKYFPNFYDLKYIGNQILNKSTTNGAGGTNSNTLDEKTNKPSIEYLAEELHLLPISPAIRQHFTNSTFHSQQLTSTLHAYLSMECFKELLRRSNMTLLSRFKGTIWGLGTFSGGTSINNTNNNGVTEDEIVASRINGISTPSTPVGIISKSGMVHFGGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSN9</accession>
    <name>C4YSN9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_05107</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSN9"/>
    <dbReference type="PaxDb" id="5476-C4YSN9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05107"/>
    <dbReference type="HOGENOM" id="CLU_033261_1_0_1"/>
    <dbReference type="OMA" id="NYSKWDQ"/>
    <dbReference type="OrthoDB" id="440202at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="8">
        <location>
            <begin position="204"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 C-terminal" evidence="7">
        <location>
            <begin position="411"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="201"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ46742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="508" mass="58388" checksum="4AC8DB4ACB4862D0" modified="2009-07-28" version="1">MPIDYSKWDKIEISDDSDVEVHPNVDKQSFIRWKQRDIHEKRMQRNIEIKSILIQLTMYAKLNERVDYLLEKLTSTELLDSEKVMSKLNSEFDPQEKFDYDKLIKDKGSTLRKGLKDLKFDREEIENTPCYNEMIEDLFVQIKDDHPGTKTDGDKLIECLKEHRNKIDDVLSKQTIKLDDLLYQKAQLIVSDDLHTGFDRSFLNKDKPEEKEEKQDKPKAPEAKKTTVTTTETINSPKPVEENTDKEILDELEILPATKEFAKIPSDNLSKAAEFLIKHPSICTEQQKDALIMTAFDLQLENKSDEAKHIVHQSLLLQYVGQLSGNGKAAPANVINAIKLFFSKIAAESSPAKHAFLEDVNQTFNHIKGRCEIIKEEQRQNAANKEGTGEEEEEEALIQLKALDDNTELSVNIPQEGTKEYEIFTTKLPIEFQNAIKTESIDEVNKEFAKLKIEDAERILEIFNECGVIGISGYIEDEKEFEELKKEYAHETANQEEDQSASVEDTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSP6</accession>
    <name>C4YSP6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_05114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSP6"/>
    <dbReference type="PaxDb" id="5476-C4YSP6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05114"/>
    <dbReference type="HOGENOM" id="CLU_109474_0_0_1"/>
    <dbReference type="OMA" id="DNEMPND"/>
    <dbReference type="OrthoDB" id="3991133at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="226" mass="27036" checksum="CCE524C4AD45CD4E" modified="2009-07-28" version="1">MYKPKFTFRPNAKGIILHKPVINISTTFDEISKLPSFRSKLLAFYKRFYKLRKFECNDQLYIIKDIPYYTPDINDQDYVAFVKRQFRSISYNTKREAILNLPALSEQELVQRMMNTLVFVFNHTVTKENLFLDKSIRTKDESAKTGIDNEETKIVSTILKLDNEMPNDIKYDFKFRWFKEFTKQMDSIDPKVGPTKNQLEYLTEHYGYRMYYITLMRLNESAKLCL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSU5</accession>
    <name>NNRD_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">CAWG_05164</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19017"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.93" evidence="1"/>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSU5"/>
    <dbReference type="SMR" id="C4YSU5"/>
    <dbReference type="PaxDb" id="5476-C4YSU5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05164"/>
    <dbReference type="HOGENOM" id="CLU_030651_0_0_1"/>
    <dbReference type="OMA" id="WRAAYHN"/>
    <dbReference type="OrthoDB" id="8110916at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
        <property type="entry name" value="YJEF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000416181" description="ATP-dependent (S)-NAD(P)H-hydrate dehydratase">
        <location>
            <begin position="1"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="YjeF C-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="201"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="245"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03157"/>
        </source>
    </evidence>
    <sequence length="360" mass="39929" checksum="E79D260C6CF8588D" modified="2009-07-28" version="1">MLRNKSQKELLHLSRQLIQPLLPNFHKGQAGKIVVIGGNEDYTGAPFFASHSAALVGADLSHVICEKAAGPVIKSYSPDLMIHPYLMDLDNPHLNLNNSELEKLKNLPIDEIIKTNDNAVLNKLIDELILPKVTSLLNRIDIVVVGPGFGRDPLMLKSLIRIIEEVKVLNLPIILDADSLYLVSLSPKIIANYPKAIITPNVVEFQRIAKALSIDVDLSESNKDKLIDQTIEVSRKLGDIIVFRKGEHDLIVKSSKFLINEITGSNKRVGGQGDTLTGAIATLVNWSNNYILRLWDNQVDLDQEDANLLACFAASSVVRNASSKAFNKYGRSMQTSNVHEYLHESFTELFGDSIFRTSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSU8</accession>
    <name>C4YSU8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Lysophospholipase</fullName>
            <ecNumber evidence="2 10">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_05167</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the release of fatty acids from lysophospholipids. Phospholipase B may well contribute to pathogenicity by abetting the fungus in damaging and traversing host cell membranes, processes which likely increase the rapidity of disseminated infection.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="2 10"/>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSU8"/>
    <dbReference type="PaxDb" id="5476-C4YSU8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05167"/>
    <dbReference type="HOGENOM" id="CLU_014602_0_1_1"/>
    <dbReference type="OMA" id="GPEQYSL"/>
    <dbReference type="OrthoDB" id="4084751at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000010">
        <property type="entry name" value="Lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF33">
        <property type="entry name" value="LYSOPHOSPHOLIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 9 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005125145" description="Lysophospholipase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="11">
        <location>
            <begin position="30"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ46801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="609" mass="67330" checksum="E772B697BD127969" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSZ7</accession>
    <name>C4YSZ7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_05694</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSZ7"/>
    <dbReference type="SMR" id="C4YSZ7"/>
    <dbReference type="PaxDb" id="5476-C4YSZ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05694"/>
    <dbReference type="HOGENOM" id="CLU_141397_3_0_1"/>
    <dbReference type="OrthoDB" id="1551503at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050673">
        <property type="entry name" value="Mito_inner_translocase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13172">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="14">
        <location>
            <begin position="13"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ47133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="110" mass="12957" checksum="F257CA919739C00F" modified="2009-07-28" version="1">MDQLNVKEQQEFQQIVEQKQMKDFMNLYSNLVSRCFDDCVNDFTSNSLTSKETSCIAKCSEKFLKHSERVGQRFQEQKYVDLSRVTNGNMPLMIIIIYHQIILTNKLILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT30</accession>
    <name>C4YT30_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">THUMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_05728</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT30"/>
    <dbReference type="SMR" id="C4YT30"/>
    <dbReference type="PaxDb" id="5476-C4YT30"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05728"/>
    <dbReference type="HOGENOM" id="CLU_039352_2_2_1"/>
    <dbReference type="OMA" id="MNEKACV"/>
    <dbReference type="OrthoDB" id="367221at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2300.10:FF:000001">
        <property type="entry name" value="THUMP domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2300.10">
        <property type="entry name" value="THUMP superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="4">
        <location>
            <begin position="133"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="61"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ47166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="268" mass="30924" checksum="44849A867BF8E925" modified="2010-10-05" version="1">MGKRKAADSNNPPKKKFKNVSKLLDPNTSGIYVSCARRKEANCRQELLNLLSEKVPEYFDLENVEDDEDETQIDKKELSIEDKIKQELQELEESKNSKKELLQPVDVDLECLVFIKTKKPIDPEVLVEKLCKECYESGQKTTRYTQKLVPIMDSCSSTGDDPLEKVRQLARKVLARHFHQEKDQKPVKFAVQVSRRNFNVLKSDVIIKTIAECVGNSHGHSVDLKNYDKLIIVECYKNNIGMGVANNFLKYSKYNLQQIFDKHQEDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT53</accession>
    <name>C4YT53_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_05752</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT53"/>
    <dbReference type="SMR" id="C4YT53"/>
    <dbReference type="PaxDb" id="5476-C4YT53"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05752"/>
    <dbReference type="HOGENOM" id="CLU_069169_0_0_1"/>
    <dbReference type="OMA" id="SHKEAHH"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060258">
        <property type="term" value="P:negative regulation of filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002160">
        <property type="entry name" value="Transcriptional regulator NRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001382">
        <property type="entry name" value="Transcriptional repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="256"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="85"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ47189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="310" mass="34299" checksum="FC798E706E6CE147" modified="2010-10-05" version="1">MLYQQSYPITNKLLNASAAGSTSTASIIDGGCTLSKPGSGKTKSTTSLPSFNELLTSIPLPNEFKPSTKNTNQAAAATATSPYNYYMGPPAQHRLPTPPPYPMSSPTTATAATPLSQQSPHLQPQQTLQQPQPYHQQYYNYQYAAPPYPHPSQVPPPASYQQRHQQPMYQNTNGVPIIIRPSPGLITPTSTTFDHAKIRSNSTGDLSANSLALSSNNNTQSKDPRRKHVCKVCSRSFTTSGHLARHNRIHTGERKHQCPWPTCEARFARQDNCNQHYKTHTNGKNKRNRQQHRTLEASHVGTKYNTKSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT66</accession>
    <name>C4YT66_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT66"/>
    <dbReference type="SMR" id="C4YT66"/>
    <dbReference type="PaxDb" id="5476-C4YT66"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05765"/>
    <dbReference type="HOGENOM" id="CLU_008694_0_0_1"/>
    <dbReference type="OMA" id="CERTTNI"/>
    <dbReference type="OrthoDB" id="4097129at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="475"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ47202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1137" mass="133171" checksum="76427DF6D14357FC" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTC4</accession>
    <name>C4YTC4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutaminyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_05411</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTC4"/>
    <dbReference type="PaxDb" id="5476-C4YTC4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05411"/>
    <dbReference type="HOGENOM" id="CLU_001882_2_3_1"/>
    <dbReference type="OMA" id="TWCIYPM"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00807">
        <property type="entry name" value="GlnRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000007">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2420:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000015">
        <property type="entry name" value="Glutaminyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000183">
        <property type="entry name" value="Glutaminyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1290">
        <property type="entry name" value="Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007638">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007639">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042558">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042559">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04558">
        <property type="entry name" value="tRNA_synt_1c_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04557">
        <property type="entry name" value="tRNA_synt_1c_R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding" evidence="15">
        <location>
            <begin position="10"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding" evidence="14">
        <location>
            <begin position="169"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="12">
        <location>
            <begin position="251"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="13">
        <location>
            <begin position="568"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="16">
        <location>
            <begin position="680"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ46865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="799" mass="91308" checksum="D2420DB0405CA66E" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTE9</accession>
    <name>C4YTE9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Replication factor C subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Activator 1 41 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_05438</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTE9"/>
    <dbReference type="SMR" id="C4YTE9"/>
    <dbReference type="PaxDb" id="5476-C4YTE9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05438"/>
    <dbReference type="HOGENOM" id="CLU_042324_1_0_1"/>
    <dbReference type="OMA" id="GCQSGSF"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000011">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000032">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000237">
        <property type="entry name" value="replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="56"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ46890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="363" mass="41554" checksum="87AA30B43B90A272" modified="2010-10-05" version="1">MDSTGTTIRKQKNQAYEEEKLHHTPWVEKYRPKSLNDVSSQEHTIKVLTQTIKSGNLPHMLFYGPPGTGKTSTILALAKELYGPNLYKSRVLELNASDERGISIVREKIKNFARLTISNPTKEDLQNYPCPPYKIIILDEADSMTNDAQSALRRTMENYAGITRFVLICNYITRIIDPITSRCSKFRFKLLNNENAQLRLKYIGQQENLRFESENNEHQVIQELLKISGGDLRKAITYLQSAAKLSETFDINHHQSLITIQSIRETAGILPDDILAELIQFIKSKTQQSRLIKYIDQSIILSGWSAQILLDQLHDKLILDESINSLSKNKISQIFFQSDRKLNNGTDEHIQLLNVLLQISQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTG9</accession>
    <name>C4YTG9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_05461</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTG9"/>
    <dbReference type="PaxDb" id="5476-C4YTG9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05461"/>
    <dbReference type="HOGENOM" id="CLU_003753_1_0_1"/>
    <dbReference type="OMA" id="PDQMKHR"/>
    <dbReference type="OrthoDB" id="2192888at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012978">
        <property type="entry name" value="HEAT_RRP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057860">
        <property type="entry name" value="HEAT_RRP12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25772">
        <property type="entry name" value="HEAT_RRP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08161">
        <property type="entry name" value="RRP12_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRP12 N-terminal HEAT" evidence="6">
        <location>
            <begin position="29"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="RRP12 HEAT" evidence="5">
        <location>
            <begin position="351"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1015"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1108"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1164"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1115"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1194"/>
            <end position="1217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ46910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1217" mass="135908" checksum="8A8D0499CFCBB188" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTH1</accession>
    <name>C4YTH1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_05463</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTH1"/>
    <dbReference type="PaxDb" id="5476-C4YTH1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05463"/>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="OMA" id="HKEATIF"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ46912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="347" mass="38550" checksum="13AF40AFF1379281" modified="2009-07-28" version="1">MSKTVILTGASGYVGQHILGELLDQNYKVIAIVRSQKSSDTLSKLFKQNPKLQFEIVEQFDKPHALDKVLEKHKEATIFISTAAVVTFHAEDYERDVLDPAIDLVKNIFSSIKEHAPQITRVILTSSSASVVGLDKAFSYDAEYSDNDWSPFTREMSTSDGTMAYFASKKLAEKEAWKFLKEEKPNFDLVAIMPALILGPVCFSSELKNGKFPSTSGIIGGLLHLKSDDPIQPMAAGAVDVRDVAKVHVDVITSEKASNQRILVESGKVTNDNIIQTIIDNFPSYKDKLPTPNPVPHSKFVKPKDERSRKIIGFSLRSLDDSVVDLVKQIDQENSVIESIKKLDIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTJ7</accession>
    <name>C4YTJ7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTJ7"/>
    <dbReference type="PaxDb" id="5476-C4YTJ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05490"/>
    <dbReference type="HOGENOM" id="CLU_1916785_0_0_1"/>
    <dbReference type="OMA" id="IADNENC"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="129" mass="15538" checksum="970F26FF08C58DC7" modified="2009-07-28" version="1">MIMDSKLAFILFLIKMFILIEMIIQEFFTKSLEEEDDYDDDEQFDEKFNNNNNNIADNENCPDIIHDEEKSLIYNTMTKQYESRPTIMTLKKKKKSRTSIWGISLQEFIFFIICFIMIIFDWIVIYTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTU6</accession>
    <name>C4YTU6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Cytochrome c oxidase assembly protein COX20, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_05592</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the assembly of the cytochrome c oxidase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the COX20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTU6"/>
    <dbReference type="PaxDb" id="5476-C4YTU6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05592"/>
    <dbReference type="HOGENOM" id="CLU_125578_0_0_1"/>
    <dbReference type="OMA" id="IVGWEQC"/>
    <dbReference type="OrthoDB" id="14603at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022533">
        <property type="entry name" value="Cox20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586">
        <property type="entry name" value="CYTOCHROME C OXIDASE PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12597">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007871">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ47037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="171" mass="19807" checksum="329FCF1A1AAFB5A0" modified="2009-07-28" version="1">MGWFGGGSGSSSTPPSKVSIVTEYKPEEKTQQYLEDLPPKFEDSEPIPERQATLMDAAQRIKLSDFTVDRFISMPCFREAMITGFQAMGVLGVVTFLIHKNVQKTMNWSVGGFFLGNIIGWEQCRYLRRKSFQMIEKAQQERDEKNKKKWAEMQQSDDEDLKKFQEFNSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTU9</accession>
    <name>C4YTU9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U6 snRNA-associated Sm-like protein LSm4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTU9"/>
    <dbReference type="PaxDb" id="5476-C4YTU9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05595"/>
    <dbReference type="HOGENOM" id="CLU_099537_0_2_1"/>
    <dbReference type="OrthoDB" id="747253at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120114">
        <property type="term" value="C:Sm-like protein family complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="11076" checksum="B8F1408C30020730" modified="2009-07-28" version="1">MNLTLHNVIQTDSRGEKFMKIPEIYIRGIHIKYLRIPDDIMGYAKEQSMINMENRNRYQKRRGTSSGGSMSGGGSGGSGDSRRFNNRQSHGHNYGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCN6</accession>
    <name>C4YCN6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCN6"/>
    <dbReference type="PaxDb" id="5476-C4YCN6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00270"/>
    <dbReference type="HOGENOM" id="CLU_061220_0_0_1"/>
    <dbReference type="OMA" id="IWSILVY"/>
    <dbReference type="OrthoDB" id="3342455at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013920">
        <property type="entry name" value="DUF1774_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992:SF1">
        <property type="entry name" value="DUF1774-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08611">
        <property type="entry name" value="DUF1774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="265" mass="30599" checksum="C49240F16BE15658" modified="2010-10-05" version="1">MAYSIEELRTYKAVTIITLLLSIYGTLKYSGVPEGDLAYTPFTASNILLFIYWGVLYLWQIIYTAQIFFPDEYRLSVISLVGWHFPIFNVLIYIWSELFSNGHYIWSEIILILNFFNLLVLYFAHKTFAVKPLVNWFLIHVPLAAMPLSWVMFALFWNGAVMFHIHKLFGRILANVFIWDFLLVPGVFLLLFNDWAIGFTNAYLMFALAFGQLSTKVFALQWIFAFVIAGILTVWSFIALVVGGVREVSDERAPLLVEVQETVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCW4</accession>
    <name>C4YCW4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular mutant protein 11 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCW4"/>
    <dbReference type="PaxDb" id="5476-C4YCW4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00348"/>
    <dbReference type="HOGENOM" id="CLU_1077678_0_0_1"/>
    <dbReference type="OMA" id="INSQNTM"/>
    <dbReference type="OrthoDB" id="4056678at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="29598" checksum="36362D3974080248" modified="2009-07-28" version="1">MAKNAHSISTATDSSAYSSGKSSTKHGHRNKRLKSTNSSRYMVQETPVPVQTNSEISQNLKTSTLTTTTTNSNNDNNNGNTNEIAILNSSPLKQLSPSQPLPEVLPTEPDENQPASFEQSQSTKFPIDVIPIQSSHATNESSVLEDQSLLDRSYWSKQVFEFNVDPLSCSIGTNPININSQNTMEIPTELSFSVWSNALLESIQREMILYQSLIVKRYKLFQQFEFLNTIVNNYADDLIQQENQLIEKINLIKVKLAEIIERGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCY3</accession>
    <name>C4YCY3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_00369</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCY3"/>
    <dbReference type="PaxDb" id="5476-C4YCY3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00369"/>
    <dbReference type="HOGENOM" id="CLU_010374_0_0_1"/>
    <dbReference type="OMA" id="YTVWNTL"/>
    <dbReference type="OrthoDB" id="391817at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="AP endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
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        <property type="entry name" value="AP_endonuclease_F1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF4">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00728">
        <property type="entry name" value="AP_NUCLEASE_F1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="10">
        <location>
            <begin position="27"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="391"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="8">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="8">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ42169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="451" mass="51940" checksum="C15F38DE4092F519" modified="2009-07-28" version="1">MNEELLSKDPLNKIISKSKGDSTIRYITFNVNGVKTIFNYHPWNQLKNNKDFNTLFNLLQADIITLQELKLTETSLQQQMSQLVHLSDYKSFISIPVTKKGYSGVGLFIRNPKSNENKKHRKHLTVIKAEEGITGWLPSSSSSSSSSSSANKIPYRESANNIGGYTDIEKLPGLHLDSEGRCVCVELADNTVIFAVYCPANSQCTYDGELFRLTFIKLLLQRCYNLVKLYPQKKIVIMGDINIAIDMIDHAETIELGIKENLLKPSFRGHNFEVLNYENCVSFRTATEARKLLNKYVIRSIWQDLKNEKNPNQKEREKEEPFLYDTTRLVQGRRMKMYTVWNTLTNARQINHGSRIDLILFSDEKMVQRISNADIWPFLMGSDHCPVFTDCDMSDEDEDEDEDEDENEDGNKTSVDLIEQPKLSFEAKNHFKINKVRDITSFFGSKRQKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD10</accession>
    <name>C4YD10_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_00398</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD10"/>
    <dbReference type="PaxDb" id="5476-C4YD10"/>
    <dbReference type="HOGENOM" id="CLU_020591_0_0_1"/>
    <dbReference type="OMA" id="DFVYRGV"/>
    <dbReference type="OrthoDB" id="4096469at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052881">
        <property type="entry name" value="Keratinocyte_PR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014010">
        <property type="entry name" value="REJ_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48138:SF2">
        <property type="entry name" value="KERATINOCYTE PROLINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48138">
        <property type="entry name" value="KERATINOCYTE PROLINE-RICH PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51111">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="REJ" evidence="3">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ42196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="579" mass="59140" checksum="0D5C6F7234454FCA" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD23</accession>
    <name>C4YD23_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_00411</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="2"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD23"/>
    <dbReference type="PaxDb" id="5476-C4YD23"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00411"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_5_1"/>
    <dbReference type="OMA" id="KHTVVKL"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010607">
        <property type="term" value="P:negative regulation of cytoplasmic mRNA processing body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="90"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="345"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="33"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="363"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ42209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="402" mass="46402" checksum="3ECB08FF295C1AD8" modified="2009-07-28" version="1">MEPADTSIRSLNDINLQELANKQHQRNIYAQGSPTLEDSITSNGNDINNPNNNINKTNNNSNSSLSLTKKTSRHINKDTTTKGKYTLNDFQILRTLGTGSFGRVHLTRSIHNGRFYAMKVLKKQRVVQMKQIEHTNDERRMLKLAQHPFIIRMWGTFQDCHNLFMIMDYIEGGELFSLLRKSQRFPTPVAKFYAAEVFLAIEYLHSLDIIYRDLKPENILLDKNGHIKLTDFGFAKEVQDVTYTLCGTPDYIAPEVVATKPYNKSVDWWSFGILIFEMLTGYTPFYDPTPMKTYENILNGSITYPDYLPPDILDLLQKLIVKDLTQRLGNLQGGSDDVKNHPWFKEVIWERLLSRDIETPYEPPITSGVGDTSQFDRYPEDKDLDYGISGVEDPYRDQFQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD46</accession>
    <name>C4YD46_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD46"/>
    <dbReference type="ESTHER" id="canal-q5apu4">
        <property type="family name" value="Monoglyceridelipase_lysophospholip"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YD46"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00434"/>
    <dbReference type="HOGENOM" id="CLU_026209_5_0_1"/>
    <dbReference type="OMA" id="RQFNDMF"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000766">
        <property type="entry name" value="Acylglycerol lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="40"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="304" mass="34881" checksum="E0EC4709D6606A2C" modified="2010-10-05" version="1">MTTVEIPYKPKGTPEIEFVEHNGANFKTVTWKVPQSVSYKGKIIYVHGFAEESNVYTEFFDNLSQNGYEVFFFDQRGAGETSPGNLVGLTDEFHVFNDLDFFIKRNLDARPAANSNEKFFLLGHSMGGGIILNYGIRGKYLNDIRAIVASGPLIQLHPNTQPNIVLRTLQPVISRLLPNFKIDSKLNFDYITSNERWKNYIIEHDKKLIGSVRQFNDMFVRGDALLKPEYVAKFKDDLPLLIVHGTNDNINDIKGSEQFFKLVPNDSGNKHLEKIEKGRHSLFIENDELFKLIFKRVIDFLNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>C4YD89</accession>
    <name>C4YD89_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_00479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YD89"/>
    <dbReference type="PaxDb" id="5476-C4YD89"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00479"/>
    <dbReference type="HOGENOM" id="CLU_170514_0_0_1"/>
    <dbReference type="OMA" id="WMRIKRA"/>
    <dbReference type="OrthoDB" id="4024333at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ42275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="111" mass="13129" checksum="E764F0C86BFC0B55" modified="2010-10-05" version="1">MRSLPPPRITRARKWKRIKRAIKNLFSKGYISDYGVFSRIQANHYSISKIRRSRFSTRLVKSRNDLNIVKRANRGFKLANYISRASRRVSVSGLKRGLRSPKSRMDFRINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDC9</accession>
    <name>C4YDC9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_00521</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EEQ42315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YDC9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00521"/>
    <dbReference type="HOGENOM" id="CLU_086434_0_0_1"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Flocculin_t3"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944644" evidence="6">
        <location>
            <begin position="20"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ42315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="219" mass="22101" checksum="46B537E9649ECBAB" modified="2010-10-05" version="1">MQFQTLLVVAGSLVASTLAVNSTVTEHHTTEITITHCSDNKCATSVAPAVQSVNTVTIEGVVTEYTTYCPLTASEHKHKESSSPSSVAPVASTESVVTTTISGVHTSYTTYCPLSGSSEASTVITPGTVAGESSSSSEEVSYVDVTSTPVVESTTDVELTLTAQSTLFTSYANSTGSSSSSSVVPSANVTTFEGGAVGGASNQITVGFAAIAGLAAILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDE9</accession>
    <name>C4YDE9_CANAW</name>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Candida albicans (strain WO-1)</name>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1758553_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ42335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="157" mass="18409" checksum="3CB6BA840CB8B493" modified="2009-07-28" version="1">MSNDNTVQVNKPETLASILEYLQQESIFSAEDKCSQDEILKDCPQFFVNDPSKKLNWQQLAECFEDVFTKYTAETCELKEQIEELVQVRPISFSHYWHLNPLLTLICSPNRNEKHYLKVMKSSIRKELKLGKFKRLSVNLSFLFSHINSIILVLKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDI0</accession>
    <name>C4YDI0_CANAW</name>
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        <recommendedName>
            <fullName evidence="3 9">Chromatin modification-related protein EAF6</fullName>
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    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_00575</name>
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    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDI0"/>
    <dbReference type="PaxDb" id="5476-C4YDI0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00575"/>
    <dbReference type="HOGENOM" id="CLU_093901_0_0_1"/>
    <dbReference type="OMA" id="GPMEQNR"/>
    <dbReference type="OrthoDB" id="440324at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13476">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="152"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ42366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="211" mass="23149" checksum="D4E016C7235D7527" modified="2009-07-28" version="1">MSTKDANDVKPTSSKSNEISSSGTATPKKTSSVPAKEDRKDTTKKDIANERTSSSKSKDDSEKYVELKNKLIQQILKKQELTRKLTTLEDSIYQKEIDYFEESPLGNIVKGFENFSKTGGGGGANKRKIVYSEDDHIFSLSSVNYIKSLMKRQGHTSNGGSSKDDFDDYEDSVDPTTASAGSKANSIEKNETPSGSSGTPSRKRKARVLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDN9</accession>
    <name>C4YDN9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Nicotinate-nucleotide pyrophosphorylase [carboxylating]</fullName>
            <ecNumber evidence="5 12">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_00636</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Hexamer formed by 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="5 12"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDN9"/>
    <dbReference type="SMR" id="C4YDN9"/>
    <dbReference type="PaxDb" id="5476-C4YDN9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00636"/>
    <dbReference type="HOGENOM" id="CLU_039622_1_0_1"/>
    <dbReference type="OMA" id="DIVMCDN"/>
    <dbReference type="OrthoDB" id="10067394at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034213">
        <property type="term" value="P:quinolinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000090">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.20:FF:000003">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="entry name" value="Quinolinate phosphoribosyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179:SF3">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase N-terminal" evidence="14">
        <location>
            <begin position="38"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase C-terminal" evidence="13">
        <location>
            <begin position="122"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ42425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="300" mass="32463" checksum="1B8608A6AB5B86C3" modified="2010-10-05" version="1">MAPEYANLLPVSGNWKQKITDYLTEDVPSFDFGGFVVGNTPETGSLYMKQSGVICGIPFVNEVFHQCNLQHKWIFSEGQFVSDKEIASAGGKIVVCTVKGSASNILLAERTALNLLSRASGVATQSYKTKKLADESGYTGIIAGTRKTTPGLRQLEKYAMLIGGVDTHRYDLSSMVMLKDNHITSTGSITKAVKKAKSVCGFAVKVEVEVSNEKDAEEAIEAGADVIMLDNFKGEELRQVAQSLKKKFAGTNKSFLLECSGGLTLQNLSSYLSNDIDIYSTSSIHQGVSTIDFSLKIDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YE04</accession>
    <name>C4YE04_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription factor IWS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Transcription factor iws1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_00753</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IWS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YE04"/>
    <dbReference type="PaxDb" id="5476-C4YE04"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00753"/>
    <dbReference type="HOGENOM" id="CLU_045275_0_1_1"/>
    <dbReference type="OMA" id="MPAYNIQ"/>
    <dbReference type="OrthoDB" id="21124at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.10:FF:000003">
        <property type="entry name" value="Putative Transcription factor IWS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="10">
        <location>
            <begin position="211"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="65"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ42540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="400" mass="45771" checksum="9D345965787280D3" modified="2009-07-28" version="1">MSDPLADYTNLSHDEIDPSSANAAESEQEKPEQQVSEHYEPQPEELTYENDENVLNSIKVQKITDAEAIGEVVRKKVIRDSRPQGYEQGDFNDNSNVTSGSRPGHQQTDEIDISSMDPQQRKRFELEERMSAAIKPSNKRRRKADEDDLERMQDDKIDYLKDQMIKAANSDVEKNSQGQIATEKLKLLKEVSDILARADLAIPILDNNLLEAVRLWLEPLPDASMPAYQIQKELIHALETLPIKTDHLVASGIGKVLVFYQRSKRTEPSLKKIVDRLIGDWTRPILNKSDSYKDRTVQFHEYNRNKFTNKLSRGVKKREAKTLYEENAERRKRAAIPSTRTTAYKIAPQVDKSLLMRQQSRHASNDERFKRINSKLTSMSVKRKAAKKGGPSIEGRDLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YE60</accession>
    <name>C4YE60_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_00813</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YE60"/>
    <dbReference type="PaxDb" id="5476-C4YE60"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00813"/>
    <dbReference type="HOGENOM" id="CLU_005170_8_0_1"/>
    <dbReference type="OMA" id="DINNFPW"/>
    <dbReference type="OrthoDB" id="10260443at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01115">
        <property type="entry name" value="SLC13_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF110">
        <property type="entry name" value="INORGANIC PHOSPHATE TRANSPORTER PHO87-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="573"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="633"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="676"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="759"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="803"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="859"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="895"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="938"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="976"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="295"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ42596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1010" mass="113526" checksum="B1F9965E215E46D5" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YE91</accession>
    <name>C4YE91_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,3-beta-D-glucan-UDP glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_00845</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="C4YE91"/>
    <dbReference type="PaxDb" id="5476-C4YE91"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00845"/>
    <dbReference type="HOGENOM" id="CLU_000844_0_1_1"/>
    <dbReference type="OMA" id="WCPENGA"/>
    <dbReference type="OrthoDB" id="1880850at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056261">
        <property type="entry name" value="FKS1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23605">
        <property type="entry name" value="FKS1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1044"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1104"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1133"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1191"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1218"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1353"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1378"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1480"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1533"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="12">
        <location>
            <begin position="123"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ42627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1571" mass="182324" checksum="63E6B5817512C791" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YE96</accession>
    <name>C4YE96_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_00850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YE96"/>
    <dbReference type="SMR" id="C4YE96"/>
    <dbReference type="PaxDb" id="5476-C4YE96"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00850"/>
    <dbReference type="HOGENOM" id="CLU_130128_3_0_1"/>
    <dbReference type="OMA" id="ERINMPL"/>
    <dbReference type="OrthoDB" id="5567124at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.100:FF:000001">
        <property type="entry name" value="40S ribosomal protein S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_eS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_eS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_eS27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11594">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01168">
        <property type="entry name" value="RIBOSOMAL_S27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ42632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="82" mass="9123" checksum="BA372879DA175A4F" modified="2009-07-28" version="1">MVLVQDLLHPNPITENEKNKLKKLVQEPNSFFLDIKCPSCFNIKTIFSHAQTAITCDKCSTLLSSPTGGKAKLVDGSSFRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEX5</accession>
    <name>C4YEX5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein HOL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_01084</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEX5"/>
    <dbReference type="PaxDb" id="5476-C4YEX5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01084"/>
    <dbReference type="HOGENOM" id="CLU_008455_13_3_1"/>
    <dbReference type="OMA" id="DQYYDPP"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000224">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF34">
        <property type="entry name" value="PROTEIN HOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="514"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="82"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ42861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="586" mass="65180" checksum="0C04CCBC3648986A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEY3</accession>
    <name>C4YEY3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cell division control protein 73 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_01092</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC73 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEY3"/>
    <dbReference type="PaxDb" id="5476-C4YEY3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01092"/>
    <dbReference type="HOGENOM" id="CLU_025849_2_0_1"/>
    <dbReference type="OMA" id="GYYFHFA"/>
    <dbReference type="OrthoDB" id="2186602at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11990:FF:000010">
        <property type="entry name" value="Uncharacterized protein Ca49C10.12c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11990">
        <property type="entry name" value="RNA polymerase II accessory factor, Cdc73 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007852">
        <property type="entry name" value="Cdc73/Parafibromin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031336">
        <property type="entry name" value="CDC73_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038103">
        <property type="entry name" value="CDC73_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466">
        <property type="entry name" value="CDC73 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466:SF8">
        <property type="entry name" value="PARAFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05179">
        <property type="entry name" value="CDC73_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Cell division control protein 73 C-terminal" evidence="6">
        <location>
            <begin position="208"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ42869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="370" mass="42447" checksum="E3FED15809A0EC57" modified="2009-07-28" version="1">MSSSSPLKAFRKAVIKEERIEFFKNDETTGSINDATEVQFGTDKNKYSLDMATNFYNDEKLTDAQSLRSVVFCYLHEKDSITDYKVAGESLNIPVFSFLVKTELSTWLHGNSDTCMFIKKEAEDKTSKSVKSTDSSSQVNNKKHKLDDPQLERISKFERESVDHNAALRGSKNIDFGYLVSDAKKFMHELKRTKHMPRTNSQGNSGPKKQPIILVSPATTALLSLSNIKEFLEDGVFTEPVPGNRPNGGLVIVNHPSDKLISTGQKIMVVDNIENFNKMEYWDRVIAIFTTGQTWQFSRYIHPEPEVLFQKYRGFYFGYQGEIAPPQIKDWNVTEVRVDRDKRFKDKVIVRDFWVEIEKILVNKGYGKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF64</accession>
    <name>C4YF64_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hsp30p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_01176</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YF64"/>
    <dbReference type="PaxDb" id="5476-C4YF64"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01176"/>
    <dbReference type="HOGENOM" id="CLU_054785_1_1_1"/>
    <dbReference type="OMA" id="IFTTMFM"/>
    <dbReference type="OrthoDB" id="536545at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15239">
        <property type="entry name" value="7tm_YRO2_fungal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000160">
        <property type="entry name" value="Related to Opsin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043476">
        <property type="entry name" value="Yro2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF1">
        <property type="entry name" value="30 KDA HEAT SHOCK PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ42950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="37871" checksum="15B4BAD55961880E" modified="2009-07-28" version="1">MAVASTFIHNNLEVMNRNTATKVNPTNSLVNMHITDHGSDWLWAAFSVFLLLTIIHLLLFLYGNFRKPGVKNSLLVIPLFTNAVFSVFYFTYASNLGYAWQAVEFQHAGTGLRQIFYAKFIAWFVGWPAVLALFEIVTSTVLDRIEENPNIFKKFFLIFQTWLVKFIFVEIYVLGLLIGSIIFSTYKFGYFTFAVFFQLLLMVWVGRDLHRSFKSPSHSNIANFFLIFFYLVWILYPVAWGLSEGGNVIQPDSEAVFYGILDLITFGLMPTILIFFAIKGCDEEFFSKLWQYHVKSEAESIHENEKAVAETPSTEAGVVDAEVDNEPQAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFF7</accession>
    <name>C4YFF7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="5">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_01270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="5"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFF7"/>
    <dbReference type="PaxDb" id="5476-C4YFF7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01270"/>
    <dbReference type="HOGENOM" id="CLU_031040_8_1_1"/>
    <dbReference type="OMA" id="DEQWRAE"/>
    <dbReference type="OrthoDB" id="44061at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00357">
        <property type="entry name" value="peptide-methionine (R)-S-oxide reductase MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081:SF8">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="6">
        <location>
            <begin position="18"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ43038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="147" mass="16728" checksum="ED520BA20F3F20B7" modified="2009-07-28" version="1">MFKSSAFRTFVRNMSKSDSEWRAILSPEQFRVLRQGGTETPYTGEYTNAPASDVGYYECAGCKYPLYKANTKFKAHCGWPAFYEALPGAVKIYRDESHGMIREEMRCSNCDGHLGHVFKGEGYKTPTDERHCVNSVSIKFNPQDQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFG5</accession>
    <name>C4YFG5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_01283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFG5"/>
    <dbReference type="PaxDb" id="5476-C4YFG5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01283"/>
    <dbReference type="HOGENOM" id="CLU_046065_1_0_1"/>
    <dbReference type="OMA" id="FAICNAD"/>
    <dbReference type="OrthoDB" id="10251073at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10567">
        <property type="entry name" value="SWIB-MDM2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="52"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ43046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="172" mass="19564" checksum="856BEAD776F366CA" modified="2009-07-28" version="1">MERQDALLAAKLSREEMGRFGKRTIRKATQTASKIKSSKSKSNTKRSAPNNAFNREMALSPELTNVIGVDKCSRPQVVKLLWAYIKDHNLQNPQDKRQIECDEKLQKLFKKKNVGAFHMNKILSDHIFKPEDWETSFSSTGIGSSMTEEDPDPDTTQDFANNVKEESVSEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFI9</accession>
    <name>C4YFI9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_01307</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFI9"/>
    <dbReference type="SMR" id="C4YFI9"/>
    <dbReference type="PaxDb" id="5476-C4YFI9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01307"/>
    <dbReference type="HOGENOM" id="CLU_044998_0_1_1"/>
    <dbReference type="OMA" id="EHNHNVV"/>
    <dbReference type="OrthoDB" id="421009at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021538">
        <property type="entry name" value="Syntaxin-5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11416">
        <property type="entry name" value="Syntaxin-5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="246"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="165"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ43070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="337" mass="38182" checksum="0387C80B0DF25DD7" modified="2010-10-05" version="1">MSTSIQNRTIEFQQCVSTYDKINKKHNKHVNNSPALSTPKKSYFSQQAGLIAKDISHVTELLSKLAVLAKRKPIFDDKPIEIGELTYVIKQDIFKIETNIQNLQKYLKGDTSVSIDAQTTQFSKNVLTLLNSKMKNVSGEFKNVLEIRQKNEIINKNRTENFLSSVSASRSSNNQSPLVDNPNASLSNLSENPFLASSPPENLPYDPDADPDTSSPYGVSNNGEYLSLPSQTQQMLLMEEQQYGNQQYLQQRNRAVESIESTINEVGNLFQQLATMVSEQGEQIQRIDANVEDINMNITGAQRELLKYYAHITSNRWLFLKIFGVLIVFFFLWVLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFM8</accession>
    <name>C4YFM8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_01346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFM8"/>
    <dbReference type="PaxDb" id="5476-C4YFM8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01346"/>
    <dbReference type="HOGENOM" id="CLU_1299535_0_0_1"/>
    <dbReference type="OMA" id="FFTHEEF"/>
    <dbReference type="OrthoDB" id="4022859at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="212" mass="24716" checksum="0DE2B60DB9EBEBDD" modified="2010-10-05" version="1">MTTPTSILSPCDSCLTLSDKSQQYNSQYLMNYLSSRIPEEETEVSEITVVYDGNANINIKLCSVVCLINIYLHKKITVEDLTVNHLFVYLFYHQHNLFNKEIYIDQLKLVHLGKKYQFSTLHSIPSPRLIHDLQIERYPTLLLNIKEDNYLPFNLDVGYYLTCQQTFVDKSTGDVTCLDTLIRKWKRLQNHKNGSNTSKRRGLKNFLKSIMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFV1</accession>
    <name>C4YFV1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_00077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFV1"/>
    <dbReference type="PaxDb" id="5476-C4YFV1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00077"/>
    <dbReference type="HOGENOM" id="CLU_119129_0_0_1"/>
    <dbReference type="OMA" id="PNWKKAP"/>
    <dbReference type="OrthoDB" id="3784821at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ41890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="167" mass="19505" checksum="B5622173B0602423" modified="2009-07-28" version="1">MTSDKPSFHKEGKSTIKIVHDNNKNNNTKQHKRPITPKDISSQSQKVKDSPFVEELVLTGRPNWKKAPQQIKQRYKGIYLILLSIPIMGITTFEIIRRLEGKSTKKIQQGERLSNGINRDFDEQEKIKVEKESIMYKIFGKDFFLDGFTSKTIKSNQEKKERKEKHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG29</accession>
    <name>C4YG29_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal peptidase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_00145</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface. Essential for viability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPCS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YG29"/>
    <dbReference type="PaxDb" id="5476-C4YG29"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00145"/>
    <dbReference type="HOGENOM" id="CLU_068714_2_1_1"/>
    <dbReference type="OMA" id="LHWNIQP"/>
    <dbReference type="OrthoDB" id="10261524at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007653">
        <property type="entry name" value="SPC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04573">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016089">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ41953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="192" mass="21746" checksum="046D908162DB97CC" modified="2009-07-28" version="1">MFNLVTRAQAAANSALTSSIVITSVVIVLTLLQLYKDNVWSLNTTSITNIRPTASIKQSFHYGSLNRKPKENAKIQFDLSSDLTPLFNWNTKQIFIYLTAEYPGKSEGSSNKVTFWDKIITNKEDANLTLTNQRGKYSVWDVEKSFRGRNATVRLEWNIQPYVGPLIFGSTEGFGEFQFADTQKKKESTKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG85</accession>
    <name>C4YG85_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ribosomal RNA-processing protein 44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CAWG_00206</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YG85"/>
    <dbReference type="PaxDb" id="5476-C4YG85"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00206"/>
    <dbReference type="HOGENOM" id="CLU_002333_5_0_1"/>
    <dbReference type="OMA" id="GQVMRNN"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09862">
        <property type="entry name" value="PIN_Rrp44-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000309">
        <property type="entry name" value="Exosome complex exonuclease DIS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000010">
        <property type="entry name" value="Exosome complex exonuclease DIS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000001">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033770">
        <property type="entry name" value="RRP44_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF35">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17215">
        <property type="entry name" value="Rrp44_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 18" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S1 motif" evidence="17">
        <location>
            <begin position="909"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="223"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EEQ42009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1004" mass="113822" checksum="6A8858803333AB36" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGF9</accession>
    <name>C4YGF9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_03135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGF9"/>
    <dbReference type="SMR" id="C4YGF9"/>
    <dbReference type="PaxDb" id="5476-C4YGF9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03135"/>
    <dbReference type="HOGENOM" id="CLU_030397_1_0_1"/>
    <dbReference type="OMA" id="CPYDLFQ"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="240" mass="28040" checksum="E5D93126726BAAC6" modified="2010-10-05" version="1">MAEEQRRQIEQLMGKENGSSIRRRDPEMTSSRVCRAFLVGTCPHDLFVGTKQDLGRCPNLHLQKHKLEYEHRTKKLGEKFPDIEYDYYKLLSKYVSDLDRNIHNAQLRLQHTPEEKAKIARVTKELDDLDVEIGLMVQELNYLVAKNQASKIIDYAIELNAKCEEREKLSQQARRITENVGQTSQQKLQVCDGCGAYLSRLDNDRRLADHFVGKIHMGYLEIRENFKEVQNKYKKMGKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGI0</accession>
    <name>C4YGI0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_03157</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGI0"/>
    <dbReference type="SMR" id="C4YGI0"/>
    <dbReference type="PaxDb" id="5476-C4YGI0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03157"/>
    <dbReference type="HOGENOM" id="CLU_059055_1_0_1"/>
    <dbReference type="OMA" id="WNPNKSK"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000056">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="7"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ44862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="316" mass="33167" checksum="134803AB585BFB9F" modified="2010-10-05" version="1">MAFGAPRGRGGPARGGRGGFGGGRGGRGGARGGGRGGARGGSRGGARGGARGGARGGARGGRGGARGGARGGAKVVIEPHRHAGVFIARGKEDLLVTRNIAPGESVYGEKRISVEEPAKEEGAAPTKIEYRVWNPFRSKLAAGIMGGIDELGIAPGKKVLYLGAASGTSVSHVADVVGPEGLVYAVEFSHRPGRELIGMAKKRPNVIPIIDDARHPQKYRMLIGMVDCVFADVAQPDQARIIALNSHLFLKDGGLVVISIKANCIDSTVDAETVFAREVQKLREERIKPLEQLTLEPYERDHCIVVGRYMRSGIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGM0</accession>
    <name>C4YGM0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating</fullName>
            <ecNumber evidence="13">1.1.1.170</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">C-3 Sterol dehydrogenase ERG26</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 17">C-4 decarboxylase ERG26</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Sterol-4-alpha-carboxylate 3-dehydrogenase erg26, decarboxylating</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CAWG_03199</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>4beta-methylzymosterol-4alpha-carboxylate + NADP(+) = 3-dehydro-4-methylzymosterol + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:33447"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:50593"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:64925"/>
            <dbReference type="EC" id="1.1.1.170"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33448"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="12">Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer of ERG25, ERG26, ERG27 and ERG28. ERG28 acts as a scaffold to tether ERG27 and other 4,4-demethylation-related enzymes, forming a demethylation enzyme complex, in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.170" evidence="13"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGM0"/>
    <dbReference type="PaxDb" id="5476-C4YGM0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03199"/>
    <dbReference type="HOGENOM" id="CLU_007383_6_8_1"/>
    <dbReference type="OMA" id="STAHWFD"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000252">
        <property type="term" value="F:3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09813">
        <property type="entry name" value="3b-HSD-NSDHL-like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000346">
        <property type="entry name" value="C-3 sterol dehydrogenase/C-4 decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="20">
        <location>
            <begin position="9"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00067985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00082106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EEQ44902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="350" mass="39158" checksum="061E5D3348B03AC6" modified="2009-07-28" version="1">MSESLQSVLIIGGSGFLGLHSIEQFYRHCPNVAITVFDVRPLPEKLSKYFTFDPSKIQFFKGDLTSDKDVSDAINQSKCDVIVHSASPMHGLPQEIYEKVNVQGTKNLLSVAQKLHVKALVYTSSAGVIFNGQDVINADETWPYPEVHMDGYNETKAAAEEAVMKANDNDQLRTVCLRPAGIFGPGDRQLVPGLRASAKLGQSKYQLGDNNNLFDWTYVGNVADAHVLAAQKILDKSTRDDISGQTFFITNDSPTYFWTLARTVWKNDGYIDKYYIKLPYPVALTLGYISEFVAKNILKKEPGITPFRVKVVCAIRYHNIAKAKKLLGYKPEVDLETGINYTLDWMNEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGS1</accession>
    <name>C4YGS1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CAWG_03253</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 16">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Cytoplasmic vesicle</location>
            <location evidence="1 16">COPII-coated vesicle membrane</location>
            <topology evidence="1 16">Peripheral membrane protein</topology>
            <orientation evidence="1 16">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Endoplasmic reticulum membrane</location>
            <topology evidence="2 16">Peripheral membrane protein</topology>
            <orientation evidence="2 16">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Golgi apparatus membrane</location>
            <topology evidence="16">Peripheral membrane protein</topology>
            <orientation evidence="16">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGS1"/>
    <dbReference type="SMR" id="C4YGS1"/>
    <dbReference type="PaxDb" id="5476-C4YGS1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03253"/>
    <dbReference type="HOGENOM" id="CLU_008658_3_0_1"/>
    <dbReference type="OMA" id="FPPHYAE"/>
    <dbReference type="OrthoDB" id="10256289at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11287">
        <property type="entry name" value="Sec23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.730:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000041">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000008">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037550">
        <property type="entry name" value="Sec23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 16" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0813">Transport</keyword>
    <keyword evidence="9 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="18">
        <location>
            <begin position="53"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="19">
        <location>
            <begin position="121"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="21">
        <location>
            <begin position="400"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="20">
        <location>
            <begin position="512"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="17">
        <location>
            <begin position="625"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EEQ44953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="762" mass="85684" checksum="E237DFA01C4910A0" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGW5</accession>
    <name>C4YGW5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen debranching enzyme</fullName>
            <ecNumber evidence="5">2.4.1.25</ecNumber>
            <ecNumber evidence="6">3.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycogen debrancher</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CAWG_03301</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of (1-&gt;6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin.</text>
            <dbReference type="EC" id="3.2.1.33"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the glycogen debranching enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="5"/>
    <dbReference type="EC" id="3.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YGW5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03301"/>
    <dbReference type="HOGENOM" id="CLU_001517_2_0_1"/>
    <dbReference type="OMA" id="YEEGHVH"/>
    <dbReference type="OrthoDB" id="10248904at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004135">
        <property type="term" value="F:amylo-alpha-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11327">
        <property type="entry name" value="AmyAc_Glg_debranch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000070">
        <property type="entry name" value="GDB1p Glycogen debranching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000039">
        <property type="entry name" value="Glycogen debranching enzyme Gdb1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000242">
        <property type="entry name" value="Glycogen debranching enzyme Gdb1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010401">
        <property type="entry name" value="AGL/Gdb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032788">
        <property type="entry name" value="AGL_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029436">
        <property type="entry name" value="AGL_euk_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032792">
        <property type="entry name" value="AGL_glucanoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006421">
        <property type="entry name" value="Glycogen_debranch_met"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01531">
        <property type="entry name" value="glyc_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569:SF2">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14701">
        <property type="entry name" value="hDGE_amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14702">
        <property type="entry name" value="hGDE_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14699">
        <property type="entry name" value="hGDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Eukaryotic glycogen debranching enzyme N-terminal" evidence="18">
        <location>
            <begin position="48"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme glucanotransferase" evidence="19">
        <location>
            <begin position="139"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme central" evidence="20">
        <location>
            <begin position="723"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme C-terminal" evidence="17">
        <location>
            <begin position="1040"/>
            <end position="1514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF14701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF14702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EEQ44997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1527" mass="173915" checksum="0BDBC91A581B221D" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH19</accession>
    <name>C4YH19_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_03360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YH19"/>
    <dbReference type="PaxDb" id="5476-C4YH19"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03360"/>
    <dbReference type="HOGENOM" id="CLU_005481_0_0_1"/>
    <dbReference type="OMA" id="MSSMIQR"/>
    <dbReference type="OrthoDB" id="68020at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042791">
        <property type="term" value="P:5S class rRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16169">
        <property type="entry name" value="Tau138_eWH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046488">
        <property type="entry name" value="Sfc3/Tfc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035625">
        <property type="entry name" value="Tfc3-like_eWH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007309">
        <property type="entry name" value="TFIIIC_Bblock-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049543">
        <property type="entry name" value="WHD_TFC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04182">
        <property type="entry name" value="B-block_TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20222">
        <property type="entry name" value="DUF6581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21552">
        <property type="entry name" value="WHD_TFC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="B-block binding subunit of TFIIIC" evidence="7">
        <location>
            <begin position="128"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor tau 138 kDa subunit extended winged helix" evidence="9">
        <location>
            <begin position="713"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor tau subunit sfc3/Tfc3 C-terminal" evidence="8">
        <location>
            <begin position="965"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="203"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="560"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="846"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="343"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="913"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ45051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1089" mass="124843" checksum="ECC036F6725A811B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH87</accession>
    <name>C4YH87_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sorting nexin-41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_03431</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YH87"/>
    <dbReference type="PaxDb" id="5476-C4YH87"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03431"/>
    <dbReference type="HOGENOM" id="CLU_926057_0_0_1"/>
    <dbReference type="OrthoDB" id="289314at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051079">
        <property type="entry name" value="Sorting_Nexin_Autophagy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979:SF2">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ45119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="294" mass="33720" checksum="932E090E4685526A" modified="2009-07-28" version="1">MLDDINKRIMENYIGLSNDYSKLGSTFNSFSLILAEQQHTTTTTTTGVSSATKKSNDNELNLIFDKIGQVFDRSYITINSLIGELETKFSEPLGEIVQYTSIIHYVAKYQSKKIKQKSMLDNEIKDKRKTLEDLLKIERESNRIENAINSQVKPKNGKYNLEQQQSSTVSPAPPPGPPPSSSSSSSSSSKFKFPSFKKITQYVSEIIDQNPEVTRKQKITNLQEKIQILEKCQNIMLADLSFITDEVNKNIQSFQKRQLKMIYKILLLYNKQLIGWAKKNIDIWEEVRDEIAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHB7</accession>
    <name>C4YHB7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COP9 signalosome complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_03463</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. CSN5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHB7"/>
    <dbReference type="MEROPS" id="M67.A01"/>
    <dbReference type="PaxDb" id="5476-C4YHB7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03463"/>
    <dbReference type="HOGENOM" id="CLU_031199_1_0_1"/>
    <dbReference type="OMA" id="MISEWNR"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000003">
        <property type="entry name" value="COP9 signalosome complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="11">
        <location>
            <begin position="75"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="211"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="386"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ45149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="612" mass="69906" checksum="5C175A05AF816421" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHF0</accession>
    <name>C4YHF0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_03496</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHF0"/>
    <dbReference type="PaxDb" id="5476-C4YHF0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03496"/>
    <dbReference type="HOGENOM" id="CLU_348179_0_0_1"/>
    <dbReference type="OMA" id="KWHIDSV"/>
    <dbReference type="OrthoDB" id="4096at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23869">
        <property type="entry name" value="Beta-prop_WDR75_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="260"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ45182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="839" mass="93996" checksum="C8B82D561B6201C0" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHT6</accession>
    <name>C4YHT6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_03638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YHT6"/>
    <dbReference type="SMR" id="C4YHT6"/>
    <dbReference type="PaxDb" id="5476-C4YHT6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03638"/>
    <dbReference type="HOGENOM" id="CLU_085801_0_0_1"/>
    <dbReference type="OMA" id="IKFSRQN"/>
    <dbReference type="OrthoDB" id="37297at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875:SF2">
        <property type="entry name" value="ACR183CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875">
        <property type="entry name" value="OS09G0542200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ45318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="25262" checksum="A68B084BA2B8A6F4" modified="2010-10-05" version="1">MISPKYSATHYYLSAKALSGAKTAPHIINLYLDYNCPFSAKLFLKLYNTVIPNLEKTHPGRFQFVFVNVIQPWHTNSNLLTEFALAYAKLLREKETEVDGDIDSIKAFWDFSEKLFENKEKFYDTANIELTRNQIYEQIYNVVTSGLELKVSKEKILTELIIKPSEVPSNAGNGATADVKYFTKYLRGVGVHVTPTVSIDGIVDDSVSSGSSEDDLVKLFESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI50</accession>
    <name>C4YI50_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="5">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_03758</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="5"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI50"/>
    <dbReference type="PaxDb" id="5476-C4YI50"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03758"/>
    <dbReference type="HOGENOM" id="CLU_042344_1_2_1"/>
    <dbReference type="OMA" id="YYFIESL"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000557">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="6">
        <location>
            <begin position="5"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="7">
        <location>
            <begin position="167"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ45432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="274" mass="29045" checksum="4C61B5391626353F" modified="2009-07-28" version="1">MKDYTITVLGCGVMGTAVTSAILKSKFDPYPKKIIACTIPSQEQSLKETFADQPLVHVSAGVENNNKAVTEADVIILGCKPYMYEGIYEEVKESLTGKQLLISLLAGTTIKELSIFTPYVAKVMTNTPARFGCGTAAIAFAPEVSEESQELVMKLIDTVGMTVKIPEKNMDIATSLIGSGPAFCLLMMESMIDGAVRMGMPYDVASVAAAKVMEGTARMVLETGEHPAALKSKVCTPGGTTIGGLLTMEDRGLRSAIARGVEEAANISASFAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI59</accession>
    <name>C4YI59_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxisomal targeting signal receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Peroxin-5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAWG_03768</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins. PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts (via WxxxF/Y and LVxEF motifs) with PEX14; promoting translocation through the PEX13-PEX14 docking complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI59"/>
    <dbReference type="PaxDb" id="5476-C4YI59"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03768"/>
    <dbReference type="HOGENOM" id="CLU_013516_3_0_1"/>
    <dbReference type="OMA" id="WEEQFKQ"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005052">
        <property type="term" value="F:peroxisome matrix targeting signal-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000218">
        <property type="entry name" value="Peroxisomal targeting signal receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF0">
        <property type="entry name" value="GH08708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0882">Thioester bond</keyword>
    <keyword evidence="9 18" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="13" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="repeat" description="TPR" evidence="18">
        <location>
            <begin position="329"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="18">
        <location>
            <begin position="439"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="18">
        <location>
            <begin position="473"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00046106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEQ45441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="591" mass="67150" checksum="068C992DE32C7752" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI64</accession>
    <name>C4YI64_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_03773</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI64"/>
    <dbReference type="PaxDb" id="5476-C4YI64"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03773"/>
    <dbReference type="HOGENOM" id="CLU_032568_0_0_1"/>
    <dbReference type="OMA" id="IYCYTES"/>
    <dbReference type="OrthoDB" id="3944240at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF28">
        <property type="entry name" value="FRP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="270"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ45446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="554" mass="64705" checksum="DBAEAF1F43D7FA25" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI86</accession>
    <name>C4YI86_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI86"/>
    <dbReference type="PaxDb" id="5476-C4YI86"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04158"/>
    <dbReference type="HOGENOM" id="CLU_1372020_0_0_1"/>
    <dbReference type="OMA" id="CAYQSTN"/>
    <dbReference type="OrthoDB" id="4024213at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944243" evidence="1">
        <location>
            <begin position="23"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="222" mass="25635" checksum="CE85497038DA6466" modified="2009-07-28" version="1">MFRNKKFYFLLIFALYYTKLKLTHLMSNNPVLMKQYVQNIFSKLQIFFNRYSIPHTTNNVFEHNRLFSREGLVSCLEDSVDEIPNHLTTSTSIDLGTSEFYNSSTIDTTHNENPNPSISIEQICSMIDEELEIINEHDLNNRLESRGSFLTISRQMNMLGFPTLPRSQPCAYQSTNQNLWNVKSILPHTTGSALSINSAATPKKKKMIKIIKSKKKRVQTAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIH7</accession>
    <name>C4YIH7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial morphogenesis protein SLD7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_04252</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle pole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SLD7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIH7"/>
    <dbReference type="PaxDb" id="5476-C4YIH7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04252"/>
    <dbReference type="HOGENOM" id="CLU_068936_0_0_1"/>
    <dbReference type="OMA" id="DIQLWST"/>
    <dbReference type="OrthoDB" id="4063051at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041260">
        <property type="entry name" value="Sld7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041564">
        <property type="entry name" value="Sld7_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18596">
        <property type="entry name" value="Sld7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18636">
        <property type="entry name" value="Sld7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sld7 N-terminal" evidence="11">
        <location>
            <begin position="13"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Sld7 C-terminal" evidence="10">
        <location>
            <begin position="189"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ45912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="274" mass="31210" checksum="33893A4FCE52FC3F" modified="2009-07-28" version="1">MNYLTTIQLYESKKNVINDIQLWSTNKTLKLPTITSCKPISYIKYASLPFYLVYCCPITVYTDDSDTSDYFKTKLVETPLLSNGKSGGGGIGLLCKVDVNTFLVFYYEDNVKMLVLKFSKFIETLPQLDIPSIPKDTLLDLKPSKRIRTNTKIIDKIIEKKKQRSNSFIANPNTTKANISSGSSILTNQDQINTAINKIIFSGLRIRGLSSNVASSLNDKLTIKEIHQMTFKATQFALRKHNYSFNKRETKKPLRLNDLQDIIENLLQLFVDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIH9</accession>
    <name>C4YIH9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Early meiotic induction protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_04254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIH9"/>
    <dbReference type="PaxDb" id="5476-C4YIH9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04254"/>
    <dbReference type="HOGENOM" id="CLU_114639_0_0_1"/>
    <dbReference type="OMA" id="QREKFWF"/>
    <dbReference type="OrthoDB" id="2017405at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ45914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="17879" checksum="2C09CC0BD48247D2" modified="2009-07-28" version="1">MSKDDKDLEEIWKLFQDSNEDVQKRRKEITKAIQKDTNLNEYPGSVSMMTALDELIACFALGGQVKNYYRYGTYDSCTRQREKFWFAIKHGSFREQEERPLEELSERELTNRIKVQEFYKKRFLEDKAKGSSEDIWNKREELLSNPFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIT8</accession>
    <name>C4YIT8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endoribonuclease YSH1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Endoribonuclease ysh1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">mRNA 3'-end-processing protein YSH1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAWG_04366</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ46023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIT8"/>
    <dbReference type="PaxDb" id="5476-C4YIT8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04366"/>
    <dbReference type="HOGENOM" id="CLU_009673_2_3_1"/>
    <dbReference type="OMA" id="CKQHITL"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16292">
        <property type="entry name" value="CPSF3-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000001">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000004">
        <property type="entry name" value="Cleavage and polyadenylation specifity factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01098">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="16">
        <location>
            <begin position="25"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="17">
        <location>
            <begin position="257"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term" evidence="18">
        <location>
            <begin position="547"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="510"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="514"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEQ46023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="783" mass="87727" checksum="3372C8F6CA70560C" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJH4</accession>
    <name>C4YJH4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_03989</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJH4"/>
    <dbReference type="PaxDb" id="5476-C4YJH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03989"/>
    <dbReference type="HOGENOM" id="CLU_038177_0_1_1"/>
    <dbReference type="OMA" id="NRKMCII"/>
    <dbReference type="OrthoDB" id="10251371at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15845">
        <property type="entry name" value="SNARE_syntaxin16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF83">
        <property type="entry name" value="SYNTAXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="279"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="375"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ45658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="424" mass="49589" checksum="CCE2F8CAE9D5DF6A" modified="2009-07-28" version="1">MFRDRTNLFLSYRRTIPRDSFPTRRTRFSDLNNEEENEGLILSSTTGNQSNRKSKNKSNLKQGVNDLDNDDYEDNIELKPMIPNIFDIAKELDSYLNIINKDIEELNSMYKKLIIINKLNKLKLEKQIEEINYQILIKFEKCYVLIKKFEYLSNNHQRLKLNYNQQDLEILINFKKNYAVKIQDKSLIFRNLQNNYMKFLKNDDEDEDDEEEKEEEEEEDILNMNDEQATLLNEGNDSKSTTPRTTTTTTTTNFTNQQQQQQQVQVQLQLQHQQGNNNIQYLQQREREISKLAHGIIEISTIFKEMESMVIEQGTILDRIDYNLVNTVQDLKQADKELIKAHHYQKRSTKCKIIFFLSLCVFALLMIFILRPTKTTSPSNDSNSNSNSNSGNPGNPGNNNDQEPTRPNIDKPANEVNPPPVNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJL5</accession>
    <name>C4YJL5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04032</name>
        <name evidence="8" type="ORF">CAWG_04062</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2006-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Giovannoni S.J."/>
                <person name="Cho J.-C."/>
                <person name="Ferriera S."/>
                <person name="Johnson J."/>
                <person name="Kravitz S."/>
                <person name="Halpern A."/>
                <person name="Remington K."/>
                <person name="Beeson K."/>
                <person name="Tran B."/>
                <person name="Rogers Y.-H."/>
                <person name="Friedman R."/>
                <person name="Venter J.C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">WO-1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJL5"/>
    <dbReference type="PaxDb" id="5476-C4YJL5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04032"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04062"/>
    <dbReference type="HOGENOM" id="CLU_017584_4_0_1"/>
    <dbReference type="OMA" id="PRDFKLC"/>
    <dbReference type="OrthoDB" id="2414662at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000024">
        <property type="entry name" value="Kynurenine--oxoglutarate transaminase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051326">
        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF20">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="60"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ45699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ45728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="453" mass="51292" checksum="DA78827707180E34" modified="2009-07-28" version="1">MLRRLFPIRQLYTTTRAMASKSTDPTSLHNPYFYQKPGQKDIWSLINETAAQAQQESGEPIVNLGQGFFSYNPPEFAINAVEEALTKPQFNQYAHARGNPNLLKQVAEHYSRSYGRAVGVDEVQITTGANEGMFAIFFGFLTPGDEVIVFEPFFDQYIPNVEMTGAKIKYVEIKYPKKFDNEVVTGQDWEIDWEGLNNAITDKTKIIVINTPHNPIGKVFTEEELYKIGKLAVEHNLILVSDEVYENLYYTDKFPRPAALPQLPELAERTLTVGSAGKSFAATGWRVGYIQGPANLIKFVTAAHTRICFSTPAPLQQAVSQGFEQAEKSNYFENTRKEYEHKYKIFTKVFDDLGLPYTIAEGGYFVLVNLSKVKIPADYEFPRTISDRGTLDFKLAYWLIKEIGVVGIPPTEFLTESNRKGNGLENCVRFAVCKDDSVLEDAVERLKKLKDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK22</accession>
    <name>C4YK22_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_05817</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="2"/>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK22"/>
    <dbReference type="PaxDb" id="5476-C4YK22"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05817"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_3_1"/>
    <dbReference type="OMA" id="IKWPAYF"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010607">
        <property type="term" value="P:negative regulation of cytoplasmic mRNA processing body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="134"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="389"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="11"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="13"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ47251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="444" mass="50717" checksum="F762DE8412A30B18" modified="2009-07-28" version="1">MVNLLKKLHITKSHQSNHSNSDSNSLNSNTSMDNHQQQQQLQHQQYQQQFQQPQQQLYPGEQIVHPAAAQTGQNTTNVTAVSSSNITQSATSSLHSQQLQHVDVSKSAAEEAIRRSLLPERSTVSKGKYSLTDFSIMRTLGTGSFGRVHLVRSVHNGRYYAIKVLKKHQVVKNEQSEHTNDERRMLKLVEHPFLIRMWGTFQDSKNLFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVTLALEYLHSHDIIYRDLKPENILLDRNGHIKITDFGFAKEVSTVTWTLCGTPDYIAPEVITTKPYNKSVDWWSLGVLIFEMLAGYTPFYDSTPMKTYEKILAGKIHYPSFFQPDVIDLLTKLITADLTRRLGNLINGPADIRNHPWFSEVVWEKLLAKDIETPYEPPITAGVGDSSLFDHYPEEQLDYGSQGEDPYASYFLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK32</accession>
    <name>C4YK32_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-complex protein 1 subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_05827</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK32"/>
    <dbReference type="SMR" id="C4YK32"/>
    <dbReference type="PaxDb" id="5476-C4YK32"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05827"/>
    <dbReference type="HOGENOM" id="CLU_008891_7_2_1"/>
    <dbReference type="OMA" id="SHPQMPH"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03339">
        <property type="entry name" value="TCP1_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000003">
        <property type="entry name" value="T-complex protein 1 subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000049">
        <property type="entry name" value="T-complex protein 1 subunitTheta, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012718">
        <property type="entry name" value="Chap_CCT_epsi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02343">
        <property type="entry name" value="chap_CCT_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ47261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="548" mass="59836" checksum="5110128D6F7940A8" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK85</accession>
    <name>C4YK85_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_05882</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YK85"/>
    <dbReference type="PaxDb" id="5476-C4YK85"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05882"/>
    <dbReference type="HOGENOM" id="CLU_026996_5_2_1"/>
    <dbReference type="OMA" id="VWKIPRI"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09251">
        <property type="entry name" value="AP-2_Mu2_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14836">
        <property type="entry name" value="AP2_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043532">
        <property type="entry name" value="AP2_Mu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043512">
        <property type="entry name" value="Mu2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0168">Coated pit</keyword>
    <keyword evidence="2" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="9">
        <location>
            <begin position="214"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ47314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="470" mass="53805" checksum="58CAA143A607CBC9" modified="2009-07-28" version="1">MITAIFIYDSKGDILISKLYKDGIKRNISDVFRIQVISQTSTNRAKEYRSPVLTLGSTSFIYIKSGKIWITAVTRSNQDCSLIMEFLYKLEALLRTVLGRDKKKQLMELTDNYIINNFALCYEILSEVCEFGFPINLDLNYLKKYIDDINVDDSIFKIAPLKRRSTINPLLSKSITSGNANTTSNNNNSSNSSLKRSSAEENITWRSSGIKYRRNEIFLNVTERVNVLMNSQSDVLNAYVDGSIQMKTHLSGMPLCRFGFNDNTILLSNDEPRDGAVTLEDSKFHQCVQLNVFETERAIQFVPPDGEFQLMSYNCNSNINVPFKVYPQVQEIGRSKLMYKIRIKSFFPEKLPATNVSLKIPTPRGGTILSNLSSSIGKTKFHPEDNSISWKCNKFFGEQEHVLTAEIEVNSSSDELLYWTRPPIKLDFFLDMFSSSGLTVKFLRVQEKNNYRTVKWVKYGTQSGSYEIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKP3</accession>
    <name>C4YKP3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_06049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKP3"/>
    <dbReference type="PaxDb" id="5476-C4YKP3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06049"/>
    <dbReference type="HOGENOM" id="CLU_1408559_0_0_1"/>
    <dbReference type="OMA" id="IQGSMAD"/>
    <dbReference type="OrthoDB" id="5398685at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="190" mass="21437" checksum="97A7401389105122" modified="2009-07-28" version="1">MTQDIQGSMADAFKYLNDAEKQAANLEKMLDAFEAKLDSILKDAENINKPDEAEHQNGYEDDVEHTDENENENENEGDNEEEEEEEGEEEGDDDEEEENTKDKSNGKEDIDRNKDSKEDNSNANSTQAVQNKSETKLKENEHSDEKSDPTKENSKDGKVSKENTTNANDSINEKLTTDDEPIVPTTKSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKQ2</accession>
    <name>C4YKQ2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Luciferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_06058</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKQ2"/>
    <dbReference type="PaxDb" id="5476-C4YKQ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06058"/>
    <dbReference type="HOGENOM" id="CLU_022256_0_0_1"/>
    <dbReference type="OMA" id="SWRGDEI"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF16">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="6">
        <location>
            <begin position="43"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ47481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="403" mass="44808" checksum="A558BFF41AF25AC2" modified="2009-07-28" version="1">MTISPNKRQKRDSSSPKKHLILNAFDMMCPSLQTAGLWSHPEDKSRDYNTIEYWTNLAKLLEKGKFNALFIADVLGGYDVYNGPRNLTAAAKSGAQWPINDPHAIVPAMAAVTENLSFAITSSTVSESPYHFSRRLATLDHLTKGRIGWNIVSSYLDSAARNLLNGGPLPEHDERYVKAQEFVEVVYQLFLSSWADDAVKFDRKTRVFTDPERIREINYKGEHFIVPGPSITEPTPQRLPVILQAGASKKGLEYAAKNAEAAFINGMTPEALKVKIDQLKKLVKQHGRNPDDVKVLSLVTVIVAPTHEEAIAKYEEYKYYSNPEGAQALFGGWTGIDLGKYDYDEPLDQVESNAVRSFVESWTKPVPGEDPNTKKTRATVVNQLQIGGSGILIVGDPEEVTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKQ8</accession>
    <name>C4YKQ8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Required for respiratory growth protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_06064</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for respiratory activity and maintenance and expression of the mitochondrial genome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRG9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKQ8"/>
    <dbReference type="PaxDb" id="5476-C4YKQ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06064"/>
    <dbReference type="HOGENOM" id="CLU_1635146_0_0_1"/>
    <dbReference type="OMA" id="WYSCYST"/>
    <dbReference type="OrthoDB" id="5578174at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010487">
        <property type="entry name" value="NGRN/Rrg9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475:SF3">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ47487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="162" mass="18942" checksum="97683C98D3C7FE78" modified="2009-07-28" version="1">MIKQLLISPSCKILPTNRFIYNWYSCYSTNKPRKSIESNQKKSTTTTTSTPTPTSTSTSSSKSQSPTTDQILFEQFQKSVIKNDIKHNPNNQPFWMKRNRTIKSKHSHWNPTKKLSRSEMNKLRELKQYFPHFTTADLGKIFHISPESVRRILKSKYIPDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKR6</accession>
    <name>C4YKR6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-1,6-mannanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_06073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKR6"/>
    <dbReference type="PaxDb" id="5476-C4YKR6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06073"/>
    <dbReference type="HOGENOM" id="CLU_034119_0_0_1"/>
    <dbReference type="OMA" id="AAINSTW"/>
    <dbReference type="OrthoDB" id="9984024at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944297" description="Alpha-1,6-mannanase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="46438" checksum="CF27D8D649F71EDE" modified="2009-07-28" version="1">MQQFLRFILLLLSLISYTTFALTISTTKFAKRGSLPSSSSFDPHDAFEAAINSTWSIFWNDTNQGFSQSDPSCPNSQTSTPFQYSVVWSVAVAGMAIVQSGDISKTNQIITSLYKYQNSQGWFSATPGGGESFVDDNCQVLWVFIEAYELTNNTKYLTTANKLMELIQGQWSDKVGGVKWQVDGDYIASISTVEAALCAVQLYEQNKDDSLLSFAKKCLSWLDDNLLDKSDGFYYDGLNVNNKTNIDKGKLTYTVGVAISTYSYLYKYTNDEQYVLIATAKANETIKSTTFMRSNGYWNNDLKYLHLLFVGIVDLIIIMGDEKSDFSNDIMKQGEFIYKYDQLSEIGNYLDFTGVKQLYDQYVKQSGDNSSINYQFNGDDYCDGSNDSGQIKRSLMENASAAQIFYQLNRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKT7</accession>
    <name>C4YKT7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="9">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_06095</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
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        <reaction evidence="4 9">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
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    <dbReference type="AlphaFoldDB" id="C4YKT7"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="glycerol3P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR11728:SF8">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="10">
        <location>
            <begin position="52"/>
            <end position="217"/>
        </location>
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    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="11">
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            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
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            <position position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="57"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="7">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
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        <location>
            <begin position="326"/>
            <end position="327"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="7">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ47516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="403" mass="43808" checksum="3D2BF3C9D684781D" modified="2010-10-05" version="1">MYTTANNRLTQLTQILSPIVNDADSSFAQYLLQNPTFAPNPESSLNPEKPFKIAVVGSGNWGTTIAKIVAENALARPHLFSHYVNMWVFEEKINGENLTQIINQRHENIKYLPGVKLPNNLIAQPDIVTAVKGADLIIFNLPHQFLPKILKQLKGNVPKTTRAISCLKGLEVSKDGCKLLSTYITEELGIVCGALSGANLAPEIARGKWSETTVAYKLPNDYRGAGKDIDKLVLKACFHRPYFHVNVIEDVAGVSVAGALKNIVALAVGFVEGLGWGDNAKAAIMRVGLLETIKFSETFFPQSQADTFTAESAGVADLITTCAGGRNVKVGRYMAETGVSAEEAEKKLLNGQSSQGIVTAKEVHELLTYVNKLEEFPLFEATYQIAFGSESIENLPNLLNTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKX4</accession>
    <name>C4YKX4_CANAW</name>
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        <recommendedName>
            <fullName evidence="8">DUF803-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_06133</name>
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    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000001429">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF85">
        <property type="entry name" value="DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G15880)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="98"/>
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            <end position="125"/>
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            <end position="161"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="193"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="230"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ47553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="40197" checksum="DCF12C611B69252D" modified="2009-07-28" version="1">MEDKYIGLALAMSSSLAIGTSFIITKKGLMDASARTGGTDGVQASDYLQNPIWWGGMITMAIGEIANFAAYTFAPAILVTPLGALSVIIGAVLAAIFLKERLGTLGKMGCAICLMGSVIIILHAPPDKEVQTVDEILGYATQPGFMFYCTVVTLYSLFMIYKIVPKYGNTNPIIYLSICSSVGSISVMSIKAFGIALKLTLGGNNQFTHVSTYLFLIVVALCIVTQMNYFNKALDQFDTSIVNPLYYVTFTTFTLAASFILFKGFNTSSAVDIISLLIGFLIIFSGVYLLNISRSESPMVDRDREIFGVHTSKDMAPLDNGVGGFSTVRRSMQINRTSEYDNEESVGLRRFDSFEIDSGDEDTRNYRH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-10-19" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YL11</accession>
    <accession>O14462</accession>
    <accession>Q5A994</accession>
    <name>SEC4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>Ras-related protein SEC4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SEC4</name>
        <name type="ORF">CAWG_01525</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Yeast" volume="14" first="675" last="680">
            <title>Isolation and characterization of the Candida albicans SEC4 gene.</title>
            <authorList>
                <person name="Clement M."/>
                <person name="Fournier H."/>
                <person name="de Repentigny L."/>
                <person name="Belhumeur P."/>
            </authorList>
            <dbReference type="PubMed" id="9639314"/>
            <dbReference type="DOI" id="10.1002/(SICI)1097-0061(199805)14:7&lt;675::AID-YEA252&gt;3.3.CO;2-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1999" name="J. Bacteriol." volume="181" first="7235" last="7242">
            <title>Overexpression of a dominant-negative allele of SEC4 inhibits growth and protein secretion in Candida albicans.</title>
            <authorList>
                <person name="Mao Y.X."/>
                <person name="Kalb V.F."/>
                <person name="Wong B."/>
            </authorList>
            <dbReference type="PubMed" id="10572126"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in exocytosis. Maybe by regulating the binding and fusion of secretory vesicles with the cell surface. The GTP-bound form of SEC4 may interact with an effector, thereby stimulating its activity and leading to exocytotic fusion. SEC4 may be an upstream activator of the 19.5S SEC8/SEC15 particle. SEC4 probably interacts directly with SEC8; it could serve as the attachment site for the SEC8/SEC15 particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="AF017183">
        <property type="protein sequence ID" value="AAC50022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF015306">
        <property type="protein sequence ID" value="AAB67974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YL11"/>
    <dbReference type="SMR" id="C4YL11"/>
    <dbReference type="PaxDb" id="5476-C4YL11"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01525"/>
    <dbReference type="HOGENOM" id="CLU_041217_23_1_1"/>
    <dbReference type="OMA" id="SKMEQNE"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030658">
        <property type="term" value="C:transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000961">
        <property type="entry name" value="Ras-related protein Rab-8B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword id="KW-0268">Exocytosis</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0636">Prenylation</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000413057" description="Ras-related protein SEC4">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Effector region" evidence="2">
        <location>
            <begin position="43"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="21"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="69"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="127"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="lipid moiety-binding region" description="S-geranylgeranyl cysteine" evidence="1">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-geranylgeranyl cysteine" evidence="1">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="210" mass="23077" checksum="4E1890D887DC6131" modified="2009-07-28" version="1">MSGKGTSSRAYDMIMKLLLVGDSGVGKSCLLLRFVEDKFNPSFITTIGIDFKIRTIESKGKRIKLQVWDTAGQERFRTITTAYYRGAMGIVLIYDVTDSRSFENVENWFQTVTQHANEDAQIFLVGNKCDDEVNRQVSKEQGQELAAKLNVPFLEASAKSNENVDSIFYELASIIQEKHVEENIGGVGGASGAGGIDVSQNNSGAKNNCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLM1</accession>
    <name>C4YLM1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_01740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLM1"/>
    <dbReference type="PaxDb" id="5476-C4YLM1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01740"/>
    <dbReference type="HOGENOM" id="CLU_324819_0_0_1"/>
    <dbReference type="OMA" id="LWHERDH"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000743">
        <property type="term" value="P:nuclear migration involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000031">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF6">
        <property type="entry name" value="DYNACTIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0243">Dynein</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="8">
        <location>
            <begin position="22"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="72"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="149"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="700"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ43502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="895" mass="103018" checksum="075854130A115A75" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLU5</accession>
    <name>C4YLU5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">40S ribosomal protein S3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_01814</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLU5"/>
    <dbReference type="PaxDb" id="5476-C4YLU5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01814"/>
    <dbReference type="HOGENOM" id="CLU_058591_2_1_1"/>
    <dbReference type="OMA" id="NKKKWMI"/>
    <dbReference type="OrthoDB" id="10248446at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.32:FF:000013">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000006">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="9">
        <location>
            <begin position="22"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="223"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ43576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="251" mass="27286" checksum="EC0106D02007E5B0" modified="2010-10-05" version="1">MVNAILSKKKKLVADGVFYAELNEFFTRELAEQGYAGVEVRKTPSKLEVIVKASNTQGVLGEQGRRIHELTSLIVKRFKLSPEGIAIYAERVEERGLSAAVQAEALKAKLLSGLPIRRAAYGVLRFAMGAGAKGVEVVISGKLRAARAKSQKYADGFMIHSGQPTRDFIDIAIRHVLMRQGVLGIKVKIMKDPAANRFGPRALPDAVKIAEAKDEDEVIPAPTVKSYKQTAEDETETEAPVEAEAEVEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLV3</accession>
    <name>C4YLV3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">low-specificity L-threonine aldolase</fullName>
            <ecNumber evidence="8">4.1.2.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_01822</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-allo-threonine = acetaldehyde + glycine</text>
            <dbReference type="Rhea" id="RHEA:26209"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58585"/>
            <dbReference type="EC" id="4.1.2.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-threonine = acetaldehyde + glycine</text>
            <dbReference type="Rhea" id="RHEA:19625"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.1.2.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid degradation; L-threonine degradation via aldolase pathway; acetaldehyde and glycine from L-threonine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.48" evidence="8"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLV3"/>
    <dbReference type="PaxDb" id="5476-C4YLV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01822"/>
    <dbReference type="HOGENOM" id="CLU_029381_1_0_1"/>
    <dbReference type="OMA" id="RAHVHCW"/>
    <dbReference type="OrthoDB" id="10261951at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000030">
        <property type="entry name" value="Low-specificity L-threonine aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000089">
        <property type="entry name" value="Threonine aldolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041359">
        <property type="entry name" value="GntG_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="11">
        <location>
            <begin position="15"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00050410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ43584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="369" mass="41407" checksum="B7F1922F4D2A16D4" modified="2009-07-28" version="1">MDFSTFDKQSPAHNDFRSDTFTTPTTSMIQSLAQTTLGDAVYNEDLKTIELEQKVAELTGKEAGLYCVSGTLSNQIAIRTNLYQPPFSVLCDYRAHVYVHEAGGLSTLSQAMAQPINPKNGIHLTLEDDILPNFIFDDGEIHGAPTKLICLENTLHGMIFPIEEIKKISKFCQQYNVKLHLDGARIWNASAETGISLKEYCSYFDSVSLCLSKTLGAPIGTVLVSDKKFILKANHFKKQNGGGIRQSGLLASMAIIAIDENFSKLKQTHIWAKELGKLCDENGIILEHPVQTNFVFIDIAANKINPEKLMEISDKYNVKIYSGRIAFHYQISQESFENAKKVVLEVIQYAKDHPYEEKTNFKFYTSENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLX2</accession>
    <name>C4YLX2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_01844</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPS family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLX2"/>
    <dbReference type="PaxDb" id="5476-C4YLX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01844"/>
    <dbReference type="HOGENOM" id="CLU_003676_2_0_1"/>
    <dbReference type="OMA" id="SDYDLNC"/>
    <dbReference type="OrthoDB" id="295029at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007587">
        <property type="entry name" value="SAPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634:SF8">
        <property type="entry name" value="FIERY MOUNTAIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634">
        <property type="entry name" value="SIT4 YEAST -ASSOCIATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04499">
        <property type="entry name" value="SAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="812"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="816"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="881"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="899"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="915"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ43603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="924" mass="104648" checksum="84C07EBA9499AEF5" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM17</accession>
    <name>C4YM17_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_01892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM17"/>
    <dbReference type="PaxDb" id="5476-C4YM17"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01892"/>
    <dbReference type="HOGENOM" id="CLU_074386_0_0_1"/>
    <dbReference type="OMA" id="IHLEYFF"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="32544" checksum="1121699EC71D56DF" modified="2009-07-28" version="1">MSSTSMDIDIFAKLAKLPSEIITIILDYLPKCILPKLLYLSPIRKIVASAILLDVEITEHVKRHERSNEPGVGFSKCDCDHMTFQPECLKQGVNQWKIFPRIIHLEYFFAFKLTYKIFSEVLYKASKVNATFFGYDSCDPDSDLKHFAESKVKFDSLTLQSCEHVSELPTVVTSLELNETILDNYEIDGLKKLILDSFGYENTTTEYSFASSLEDLTILDYKITKITLPPNLRRLYISTFSKSADFVSEEMPHLEYLSLSLPDVKSLEDTGIHAPNLKTLEINSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM88</accession>
    <name>C4YM88_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAWG_01966</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM88"/>
    <dbReference type="PaxDb" id="5476-C4YM88"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01966"/>
    <dbReference type="HOGENOM" id="CLU_010365_4_0_1"/>
    <dbReference type="OMA" id="INTYFAQ"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Probable ferric reductase transmembrane component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FAD-bd_8"/>
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        <property type="entry name" value="FAD-bd_FR_type"/>
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        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
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        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
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        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
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        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0410">Iron transport</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946625" description="FAD-binding FR-type domain-containing protein" evidence="17">
        <location>
            <begin position="21"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="417"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEQ43719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="736" mass="83910" checksum="B94CA3598FE77CE7" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMC4</accession>
    <name>C4YMC4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_02003</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="component" value="Chromosome R"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071468">
        <property type="term" value="P:cellular response to acidic pH"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071248">
        <property type="term" value="P:cellular response to metal ion"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcriptional regulator CRZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050826">
        <property type="entry name" value="Krueppel_C2H2_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24377">
        <property type="entry name" value="IP01015P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
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    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="412"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="19"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="172"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="294"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="306"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="467"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ43755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="515" mass="57330" checksum="AA02A9CA96708517" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMK9</accession>
    <name>C4YMK9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_02092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMK9"/>
    <dbReference type="PaxDb" id="5476-C4YMK9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02092"/>
    <dbReference type="HOGENOM" id="CLU_1992298_0_0_1"/>
    <dbReference type="OMA" id="THKYSQI"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="125" mass="14506" checksum="3D235CBA9FCFD975" modified="2009-07-28" version="1">MEPRLGTHKYSQISQLNAKVIMSGTWFFQSEDDFIIEFFAKYFKYIIVQSSHTLWYDNFNTPIYSCATEKTETAVISNIGCLKVFLLVAKSKYGTFQDSRWPPTTHNSVNHLPRNKWSSFTTNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMM4</accession>
    <name>C4YMM4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_02107</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMM4"/>
    <dbReference type="PaxDb" id="5476-C4YMM4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02107"/>
    <dbReference type="HOGENOM" id="CLU_021928_3_0_1"/>
    <dbReference type="OMA" id="DHNAWNP"/>
    <dbReference type="OrthoDB" id="420076at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="184"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ43855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="580" mass="64825" checksum="A5EA803FBFC3FC09" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMU3</accession>
    <name>C4YMU3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_02180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMU3"/>
    <dbReference type="PaxDb" id="5476-C4YMU3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02180"/>
    <dbReference type="HOGENOM" id="CLU_1042060_0_0_1"/>
    <dbReference type="OMA" id="FILHRIF"/>
    <dbReference type="OrthoDB" id="4011634at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="274" mass="31972" checksum="1C3BAB4BED49D012" modified="2009-07-28" version="1">MSFNRVETFILHRIFVDLNKDLFEKITQEPIVSRVKTGSKYIPYEYIVQSPTTTILKNQIAVYNAISEKIQELPITENNFELIIYGLEYQYLHLKFRTLEGKDVVDIIGYVISTSDGKFGITNLVESIQLIIDPKLRVVVDDFASFTKTFPNLTKTSLNHALAITYAYGIFFYPVVHNVLNCTKNVKLMRDFMRYYYLRYLQNPNDEFIDITQEAYNFCKENFPNDIEQKTNQVIDEMTLSVLSSTLGLLDSLETSKLEYKQRRIGYQYTRGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMZ4</accession>
    <name>C4YMZ4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-D1-binding protein 1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_02231</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMZ4"/>
    <dbReference type="PaxDb" id="5476-C4YMZ4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02231"/>
    <dbReference type="HOGENOM" id="CLU_067849_0_0_1"/>
    <dbReference type="OMA" id="WIDTWEI"/>
    <dbReference type="OrthoDB" id="4088536at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026907">
        <property type="entry name" value="GCIP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049317">
        <property type="entry name" value="GCIP-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492">
        <property type="entry name" value="CYCLIN D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492:SF1">
        <property type="entry name" value="CYCLIN-D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13324">
        <property type="entry name" value="GCIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like N-terminal" evidence="3">
        <location>
            <begin position="52"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ43975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="390" mass="45044" checksum="7E0495EAA2048DE1" modified="2009-07-28" version="1">MTKPELKTQNDLKNLLQSFKQATEFWIQSININKFDEINGFTTTTIDNPQQELIKLIKLIKAHTTKVGIIFKPTNLFKDPNVAYNTLEELSETLVLTISIINQLENEQQEEEEAEANKEQKKISKISKIFYDEIIDQIKLLFSSIIELNQELIIIINNENEKDKTNEDGEDNDDDDAGRLISVGKIWSNCDSLDQLLNEGDLGLLTTKIKQSISLLDDGFEEFVTWANNPEEIEDDPFGFSDDEEEEEEEEQDDDNDNDSLHSIIDTKELSEFANKWVKKIELIKLLISSFKKSSLPPPLKANPNSISGNTIDEINNLQSNLVQLIDNFIIDLMIDRNIHDDEIIRYTNRIINQAIKLSELAMIIYNHQPLTNYEKKLKWYETFINKISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNA4</accession>
    <name>C4YNA4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ44085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNA4"/>
    <dbReference type="PaxDb" id="5476-C4YNA4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02344"/>
    <dbReference type="HOGENOM" id="CLU_067134_0_0_1"/>
    <dbReference type="OMA" id="INDMQND"/>
    <dbReference type="OrthoDB" id="4092858at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021017">
        <property type="entry name" value="Mediator_Med2_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11214">
        <property type="entry name" value="Med2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="29575" checksum="5C992BB432925554" modified="2009-07-28" version="1">MPENLQTRLHNSLDEILKSSGYIFEIIDQNRKQSNVITSPNNELIQKSITQSLNGEIQNFHAILDQTVSKLNDAEWCLGVMVEKKKKLDELKVKEEAARKKEEGAKKKEEEAKKKEEEAKKKAEEAKKKAEEAKKAEEAVPQKFDNFDDFIGFDINDMQNDDTIDDTIDDTIDETIDETIDDTNDEDMLSNMDYENLDPDETIDEVPATTDSDLDMNNILENNESILDGLNMTFLDNGNNTNHVNEEFDVDGFLNQFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNE2</accession>
    <name>C4YNE2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWR1-complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_01401</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNE2"/>
    <dbReference type="PaxDb" id="5476-C4YNE2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01401"/>
    <dbReference type="HOGENOM" id="CLU_018539_4_0_1"/>
    <dbReference type="OMA" id="GNTTMYQ"/>
    <dbReference type="OrthoDB" id="19740at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008468">
        <property type="entry name" value="DMAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05499">
        <property type="entry name" value="DMAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="299"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="148"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="192"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="263"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ43175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="635" mass="73999" checksum="7BB9E7C363FD28CD" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNK5</accession>
    <name>C4YNK5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">3-keto-steroid reductase ERG27</fullName>
            <ecNumber evidence="14">1.1.1.270</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">3-keto-steroid reductase erg27</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CAWG_01467</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Facilitates the association of ERG7 with lipid particles preventing its digestion in the endoplasmic reticulum and the lipid particles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>3-dehydro-4alpha-methylzymosterol + NADPH + H(+) = 4alpha-methylzymosterol + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:36379"/>
            <dbReference type="ChEBI" id="CHEBI:1949"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:136486"/>
            <dbReference type="EC" id="1.1.1.270"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:36380"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="12">Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 5/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Heterotetramer of ERG25, ERG26, ERG27 and ERG28. ERG28 acts as a scaffold to tether ERG27 and other 4,4-demethylation-related enzymes, forming a demethylation enzyme complex, in the endoplasmic reticulum. Interacts with ERG25 and ERG28. Also interacts with ERG7, but only in lipid particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.270" evidence="14"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNK5"/>
    <dbReference type="PaxDb" id="5476-C4YNK5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01467"/>
    <dbReference type="HOGENOM" id="CLU_029944_1_0_1"/>
    <dbReference type="OMA" id="WHNIDGY"/>
    <dbReference type="OrthoDB" id="9989144at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000253">
        <property type="term" value="F:3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000525">
        <property type="entry name" value="3-keto-steroid reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051593">
        <property type="entry name" value="Ergosterol_Biosynth_ERG27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647:SF1">
        <property type="entry name" value="3-KETO-STEROID REDUCTASE ERG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647">
        <property type="entry name" value="DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00065763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00071092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00072263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EEQ43238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="346" mass="39021" checksum="0E6F2A611273EF68" modified="2009-07-28" version="1">MSLLKDSTVAVITGTSSNLGFNIAVRLLEGLPDNKEITLVVTSRTLPKVKEVISDIKKYIVAKIPTKVNKVEFDYLLVDFTDMVSILSAYYELNKRYKHIDYLFINAAQGVYGGIDWTGAVLEVLQSPIEAVTNPTYKLQKVGVESGDKLGLVFQANVFGPYYFIHRIKHLLENGGKIVWISSLMSSPKYLSFNDLQLLRSPASYEGSKRLVDLMHFGTYNKLEREYGIKQYLVHPGIFTSFSFFQYLNVFTYYGMLFLFYLARFLGSPYHNISGYIAANAPVAAALGQTKQNCKTASACTRSGKEYLLEEEIDSTGSDDVVSYLDTLTKEWDEKLKDQIVNTRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNK9</accession>
    <name>C4YNK9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">F-actin-capping protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_01471</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the F-actin-capping protein alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNK9"/>
    <dbReference type="PaxDb" id="5476-C4YNK9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01471"/>
    <dbReference type="HOGENOM" id="CLU_045161_3_0_1"/>
    <dbReference type="OMA" id="VACIEDH"/>
    <dbReference type="OrthoDB" id="340550at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000014">
        <property type="entry name" value="F-actin-capping protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.60">
        <property type="entry name" value="F-actin capping protein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002189">
        <property type="entry name" value="CapZ_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042489">
        <property type="entry name" value="CapZ_alpha_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017865">
        <property type="entry name" value="F-actin_cap_asu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01267">
        <property type="entry name" value="F-actin_cap_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00191">
        <property type="entry name" value="FACTINCAPA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00749">
        <property type="entry name" value="F_ACTIN_CAPPING_A_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0117">Actin capping</keyword>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ43242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="280" mass="31998" checksum="DD6672D87D7CA9A1" modified="2009-07-28" version="1">MSIKLNELVDSLIQSAPPAELKQVSQSLSSLTKGTSTSSTNSLIQDSIEQYAQENIISIDNIIISKYNKDENSSKYIDYVNNKLFNVDWQNQKIIDVESYHDNNNKRGSNYDELIQKLSQYGDDYYPSNFAFTVIPESEDQLRVIIIGQRANHDNFYTGQWKSNYLITEQGIKGNIDLDIHYFEDGNVRLKFNESINSSNNNNNSSTLQSGNLINNASRIVNFINEQENATMVKIIEQFNNLNQKSFKNLRRLLPVTRSKINWGSAIGNYRLGSDVINKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YP23</accession>
    <name>C4YP23_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein ECM15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_02958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YP23"/>
    <dbReference type="SMR" id="C4YP23"/>
    <dbReference type="PaxDb" id="5476-C4YP23"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02958"/>
    <dbReference type="HOGENOM" id="CLU_137479_0_0_1"/>
    <dbReference type="OMA" id="KYKMHGY"/>
    <dbReference type="OrthoDB" id="5587367at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051614">
        <property type="entry name" value="UPF0045_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00106">
        <property type="entry name" value="MTH1187 family thiamine-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777:SF1">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="MTH1187/YkoF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine-binding protein" evidence="2">
        <location>
            <begin position="9"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ44682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="112" mass="12361" checksum="2FFBE725795E7EA8" modified="2009-07-28" version="1">MAVTLHCLADICLIPIGTNSSSVSDEITAITKLARDSPLETTLHSAGTTIAGPWDQVMDLIGQMHQLLHEKHGVVRIQSDIRVGTRVDKPNQLPQDKINVVQRKLAQQEKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPD6</accession>
    <name>C4YPD6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">fructose-bisphosphatase</fullName>
            <ecNumber evidence="5">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">D-fructose-1,6-bisphosphate 1-phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_03089</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the FBPase class 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="5"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPD6"/>
    <dbReference type="SMR" id="C4YPD6"/>
    <dbReference type="PaxDb" id="5476-C4YPD6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03089"/>
    <dbReference type="HOGENOM" id="CLU_039977_1_0_1"/>
    <dbReference type="OMA" id="YIPENCP"/>
    <dbReference type="OrthoDB" id="10256725at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005986">
        <property type="term" value="P:sucrose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000009">
        <property type="entry name" value="Fructose-1,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556:SF1">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class I N-terminal" evidence="13">
        <location>
            <begin position="19"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class 1 C-terminal" evidence="14">
        <location>
            <begin position="210"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ44795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="331" mass="35932" checksum="DA1AEC87CE13A3F7" modified="2010-10-05" version="1">MSGPVNSVSKQMNVDTDIITLTRFILQEQQTVAPTATGELSLLLNALQFAFKFIAHNIRRAELVNLIGVSGSANSTGDVQKKLDVIGDEIFINAMRSSNNVKVLVSEEQEDLIVFPGGGTYAVCTDPIDGSSNIDAGVSVGTIFGVYKLQEGSTGGISDVLRPGKEMVAAGYTMYGASAHLALTTGHGVNLFTLDTQLGEFILTHPNLKLPDTKNIYSLNEGYSNKFPEYVQDYLKDIKKEGYSLRYIGSMVADVHRTLLYGGIFAYPTLKLRVLYECFPMALLMEQAGGSAVTIKGERILDILPKGIHDKSSIVLGSKGEVEKYLKHVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPK3</accession>
    <name>C4YPK3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_02404</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPK3"/>
    <dbReference type="PaxDb" id="5476-C4YPK3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02404"/>
    <dbReference type="HOGENOM" id="CLU_007090_2_0_1"/>
    <dbReference type="OMA" id="TIMMEED"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000221">
        <property type="term" value="P:negative regulation of pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22701">
        <property type="entry name" value="FHA_FKH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000147">
        <property type="entry name" value="Fork-head transcriptional regulator 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000030">
        <property type="entry name" value="Forkhead box protein K2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF1">
        <property type="entry name" value="FORK HEAD PROTEIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="82"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="9">
        <location>
            <begin position="252"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="252"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="385"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="476"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="412"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="476"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ44142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="527" mass="59138" checksum="7809374D586AF736" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ20</accession>
    <name>C4YQ20_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Presequence translocated-associated motor subunit PAM17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_02574</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the PAM complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the PAM17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ20"/>
    <dbReference type="PaxDb" id="5476-C4YQ20"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02574"/>
    <dbReference type="HOGENOM" id="CLU_068297_2_0_1"/>
    <dbReference type="OMA" id="MIFGFDP"/>
    <dbReference type="OrthoDB" id="5970083at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013875">
        <property type="entry name" value="Pam17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021:SF1">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08566">
        <property type="entry name" value="Pam17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ44309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="185" mass="21078" checksum="646F84B379F4C29F" modified="2009-07-28" version="1">MFSLGVQNRLFTRRALFSGFRFNSTTTTTTTASQPRLTWVDYFQLKKQNNRINTIAGVFTGLGGAFITLSYLGNIEIDVEKPIMGFDPLMVMGGAVILGGLVGFLVGPFIGSSIFRLTNRAQLKQFELKNTEFLSRLRIKRPDPSSQSFSNPIPDYYGEKIYSLKDYKQWLRDCNAFRRKSKEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ89</accession>
    <name>C4YQ89_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear control of ATPase protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_02645</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ89"/>
    <dbReference type="PaxDb" id="5476-C4YQ89"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02645"/>
    <dbReference type="HOGENOM" id="CLU_008227_2_0_1"/>
    <dbReference type="OMA" id="NRIYHVY"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013946">
        <property type="entry name" value="NCA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234:SF1">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08637">
        <property type="entry name" value="NCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ44378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="701" mass="80720" checksum="A36A05BA2F3B40A4" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQD3</accession>
    <name>C4YQD3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_02690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. Involved in mitophagy; may act as an adapter for ATG8 that supports mitophagosome assembly. Negatively regulates the proteolytic processing of ATG32 via the i-AAA protease. Acts as a negative regulator of the m-AAA protease.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2). The subunits assemble into a membrane-associated ring-shaped supercomplex of approximately 1 mDa. The mitochondrial prohibitin complex interacts with the m-AAA protease, a heterohexamer composed of YTA12/RCA1 and YTA10/AFG3. The mitochondrial prohibitin complex interacts with ATG8 and the interaction may support mitophagosome assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQD3"/>
    <dbReference type="PaxDb" id="5476-C4YQD3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02690"/>
    <dbReference type="HOGENOM" id="CLU_047969_0_2_1"/>
    <dbReference type="OMA" id="WNITYLL"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045861">
        <property type="term" value="P:negative regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="25"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00057247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00063239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ44422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="283" mass="30867" checksum="278F3F3706ABF238" modified="2009-07-28" version="1">MSQRIADFVSKIALPVGITIALAQSALYDVPGGKRAVIFDRLKGVKQGVIGEGTHFLVPWLQKAVIFDVRVEPRVITTTTGSKDLQNVSLTLRVLSRPEVRKLPTIYQTLGLDYGERVLPAIGNEILKSIVAQFDAAELITQREVVSARIRQELSRRAAEFNIELEDVSITHMTFGREFTKAVEKKQIAQQDAERSKYLVERAEQEKKAAIIRAEGEAESADVVSKALAKAGDGLLMIRRLEASKDIASTLANSPNITYLPNGGAGGSDSDGSKNSLLLNIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQI0</accession>
    <name>C4YQI0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_02738</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQI0"/>
    <dbReference type="PaxDb" id="5476-C4YQI0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02738"/>
    <dbReference type="HOGENOM" id="CLU_024893_0_1_1"/>
    <dbReference type="OMA" id="MTSIGCF"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946716" description="WSC domain-containing protein" evidence="9">
        <location>
            <begin position="24"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="10">
        <location>
            <begin position="29"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="123"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="187"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ44469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="358" mass="37336" checksum="1CD01D0CD82F1A11" modified="2009-07-28" version="1">MVKLPFFTIVVSIFYTSSLLVSAADYTAPASNLGCYSSISGGDSKGDYTYQTSGYCVNNECPNSPYVAVKGKECICLNSLPQSSSKVSSSQCDQPCPGYQSDMCGGSNAYNVYKGLASASSSSSSNSGSASSSSPSSSGSPSSSQSSSITGSPNNSDDSDQSTATVVSTISNSNGNVIYKTITQEASATTSSGSSSHASTTSSSSSTSTSSSHSSDSPDGKSEKKSSSVGAIVGGVVGGIGGLILLVAGGFFYMRYRNNDEDEDEEEEFYDNKPLKRSNGSKIGSRRSPNALEMPMANPFQHPADDLVRNNSVQKNGFVDPRLNPIMMGRRRLSEGSLVDEADYSRKVLQVANPDDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQW1</accession>
    <name>C4YQW1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bacterial surface antigen (D15) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_04458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQW1"/>
    <dbReference type="PaxDb" id="5476-C4YQW1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04458"/>
    <dbReference type="HOGENOM" id="CLU_556813_0_0_1"/>
    <dbReference type="OMA" id="RYFNEWV"/>
    <dbReference type="OrthoDB" id="1724197at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="57391" checksum="2E74D4238D3E753C" modified="2010-10-05" version="1">MVELQVNTNPDLKSKLIEEQYLQESNNLPIYLTKIEVVGGESFSNQFFQNLLSPILQNGDLTFIQLVNKIKSSQSKLIETGIFDKVAIQILPDNFYSLSSNKIKSYNNEPSLLTKVLIDLSAINLSNNQGFFNFNNEEYLNLKLNHINHNFNGNGELISIGVDYNPYKPLDHLIANGKFISYLKNPKFKFLIDLQLNQENNETWQDTKQEIIGGKLGLLYGNSTTNDLSVFTGFQLLKRNLINLDDGNFDSIKFFNGQFLKSSILNQLKYQKIEYLHDQSKNFPKNGYELLFNGEISSNQEQLNTNNLNEFIKTDLSINLYKSLFNEFFTTKFQAQLGGIYSFNNNNNDSNNNNKLTPIHPSDKFYLGGYNSFPGFSKNSVELQGGDQYYKLQTTLYSKIPTLLYAPPPPSASTIGLGNEQDLNPLRIYATGIIGNVVNSSKANLLEDENGAISYGFGLKYFNNWANFDIGYFFSKRLAFNNDTNSVNTAGIKDGLHFSISIGGSNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR29</accession>
    <name>C4YR29_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_04528</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR29"/>
    <dbReference type="PaxDb" id="5476-C4YR29"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04528"/>
    <dbReference type="HOGENOM" id="CLU_320547_0_0_1"/>
    <dbReference type="OMA" id="FQVLNHK"/>
    <dbReference type="OrthoDB" id="28092at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946731" description="ER membrane protein complex subunit 1" evidence="12">
        <location>
            <begin position="19"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="830"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="13">
        <location>
            <begin position="643"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ46182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="861" mass="97144" checksum="D452779FE89D94FA" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR51</accession>
    <name>C4YR51_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-MPP</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Inactive zinc metalloprotease alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_04550</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR51"/>
    <dbReference type="PaxDb" id="5476-C4YR51"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04550"/>
    <dbReference type="HOGENOM" id="CLU_009902_5_2_1"/>
    <dbReference type="OMA" id="LKYHHSP"/>
    <dbReference type="OrthoDB" id="277191at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000023">
        <property type="entry name" value="Mitochondrial processing peptidase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="9">
        <location>
            <begin position="55"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="10">
        <location>
            <begin position="206"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ46204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="522" mass="58212" checksum="16B8147298662FD4" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR64</accession>
    <name>C4YR64_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_04563</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR64"/>
    <dbReference type="PaxDb" id="5476-C4YR64"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04563"/>
    <dbReference type="HOGENOM" id="CLU_091806_1_0_1"/>
    <dbReference type="OMA" id="RISMQKV"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="110"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ46217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="167" mass="19650" checksum="7C436C0838216190" modified="2009-07-28" version="1">MNSHSEALFEINQRLSSHIRTMSNFPVFDPQKITNDVEANIKRMTSILKSKRLTREDEDLMKMINDCSKVLHEMLLERIMLQQDSIQFFTEKEASDSPFSNSADTIDEDDDKKIKSRRLTKKQLLVLEGWFQKHKNHPYSQKDQTNLLIKSTKLSKSQVQNWYVSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR93</accession>
    <name>C4YR93_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein ESF2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">18S rRNA factor 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pre-rRNA-processing protein esf2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_04592</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF2/ABP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR93"/>
    <dbReference type="PaxDb" id="5476-C4YR93"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04592"/>
    <dbReference type="HOGENOM" id="CLU_054086_0_0_1"/>
    <dbReference type="OMA" id="TRKHNDF"/>
    <dbReference type="OrthoDB" id="287393at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12263">
        <property type="entry name" value="RRM_ABT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000825">
        <property type="entry name" value="Pre-rRNA-processing protein ESF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034353">
        <property type="entry name" value="ABT1/ESF2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="272"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ46246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="320" mass="36798" checksum="7287346310C1AFA9" modified="2009-07-28" version="1">MSATSDRESDFESEDENNFQDKVFNVKSKTSSFFHANTSDNEDFSEDEEDKDEQDEGDTKTKPKDGKHNFEDIAYDEESEENIGDDEDGNADLSLDGGSKVNKKLKKLTSKELAKEQKRIKRTGVCYLSRVPPYMKPAKLRSVLSRFGEIDRLFLKPEDPSVYHKRVKYGGNKKKNFTEGWIEFVNKSDAKLCAATLNGNKLGGKKTSYYYDDIINIKYLPGFKWLDLTQQIAKENEVRQAKLAMEISQQQKLNKSFVSNVEKSKMIANIQKKRKTTDDDNIRRDFKQRKVTTTRSDAKDDLKSKSKPTDKLNDILSKVF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-10-19" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRB7</accession>
    <accession>C4YRB8</accession>
    <accession>O13431</accession>
    <accession>Q5AGD7</accession>
    <accession>Q92212</accession>
    <name>STE20_CANAW</name>
    <protein>
        <recommendedName>
            <fullName>Serine/threonine-protein kinase CST20</fullName>
            <ecNumber>2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CST20</name>
        <name type="synonym">HST20</name>
        <name type="synonym">STE20</name>
        <name type="ORF">CAWG_04616/04617</name>
    </gene>
    <organism>
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="Proc. Natl. Acad. Sci. U.S.A." volume="93" first="13217" last="13222">
            <title>Signal transduction through homologs of the Ste20p and Ste7p protein kinases can trigger hyphal formation in the pathogenic fungus Candida albicans.</title>
            <authorList>
                <person name="Leberer E."/>
                <person name="Harcus D."/>
                <person name="Broadbent I.D."/>
                <person name="Clark K.L."/>
                <person name="Dignard D."/>
                <person name="Ziegelbauer K."/>
                <person name="Schmidt A."/>
                <person name="Gow N.A.R."/>
                <person name="Brown A.J.P."/>
                <person name="Thomas D.Y."/>
            </authorList>
            <dbReference type="PubMed" id="8917571"/>
            <dbReference type="DOI" id="10.1073/pnas.93.23.13217"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">MAP4K component of the MAPK pathway required for the mating pheromone response, and the regulation of cell polarity and cell cycle. Phosphorylates histone H2B to form H2BS10ph (By similarity). Required for hyphal formation and virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="7">
        <conflict type="erroneous termination">
            <sequence resource="EMBL-CDS" id="EEQ46270" version="1"/>
        </conflict>
        <text>Truncated C-terminus.</text>
    </comment>
    <comment type="sequence caution" evidence="7">
        <conflict type="erroneous termination">
            <sequence resource="EMBL-CDS" id="EEQ46271" version="1"/>
        </conflict>
        <text>Truncated C-terminus.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1"/>
    <dbReference type="EMBL" id="L47210">
        <property type="protein sequence ID" value="AAB65439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46271.1"/>
        <property type="status" value="ALT_TERM"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46270.1"/>
        <property type="status" value="ALT_TERM"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T18256">
        <property type="entry name" value="T18256"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRB7"/>
    <dbReference type="SMR" id="C4YRB7"/>
    <dbReference type="PaxDb" id="5476-C4YRB7"/>
    <dbReference type="HOGENOM" id="CLU_000288_26_0_1"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000385">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000413041" description="Serine/threonine-protein kinase CST20">
        <location>
            <begin position="1"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="2">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="947"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="403"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="539"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="861"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="256"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="343"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="433"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="544"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="564"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="608"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="623"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="664"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="690"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="730"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="744"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="783"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="805"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="861"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="871"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="1067"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="953"/>
            <end position="961"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="977"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAB65439." evidence="7" ref="1">
        <original>D</original>
        <variation>E</variation>
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAB65439." evidence="7" ref="1">
        <original>G</original>
        <variation>S</variation>
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAB65439." evidence="7" ref="1">
        <original>H</original>
        <variation>HNNNNNN</variation>
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAB65439." evidence="7" ref="1">
        <original>A</original>
        <variation>G</variation>
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAB65439." evidence="7" ref="1">
        <original>L</original>
        <variation>P</variation>
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="8917571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="1224" mass="132197" checksum="C835CCF4E4A859E0" modified="2011-10-19" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRN7</accession>
    <name>C4YRN7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRN7"/>
    <dbReference type="SMR" id="C4YRN7"/>
    <dbReference type="PaxDb" id="5476-C4YRN7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04739"/>
    <dbReference type="HOGENOM" id="CLU_006033_1_2_1"/>
    <dbReference type="OMA" id="NPWGLWW"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF25">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 14 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="51"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="286" mass="31431" checksum="EB8B6EB0AE4883C9" modified="2010-10-05" version="1">MSPTSTTQQPVTSRGYEIGTRGSHNIAKGGKHPYQLPKFTDKKEERKWMLQHMAAAFRVFARKGYTEGTAGHISIRDPIDPNTFWINPLGKHFGLLKASDMVHVDHEGNILPDGAQVAINAAGFSIHSALHHARPDVHAACHTHSVYGKAWSAMGKPLAMINQDVCTFYKSHAVYEDFGGVALEAEEGIHISKALGDGKGVILQNHGLLTVGNTVDEAAYLFTLLEKSCQVQLAAQAALLPGEKLKIIGDEEAAYCERNDGDPETLYTEFQPDFEMEVYLNDDFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRU2</accession>
    <name>C4YRU2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease T2</fullName>
            <ecNumber evidence="4">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CAWG_04799</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Rnase which modulates cell survival under stress conditions. Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death. Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19" evidence="4"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRU2"/>
    <dbReference type="PaxDb" id="5476-C4YRU2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04799"/>
    <dbReference type="HOGENOM" id="CLU_037966_0_1_1"/>
    <dbReference type="OMA" id="YMSEYWK"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.730.10:FF:000004">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057328">
        <property type="entry name" value="RNaseT2L_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25488">
        <property type="entry name" value="RNaseT2L_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944907" description="ribonuclease T2" evidence="17">
        <location>
            <begin position="19"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="RNase T2-like C-terminal" evidence="18">
        <location>
            <begin position="306"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR633697-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF25488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EEQ46445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="413" mass="45820" checksum="8A140B9097E0C4FD" modified="2009-07-28" version="1">MKYSILAILAHLLTNIKATQEVFTLSDLPPDSCPIDSPISCSRNAQELENVNSCCYESPAGVILLTQFWDYNPATGPDNLFTQHGLWGNMCSYGYPQFCDPSLEINPNGEIIRSIIVDQFGDEELYNNMSYSWKDYHGKDSSFWAHEYNKHGTCFSTIKPSCYLSKAPKNQNLYDFFRIAIGLFNKLPTYDWLAEAGIVPTNSKTYSLSEIQSALNDKFGANVFIKCDYNHAINEIWYYHHVKGSLLQHNFLPIDSVAHTNCPSTGIKYPPKGKIAHPTLTTKTTTGTSTTIHNPTGIPARAYVHLSKKTGCLISNGKWYTSGTCATYHFKKTINDSNIEIRSSKGICGINGNEEFTCSRAVSGGTDFQIKDGKIGYQDKFDWCFGSTTGSGSTAQTSVKLADGSCDSFQLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRV2</accession>
    <name>C4YRV2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_04809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRV2"/>
    <dbReference type="PaxDb" id="5476-C4YRV2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04809"/>
    <dbReference type="HOGENOM" id="CLU_114600_0_0_1"/>
    <dbReference type="OMA" id="MRAWYGG"/>
    <dbReference type="OrthoDB" id="10543007at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946752" evidence="2">
        <location>
            <begin position="19"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="236" mass="22873" checksum="BC3D7B7E03DE8214" modified="2009-07-28" version="1">MLFTQLIILLTVTSQALSVTISDLNNIASNQVTKRLGGGSRGGSSSGSRGGSSSGSSSGFSSGSSSGSSSGSSSGSSSGSSSGSSSGSSSGSRGGSSSGSSSSGSRGGGSGSSSSSGSRNWGSNQYHCSGNSCGYGNYYAPSAAAAAVGYGTGRYTGGTQYGNNQYHCSGSTCGYGNYFAPSAAAAAAGYGSARYYAQHHNSTSSESETISGSSSLNIPSTHFYLIGFAAAYSIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRW9</accession>
    <name>C4YRW9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein-sorting-associated protein 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_04826</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRW9"/>
    <dbReference type="PaxDb" id="5476-C4YRW9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04826"/>
    <dbReference type="HOGENOM" id="CLU_087657_0_1_1"/>
    <dbReference type="OMA" id="TRCLIMW"/>
    <dbReference type="OrthoDB" id="245150at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.570:FF:000011">
        <property type="entry name" value="ESCRT-II subunit protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ46472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="22755" checksum="FE5BE8CDD369704F" modified="2009-07-28" version="1">MSDPISQFEFPKIYSFPPFYTQQPNTTVLNQQLDSWVSIILHYCEYYRITSLSIEGIPKHSQLEVPLSSLSSIFINKTINRQVNSDFQKLIVKHLIHNKKAEFINPKKPELGVYIYWRSLVDWGDLLYQYVEDTGQKGTVLTIYELTKSEETTVPQDLHNLDETFLVKIIKDYLIKQGKAQLLIDENNEIGGVKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS16</accession>
    <name>C4YS16_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_04874</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Caudal homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS16"/>
    <dbReference type="PaxDb" id="5476-C4YS16"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04874"/>
    <dbReference type="HOGENOM" id="CLU_028430_0_0_1"/>
    <dbReference type="OMA" id="RIKTGFH"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009948">
        <property type="term" value="P:anterior/posterior axis specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000519">
        <property type="entry name" value="Homeobox transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047152">
        <property type="entry name" value="Caudal_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24332">
        <property type="entry name" value="HOMEOBOX PROTEIN CDX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24332:SF9">
        <property type="entry name" value="HOMEOTIC PROTEIN CAUDAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="34"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="36"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="355"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="428"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="658"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="377"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="484"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ46519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="685" mass="76337" checksum="979775622A3F43A1" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS29</accession>
    <name>C4YS29_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_04887</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EEQ46532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YS29"/>
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    <dbReference type="HOGENOM" id="CLU_011607_0_1_1"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
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        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="348"/>
        </location>
    </feature>
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        <location>
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            <end position="476"/>
        </location>
    </feature>
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        <location>
            <begin position="51"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ46532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="482" mass="55815" checksum="F1C9272FD7C5A101" modified="2009-07-28" version="1">MLKLKSTHFLSLILLVIWVLTFYLQERYLTAATISKCQWPQLSTSSSQTNILLIADPQLIDNHTYPGRNELLLKLSKHTVDTYIKKNYNELLDQLQPNYIMFLGDLLDNGRDATDEYFAQEYNRFKRIFRPSDKMFLNVPGNHDIGFGNGVKIPMRTRFEKSFGSANTVVDIDGVDFIILDTLSISSTDETINKQSKDFLYSIAKEKSKPRILLTHVPLYRDPNLSCGPLRESKTFDVNGYGYQYKNSVEESLSRDILNQIQPDITFTGDDHDYCDIQHENGYREVTVKSISMAMGKKYPAVQLLSIKNEDNFKMETEICFLQTPYINVANYVVLAIVSGILIFWWNLKTKLTRYTYTSILPLHDVVNIPFEHTKKLHRFIKEQDDEHMEQKHLDISLPTSSSSNAYSLPSSIPQYTFTQSSRPQFVTKFNNTRLGKIYILNKRRLFTFIKRYSLVSFFKQSLMVGISVASIYYVGFVLTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSA1</accession>
    <name>C4YSA1_CANAW</name>
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        <submittedName>
            <fullName evidence="13">AdoMet-dependent rRNA methyltransferase SPB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_04963</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="PaxDb" id="5476-C4YSA1"/>
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    <dbReference type="OMA" id="QRKDKYY"/>
    <dbReference type="OrthoDB" id="1287559at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
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        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="27"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3381" evidence="12">
        <location>
            <begin position="246"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase SPB1-like C-terminal" evidence="11">
        <location>
            <begin position="621"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="461"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="587"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="496"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="513"/>
            <end position="527"/>
        </location>
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        </location>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
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    <sequence length="737" mass="84483" checksum="F9EB2FB99B525A22" modified="2009-07-28" version="1"> </sequence>
</entry>
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    <accession>C4YSC1</accession>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
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</entry>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Lin M.F."/>
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                <person name="Forche A."/>
                <person name="Reedy J.L."/>
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                <person name="Brunke S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="EMBL" id="EEQ46655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSR7</accession>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Grabherr M."/>
                <person name="Forche A."/>
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                <person name="Logue M.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    <sequence length="550" mass="60109" checksum="4C7577BE5F143234" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
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                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
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                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000001429"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSU3</accession>
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        </recommendedName>
    </protein>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
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    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
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                <person name="Staggs R."/>
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                <person name="Berriman M."/>
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                <person name="Lorenz M.C."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="15 16">WO-1</strain>
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        </cofactor>
    </comment>
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        </subcellularLocation>
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        <property type="evidence" value="ECO:0007669"/>
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    <dbReference type="PANTHER" id="PTHR12849">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
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    </dbReference>
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    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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        </location>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01124"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="464" mass="54120" checksum="2BBA76A53EF55CAF" modified="2009-07-28" version="1">MSNTLKIAIEGCCHGELNDIYNSIPDIESLDLLLICGDFQSLRNKCDLQSLNVPLKYQRMADFHEYYSGKRKAPVLTIFIGGNHECSSYLQELKYGGWVAPNIYYLGEFGSIWYKGLQITGWSGIFNYHTFIANNIEMEKLPFDSRTIRSVYHQKLANFLKMYMMNHDMDIVLSHDWPVGIEKYGNSKRLLKLKPFFRDDIQRGQLGSPLNKFLIHYLRPRYWFSGHLHVKFEARIVDLVRSTDKKKSATTTDSITESNKEEISLDMDDEEEEEGGNVREVSFEEKFYFKQHSNPAKRPKNDLTPERDVCEHATEFLALDKCGKRRQFLDIKTIEVHNTSHPSFINAGKLYYSKRSIAINKVVEKYLNDNRQDFTELNTKQILSNPQQFPLVNELMPIIENDFKSMQKNITDEDFFMVPENFQTIAPTDDEHTESKLKYYPNNQTSEYCEKFGIPKLVLSKESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSV2</accession>
    <name>C4YSV2_CANAW</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05171</name>
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        <name type="scientific">Candida albicans (strain WO-1)</name>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
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                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
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                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">WO-1</strain>
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            <dbReference type="EMBL" id="EEQ46805.1"/>
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    <sequence length="561" mass="64238" checksum="056A9B6A2790033B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Candida albicans (strain WO-1)</name>
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    </organism>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
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                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
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                <person name="Klis F.M."/>
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                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
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                <person name="Quail M.A."/>
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                <person name="Santos M.C."/>
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                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
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            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="L domain-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="581" mass="67451" checksum="54412D006973BF76" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTB1</accession>
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            <fullName evidence="8 19">3-isopropylmalate dehydrogenase</fullName>
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        </recommendedName>
    </protein>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 19">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="19">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="19">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 19">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 19">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="7 19"/>
    <dbReference type="EMBL" id="CM000313">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="PaxDb" id="5476-C4YTB1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05397"/>
    <dbReference type="HOGENOM" id="CLU_031953_0_3_1"/>
    <dbReference type="OMA" id="EYDLGAR"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF1">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="16 19" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9 19" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="11 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 19" id="KW-0520">NAD</keyword>
    <keyword evidence="13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="20">
        <location>
            <begin position="7"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00019276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EEQ46852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="373" mass="40056" checksum="313E80C2CC9BCD48" modified="2009-07-28" version="1">MSVKTKTITVLPGDHVGTEIVNEAIKVLKAIEAATPYQKIQFDFKHHLIGGAAIDATGVPLPDDALESAKSSDAVLLGAVGGPKWGTGTVRPEQGLLKIRKELNLYANIRPCNFASDSLLELSPLKAEVVKGTNLIIVRELVGGIYFGERQEQEESEDKKTAWDTEKYTVDEVTRITRMAAFMALQHNPPLPIWSLDKANVLASSRLWRKTVDKVISEEFPALSVQHQLIDSAAMILIQNPTKLNGIIITSNMFGDIISDEASVIPGSLGLLPSASLASLPDTNTAFGLYEPCHGSAPDLPANKVNPIATILSAASMLRLSLDCVKEAEALEEAVKQVLDSGIRTADLRGTSSTTEVGDAIAETVTKILKQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTT2</accession>
    <name>C4YTT2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTT2"/>
    <dbReference type="PaxDb" id="5476-C4YTT2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05577"/>
    <dbReference type="HOGENOM" id="CLU_083354_1_0_1"/>
    <dbReference type="OMA" id="AYFNVID"/>
    <dbReference type="OrthoDB" id="4018368at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946897" evidence="1">
        <location>
            <begin position="20"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="152" mass="16502" checksum="E571B41CDAC75B25" modified="2010-10-05" version="1">MRFFTAATTALLFSAQALAGITQYTLSIEADDERVNGKGITFKHEGAGINYAFVSDSSAKFNYDDESKLFYYPISPQLNYNLGTAGDIVQFSVTPPSSVEIGDDGALKFEGSDELFAAVSINDPYHYSDKDFAVIVKGKNHAIPIKLVAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTW4</accession>
    <name>C4YTW4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTW4"/>
    <dbReference type="PaxDb" id="5476-C4YTW4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05610"/>
    <dbReference type="HOGENOM" id="CLU_166515_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="141" mass="16886" checksum="F666471B5C11D291" modified="2010-10-05" version="1">MNQSNNESNTERRNSIEEEDALHYHYHEYSVSQVQHEKNKQEISMVEIERLKKANSEYRDSIDKIKEILIVNDQKIDSQKEAFSSLMKSALKQVDKNYQLKIEMNKLRKELVDAQARLVEFKDEWCIFGPELKKIRRQKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTZ9</accession>
    <name>C4YTZ9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_05647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ47090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTZ9"/>
    <dbReference type="PaxDb" id="5476-C4YTZ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05647"/>
    <dbReference type="HOGENOM" id="CLU_016174_1_1_1"/>
    <dbReference type="OMA" id="RHENIYG"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF64">
        <property type="entry name" value="OS12G0206100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ47090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="723" mass="82007" checksum="6809BA4710DD02B4" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCV1</accession>
    <name>C4YCV1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_00335</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YCV1"/>
    <dbReference type="PaxDb" id="5476-C4YCV1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00335"/>
    <dbReference type="HOGENOM" id="CLU_029633_0_0_1"/>
    <dbReference type="OMA" id="QDYLSPM"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11387">
        <property type="entry name" value="bHLHzip_USF_MITF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000105">
        <property type="entry name" value="Rtg3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051732">
        <property type="entry name" value="USF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117:SF3">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="351"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="45"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ42137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="520" mass="57248" checksum="1815A59E0961CEF6" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YCZ2</accession>
    <name>C4YCZ2_CANAW</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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        <lineage>
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            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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            <taxon>Candida</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="PaxDb" id="5476-C4YCZ2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00379"/>
    <dbReference type="HOGENOM" id="CLU_028609_0_0_1"/>
    <dbReference type="OMA" id="RPINHET"/>
    <dbReference type="OrthoDB" id="6375767at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
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        <location>
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            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="520" mass="58888" checksum="2573658CF4462BFF" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDB3</accession>
    <name>C4YDB3_CANAW</name>
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        <recommendedName>
            <fullName evidence="7">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">CAWG_00503</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
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                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
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                <person name="Heitman J."/>
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                <person name="Lorenz M.C."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PP2C family.</text>
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    <dbReference type="HOGENOM" id="CLU_013173_1_1_1"/>
    <dbReference type="OMA" id="MCEESDG"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein phosphatase type 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
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        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="81"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ42299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="375" mass="40744" checksum="7E18E5DE69B253C1" modified="2009-07-28" version="1">MASTDTDNSKTVSSSTSSPSTPTKTATTKTTATPPIQSSLEVPSLANNSNGSSSTSTSSTNASSTGANDSNYDPFAGLSFRVGVAENKNTTFRNKMEDVHTYIANFAERVDWGYFAIFDGHAGKDTARWCGNNLHTLLEEEIDRNSDEGSPPPTPIRGKDDLREDLYKCFVKADELIEKSGQGKSGCTAAVAVLRWESDNEEPVSHTKSQDGGKFDFKPTKNHKRLLYTSNVGDSRIVLCRAGQAYRLSYDHKATDTHEINRIEDNGGLVLKNRVNGVLAVTRSLGDTYMKSLVIGVPFTTATEITADDEFIIIACDGLWDVVSDKHACKLAAESFKQGYSPSQVAKKLCQFAIELSTTDNVTVMVVQLDNDVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDD3</accession>
    <name>C4YDD3_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome c oxidase polypeptide Vb, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_00526</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase IV family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDD3"/>
    <dbReference type="SMR" id="C4YDD3"/>
    <dbReference type="PaxDb" id="5476-C4YDD3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00526"/>
    <dbReference type="HOGENOM" id="CLU_070101_2_0_1"/>
    <dbReference type="OMA" id="YVIHLFA"/>
    <dbReference type="OrthoDB" id="186013at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00922">
        <property type="entry name" value="Cyt_c_Oxidase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.442.10:FF:000002">
        <property type="entry name" value="Cytochrome c oxidase subunit V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.442.10">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004203">
        <property type="entry name" value="Cyt_c_oxidase_su4_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036639">
        <property type="entry name" value="Cyt_c_oxidase_su4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707:SF10">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02936">
        <property type="entry name" value="COX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81406">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ42319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="165" mass="18637" checksum="971D440E382857FD" modified="2010-10-05" version="1">MFMRSLQRAATKANTASITTSILRFNSTVAKSTSAAPRALSNAYIGNLESRWTSLPKQDQQTLIDELKSRMELPWQELTPAEKKAAYYISFGEWGPRTPLYLPGERSQVFWITTGCIVASVVLFFGIRQFASPPPITMNKEWQEQSDDYLKSKNANPFTGYSQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDD5</accession>
    <name>C4YDD5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytosolic Fe-S cluster assembly factor NAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cytosolic Fe-S cluster assembly factor nar1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nuclear architecture-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_00528</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDD5"/>
    <dbReference type="PaxDb" id="5476-C4YDD5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00528"/>
    <dbReference type="HOGENOM" id="CLU_018240_0_1_1"/>
    <dbReference type="OMA" id="GYLHHVL"/>
    <dbReference type="OrthoDB" id="10253113at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase large subunit C-terminal" evidence="7">
        <location>
            <begin position="119"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ42321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="605" mass="66903" checksum="82263AD488CD57DF" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDI7</accession>
    <name>C4YDI7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDI7"/>
    <dbReference type="PaxDb" id="5476-C4YDI7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00582"/>
    <dbReference type="HOGENOM" id="CLU_1959283_0_0_1"/>
    <dbReference type="OMA" id="QANEMKD"/>
    <dbReference type="OrthoDB" id="4010410at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="123" mass="13966" checksum="7647277AC1C8B66D" modified="2009-07-28" version="1">MVSISENFTNSFPRNITALNSQKRGMPLQETSPNIINKSPIKQQPGSVISSKKRLAGSPVSLQRESVRLKVNKPESTPTDFDSTFGTTEAEIELNYRNWLLERRLQQANEMKDFLILEQEVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDL0</accession>
    <name>C4YDL0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chromatin structure-remodeling complex subunit SFH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_00607</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YDL0"/>
    <dbReference type="SMR" id="C4YDL0"/>
    <dbReference type="PaxDb" id="5476-C4YDL0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00607"/>
    <dbReference type="HOGENOM" id="CLU_014421_4_0_1"/>
    <dbReference type="OMA" id="MWNLNES"/>
    <dbReference type="OrthoDB" id="10258327at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ42396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="40605" checksum="B7209BC4D953C761" modified="2009-07-28" version="1">MATSQELTADIQALATSFPKRLANDSDNSLLINVAPTGRQAKRHIQQINYSEEFGDDLDFDEFPSSTPGTRSLNENKAQIEAQRYSLAKNTPTPKRILEKPVLSELVEKPVVLIPIKIMIENLNTNQKLIDSFMWNLNESLITPTEFAEIVCSDLDLPFSMAAQIADSINQQIEEYSYASNLQLPNKGPYNVTIDLSVNLNKQLYQDRFEWDMNQNEVTPEIFAEIVVADLGLSLEFKNAISHALHEIIIRVKKEVIDGTFNNEMHNLHLVKGIMFEQGIRIFTENSVQNGNDRWEPLVEVLTSSEIERRENERVRNLRRLKRENMRRDYDDHSRRRQAGKRRYDELEGAWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>C4YDX9</accession>
    <name>C4YDX9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein ZIP4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_00727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00727"/>
    <dbReference type="HOGENOM" id="CLU_013693_0_0_1"/>
    <dbReference type="OrthoDB" id="65716at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090173">
        <property type="term" value="P:regulation of synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Spo22/ZIP4"/>
    </dbReference>
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        <property type="entry name" value="Spo22/ZIP4/TEX11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375:SF2">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08631">
        <property type="entry name" value="SPO22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00031845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ42515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="701" mass="80782" checksum="481EFFBA9105BD73" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>C4YE39</accession>
    <name>C4YE39_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_00792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YE39"/>
    <dbReference type="PaxDb" id="5476-C4YE39"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00792"/>
    <dbReference type="HOGENOM" id="CLU_074386_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ42575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27848" checksum="421BEC1FC788ECBF" modified="2009-07-28" version="1" fragment="single">MTILSTDVDLFSEVAKLPSEVITIIVDHLPKCILPELLHFPPIRREIASTILSDVYITENVQRHKGSDELLVGHSSCDCNHFKIKLIKLKQGITQWNIYPKTIHLERIEQFTNVSNNFPELLTEALSINGIFFGKEVLESNELTKFLENSNIKFDMIILNDFQDLVKIPPVATTISLFDTLLDNYNIPDVKKIDIEMKSRSMDSEFYDFPIDMDELQIKGEMLFQATLIPNLRKLCITAEYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YE93</accession>
    <name>C4YE93_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YE93"/>
    <dbReference type="PaxDb" id="5476-C4YE93"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00847"/>
    <dbReference type="HOGENOM" id="CLU_052376_0_0_1"/>
    <dbReference type="OMA" id="SLIMCGG"/>
    <dbReference type="OrthoDB" id="4078735at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ42629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="338" mass="38822" checksum="B2DBE1B54E674E27" modified="2009-07-28" version="1">MSINPNLKLFKLINNRKNNNNSTDTMNSQQQQKSQQQSQQQHQHQQKNKYNSFDATSSILSDYDDLEVIDDDQSSYVLFNPKSLASSSRGKQKSQHHDSDILSFTNTSNTNDEYQSDTEKEEEDSEIEEEEEEDEAQEDDRVSLDNENNDTEVLNRDRLSHKINSWYTANVVSSSHHQSLIDERIASWELDEEANILESSQESSKSLEESKSILREFYGDDLFKYLNQDEIAKVKKFHKMVDIKNYLLDKTNKNNNSLLDQLLYKVLLFKEKKHNDTTFHRQYNIGTTDYINYLTKDVPSYIPAFVAPSTISDTTTGGSSLIMCGGVGFGGSASWNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEE4</accession>
    <name>C4YEE4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_00901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEE4"/>
    <dbReference type="PaxDb" id="5476-C4YEE4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00901"/>
    <dbReference type="HOGENOM" id="CLU_408316_0_0_1"/>
    <dbReference type="OMA" id="IIWNVRE"/>
    <dbReference type="OrthoDB" id="2095648at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052301">
        <property type="entry name" value="SCF_F-box/WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14381">
        <property type="entry name" value="DACTYLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14381:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="37"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ42680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="661" mass="76765" checksum="675A486DC06E6D81" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEJ7</accession>
    <name>C4YEJ7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_00954</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEJ7"/>
    <dbReference type="MEROPS" id="M01.006"/>
    <dbReference type="PaxDb" id="5476-C4YEJ7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00954"/>
    <dbReference type="HOGENOM" id="CLU_003705_0_1_1"/>
    <dbReference type="OMA" id="MMEYVAI"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000004">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="108"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="321"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="612"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ42733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="954" mass="107306" checksum="B40DF4E64E174DF2" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEM8</accession>
    <name>C4YEM8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_00985</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEM8"/>
    <dbReference type="PaxDb" id="5476-C4YEM8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00985"/>
    <dbReference type="HOGENOM" id="CLU_072097_0_0_1"/>
    <dbReference type="OMA" id="WQFDVEI"/>
    <dbReference type="OrthoDB" id="1806at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF11">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="7">
        <location>
            <begin position="14"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ42764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="211" mass="24238" checksum="A4ADB86FE0E50E65" modified="2009-07-28" version="1">MPSSLELSSKLALKGSSKIVCDYFEFALNSILYQRGIYPQEDFVTVKKYDLPMVINDDYDVQKYINNIMKQIKKWIYGSLMSKFIIVIVSKTNLENIERWEFNIETKDQEETTENGDGDGVGKSRQEIQKEIRAIIRQITSSVSYLPVLKDDEYTFNVLVYTDPNTSVPIEWCDTQGDGKVLDGDNVDNVKFTSFSTDIHQVGTSVSYKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C4YEW3</accession>
    <name>C4YEW3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_01072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YEW3"/>
    <dbReference type="PaxDb" id="5476-C4YEW3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01072"/>
    <dbReference type="HOGENOM" id="CLU_052194_0_0_1"/>
    <dbReference type="OMA" id="DSENWID"/>
    <dbReference type="OrthoDB" id="5551751at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040200">
        <property type="entry name" value="Mug57-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156:SF1">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946575" description="FAS1 domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ42849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="46460" checksum="8709AEBE9BB78E33" modified="2009-07-28" version="1">MKLSKLLQLAVFSSLVTSKNIFDLESLKQGLQNEETVTNDKREPVNLLYLDRFKMGVSDEEKGNAKSKRDPKNVIDSASLKEGSAEEEQKDKREPKNLFNLQALHESLKDEETKSKREAKNLPNLEALEEALKGGSLPKKDAKNLIDLVALKQSLEKEAAKRDAKNIPDLEALKTGIEEEEGQVAKRDAKNVINLSNFIETPSKRESKNLFDLTKFQQSGQPIKKRDQKILTQEKSLFVLNSVDCFNNLLQSILPQLSSISIFSSYIRQFASIDARTANPQKVMLIVAPDNDSLETKLSDLKPWEFPEQITPEQSEQEQDKTLKNNLLHFLNGHLINNFEENLVIDKSSTDAVTIISKLNNGKFLKIKQDQLSQKFSIRLLDSENWIDVETIKQVENGFVLIINDSLVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YF78</accession>
    <name>C4YF78_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_01190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_012487_1_0_1"/>
    <dbReference type="OMA" id="MFLKPYR"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="eIF2D_C"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="eukaryotic translation initiation factor 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EIF2D"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PUA_eIF2d-like"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR057429">
        <property type="entry name" value="WH_eIF2D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
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    </dbReference>
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        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ42964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="505" mass="56717" checksum="7184121DF2B10BCE" modified="2009-07-28" version="1">MFKKPAQIKPSSNIKTSERKRLLSCIADAYSLPLEELTKEETEKILPSTIKKASFVSFEKVSGSIYFDENEVPVWFHTRDSDIYPTIFTLMKYPTILPTIATHPHVLGVLAKGADLMLPGTVPPFDKRAVKGAIVGIVSHDNPQKVTAIGHCKLNMTQFDSVVGRSGVAVEIIHHLDDTLLEKKELTIPVSDTVKEQSNETVPEPKPAKEQKHELPELTTEEIDNLFIKSIKSVNNIELPTPASTFMSYVNKNVPSSITMKKTSWKKASKFLKEMAKLNYIKVKGKDEELSIIQLNITTSESNATPKTKSKPTSTSNASPNTLKVIPLYKPTKNLRLFFNKLDAEYDEYFTAAAAKSLLESYIKKFSLVADDPKLIKPDAELGTKTEMPRDQLLKHFLTKFSPYYQINNSVVYKGTPPKIEIVTELKIGRKVVTRVSNYEKFEIKTETLAKELRNKCSGSSTIVDNDVQVQGPHGKLIIDILKEKGVPVSYINFEDKTKKKKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFD0</accession>
    <name>C4YFD0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Maintenance of telomere capping protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_01247</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFD0"/>
    <dbReference type="PaxDb" id="5476-C4YFD0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01247"/>
    <dbReference type="HOGENOM" id="CLU_024520_0_0_1"/>
    <dbReference type="OMA" id="RTSHWDE"/>
    <dbReference type="OrthoDB" id="4064064at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038769">
        <property type="entry name" value="MTC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38426">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38426:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="723"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ43016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="757" mass="86913" checksum="7729FDF62A8FF64A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YFG6</accession>
    <name>C4YFG6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_01284</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
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                <person name="Shah P."/>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="662"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="690"/>
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        </location>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
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        <source>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
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                <person name="Kodira C."/>
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                <person name="Martin R."/>
                <person name="Neiman A.M."/>
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                <person name="Skrzypek M.S."/>
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                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ43124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YFX3"/>
    <dbReference type="PaxDb" id="5476-C4YFX3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01361"/>
    <dbReference type="HOGENOM" id="CLU_2372561_0_0_1"/>
    <dbReference type="OMA" id="YIRVIYY"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="115" mass="13207" checksum="0A68DF509F2C7A72" modified="2009-07-28" version="1">MGYIRVIYYTGPLFVFIYSTYSFCIVTCNLINKNVVTMPRRGVLTVSYTKSNKAVTAQDLTFTSGITRVFCKSFKSIKRLKTFCLRIWSKFPPKNNHLRIVVVESTDSSKERSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG08</accession>
    <name>C4YG08_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sporulation-specific protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_00121</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YG08"/>
    <dbReference type="PaxDb" id="5476-C4YG08"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00121"/>
    <dbReference type="HOGENOM" id="CLU_035846_2_0_1"/>
    <dbReference type="OMA" id="NNNRYME"/>
    <dbReference type="OrthoDB" id="536881at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051648">
        <property type="entry name" value="CWI-Assembly_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018:SF3">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="340"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="355"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ41932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="47361" checksum="5D4D0D2904BD83C8" modified="2010-10-05" version="1">MDLEMDIPFHCRKNEFLIHNQFDLQNISNCEVIIGNIIISEFDYPIITFSNLEKLLGNLTILKSPDTVRIDAPIMELISGTFKMIELTSLALISFPALKWVNTLHWKILPILSNVHFNNEIKGIDNIIISDTSLTGFSGFLAESIENLDINNNRFLDTIESNVETISGELHIGANSNDVKVSFPKLKQIGLLNINDVEKLNLPELEFIDDSLILNNNNFQQLKFSKLNYIGGTLSLFENLGVNDLEFPNLNELGGGLVMINNSLIERINFFPKLKIIGGALELIGNIKEISLKNLKLVKGSAIVKSTSSIFDCKKWSKTEIMLVVRGGRIECTDSNNEKITSRTKEDGTGGELITTPTTTTTTKTNSKSTYSGGRSGGNDDVKMNKETTSSSSGCCGGNVFVNGLQHFTLFQFIAILITLVNSFVLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG74</accession>
    <name>C4YG74_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonucleases P/MRP subunit Pop8-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_00193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ41998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YG74"/>
    <dbReference type="PaxDb" id="5476-C4YG74"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00193"/>
    <dbReference type="HOGENOM" id="CLU_2621785_0_0_1"/>
    <dbReference type="OrthoDB" id="4077720at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020347">
        <property type="entry name" value="Pop8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049128">
        <property type="entry name" value="Pop8-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28173">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28173:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20976">
        <property type="entry name" value="Pop8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonucleases P/MRP subunit Pop8-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ41998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="78" mass="9035" checksum="B34EBD1B8698BFFD" modified="2009-07-28" version="1">MKSMNKLYGLIGESIPFEILSQSTDEKNSIIIKIYKQDFERFSNGLFSFTFSLMDYYGIDINCYIKIEKSGQFLGLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YG97</accession>
    <name>C4YG97_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alanyl-transfer RNA synthetases family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_00218</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YG97"/>
    <dbReference type="PaxDb" id="5476-C4YG97"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00218"/>
    <dbReference type="HOGENOM" id="CLU_004485_7_1_1"/>
    <dbReference type="OMA" id="CMHTSQH"/>
    <dbReference type="OrthoDB" id="288942at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002196">
        <property type="term" value="F:Ser-tRNA(Ala) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000023">
        <property type="entry name" value="Alanyl-tRNA synthetase-related protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000012">
        <property type="entry name" value="Threonyl/alanyl tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051335">
        <property type="entry name" value="Alanyl-tRNA_Editing_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462:SF1">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN AARSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="316"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ42021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="471" mass="52260" checksum="95B210EF4A240237" modified="2009-07-28" version="1">MATSATGTTTAIVGALACQKNSFLKTFNTKVVSSYEFIPPPTAKDKQNKNNNNKKKDVAVSKEFGVELEDTILFPEGGGQPYDKGTITLLPDNTKIIEVKSVLRDKLKAIHLVDELIEPGTQVRLNVDWGRRLDIMQQHTGQHLLSAVFDTYKLETLSWSMGETKDDINYIELPRKIDNDLVVEVQNKVNQLIVDSIPITVVTSDQHGHGQEHEHEHEHEHEHADIDISHIPDDYDLSQGGIIRIVKIGELDANPCCGTHLTSTAQIQSIALLHQSPIRGGHSRLHFICGGRVANHLRKEHEILKNVSTNQLSCSIDAVEEKIELLSLNYKKTNSTLNNLLKELASIEANKIFQNFKTHDNNNSKLAYVYRADLPEYLTSVQKELTTLINQDKTGDVDISNKQTLVLLSGAAPNGGTIKILGPKAEELQKELKSKLSNLKGGGKGSSFQGKITKFEKGELEAVLKYLDSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGA0</accession>
    <name>C4YGA0_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Multifunctional tryptophan biosynthesis protein</fullName>
            <ecNumber evidence="6">4.1.1.48</ecNumber>
            <ecNumber evidence="5">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_00221</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two components I and two components II.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="6"/>
    <dbReference type="EC" id="4.1.3.27" evidence="5"/>
    <dbReference type="EMBL" id="CH672346">
        <property type="protein sequence ID" value="EEQ42024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGA0"/>
    <dbReference type="MEROPS" id="C26.959"/>
    <dbReference type="PaxDb" id="5476-C4YGA0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_00221"/>
    <dbReference type="HOGENOM" id="CLU_039523_0_0_1"/>
    <dbReference type="OMA" id="EPIEWAN"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000031">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF4">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="15">
        <location>
            <begin position="12"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="16">
        <location>
            <begin position="231"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ42024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="520" mass="58280" checksum="0A1225DCF9EA27AD" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGF3</accession>
    <name>C4YGF3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_03129</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGF3"/>
    <dbReference type="PaxDb" id="5476-C4YGF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03129"/>
    <dbReference type="HOGENOM" id="CLU_008074_2_0_1"/>
    <dbReference type="OMA" id="MLNGVPC"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009644">
        <property type="entry name" value="FKTN/MNN4/W02B3.4-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407">
        <property type="entry name" value="FUKUTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407:SF28">
        <property type="entry name" value="RIBITOL-5-PHOSPHATE TRANSFERASE FKTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="6">
        <location>
            <begin position="382"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ44835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="692" mass="80879" checksum="8A89DFDD93A9C5BB" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGK3</accession>
    <name>C4YGK3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_03182</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGK3"/>
    <dbReference type="SMR" id="C4YGK3"/>
    <dbReference type="PaxDb" id="5476-C4YGK3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03182"/>
    <dbReference type="HOGENOM" id="CLU_071116_2_1_1"/>
    <dbReference type="OMA" id="LPTHMKF"/>
    <dbReference type="OrthoDB" id="49520at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029525">
        <property type="entry name" value="INO80C/Ies6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="6">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ44885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="137" mass="15821" checksum="80D713CC23748C8B" modified="2009-07-28" version="1">MSSTPITTTTTTQVNLHELSEITTKPHSFKQNPNRKQQSNRRYKPSRQLISDELKYLQSKQSNLKFDTPTYNSIMSPPSLKPTMKYCDITGLPTNYKCPSNQLRFYNSEIYQEVIKNMPAGVDQEYLQLRGANVILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YGS5</accession>
    <name>C4YGS5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein FAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ44957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YGS5"/>
    <dbReference type="PaxDb" id="5476-C4YGS5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03257"/>
    <dbReference type="HOGENOM" id="CLU_069402_0_0_1"/>
    <dbReference type="OMA" id="FEAQFKP"/>
    <dbReference type="OrthoDB" id="5556956at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053030">
        <property type="entry name" value="Ribosomal_biogenesis_FAF1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096:SF1">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="37097" checksum="2AC4CD2E5BE0E138" modified="2009-07-28" version="1">MSEDDEYIKALEIQRRNFEAQFGSIEDMGFEDKSKTQVELEDEDERSSQDSPDQSSGEDEEDSEFDEIDSDSNEEEMDFLGDDEEQDDIPKPKVFKLNDSSNTPLPVVSKQDRKLLKSGRAPTLLEISKKEKLAAKQQSKQQSAKSKAEDEENLANDLKLQRLLKESHILANTLEYSGADLTLQTIDFDDPTGKARRRALDSRIRELASTNSRTGGLPKKLEKMPMAMRKGMIKKRDERIKKYEQDARDAGIVLSKVRKGELRDLDAGRGSTSSSDRLGTGKKIDKRIRDRGLKINGIGRSTRNGLVISQGEIDRVNRGGKKGFRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH65</accession>
    <name>C4YH65_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acyl-coenzyme A diphosphatase SCS3</fullName>
            <ecNumber evidence="8">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">FIT family protein SCS3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SCS3</name>
        <name evidence="8" type="synonym">FIT2B</name>
        <name evidence="10" type="ORF">CAWG_03406</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization. Involved in phospholipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65568"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:156554"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(9Z)-octadecenoyl-CoA + H2O = S-(9Z-octadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:156553"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an acyl-CoA + H2O = an acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132023"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>hexadecanoyl-CoA + H2O = S-hexadecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50032"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132018"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the FIT family. Fungal FIT2B/SCS3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YH65"/>
    <dbReference type="PaxDb" id="5476-C4YH65"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03406"/>
    <dbReference type="HOGENOM" id="CLU_048143_2_1_1"/>
    <dbReference type="OMA" id="FTSWFFG"/>
    <dbReference type="OrthoDB" id="5579088at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03231">
        <property type="entry name" value="SCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019388">
        <property type="entry name" value="FIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046400">
        <property type="entry name" value="SCS3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10261">
        <property type="entry name" value="FIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ45097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="316" mass="36660" checksum="FA084AC84B4A8E1E" modified="2009-07-28" version="1">MNKLFKSIHTQTKLNIYEFLFAISFLVNFILGRFIHFSAPDEEVYNYYNNKRNILNQWFVKKGWGWTTLVIILFYSNIIYKQYNSKATTNTTTTNNNNNNKQGVIVQTIRNAVINYIVVTIWWIFFTQWCFGLPIMDKIFVLTGGKCSIDTNSMAHFNPNHHHVHANFVQKLENIWESTGITSYNCRRIEGSQWIGGHDPSGHVFLMIHSSLYLFNEMINYWPGWTYIKHNLSQILTSGNDNGNGNGNGTRSLSIGDKLLLLWNTPQLIIGGLIGLWWFMLLMTNIYFHSSLEKMVGLGFGYIGVAGLYWIPRWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YH96</accession>
    <name>C4YH96_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_03441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YH96"/>
    <dbReference type="PaxDb" id="5476-C4YH96"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03441"/>
    <dbReference type="HOGENOM" id="CLU_010119_6_2_1"/>
    <dbReference type="OMA" id="GDQMELW"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000051">
        <property type="entry name" value="Clavaminate synthase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="172"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ45128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="336" mass="38188" checksum="D316CE8F6DB93D55" modified="2009-07-28" version="1">MSNPLKVIDISEDSITTARELLDAATSQGFLFLEGHDFTQEEVDKLFELSKSFFELPNNYKSKYPVDSSNHGYVMMGKENLDPNGQKQGDPKEALNIANLNFETGKSLNIIPDWISENQKRDELISNTILRLYRLSIKILRMLARALEIEDDETHRIKGENWFASKYASDSESGSTFRLLHYPCQKSLNPESVIRAGAHTDYGSMTLLFQKENQEGLEIFSPISKKWEQVPFIPSTIEKMAPPLVVNIGDLLSYWTAGLLKSTIHRVKFPAKAQELGQDRYSIVFFSHPSDNALLEPVPSEIIRKIEGRGANKETTYITAKQHLQKRLAATYGWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YHD9</accession>
    <name>C4YHD9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Splicing factor 3B subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_03485</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
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            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03485"/>
    <dbReference type="HOGENOM" id="CLU_002242_0_1_1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="870"/>
            <end position="941"/>
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    </evidence>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ45171.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="1094" mass="125018" checksum="0CB343D7FD8B0702" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YI38</accession>
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        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
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                <person name="Hube B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Forche A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672349">
        <property type="protein sequence ID" value="EEQ45455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YI73"/>
    <dbReference type="SMR" id="C4YI73"/>
    <dbReference type="PaxDb" id="5476-C4YI73"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03782"/>
    <dbReference type="HOGENOM" id="CLU_051277_0_0_1"/>
    <dbReference type="OMA" id="MTYGYMI"/>
    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000003">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000005">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ45455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="348" mass="40190" checksum="A3CC847D58DE4EC3" modified="2010-10-05" version="1">MEGLFFNIDYGYLEGVVRGYKSGLLTSNQYVNLTQCDNLEDLKLQLSSTDYGNFLANYSGPLSTTVIQENLTKKLFQQYQYIQSQSSGKLTKFMDFINYGYMIDNVILMITGTLHERDKSEILRKTNALGWFDTLPTLSIATDIESLYSTVLIDTPLAPFFKNCVSADDLDDLNIEIIRNRLYKNYLEGFVDWCDKNLDGPDKEIMERLLTLEADKRVINIALNSLNNPDLSPEDKLSLFPSHGKLYPTYHLELSQVDDVEQLKSIVELVGDYKDIFSETNENLKSLGDWFYYLEMQLCRNAFTQQFTLASVYAWLKSKEQEIRNITWIAECIAQNQKNRIESYIAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIA1</accession>
    <name>C4YIA1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_04173</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TACO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIA1"/>
    <dbReference type="PaxDb" id="5476-C4YIA1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04173"/>
    <dbReference type="HOGENOM" id="CLU_062974_1_0_1"/>
    <dbReference type="OMA" id="FGPGGCM"/>
    <dbReference type="OrthoDB" id="2017544at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.980:FF:000002">
        <property type="entry name" value="Probable transcriptional regulatory protein YebC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048300">
        <property type="entry name" value="TACO1_YebC-like_2nd/3rd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049083">
        <property type="entry name" value="TACO1_YebC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532:SF0">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20772">
        <property type="entry name" value="TACO1_YebC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="YebC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TACO1/YebC-like N-terminal" evidence="7">
        <location>
            <begin position="29"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="TACO1/YebC-like second and third" evidence="6">
        <location>
            <begin position="106"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ45836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="285" mass="32002" checksum="993FAAA67FD020A8" modified="2009-07-28" version="1">MIKSLITRNSTRIRGANTNLTLVRFAGHSKWQNIRHDKAKNDARKSKEATLISGRIESCVRVGGKESNARLEQLLEKAKALNVSKAVVEKAIKRGCGELTDTAQLQNVQYEFMGPGGVAIIVNALTDNKARTVSMVKNAMTYFQATLSPCSYMFDKMGEVIFLPKDNDESFDDVFEVALEIGAEDVEEFEFDDEFVPGKVHKFYRLLCAPTSINQVSNDLSAKGYKLHESTVRFLANSDSQVPFPEDQSKGYLRALDNLDQINDVTDYYTNIEEEHKERIVSSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIE4</accession>
    <name>C4YIE4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_04217</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIE4"/>
    <dbReference type="PaxDb" id="5476-C4YIE4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04217"/>
    <dbReference type="HOGENOM" id="CLU_004447_2_0_1"/>
    <dbReference type="OMA" id="FYRYWSA"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
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        <property type="entry name" value="BRAHMA ASSOCIATED PROTEIN 155 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Myb_DNA-binding"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
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            <begin position="426"/>
            <end position="523"/>
        </location>
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            <begin position="631"/>
            <end position="682"/>
        </location>
    </feature>
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            <begin position="634"/>
            <end position="686"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="577"/>
            <end position="641"/>
        </location>
    </feature>
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        </location>
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            <begin position="37"/>
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        </location>
    </feature>
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            <begin position="92"/>
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        </location>
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            <begin position="919"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ45879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="979" mass="110181" checksum="C73E5062F0847D73" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIG8</accession>
    <name>C4YIG8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor IIIA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_04242</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14 15">WO-1</strain>
        </source>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Putative zinc finger protein 143"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
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        <property type="entry name" value="C2H2-ZF_domain-containing"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC FINGER PROTEIN 200"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="6"/>
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        <property type="entry name" value="ZnF_C2H2"/>
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    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
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    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
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            <end position="54"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
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            <end position="199"/>
        </location>
    </feature>
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        <location>
            <begin position="351"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
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            <begin position="288"/>
            <end position="324"/>
        </location>
    </feature>
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        <location>
            <begin position="9"/>
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        </location>
    </feature>
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            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ45903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="418" mass="48231" checksum="206B028C3D354A66" modified="2009-07-28" version="1">MSESDETKSISSLISSSSSSRPKKYICTYEGCDKAYNRPSLLEQHLRTHSNDRPYKCTVEDCDKAFFRKSHLETHIVSHSEKKPFHCSVCGKGVNSRQHLKRHEITHTKSFKCTFENCQEAFYKHQSLRHHILSVHEKTLTCKQCNKVFTRPSKLAQHKLKHHGGSPAYQCDHPGCFKNFQTWSVLQFHIKQSHPKLKCPKCGKGCVGKKGLSSHMLSHDDSTMIKIWTCDYCDVGKFAKKNELVEHYNIFHDGNIPDDLLKETEVKKLENLLDQGSKLNSLHELETEKLKVKEDEEEDDDDEEEEDSLDEKRSDVRSDSMSAQRSIKSFTASLEGSKSVSKLISNSGKKINCPKNNCDRMFSREYDLRRHLKWHDDNLQRIESFLNSIEKEETPEGEPLVKKARMDLLPNETSVISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIQ1</accession>
    <name>C4YIQ1_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
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                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EEQ45986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04327"/>
    <dbReference type="HOGENOM" id="CLU_023466_0_0_1"/>
    <dbReference type="OMA" id="SESIPQH"/>
    <dbReference type="OrthoDB" id="4095763at2759"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021216">
        <property type="entry name" value="DUF2722"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10846">
        <property type="entry name" value="DUF2722"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
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        </location>
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        </location>
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            <end position="544"/>
        </location>
    </feature>
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    </feature>
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            <end position="438"/>
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    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EEQ45986.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
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    </evidence>
    <sequence length="544" mass="59209" checksum="8AA33D2F09B692D6" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIR7</accession>
    <name>C4YIR7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Las1p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
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                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
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                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
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                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002:SF0">
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    </feature>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="56655" checksum="3B2862D1C32BD830" modified="2009-07-28" version="1">MKQHPLVTAYKGIDDLQQLKKWFYEYNDTIDHRKKAISKVKGLLTRGKLPHGVEATSLLTSIVLDDLQRKDIDSCVLQLSYTMALIRFVNGLLDPYQQSNYAIPMHLLAKQLNLPTYFVELRHMGTHENLPSLDILRSTCSKALTWLYDNYWCHVEEANQDKQVSIGGALTDAVEFRSNDLRTRIEDSQIYNNLKAFKRIRKQDLNKVYEKNDTTSDLAATYHRCVSDIVEFAKENCDLLVNVLLLKNYLIYPSSKIKDKKSKFNPLIIKLYEPLFEALGLSFKLKCFSKTIELIEATPSSFVDKKVYRKLGFTEKFEYDELFQVMEWVLYFMQDLLRKENVPSPVRNKNELVILFLDSLKSIEQKIPQSLLPSFAKILQGLCDVVNDGVKSEIDPETVQKLDAWNKSLNNLHSTKKFFELPPSLDDLLGLSPSPGPIPETTSSNPMKHVLDDDDEEEEGVRRKQHHSSDSETYILKPHKNWRPIPFGTCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIV7</accession>
    <name>C4YIV7_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sphingoid long-chain base transporter RSB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_04386</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
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                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
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                <person name="Sherlock G."/>
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                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
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                <person name="Berriman M."/>
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                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
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            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ATP-dependent translocation of sphingoid long-chain bases (LCBs) from the cytoplasmic site toward the extracytoplasmic side of the membrane (flip-flop). Involved in the establishment of the functional lipid asymmetry of the plasma membrane. Regulates intracellular levels of LCBs, sphingolipid precursors that are growth inhibitory at increased levels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lipid-translocating exporter (LTE) (TC 9.A.26.1) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="258"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="424"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ46042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="464" mass="52185" checksum="8993C8553F284D95" modified="2009-07-28" version="1">MNTMDLAAITEWTPTSTATSTTLSTIAATYAPALQSKISGAVHTLTSKGSTIANMDYISASRIIRGAQASLSIISAEHVLETATATDVQAQATQIIWQATENLLDLAWEENVYDIPRLNRTANILFLVLFAITFAIACLMWIKSRYWWFNVAWTCGTALEFLGYLGRVLSFSDMKKFDYYLLQLIALTLSPVFLMAGIYFLFGQLVVIHGRQYSWLKPLHYSYIFITCDVVSLVIQAVGGGMTAIAAQEYDDVDPGTYTMIAGIAFQVFSMSVFLLCWLVFCWNIYFRDISVNESKPSPYQKKSLMTFIKLLLNGDDANMYKLKVLDKYYNSSYKDLRRRPLYNYYAIAITLAVIAVYIRCIYRVVELAQGFSGYLITHEVYIMTLDAAMIGICCIIFILFHPQVVMGSSNVVGLRSIAKNKDQETGDNSYEEKTNNDIVSDNEESTLQGQNIVRGDPIQENKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>C4YIX2</accession>
    <name>C4YIX2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CAWG_04401</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ46057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YIX2"/>
    <dbReference type="PaxDb" id="5476-C4YIX2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04401"/>
    <dbReference type="HOGENOM" id="CLU_000288_67_4_1"/>
    <dbReference type="OMA" id="TVCNDRI"/>
    <dbReference type="OrthoDB" id="18472at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000141">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000319">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000109">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF417">
        <property type="entry name" value="CELL CYCLE PROTEIN KINASE DBF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="24"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="341"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ46057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="492" mass="56853" checksum="7EB12775CBA78891" modified="2009-07-28" version="1">MEKLYWDSRALLRKRRLKPKHKDFEMITQIGQGGYGQVFLSRKRDTREICALKILNKKLLIKLDETRHVLTERDILTNTRSDWLVKLLYAFQDQEKVFLAMEFVPGGDFRTLLNNTGYLIPPHARFYISEMFAAVNSLHELGFTHRDLKPENFLIDSKGHIKLTDFGLAAGTVCNDRIESMKIKLQNLQNLNDFNDDSNNDNHHYQVPSSLIYERQKIFKQSQQQQQNSNNTTANSIVGSPDYMALEVLEGKNYNYTIDYWSLGCMLFEALCGYPPFSGSKQDETYYNLKHWKTALRRPQTKDGRYVFSDRTWNLIIKLIASPNNRLQNFKQVQQQSYFSDIKDWGNLRQKTPPFTPQLDNEEDAGYFDDFEDDEMMMKYKDVFARQEQNEQLLEKSNTTTTTTTTTTTKNGKRFSPGSKFNDNFIGFTFKHKSNPNNKFTNGSGNTGRYGNGNGNNNNNGEINLLNMVENGNGIGNGNSRSSRLNPLATLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ28</accession>
    <name>C4YJ28_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Scaffold protein Nfu/NifU N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_03840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ28"/>
    <dbReference type="PaxDb" id="5476-C4YJ28"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03840"/>
    <dbReference type="HOGENOM" id="CLU_060555_0_2_1"/>
    <dbReference type="OMA" id="AIMEHYM"/>
    <dbReference type="OrthoDB" id="565552at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000004">
        <property type="entry name" value="HIRA-interacting protein 5, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035433">
        <property type="entry name" value="NFU1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
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        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036773">
        <property type="entry name" value="HIRIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="2">
        <location>
            <begin position="18"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ45512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="237" mass="26924" checksum="EC2328008DD28512" modified="2009-07-28" version="1">MFVNKRLLAYIPKRLYHFKTLPTPNPNALKFISPECNILPMNDKTFEFTTTLQAIHSPLALTLFKIPGVKSVMLGHDFLTVNKQDYINWANLRPGIVEQLDEFLTSKKHPVITKELVDEAQREAEEESELISMIKELIETRIRPAIQDDGGDIELKGFDEETGTVFVKLQGACKSCSASEDTLKHGIESMLMHYVEEVKEVIQILDPEEEIAVKEFERLEQKLKNGNSQGEQAPPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ31</accession>
    <name>C4YJ31_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ER transporter 6TM N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_03843</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ31"/>
    <dbReference type="PaxDb" id="5476-C4YJ31"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03843"/>
    <dbReference type="HOGENOM" id="CLU_012000_0_0_1"/>
    <dbReference type="OMA" id="GTYHWFI"/>
    <dbReference type="OrthoDB" id="2274698at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF1">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="671"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="696"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="721"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="751"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="782"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="815"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="4">
        <location>
            <begin position="85"/>
            <end position="558"/>
        </location>
    </feature>
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        <location>
            <begin position="836"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ45515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1107" mass="125769" checksum="3FF1B68D7BEA0194" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJ47</accession>
    <name>C4YJ47_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_03859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJ47"/>
    <dbReference type="PaxDb" id="5476-C4YJ47"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03859"/>
    <dbReference type="HOGENOM" id="CLU_562557_0_0_1"/>
    <dbReference type="OMA" id="DWIFESG"/>
    <dbReference type="OrthoDB" id="4012433at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005668205" evidence="1">
        <location>
            <begin position="21"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ45531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="485" mass="54925" checksum="298585BC5F8A8B3C" modified="2009-07-28" version="1">MHFTSSLLATLIWFTLPVQSLNTESRTTSNNTISILTNNFQILKDLLPYSKTSKPQIKESRPLIKVSRDGVPINFHRAPAIIMKSNKTDNLVRNSNKTMVLTEIKTITEFATTTVSPTQEFQALQINLNTLSIETSTPTFQSHDFPPITIEDTPKTLEPEESSDALQRDAFDQIKKLEKLVLDLRLEMKEQQKSFNDQLVDIYTARSIVPIYTTHIVTSAIPSYVPKEEVMVSHDSAPIVSRPRTDIPVSQRIDTISKHKMNGKNILNNNPPPNSVLIVPQFQFHERMATKTEVAYMKPKIVWTNFPTTTATSMFDNFILKNLVDETDSEIDSGETELSDDYYYYYSYEDDGKEDDSDEITAQILLSNSELGTKTPNFEDPFEQINIEDNKVISVNTPKTKKPTTTVFGTSTSALSTFESTIFEIPKFFYGSRRKQPSSFKNKNSTIKFDVFDWIFESGTTNEKVHGLVLVSSGVLLGTCLLFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJN9</accession>
    <name>C4YJN9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_04057</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672350">
        <property type="protein sequence ID" value="EEQ45723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YJN9"/>
    <dbReference type="PaxDb" id="5476-C4YJN9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04057"/>
    <dbReference type="HOGENOM" id="CLU_007860_1_0_1"/>
    <dbReference type="OMA" id="RSRQTCF"/>
    <dbReference type="OrthoDB" id="2427554at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
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        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF2">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="4">
        <location>
            <begin position="78"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="672"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="580"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="680"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ45723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="718" mass="82216" checksum="2B929B92E18981E9" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YJU8</accession>
    <name>C4YJU8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ada DNA repair metal-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CAWG_04118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">WO-1</strain>
        </source>
    </reference>
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    <dbReference type="HOGENOM" id="CLU_027889_1_0_1"/>
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    <dbReference type="OrthoDB" id="2447880at2759"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="9"/>
            <end position="73"/>
        </location>
    </feature>
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        <location>
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            <end position="212"/>
        </location>
    </feature>
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            <begin position="272"/>
            <end position="306"/>
        </location>
    </feature>
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            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ45782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="547" mass="60333" checksum="73697AB2E257E892" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>C4YK66</accession>
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        <recommendedName>
            <fullName evidence="9">Sister chromatid cohesion protein PDS5</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">CAWG_05862</name>
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    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
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        <lineage>
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            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
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            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05862"/>
    <dbReference type="HOGENOM" id="CLU_002562_1_0_1"/>
    <dbReference type="OMA" id="YPPAYNM"/>
    <dbReference type="OrthoDB" id="200660at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19953">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001362">
        <property type="entry name" value="Sister chromatid cohesion protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF0">
        <property type="entry name" value="PRECOCIOUS DISSOCIATION OF SISTERS 5, ISOFORM A"/>
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    </dbReference>
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        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1227"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1288"/>
            <end position="1302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ47295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1302" mass="148531" checksum="53D88F7CE9D62EB0" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKA6</accession>
    <name>C4YKA6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Repressor of RNA polymerase III transcription MAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05903</name>
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    <organism evidence="3 4">
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
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            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKA6"/>
    <dbReference type="PaxDb" id="5476-C4YKA6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05903"/>
    <dbReference type="HOGENOM" id="CLU_037043_2_1_1"/>
    <dbReference type="OMA" id="INIGPFG"/>
    <dbReference type="OrthoDB" id="277029at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1000.50:FF:000014">
        <property type="entry name" value="Repressor of RNA polymerase III transcription MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037240">
        <property type="entry name" value="RNA_polIII_Trep_MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ47335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="383" mass="43191" checksum="906A5C46489C8ECA" modified="2009-07-28" version="1">MKYIDEVDLELVNQELNFHSPDNNLVIKGGCELFTTKPIGSDRKLFKTIDKHLDQIIEDNQFSRSIEREKRNSISSMFGSNASSPDLRRHSAISISDMRRRASSNSGSINFNRNSLPKNEQHNDNNNNNNTSLLSQSLNDSGVIDDNEHAIDESPFGPLKNVTTRKTFAYLIAILNSSFPDQDFTNLQPTTENFYRIESPDELVHRFNNVLLSLGKKEDILNWIWDIINSYMDVLPSKNSSPYIAAQNSGGSRHGSFSASTGNSSPPSNSSYETCQIYQFQPSDESILEDLTYPYQPMWSYYYFIYNKKKKRVTFIHIAAINKADYSNGNGNQGSGNSENSSNRAKVINSDGEEEYDVNDDYGAVVDDDDDDENEDVVGGLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKE0</accession>
    <name>C4YKE0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_05942</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKE0"/>
    <dbReference type="PaxDb" id="5476-C4YKE0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05942"/>
    <dbReference type="HOGENOM" id="CLU_652104_0_0_1"/>
    <dbReference type="OMA" id="NKCSEST"/>
    <dbReference type="OrthoDB" id="4096612at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025928">
        <property type="entry name" value="Flocculin_t3_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13928">
        <property type="entry name" value="Flocculin_t3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ47369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="414" mass="45116" checksum="A9C59323A9F97417" modified="2009-07-28" version="1">MVFPFFTFHSRDDYNVQFYYAIINSHRYTTDIKHGGSIISIAAKLLYDKHTPIYQVHLHKIPNSNSTEIIRKRWLFAKNKQIKSSSSSKILSKKDLVDDFIIDIAGSRGIMIDKVILSVVDVDQMTSSIATGSSNSLTRTGFTNPSMISTKTSNSQSITTTTTKGSSATTTTTATATGATETITTTKIITITSCSNDICHLTTVPASLTTVTTTGTVYTTYLPINSVETVVSTKIITITSCSNNNNNNNNNHVCHPTTVLATPSTMTKTIDNTITEYITYCPLTQQPEQVSTINPYTGASATSVTATITSCWEETCQTYITTTAAATAVIITQTEITTVETVTHDTTTYYVTYTITSQTSNQVHTTKINNEGGNTNELSSSLPAITTTVEGRGISNKIENLLSMLIMVMVMWFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKK5</accession>
    <name>C4YKK5_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_06011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKK5"/>
    <dbReference type="PaxDb" id="5476-C4YKK5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06011"/>
    <dbReference type="HOGENOM" id="CLU_1740256_0_0_1"/>
    <dbReference type="OMA" id="DFFMENE"/>
    <dbReference type="OrthoDB" id="4007415at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ47434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="150" mass="17185" checksum="7E4C318ADF5B3D67" modified="2009-07-28" version="1">MQVINDTSLLSEKYLTVVSYDDMTSPNYMAKLSKLSNSLHKQGLDLHKVCLIMRFKIKLKTSLQIAGVNYQVYSTISKLNRLISSLYEGLDLDCESSTDIKFNDFGDFGDSTKRCISIENFDFFMENEFLVGLENDSDPDTRLVYDNFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YKY2</accession>
    <name>C4YKY2_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor SLT11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_06141</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLT11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CH672354">
        <property type="protein sequence ID" value="EEQ47561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YKY2"/>
    <dbReference type="PaxDb" id="5476-C4YKY2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_06141"/>
    <dbReference type="HOGENOM" id="CLU_027112_1_1_1"/>
    <dbReference type="OMA" id="RNVCQCC"/>
    <dbReference type="OrthoDB" id="10259600at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12265">
        <property type="entry name" value="RRM_SLT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034356">
        <property type="entry name" value="Slt11_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="STL11/RBM22-like N-terminal" evidence="10">
        <location>
            <begin position="7"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ47561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="303" mass="33848" checksum="9303AD1C71C6B804" modified="2009-07-28" version="1">MSTDIFSICAKCLGDESRIKMIKQVNGDECRQCTRPYTIYRWGNRKQGNKTIICITCARARHCCQSCLLDITYGIPTDLRDTALEMAGLEPLTKSANPTNREVKAIMADKLETKFKEQQERSNDILSKLAEKLNKPEEKKTEVAIDVAKLAKKLPFGNSLDVQKYPDMTTFFVFGFSSDFPQAIFSRYAEQYGKVESVVFSSASGCGFIRFEKVSSAVGFAKSIAENGLNKNKSIAGLLILENTPMRVCFGKQKPLPRTAADQRKLNTVVTKVMKQLASKSKVGVVVKTKPNVYKALSEDYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLD1</accession>
    <name>C4YLD1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein sorting-associated protein 55</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CAWG_01649</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLD1"/>
    <dbReference type="PaxDb" id="5476-C4YLD1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01649"/>
    <dbReference type="HOGENOM" id="CLU_134810_0_0_1"/>
    <dbReference type="OMA" id="ICARCAN"/>
    <dbReference type="OrthoDB" id="14246at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034424">
        <property type="term" value="C:Vps55/Vps68 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF0">
        <property type="entry name" value="RH04491P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ43412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16264" checksum="E22ED57EBC1E9743" modified="2009-07-28" version="1">MNPLNKIIFLSAFLASGFLLILLSCALYNNYHTLWVILIFLLAPLPNLIANSIESARDYNFLTFNDYGNSNDSTQSPLQEFGKYITGFLTVSGIALPLTFYHCGLIELGATIMSIIGGLIVYSDIIIFIWFFNTEEEEHDDFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLH4</accession>
    <name>C4YLH4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_01692</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLH4"/>
    <dbReference type="SMR" id="C4YLH4"/>
    <dbReference type="PaxDb" id="5476-C4YLH4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01692"/>
    <dbReference type="HOGENOM" id="CLU_023312_0_1_1"/>
    <dbReference type="OMA" id="FAWQGMQ"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14518">
        <property type="entry name" value="DSP_fungal_YVH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000116">
        <property type="entry name" value="YVH1p Protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016278">
        <property type="entry name" value="DUSP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000941">
        <property type="entry name" value="DUSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="59"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="5">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000941-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="322" mass="37008" checksum="A115907F2EFF7F19" modified="2009-07-28" version="1">MSVKRILGGLYLSSIDPIFKEIDLKSEYGITHILSVVPGTMKESYFSDYEWKQIEITDEETTNVIQYFPESYAFIESALFQNSNDKKHQSCVLVHCSQGVSRSATFIIAYLMQKYHLSIDQALHAVKRKCPGAEPNPGFMNQLKLYNEMGFKIDESNQKYNEILKSNSLKTDPTGRSLRDMIMEKSGSPKEVKEESLYELRCKRCRQILASSVHIENHDIPESDSRQSSFIKTAPNSRRIISVERASSVCSHYFFKEPVKWMKQELDKAEMEGKFQCPKCSSKVGGYSWRGSRCSCGKWMVPAIHLQEAKVDYIKRESTLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLH9</accession>
    <name>C4YLH9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_01697</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLH9"/>
    <dbReference type="PaxDb" id="5476-C4YLH9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01697"/>
    <dbReference type="HOGENOM" id="CLU_009308_2_0_1"/>
    <dbReference type="OMA" id="SFKFWVH"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.30:FF:000004">
        <property type="entry name" value="Vacuolar transporter chaperone, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF2">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 3 COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="694"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="735"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="558"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="584"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ43460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="784" mass="91530" checksum="884BB80CF5240F84" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLP7</accession>
    <name>C4YLP7_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional activator hap3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_01766</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLP7"/>
    <dbReference type="SMR" id="C4YLP7"/>
    <dbReference type="PaxDb" id="5476-C4YLP7"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01766"/>
    <dbReference type="HOGENOM" id="CLU_066247_12_3_1"/>
    <dbReference type="OMA" id="NEDMPVW"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22907">
        <property type="entry name" value="HFD_NFYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000179">
        <property type="entry name" value="Transcriptional activator hap3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003956">
        <property type="entry name" value="Transcrpt_fac_NFYB/HAP3_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00615">
        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00685">
        <property type="entry name" value="NFYB_HAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="5">
        <location>
            <begin position="16"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ43528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="105" mass="12286" checksum="20CB6165DA191BA8" modified="2010-10-05" version="1">MNQQNARDIELREQDRWLPIANVARIMKNTLPPTAKVSKDAKECMQECVSEFISFITSEASDKCLKEKRKTINGEDILYSMYDLGFENYAEVLKIYLAKYREARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YLQ8</accession>
    <name>C4YLQ8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Temperature shock-inducible protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_01777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YLQ8"/>
    <dbReference type="SMR" id="C4YLQ8"/>
    <dbReference type="PaxDb" id="5476-C4YLQ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01777"/>
    <dbReference type="HOGENOM" id="CLU_129392_0_0_1"/>
    <dbReference type="OMA" id="ATELPWY"/>
    <dbReference type="OrthoDB" id="4069694at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000992">
        <property type="entry name" value="SRP1_TIP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00660">
        <property type="entry name" value="SRP1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002946612" description="Temperature shock-inducible protein 1" evidence="2">
        <location>
            <begin position="23"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ43539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="16830" checksum="8C8A673C49957E75" modified="2010-10-05" version="1">MRFAFTTVSLSLLLSSLVASDAASSDVQFLTALVGDYQDHKTDYIKFFATAKDVPGDLSTLATKVLTYTDDSYTTLLNDDSLNVSNLEAYATSLPWYSRIQADAGGKGSASGSASGSGSAKSTASAEKSSGSSASASSTAGGSSSKGGVSELVAPVGAVVGALAVALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM11</accession>
    <name>C4YM11_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Transcription factor IIIB 70 kDa subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">B-related factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_01886</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">General activator of RNA polymerase III transcription. Interacts with TBP. Binds to Pol III subunit C34 and to the TAU135 component of TFIIIC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM11"/>
    <dbReference type="SMR" id="C4YM11"/>
    <dbReference type="PaxDb" id="5476-C4YM11"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01886"/>
    <dbReference type="HOGENOM" id="CLU_010293_3_3_1"/>
    <dbReference type="OMA" id="EPPCKVM"/>
    <dbReference type="OrthoDB" id="511529at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20553">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20554">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000012">
        <property type="entry name" value="Putative transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000002">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000007">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.650:FF:000004">
        <property type="entry name" value="Transcription factor TFIIIB subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.650">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="16">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="473"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ43642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="553" mass="61840" checksum="FEC1E270B15EEEC1" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM14</accession>
    <name>C4YM14_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM14"/>
    <dbReference type="PaxDb" id="5476-C4YM14"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01889"/>
    <dbReference type="HOGENOM" id="CLU_1916781_0_0_1"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="132" mass="15339" checksum="22DBC81535FEFFCD" modified="2009-07-28" version="1">MKGDKKKFSPLFFFSYCQFLVVRVAFFFLVPHFSITRSFLLSPLPLFSSLPSSSPPPKSLSNKFFFSFLQNSDHSLCPPASPRFSHQILFFQQTFLLSPLFSSAHFYYHNYNQSFGTRTHPIHPQSFDTTHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YM42</accession>
    <name>C4YM42_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_01917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YM42"/>
    <dbReference type="PaxDb" id="5476-C4YM42"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01917"/>
    <dbReference type="HOGENOM" id="CLU_737691_0_0_1"/>
    <dbReference type="OMA" id="EVKINYL"/>
    <dbReference type="OrthoDB" id="4026095at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="375" mass="41589" checksum="9AAFB9FA10F183E7" modified="2009-07-28" version="1">MTDNVENKDSMITAYTRISPDSSDSRFIKIVKFQHHADKTLTSIPFPSPLPNNTSASNHINLKTSDDKTVQLGKKIMQRLYNVGVLSRDVIQKCRESSSTVFSSESSVVASSSSSTQNNSILPNSNNGSENGDDHSLLSSPTSPTSTSSGMSTSNSILSKTSETSSSPPGNGKKKRGRKRKLSSDDKQIQIDNYKIYNCKIKLNMTHNDEKFDVRLQFVYKTKPKVTTTHHHNHSKNNSKDSNYINSGNHARNGSQNHNGNGVSSRDTNSSFSSNNNTSPNGLAKLLNPSPTTETSNLRNGKTNHSMATTGSIIPLEEEEAPNMYITYDELINYLRDKIFFTENKKNLHGIEVKINYLLHLCTFKCSINETEIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMC8</accession>
    <name>C4YMC8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="3">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_02007</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="3"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YMC8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02007"/>
    <dbReference type="HOGENOM" id="CLU_000893_1_0_1"/>
    <dbReference type="OMA" id="MKANFFV"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05167">
        <property type="entry name" value="PI4Kc_III_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000011">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000022">
        <property type="entry name" value="Phosphatidylinositol 4-kinase stt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000014">
        <property type="entry name" value="Phosphatidylinositol 4-kinase STT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045495">
        <property type="entry name" value="PI4K_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF15">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19274">
        <property type="entry name" value="PI4K_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="9">
        <location>
            <begin position="1376"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="1627"/>
            <end position="1910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ43759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1926" mass="218933" checksum="6130D0FFF3490369" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMC9</accession>
    <name>C4YMC9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_02008</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMC9"/>
    <dbReference type="PaxDb" id="5476-C4YMC9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02008"/>
    <dbReference type="HOGENOM" id="CLU_010226_0_1_1"/>
    <dbReference type="OMA" id="FQAQAFI"/>
    <dbReference type="OrthoDB" id="5212126at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF2">
        <property type="entry name" value="FLAVIN CARRIER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002944815" description="ML-like domain-containing protein" evidence="9">
        <location>
            <begin position="23"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="599"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="25"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="646"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="680"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="781"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="724"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="735"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="787"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ43760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="810" mass="89597" checksum="AD5C54F26A857A63" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMH8</accession>
    <name>C4YMH8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VPS4-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_02060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMH8"/>
    <dbReference type="PaxDb" id="5476-C4YMH8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02060"/>
    <dbReference type="HOGENOM" id="CLU_088285_2_1_1"/>
    <dbReference type="OMA" id="FYVCPAH"/>
    <dbReference type="OrthoDB" id="2158714at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013640">
        <property type="entry name" value="Vfa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218:SF1">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08432">
        <property type="entry name" value="Vfa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ43809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="22987" checksum="144106232C9C2001" modified="2009-07-28" version="1">MSKPPQQPPFPNKYHVKLVASPDSKACLICYKPATTVLLADGNGDFFYTCPQHLLDDQFANAIHPQEYTELLDKKQTLTDKKSKLEKDVESEKPYIWNTVAGYWKSKDKDKDKGKDKDKYTESKYEKLKQELVDVTKELEETSKKISEFKFKLYQLNQDIYKNRLMSYQKKKYSQQRAVKIQEEGFFPSVPKHSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMK6</accession>
    <name>C4YMK6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phenol 2-monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_02088</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMK6"/>
    <dbReference type="PaxDb" id="5476-C4YMK6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02088"/>
    <dbReference type="HOGENOM" id="CLU_009665_9_2_1"/>
    <dbReference type="OMA" id="DKSKMGP"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF20">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="7"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="320"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="7">
        <location>
            <begin position="477"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ43837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="709" mass="80024" checksum="FA05C24D8CCB5431" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YML3</accession>
    <name>C4YML3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carnosine N-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_02096</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnosine N-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YML3"/>
    <dbReference type="PaxDb" id="5476-C4YML3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02096"/>
    <dbReference type="HOGENOM" id="CLU_030612_1_2_1"/>
    <dbReference type="OMA" id="EFWVAKK"/>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030735">
        <property type="term" value="F:carnosine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF6">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ43844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="395" mass="45381" checksum="A888B0F8E1FC0AFB" modified="2009-07-28" version="1">MSQNADEYEALTATLSSFYNFFRHQFEHIIKPRLIKFRAMTEKERALLPWYEAHTGELKQCIEVNRGFTELLSTSIANDWGVAGTSLDWHPAGPREFEITSTTLLQLMREWSDEGQAERDVAFTRIISELEELYPDEPSRQSIRILNPGCGLGRLVMELVIRGFWTQGNEISYHMLLASNFILNHSQFPHSHSIFPFLSRSSHLVKRKYQTRGITIPDVAPFAVLSELKEKTPSIAYEELMPITAGSFLELYGPNKPSDTLNDPAAIELKNSSKDSFDVVVTNFFLDTASNIIEYVRAINHVLKNGGRWINFGPLLWHFEGDYNVSYINREDNVSIPDIKKGLELSREDLLELIKNMGFDFVKHESDIESTYCKDIKSLGSFVFKCEYWVCIKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMM6</accession>
    <name>C4YMM6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_02109</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMM6"/>
    <dbReference type="PaxDb" id="5476-C4YMM6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02109"/>
    <dbReference type="HOGENOM" id="CLU_029501_2_0_1"/>
    <dbReference type="OMA" id="VHEVYQQ"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106335">
        <property type="term" value="F:tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000219">
        <property type="entry name" value="tRNA (Carboxymethyluridine(34)-5-O)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051422">
        <property type="entry name" value="AlkB_tRNA_MeTrf/Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069:SF21">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="60"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ43857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="265" mass="30138" checksum="0B059FEBED4A8341" modified="2009-07-28" version="1">MATPVPSVSVESGLDPQNQEVTYVHEVYNEIASHFSQTRYKPWPIVEKFLMSRSKHSVGLDVGCGNGKYLNVNKDVFIIGTDRSEGLIKCAQQISENKYNLGVADGLALPHPDGTFDFAISIAVIHHFATEERRIEAVQHILSKLREGGEALIYCWALEQETSRRGYKEGDDQDVLIPWVLKKQQPSKKKGANKRKQKSESVSEQPESTEQPADAEETEPDVTKYRYYHLYKKGELVDNCLQTKCCTIVEEGYEKDNWWVIIKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMP3</accession>
    <name>C4YMP3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS13m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_02127</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMP3"/>
    <dbReference type="PaxDb" id="5476-C4YMP3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02127"/>
    <dbReference type="HOGENOM" id="CLU_103849_2_4_1"/>
    <dbReference type="OMA" id="IYPNCRM"/>
    <dbReference type="OrthoDB" id="525520at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000001">
        <property type="entry name" value="30S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.910.10:FF:000004">
        <property type="entry name" value="Small subunit ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ43874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="122" mass="13808" checksum="1E691864FBCEDA9D" modified="2009-07-28" version="1">MGVVVFGKSIKHNFPVRIGLAKTIFGIGYQTAERLMAKVGIYPNCRMNQLTEPQIMDLNKEISQLLVEGHLKHKIINDIKMKRTIGSYAGSRHALGFPVRGQRTKTNGSTARQLNRTERFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMT3</accession>
    <name>C4YMT3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acyl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_02170</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMT3"/>
    <dbReference type="PaxDb" id="5476-C4YMT3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02170"/>
    <dbReference type="HOGENOM" id="CLU_018204_1_2_1"/>
    <dbReference type="OMA" id="WNMFLSK"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF13">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="10">
        <location>
            <begin position="56"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="9">
        <location>
            <begin position="146"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="8">
        <location>
            <begin position="269"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ43914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="49377" checksum="3C193BCB46E925A9" modified="2009-07-28" version="1">MSVKEDIPAVFLEKVSPRGLEAIQKTKDFVNDYCLPADQIYFEQLSDIPSERWKSVPPVIETLKKKAKELGLWNMFLSKHYKEGPQYTNLEYGLMARYLGRSYTAPEATNTAAPDTGNMELFAKYGTTYQKDRYLKPLLNGEIRSAFLMTEKGVSSSNALNISTSAVKNSNGNYVLNGVKWFASGAGDPRCSVWLVMCKTDNNKQNPYQNHTVLIIDAKKALATGKVKLIRPLQVIGFDDAPHGHCEIQFQDYEVPADEMPNVVMAGVGRGFELIQSRLGPGRIHHCMRAIGAGEFALLRIAHRANHRLIFGKPMNQREGFLSRYGQSKIDIERCLLLVLNAAHKIDISNAKEAQKEIAMAKIETPRTISDILDWGIQVYGAEGMSQDTELARMYAHNRTLRIADGPDEAHLAQLARNEAKKFAKVDDFFANMETQRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YMV3</accession>
    <name>C4YMV3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sulfite efflux pump SSU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_02190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YMV3"/>
    <dbReference type="PaxDb" id="5476-C4YMV3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02190"/>
    <dbReference type="HOGENOM" id="CLU_030057_6_2_1"/>
    <dbReference type="OMA" id="LGPNWYA"/>
    <dbReference type="OrthoDB" id="1099at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000319">
        <property type="term" value="F:sulfite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09318">
        <property type="entry name" value="TDT_SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.150:FF:000004">
        <property type="entry name" value="Malic acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051629">
        <property type="entry name" value="Sulfite_efflux_TDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686:SF1">
        <property type="entry name" value="SULFITE EFFLUX PUMP SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ43934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="54218" checksum="5FFE55A5ADF5816B" modified="2009-07-28" version="1">MSSSSHNDNKIPPEKTTTPPLSSSNEDIYNPADSSNVLSSNQTLVSTNNNNNNQNNNQNNNQNNDGKDTMDHLSYLSTIDSKRREQSYLKSFYQRFIIEDVVKNFTPAYFVSVMGTGISSSLLYNFPFPAYWLQICGYVMFGLTCTFFIGNIILLIMSCAYYPNRFRDYHVDPSRAVFMGAFSMGYITIVNFIALITKGEHIYFVWTLWWLAVFSAMYTSFLIVYLSFMSKLNESDVEAKLNATLLLPIVAITVVSSSGHSIELDLPHVHQTVLTMIVSFMLWSLSISMAFMVMTLYMWRLIIHKIPPTNLIMTSFLPVGFLGQSSYSIYLFGNNLNKFIPEELLYGKISLCLSGFVSVFLLSFGYFMCFVAVTSVLSKIRPFAKNPNPSHTNRFGLLKLEKSFWSMTFPMGTMSLSNTEIGHGGVGNYPLLTFKVMGSIFAAACIFITVGCSIGVVVYSFKKLREDMTNKNKYRNESMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>C4YN15</accession>
    <name>C4YN15_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase epsilon subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA polymerase II subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_02254</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase epsilon subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000309">
        <property type="protein sequence ID" value="EEQ43996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YN15"/>
    <dbReference type="PaxDb" id="5476-C4YN15"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02254"/>
    <dbReference type="HOGENOM" id="CLU_010628_1_0_1"/>
    <dbReference type="OMA" id="PEDGAWF"/>
    <dbReference type="OrthoDB" id="10254730at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="9">
        <location>
            <begin position="398"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ43996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="708" mass="81096" checksum="5AEECA7D9205204A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNK0</accession>
    <name>C4YNK0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CAWG_01462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="EEQ43233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNK0"/>
    <dbReference type="PaxDb" id="5476-C4YNK0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_01462"/>
    <dbReference type="HOGENOM" id="CLU_020419_0_0_1"/>
    <dbReference type="OMA" id="DMHRLQN"/>
    <dbReference type="OrthoDB" id="4096032at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome R"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ43233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="848" mass="97918" checksum="D113FFF490ED5A3F" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNQ0</accession>
    <name>C4YNQ0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S19-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_02832</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
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                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="SMR" id="C4YNQ0"/>
    <dbReference type="PaxDb" id="5476-C4YNQ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02832"/>
    <dbReference type="HOGENOM" id="CLU_108559_3_0_1"/>
    <dbReference type="OMA" id="WAPFVKT"/>
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    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000118">
        <property type="entry name" value="40S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
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    </dbReference>
    <dbReference type="SMART" id="SM01413">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ44559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="145" mass="16072" checksum="BC1C458A43EFB30F" modified="2009-07-28" version="1">MPGVSVRDVPAQDFINAYAQFLQRQGKLEVPGYVDIVKTSAGNDLPPQEAETWFYKRAASIARHIYLRKQVGVGALNKLYGGAKNRGFRPHKHVDASGSINRKCVQALQKIGVLEISPKGGRRISENGQRDLDRIAAQTLEEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YNZ0</accession>
    <name>C4YNZ0_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <name type="common">Yeast</name>
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        <lineage>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
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                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YNZ0"/>
    <dbReference type="PaxDb" id="5476-C4YNZ0"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02923"/>
    <dbReference type="HOGENOM" id="CLU_686952_0_0_1"/>
    <dbReference type="OMA" id="TESKYEY"/>
    <dbReference type="OrthoDB" id="4014270at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="401" mass="46992" checksum="4D1FD05BADA3F283" modified="2010-10-05" version="1">MTSTKSSPLSILYQKFPFDQCLDDHLFDTTNLIKHGLNLTIQMGTLTLNDIPSSEENIQTVDKLPQVLSDNQTQMSETNDEEIDYHIPPSPILIPIEPPKSSIKRRNSSNSSIGSFTTTTSSSPITENSTTRSSSSSDMSLLICRKKLQNMIEEFFITICNQNEKLYQEISNYVINSIVQNESNLESFLSKIVNHKYKRELVEIIQTLFMEKYEEIKLEELIDFLNNLINLRLDAIKDLYNPSVYKMYYKIWKLNINNYRYYDEEYFFDYFNNSFSNSENVLLQNGFLLNYKKFTHYFSKDLTNYDDDEEEDEEQDNDEEELDANDKIKDDSLCHNDTAPSSPNYAYKCEDTDNQQLSLDPLDQDHIPKSLRFNEDIDIININRYLPVDHVLYNQFLNQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPD3</accession>
    <name>C4YPD3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fcf2 pre-rRNA processing C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_03086</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPD3"/>
    <dbReference type="PaxDb" id="5476-C4YPD3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_03086"/>
    <dbReference type="HOGENOM" id="CLU_075129_2_0_1"/>
    <dbReference type="OMA" id="RWFNMKQ"/>
    <dbReference type="OrthoDB" id="427886at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039883">
        <property type="entry name" value="Fcf2/DNTTIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014810">
        <property type="entry name" value="Fcf2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686:SF12">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08698">
        <property type="entry name" value="Fcf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fcf2 pre-rRNA processing C-terminal" evidence="4">
        <location>
            <begin position="90"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ44792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="207" mass="24492" checksum="B110C5E931235CD9" modified="2009-07-28" version="1">MTEIPTIIETSETESFSERAHVPDDTASLDDLFADLKKESRSVPTIKDFKSIEKSIQSLPKINANLETALQKKPIRIHDPVIPPKKKTTETSDERWFNMKQPEMTPEIKRDLQIIKQRSALDPKRHYKKDKWEIPKFFQMGTIIEGNTEFYSSRLKRKERGKTMVEELLHDDTTKKYFKRKYHEIQQTKTSGRKGFYKKVKNARKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPF6</accession>
    <name>C4YPF6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">enoyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="11">1.3.1.104</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_02355</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.104"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.104" evidence="11"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YPF6"/>
    <dbReference type="PaxDb" id="5476-C4YPF6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02355"/>
    <dbReference type="HOGENOM" id="CLU_026673_17_0_1"/>
    <dbReference type="OMA" id="YGYTQSK"/>
    <dbReference type="OrthoDB" id="7482721at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019166">
        <property type="term" value="F:trans-2-enoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000112">
        <property type="entry name" value="Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000073">
        <property type="entry name" value="Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="13"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ44095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="364" mass="39919" checksum="9384D16089928666" modified="2009-07-28" version="1">MITAQAVLYSQHGEPKDVLFTQKFEIDDENLTPNQVVVKTLASPVNPSDINQIQGVYPSKPEKTTAFGTSEPAAPCGNEGLFEVLKVGDNVKGLEAGDWVIPANVNFGTWRTHALGEEQDFIQLPNPTQSKANGKPQGLSLNQGATISVNPMTAYLMLTHYVKLNPGKDWFIQNGGNSAVGKYASQIGKLLNFNSISVIRDRPNLEEVVEELKELGATQVITEEQNNSKEFGPTIKGWIKESGGEAKLALNCVGGKSSTGIARKLNNNGLMLTYGGMSFQPVTIPTSLHIFKNFTSAGFWVTELLKHNRELKLKTLNQIIEWYESGELKDAKSTETRFDGSKELHELYKDGVANSKSGKQLITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>C4YPZ6</accession>
    <name>C4YPZ6_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Guanine nucleotide-binding protein alpha-2 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CAWG_02550</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="C4YPZ6"/>
    <dbReference type="PaxDb" id="5476-C4YPZ6"/>
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    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:GTPase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Guanine nucleotide-binding protein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
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        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF369">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="142"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="298"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="324"/>
            <end position="330"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="350"/>
            <end position="354"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="419"/>
            <end position="422"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ44285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="502" mass="56794" checksum="8A438DCC6CA5AEE6" modified="2009-07-28" version="1">MGSCASKSADQGNGTSKQQQSAQSTQGKRQQQSQAIQQKNKEKQQSRQKEQQEKHQQQQQQPQPQSPSDSNADGTLKNGSDFYETLKHPSDSSNDNGHLKENHSQDLSNGTANKNLITNPVDAAGNSNPSKDVKVLLLGSGESGKSTIVKQMKILHSDGYTQDELEEYRPFVYKNILDCIKNVINAIIDLQPDLIRKPDSPQLEEDHEEDLKVTGLTSENNHVPTANGSVTNQPPPPPKQRKHILEYDMLNEILDYDYPLNLNQQFDPDIAIKIKKVYETPEVKEFMLQRQGDFYLIDSTDYFLSNLDRICLAGNYEPNVTDVLRTRKKTSGIFIYSFDLGNGLNMNLFDVGGQRSERKKWINCFDNVSTIIFCVALSEYDNFLLEESNTNRLEESLALFDSVVNSRWFSRTTVVLFLNKIDVFAEKLKYSPLENFFPDYKGGSNISNGVKYILWRFNKLNRSGLNIYPHVTQATDTSNIELVMAAVKQTILENSLKDSGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ03</accession>
    <name>C4YQ03_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Acetolactate synthase</fullName>
            <ecNumber evidence="4 12">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_02557</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 12"/>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ03"/>
    <dbReference type="SMR" id="C4YQ03"/>
    <dbReference type="PaxDb" id="5476-C4YQ03"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02557"/>
    <dbReference type="HOGENOM" id="CLU_013748_1_2_1"/>
    <dbReference type="OMA" id="QETDMIG"/>
    <dbReference type="OrthoDB" id="16262at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000008">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000053">
        <property type="entry name" value="Acetolactate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
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        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
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        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="16">
        <location>
            <begin position="89"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="14">
        <location>
            <begin position="285"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="15">
        <location>
            <begin position="492"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="26"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ44292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="683" mass="74304" checksum="90758C14A7AD3AE5" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQ48</accession>
    <name>C4YQ48_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_02602</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the INSIG family.</text>
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        <property type="protein sequence ID" value="EEQ44337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQ48"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02602"/>
    <dbReference type="HOGENOM" id="CLU_088332_0_0_1"/>
    <dbReference type="OMA" id="IEWSSFL"/>
    <dbReference type="OrthoDB" id="205546at2759"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:sterol biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025929">
        <property type="entry name" value="INSIG_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301">
        <property type="entry name" value="INSULIN-INDUCED GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301:SF3">
        <property type="entry name" value="PROTEIN NSG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07281">
        <property type="entry name" value="INSIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="18"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ44337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="334" mass="36744" checksum="811D5CEE171868AC" modified="2009-07-28" version="1">MAELRKIALSNSNLKNMASPSSSTPGSSGASSPQGNGMAKTDSLVNLTQPELYGIFRNDSDTSLSKEFEEDSAEIEFKVNSRLNKSTGTTTSSSSSSEAKYSKNEDFEKYLPLPLKIVVLTLASFIYNEVTSQINFNHTQSNYPLTIKHLFKISSYIHLDEYLAFVGQSKYGYLIDETFALMIQGLVMASFHPILDYYLPKSLTKRLLSSNPNPSSSTSYSTLINDLIRSSVAFLGVSYAIRNIEWSSFLQVAIIYSLVSPGLWLLLDGTISGLIGSLVVSIAACSVVYYQNYQYLNGVGDASPVELVAIWLWIGSFVFGGLIVFGKLGRFLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQQ1</accession>
    <name>C4YQQ1_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">R3H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_02811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000310">
        <property type="protein sequence ID" value="EEQ44540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQQ1"/>
    <dbReference type="PaxDb" id="5476-C4YQQ1"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_02811"/>
    <dbReference type="HOGENOM" id="CLU_676137_0_0_1"/>
    <dbReference type="OMA" id="ALYMKLR"/>
    <dbReference type="OrthoDB" id="278430at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02642">
        <property type="entry name" value="R3H_encore_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ44540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="46505" checksum="A66BCCF5690A86CE" modified="2009-07-28" version="1">MPNNVSTVPAQGMDKNHTAIPSSLLTALSKQQDKLYILHLEKDLIKFIKNSVLGNIKQPEYIIQAQYLKNSYYRLLSHQLCQYYNLQHWNNTFNEIIVTPIPNFDYQQFIKAIEGSDNNEGGEFVKIVSVAHKYKSENTATTTTNNTDAPEQPNKPAPIKKLMVRKIINKPMSDPTPGQAPGTPESEVSDLTKELDESKLISEDTGSSTPISESSENTTNNIESQRASKEALYMKLREEIFENNNEEEEEEEEEEDGDYGTTESQESNNRGYKFHNNFIKGRNHGNYSGYKTTPYQQQQLQHQPPMYNTIPMPVPYQFNPNSQGPPIPGMIYSPYYQPMMYGYAPNYPGAPTNNNNVVPAPKYDKETERRILNNPYIILPNDTKNGKNNNYSNKHTKHKKQFTNTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQS6</accession>
    <name>C4YQS6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Endonuclease</fullName>
            <ecNumber evidence="17">3.1.30.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAWG_04423</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">WO-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.30.-" evidence="17"/>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQS6"/>
    <dbReference type="PaxDb" id="5476-C4YQS6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04423"/>
    <dbReference type="HOGENOM" id="CLU_055174_0_2_1"/>
    <dbReference type="OMA" id="YVMPNQV"/>
    <dbReference type="OrthoDB" id="5418055at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.570.10:FF:000004">
        <property type="entry name" value="Nuclease 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018524">
        <property type="entry name" value="DNA/RNA_endonuclease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01070">
        <property type="entry name" value="NUCLEASE_NON_SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0540">Nuclease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="19">
        <location>
            <begin position="73"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="18">
        <location>
            <begin position="74"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU366055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EEQ46079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="320" mass="35801" checksum="4C8D8532165DF9CE" modified="2009-07-28" version="1">MSKLLVNTLSLGTIGGTALYFWGKSSTPTTPVQSPNLPAPITNPSGGVFDPSAINPQGFFKFGFPGPIHDLANRTEFVSCYDRSTRNPYWVIEHITKASLAKAESNGDRKRSVFKEDEAIPLKFRNRLRDYFRSGFDRGHQAPAADAKFNQLAMDETFYLTNMCPQVGDGFNRDYWSHFEDFVRRLTNQYDDVRVMTGPLYLPKLGADGKYRVTYEVIGSPPNIAVPTHFFKLVVGETQGSEKISCAAFVLPNDVIDNSTPLTSFQVPIEALERSSGLDLLQKVPYYNKQDLCKQVKCEIIVREFPKQVDKVLALPAGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YQX5</accession>
    <name>C4YQX5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein NRD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_04472</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YQX5"/>
    <dbReference type="PaxDb" id="5476-C4YQX5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04472"/>
    <dbReference type="HOGENOM" id="CLU_016577_1_0_1"/>
    <dbReference type="OMA" id="GIVQTCI"/>
    <dbReference type="OrthoDB" id="79367at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031126">
        <property type="term" value="P:sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16984">
        <property type="entry name" value="CID_Nrd1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000397">
        <property type="entry name" value="RNA binding protein Nrd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048892">
        <property type="entry name" value="Nrd1_Seb1_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21380">
        <property type="entry name" value="Nrd1-Seb1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CID" evidence="8">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="436"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="196"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="563"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="616"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="196"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="616"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="678"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ46128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="700" mass="75677" checksum="D4F34E1F5AEB725D" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR31</accession>
    <name>C4YR31_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase II-associated protein RBA50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_04530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RPAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR31"/>
    <dbReference type="PaxDb" id="5476-C4YR31"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04530"/>
    <dbReference type="HOGENOM" id="CLU_031074_0_0_1"/>
    <dbReference type="OMA" id="DQESPYY"/>
    <dbReference type="OrthoDB" id="348201at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039913">
        <property type="entry name" value="RPAP1/Rba50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013929">
        <property type="entry name" value="RPAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013930">
        <property type="entry name" value="RPAP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483:SF18">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08620">
        <property type="entry name" value="RPAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08621">
        <property type="entry name" value="RPAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RPAP1 N-terminal" evidence="4">
        <location>
            <begin position="65"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1 C-terminal" evidence="3">
        <location>
            <begin position="290"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ46184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="52373" checksum="6501DA4F4187B8E2" modified="2009-07-28" version="1">MDFIGEIIEHEIEAPKEPTPKPTIGGFPELKKLKEKKVSRWRQKQQQEQSTTSPKTTEIRSEASKIHQENIEKMAQMSEEEILQEREELLKGLDPKLIESLIGRSKKREATGHEHNGHTHEHAEGYHGWIGSMKTSEGLTDLSQLDKEDVDRALGISSLSLSEPEGGSNTKKVAFDDNIKTVKFEDLDDGIELDPNGWEDVTDVNELVPNNDHIAPDDYQINPDSDEEGLNNTVHFTKPKQPDLDINDPDFFDKLHEKYYPDLPKETEKLSWMTQPMPKQLSTVYESISDMRFDFKGDLIELSAEGEEPKDSSSEIPTYMGLHHHSENPHMAGYTLGELAHLARSTLAGQRCLSIQTLGRILHKLGLHKYSILPTTDSDDPDFTDEIKQLSHNFEDMMWDLIDQLRIIETITEAADEKKTRNLSVRNYAIEALWLYRTGGGRPEITKQTEEDLIAQAVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR38</accession>
    <name>C4YR38_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CAWG_04537</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR38"/>
    <dbReference type="PaxDb" id="5476-C4YR38"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04537"/>
    <dbReference type="HOGENOM" id="CLU_005088_0_0_1"/>
    <dbReference type="OMA" id="CPVIECD"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1056"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1056"/>
            <end position="1073"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ46191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1085" mass="123080" checksum="4E1C075C292B6085" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR75</accession>
    <name>C4YR75_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR75"/>
    <dbReference type="PaxDb" id="5476-C4YR75"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04574"/>
    <dbReference type="HOGENOM" id="CLU_1343113_0_0_1"/>
    <dbReference type="OMA" id="NCMVSAP"/>
    <dbReference type="OrthoDB" id="4067208at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24300" checksum="AA07715905251608" modified="2009-07-28" version="1">MSTATALETTNAEKKFVNTYLELMQLSKNESLDKFNSTQDYNNLSSLGPSLPKCNYKFPEPQNVTKAAESTVTLKFKSIKPPFKFQTELSNIPVNFTIYKVKAQLIESLEILHNAGVTAKDLKLMIKSKVAQDAAALSSLVNTEEPISFNCMVSAPSGGKPAAATSKTDEGDPELEAVSDPVSTTATTSSISEAGWNKIYEIILQDIKDAGKAKELLAKLKQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>C4YR92</accession>
    <name>C4YR92_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YR92"/>
    <dbReference type="PaxDb" id="5476-C4YR92"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04591"/>
    <dbReference type="HOGENOM" id="CLU_900143_0_0_1"/>
    <dbReference type="OMA" id="WRANSID"/>
    <dbReference type="OrthoDB" id="4086732at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="328" mass="37748" checksum="B613593031C82126" modified="2009-07-28" version="1">MSRESSPEYEEFDETYIETPQRISNSPRKNKSTNFLSFRTVRSSPLRQPPIERKHGISLDEESIIQSNKSNSISDLPAISNAPSSPPASIRFRNTIRPTRSIEDIPKKESNTTADLNRQFSKHSKDHNFREFGSSRSSKLNTPKSRKIGFREFPEKNIVHSKVSDDVDTYSYSVLEKVNSTLEELHNYDGNWRANSIDNSENIEPTETDPVSVAKKFTENIDLKRQEVLDNSTPIKPLSREGIAQSQIKSGLLQSTWWSSAKWSKLRKIVKSKSISREEAINSTLLMSELECTNKMELRKRYDFLEKYINRNPNRTTTRGKGRVTKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRA8</accession>
    <name>C4YRA8_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cAMP-independent regulatory protein pac2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRA8"/>
    <dbReference type="SMR" id="C4YRA8"/>
    <dbReference type="PaxDb" id="5476-C4YRA8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04607"/>
    <dbReference type="HOGENOM" id="CLU_070102_0_0_1"/>
    <dbReference type="OMA" id="NTIFVWN"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF1">
        <property type="entry name" value="CAMP INDEPENDENT REGULATORY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="44313" checksum="724186332AB94174" modified="2010-10-05" version="1">MLIISEFNPQLMHSDDSEDDYDHQSSHRNSSNGTTTFNQIITYKGQISSLNDALLIIEACRLQKLPMVTRRLTGIERNKFIKPNTVFVWNETQCGMKRWTDGRLWSASKVYNGNFLVYKQLNKKTKREQEEEESGGQALVKQSFSVVTKDHQRFHLISYYENVPGSFRPKSASNQTTTTVNIPSHDSKFNQLDLSNAIYPDSLLNSIYKRKHQQQQNKQHPQQQTEQLRQQSYSPAILPNSNNNPVSLESNPGAGISSNLYSLMNQTSTHYTPPSSSLSSSSLSSNSSNSSNSSNSSSGSINSQLTTQSSSPLSIPSLHIKSAGYFTSSGPNHNTFTLQKAGPQNRQQRANHPLTLQPLSKISQLSQTPTSGNNNNTGITNDYDSRTVSALNKTWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRD4</accession>
    <name>C4YRD4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CAWG_04633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRD4"/>
    <dbReference type="PaxDb" id="5476-C4YRD4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04633"/>
    <dbReference type="HOGENOM" id="CLU_846081_0_0_1"/>
    <dbReference type="OMA" id="NNDMIIL"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ46287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="345" mass="37185" checksum="EB87C08CCC0CD6F4" modified="2009-07-28" version="1">MNTGSSQDSIPIDNISLGLSTSPLNTISSGGSDSTIGHLNTPPTSRARSGSLFSIWNEPSVNHNNNVSHSHEMATSTSRNRSYTTTAALPSITIDSFSESLQKSSAPRVSTSPFISVPNNDMIILDNFQTNLPRLRSQTISGAPISSQSTLPHPSESLNAPHHFPQVFETVSSNPSSASILPYNQSPQLFDDVDFTRFLITTSFDNPNLGPTKYLLFDNLPLIINAHKLFGVLSNSLNPRMGNIHGIRITTTTTSKLALVECTSIDTAMSLKASFNHLELVPGNILYVAFAKVDDVQNIGQQRVSTTTFTAITFACSTITTITTTTTTTTTNAVTTIISQSQYEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRH9</accession>
    <name>C4YRH9_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endosomal/vacuolar adapter protein YPT35</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PX domain-containing protein YPT35</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CAWG_04679</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Recruits the lipid transfer protein VPS13 to endosomal and vacuolar membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YPT35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRH9"/>
    <dbReference type="SMR" id="C4YRH9"/>
    <dbReference type="PaxDb" id="5476-C4YRH9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04679"/>
    <dbReference type="HOGENOM" id="CLU_070610_2_0_1"/>
    <dbReference type="OMA" id="QWFMTNV"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07280">
        <property type="entry name" value="PX_YPT35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037917">
        <property type="entry name" value="Ypt35_PX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="PX" evidence="10">
        <location>
            <begin position="46"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ46332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="167" mass="19494" checksum="C60A772263E34D0B" modified="2009-07-28" version="1">MNSDTTPTHRNKSNSISQLNKVLPVPIELHNGESLEQHQQNHLNHITNVIVGEYHLISGEFGKSYMTWQIKITINDLDYSSIVLYKRYNEIYQLRQDLLKIFPPHDHTITTNIVPSLPPKDNLSLDRLMMSKNWLEERRKGLQWFLSNVLLNPVFQNCSVVKQFVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRK4</accession>
    <name>C4YRK4_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CAWG_04704</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">WO-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRK4"/>
    <dbReference type="SMR" id="C4YRK4"/>
    <dbReference type="PaxDb" id="5476-C4YRK4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04704"/>
    <dbReference type="HOGENOM" id="CLU_011226_3_0_1"/>
    <dbReference type="OMA" id="VQWATEN"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000006">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000142">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1010:FF:000001">
        <property type="entry name" value="Elongation factor 1-gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1010">
        <property type="entry name" value="Translation elongation factor EF1B, gamma chain, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001662">
        <property type="entry name" value="EF1B_G_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036433">
        <property type="entry name" value="EF1B_G_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00647">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01183">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89942">
        <property type="entry name" value="eEF1-gamma domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50040">
        <property type="entry name" value="EF1G_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="83"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="EF-1-gamma C-terminal" evidence="6">
        <location>
            <begin position="257"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="213"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ46357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="419" mass="47510" checksum="F5B71344AD6B3385" modified="2009-07-28" version="1">MSQGTLYIMEISPRSSILADLIKYFKLDIEIDANTQSESFIKKFPLGKTPAFVGAKGFQLTETIAIANYFLSLIPNQKLLGKNNQEYANIIKYVSLLNQEGVISWAAAYFRLNGRFPYNKKEVDENLKIFNTIGEILEKRLHDFTYLVGERISYADLFAVKVVIGAVATVFGKPFLTKYPSIARWVKTVSQNEIFQGQFKDLKFPEQQLAFVPPKKEKKKDATPKAESAAPKKKETPAAAAAAATSASEEPAAAPKPKHPLEALGKPKNPLDEWKRTYSNEETREVAIPWFWKNQYDPEEWSLWKVDYKYNDELTLTFMSNNLVGGFFNRLSASTKYMFGCMVVYGENNNNGITGAFLVRGQDYVPAFDVAPDWESYEFTKLDGSNEDDKKFINNMFAWDEPVVVNGEKREIADGKVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRQ9</accession>
    <name>C4YRQ9_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_04763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRQ9"/>
    <dbReference type="PaxDb" id="5476-C4YRQ9"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04763"/>
    <dbReference type="HOGENOM" id="CLU_1677620_0_0_1"/>
    <dbReference type="OrthoDB" id="4024815at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="153" mass="17959" checksum="4E01F57C4543CF17" modified="2009-07-28" version="1">MNDNFNSSNFSSFKNSPTLLTSTNEQLNRLWNLILKFDRISITSTDINIEDTDNNSSTGDDQFISIEKFYKLLINYHKLIELITIKNNELTIMKFQCFEIIRNIQQQQQQQKPNTHKMFNQHNSTATYSSSFNETGKKLQDIFNPKEEFDSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRX4</accession>
    <name>C4YRX4_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CAWG_04832</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PaxDb" id="5476-C4YRX4"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04832"/>
    <dbReference type="HOGENOM" id="CLU_000536_6_0_1"/>
    <dbReference type="OMA" id="NAQMGIE"/>
    <dbReference type="OrthoDB" id="5421at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140674">
        <property type="term" value="F:ATP-dependent histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05491">
        <property type="entry name" value="Bromo_TBP7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19517">
        <property type="entry name" value="RecA-like_Yta7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001218">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000016">
        <property type="entry name" value="ATPase family AAA domain-containing protein 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000061">
        <property type="entry name" value="ATPase family, AAA domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045199">
        <property type="entry name" value="ATAD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069:SF0">
        <property type="entry name" value="TAT-BINDING HOMOLOG 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="13">
        <location>
            <begin position="1022"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="348"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1210"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1092"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1223"/>
            <end position="1238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EEQ46477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="1310" mass="148009" checksum="F80EF6B3C05BC6C7" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>C4YRZ8</accession>
    <name>C4YRZ8_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTP-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_04856</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in ribosomal function.</text>
    </comment>
    <dbReference type="EMBL" id="CM000311">
        <property type="protein sequence ID" value="EEQ46501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YRZ8"/>
    <dbReference type="SMR" id="C4YRZ8"/>
    <dbReference type="PaxDb" id="5476-C4YRZ8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04856"/>
    <dbReference type="HOGENOM" id="CLU_044997_0_0_1"/>
    <dbReference type="OMA" id="DVCDQVH"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001436">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="66"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="293"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ46501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="369" mass="41168" checksum="7812F0A3D46D3C51" modified="2010-10-05" version="1">MGILEKIAQIQEELSRTQKNKATEYHIGLLKGKLARYRRELLEPQPGQGSSGGGGQGFEVAKAGDARVSLIGFPSVGKSSFLSKVTNTKSEAANYEFTTLTSVGGILEYNGAEVQIVDLPGIIKAASQGKGRGRQVIAVSRTSDLILMVLDATKGGDQREILENELESMGIRLNKQRPNISIKVKKTGGVKMNSITPPKYLDEKIVTALLKDYKIHNADVLIRDENVTIDDFIDVINDQHITYIKCLYVYNKIDAVSLEECDRLAREPNTVVMSCELDLGIEDLKEEIWRQLDLLRLYTKRRGVQPKFDDPMVVRNNSTILEVCDSIHRDMKNQFKYALVWGSSAKHSPQKCGLTHPIHDEDVVQIVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>C4YS62</accession>
    <name>C4YS62_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="2 8">3.5.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CAWG_04921</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate</text>
            <dbReference type="Rhea" id="RHEA:22936"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="3.5.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="11">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="2 8"/>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YS62"/>
    <dbReference type="PaxDb" id="5476-C4YS62"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_04921"/>
    <dbReference type="HOGENOM" id="CLU_032482_0_2_1"/>
    <dbReference type="OMA" id="PCRKGAH"/>
    <dbReference type="OrthoDB" id="10264777at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000113">
        <property type="entry name" value="N-acetylglucosamine-6-phosphate deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="12">
        <location>
            <begin position="52"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="232"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="322"/>
            <end position="324"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ46565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="413" mass="45226" checksum="DE65523A1F75FA29" modified="2009-07-28" version="1">MSFTRFTNCHLIDNGELYEFTDLYVNNATKRICHPPANPELVSEVIDLKQQILAPGFIDIQNNGIYGLNFSNLGEESTAEDVAEFKRFYRDAMAKYLSTGVTATCPTVTSSFPEVYAKVLPMYKRSVLASQTDSLGAHVEGPFINVQKKGCHPVETFVDAKEGESKLLEVYGDLFDNVCIVTAAPEIAGVLDLIPVVKSKNCVFSIGHTMSDYDTAVKAVEKGATMITHLYNAMPQPHHRNAGVVGLINSPIVDTPYFGLICDGVHVDPSMANLAYRSNPSKCVLVTDAMHLIGLPDGHYKWDSQVIVKTGDRLYLENTDTLAGAATTLPQCVRNLVKWSQISLPQAVMTVTNNAARSIGVDHERGFLNVGCLADFVVLDKSGFVRKVYKLGREVQSSDIPLDRATDKLTAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSF3</accession>
    <name>C4YSF3_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CAWG_05018</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Peripheral membrane protein</topology>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS18 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSF3"/>
    <dbReference type="PaxDb" id="5476-C4YSF3"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05018"/>
    <dbReference type="HOGENOM" id="CLU_003488_0_0_1"/>
    <dbReference type="OMA" id="KFFVFPC"/>
    <dbReference type="OrthoDB" id="1845386at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CHCR"/>
    </dbReference>
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        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007810">
        <property type="entry name" value="Pep3/Vps18_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058919">
        <property type="entry name" value="Pep3/Vps18_RING_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF26">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05131">
        <property type="entry name" value="Pep3_Vps18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26148">
        <property type="entry name" value="VPS18_RING_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pep3/Vps18 beta-propeller" evidence="8">
        <location>
            <begin position="39"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="513"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Pep3/Vps18 RING C-terminal" evidence="9">
        <location>
            <begin position="764"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ46656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="811" mass="94462" checksum="4F0E6DF914C93D57" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSG2</accession>
    <name>C4YSG2_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_05028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSG2"/>
    <dbReference type="PaxDb" id="5476-C4YSG2"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05028"/>
    <dbReference type="HOGENOM" id="CLU_355687_0_0_1"/>
    <dbReference type="OMA" id="INFLWKE"/>
    <dbReference type="OrthoDB" id="6347512at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="731" mass="84802" checksum="74F3E61D302DB272" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>C4YSG6</accession>
    <name>C4YSG6_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CAWG_05032</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000312">
        <property type="protein sequence ID" value="EEQ46669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YSG6"/>
    <dbReference type="PaxDb" id="5476-C4YSG6"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05032"/>
    <dbReference type="HOGENOM" id="CLU_022670_4_1_1"/>
    <dbReference type="OMA" id="SIAKEPH"/>
    <dbReference type="OrthoDB" id="442947at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="67"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="160"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="282"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="249"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="249"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ46669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="365" mass="40248" checksum="B388FFABD96B1E6D" modified="2009-07-28" version="1">MTESLFDTNFTSENESKPEPTQQQQQQSTQQTSQQQQQQPSSSTLTTSIVDQSSTLPSLQDKSNIDALINYRVLVSAKEAGCLIGTNGQVIDSIRNETNTKAGISRLIPGSHERILTVSGKLDDCAKALSYFAQALINANIESYNYFPLKQLSSTPNTEETTILRLLIPNSQMGTLIGSKGARIQQLQNNFNISMIASKSFLPGSNERLVELQGTVDDLYDSLRIISRCLIEDFSSIVGTTYYVPRGNTYNNSHSHSHNNNNNTNTNNNNNNNNNTHGSGGNKTTDTISFPNDIVGALIGKRGSRIDGVRKVSGAMIAISEAIEGENERVFTITGSSHAVDKAKQMIYQNFKREEERRKNEESRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT72</accession>
    <name>C4YT72_CANAW</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CAWG_05358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT72"/>
    <dbReference type="PaxDb" id="5476-C4YT72"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05358"/>
    <dbReference type="HOGENOM" id="CLU_1239973_0_0_1"/>
    <dbReference type="OrthoDB" id="4097129at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ46813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="223" mass="26044" checksum="A4E66BAC90EC7659" modified="2009-07-28" version="1">MSRIYHFDILHSLGDHDITGIQNQIKTCFRYISQENLEALPKQGGFGLLNLRTQLSGGRCRMILHTLIGDQDWQFEIYRLKIQKFINKIQQPKQEGNHQQIVPWYKFLIHQNDELDKALSTTRVLPTHLKTAIKAWIELNKPETRTPENDLYTTIDESYSPTKNYISKDFAPSTDTKYYNSSSKKSQLAKREVLTPSGWTERLDISTEQWKSTLEKLQQNGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-10-05" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT81</accession>
    <name>C4YT81_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CAWG_05367</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">WO-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT81"/>
    <dbReference type="SMR" id="C4YT81"/>
    <dbReference type="PaxDb" id="5476-C4YT81"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05367"/>
    <dbReference type="HOGENOM" id="CLU_032568_0_0_1"/>
    <dbReference type="OMA" id="FDSVAFF"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000119">
        <property type="entry name" value="Ferric reductase transmembrane component, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF28">
        <property type="entry name" value="FRP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="271"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EEQ46822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="592" mass="68247" checksum="69649AE8FC18A699" modified="2010-10-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>C4YT91</accession>
    <name>C4YT91_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CAWG_05377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">WO-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YT91"/>
    <dbReference type="PaxDb" id="5476-C4YT91"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05377"/>
    <dbReference type="HOGENOM" id="CLU_729574_0_0_1"/>
    <dbReference type="OMA" id="DVKWMNS"/>
    <dbReference type="OrthoDB" id="5953249at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="103"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ46832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001429"/>
        </source>
    </evidence>
    <sequence length="364" mass="41775" checksum="59FEEF30A10AF0E1" modified="2009-07-28" version="1">MTGLQDPQDNGKSGIHIHYPNNKKPTYEISKEHLSEMTSHLEALPQFQTLEDESSAHHIIYQSMVDKYASNNQNFKTNPRLADPRTRNNLLELMKDVYGRKSILFALDVEAWELDTNIVTEIGIAIYDPRGQADSLIPTTIQLHIRIKEHLARTNGKYVPHHAHNFNGNTSYIMSEREAATLTQSLINFYFISAESKGTGCYLVGHDLKGDVKWMNSLGVTFPSQFKSLDTNYLFRISHGKENISLKRALAFVHIPFAYLHNAGNDAYYTLLLAMKLCDPHSRVRYRLDVLINVETYPTLTKEEKKERKNRRRQEKLEAIARGEHVEQKPPAPKQTTKKSNRKKLTCESIELESAIEVFDAMFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>C4YTE5</accession>
    <name>C4YTE5_CANAW</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Symplekin/Pta1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CAWG_05434</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida albicans (strain WO-1)</name>
        <name type="common">Yeast</name>
        <dbReference type="NCBI Taxonomy" id="294748"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Candida/Lodderomyces clade</taxon>
            <taxon>Candida</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2009" name="Nature" volume="459" first="657" last="662">
            <title>Evolution of pathogenicity and sexual reproduction in eight Candida genomes.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Rasmussen M.D."/>
                <person name="Lin M.F."/>
                <person name="Santos M.A."/>
                <person name="Sakthikumar S."/>
                <person name="Munro C.A."/>
                <person name="Rheinbay E."/>
                <person name="Grabherr M."/>
                <person name="Forche A."/>
                <person name="Reedy J.L."/>
                <person name="Agrafioti I."/>
                <person name="Arnaud M.B."/>
                <person name="Bates S."/>
                <person name="Brown A.J."/>
                <person name="Brunke S."/>
                <person name="Costanzo M.C."/>
                <person name="Fitzpatrick D.A."/>
                <person name="de Groot P.W."/>
                <person name="Harris D."/>
                <person name="Hoyer L.L."/>
                <person name="Hube B."/>
                <person name="Klis F.M."/>
                <person name="Kodira C."/>
                <person name="Lennard N."/>
                <person name="Logue M.E."/>
                <person name="Martin R."/>
                <person name="Neiman A.M."/>
                <person name="Nikolaou E."/>
                <person name="Quail M.A."/>
                <person name="Quinn J."/>
                <person name="Santos M.C."/>
                <person name="Schmitzberger F.F."/>
                <person name="Sherlock G."/>
                <person name="Shah P."/>
                <person name="Silverstein K.A."/>
                <person name="Skrzypek M.S."/>
                <person name="Soll D."/>
                <person name="Staggs R."/>
                <person name="Stansfield I."/>
                <person name="Stumpf M.P."/>
                <person name="Sudbery P.E."/>
                <person name="Srikantha T."/>
                <person name="Zeng Q."/>
                <person name="Berman J."/>
                <person name="Berriman M."/>
                <person name="Heitman J."/>
                <person name="Gow N.A."/>
                <person name="Lorenz M.C."/>
                <person name="Birren B.W."/>
                <person name="Kellis M."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="19465905"/>
            <dbReference type="DOI" id="10.1038/nature08064"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">WO-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM000313">
        <property type="protein sequence ID" value="EEQ46886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="C4YTE5"/>
    <dbReference type="PaxDb" id="5476-C4YTE5"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAWG_05434"/>
    <dbReference type="HOGENOM" id="CLU_021804_0_0_1"/>
    <dbReference type="OMA" id="AREMCLN"/>
    <dbReference type="OrthoDB" id="331600at2759"/>
    <dbReference type="Proteomes" id="UP000001429">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021850">
 